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Double Helix by James D. Watson, Gunther S. Stent
Illustrations PHOTOGRAPHS Crick and Watson, along the backs Francis in the Cavendish Maurice Wilkins World Wide Photos The microbial genetics meeting, Copenhagen, March Linus Pauling Information Office, California Institute of Technology Sir Lawrence Bragg Rosalind Franklin X-ray diffraction photograph of DNA, A form Elizabeth Watson In Paris, spring 1952 The meeting at Royaumont, July 1952 In the Italim Alps, August 1952 Early ideas on the DNA-RNA-protein relation X-ray diffraction photograph of DNA, B form Original model of the double helix Watson and Crick in front of the model Photograph A. C. Barrington Brown Morning coffee in the Cavendish photograph A. C. Barrington Brown Letter to Max Delbrück In Stockholm, December 1962 Svenskt Pressfoto, Stockholm DIAGRAMS Short section of DNA, 1951 Chemical structures of the DNA bases, 1951 Covalent bonds of the sugar-phosphate backbone Schematic view of a nucleotide Mg++ ions binding phosphate groups Schematic view of DNA, like-with-like base pairs Base pairs for the like-with-like structure Tautomeric forms of guanine and thymine Base pairs for the double helix Schematic illustration of the double helix DNA replication THE DOUBLE HELIX IN THE summer of 1955, I arranged to join some friends who were going into the Alps.
Nonetheless, I feel the story should be told, partly because many of my scientific friends have expressed curiosity about how the double helix was found, and to them an incomplete version is better than none. But even more important, I believe, there remains general ignorance about how science is “done.” That is not to say that all science is done in the manner described here. This is far from the case, for styles of scientific research vary almost as much as human personalities. On the other hand, I do not believe that the way DNA came out constitutes an odd exception to a scientific world complicated by the contradictory pulls of ambition and the sense of fair play. The thought that I should write this book has been with me almost from the moment the double helix was found. Thus my memory of many of the significant events is much more complete than that of most other episodes in my life.
Building on the work of competitors they were determined to beat, Crick and Watson had correctly deduced the molecular structure of deoxyribonucleic acid, DNA. That structure, they reported in a short article in Nature just weeks later, was the beguilingly beautiful “double helix.” Noting that the helix could “unzip” and copy itself, Crick and Watson confirmed what had hitherto only been suspected: that DNA was the substance that embodied the genetic code. Their brilliant insight—which heralded a new age in biology and medicine—proved to be the scientific coup of the second half of the century. Watson tells how they pulled it off in this now-classic memoir. First published in 1968 and in print for more than three decades, The Double Helix remains unique in the annals of science writing. The discovery it describes was of a magnitude comparable, in terms of scientific and social significance, to the breakthroughs that led to the splitting of the atom and the invention of the computer.
Life's Greatest Secret: The Race to Crack the Genetic Code by Matthew Cobb
a long time ago in a galaxy far, far away, anti-communist, Asilomar, Asilomar Conference on Recombinant DNA, Benoit Mandelbrot, Berlin Wall, bioinformatics, Claude Shannon: information theory, conceptual framework, Copley Medal, dark matter, discovery of DNA, double helix, Drosophila, epigenetics, factory automation, From Mathematics to the Technologies of Life and Death, James Watt: steam engine, John von Neumann, Kickstarter, New Journalism, Norbert Wiener, phenotype, post-materialism, Stephen Hawking
This breakthrough brings the development of organic sensors, for both environmental and medical uses, much closer. * Although we generally describe the structure of DNA as a double helix, it is in fact a bit more complicated than this. Unlike a screw thread, which has a constant pitch or interval between each turn, the double helix has two different intervals, which alternate as the molecule spirals round. These are known as the major and minor grooves – the major groove, which is larger, tends to be the point at which DNA-binding proteins affect gene activity, as the sequence of bases is physically more accessible there. Above all, the DNA double helix spirals in only one direction – anticlockwise as seen from the top, or right-handed, like a normal screw. It is easy to get confused about which way the double helix should spiral, and in many representations of DNA the molecule spirals the wrong way.
In a process known as translation, tRNA molecules attached to an amino acid shuttle through the ribosome, bind with the mRNA codon and release their amino acid, thereby creating a protein chain. AUG FOREWORD In April 1953, Jim Watson and Francis Crick published a scientific paper in the journal Nature in which they described the double helix structure of DNA, the stuff that genes are made of. In a second article that appeared six weeks later, Watson and Crick put forward a hypothesis with regard to the function of the ‘bases’ – the four kinds of molecule that are spaced along each strand of the double helix and which bind the two strands together. They wrote: ‘it therefore seems likely that the precise sequence of the bases is the code which carries the genetical information.’ This phrase, which was almost certainly the work of Crick, must have seemed both utterly strange and completely familiar to those who read the article.
As he put it: ‘The instant I saw the picture my mouth fell open and my pulse began to race.’46 In the centre was an X shape; Watson was a crystallographic novice, but from his discussions with Crick, who had been working on the crystallographic interpretation of helical molecular structures, he knew that the X could only come from a helix. The significance of photo 51 in the identification of the double helix structure of DNA has often been overstated, mainly because of the weight given to it in Watson’s own world-famous account, The Double Helix. In reality, the insight given by the photo was extremely limited. Everyone at King’s – even Franklin – now accepted that the B form was helical, and without any more precise details of the measurements of the molecule, all that happened was that Watson’s preconception was confirmed – DNA had a helical structure. Furthermore, there was nothing underhand going on – Watson was shown the photo in perfectly legitimate circumstances.
A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Jennifer A. Doudna, Samuel H. Sternberg
3D printing, Asilomar, Asilomar Conference on Recombinant DNA, carbon footprint, Chuck Templeton: OpenTable:, double helix, Drosophila, Mark Zuckerberg, microbiome, mouse model, phenotype, Ralph Waldo Emerson, Richard Feynman, Silicon Valley, Skype, stem cell, Steven Pinker
See also therapeutics WHIM syndrome, 3–6, 14 X-linked recessive, 169 diseases, mitochondrial, 196 diversity, 233 DMD (Duchenne muscular dystrophy), 169–70 DMD gene, 169 DNA, 8, 9–15, 104–8 base pairs, 9 double helix, 9–11, 10 editing source code of, 22–26 mutations, 223 repair process, 92–93, 104–8 repeating sequences, 41–42, 43. See also CRISPR sequencing, 14–15 tactics for editing, 100 DNA, cutting, 27–30, 32, 33, 34, 47, 66 Cas proteins and, 65 Cas1 and, 64 by Cas9, 76–77, 79–81, 79, 91 crucial components for, 80 experiments, 78 programmable, 83 DNA, lab-made, 22 DNA, recombinant, 19, 201, 205, 207 DNA repair, 104–8 dogs, 143–44 Dolly (sheep), 191 double helix, 9–11, 10 double helix, DNA-RNA, 58, 79 double helix, RNA-RNA, 58 Double Helix, The (Watson), 10 double muscling, 130–32, 132, 133, 143 double-strand-break model, 27–29 Doudna, Jennifer American Society for Microbiology conference, 70–74 on animal models, 139–40 Caribou Biosciences, 66 Cas9.
By virtue of the molecule’s two-strandedness and the rules governing how those strands assemble (A with T, G with C), each strand acts as a perfect template for its matching pair. Shortly before cell reproduction, the two strands are separated by an enzyme that “unzips” the double helix right down the middle. After that, other enzymes build a new partner strand for each single strand simply by using the same base-pairing rules, resulting in two exact copies of the original double helix. My own introduction to the DNA double helix coincided with my discovery that scientists could learn about molecules that were too tiny to see with even the most powerful light microscopes. I came home from school one day when I was about twelve or so to find a tattered copy of James Watson’s The Double Helix lying on my bed. (My dad would occasionally pick up books for me at used bookstores to see if they sparked any interest.) Thinking this book was a detective novel—which it was!
This process converted the long repetitive arrays in DNA into a library of shorter RNA molecules, each containing a single sequence derived from a particular phage. These findings hinted at the vital role CRISPR RNA plays within the bacterial immune system—a role made possible by the basic functions of RNA itself. Since RNA is chemically so similar to DNA, it can create double helixes of its own by using base-pairing interactions, the same process that forms the famous double helix of DNA. Matching RNA strands can pair with each other, forming an RNA-RNA double helix, but a single strand of RNA can also pair with a matching single strand of DNA, forming an RNA-DNA double helix. This versatility, and the variety of different sequences found in CRISPR RNA, gave scientists an intriguing idea. It seemed possible that these CRISPR RNA molecules could single out both DNA and RNA molecules from invading phages for attack during an infection by pairing with any that they matched and initiating some sort of immune response in the cell.
The Gene: An Intimate History by Siddhartha Mukherjee
Albert Einstein, Alfred Russel Wallace, All science is either physics or stamp collecting, Any sufficiently advanced technology is indistinguishable from magic, Asilomar, Asilomar Conference on Recombinant DNA, Benoit Mandelbrot, butterfly effect, dark matter, discovery of DNA, double helix, Drosophila, epigenetics, Ernest Rutherford, experimental subject, Internet Archive, invisible hand, Isaac Newton, longitudinal study, medical residency, moral hazard, mouse model, New Journalism, out of africa, phenotype, Pierre-Simon Laplace, Ponzi scheme, Ralph Waldo Emerson, Scientific racism, stem cell, The Bell Curve by Richard Herrnstein and Charles Murray, Thomas Malthus, twin studies
“Superficially, the X-ray data”: Watson, Annotated and Illustrated Double Helix, 73. “check it with”: Ibid. Wilkins, Franklin, and her student, Ray Gosling: Bill Seeds and Bruce Fraser accompanied them on this visit. As Gosling recalled, “Rosalind let rip”: Watson, Annotated and Illustrated Double Helix, 91. “His mood”: Ibid., 92. In the first weeks of January 1953: Linus Pauling and Robert B. Corey, “A proposed structure for the nucleic acids,” Proceedings of the National Academy of Sciences 39, no. 2 (1953): 84–97. “V.Good. Wet Photo”: http://profiles.nlm.nih.gov/ps/access/KRBBJF.pdf. “important biological objects come in pairs”: Watson, Double Helix, 184. he would later write defensively: Anne Sayre, Rosalind Franklin & DNA (New York: W. W. Norton, 1975), 152. “Suddenly I became aware”: Watson, Annotated and Illustrated Double Helix, 207. “Upon his arrival”: Ibid., 208.
Remarkably, the three R’s of gene physiology are acutely dependent on the molecular structure of DNA—on the Watson-Crick base pairing of the double helix. Gene regulation works through the transcription of DNA into RNA—which depends on base pairing. When a strand of DNA is used to build the RNA message, it is the pairing of bases between DNA and RNA that allows a gene to generate its RNA copy. During replication, DNA is, once again, copied using its image as a guide. Each strand is used to generate a complementary version of itself, resulting in one double helix that splits into two double helices. And during the recombination of DNA, the strategy of interposing base against base is deployed yet again to restore damaged DNA. The damaged copy of a gene is reconstructed using the complementary strand, or the second copy of the gene, as its guide.V The double helix has solved all three of the major challenges of genetic physiology using ingenious variations on the same theme.
Avery Collection: Biographical information,” National Institutes of Health, http://profiles.nlm.nih.gov/ps/retrieve/Narrative/CC/p-nid/35. No one knew or understood the chemical structure: Robert C. Olby, The Path to the Double Helix: The Discovery of DNA (New York: Dover Publications, 1994), 107. Swiss biochemist, Friedrich Miescher: George P. Sakalosky, Notio Nova: A New Idea (Pittsburgh, PA: Dorrance, 2014), 58. extremely “unsophisticated” structure: Olby, Path to the Double Helix, 89. “stupid molecule”: Garland Allen and Roy M. MacLeod, eds., Science, History and Social Activism: A Tribute to Everett Mendelsohn, vol. 228 (Dordrecht: Springer Science & Business Media, 2013), 92. “structure-determining, supporting substance”: Olby, Path to the Double Helix, 107. “primordial sea”: Richard Preston, Panic in Level 4: Cannibals, Killer Viruses, and Other Journies to the Edge of Science (New York: Random House, 2009), 96.
Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life by J. Craig Venter
Albert Einstein, Alfred Russel Wallace, Asilomar, Barry Marshall: ulcers, bioinformatics, borderless world, Brownian motion, clean water, discovery of DNA, double helix, epigenetics, experimental subject, global pandemic, Isaac Newton, Islamic Golden Age, John von Neumann, Louis Pasteur, Mars Rover, Mikhail Gorbachev, phenotype, Richard Feynman, stem cell, the scientific method, Thomas Kuhn: the structure of scientific revolutions, Turing machine
In 1944 came the first clear evidence that DNA was in fact the information-carrier, not protein. Schrödinger’s book motivated the American James Watson and Briton Francis Crick to seek that code-script, which ultimately led them to DNA and to discover the most beautiful structure in all biology, the double helix, within whose turns lay the secrets of all inheritance. Each strand of the double helix is complementary to the other, and they therefore run in opposite (anti-parallel) directions. As a result the double helix can unzip down the middle, and each side can serve as a pattern or template for the other, so that the DNA’s information can be copied and passed to progeny. On August 12, 1953, Crick sent Schrödinger a letter indicating as much, adding that “your term ‘aperiodic crystal’ is going to be a very apt one.”
Thank you for buying an authorized edition of this book and for complying with copyright laws by not reproducing, scanning, or distributing any part of it in any form without permission. You are supporting writers and allowing Penguin to continue to publish books for every reader. LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA Venter, J. Craig. Life at the speed of light : from the double helix to the dawn of digital life / J. Craig Venter. pages cm Includes bibliographical references and index. ISBN 978-1-101-63802-6 1. Science—Social aspects. 2. Biology—Philosophy. 3. Artificial life. 4. Genomics. I. Title. Q175.5.V44 2013 303.48'3—dc23 2013017049 To the team that contributed to making the first synthetic cell a reality: Mikkel A. Algire, Nina Alperovich, Cynthia Andrews-Pfannkoch, Nacyra Assad-Garcia, Kevin C.
Schrödinger went on to state that the “code-script” could be as simple as a binary code: “Indeed, the number of atoms in such a structure need not be very large to produce an almost unlimited number of possible arrangements. For illustration, think of the Morse code. The two different signs of dot and dash in well-ordered groups of not more than four allow of thirty different specifications.”23 Even though von Neumann conceived his self-replicating automaton some years before the actual hereditary code in the DNA double helix was discovered, he did lay stress on its ability to evolve. He told the audience at his Hixon lecture that each instruction that the machine carried out was “roughly effecting the functions of a gene” and went on to describe how errors in the automaton “can exhibit certain typical traits which appear in connection with mutation, lethally as a rule, but with a possibility of continuing reproduction with a modification of traits.”
Life on the Edge: The Coming of Age of Quantum Biology by Johnjoe McFadden, Jim Al-Khalili
agricultural Revolution, Albert Einstein, Alfred Russel Wallace, bioinformatics, complexity theory, dematerialisation, double helix, Douglas Hofstadter, Drosophila, Ernest Rutherford, Gödel, Escher, Bach, invention of the printing press, Isaac Newton, James Watt: steam engine, Louis Pasteur, New Journalism, phenotype, Richard Feynman, Schrödinger's Cat, theory of mind, traveling salesman, uranium enrichment, Zeno's paradox
This is precisely what happens when genes are copied during cell division. The two strands of the double helix with their complementary information are pulled apart to allow an enzyme called DNA polymerase access to each separated strand. The enzyme then attaches to a single strand and slides along the chain of nucleotides, reading each genetic letter and, with almost unerring accuracy, inserting a complementary base into the growing strand: whenever it sees an A it inserts a T, whenever it sees a G it inserts a C, and so on until it has made a complete complementary copy. The same process is repeated on the other strand, giving rise to two copies of the original double helix: one for each daughter cell. Figure 7.1: The structure of DNA: (a) shows Watson and Crick’s double helix; (b) shows a close-up of the paired genetic letters A and T; (c) shows a close-up of the paired genetic letters G and C.
Conventional chemistry, driven by those Boltzmann ball-like molecules, just didn’t seem capable of providing the means to store, copy and accurately transmit genetic information. The answer was famously provided in 1953 when James Watson and Francis Crick, working in the Cavendish Laboratory in Cambridge, managed to fit a remarkable structure to the experimental data obtained from DNA by their colleague Rosalind Franklin: the double helix. Each DNA strand was found to be a kind of molecular string made up of atoms of phosphorus, oxygen and a sugar called deoxyribose, with chemical structures called nucleotides*6 strung out like beads on that string. These nucleotide beads come in four varieties: adenine (A), guanine (G), cytosine (C) and thymine (T), so their arrangement along the DNA strand provides a one-dimensional sequence of genetic letters such as “GTCCATTGCCCGTATTACCG.”
And, as we will discover in chapter 7, identification of the double helical DNA strand also solved the problem of how genetic information is copied. At a stroke, two of the greatest mysteries of science had been solved. The discovery of the structure of DNA provided a mechanistic key that unlocked the mystery of genes. Genes are chemicals and chemistry is just thermodynamics; so did the discovery of the double helix finally bring life entirely into the realm of classical science? Life’s curious grin In Lewis Carroll’s Alice’s Adventures in Wonderland, the Cheshire cat has a habit of disappearing, leaving only his grin, prompting Alice to remark that she has “often seen a cat without a grin but never a grin without a cat.” Many biologists experience similar bemusement when, despite knowing how thermodynamics operates in living cells and how genes encode everything that is required to form the cell, the mystery of what life really is continues to grin back at them.
The Biology of Belief: Unleashing the Power of Consciousness, Matter & Miracles by Bruce H. Lipton
Albert Einstein, Benoit Mandelbrot, correlation does not imply causation, discovery of DNA, double helix, Drosophila, epigenetics, Isaac Newton, Mahatma Gandhi, mandelbrot fractal, Mars Rover, On the Revolutions of the Heavenly Spheres, phenotype, placebo effect, randomized controlled trial, selective serotonin reuptake inhibitor (SSRI), stem cell
As I conjured up a biocomputer, I realized that the nucleus is simply a memory disk, a hard drive containing the DNA programs that encode the production of proteins. Let’s call it the Double Helix Memory Disk. In your home computer you can insert such a memory disk containing a large number of specialized programs like word processing, graphics, and spreadsheets. After you download those programs into active memory, you can remove the disk from the computer without interfering with the program that is running. When you remove the Double Helix Memory Disk by removing the nucleus, the work of the cellular protein machine goes on because the information that created the protein machine has already been downloaded. Enucleated cells get into trouble only when they need the gene programs in the ejected Double Helix Memory Disk to replace old proteins or make different proteins. I had been trained as a nucleus-centered biologist as surely as Copernicus had been trained as an Earth-centered astronomer, so it was with a jolt that I realized that the gene-containing nucleus does not program the cell.
The code for recreating the protein machinery of the cell had been cracked! Watson and Crick also explained why DNA is the perfect hereditary molecule. Each DNA strand is normally intertwined with a second strand of DNA, a loosely wrapped configuration known as the “double helix.” The genius of this system is that the sequences of DNA bases on both strands are mirror images of each other. When the two strands of DNA unwind, each single strand contains the information to make an exact, complementary copy of itself. So through a process of separating the strands of a double helix, DNA molecules become self-replicating. This observation led to the assumption that DNA “controlled” its own replication … it was its own “boss.” The “suggestion” that DNA controlled its own replication and served as the blueprint for the body’s proteins led Francis Crick to create biology’s Central Dogma, the belief that DNA rules.
He suggested that “hereditary factors” passed from parent to child control the characteristics of an individual’s life. That bit of insight set scientists off on a frenzied attempt to dissect life down to its molecular nuts and bolts, for within the structure of the cell was to be found the heredity mechanism that controlled life. The search came to a remarkable end fifty years ago when James Watson and Francis Crick described the structure and function of the DNA double helix, the material of which genes are made. Scientists finally figured out the nature of the “hereditary factors” that Darwin had written about in the 19th century. The tabloids heralded the brave new world of genetic engineering with its promise of designer babies and magic bullet medical treatments. I vividly remember the large block print headlines that filled the front page on that memorable day in 1953: “Secret of Life Discovered.”
P53: The Gene That Cracked the Cancer Code by Sue Armstrong
Then an enzyme ‘glue’ called DNA ligase seals the fragments of copied DNA into a continuous double-sided strand that rewinds itself automatically. In the replicated DNA, one strand of the double helix will be from the original (known as the parent strand) and the other will be the new copy (known as the daughter strand). The cell is now ready to divide into two cells with equal shares of identical genetic material. This process, going on ceaselessly in billions of cells in our bodies as we repair and replace tissue and our hair and nails grow, is so efficient that mutations – mistakes that escape the proofreader – occur at the rate of about one in 109 nucleotides per replication. It’s interesting to note that this knowledge, this understanding of how the machinery of life works, is built on the foundations of Watson and Crick’s discovery of the structure of DNA. The double helix – the spiral staircase drawn originally for their paper in Nature by Crick’s wife Odile – remains one of the iconic images of 20th-century science.
And for nearly a decade, only a tiny proportion of scientists writing about DNA in professional journals mentioned the double helix. It was a beautifully elegant model, but many biochemists, intensely preoccupied with working out how we synthesise the proteins in our cells, were sceptical that genes – still rather an abstract notion in the early 1950s – had anything to do with it. CHAPTER FIVE Cloning the Gene In which we hear about the huge technical challenge and the hot competition to clone p53 as the first step to discovering how the gene and its protein work. *** We stand on the wrong side of the tapestry – a confusion of colours, knots and loose ends. But, be assured, on the other side there is a pattern. Anon The cool reception and slow build-up of recognition for the double helix – culminating in the Nobel Prize for James Watson, Francis Crick and the biophysicist Maurice Wilkins in 1962 – are instructive.
However, no microscope currently available to most labs can show DNA in enough detail for scientists to be able to determine the order of the ‘bases’ making up the molecule. Thus the genes which are carried on the chromosomes – not as discrete chunks of DNA but as segments along the continuous stand of genetic material – remain unseeable, and it is these scraps of information that carry the recipes for the proteins that the scientists are after. The famous corkscrew structure of DNA – the double helix discovered by James Watson and Francis Crick in 1953 – is made up of components called nucleotides, which stack one on top of the other like nano-sized blocks of Lego to form long chains. Each nucleotide, or block, has three components: a sugar molecule called a deoxyribose (the D in DNA), a phosphate group and a nitrogen ‘base’. These bases come in four different types: adenine (represented by A), thymine (T), guanine (G) and cytosine (C).
Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease and Inheritance by Nessa Carey
Albert Einstein, British Empire, Build a better mousetrap, conceptual framework, discovery of penicillin, double helix, Drosophila, epigenetics, Fellow of the Royal Society, life extension, mouse model, phenotype, selective serotonin reuptake inhibitor (SSRI), stem cell, stochastic process, Thomas Kuhn: the structure of scientific revolutions, twin studies
The fabric strips that the teeth are stitched on to on a zip are the DNA backbones. There are always two backbones facing each other, like the two sides of the zip, and DNA is therefore referred to as double-stranded. The two sides of the zip are basically twisted around to form a spiral structure – the famous double helix. Figure 3.1 is a stylised representation of what the DNA double helix looks like. Figure 3.1 A schematic representation of DNA. The two backbones are twisted around each other to form a double helix. The helix is held together by chemical bonds between the bases in the centre of the molecule. The analogy will only get us so far, however, and that’s because the teeth of the DNA zip aren’t all equivalent. If one of the teeth is an A base, it can only link up with a T base on the opposite strand.
Because C has to pair up with G, and A has to pair up with T, the cells can use the existing DNA as a template to make the new strands. Each daughter cell ends up with a new perfect copy of the DNA, in which one of the strands came from the original DNA molecule and the other was newly synthesised. Figure 3.2 The first stage in replication of DNA is the separation of the two strands of the double helix. The bases on each separated backbone act as the template for the creation of a new strand. This ensures that the two new double-stranded DNA molecules have exactly the same base sequence as the parent molecule. Each new double helix of DNA has one backbone that was originally part of the parent molecule (in black) and one freshly synthesised backbone (in white). Even in nature, in a system which has evolved over billions of years, nothing is perfect and occasionally the replication machinery makes a mistake.
But what about the other situation, the example of skin stem cells dividing very frequently but always just creating new skin cells, rather than some other cell type such as bone? In this situation, the pattern of DNA methylation is passed from mother cell to daughter cells. When the two strands of the DNA double helix separate, each gets copied using the base-pairing principle, as we saw in Chapter 3. Figure 4.2 illustrates what happens when this replication occurs in a region where the CpG is methylated on the C. Figure 4.2 This schematic shows how DNA methylation patterns can be preserved when DNA is replicated. The methyl group is represented by the black circle. Following separation of the parent DNA double helix in step 1, and replication of the DNA strands in step 2, the new strands are ‘checked’ by the DNA methyltransferase 1 (DNMT1) enzyme. DNMT1 can recognise that a methyl group at a cytosine motif on one strand of a DNA molecule is not matched on the newly synthesised strand.
A Brief History of Everyone Who Ever Lived by Adam Rutherford
23andMe, agricultural Revolution, Albert Einstein, Alfred Russel Wallace, bioinformatics, British Empire, colonial rule, dark matter, delayed gratification, demographic transition, double helix, Drosophila, epigenetics, Google Earth, Isaac Newton, Kickstarter, longitudinal study, meta analysis, meta-analysis, out of africa, phenotype, sceptred isle, theory of mind, Thomas Malthus, twin studies
Since 1953, we’ve known that the double helix is how DNA is built, giving it the impressive ability to copy itself and allow those copies to build cells just like the ones they came from. And since the 1960s we’ve known how DNA encodes proteins, and that all life is built of, or by, proteins. Those titans of science, Gregor Mendel, Francis Crick, James Watson, Rosalind Franklin and Maurice Wilkins, stood on their predecessors’ and colleagues’ shoulders, and would in turn be the giants from whose shoulders all biologists would see into the future. The unravelling of these mysteries were the great science stories of the twentieth century, and by the beginning of the twenty-first the principles of biology were set in place. In cracking the universal genetic code, and unwinding the double helix, we had unveiled a set of simple rules of life.
With his proposed theory of descent with modification in the distant future, light will be shed on our own story: to be continued. That time has come. There is now another way to read our pasts, and floodlights are being shone on our origins. You carry an epic poem in your cells. It’s an incomparable, sprawling, unique, meandering saga. About a decade ago, fifty years after the discovery of the double helix, our ability to read DNA had improved to the degree that it was transformed into a historical source, a text to pore over. Our genomes, genes and DNA house a record of the journey that life on Earth has taken – 4 billion years of error and trial that resulted in you. Your genome is the totality of your DNA, 3 billion letters of it, and due to the way it comes together – by the mysterious (from a biological point of view) business of sex – it is unique to you.
The ability to read DNA was pioneered by the unassuming English genius Fred Sanger in the late 1970s, using a process that copied the original sequence millions of times. To do that, your ingredients need to include the alphabet you’re writing in; DNA only consists of four letters, more formally called nucleotide bases – A, T, C and G. You also need an enzyme whose job it is simply to copy and link up the bases of DNA, called a polymerase. Throw all these ingredients into a tube and set the temperature right, and the double helix will separate into single strands, which serve as templates to replace the letters that would form the missing strand. You end up with millions of copies of the original template. Each one of the letters of DNA physically links to the one that precedes it and the one that follows, whereas English full stops halt any sentence. The polymerase molecule trundles along adding the next letter one at a time like a typewriter copying a line of text.
Erwin Schrodinger and the Quantum Revolution by John Gribbin
Albert Einstein, Albert Michelson, All science is either physics or stamp collecting, Arthur Eddington, British Empire, Brownian motion, double helix, Drosophila, Edmond Halley, Ernest Rutherford, Fellow of the Royal Society, Henri Poincaré, Isaac Newton, Johannes Kepler, John von Neumann, lateral thinking, Richard Feynman, Schrödinger's Cat, Solar eclipse in 1919, The Present Situation in Quantum Mechanics, the scientific method, trade route, upwardly mobile
The cat in the box From Oxford with love Chapter Ten: There, and Back Again Whistling in the dark Reality bites The unhappy return Belgian interlude Chapter Eleven: “The Happiest Years of My Life” “Dev” Settling in Early days at the DIAS “Family” life in Dublin The post-war years Many worlds Chapter Twelve: What Is Life? Life itself Quantum chemistry The green pamphlet Schrödinger’s variation on the theme The double helix Chapter Thirteen: Back to Vienna Farewell to Dublin Home is the hero Declining years The triumph of entropy Chapter Fourteen: Schrödinger’s Scientific Legacy Hidden reality and a mathematician’s mistake The Bell test and the Aspect experiment Quantum cryptography and the “no cloning” theorem Quantum teleportation and classical information The quantum computer and the Multiverse Quantum physics and reality Postscript Sources and Further Reading Index Copyright © 2013 by Mary and John Gribbin.
He was a disciple of Arthur Schopenhauer, with a profound interest in philosophy and Eastern religion, particularly espousing the Hindu Vedanta and subscribing to the idea of a single cosmic consciousness of which we are all part. He studied colour vision, and wrote a book, What Is Life?, which Francis Crick and James Watson each independently cited as a major influence on the work which led them to the discovery of the DNA double helix. Schrödinger also addressed questions such as “What is a law of nature?” and whether or not the world is in principle completely deterministic and predictable. He wrote poetry (badly) and a book about the science and philosophy of ancient Greece. Schrödinger’s private life was no less interesting. Brought up in comfort in the last days of the Austro-Hungarian Empire, he served as an artillery officer in the First World War and suffered the consequences of the post-war blockade of Austria (a long-forgotten Allied atrocity which caused mass starvation) and the runaway inflation of the early 1920s.
The most important feature of DNA is that strung out along the length of the molecule there is a series of chemical subunits called bases, which are denoted by the letters A, C, T, and G. Strings of these four bases can convey information in what is usually called a code, but which I prefer to think of as a language, in the same way that the twenty-six letters of the alphabet are used in long strings to convey information in this book. But DNA molecules do not usually exist in isolation. They come in pairs, with one long molecule twined around its partner in the famous double helix arrangement. The two molecules in each helix are not identical, but are like mirror images of one another; everywhere one molecule has an A, its partner has a T; everywhere one molecule has a C, its partner has a G; everywhere one molecule has a G, its partner has a C; everywhere one molecule has a T, its partner has an A. So under the right circumstances (which occur when a living cell divides) the two halves of the helix can unwind, and each single strand can build itself a new partner from the chemical material surrounding it inside the cell, by making appropriate links between bases.
The Gene Machine by Venki Ramakrishnan
As the maps improved, we were able to find even weaker sites – ones that SOLVE couldn’t identify automatically – and throwing them into the calculations made the maps even better. Suddenly, a month after I had arrived in Cambridge, there it was: a long RNA double helix that ran right down the face of the 30S subunit. Unusually for me, it was fairly late, and I rushed out of the graphics room in the LMB and found Richard Henderson, who was famous for working late into the night. He agreed it looked like a double helix. Excitedly, I sent it off to Utah. I almost wished I could have been there when they saw it. Figure 11.1 An exciting moment – being able to see a clear RNA double helix, with little bumps for the phosphate groups on each strand Brian very quickly identified the outlines of the 30S and its characteristic shape in the map. He then went on to find lots of other double helical regions of RNA.
In each molecule, the two strands of DNA that intertwine to form a double helix run in opposite directions. Each strand has a backbone of alternating sugar and phosphate groups, and one of four types of bases – A, T, C, or G – is attached to the sugar and faces the inside of the helix. While playing with cardboard cutouts of the bases, Watson arrived at a brilliant insight: he realized that an A on one strand could chemically bond or pair to a T on the other but not to any of the other bases, while a G on one strand could similarly pair with a C on the other. In doing so, the shape of each base pair, whether it was AT or CG, was about the same, which meant that regardless of the order of the bases, the overall shape and dimensions of the double helix was about the same. This formation of base pairs meant that the order of the bases on one strand would precisely specify the order on the other strand.
Matt Ridley, author of Genome and Francis Crick: Discoverer of the Genetic Code ‘An enchanting and invigorating work, Gene Machine casts a many-angled light on the world of science, the nature of discovery, and on one of the deepest mysteries of twentieth-century biology. Ramakrishnan, one of the key players in deciphering the molecular basis of protein translation, gives us both a rollicking scientific story and a profoundly human tale. In the tradition of The Double Helix, Gene Machine does not hesitate to highlight the process by which science advances: moving through fits and starts, often underscored by deep rivalries and contests, occasionally pitching towards error and misconception, but ultimately advancing towards profound and powerful truths. An outsider to the world of ribosome biology – an Indian immigrant, a physicist by training – Ramakrishnan retains his “outsider’s” vision throughout the text, reminding us about the corrosive nature of scientific prizes, and the intensity of competition that drives researchers (both ideas, I suspect, will have a munificent effect on our current scientific culture).
Epigenetics: How Environment Shapes Our Genes by Richard C. Francis
agricultural Revolution, cellular automata, double helix, Drosophila, epigenetics, experimental subject, longitudinal study, Machine translation of "The spirit is willing, but the flesh is weak." to Russian and back, meta analysis, meta-analysis, phenotype, stem cell, twin studies
depression: in Dutch famine cohort gene mutation and maternal style and stress biasing and development cell division in cellular interactions in epigenesis theory of epigenetic processes in executive function in, see executive function feedback (reciprocal causation) in gene mutation and genetic-epigenetic program metaphor in preformationist theory of, see preformationism recipe/program metaphors in self-organizing processes in see also cellular differentiation developmental biology developmental genetics developmental origins hypothesis, see fetal programming developmental systems perspective devil facial tumor disease (DFTD) cellular stability of immune response and normalization and in tissue-based theory of cancer transmissibility of vaccine for diabetes: agouti alleles and in Dutch famine cohort gene mutation and genomic imprinting and GR expression and metabolic syndrome and stress biasing and diet, epigenetic inheritance and directorial intuition DNA base pairs in double helix structure of epigenetic modification of DNA histones and methylation of mutation of, x noncoding in protein synthesis DNA methyltransferases (Dnmt) dogs, cancer in donkeys dosage compensation see also X inactivation double helix Driesch, Hans Dutch famine multigenerational impact of Dutch Famine Birth Cohort Study birth weight in cardiovascular disease in diabetes in obesity in psychiatric disorders in timing of exposure as factor in egg cells, epigenetic attachments removed in production of egg fertilization embryonic cancers embryonic skin cells embryonic stem cells cancer and cellular interactions and controversy surrounding as pluripotent endocrine disruptors transgenerational effects of entelechy environment: epigenetic change as response to and epigenetic inheritance fetal, see fetal environment gene regulation effects of, as cell type-specific postnatal see also microenvironment, of cancer cells environmental toxins enzymes epialleles epigenesis epigenetic inheritance agouti locus and in Avy allele cancer and cardiovascular disease and diet and epigenetic reprogramming and olfaction and in plants randomness in RNA-based social inheritance as affected by epigenetic processes: asymmetry in cancer and definition of in gene regulation, see gene regulation, epigenetic as response to environment reversals of transgenerational, see transgenerational epigenetic processes and view of gene function in X inactivation epigenetic reprogramming epimutations epistasis erectile malfunctions, steroid abuse and estradiol estrogen receptors methylation of estrogens endocrine disruptor mimicking of evolutionary biology executive function: as residing in cells as residing in genes as residing in genome exons extracellular matrix eye color famine: epigenetic inheritance and see also Dutch famine; Dutch Famine Birth Cohort Study fast-food chains fat cells (adipose tissue): gene expression in melanin production in Faulkner, William fearfulness feedback (reciprocal causation) fertility drugs fertilization fetal development: IGF2 and maternal nutrition and fetal environment: epigenetic change as response to long-term health consequences of fetal environment mismatches between postnatal environment and nutrient availability in obesity and stress and true epigenetic inheritance and fetal programming fibroblast cells fight-or-flight response fish, effects of endocrine disruptors in folic acid autism and fruit flies fungicides FWA allele fwa mutation gene expression biparental vs. uniparental birth weight correlated with glucocorticoids and as inhibited by methylation monoallelic vs. biallelic mutation and, see mutation randomness and transcription factors in see also gene regulation gene regulation cancer and as cell type-specific executive function in, see executive function garden-variety (short-term) social interactions and gene regulation, epigenetic in development Driesch and as long-term methylation and, see methylation/demethylation microRNA and in plants as reversible stress biasing and war and Xist RNA and genes: activation of, see gene expression control panels of in executive cell view of gene regulation executive (traditional) view of imprinting control regions of inactive Janus metaphor of loci of methylation/demethylation of, see methylation/demethylation protein-coding sequence of traits as linked to see also alleles genetic background genetic code genetics: Mendelian modern, preformationism and genetic variation, immune response and genomic imprinting, see imprinting, genomic German army, in World War II glucocorticoid programming, see stress biasing glucocorticoid receptor gene, see GR gene glucocorticoid receptors (GR) glucocorticoid stress hormones glucose intolerance GnRH, see gonadotropin releasing hormone (GTRH) gonadotropin releasing hormone (GTRH) gonadotropins (GT) gonads genomic imprinting and melanin production in gorillas, socialization in GR gene methylation of growth: genomic imprinting and pathogen defense vs.
It is much more likely that the differences in Al and Bo are epigenetic in nature. The term epigenetic refers to long-term alterations of DNA that don’t involve changes in the DNA sequence itself. Either Al’s DNA was epigenetically altered in a way that meliorated his Kallmann syndrome, or Bo’s DNA was epigenetically altered in a way that exacerbated it. The naked gene consists of DNA in the form of the famous double helix. The genes in our cells are rarely naked, however. They are, rather, clothed in a variety of other organic molecules that are chemically attached. What makes these chemical attachments important is that they can alter the behavior of the genes to which they are attached; they can cause genes to be more or less active. What makes these attachments even more important is that they can stay attached for long periods of time, sometimes a lifetime.
Some proteins are enzymes that catalyze biochemical reactions, others serve to bind and transport essential elements and chemicals, and still others comprise the structural elements in muscles, skin, and cartilage. Somehow, these essential proteins must be made from DNA. But proteins come in multitudinous varieties while all DNA seemed similar. How then, were all of these proteins made from seemingly unvarying DNA? To answer this question, scientists had to take a closer look at DNA. It was discovered that the DNA molecule generally has two strands that coil in a helical fashion, the double helix. The “D” in DNA stands for the sugar deoxyribose (NA = nucleic acid). The deoxyribose sugar groups, each separated by a phosphate molecule, comprise the backbone of the DNA molecule. Attached to each sugar is a chemical called a base (as in basic, as opposed to acidic). The bases come in four varieties—adenine, cytosine, guanine, and thymine—which are generally denoted by their first letter: A, C, G, and T, respectively.
Reinventing Discovery: The New Era of Networked Science by Michael Nielsen
Albert Einstein, augmented reality, barriers to entry, bioinformatics, Cass Sunstein, Climategate, Climatic Research Unit, conceptual framework, dark matter, discovery of DNA, Donald Knuth, double helix, Douglas Engelbart, Douglas Engelbart, en.wikipedia.org, Erik Brynjolfsson, fault tolerance, Fellow of the Royal Society, Firefox, Freestyle chess, Galaxy Zoo, Internet Archive, invisible hand, Jane Jacobs, Jaron Lanier, Johannes Kepler, Kevin Kelly, Magellanic Cloud, means of production, medical residency, Nicholas Carr, P = NP, publish or perish, Richard Feynman, Richard Stallman, selection bias, semantic web, Silicon Valley, Silicon Valley startup, Simon Singh, Skype, slashdot, social intelligence, social web, statistical model, Stephen Hawking, Stewart Brand, Ted Nelson, The Death and Life of Great American Cities, The Nature of the Firm, The Wisdom of Crowds, University of East Anglia, Vannevar Bush, Vernor Vinge
As you know, inside each of the cells in your body are many strands of the DNA molecule. Those strands of DNA carry information, and the information they carry is the design for you. To understand how DNA carries this information, recall the double helix structure of DNA. The helices are beautiful and memorable, but the information isn’t stored in the helices, per se. Rather, it is stored in between the helices. Every few nanometers as you move up the double helix there is a pair of molecules joining the two sides of the helix, called a base pair. It’s a pair of special little mini-molecules that bond to one another, and to the backbones of the double helix. There are four types of base molecule, called adenine, cytosine, guanine, and thymine. Their names are usually just shortened to A, C, G, and T. The A bonds to the T and the C to the G, so the possible pairs are A-T and C-G.
To their astonishment, they quickly realized that Pauling was wrong: the world’s greatest chemist had made a simple mistake in basic chemistry, a mistake his own textbooks should have alerted him to. Watson and Crick went back to their work with renewed intensity, and soon after found the right structure. When that happened it didn’t matter that Pauling was world famous while Watson, Crick, and Franklin were unknowns. The scientific community rejected Pauling’s work, and hailed the double helix as one of the scientific discoveries of the century. The examples of Einstein and of Watson, Crick, and Franklin illustrate the strength of the shared praxis in science. To an extent unusual in many parts of life, in science it’s often the person with the best evidence and best arguments who wins out, and not the person with the biggest reputation and the most power. Pauling may have been widely acknowledged as the world’s leading chemist, but other chemists could see just as surely as Watson and Crick that Pauling’s structure was simply wrong.
p 79: Regarding the rapid acceptance of Einstein’s ideas, it helped that leading scientists such as Lorentz and Poincaré arrived at similar conclusions at about the same time. But although Einstein’s formulation of relativity was even more radical than the formulations of Lorentz and Poincaré, it quickly became accepted as the correct way to think about relativity. p 79: On the discovery of DNA, and Pauling’s error, see Watson’s memoir, The Double Helix . p 80 “If Feynman says it three times, it’s right”: . p 84: My thanks to Mark Tovey for help constructing this example on optical illusions and cognitive science. p 85: On collaboration markets, see also  and . p 85: The discussion of topological quantum computes is inspired by . Topological quantum computers were originally proposed in a remarkable article by Kitaev .
Power, Sex, Suicide: Mitochondria and the Meaning of Life by Nick Lane
Benoit Mandelbrot, clockwork universe, double helix, Drosophila, Geoffrey West, Santa Fe Institute, Louis Pasteur, mandelbrot fractal, out of africa, phenotype, random walk, Richard Feynman, stem cell, unbiased observer
The histones not only protect eukaryotic DNA from chemical attack, but also guard access to the genes. When he discovered the structure of DNA, Francis Crick immediately understood how genetic inheritance works, announcing in the pub that evening that he understood the secret of life. DNA is a template, both for itself and for proteins. The two entwined strands of the double helix each act as a template for the other, so that when they are prized apart, during cell division, each strand provides the information necessary for reconstituting the full double helix, giving two identical copies. The information encoded in DNA spells out the molecular structure of proteins. This, said Crick, is the ‘central dogma’ of all biology: genes code for proteins. The long ticker tape of DNA is a seemingly endless sequence of just four molecular ‘letters’, just as all our words, all our books, are a sequence of only 26 letters.
Despite its obvious importance to life, biological energy receives far less attention than it deserves. According to molecular biologists, life is all about information. Information is encoded in the genes, which spell out the instructions for building proteins, cells, and bodies. The double helix of DNA, the stuff of genes, is an icon of our information age, and the discoverers of its structure, Watson and Crick, are household names. The reasons for this status are a mixture of the personal, the practical, and the symbolic. Crick and Watson were brilliant and ﬂamboyant, and unveiled the structure of DNA with the aplomb of conjurors. Watson’s famous book narrating the discovery, The Double Helix, deﬁned a generation and changed the way that science is perceived by the general public; and he has been an outspoken and passionate advocate of genetic research ever since. In practical terms, sequencing the codes of genes enables us to compare ourselves with other organisms and to peer into our own past, as well as the story of life.
Unlike Watson and Crick, Mitchell was an eccentric and reclusive genius, who set up his own laboratory in an old country house in Cornwall, which he had renovated himself, following his own designs. At one time, his research was funded in part by the proceeds from a herd of dairy cows, and he even won a prize for the quality of his cream. His writings did not compete with Watson’s Double Helix—besides the usual run of dry academic papers (even more obscure than usual in Mitchell’s own case), he expounded his theories in two ‘little grey books’, published privately and circulated among a few interested professionals. His ideas can’t be encapsulated in a visually arresting emblem like the double helix, redolent of the standing of science in society. Yet Mitchell was largely responsible for articulating and proving one of the very greatest insights in biology, a genuine and bizarre revolution that overturned long-cherished ideas. As the eminent molecular biologist Leslie Orgel put it: ‘Not since Darwin has biology come up with an idea as counterintuitive as those of, say, Einstein, Heisenberg or Schrödinger. . . his contemporaries might well have asked “Are you serious, Dr Mitchell?”’
The Rise and Fall of Modern Medicine by M. D. James le Fanu M. D.
Barry Marshall: ulcers, clean water, cuban missile crisis, discovery of penicillin, double helix, experimental subject, Gary Taubes, Isaac Newton, lateral thinking, meta analysis, meta-analysis, rising living standards, selective serotonin reuptake inhibitor (SSRI), stem cell, telerobotics, The Design of Experiments, the scientific method, V2 rocket
But we have moved, in the light of these extraordinary findings, from supposing those instructions are at least knowable in principle to recognizing that we have no conception what they might be. It might seem pointless to enquire why this might be so, but the explanation must lie at least in part in the simple elegance of the two intertwining strands of the double helix, which for so long has held out the promise that it might be possible to understand ‘the secret of life’. That simple elegance cannot be because the double helix is simple, but because it has to be simple, if it is to copy the genetic material every time the cell divides.24 And that obligation to be simple requires the double helix to condense within the one-dimensional sequence of the CGAT chemicals of the genes strung out along the two intertwining strands the billion-fold biological complexities of the three-dimensional forms and attributes that so readily distinguish one form of life from another – flies from worms from frogs from humans.
The only way to try and come to a balanced judgement is to trace the evolution of the principal ideas over the last twenty-five years and then examine the record of its three practical applications to medicine: Genetic Engineering as a method of developing new drugs; Genetic Screening as a means of eradicating inherited disease; and Gene Therapy for the correction of genetic defects. We begin with a preamble describing how the genes work, elucidated for greater clarity by reference to the schematic diagram on page 314. This starts in 1953, when James Watson and Francis Crick famously discovered the structure of DNA to be a spiral staircase (or double helix).2 The two outer ‘banisters’ of the staircase are made up of two strands of sugar molecules – Deoxyribose – from each of which is suspended a parallel series of four types of molecule known as Nucleic Acids – Adenine, Guanine, Cytosine and Thymine (referred to by their initials AGCT) – arranged in sequence. The chemical bonds linking the two parallel chains of nucleic acids form the ‘steps’ of the staircase.
The profound significance of this ‘staircase structure’ is that it is particularly well suited to the replication of genetic information every time the cell divides, as Watson and Crick described: We imagine that, prior to duplication, the bonds [connecting the two parallel chains of nucleic acids or ‘nucleotides’] are broken and the two chains unwind and separate [the staircase, as it were, splits down the middle]. Each chain then acts as a template for the formation on to itself of a new companion chain, so that eventually we shall have two pairs of chains where we only had one before. Moreover the sequence of the pairs of nucleotides will have been duplicated exactly.3 The double helix of DNA consists of two parallel strands of deoxyribose sugar molecules, to which are attached a sequence of nucleotides – AGCT – arranged in threes. The genetic instruction for a protein is conveyed by a strand of messenger RNA (mRNA) that passes out of the nucleus into the cytoplasm, where it feeds its coded instructions into a ribosome or protein factory. Next it is necessary to clarify the manner in which the nucleic acids (or nucleotides) form the ‘genes’ that code for the tens of thousands of different proteins (enzymes, hormones, etc.).
Where Good Ideas Come from: The Natural History of Innovation by Steven Johnson
Ada Lovelace, Albert Einstein, Alfred Russel Wallace, carbon-based life, Cass Sunstein, cleantech, complexity theory, conceptual framework, cosmic microwave background, creative destruction, crowdsourcing, data acquisition, digital Maoism, digital map, discovery of DNA, Dmitri Mendeleev, double entry bookkeeping, double helix, Douglas Engelbart, Douglas Engelbart, Drosophila, Edmond Halley, Edward Lloyd's coffeehouse, Ernest Rutherford, Geoffrey West, Santa Fe Institute, greed is good, Hans Lippershey, Henri Poincaré, hive mind, Howard Rheingold, hypertext link, invention of air conditioning, invention of movable type, invention of the printing press, invention of the telephone, Isaac Newton, Islamic Golden Age, James Hargreaves, James Watt: steam engine, Jane Jacobs, Jaron Lanier, Johannes Kepler, John Snow's cholera map, Joseph Schumpeter, Joseph-Marie Jacquard, Kevin Kelly, lone genius, Louis Daguerre, Louis Pasteur, Mason jar, mass immigration, Mercator projection, On the Revolutions of the Heavenly Spheres, online collectivism, packet switching, PageRank, patent troll, pattern recognition, price mechanism, profit motive, Ray Oldenburg, Richard Florida, Richard Thaler, Ronald Reagan, side project, Silicon Valley, silicon-based life, six sigma, Solar eclipse in 1919, spinning jenny, Steve Jobs, Steve Wozniak, Stewart Brand, The Death and Life of Great American Cities, The Great Good Place, The Wisdom of Crowds, Thomas Kuhn: the structure of scientific revolutions, transaction costs, urban planning
EARLY LIFE SIMULATED (1953) In an effort to understand the conditions governing early life on earth, American chemist Stanley Miller and American physical chemist Harold Urey created a closed system, including the elements they believed were present in earth’s early atmosphere such as hydrogen, methane, and water. Miller and Urey discovered that amino acids could be easily produced under such conditions. DOUBLE HELIX (1953) Drawing on previous studies of nucleotides in DNA, American molecular biologist James D. Watson and British molecular biologist Francis Crick experimented with models of different combinations of nucleotides using paper and wire, and eventually settled upon the intertwined, dual, nucleotide strands that we now recognize as the double helix. VCR (1956) The invention of the VCR, or video cassette recorder, is generally attributed to the American engineer Charles Paulson Ginsburg, who developed the device while at the Ampex Corporation by applying high-frequency signals onto magnetic tape.
Without that link, he would have been merely a pioneering typesetter, making an incremental improvement on Pi Sheng’s movable type. By not restricting himself exclusively to the island of metallurgy, he became something much more important: a printer. The model of weak-tie exaptation also helps us understand the classic story of twentieth-century scientific epiphany: Watson and Crick’s discovery of the double-helix structure of DNA. As Ogle and others have noted, in the small scientific community working on the problem of DNA in the early 1950s, the person who had the clearest and most direct view of the molecule itself was neither James Watson nor Francis Crick. It was, instead, a biophysicist at London University named Rosalind Franklin, who was using state-of-the-art X-ray crystallography to study the mysterious strands of DNA.
First, there was the imperfect state of the X-ray technology, which only gave her hints about the helix structure and base-pair symmetry. But Franklin was also limited by the conceptual island on which she based her work. Her approach was purely inductive: master the X-ray technology and then use the information collected to build a model of DNA. (“We’re going to let the data tell us the structure,” she famously told Crick.) But to “see” the double-helix in the early 1950s took something more than just analyzing it in an X-ray machine. To solve the mystery, Watson and Crick had to piece it together with tools drawn from multiple disciplines: biochemistry, genetics, information theory, and mathematics, not to mention Franklin’s X-ray images. Even Crick’s sculpture metaphor proved crucial to cracking the code. Next to Franklin, Watson and Crick seemed almost dilettantes and dabblers: Crick had switched from physics to biology in his graduate years; neither had a comprehensive grasp of biochemistry.
Unweaving the Rainbow by Richard Dawkins
Any sufficiently advanced technology is indistinguishable from magic, Arthur Eddington, complexity theory, correlation coefficient, David Attenborough, discovery of DNA, double helix, Douglas Engelbart, Douglas Engelbart, I think there is a world market for maybe five computers, Isaac Newton, Jaron Lanier, Mahatma Gandhi, music of the spheres, Necker cube, p-value, phenotype, Ralph Waldo Emerson, Richard Feynman, Ronald Reagan, Solar eclipse in 1919, Steven Pinker, Zipf's Law
Sophisticated theologians who do not literally believe in the Virgin Birth, the Six Day Creation, the Miracles, the Transubstantiation or the Easter Resurrection are nevertheless fond of dreaming up what these events might symbolically mean. It is as if the double helix model of DNA were one day to be disproved and scientists, instead of accepting that they had simply got it wrong, sought desperately for a symbolic meaning so deep as to transcend mere factual refutation. 'Of course,' one can hear them saying, 'we don't literally believe factually in the double helix any more. That would indeed be crudely simplistic. It was a story that was right for its own time, but we've moved on. Today, the double helix has a new meaning for us. The compatibility of guanine with cytosine, the glove-like fit of adenine with thymine, and especially the intimate mutual twining of the left spiral around the right, all speak to us of loving, caring, nurturing relationships...'
The compatibility of guanine with cytosine, the glove-like fit of adenine with thymine, and especially the intimate mutual twining of the left spiral around the right, all speak to us of loving, caring, nurturing relationships...' Well, I'd be surprised if it quite came to that, and not only because the double helix model is now very unlikely to be disproved. But in science, as in any other field, there really are dangers of becoming intoxicated by symbolism, by meaningless resemblances, and led farther and farther from the truth, rather than towards it. Steven Pinker reports that he is troubled by correspondents who have discovered that everything in the universe comes in threes: the Father, the Son, and the Holy Ghost; protons, neutrons and electrons; masculine, feminine and neuter; Huey, Dewey, and Louie; and so on, for page after page. How the Mind Works (1998) Slightly more seriously, Sir Peter Medawar, the distinguished British zoologist and polymath whom I quoted before, invents a great new universal principle of complementarity (not Bohr's) according to which there is an essential inner similarity in the relationships that hold between antigen and antibody, male and female, electropositive and electronegative, thesis and antithesis, and so on.
Gould is aware of the difference between rapid gradualism and macromutation, but he treats the matter as though it were a minor detail, to be cleared up after we have taken on board the overarching question of whether evolution is episodic rather than gradual. One can see it as overarching only if one is intoxicated by bad poetry. It makes as little sense as my correspondent's question about the DNA double helix and whether it 'comes from' the earth's orbit. Once again, rapid gradualism no more resembles macromutation than a bleeding wizard resembles a shower of rain. Even worse is to claim catastrophism under the same punctuationist umbrella. In pre-Darwinian times the existence of fossils became increasingly embarrassing for upholders of biblical creation. Some hoped to drown the problem in Noah's flood, but why did the strata seem to show dramatic replacements of whole faunas, each one different from its predecessor, and all of them largely free of our own, familiar creatures?
The Scientist as Rebel by Freeman Dyson
Albert Einstein, Asilomar, British Empire, Claude Shannon: information theory, dark matter, double helix, Edmond Halley, Ernest Rutherford, experimental subject, Fellow of the Royal Society, From Mathematics to the Technologies of Life and Death, Henri Poincaré, Isaac Newton, Johannes Kepler, John von Neumann, kremlinology, Mikhail Gorbachev, Norbert Wiener, Paul Erdős, Richard Feynman, Ronald Reagan, Silicon Valley, Stephen Hawking, Thomas Kuhn: the structure of scientific revolutions, traveling salesman, undersea cable
One was the discovery of the double-helix structure of DNA, the other was the discovery of the triple-helix structure of the collagen molecule. Both molecules are biologically important, DNA being the carrier of genetic information, collagen being the protein that holds human bodies together. The two discoveries involved similar scientific techniques and aroused similar competitive passions in the scientists racing to be the first to find the structure. Crick says that the two discoveries caused him equal excitement and equal pleasure at the time he was working on them. From the point of view of a historian who believes that science is a purely social construction, the two discoveries should have been equally significant. But in history as Crick experienced it, the two helixes were not equal. The double helix became the driving force of a new science, while the triple helix remained a footnote of interest only to specialists.
The double helix became the driving force of a new science, while the triple helix remained a footnote of interest only to specialists. Crick asks the question, how the different fates of the two helixes are to be explained. He answers the question by saying that human and social influences cannot explain the difference, that only the transcendent beauty of the double-helix structure and its genetic function can explain the difference. Nature herself, and not the scientist, decided what was important. In the history of the double helix, transcendence was real. Crick gives himself the credit for choosing an important problem to work on, but, he says, only Nature herself could tell how transcendentally important it would turn out to be. My message is that science is a human activity, and the best way to understand it is to understand the individual human beings who practice it.
Bernal was himself one of the founding fathers of molecular biology. In the 1930s he mastered the art of mapping the structure of large molecules by means of X-rays. He understood that this art would be the key to the understanding of the physical basis of life. His pioneering work led directly to the discovery of the double helix in 1953. Rosalind Franklin, who took the crucial X-ray pictures of DNA that showed the helical structure, was working in Bernal’s laboratory in London. In the 1968 foreword to his book, Bernal speaks of the double helix as “the greatest and most comprehensive idea in all science.” As a result of this discovery, we understand the basic principles by which living cells organize and reproduce themselves. Many mysteries remain, but it is inevitable that we shall understand the chemical processes of life in full detail, including the processes of development and differentiation of higher organisms, within the next century.
The Cancer Chronicles: Unlocking Medicine's Deepest Mystery by George Johnson
Atul Gawande, Cepheid variable, Columbine, dark matter, discovery of DNA, double helix, Drosophila, epigenetics, Gary Taubes, Harvard Computers: women astronomers, Isaac Newton, Magellanic Cloud, meta analysis, meta-analysis, microbiome, mouse model, Murray Gell-Mann, phenotype, profit motive, stem cell
…A curious law of nature … Contemplating the odds CHAPTER 2 Nancy’s Story Food pyramidology … Pascal’s wager … Folates, antioxidants, and Finnish smokers … Fruits, vegetables, and giant steaks … Carcinogenic estrogen … The real risks of cigarettes … Emanations from the earth … Cancer clusters … A worrisome lump … Nancy’s cancer CHAPTER 3 The Consolations of Anthropology In the boneyards of Kenya … Face-to-face with Kanam man…Palaeo-Oncology…Hippocrates and the crabs … The wild beast of cancer … Metastasis in a Scythian king … Skeletons and mummies … Visions of an ancient paradise … Counting up the dead CHAPTER 4 Invasion of the Body Snatchers “Large and beautifully pellucid cells”…Morbid juices … Seeds and soil … The mysteries of metastasis … A horrifying precision … The ebb and flow of lymph … The surgeon’s diagnosis … Weeds from outer space CHAPTER 5 Information Sickness Man-made mutations … Funny-looking chromosomes…“A new kind of cell”…Matter that comes alive … The Radium Girls … Coal tar and tumors … Viral invaders … Oncogenes and tumor suppressors … Cellular suicide … Intimations of immortality … A conspiracy of cells CHAPTER 6 “How Heart Cells Embrace Their Fate” Embryos and tumors … Snail, slug, and twist … Sonic hedgehog … the Pokémon gene … Cyclopean sheep … Holoprosencephaly … 1 + 1 = 3 … Prayers of an agnostic … An endless day at the hospital CHAPTER 7 Where Cancer Really Comes From The surprising aftermath of Love Canal … What “environment” really means…“The Causes of Cancer”…An environmental turncoat … The carcinogens in coffee … Mitogenesis and mutagenesis … Making sense of the cancer statistics … A maverick presidential report CHAPTER 8 “Adriamycin and Posole for Christmas Eve” Cancer cells and magnets … The penicillin of cancer … A rare kind of malignancy … Disheartening statistics…“The Median Isn’t the Message”…Flying farolitos … A visit to MD Anderson … Rothko’s brooding chapel CHAPTER 9 Deeper into the Cancer Cell A physics of cancer … Epigenetic software … The stem cell conundrum … An enormous meeting in Orlando … Espresso and angiogenesis … The news from Oz.…Communing with the microbiome … Beyond the double helix … Dancing at the Cancer Ball CHAPTER 10 The Metabolic Mess Chimney sweeps and nuns … A “mysterious sympathy”…The case of the missing carcinogens … The rise and fall of vegetables … A mammoth investigation … The insulin-obesity connection…“Wounds that do not heal”…A hundred pounds of sugar … Skewing the energy equation CHAPTER 11 Gambling with Radiation Flunking the radon test … A ubiquitous carcinogen … Down in the uranium mines … Tourism at Chernobyl … Hiroshima and Nagasaki … Exhuming Curie’s grave … A pocketful of radium … Robot oncologists … Relay for Life CHAPTER 12 The Immortal Demon A flight to Boston … Stand Up to Cancer … A tale of two cousins … The return of the hedgehog … Where weird drug names come from … Waiting for super trastuzumab … Orphaned cancers … Biological game theory … Contagious cancer CHAPTER 13 Beware the Echthroi On Microwave Mountain … Cell phones and brain waves … Is cancer here “on purpose”?
This was long before DNA was identified as the stuff of genes, the helically shaped molecule that carries genetic information in a four-symbol alphabet—the nucleotides abbreviated G, C, A, and T. If a letter is changed, the meaning can be corrupted. The signal becomes noise or is silenced altogether. That kind of clarity would come decades later with the discoveries of Oswald Avery in 1944, Alfred Hershey and Martha Chase in 1952, and a year later when James Watson and Francis Crick cobbled together from cardboard, sheet metal, and wire their model of the double helix. For now Muller’s contribution was to show that whatever genes were made of and however they worked, you didn’t have to wait for mutations to occur. They could be produced at will by exposing the flies to x-rays. Most often the mutations sterilized the flies or killed them. That, he speculated, might explain why the rays were so effective at destroying rapidly dividing cancer cells—a therapy that had come into use almost as soon as x-rays were first produced in the laboratory of Wilhelm Röntgen in 1895.
One of them, p53, sits at the center of a web of chemical pathways controlling the life cycle of a cell. If you want to start a cancer, take down p53. If a cell is damaged and dividing too quickly, external sensors will pick up warning signals from crowded neighbors. Internal sensors will detect chemical imbalances or broken DNA. With an emergency declared, p53 will step in and slow down the clock so that DNA repair can take place. Proofreading enzymes scan the genome. If one strand of DNA’s double helix has been corrupted, the other strand can be used as a template to guide repair. Damaged sections can be excised, a replacement synthesized and put into place. If DNA repair is broken and other measures cannot save a cell that is mutating beyond control, p53 initiates programmed cell death, or apoptosis. The name is derived from a Greek word describing falling leaves. When an embryo is developing into a little body, it will produce far more cells than it needs.
Woolly: The True Story of the Quest to Revive History's Most Iconic Extinct Creature by Ben Mezrich
butterfly effect, Danny Hillis, double helix, Electric Kool-Aid Acid Test, Jeff Bezos, Kickstarter, life extension, Louis Pasteur, mass immigration, microbiome, personalized medicine, Peter Thiel, Silicon Valley, Silicon Valley ideology, stem cell, Stewart Brand
After finding an ignored computer in the basement of the science building, he’d taught himself to program and done a bit of hacking just to see if he could. By the end of his second year, his teachers recognized that he was different, and, eventually, they gave him keys to the various labs, so he could conduct his independent projects on his own. At Andover, he first discovered the world of genetics. He was fascinated by the fact that every living cell had within it a genomic code—a double helix of DNA made up of bases of chemical molecules attached together like rungs on a ladder. And that ladder comprised coding for everything, from eye color to the length of fingers and toes. At the time, the study of genetics was in its infancy, and it was the dirty stepchild of the biological field. People who wanted to change the world didn’t go into genetics; they found other avenues for making significant contributions.
At his interview, he pitched his Ph.D. thesis, a dissertation about a new method of analyzing genetic enhancers that were involved in DNA-binding. It was just sexy enough to get him the post, but what he truly wanted to work on was sequencing—coming up with ways to read genetic material fast, better, and cheaper. At the time, the art of reading genomes was just being developed, although James D. Watson and Francis Crick had discovered and defined the double helix structure of DNA as far back as 1953. It was now well known that genetic material is formed by billions of organic molecules called nucleotides (the basic units of nucleic acid that make up DNA and RNA). These are arranged in sequences that create the genome, which is carried by every living cell in every living organism, and in which all traits are coded. But isolating and “reading” those sequences was still extremely difficult.
Over the past few months, he had tried to come up with simple ways to explain what was essentially now the primary tool in genetic engineering. With high school students, he started with the basics. Every cell in every living creature contained a copy of the creature’s genome—the double strands of DNA, made up of billions of base pairs of molecules, that coded for every trait or characteristic that made the creature what it was. Those double strands, known as the double helix, the discovery made by James Watson, Francis Crick, and Rosalind Franklin in the fifties, were connected in pairs of chemical bases: the chemical adenine paired with thymine (A-T) and the chemical cytosine paired with guanine (C-G). Simple bacteria had developed a natural system to protect their own genomes—their double strands of DNA—from attacks by viruses. To defend themselves, they employed a protein called Cas 9 that could act like a molecular pair of scissors.
As the Future Catches You: How Genomics & Other Forces Are Changing Your Work, Health & Wealth by Juan Enriquez
Albert Einstein, Berlin Wall, bioinformatics, borderless world, British Empire, Buckminster Fuller, business cycle, creative destruction, double helix, global village, half of the world's population has never made a phone call, Howard Rheingold, Jeff Bezos, Joseph Schumpeter, Kevin Kelly, knowledge economy, more computing power than Apollo, new economy, personalized medicine, purchasing power parity, Ray Kurzweil, Richard Feynman, Robert Metcalfe, Search for Extraterrestrial Intelligence, SETI@home, Silicon Valley, spice trade, stem cell, the new new thing
You rarely see bioinformaticians … They are too valuable to companies and universities. Things are moving too fast … And they are too passionate about what they do … To spend a lot of time giving speeches and interviews. But if you go into the bowels of Harvard Medical School … And are able to find the genetics department inside the Warren Alpert Building … (A significant test of intelligence in and of itself … Start by finding the staircase inspired by the double helix … and go past the bathrooms marked XX and XY …) There you can find a small den where George Church hangs out, surrounded by computers. He seems like a large teddy bear … Often hiding his extraordinary brain behind a quiet grin, a beard, and a self-effacing manner. This is ground zero for a wonderful commune of engineers, physicists, molecular biologists, and physicians …3 And some of the world’s smartest graduate students … Who are trying to make sense of the 100 terabytes of data that come out of gene labs yearly … A task equivalent to trying to sort and use a million new encyclopedias … every year.4 You can’t build enough “wet” labs (labs full of beakers, cells, chemicals, refrigerators) to process and investigate all the opportunities this scale of data generates.
The article concludes with one of the great understatements in the history of science: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” You can read the original paper: http://biocrs.biomed.brown.edu/Books/Chapters/Ch%208/DH-Paper.html. You might also want to look at Watson’s opinionated, short, and controversial The Double Helix (New York: Atheneum, 1968). 9. Time set up a fun page that profiles their picks for the top 100 scientists: www. time.com/time/time100/scientist/index.html. 10. And when you want to translate gene code into proteins, you have to be even more careful. Careless translations bring many pitfalls. Cantonese smile when they hear the words “Mercedes-Benz,” because it can sound like “so clumsy, you die.” 11.
Sjolander, Brian Karlak, Anish Kejariwal, Huaiyu Mi, Betty Lazareva, Thomas Hatton, Apurva Narechania, Karen Diemer, Anushya Muruganujan, Nan Guo, Shinji Sato, Vineet Bafna, Sorin Istrail, Ross Lippert, Russell Schwartz, Brian Walenz, Shibu Yooseph, David Allen, Anand Basu, James Baxendale, Louis Blick, Marcelo Caminha, John Carnes-Stine, Parris Caulk, Yen-Hui Chiang, My Coyne, Carl Dahlke, Anne Deslattes Mays, Maria Dombroski, Michael Donnelly, Dale Ely, Shiva Esparham, Carl Fosler, Harold Gire, Stephen Glanowski, Kenneth Glasser, Anna Glodek, Mark Gorokhov, Ken Graham, Barry Gropman, Michael Harris, Jeremy Heil, Scott Henderson, Jeffrey Hoover, Donald Jennings, Catherine Jordan, James Jordan, John Kasha, Leonid Kagan, Cheryl Kraft, Alexander Levitsky, Mark Lewis, Xiangjun Liu, John Lopez, Daniel Ma, William Majoros, Joe McDaniel, Sean Murphy, Matthew Newman, Trung Nguyen, Ngoc Nguyen, Marc Nodell, Sue Pan, Jim Peck, Marshall Peterson, William Rowe, Robert Sanders, John Scott, Michael Simpson, Thomas Smith, Arlan Sprague, Timothy Stockwell, Russell Turner, Eli Venter, Mei Wang, Meiyuan Wen, David Wu, Mitchell Wu, Ashley Xia, Ali Zandieh, Xiaohong Zhul, “The Sequence of the Human Genome,” Science 291 (February 16, 2001): 1304–51. The International Human Genome Sequencing Consortium also matched this extraordinary achievement with a different version of the genome published the same week: see Nature 409 (2001) … Got a lot of time on your hands and want to play Where’s Waldo? Take a look at the hundreds of photographs that form the double helix on the cover of Nature and find the one of Watson and Crick. 12. Reported in The New York Times based on data from Dr. Mani Subramanian from Celera. Chart does not include 5.1 percent miscellaneous genes. 13. The experiments occurred during 1998 and 1999 but were not reported until February 2001 out of fear that rogue states might use the data to create a vaccine-resistant smallpox. Ronald J.
The Ancestor's Tale: A Pilgrimage to the Dawn of Evolution by Richard Dawkins
agricultural Revolution, Alfred Russel Wallace, complexity theory, delayed gratification, double helix, Drosophila, Haight Ashbury, invention of writing, lateral thinking, Louis Pasteur, mass immigration, nuclear winter, out of africa, Peter Singer: altruism, phenotype, Richard Feynman, Ronald Reagan, Spread Networks laid a new fibre optics cable between New York and Chicago, Steven Pinker, the High Line, urban sprawl
This is because, unlike proteins with their near infinite variety of three-dimensional shapes, DNA has only one shape, the famous double helix itself. The double helix is ideally suited to replication because the two sides of the stairway peel easily away from one another, each being then exposed as a template for new letters to join, following the Watson-Crick pairing rules. It is not much good for anything else. RNA has some of the virtues of DNA as a replicator and some of the virtues of protein as a versatile shaper of enzymes. The four letters of RNA are sufficiently similar to the four letters of DNA that either set can serve as a template for the other. On the other hand, RNA does not easily form a long double helix, which means that it is somewhat inferior to DNA as a replicator. This is partly because the double helix system lends itself to proof-correction. When the DNA double helix splits and each single helix immediately serves as a template for its complement, errors can instantly be spotted, and corrected.
Computer graphic of transfer RNA, paired with itself to make a miniature double helix. But the lack of a double helix structure has its upside as well as its downside. Because the RNA chain doesn't spend all its time paired with its complementary chain but breaks away from the complement as soon as it is formed, it is free to tie itself in knots like a protein. Just as the protein does it by virtue of the chemical affinities of amino acids for other amino acids in different parts of the same chain, RNA does it using the ordinary Watson-Crick base-pairing rules, the same ones as are used to make copies of RNA. Putting it another way, lacking a partner chain to pair with in a double helix like DNA, RNA is free to 'pair' with odd bits of itself. RNA finds small stretches of itself with which it can pair, either in a miniature double helix or in some other shape.
A story is whispered to the first child, who whispers it to the second, and so on until the last child, whose finally revealed version of the story turns out to be an amusingly garbled and degraded version of the original. * 'Redundant' is sometimes mistakenly used instead of degenerate, but it means something different. The genetic code is, as it happens, redundant too. in that either strand of the double helix could be decoded to yield the same information. Only one of them is actually decoded, but the other is used for correcting errors. Engineers, too, use redundancy -- repetitiousness --to correct errors. The degeneracy of the genetic code is something different, and it is what we are talking about here. A degenerate code contains synonyms and could therefore accommodate a larger range of meanings than it actually does.
A Devil's Chaplain: Selected Writings by Richard Dawkins
Albert Einstein, Alfred Russel Wallace, Buckminster Fuller, butterfly effect, Claude Shannon: information theory, complexity theory, Desert Island Discs, double helix, Douglas Hofstadter, epigenetics, experimental subject, Fellow of the Royal Society, gravity well, Necker cube, out of africa, phenotype, placebo effect, random walk, Richard Feynman, Silicon Valley, stem cell, Stephen Hawking, the scientific method
It is simply true that the Sun is hotter than the Earth, true that the desk on which I am writing is made of wood. These are not hypotheses awaiting falsification; not temporary approximations to an ever-elusive truth; not local truths that might be denied in another culture. And the same can safely be said of many scientific truths, even where we can’t see them ‘with our own eyes’. It is forever true that DNA is a double helix, true that if you and a chimpanzee (or an octopus or a kangaroo) trace your ancestors back far enough you will eventually hit a shared ancestor. To a pedant, these are still hypotheses which might be falsified tomorrow. But they never will be. Strictly, the truth that there were no human beings in the Jurassic Period is still a conjecture, which could be refuted at any time by the discovery of a single fossil, authentically dated by a battery of radiometric methods.
So a crystal may grow in solution from a tiny ‘seed’ – perhaps an impurity like the sand grain at the heart of a pearl. There is no grand design of buckyballs, quartz crystals, diamonds or anything else. This principle of self-assembly runs right through living structure, too. DNA itself (the genetic molecule, the molecule at the centre of all life) can be regarded as a long, spiral crystal in which one half of the double helix self-assembles on a template provided by the other. Viruses self-assemble like elaborately complex crystal-clusters. The head of the T4 bacteriophage (a virus that infects bacteria) actually looks like a single crystal. Go into any museum and look at the collection of minerals. Even go into a New Age shop and look at the crystals on display, along with all the other apparatus of mumbo-jumbo and kitsch con-trickery.
Females have two X chomosomes, one from each parent. A male shares X chromosome genes with his maternal, but not his paternal, uncle. 2 This distinction was also used in ‘Darwin Triumphant’ (p. 104). 2.5 Son of Moore’s Law70 Great achievers who have gone far sometimes amuse themselves by then going too far. Peter Medawar knew what he was doing when he wrote, in his review of James D. Watson’s The Double Helix, It is simply not worth arguing with anyone so obtuse as not to realize that this complex of discoveries [molecular genetics] is the greatest achievement of science in the twentieth century. Medawar, like the author of the book he was reviewing, could justify his arrogance in spades, but you don’t have to be obtuse to dissent from his opinion. What about that earlier Anglo-American complex of discoveries known as the Neo-Darwinian Modern Synthesis?
Too Big to Know: Rethinking Knowledge Now That the Facts Aren't the Facts, Experts Are Everywhere, and the Smartest Person in the Room Is the Room by David Weinberger
airport security, Alfred Russel Wallace, Amazon Mechanical Turk, Berlin Wall, Black Swan, book scanning, Cass Sunstein, commoditize, corporate social responsibility, crowdsourcing, Danny Hillis, David Brooks, Debian, double entry bookkeeping, double helix, en.wikipedia.org, Exxon Valdez, Fall of the Berlin Wall, future of journalism, Galaxy Zoo, Hacker Ethic, Haight Ashbury, hive mind, Howard Rheingold, invention of the telegraph, jimmy wales, Johannes Kepler, John Harrison: Longitude, Kevin Kelly, linked data, Netflix Prize, New Journalism, Nicholas Carr, Norbert Wiener, openstreetmap, P = NP, Pluto: dwarf planet, profit motive, Ralph Waldo Emerson, RAND corporation, Ray Kurzweil, Republic of Letters, RFID, Richard Feynman, Ronald Reagan, semantic web, slashdot, social graph, Steven Pinker, Stewart Brand, technological singularity, Ted Nelson, the scientific method, The Wisdom of Crowds, Thomas Kuhn: the structure of scientific revolutions, Thomas Malthus, Whole Earth Catalog, X Prize
Johannes Kepler examined the star charts carefully constructed by his boss, Tycho Brahe, until he realized in 1605 that if the planets orbit the Sun in ellipses rather than perfect circles, it all makes simple sense. Three hundred fifty years later, James Watson and Francis Crick stared at x-rays of DNA until they realized that if the molecule were a double helix, the data about the distances among its atoms made simple sense. With these discoveries, the data went from being confoundingly random to revealing an order that we understand: Oh, the orbits are elliptical! Oh, the molecule is a double helix! With the new database-based science, there is often no moment when the complex becomes simple enough for us to understand it. The model does not reduce to an equation that lets us then throw away the model. You have to run the simulation to see what emerges. For example, Eric Bonabeau, an expert in models of this sort, suggests a simple game.
Kuhn argued that science was not simply a progressive march of discoveries that build on prior hard-won discoveries, bringing us ever closer to the truth. Rather, it turns out that the questions science asks, the facts it takes as relevant, and the explanations it gives all occur within an overarching scientific “paradigm” such as Aristotelian, Newtonian, or Einsteinian physics. Simple truths appear—and are relevant—only within complex, historical systems of thought, institutions, and equipment. • In 1968, James Watson published The Double Helix, an account of his and Francis Crick’s discovery of the structure of DNA. This highly readable account scandalized many because it revealed that scientists are governed by personal ambition as well as by a desire to find the truth. Many accounts since then confirmed that there is a psychology and sociology of science. For example, in And the Band Played On, Randy Shilts recounts the shameful delays in the discovery of the retrovirus that causes AIDS due to rivalries among labs and government agencies
See Science at Creative Commons Crick, Francis Crisis of knowledge CrisisCommons.org Crowds Crowdsourcing information amateur scientists British Parliamentarians’ use of expertise and leadership effectiveness Netflix contest open-notebook science Culture, information overload and Cybercascades Cyberchiefs: Autonomy and Authority in Online Tribes (O’Neil) Darnton, Robert DARPA (Defense Advanced Research Projects Agency) Darwin, Charles amateur scientists’ contributions barnacle studies Hunch.com and insight and leap of thought long-form thinking science and publishing Data accuracy of published data crowdsourcing scientific and medical information data commons evaluating metadata information and overaccumulation of scientific data scientific knowledge Data.gov Data-information-knowledge-wisdom (DIKW) hierarchy Davis, John Debian Decision-making advantages of networked corporate and government networked decision-making Debian community Dickover’s social solutions facing reality Wikipedia policy Defaults Democracy echo chambers hiding knowledge and increasing group polarization reason, truth, and knowledge Denney, Reuel Deolalikar, Vinay Derrida, Jacques Descartes, René Dialogue, exploring diversity through Dickens, Charles Dickover, Noel Diderot, Denis The Difference (Page) Discourses Diversity appropriate scoping decreasing intelligence echo chambers forking moderating negative effects of of expertise race and gender respectful conversations over DNA Dr. Strangelove, Or How I Learned to Stop Worrying and Love the Bomb (film) Doctorow, Cory Dogger Bank Incident The Double Helix (Watson) Double-entry bookkeeping Dublin Core standard Dwarf planets eBird.org E-books Echo chambers Edge.org Ehrlich, Paul Einstein@Home Eliot, T.S. Embodied thought Emerson, Ralph Waldo Enders, John Engadget Environmental niche modeling Environmental Protection Agency (EPA) Eureqa computer program Evolutionary science Experiments, scientific method and Expert Labs Expertise Challenger investigation crowdsourcing diversity in networking knowledge networks outperforming individuals professionalization of scaling knowledge and networking sub-networks Extremism: group polarization Exxon Valdez oil disaster Facebook Fact-based knowledge as foundation of knowledge British backlash against British chimney sweep reform Darwin’s work on barnacles Hunch.com international dispute settlement See also Data Fact-finding missions Facts Linked Data standard Malthusian theory of population growth networked Failed science Fear, information overload and Federal Advisory Committees (FACs) Federal Highway Administration Feminism Filters information overload as filter failure knowledge management FoldIt Food, extending shelf life of Foodies Ford Motors Forking Forscher, Bernard K.
We-Think: Mass Innovation, Not Mass Production by Charles Leadbeater
1960s counterculture, Andrew Keen, barriers to entry, bioinformatics, c2.com, call centre, citizen journalism, clean water, cloud computing, complexity theory, congestion charging, death of newspapers, Debian, digital Maoism, disruptive innovation, double helix, Douglas Engelbart, Edward Lloyd's coffeehouse, frictionless, frictionless market, future of work, game design, Google Earth, Google X / Alphabet X, Hacker Ethic, Hernando de Soto, hive mind, Howard Rheingold, interchangeable parts, Isaac Newton, James Watt: steam engine, Jane Jacobs, Jaron Lanier, Jean Tirole, jimmy wales, Johannes Kepler, John Markoff, John von Neumann, Joi Ito, Kevin Kelly, knowledge economy, knowledge worker, lateral thinking, lone genius, M-Pesa, Mark Shuttleworth, Mark Zuckerberg, Marshall McLuhan, Menlo Park, microcredit, Mitch Kapor, new economy, Nicholas Carr, online collectivism, planetary scale, post scarcity, Richard Stallman, Shoshana Zuboff, Silicon Valley, slashdot, social web, software patent, Steven Levy, Stewart Brand, supply-chain management, The Death and Life of Great American Cities, the market place, The Wealth of Nations by Adam Smith, The Wisdom of Crowds, Thomas Kuhn: the structure of scientific revolutions, Whole Earth Catalog, Zipcar
A commonly owned irrigation system can be the shared platform for a mass of orange farmers. Commerce has often been built on shared foundations. This is especially so when the commons are not finite resources like woods and land, but knowledge and ideas.25 Bodies of ancient music are part of a cultural commons. Einstein’s theory of relativity is part of the commons, along with Watson and Crick’s description of the double helix of DNA. Language is a kind of commons. Dictionary publishers, broadcasters and teachers may attempt to claim authority over language but their right to do so is frequently contested. A language is not owned by anyone. The English language, which has developed by absorbing so many foreign influences, now provides a global common resource for business, science and culture.26 English has an estimated 380 million core speakers.
The puzzle of how the worm achieves this task was unravelled by a collaborative research effort, which in turn provided the basis for the global, public effort to map the human genome three decades later. Our map of the genome is the product of an elaborate shared authorship. Scientific collaborations like the one behind the unravelling of the C. elegans genome are a powerful working model for We-Think culture which the web is helping to spread. When Sydney Brenner set out to unravel the worm’s genome in 1965 – just eight years after Francis Crick and James Watson had uncovered the double-helix structure of DNA – little was known about how genes work. Brenner set out to find how the worm’s genes directed the organism’s growth, with only a small team of novice researchers and some crude tools: the scientists lifted worms into petri dishes with sharpened toothpicks. It was as if someone had seen the Wright brothers’ first flight and decided to start work on a jumbo jet.1 Brenner’s Laboratory of Molecular Biology provided the community’s core.
The same is true of We-Think. Diversity counts for little unless the different ideas that are floating around can be brought together to cross-pollinate. A community that is diverse but Balkanised will not be creative. People with different ideas must find a way to connect and communicate with one another. When they do, and in the right way, the results can be explosive. James Watson and Francis Crick unravelled the double-helix structure of DNA because they found a way to combine their very different outlooks. Crick’s training spanned physics, biology and chemistry. Watson had trained as a zoologist but had become fascinated by DNA after studying viruses. They combined their ideas through constant, intense conversation of a kind of which their rivals were incapable. Watson and Crick’s collaboration was a case of one plus one equals twelve.20 The larger the group and the more diverse perspectives are involved, the greater the benefits from combining them.
The Evolution of Everything: How New Ideas Emerge by Matt Ridley
"Robert Solow", affirmative action, Affordable Care Act / Obamacare, Albert Einstein, Alfred Russel Wallace, AltaVista, altcoin, anthropic principle, anti-communist, bank run, banking crisis, barriers to entry, bitcoin, blockchain, Boris Johnson, British Empire, Broken windows theory, Columbian Exchange, computer age, Corn Laws, cosmological constant, creative destruction, Credit Default Swap, crony capitalism, crowdsourcing, cryptocurrency, David Ricardo: comparative advantage, demographic transition, Deng Xiaoping, discovery of DNA, Donald Davies, double helix, Downton Abbey, Edward Glaeser, Edward Lorenz: Chaos theory, Edward Snowden, endogenous growth, epigenetics, Ethereum, ethereum blockchain, facts on the ground, falling living standards, Ferguson, Missouri, financial deregulation, financial innovation, Frederick Winslow Taylor, Geoffrey West, Santa Fe Institute, George Gilder, George Santayana, Gunnar Myrdal, Henri Poincaré, hydraulic fracturing, imperial preference, income per capita, indoor plumbing, interchangeable parts, Intergovernmental Panel on Climate Change (IPCC), invisible hand, Isaac Newton, Jane Jacobs, Jeff Bezos, joint-stock company, Joseph Schumpeter, Kenneth Arrow, Kevin Kelly, Khan Academy, knowledge economy, land reform, Lao Tzu, long peace, Lyft, M-Pesa, Mahatma Gandhi, Mark Zuckerberg, means of production, meta analysis, meta-analysis, mobile money, money: store of value / unit of account / medium of exchange, Mont Pelerin Society, moral hazard, Necker cube, obamacare, out of africa, packet switching, peer-to-peer, phenotype, Pierre-Simon Laplace, price mechanism, profit motive, RAND corporation, random walk, Ray Kurzweil, rent-seeking, reserve currency, Richard Feynman, rising living standards, road to serfdom, Ronald Coase, Ronald Reagan, Satoshi Nakamoto, Second Machine Age, sharing economy, smart contracts, South Sea Bubble, Steve Jobs, Steven Pinker, The Wealth of Nations by Adam Smith, Thorstein Veblen, transaction costs, twin studies, uber lyft, women in the workforce
But it is impossible to imagine relativity remaining undiscovered for long in the first half of the twentieth century, just as it is impossible to imagine the genetic code remaining undiscovered for long in the second half. The discovery of the double helix in 1953 remains plagued to this day by accusations that too much credit went to the first two people to solve the structure, and not to those who did some of the hard work that led to the insight. As Francis Crick pondered of his partner in the elucidation of the double helix, James Watson: ‘If Jim had been killed by a tennis ball, I am reasonably sure I would not have solved the structure alone, but who would?’ There were plenty of candidates: Maurice Wilkins, Rosalind Franklin, Raymond Gosling, Linus Pauling, Sven Furberg, and others. The double helix and the genetic code would not have remained hidden for long. Gregor Mendel, the father of genetics, is an interesting exception to the rule of simultaneous discovery.
The artificial synthesis in 1828 of urea, a substance produced hitherto exclusively by living creatures, was one such blow, which largely destroyed the idea that chemistry was going to find the vital principle. Vitalists fell back on physics, and later quantum physics, where they suggested that mysterious peculiarities might still exist. But that too was blown away by the discovery of the structure of DNA. In a way you could argue that the double helix did confirm that there is something peculiar and special about living tissue – namely, that it contains digital information capable of both replicating itself and instructing the synthesis of machinery for harnessing energy. The secret of life, unexpectedly, turned out to be an infinitely combinatorial message written in digital form in three-letter words in a four-letter alphabet. This was very much not what vitalists had expected; it seemed too mundane – though actually it is one of the most beautiful ideas ever to cross a human mind – that life is information.
Chapter 7: The Evolution of Technology On the history of the electric light, Friedel, R. 1986. Edison’s Electric Light. Rutgers University Press. On simultaneous invention, Wagner, A. 2014. Arrival of the Fittest. Current Books; Kelly, Kevin 2010. What Technology Wants. Penguin (Viking); and Armstrong, Sue 2014. The Gene that Cracked the Cancer Code. Bloomsbury Sigma p53. On the inevitability of the discovery of the double helix, Ridley, Matt 2006. Francis Crick. HarperCollins. On the four-factor formula, Spencer Weart cited in Kelly, Kevin 2010. What Technology Wants. Penguin (Viking). On Moore’s Law used to predict Pixar’s moment, Smith, Alvy Ray 2013. How Pixar used Moore’s Law to predict the future. Wired 17 April 2013. On Moore’s Law and its cousins, Ridley, Matt 2012. Why can’t things get better faster (or slower)?.
Complexity: A Guided Tour by Melanie Mitchell
Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Albert Einstein, Albert Michelson, Alfred Russel Wallace, anti-communist, Arthur Eddington, Benoit Mandelbrot, bioinformatics, cellular automata, Claude Shannon: information theory, clockwork universe, complexity theory, computer age, conceptual framework, Conway's Game of Life, dark matter, discrete time, double helix, Douglas Hofstadter, en.wikipedia.org, epigenetics, From Mathematics to the Technologies of Life and Death, Geoffrey West, Santa Fe Institute, Gödel, Escher, Bach, Henri Poincaré, invisible hand, Isaac Newton, John Conway, John von Neumann, Long Term Capital Management, mandelbrot fractal, market bubble, Menlo Park, Murray Gell-Mann, Network effects, Norbert Wiener, Norman Macrae, Paul Erdős, peer-to-peer, phenotype, Pierre-Simon Laplace, Ray Kurzweil, reversible computing, scientific worldview, stem cell, The Wealth of Nations by Adam Smith, Thomas Malthus, Turing machine
The first step is transcription (figure 6.2), which happens in the cell nucleus. From a single strand of the DNA, an enzyme (an active protein) called RNA polymerase unwinds a small part of the DNA from its double helix. This enzyme then uses one of the DNA strands to create a messenger RNA (or mRNA) molecule that is a letter-for-letter copy of the section of DNA. Actually, it is an anticopy: in every place where the gene has C, the mRNA has G, and in every place where the gene has A, the mRNA has U (its version of T). The original can be reconstructed from the anticopy. FIGURE 6.1. Illustration of the double helix structure of DNA. (From the National Human Genome Research Institute, Talking Glossary of Genetic Terms [http://www.genome.gov/glossary.cfm.]) FIGURE 6.2. Illustration of transcription of DNA into messenger RNA.
How exactly does an organism’s DNA cause the organism to have particular traits, such as tall or dwarf stems? How does DNA create a near-exact copy of itself during cell division (mitosis)? And how does the variation, on which natural selection works, come about at the DNA level? These questions were all answered, at least in part, within the next ten years. The biggest break came when, in 1953, James Watson and Francis Crick figured out that the structure of DNA is a double helix. In the early 1960s, the combined work of several scientists succeeded in breaking the genetic code—how the parts of DNA encode the amino acids that make up proteins. A gene—a concept that had been around since Mendel without any understanding of its molecular substrate—could now be defined as a substring of DNA that codes for a particular protein. Soon after this, it was worked out how the code was translated by the cell into proteins, how DNA makes copies of itself, and how variation arises via copying errors, externally caused mutations, and sexual recombination.
In humans, strings of DNA are actually double strands of paired A, C, G, and T molecules. Due to chemical affinities, A always pairs with T, and C always pairs with G. Sequences are usually written with one line of letters on the top, and the paired letters (base pairs) on the bottom, for example, TCCGATT … AGGCTAA … In a DNA molecule, these double strands weave around one another in a double helix (figure 6.1). Subsequences of DNA form genes. Roughly, each gene codes for a particular protein. It does that by coding for each of the amino acids that make up the protein. The way amino acids are coded is called the genetic code. The code is the same for almost every organism on Earth. Each amino acid corresponds to a triple of nucleotide bases. For example, the DNA triplet AAG corresponds to the amino acid phenylalanine, and the DNA triplet C A C corresponds to the amino acid valine.
A Short History of Nearly Everything by Bill Bryson
Albert Einstein, Albert Michelson, Alfred Russel Wallace, All science is either physics or stamp collecting, Arthur Eddington, Barry Marshall: ulcers, Brownian motion, California gold rush, Cepheid variable, clean water, Copley Medal, cosmological constant, dark matter, Dava Sobel, David Attenborough, double helix, Drosophila, Edmond Halley, Ernest Rutherford, Fellow of the Royal Society, Harvard Computers: women astronomers, Isaac Newton, James Watt: steam engine, John Harrison: Longitude, Kevin Kelly, Kuiper Belt, Louis Pasteur, luminiferous ether, Magellanic Cloud, Menlo Park, Murray Gell-Mann, out of africa, Richard Feynman, Stephen Hawking, supervolcano, Thomas Malthus, Wilhelm Olbers
., p. 211. 13 “worth two Nobel Prizes . . .” Maddox, Rosalind Franklin, p. 327. 14 “not to give Avery a Nobel Prize.” White, Rivals, p. 251. 15 “a member of a highly popular radio program called The Quiz Kids . . .” Judson, The Eighth Day of Creation, p. 46. 16 “without my learning any chemistry . . .” Watson, The Double Helix, p. 28. 17 “the results of which were obtained ‘fortuitously' . . .” Jardine, Ingenious Pursuits, p. 356. 18 “In a severely unflattering portrait . . .” Watson, The Double Helix, p. 26. 19 “in the summer of 1952 she posted a mock notice . . .” White, Rivals, p. 257; and Maddox, p. 185. 20 “apparently without her knowledge or consent.” PBS website, “A Science Odyssey,” undated. 21 “Years later Watson conceded. . .” Quoted in Maddox, p. 317. 22 “a 900-word article by Watson and Crick titled ‘A Structure for Deoxyribose Nucleic Acid.' ” De Duve, vol. 2, p. 290. 23 “It received a small mention in the News Chronicle . . .”
Neither was formally trained in biochemistry. Their assumption was that if you could determine the shape of a DNA molecule you would be able to see—correctly, as it turned out—how it did what it did. They hoped to achieve this, it would appear, by doing as little work as possible beyond thinking, and no more of that than was absolutely necessary. As Watson cheerfully (if a touch disingenuously) remarked in his autobiographical book The Double Helix, “It was my hope that the gene might be solved without my learning any chemistry.” They weren't actually assigned to work on DNA, and at one point were ordered to stop it. Watson was ostensibly mastering the art of crystallography; Crick was supposed to be completing a thesis on the X-ray diffraction of large molecules. Although Crick and Watson enjoy nearly all the credit in popular accounts for solving the mystery of DNA, their breakthrough was crucially dependent on experimental work done by their competitors, the results of which were obtained “fortuitously,” in the tactful words of the historian Lisa Jardine.
Far ahead of them, at least at the beginning, were two academics at King's College in London, Wilkins and Franklin. The New Zealand–born Wilkins was a retiring figure, almost to the point of invisibility. A 1998 PBS documentary on the discovery of the structure of DNA—a feat for which he shared the 1962 Nobel Prize with Crick and Watson—managed to overlook him entirely. The most enigmatic character of all was Franklin. In a severely unflattering portrait, Watson in The Double Helix depicted Franklin as a woman who was unreasonable, secretive, chronically uncooperative, and—this seemed especially to irritate him—almost willfully unsexy. He allowed that she “was not unattractive and might have been quite stunning had she taken even a mild interest in clothes,” but in this she disappointed all expectations. She didn't even use lipstick, he noted in wonder, while her dress sense “showed all the imagination of English blue-stocking adolescents.”*44 However, she did have the best images in existence of the possible structure of DNA, achieved by means of X-ray crystallography, the technique perfected by Linus Pauling.
The Information: A History, a Theory, a Flood by James Gleick
Ada Lovelace, Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Albert Einstein, AltaVista, bank run, bioinformatics, Brownian motion, butterfly effect, citation needed, Claude Shannon: information theory, clockwork universe, computer age, conceptual framework, crowdsourcing, death of newspapers, discovery of DNA, Donald Knuth, double helix, Douglas Hofstadter, en.wikipedia.org, Eratosthenes, Fellow of the Royal Society, Gödel, Escher, Bach, Henri Poincaré, Honoré de Balzac, index card, informal economy, information retrieval, invention of the printing press, invention of writing, Isaac Newton, Jacquard loom, Jaron Lanier, jimmy wales, Johannes Kepler, John von Neumann, Joseph-Marie Jacquard, lifelogging, Louis Daguerre, Marshall McLuhan, Menlo Park, microbiome, Milgram experiment, Network effects, New Journalism, Norbert Wiener, Norman Macrae, On the Economy of Machinery and Manufactures, PageRank, pattern recognition, phenotype, Pierre-Simon Laplace, pre–internet, Ralph Waldo Emerson, RAND corporation, reversible computing, Richard Feynman, Rubik’s Cube, Simon Singh, Socratic dialogue, Stephen Hawking, Steven Pinker, stochastic process, talking drums, the High Line, The Wisdom of Crowds, transcontinental railway, Turing machine, Turing test, women in the workforce
Lecture Notes in Physics, no. 642. Berlin: Springer, 2003. Waldrop, M. Mitchell. “Reluctant Father of the Digital Age.” Technology Review (July–August 2001): 64–71. Wang, Hao. “Some Facts About Kurt Gödel.” Journal of Symbolic Logic 46 (1981): 653–59. Watson, David L. “Biological Organization.” Quarterly Review of Biology 6, no. 2 (1931): 143–66. Watson, James D. The Double Helix. New York: Atheneum, 1968. ———. Genes, Girls, and Gamow: After the Double Helix. New York: Knopf, 2002. ———. Molecular Models of Life. Oxford: Oxford University Press, 2003. Watson, James D., and Francis Crick. “A Structure for Deoxyribose Nucleic Acid.” Nature 171 (1953): 737. ———. “Genetical Implications of the Structure of Deoxyribonucleic Acid.” Nature 171 (1953): 964–66. Watts, Duncan J. “Networks, Dynamics, and the Small-World Phenomenon.”
They could not see these molecules; they could only seek clues in the shadows cast by X-ray diffraction. But they knew a great deal about the subunits. Each nucleotide contained a “base,” and there were just four different bases, designated as A, C, G, and T. They came in strictly predictable proportions. They must be the letters of the code. The rest was trial and error, fired by imagination. What they discovered became an icon: the double helix, heralded on magazine covers, emulated in sculpture. DNA is formed of two long sequences of bases, like ciphers coded in a four-letter alphabet, each sequence complementary to the other, coiled together. Unzipped, each strand may serve as a template for replication. (Was it Schrödinger’s “aperiodic crystal”? In terms of physical structure, X-ray diffraction showed DNA to be entirely regular.
Who writes them? Who reads them? The Tie Club recognized that the problem was not just information storage but information transfer. DNA serves two different functions. First, it preserves information. It does this by copying itself, from generation to generation, spanning eons—a Library of Alexandria that keeps its data safe by copying itself billions of times. Notwithstanding the beautiful double helix, this information store is essentially one-dimensional: a string of elements arrayed in a line. In human DNA, the nucleotide units number more than a billion, and this detailed gigabit message must be conserved perfectly, or almost perfectly. Second, however, DNA also sends that information outward for use in the making of the organism. The data stored in a one-dimensional strand has to flower forth in three dimensions.
Junk DNA: A Journey Through the Dark Matter of the Genome by Nessa Carey
Location, location, location We are still left with a difficult conceptual problem. If the DNA sequence at the centromere isn’t very conserved, and the critical factor is the placement of the CENP-A protein, how does the cell ‘know’ where the centromere should be on each chromosome? Why is it always near the middle of chromosome 1, but near the end of chromosome 14? To understand this, we have to develop a more sophisticated image of the DNA in our cells. The DNA double helix is an iconic image, probably the defining image in biology. But it doesn’t really represent what DNA is like. DNA is a very long spindly molecule. If you stretched out the DNA from one human cell it would reach for two metres, assuming you joined up the material from all the chromosomes. But this DNA has to fit into the nucleus of a cell, and the nucleus has a diameter of just one hundredth of a millimetre.
It remains a little beacon of expression in the chromosomal darkness of the inactive X.10 Left to right, right to left So we have here a situation where a piece of ‘junk’ DNA – one that doesn’t code for protein – is absolutely essential for the function of half the human race. Scientists have recently discovered that this process of X inactivation requires at least one other piece of junk DNA. Confusingly, this is encoded in exactly the same place on the X chromosome as Xist. DNA, as we know, is composed of two strands (the iconic double helix). The machinery that copies DNA to form RNA always ‘reads’ DNA in one direction, which we could call the beginning and end of a specific sequence. But the two strands of DNA run in opposite directions to each other, a little like one of those funicular railways we find at older seaside and mountain resorts. This means that a particular region of DNA may carry two lots of information in one physical location, running in opposite directions to each other.
Instead, patterns are often maintained or created as a consequence of the histone modification combinations that are already present on the genome.10,11 This also seems to hold for the opposite effect, where active regions remain active. Long non-coding RNAs have been reported to be expressed from regions where protein-coding genes are switched on. These long non-coding RNAs stay moored to the genome region where they are produced, possibly by forming a third strand to accompany the double helix of DNA. These long non-coding RNAs bind to the enzymes that place methyl modifications on DNA and stop them doing their job. This keeps the genes in that region in an active state.12 If you’re inactive, you stay inactive Xist, which is critical for switching off expression from one of the X chromosomes in a female cell, was one of the first functional long non-coding RNAs to be identified.
The End of Illness by David B. Agus
Danny Hillis, discovery of penicillin, double helix, epigenetics, germ theory of disease, Google Earth, impulse control, information retrieval, longitudinal study, meta analysis, meta-analysis, microbiome, Murray Gell-Mann, pattern recognition, Pepto Bismol, personalized medicine, randomized controlled trial, risk tolerance, Steve Jobs, the scientific method
Chromosomes are composed of strands of DNA, which in turn are made up of tens of thousands of genes. DNA’s well-known double-helix structure is connected by rungs of approximately 3 billion base pairs, represented by four chemical bases, or nucleotides, known most commonly by the letters A (adenine), G (guanine), C (cytosine), and T (thymine). These nucleotides are key structural elements for the genes that individually or in combination determine everything from a person’s hair color to their predisposition for Parkinson’s disease. After thirteen years of work, the project was declared complete two years ahead of schedule in 2003, coinciding with the fiftieth anniversary of Francis Crick and James Watson’s Nobel Prize–winning discovery of the DNA double helix. Certain sequences of these building blocks make up genes, just like certain sequences of letters create words.
By the beginning of the twentieth century, we still didn’t have a clue as to exactly what was responsible for all these developing laws of inheritance. Mendel’s work wasn’t published until 1866 and went unnoticed and unappreciated until the turn of the century. It would take nearly another century from Mendel’s publication for science to dig deeper, when James Watson and Francis Crick proposed the double helix, or spiral staircase, structure of the DNA molecule in 1953. In essence, Watson and Crick officially discovered DNA, changing the textbooks forever now that we had an image of what “the secret to life” actually looked like. Such a feat has an almost religious significance in biology. Suddenly, we had a seemingly tangible thing to help explain what makes us tick and how we are made at the molecular level.
., 222 Cincinnati Children’s Hospital Medical Center: personalized medicine at, 118, 119 circadian rhythm, 240–43, 246, 247 circulatory system, 16, 213 Cisco Systems, 283, 284 Cleveland Clinic antioxidant studies at, 165–66 family history link to cancer study by, 68 Coffey, Don, 82 Cold Spring Harbor Laboratory: complex medicine systems research at, 114 colds, 17, 130, 208–12 collaboration: and sharing of medical information, 280–83 College Alumni Health Study, 221 colon cancer, 36, 72, 75–76, 79, 88, 112, 175, 296 colonoscopies, 60, 112, 296 color of food/fruits and vegetables, 184, 194 of skin, 139–41, 142 colorectal cancer, 62, 130, 136, 137 Columbia University autism studies at, 83–84 obesity-sleep study at, 244–45 complex systems medicine, 114–17 comprehensive metabolic panel (CMP), 58 computers, 114–15, 119, 272–74, 280 Consumer Reports magazine: diet survey of, 180 Cooper, Kenneth, 224–25 Cooper Aerobics Center, 224 correlation: in research studies, 135, 136 cortisol, 213, 238, 241, 245, 255 Crestor, 45, 75 See also statins Crick, Francis, 69, 103 Crohn’s disease, 72, 79 CT screenings, 296 cystic fibrosis, 104–5 cytochrome P450 (CYP450), 119–20 cytokines, 211 cytosine, 69 Darwin, Charles, 102, 103, 114 death causes of, 24, 233, 296 end of illness and, 2–3 search for master switch and, 294–301 statistics about, 23–27 deep-vein thrombosis (DVT), 72, 80 degenerative diseases, 232 dehydroascorbic acid, 154, 155, 157 Dell, Michael: Well at Dell program of, 282–83, 284 dementia, 161, 204, 205, 207–8, 227 demographics: as factor in research studies, 50–51 depression, 118–20, 121, 193, 202–3, 227, 240, 245, 253 diabetes and body as homeostatic, 138–39 as cause of death, 24, 233 cholesterol and, 201 environment and, 79 in the future, 260 genetics and, 72, 79 growth hormone and, 48, 242 hemoglobin A1C test and, 59–60 inflammation and, 47, 196 Personal Inventory Questionnaire and, 16 physical activity and, 221, 231 prenatal development and, 83 selenium and, 172 as systemic disease, 43 technology and, 264 vitamin C and, 163 vitamin D and, 133 weight and, 49 diagnosis, medical as dictating treatment, 29, 117 and genetics of infectious thinking, 31–41 keeping regular schedules and, 236–37 Personal Inventory Questionnaire and previous, 18 personalized treatment and, 117 proteomics and, 111–12 scientific thinking and, 29 statistics about death and, 23 technology and, 264–65, 267–69 diet/eating, 174–94 cancer and, 188, 214 and definition of health, 21 doing nothing and, 293 end of illness and, 296 genomics and, 121–22 gut feelings and, 192, 193 in history, 150–52 and keeping a regular schedule, 237, 238–39, 243–45, 246, 249, 258 microbiome and, 137, 187–90 multivitamins and, 158–59, 181 personalized treatment and, 121–22, 187 physical activity, 227 principles of health and, 3 protein in, 106 proteomics and, 121–22 and questions that patients need to ask doctors, 11 sleep and, 240, 243–45, 251 statistics about death and, 23 tests concerned with, 58 vitamin D and, 142, 143, 144, 145, 184–85 vitamins/supplements and, 157–58, 174–78, 194 digestion brain and, 191–93 microbiome and, 187–90 Personal Inventory Questionnaire and, 17 technology and, 268 DNA, decoding of, 118–19 DNA (deoxyribonucleic acid) as blame for illness, 22–23 decoding of, 103–4 differences in, 70–71 double-helix structure of, 69, 103 drug responses and, 118 early experiments on, 104 encoding of, 106 free radicals and, 161 in the future, 267–68 as great theoretical triumph of biology, 100–101 inflammation and, 200–202 information gained from analysis of, 111 as list of parts, 99 as marker for risk of disease, 70 mitochondrial, 229 personalized treatment and, 118 protein and, 99–100 repair of, 201, 229, 266 restaurant analogy and, 99, 100, 104, 105 search for master switch and, 295 sequencing of, 104, 106, 108 as static, 111 technology and, 263–64 understanding of, 100–105 variations in, 71 See also genes/genetics; genetic testing “do no harm” oath, 4–5 doctors and amount of time spent with patients, 55 annual examainations by, 53, 270 and being your own doctor first, 53–55, 66 discussions between patients and, 10–11, 55–56, 57, 61–62, 63–64 “do no harm” oath of, 4–5 friend/family member on visit with, 57 game plan for visit with, 56–57, 64 information given to, 55 “informed choice”/“shared decision making” and, 54 mistakes of, 297 paternalistic style of, 54 patient’s relationship with, 53–55, 66, 287 recording of discussions with, 57 sharing of medical information and, 285 as staying current, 54 and tests for doctors to run, 57–60 dogs, 257–58, 295 doing nothing, 288–93 dopamine, 256 down-regulation, 146–47 downtime, 254–57, 258 drugs advancements in, 23 complex systems medicine and, 116 definition of, 148–49 development of, 93 discussions with doctors about, 11, 63–64 doing nothing and, 293 end of illness and, 295 environment and, 84–86, 95 in the future, 260, 261 genetics and, 72, 73, 116 individual differences in response to, 118, 122 in laboratory animals, 93–94 list of, 56 and multiple outcomes of single drug, 85–86 need for innovation concerning, 297–98 negative reactions to, 91 “off-label” use of, 88 Personal Inventory Questionnaire and, 18 personalized treatment and, 117–22, 189–90, 260 platinum-based, 90, 93 regulation of, 292 and shades of gray, 91–94 side effects of, 47, 167 for sleep, 249–51 technology and, 189–90, 260, 261 trade-offs concerning, 48 vitamins/supplements as, 148–49 See also pharmaceutical industry; specific drug Dubner, Stephen, 135 Duke University: Avastin studies at, 89 Ecuador: human growth hormone study in, 48–49 Egg Concept, 82–83 Einhorn, Lawrence, 90 The Elements of Style (Strunk and White), 123–24 emotions gut feelings and, 193 and keeping a regular schedule, 238 See also feelings The Emperor of All Maladies (Mukherjee), 35 employer-based medical information programs, 282–84, 283n, 286, 287 endocrine disease, 72 endocrine signals, 191–92 endorphins, 213 energy, 15, 117, 159, 192, 229, 237 engineering application to football of, 273 complex systems medicine and, 114–15 computer, 280 protein studies and, 108–9, 117 enterotypes, 188–90 environment and body as homeostatic, 138–39 body (micro), 82–95 circadian rhythm and, 240–42 definition of, 81 drugs and, 84–86, 95 Egg Concept and, 82–83 family health tree and, 68 genetics and, 71, 79–81, 82, 95 importance of, 83 and keeping a regular schedule, 239, 244 laboratory studies and, 86–91, 93–94 life expectancy and, 95 outside (macro), 94–95 prenatal development and, 83 principles of health and, 3 protein and, 97–100 shades of gray and, 91–94 for sleep, 248–49 Epidemiology and Public Health Department (University College, London): heart, 231 epigenetics, 205–6 epilepsy, 210 esophageal cancer, 62 estrogen, 16, 84 ethnicity: as factor in research studies, 50 European Molecular Biology Laboratory (Heidelberg, Germany): microbiome, 188 European Prospective Investigation into Cancer and Nutrition (EPIC), 30 examinations, medical: annual, 53 exercise.
The Great Influenza: The Story of the Deadliest Pandemic in History by John M. Barry
Albert Einstein, Brownian motion, centralized clearinghouse, conceptual framework, coronavirus, discovery of penicillin, double helix, Fellow of the Royal Society, germ theory of disease, index card, Louis Pasteur, Marshall McLuhan, Mason jar, means of production, statistical model, the medium is the message, the scientific method, traveling salesman, women in the workforce
“likened to a gene”: Oswald Avery, Colin McLeod, and Maclyn McCarty, “Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types,” Journal of Experimental Medicine (Feb. 1, 1944, reprinted Feb. 1979), 297–326. “little influence on thought”: Gunther Stent, Introduction, The Double Helix: A Norton Critical Edition by James Watson (1980), xiv. “obviously of fundamental importance”: Nobelstiftelsen, Nobel, the Man, and his Prizes (1962), 281. “Avery showed”: James Watson, The Double Helix: A Norton Critical Edition, See 12, 13, 18. “Avery gave us”: Horace Judson, Eighth Day of Creation: The Makers of the Revolution in Biology (1979), 94. “we were very attentive”: Ibid., 59. “nonsense to say that we were not aware”: Ibid., 62–63. “dark ages of DNA”: Watson, Double Helix, 219. “opening…the field of molecular biology”: Dubos, Professor, Institute and DNA, 156. “keeping his own counsel”: Ibid., 164. CHAPTER THIRTY-SIX solid evidence: Transcript of Influenza Commission minutes, first session, Oct. 30, 1918; second session, Nov. 22, 1918; fourth session, Feb. 14, 1919, Winslow papers.
A prize would endorse his findings and the committee would take no such risk, not until others confirmed them. The official history of the organization that gives the prize states, “Those results were obviously of fundamental importance, but the Nobel Committee found it desirable to wait until more became known….” Others were determined to make more known. James Watson, with Francis Crick the codiscoverer of the structure of DNA, wrote in his classic The Double Helix that “there was general acceptance that genes were special types of protein molecules” until “Avery showed that hereditary traits could be transmitted from one bacterial cell to another by purified DNA molecules…. A very’s experiments strongly suggested that future experiments would show that all genes were composed of DNA…. A very’s experiment made [DNA] smell like the essential genetic material….
Simon Flexner Memorial Pamphlet. New York: Rockefeller Institute for Medical Research, 1946. Smith, Elbert. When the Cheering Stopped: The Last Years of Woodrow Wilson. New York: Morrow, 1964. Starr, Paul. The Social Transformation of American Medicine. New York: Basic Books, 1982. Steele, Richard W. Free Speech in the Good War. New York: St. Martin’s Press, 1999. Stent, Gunther. Introduction to The Double Helix: A Norton Critical Edition, by James Watson, edited by Gunther Stent. New York: Norton, 1980. Sternberg, Martha. George Sternberg: A Biography. Chicago: American Medical Association, 1925. Thompson, E. Symes. Influenza. London: Percival & Co., 1890. Thomson, David, and Robert Thomson. Annals of the Pickett-Thomson Research Laboratory, vols. 9 and 10, Influenza. Baltimore: Williams and Wilkens, 1934.
The Nature of Technology by W. Brian Arthur
Andrew Wiles, business process, cognitive dissonance, computer age, creative destruction, double helix, endogenous growth, Geoffrey West, Santa Fe Institute, haute cuisine, James Watt: steam engine, joint-stock company, Joseph Schumpeter, Kenneth Arrow, Kevin Kelly, knowledge economy, locking in a profit, Mars Rover, means of production, Myron Scholes, railway mania, Silicon Valley, Simon Singh, sorting algorithm, speech recognition, technological singularity, The Wealth of Nations by Adam Smith, Thomas Kuhn: the structure of scientific revolutions
Every step involved had been done already” But Mullis’s “easy” solution was to “amplify DNA by the repeated reciprocal extension of two primers hybridized to the separate strands of a particular DNA sequence.” In lay terms this means finding short stretches of DNA (primers) that flag the beginning and end of the DNA stretch to be copied, and separating the DNA double helix into two separate strands. Once the primers are added, the two strands can build from these (using an enzyme called polymerase) and pick up complementary components to form two new double helixes. Repeating this process again and again multiplies the new double helix copies from 2 to 4 to 8 to 16… indefinitely. This was something easy at that time only to a practitioner with considerable experience of functionalities in working with DNA—something easy to Mullis. The Pyramid of Causality I have described invention in this chapter as a micro-process by which an individual (or several) comes up with a novel way of doing things.
Protocol: how control exists after decentralization by Alexander R. Galloway
Ada Lovelace, airport security, Berlin Wall, bioinformatics, Bretton Woods, computer age, Craig Reynolds: boids flock, discovery of DNA, Donald Davies, double helix, Douglas Engelbart, Douglas Engelbart, easy for humans, difficult for computers, Fall of the Berlin Wall, Grace Hopper, Hacker Ethic, informal economy, John Conway, John Markoff, Kevin Kelly, Kickstarter, late capitalism, linear programming, Marshall McLuhan, means of production, Menlo Park, moral panic, mutually assured destruction, Norbert Wiener, old-boy network, packet switching, Panopticon Jeremy Bentham, phenotype, post-industrial society, profit motive, QWERTY keyboard, RAND corporation, Ray Kurzweil, RFC: Request For Comment, Richard Stallman, semantic web, SETI@home, stem cell, Steve Crocker, Steven Levy, Stewart Brand, Ted Nelson, telerobotics, the market place, theory of mind, urban planning, Vannevar Bush, Whole Earth Review, working poor
So, in 1953, when Watson and Crick discovered DNA (perhaps not anticipating its subsequent ascendance to the supreme deﬁnition of life itself ﬁfty years later), they prove not simply that life is an informatic object (that much had been clear for decades with the Bertillon system of criminal phrenology, the quantiﬁcation of human movement by Muybridge, and so on) but rather that life is an aesthetic object; it is a double helix, an elegant, hyper-Platonic form that rises like a ladder into the heights of aesthetic purity. Life was no longer a “pair of ragged claws / Scuttling across the ﬂoors of silent seas” (Eliot), it was a code borne from pure mathematics, an object of aesthetic beauty, a double helix! This historical moment—when life is deﬁned no longer as essence, but as code—is the moment when life becomes a medium.97 95. Sanford Kwinter, “Introduction: War in Peace,” in Branden Hookway, Pandemonium: The Rise of Predatory Locales in the Postwar Period (Princeton: Princeton Architectural Press, 1999), pp. 9–10, emphasis mine. 96.
See Society, disciplinary Discipline and Punish (Foucault), 21, 31 Discourse, in Marx, 91 Discourse Networks, 1800/1900 (Kittler), 18, 22 Dispositif, 25 Distributed Denial of Service (DDoS), 214 Distribution and control, 47 as diagram, 197 and management, 110, 243 network (see Network, distributed) Dividual (Deleuze), 86 DNA, 26, 111 computer, 112 Documenta X, 187 Doll Yoko. See da Rimini, Francesca Domain Name System (DNS), 5, 8–10, 12, 47, 49–50, 141, 143, 218 Dominguez, Ricardo, 175, 214 Double helix, 111 Dreyfus, Hubert, 17, 102 Dr-K, 171 Drucker, Peter, 17 Druckrey, Timothy, 19, 211–212 Drummond, Bill, 227n32 DVD, 126, 172 Dyer-Witheford, Nick, 33 Ebay, 233–238 Edison, Thomas, 126 Eisenstein, Sergei, 89–90, 102 Electronic Disturbance Theater (EDT), 175, 214, 217, 234 Empire, 158 Empire (Hardt and Negri), 24–26, 209n1 Engelbart, Douglas, 106n84 Entropy, 103–105 Enzensberger, Hans Magnus, 16, 18, 56–58, 209 Ethernet, 127 Etoy, 9–10, 219–232, 234 eToys, 229, 232 Eugenics, 85n13 Expanded Cinema (Youngblood), 210n7 Experiments in Art and Technology (EAT), 210n7 Exploits, 167–168, 186.
The Healing of America: A Global Quest for Better, Cheaper, and Fairer Health Care by T. R. Reid
Berlin Wall, British Empire, double helix, employer provided health coverage, fudge factor, Kenneth Arrow, medical malpractice, profit maximization, profit motive, single-payer health, South China Sea, the payments system
Public health officials frequently point to two key discoveries, both announced in 1953, that crystallize the difference:• In February, at the Cavendish Laboratory of Cambridge University, the American biologist James Watson and the British physicist Francis Crick figured out the double-helix structure of deoxyribonucleic acid, DNA. That discovery demonstrated how DNA carries and passes on each human being’s hereditary information. “We have found the secret of life,” Crick said. This wildly celebrated biological advance led to the Nobel Prize, a No.1 best seller (Watson’s memoir, The Double Helix), and the science of genomics, which may someday cure chronic diseases and spawn a new world of individualized drugs designed to save people who have a genetic disposition for a lethal illness. • In November, a German-born American doctor named Ernst L.
contact lenses Co-operative Commonwealth Federation (CCF), Canadian Cooperative Medical System, Chinese coronary bypass coronary heart disease cosmetic surgery Costa Rica Couchepin, Pascal Crawford, Amylyn Crick, Francis crimes, violent CT scans Cuba, Cuban health care as based on Beveridge Model Culbert, Heather Cyprus Czech Republic dal bhat Davies, Marcus Debs, Eugene V. Declaration of Independence Democratic Progressive Party,Taiwanese Denmark dental care depression dhami Dhanwanthari (Hindu god of healing) diabetes diet Disability-Adjusted Life Expectancy (DALE) disability-adjusted life year (DALY) DNA doctors, see providers, health care Dominica doshas Double Helix,The (Watson) Douglas,Thomas Clement drinking drugs and prescriptions in Out-of-Pocket system price of education Egypt Eisenhower, Dwight D. EKG elections, U.S. electroacupuncture elektronischen Gesundheitskarte (German smart card) Emergency Hospital Service Emergency Medical Treatment and Active Labor Act (EMTALA; 1986) emergency room emphysema Epstein, Richard Escuela Latinoamericana de Ciencias Médicas European Union Evans, Robert exercise eyeglasses false teeth Family Endowment Society fast food Ferlic, Donald Finland Fleming, Alexander Fleming, Kevin C.
The New Sell and Sell Short: How to Take Profits, Cut Losses, and Benefit From Price Declines by Alexander Elder
Covered Writing Question 108—The Demands of Naked Writing Question 109—Brokers Against Traders Question 110—Forex Market Question 111—Learning to Become a Better Trader Question 112—Trading Signals of the Force Index Question 113—False Breakouts and Divergences Question 114—Shorting and Covering Signals Question 115—Shorting Tactics GRADING YOUR ANSWERS PART FOUR - LESSONS OF THE BEAR MARKET CHAPTER 9 - BEARS MAKE MONEY THE BEAR WAS BEGINNING TO STIR IN ITS CAVE THE SENTIMENT INDICATORS ARE EARLY THE TOP OF THE BULL MARKET BEARISH DIVERGENCES AT THE 2007 TOP THE BUBBLE POPS: MGM SHORTING A HIGH-FLYER A BEAR MARKET IS A DESTROYER OF VALUE SWINGING IN AND OUT OF A MAJOR DOWNTREND TRADING IN A DOWNCHANNEL PREPARED FOR A SURPRISE “BULL MARKETS HAVE NO RESISTANCE AND BEAR MARKETS HAVE NO SUPPORT” FOR WHOM THE BELL TOLLS OR THE HOUND BARKS TWICE MR. BUFFETT BUYS TOO SOON MAY I POUR SOME GASOLINE ON YOUR FIRE? KEEP SHORTING ON THE WAY DOWN CHAPTER 10 - GROPING FOR A BOTTOM THIS STOCK MARKET IS NOT GOING DOWN TO ZERO A “DOUBLE HELIX” GIVES A BUY SIGNAL JUST IN TIME FOR THE PARTY MY FAVORITE MAJOR BOTTOM SIGNAL SELLING A BULL EVERY BULL STUMBLES A SCREAMING SHORT CONCLUSION REFERENCES Acknowledgments ABOUT THE AUTHOR WILEY TRADING SERIES Founded in 1807, John Wiley & Sons is the oldest independent publishing company in the United States. With offices in North America, Europe, Australia and Asia, Wiley is globally committed to developing and marketing print and electronic products and services for our customers’ professional and personal knowledge and understanding.
And what about the weekly NH-NL? This index declined to minus 5,854—a zone that had been reached before at bear market bottoms. This reading alone does not tell us whether this is the absolute bear market bottom or just an intermediate low prior to a bear market rally. Of course, the massive bullish divergence between the bottoms 1, 2, and 3 indicated that the first option was more likely. A “DOUBLE HELIX” GIVES A BUY SIGNAL The message of this chart was unmistakable (Figure 10.2). It told traders not to panic. It signaled to cover shorts and get busy drawing our shopping lists. Whenever you look at a market using different timeframes, technical trading signals seldom emerge at the same time. Professionals have rules for dealing with this challenge, while beginners do not even recognize it and obsessional traders keep waiting for perfection until the train leaves the station.
That’s where we make strategic decisions, before turning to the dailies for shorter-term tactical timing. The daily chart of NH-NL finally caught the weekly’s tune in April, when the number of New Highs (the green line) rose above that of New Lows (the red line). Because the daily NH-NL is very sensitive, I tend to wait until its second bullish crossover before accepting it as a confirmed buy signal. Stephen Morris, a Spiker in Idaho, jokingly called this “Double helix” or “double Alex.” JUST IN TIME FOR THE PARTY These three charts of Deckers Outdoors (DECK) (Figures 10.3-Figures 10.5), along with several intraday charts omitted for the reasons of space, came recently from Steve Alcorn, a member of SpikeTrade, who wrote: “I’ve attached my diary from my very first trade, which was on March 10, 2009, the first day of the big upmove. I went long DECK, which headed upward for six weeks.
In Pursuit of Memory: The Fight Against Alzheimer's by Joseph Jebelli
Albert Einstein, Alfred Russel Wallace, Berlin Wall, double helix, epigenetics, global pandemic, Isaac Newton, Kickstarter, lateral thinking, longitudinal study, Louis Pasteur, Mahatma Gandhi, megacity, meta analysis, meta-analysis, microbiome, mouse model, phenotype, placebo effect, Ronald Reagan, Rosa Parks, Skype, stem cell, Thomas Kuhn: the structure of scientific revolutions
Fragments of nerve cells lay strewn in its wake, while other cells appeared to have been pierced by shards of the dark threads themselves. Scanning the wreckage further, the microscopists soon landed on the odd tangles of material that appeared to choke the cells from the inside. And almost immediately it was clear these were a different kind of adversary. They twisted and coiled around themselves in a strikingly ordered manner, forming curious helices much like the DNA double helix discovered by James Watson and Francis Crick only one decade earlier. ‘If you want to understand function,’ Crick famously said, ‘study structure.’ In that vein Kidd and Terry began contemplating the atomic architecture of the plaques and tangles, comparing it with what was already known about how organic molecules behave. Unknowingly, they had just formed a crucial allegiance with the blossoming field of biochemistry.
At that time, however, genes were thought to be entities that only gave rise to basic aspects of human biology such as height, build and eye colour. They certainly weren’t believed to have much (if anything) to do with the intricate vagaries of the mind. In any case, genes were still inaccessible molecules and so physicians were more interested in the chemical basis of disease. But by the 1980s the DNA double helix had come and gone and gene sequencing technology was well on its way. George Glenner, a molecular pathologist at the US National Institute on Aging, seized upon Heston’s results. Quiet and reserved, formal and aloof, with wavy silver hair and an unassuming gaze, Glenner didn’t know much about the brain when he began working on Alzheimer’s in 1983. He was considered an outsider by many neuroscientists.
., ‘Alzheimer’s families clamor for drug’, Wall Street Journal, 11 February 2012 Warren, H. S., Tompkins, R. G., Moldawer, L. L., Seok, J., Xu, W., Mindrinos, M. N.,… Davis, R. W., ‘Mice are not men’, Proceedings of the National Academy of Sciences of the United States of America, 112 (4), 2015, E345 Watkins, C. C., and Treisman, G. J., ‘Cognitive impairment in patients with AIDS–prevalence and severity’, HIV AIDS, 7, 2015, 35–47 Watson, J., The Double Helix, Weidenfeld & Nicolson, 2011 Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., Kirschner, M. W., ‘A protein factor essential for microtubule assembly’, Proceedings of the National Academy of Sciences, 72 (5), 1975, 1858–62 Weissman, I. L., ‘The road ended up at stem cells’, Immunological Reviews, 185, 2002, 159–74 White, L., Petrovitch, H., Ross, G. W., Masaki, K. H., Abbott, R. D., Teng, E.
River Out of Eden: A Darwinian View of Life by Richard Dawkins
Boosted telephone systems, recopied tapes, photocopies of photocopies-analog signals are so vulnerable to cumulative degradation that copying cannot be sustained beyond a limited number of generations. Genes, on the other hand, can selfcopy for ten million generations and scarcely degrade at all. Darwinism works only because-apart from discrete mutations, which natural selection either weeds out or preservesthe copying process is perfect. Only a digital genetic system is capable of sustaining Darwinism over eons of geological time. Nineteen fifty-three, the year of the double helix, will come to be seen not only as the end of mystical and obscurantist views of life; Darwinians will see it as the year their subject went finally digital. The river of pure digital information. majestically flowing through geological time and splitting into three billion branches, is a powerful image. But where does it leave the familiar features of life? Where does it leave bodies, hands and feet, eyes and brains and whiskers, leaves and trunks and roots?
Ridley, Matt, The Red Queen: Sex and the Evolution of Human Nature (New York: Macmillan, 1994). Sagan, Carl, Cosmos (New York: Random House, 1980). and Ann Druyan, Shadows of Forgotten Ancestors (New York: Random House, 1992). Tinbergen, Nike, The Herring Gull's World (New York: Harper & Row, 1960). , Curious Naturalists (London: Penguin, 1974). Trivers, Robert, Social Evolution (Menlo Park, Calif.: BenjaminCummings, 1985). Watson, James D., The Double Helix: A Personal Account of the Discovery of the Structure of DNA (New York: Athenewn, 1968). Weiner, Jonathan, The Beak of the Finch: A Story of Evolution in Our Time (New York: Knopf, 1994). Wickler. Wolfgang, Mimicry in Plants and Animals, R. D. Martin, trans. (New York: McGraw-Hill, 1968). Williams, George C., Natural Selection: Domains, Levels, and Challenges (New York: Oxford University Press, 1992).
The Ones We've Been Waiting For: How a New Generation of Leaders Will Transform America by Charlotte Alter
"side hustle", 4chan, affirmative action, Affordable Care Act / Obamacare, basic income, Berlin Wall, Bernie Sanders, carbon footprint, clean water, collective bargaining, Columbine, corporate personhood, correlation does not imply causation, Credit Default Swap, crowdsourcing, David Brooks, Donald Trump, double helix, East Village, ending welfare as we know it, Fall of the Berlin Wall, feminist movement, Ferguson, Missouri, financial deregulation, Francis Fukuyama: the end of history, gig economy, glass ceiling, Google Hangouts, housing crisis, illegal immigration, immigration reform, income inequality, Intergovernmental Panel on Climate Change (IPCC), job-hopping, Kevin Kelly, knowledge economy, Lyft, mandatory minimum, Marc Andreessen, Mark Zuckerberg, mass incarceration, McMansion, medical bankruptcy, move fast and break things, move fast and break things, Nate Silver, obamacare, Occupy movement, passive income, pre–internet, race to the bottom, RAND corporation, Ronald Reagan, sexual politics, Silicon Valley, single-payer health, Snapchat, TaskRabbit, too big to fail, Uber and Lyft, uber lyft, universal basic income, unpaid internship, We are the 99%, white picket fence, working poor, Works Progress Administration
KENNEDY, CAPETOWN, SOUTH AFRICA, JUNE 6, 1966 CONTENTS TITLE PAGE COPYRIGHT DEDICATION EPIGRAPH INTRODUCTION AUTHOR’S NOTE THE ONES PART ONE CHAPTER 1 One Sunny Tuesday CHAPTER 2 Harry Potter and the Spawn of the Boomers CHAPTER 3 Getting Into College, Getting Out of Debt CHAPTER 4 The Last Dinosaurs CHAPTER 5 This Is the War That Never Ends PART TWO CHAPTER 6 The Rocket Ship CHAPTER 7 The Crash CHAPTER 8 Fix the System CHAPTER 9 Fuck the System CHAPTER 10 The Locals CHAPTER 11 The Young Grand Old Party PART THREE CHAPTER 12 House of Glass, 2016 CHAPTER 13 The Pilgrimage of Alexandria Ocasio-Cortez CHAPTER 14 “Senator, We Run Ads” CHAPTER 15 Millennial Red CHAPTER 16 The Pink Wave CHAPTER 17 Defend, Distance, Defect, or Defeat CHAPTER 18 Ladies of the House CHAPTER 19 The Double Helix EPILOGUE ACKNOWLEDGMENTS NOTE ON SOURCES NOTES INDEX ABOUT THE AUTHOR INTRODUCTION Love ’em or hate ’em, this much is true: one day soon, millennials will rule America. This is neither wish nor warning but a fact, rooted in the physics of time and the biology of human cells. Millennials—born between 1981 and 1996—are already the largest living generation, the majority of the workforce, and will soon eclipse their parents as the biggest bloc of eligible voters.
For more than a decade, Republicans ran ads against Democrats in swing districts linking them to Pelosi, who was portrayed as the Wicked Witch of the Democratic Party. By fall of 2019, Republicans had recast their villain. Within a month of his swearing in, Max Rose drew a Republican challenger who launched her campaign with an attack on “self-described socialist Alexandria Ocasio-Cortez.” It was clear that the Republicans wouldn’t be running against their actual Democratic opponents—they’d be running against AOC. CHAPTER 19 The Double Helix In early 2017, Pete and Chasten Buttigieg adopted a brown-and-white rescue beagle. Pete named him Truman, because Harry Truman had once said, “If you want a friend in Washington, get a dog.” “But you live in South Bend,” I reminded him, shortly after Truman came to live in their stately white house with columns and a portico. Pete replied with a vague smile. Throughout 2017 and 2018, Pete had been watching and waiting.
They wouldn’t like to admit it, but their goals were largely aligned: universal health care, a massive government investment in addressing climate change, a twenty-first-century social safety net, and a reformed democracy. The skirmishes between the Obama pragmatists and the Bernie activists—the ones who wanted to fix the system and the ones who wanted to fight it—would be about the scope and implementation of those goals. The two unlikely young stars were like twin strands of DNA, a double helix that contained the blueprint for the Democratic Party’s future. And that future, regardless of the outcome in 2020, has already arrived. EPILOGUE It was a Wednesday morning in November and a heartless sun was shining. It greeted kids in the morning as they sat down to breakfast and learned who had won the 2016 presidential election. It shone through the windows of elementary schools where students asked their teachers if they would be deported, or if Trump would start a nuclear war, or if he would bring slavery back.
Richard Dawkins: How a Scientist Changed the Way We Think by Alan Grafen; Mark Ridley
Alfred Russel Wallace, Arthur Eddington, bioinformatics, cognitive bias, computer age, conceptual framework, Dava Sobel, double helix, Douglas Hofstadter, epigenetics, Fellow of the Royal Society, Haight Ashbury, interchangeable parts, Isaac Newton, Johann Wolfgang von Goethe, John von Neumann, loose coupling, Murray Gell-Mann, Necker cube, phenotype, profit maximization, Ronald Reagan, Stephen Hawking, Steven Pinker, the scientific method, theory of mind, Thomas Kuhn: the structure of scientific revolutions, Yogi Berra, zero-sum game
(I cannot resist suggesting the usit—pronounced ‘use it’—as an applicable little term to represent the disputed unit-of-selection whatever that may be and mean.) The continued debate between gene-selectionists and group-selectionists identifies an ambiguity in the meaning of the word ‘gene’, even when this is defined as a rarely-recombining stretch of DNA. A gene could refer to the group of atoms that is organized into a particular DNA sequence—each time the double helix replicates, the gene is replaced by two new genes—or it could refer to the abstract sequence that remains the same gene no matter how many times the sequence is replicated. We might call these concepts the material gene and the informational gene. Dawkins refers to something like the informational gene when he describes the selfish gene as ‘all replicas of a particular bit of DNA’ but I believe that he neither wanted nor intended this definition.
Memes also have a physical form in their transmission from one individual to another, sometimes as sound vibrations, or text on paper, or electronic signals relayed through a modem. When these ‘outward’ forms of a meme are perceived, they elicit changes in a nervous system that constitute the meme’s ‘cryptic’ form. The material basis of the cryptic form is probably unique to each nervous system colonized by the meme. Memetic replication, then, has nothing like the elegant simplicity of the double helix. If the material form of memes is problematic, might it be more appropriate to define memes purely in terms of information? But what are the memes in our evolving concepts of the gene? These concepts have been reformulated and recombined with other ideas at each step in the chain of transmission. How can one identify the ‘nuggets’ of ideas that remain unchanged during this process and thus persist ‘for enough generations to serve as a unit of natural selection’?
Non-fiction publishers had been given plenty of warning that science was a rich vein to mine, evolutionary theory in particular. In 1961 the screen writer Robert Ardrey’s African Genesis popularized the killer ape theory. Konrad Lorenz followed with On Aggression in 1963 and Desmond Morris with The Naked Ape in 1967. The latter would sell more than ten million copies. The great success of Jim Watson’s The Double Helix (1968), Jacques Monod’s Chance and Necessity (1970) and Jacob Bronowski’s The Ascent of Man (z973) reinforced the view that science could generate a huge best-seller almost every year. In this context, The Selfish Gene was merely the 1976 incarnation of a regular phenomenon. But it stood out in two ways. One was the sheer brilliance of the prose. Dawkins’ sentences had such rhythm, his words had such precision and his thoughts had such order that his book was tasty literature as well as nourishing argument.
The End of College: Creating the Future of Learning and the University of Everywhere by Kevin Carey
Albert Einstein, barriers to entry, Bayesian statistics, Berlin Wall, business cycle, business intelligence, carbon-based life, Claude Shannon: information theory, complexity theory, David Heinemeier Hansson, declining real wages, deliberate practice, discrete time, disruptive innovation, double helix, Douglas Engelbart, Douglas Engelbart, Downton Abbey, Drosophila, Firefox, Frank Gehry, Google X / Alphabet X, informal economy, invention of the printing press, inventory management, John Markoff, Khan Academy, Kickstarter, low skilled workers, Lyft, Marc Andreessen, Mark Zuckerberg, meta analysis, meta-analysis, natural language processing, Network effects, open borders, pattern recognition, Peter Thiel, pez dispenser, ride hailing / ride sharing, Ronald Reagan, Ruby on Rails, Sand Hill Road, self-driving car, Silicon Valley, Silicon Valley startup, social web, South of Market, San Francisco, speech recognition, Steve Jobs, technoutopianism, transcontinental railway, uber lyft, Vannevar Bush
Because of this class, she later told me, she plans to major in chemical and biological engineering. I settled into a seat in the back row, flipped up the desk, and pulled out my study materials. After two months of watching Lander lecture, my class notebook was almost full. We had begun with the building blocks of biochemistry before proceeding on a long voyage of intellectual discovery, through Mendelian genetics, Crick and Watson’s double helix, and the modern age of biotechnology. Lander used a storyteller’s flair for drama as he worked through complex explanations of biochemistry, genetic mutation, and RNA transcription. When his tales reached a point of crucial discovery (often involving a Nobel Prize awarded to one of his MIT colleagues), you could see sparks of enthusiasm in his eyes—even from the last row. After each lecture, my fellow students and I would retreat to our laptops to tackle MIT’s famously challenging “problem sets,” exercises meant to test and solidify the knowledge we had gained in class.
Edit the dopamine molecule so it can no longer make strong hydrogen bonds. I got it wrong the first couple of times, went back to my notes, watched a portion of the lecture again, and finally nailed down the underlying principles of molecular bonding in my mind. Later in the course, we learned how the amino acids in DNA molecules fit together, and how Linus Pauling raced with Crick and Watson to discover the double helix, along with the intricate dance of transcription and translation, mismatch detection and repair. The p-sets in this part of the course used another computer program, called the “Integrative Genome Viewer,” which allowed me to see what happens when mutations alter single base pairs in a DNA sequence that can run hundreds of millions of pairs long, resulting in a new set of instructions for protein creation and sometimes disastrous consequences for the organism in question.
., 95 Craigslist, 132, 145 Credentials, academic, 6, 22, 46, 61, 182, 191–95, 200, 248 accreditation and, 117–18 admissions process and, 212 digital, 6, 186, 191–93, 199, 204, 218–19, 231, 234, 240 (see also Badges) labor market and, 185–86, 195, 197, 201, 246 personal recommendations and, 217 time-based, 48, 194, 209, 216 See also specific degrees Credit hours, 48, 194, 209, 237 Crick, Francis, 3, 70 Dark Ages, 17 Dartmouth College, 23, 79, 101, 147, 204 Davidson College, 243 Defense Department, U.S., 125, 148 Democratic Party, 42 Demosthenes, 25 Deoxyribonucleic acid (DNA), 2, 37, 70, 221 Dev Bootcamp, 139–41 Dickens, Charles, 17 Digital Equipment Corporation, 168 DiMaggio, Paul, 50, 117 Disney-Pixar, 208 DK Eyewitness Travel Guide: USA, 164 DNA, 2, 37, 70, 221 Doctorates, see PhDs Doerr, John, 153 Double helix, 3 Downes, Stephen, 150 Downton Abbey (television series), 217 Drucker, Peter, 107 Duke University, 140, 161 Dunster, Henry, 22, 197–99 Eaton, Nathaniel, 198 eBay, 145 Edison, Thomas, 96 Education, U.S. Department of, 9, 36, 56, 99, 157, 252 edX, 11, 143, 163, 170–72, 176–78, 214, 223, 231 certificates of course completion through, 203, 219, 233 controversy at Harvard over, 180 cost of course development for, 228 expansion of consortium of, 204, 244 forums moderated by teaching assistants on, 88 Lander’s lectures and course materials posted on, see Introduction to Biology—The Secret of Life (7.00x) process of signing up for classes on, 13 Eight-Year Study, The, 90 Einstein, Albert, 45 Elective system, 30–31, 47, 49, 54, 146, 197, 226 laissez-faire approach of, 76, 241 Eliot, Charles William, 29–32, 47, 49, 54, 65, 76, 138, 185, 239 Elite private institutions, 53–55, 134–36, 229, 241, 253 admissions process of, 161, 195, 212–13, 215, 245 high schools, 90, 195 international, 143 online sharing of resources by, 170 status competition among, 165 See also specific universities Emergence of the American University, The (Veysey), 34 Engelbart, Douglas, 122–26, 156 Engels, Friedrich, 45 Enlightenment, 26 Equifax, 200 Ericsson, K.
How to Create a Mind: The Secret of Human Thought Revealed by Ray Kurzweil
Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Albert Einstein, Albert Michelson, anesthesia awareness, anthropic principle, brain emulation, cellular automata, Claude Shannon: information theory, cloud computing, computer age, Dean Kamen, discovery of DNA, double helix, en.wikipedia.org, epigenetics, George Gilder, Google Earth, Isaac Newton, iterative process, Jacquard loom, John von Neumann, Law of Accelerating Returns, linear programming, Loebner Prize, mandelbrot fractal, Norbert Wiener, optical character recognition, pattern recognition, Peter Thiel, Ralph Waldo Emerson, random walk, Ray Kurzweil, reversible computing, selective serotonin reuptake inhibitor (SSRI), self-driving car, speech recognition, Steven Pinker, strong AI, the scientific method, theory of mind, Turing complete, Turing machine, Turing test, Wall-E, Watson beat the top human players on Jeopardy!, X Prize
The communists considered it to be fascist propaganda, and his sudden, unexpected death has been attributed to the secret police of the Soviet Union.4 In 1953, nearly a century after the publication of Darwin’s seminal book, American biologist James D. Watson (born in 1928) and English biologist Francis Crick (1916–2004) provided the first accurate characterization of the structure of DNA, describing it as a double helix of two long twisting molecules.5 It is worth pointing out that their finding was based on what is now known as “photo 51,” taken by their colleague Rosalind Franklin using X-ray crystallography, which was the first representation that showed the double helix. Given the insights derived from Franklin’s image, there have been suggestions that she should have shared in Watson and Crick’s Nobel Prize.6 Rosalind Franklin took the critical picture of DNA (using X-ray crystallography) that enabled Watson and Crick to accurately describe the structure of DNA for the first time.
Dahm, “Discovering DNA: Friedrich Miescher and the Early Years of Nucleic Acid Research,” Human Genetics 122, no. 6 (2008): 565–81, doi:10.1007/s00439-007-0433-0; PMID 17901982. 4. Valery N. Soyfer, “The Consequences of Political Dictatorship for Russian Science,” Nature Reviews Genetics 2, no. 9 (2001): 723–29, doi:10.1038/35088598; PMID 11533721. 5. J. D. Watson and F. H. C. Crick, “A Structure for Deoxyribose Nucleic Acid,” Nature 171 (1953): 737–38, http://www.nature.com/nature/dna50/watsoncrick.pdf and “Double Helix: 50 Years of DNA,” Nature archive, http://www.nature.com/nature/dna50/archive.xhtml. 6. Franklin died in 1958 and the Nobel Prize for the discovery of DNA was awarded in 1962. There is controversy as to whether or not she would have shared in that prize had she been alive in 1962. 7. Albert Einstein, “On the Electrodynamics of Moving Bodies” (1905). This paper established the special theory of relativity.
The Clockwork Universe: Saac Newto, Royal Society, and the Birth of the Modern WorldI by Edward Dolnick
Albert Einstein, Apple's 1984 Super Bowl advert, Arthur Eddington, clockwork universe, complexity theory, double helix, Edmond Halley, Isaac Newton, Johannes Kepler, lone genius, music of the spheres, Pierre-Simon Laplace, Richard Feynman, Saturday Night Live, scientific worldview, Simon Singh, Stephen Hawking, Thomas Kuhn: the structure of scientific revolutions
He happily devoted long hours to constructing models of his solar system from colored paper and drawing plans for a version made of silver and adorned with diamonds and pearls. “No one,” he boasted, “ever produced a first work more deserving of admiration, more auspicious and, as far as its subject is concerned, more worthy.” In the decades to come Kepler would make colossal discoveries, but his pride in his elaborate geometric model never faded. Centuries later the biologist James Watson would proclaim his double helix model of DNA “too pretty not to be true.” Kepler had felt the same joy and the same certainty, but eventually the data left him no choice but to acknowledge that he had gone wrong, again. His perfect theory was only a fantasy, but it proved enormously fruitful even so. For one thing, Mystery of the Universe transformed Kepler’s career. He sent a copy of the book to Tycho Brahe, the leading astronomer of the day, who found it impressive.
But to Newton and Leibniz, the answer to Caroline’s question was simple. It made all the difference in the world. Chapter Forty-Four Battle’s End From its earliest days, science has been a dueling ground. Disputes are guaranteed, because good ideas are “in the air,” not dreamed up out of nowhere. Nearly every breakthrough—the telescope, calculus, the theory of evolution, the telephone, the double helix—has multiple parents, all with serious claims. But ownership is all, and scientists turn purple with rage at the thought that someone has won praise for stolen insights. The greats battle as fiercely as the mediocre. Galileo wrote furiously of rivals who claimed that they, not he, had been first to see sunspots. They had, he fumed, “attempted to rob me of that glory which was mine.” Even the peaceable Darwin admitted, in a letter to a colleague urging him to write up his work on evolution before he was scooped, that “I certainly should be vexed if anyone were to publish my doctrines before me.”
(Each angle of a hexagon is 120 degrees, for instance, so three or more hexagons cannot meet at one vertex.) 153 If you needed dice: Marcus du Sautoy, Symmetry (New York: Harper, 2008), p. 5. 154 He burst into tears: Caspar, Kepler, p. 63. 154 “Now I no longer regretted”: Koestler, The Sleepwalkers, p. 251. 155 “For a long time I wanted”: Owen Gingerich, “Johannes Kepler and the New Astronomy,” available at http://adsabs.harvard.edu/full/1972QJRAS..13..346G. 155 He happily devoted: Koestler, The Sleepwalkers, p. 269. 155 “No one,” he boasted: Caspar, Kepler, p. 71. 155 “too pretty not to be true”: James Watson, The Double Helix (New York: Touchstone, 2001), p. 204. 156 “Never in history”: Gingerich, “Johannes Kepler and the New Astronomy,” p. 350. CHAPTER 26. WALRUS WITH A GOLDEN NOSE 157 “Would that God deliver me”: Rossi, The Birth of Modern Science, p. 70. 158 “the heavenly motions are nothing but”: Koestler, The Sleepwalkers, p. 392. 158fn Not by the human ear: Rattansi, “Newton and the Wisdom of the Ancients,” p. 189. 158fn The first person to refer: Curtis Wilson, “Kepler’s Laws, So-Called,” HAD News (newsletter of the Historical Astronomy Division of the American Astronomical Society), no. 31, May 1994. 158 “My brain gets tired”: Giorgio de Santillana, The Crime of Galileo, p. 106fn. 159 In his student days: Ferguson, Tycho and Kepler, pp. 31–32. 160 had cost a ton of gold: Gingerich, “Johannes Kepler and the New Astronomy,” p. 350. 160 “any single instrument cost more”: Koestler, The Sleepwalkers, p. 278. 160 “I was in possession”: Ibid., p. 345.
Falter: Has the Human Game Begun to Play Itself Out? by Bill McKibben
23andMe, Affordable Care Act / Obamacare, Airbnb, American Legislative Exchange Council, Anne Wojcicki, artificial general intelligence, Bernie Sanders, Bill Joy: nanobots, Burning Man, call centre, carbon footprint, Charles Lindbergh, clean water, Colonization of Mars, computer vision, David Attenborough, Donald Trump, double helix, Edward Snowden, Elon Musk, ending welfare as we know it, energy transition, Flynn Effect, Google Earth, Hyperloop, impulse control, income inequality, Intergovernmental Panel on Climate Change (IPCC), Jane Jacobs, Jaron Lanier, Jeff Bezos, job automation, life extension, light touch regulation, Mark Zuckerberg, mass immigration, megacity, Menlo Park, moral hazard, Naomi Klein, Nelson Mandela, obamacare, off grid, oil shale / tar sands, pattern recognition, Peter Thiel, plutocrats, Plutocrats, profit motive, Ralph Waldo Emerson, Ray Kurzweil, Robert Mercer, Ronald Reagan, Sam Altman, self-driving car, Silicon Valley, Silicon Valley startup, smart meter, Snapchat, stem cell, Stephen Hawking, Steve Jobs, Steve Wozniak, Steven Pinker, strong AI, supervolcano, technoutopianism, The Wealth of Nations by Adam Smith, traffic fines, Travis Kalanick, urban sprawl, Watson beat the top human players on Jeopardy!, Y Combinator, Y2K, yield curve
In our world smart means a 130 and stupid means an 85 IQ—we don’t have a word for an IQ of 12,952.”12 You can see how what I’ve been calling “the human game” might be somewhat altered by such a development, or any development remotely like it. It’s leverage on a different scale. But before we figure out how likely all this is, and before we figure out if it’s a good idea, let’s look at one particular real-world example of these fast-growing new powers. It will give us a better sense of how far we can go and still stay ourselves. 14 In 1953, Francis Crick and James Watson discovered the double-helix nature of DNA, which was a remarkable achievement, but it didn’t change the world overnight. Some highlights on the genetic time line since: 1974: The first genetically modified animal is produced (a mouse). 1996: Some Scottish blokes clone a sheep and name it Dolly. 1999: An artist named Eduardo Kac sticks some jellyfish DNA in a rabbit and makes her glow a phosphorescent green when exposed to black light.
The first category, as I’ve said, is called somatic genetic engineering; this second approach usually travels under the name of “germline” genetic engineering, because the germ line consists of those cells that pass on their traits in the course of reproduction. You could also call it heritable genetic modification. “Now, for the first time ever,” says Doudna, we possess the power to “direct the evolution of our own species. This is unprecedented in the history of life on earth. It is beyond our comprehension.”12 Ever since Watson and Crick discovered the double helix, ethicists have debated the possibility of designing babies, but it’s always been a somewhat remote and academic debate, because no one thought it could actually be done anytime soon. Then, CRISPR. In April 2015, researchers at Sun Yat-Sen University, in Taiwan, announced that they had used the technique to edit the genomes of nonviable human embryos, modifying the gene that produces thalassemia, a blood disorder.
And so, those who want to allow germline engineering often argue by analogy: If it’s okay to try to get your kids into Princeton, then surely it’s also okay to turn certain genes off or on in order to try to make those kids more intelligent. If we don’t limit the ability of parents to push and harass and love their children in a particular direction, why would we limit their ability to accomplish the same thing more efficiently with genetic engineering? It would make Ayn Rand mad as hell to suggest that parents shouldn’t be able to do this if they want. Here’s James Watson, discoverer of the double helix, who describes himself as a libertarian: “I don’t believe we can let the government start dictating the decisions people make about what sort of families they’ll have.”3 But, in fact, both mate selection and parental pressure come with strong limits built in. You can spend a great deal of time looking for the spouse you think will provide your child with the best possible genes, but in the end all you can do is create a set of possibilities, just change the odds some.
Science...For Her! by Megan Amram
Albert Einstein, blood diamonds, butterfly effect, crowdsourcing, dark matter, Dmitri Mendeleev, double helix, Google Glasses, Isaac Newton, Kickstarter, Mark Zuckerberg, pez dispenser, Schrödinger's Cat, Steve Jobs, Ted Kaczynski, the scientific method, Wall-E, wikimedia commons
Genes use DNA (short for deoxyribonucleic acid, what a mouthful! And we all know what to do with mouthfuls, right, ladies? That’s right—SWALLOW!!) to transmit traits. For example, my mom is, like, totally amazing and, through DNA, I totally inherited all the best parts of her. FIG. 1.14 When a cell starts to replicate, the DNA strand (which is made of two strands curled around each other in a shape called a double helix) unzips. And if that DNA strand gains weight over the winter, maybe it will never be able to rezip again! That always happens to me over the holidays! I mean, there’s cookies, eggnog, Communion wafers—how am I not going to gain weight? Body of Christ? More like Body of Carb-st! (NOTE: I am a Jew, but I often attend Catholic Mass services to closet-eat, since none of my liberal Jew gal pals will ever catch me.
., x Chelsea, xvii chemistry, 31–61, 63, 190 of cooking, 32–35 childbirth, 23 children, 10–11 Chloe, viii Chris, xiii Christina, ix Christine, xv Christmas trees, 97–99 chromosomes, 18 Chunky Love, ix Claire, xii Claire-Marie, ix Clara, ix Class, 24 Claudia, xi climate change, 103 coal, 102 coma, 23 computers, 151 confabulating, 101 Cookies, ix cooking, 32–35 Cori, Carl Ferdinand, 174 Cori, Gerty, 174 Courtney, xiv covalent bonds, 55 cover letter, girlfriend, 134–35 cover-ups, 79, 89 Craigslist, 154 Cris, ix Cristy, ix crocus, 100 Crystal, ix Crystal Glass, ix Curie, Irene, 170 Curie, Marie, 60, 170, 173, 174 Curie, Pierre, 174 Cynthia, xv D daisy, 100 Dana, xvii Dani, xix Daniella, xviii Danielle, xiv dark matter, 72 Darwin, Charles, 26 dating, 154–59 online sites for, 154–56 Davida, viii Dawn, xv Day-Lewis, Daniel, 15 death, 20–23, 50, 51 Debbie, xv Deen, Paula, 33–35, 89 dendrology, 91–99 Denise, xviii depression, 128 Dereka, xii Deschanel, Zooey, 80 Devil Wears Prada, The (Weisberger), 119 diagnosis, 126 diamonds, 45, 102 Diana, xvii Diaz, Cameron, 15 disease, 123–26 displacement, 65 DNA, 17–18, 138 Donica, xix Donna, xvi double helix, 17 Drew, xiii driving, women and, 65–68 drugs, 90, 131–32 E Earth, 147, 150 age of, 147 earth sciences, 87–114 Eat, Pray, Love (Gilbert), 119 E. coli, 130 economics, 159–61 Edna, xvi eggs, 2–3, 18 freezing of, 157 egg whites, 34 Einstein, Albert, 75 electronic music, 162 electrons, 55 elements, 46–49, 57 Eliana, viii Elizabeth, xi Ella, ix Ellen, viii Ellie, xiii e-mail, 151 Emily, xi Emma, xi employment, 174–75 Erica, xiv Erin, xiv Eryn, xviii Esther, viii ethanol, 39 eukaryotes, 14 Eve, 28 Evelyn, x evolution, 26–28 vs. religion, 27–28 expiration dates, 130 extinction, 26 extraterrestrial life, 150 Ezri, xv F face mash, 19 Faith, xi fallopian tubes, 136 Family, 24 fats, 33 female orgasms, 107 fertilization, 3 Fifty Shades Freed (James), 119 Fifty Shades of Grey (James), 119 final exam, 190–91 floriculture, 100–101 flowers, study of, 100–101 Fluffy, xix Food and Drug Administration (FDA), 131 food poisoning, 130 formaldehyde, 45 4-vinylguaiacol, 44 Francesca, xi Franklin, Rosalind, 138 fruit salad, 34 G G., ix Gabriella, x Galileo Galilei, 75 gamma radiation emissions, 57 garden burgers, 34 gas, 56 gay-ball warming, 103 genes, 17 Genesis 4:1, 119 genetics, 16–19 Genus, 24 Getgo, ix Giana, xi Gina, xviii “gin and Drano,” 37 girlfriend cover letter, 134–35 Girls’ Guide to Fishing and Hunting, The (Bank), 119 global warming, 103–6 contributing to, 105 fashion staples for, 106 glycogen, conversion of, 174 Golda, xix Gone Girl (Flynn), 119 Goodall, Jane, 170, 173 Goodnight Moon (Brown), 111 Grace, x Gregoria, xviii gravity, 147 H H.P.T., xix Hailey, x hairspray, 105 Hamm, xi Hannah, x Harissa, xix Harper, x Heather, xiii Heidi, viii Hemings, Sally, 72 He’s Just Not That into You (Behrendt), 119 Holly, xvii homosexuality, 77 hoodies, 79 Hooke, Robert, 12 Hoover, J.
The World According to Physics by Jim Al-Khalili
accounting loophole / creative accounting, Albert Einstein, butterfly effect, clockwork universe, cognitive dissonance, cosmic microwave background, cosmological constant, dark matter, double helix, Ernest Rutherford, Fellow of the Royal Society, germ theory of disease, gravity well, Internet of things, Isaac Newton, Murray Gell-Mann, publish or perish, Richard Feynman, Schrödinger's Cat, Stephen Hawking, supercomputer in your pocket, the scientific method
In writing this, I can imagine my colleagues in chemistry and biology rolling their eyes with exasperation at this typical physicist’s sense of self-importance. On the other hand, it is true that many of the early advances in molecular biology and genetics in the twentieth century were made by physicists, such as Leo Szilard, Max Delbrück, and Francis Crick. Crick, in particular, who discovered (with James Watson and Rosalind Franklin) the double helix structure of DNA, was hugely influenced by yet another physicist, Erwin Schrödinger, whose remarkable 1944 book, What is Life?, is still relevant today. On the applied side, physicists have been key to the development of many of the techniques that are used to probe living matter, from X-ray diffraction to MRI scanners. Even the humble microscope, without which no biology lab could function, was invented by physicists, thanks to hundreds of years of research into the nature of light and the way lenses refract and focus it, culminating in the work of Antonie van Leeuwenhoek and Robert Hooke, who both used the microscope in the seventeenth century to study living organisms.
INDEX absolute zero, 102 Adams, Douglas, 5 AdS/CFT (anti–de Sitter/conformal theory correspondence; gauge/ gravity duality), 232–33 alpha particles, 101–2 Anderson, Carl, 103–4 Anderson, Philip, 47 Andromeda galaxy, 98 antigravity, 212–13 antimatter, 7, 13, 103–5 antiquarks, 96n1, 176n2 Anu (Sumerian god), 1 Archimedes, 16, 25 Aristotle, 16, 45, 57–58, 74, 77 artificial intelligence (AI), 161, 235, 240, 250, 255, 256–57 atomic clocks, 39 atomism, 16–17, 45 atoms, 15; composition of, 224; types of, 16–17 axions, 200 Banks, Joseph, 108 Bell, John, 126–27 beta radioactivity, 94, 96 Big Bang, 7, 32, 34, 98–101, 103, 150; cosmology model of, 179; in eternal inflation theory, 216; verification of, 269–70 binary data, 251 binary pulsars, 226 biology, 21, 111, 161, 236, 242–44 biomass, 151 biophysics, 242 bits, 251 black holes, 195, 221, 223, 233; entropy of, 279; evaporation of, 215, 220; formation of, 106; gravitational pull from, 72; Hawking radiation emitted from, 24, 220 block universe model, 68–69, 70–71, 79–81 Bohm, David, 136 Bohr, Niels, 122–23, 124, 125, 132 Boltzmann, Ludwig, 46 Born’s rule, 124 Bose-Einstein condensates, 226 bosons, 6–7, 13, 25, 93, 96–97, 181 Broglie, Louis de, 136 bubble universes, 217–18 Bullet Cluster, 197 butterfly effect, 157–58, 160 carbon, 106 celestial mechanics, 55 CERN (European Organization for Nuclear Research), 174, 228 chaos, 21, 160–61 chemistry, 21, 91, 236, 241–42, 256; quantum theory and, 9, 117, 173, 246 Classical Physics, 111–12 climate, 151, 240, 271, 272–73 cloud technology, 255 COBE satellite, 199 cognitive dissonance, 272 cold dark matter, 179, 200 colour charge, 95–96, 175–76 comets, 18 complexity, 21 complex systems, 161 computer science, 241, 246, 250–58 concordance model, 179 condensed matter, 232, 233, 236 confirmation bias, 272, 277 conformal cyclic cosmology, 215–16 conservation, laws of, 41 consistent histories interpretation, 127 conspiracy theories, 271–72 constrained minimal supersymmetry, 231 Copenhagen interpretation, xiii, 123, 125, 127, 128 Copernican (heliocentric) model, 4, 26–27, 126 Copernicus, Nicolaus, 27 Cosmic Background Explorer (Explorer 66), 199n2 cosmic inflation, 208–19, 276 cosmic microwave background (CMB), 34, 101, 197, 198–99 cosmological constant, 203 cosmology, 12 creation myths, 1 Crick, Francis, 243 CT (computed tomography), 246 curved spacetime, 64n2, 78, 82, 187, 234; dark matter and, 196; gravitational field linked to 72–73, 163, 170; inflation and, 209 dark energy, 7, 9, 193, 202–5, 210, 226, 276 dark matter, 7, 9, 42, 105–6, 179, 193–201, 231, 276 de Broglie–Bohm theory, 137 decoherence, 133, 135 Delbrück, Max, 243 Democritus, 16, 44–45 Descartes, René, 55, 57–58, 59–60, 74, 77 determinism, 155–58 diffraction, 114 Dirac, Paul, 13, 14, 103, 171–72 Dirac notation, 124 disorder, 21 DNA, 243, 249 Doppler effect, 63 double helix, 243 doubt, in scientific inquiry, 266–67, 274 dwarf galaxies, 197 dynamical collapse interpretation, 127 economics, 161 Einstein, Albert, xiv, 124, 222–23, 280; field equations of, 82, 129; light quanta hypothesized by, 112–13; Newtonian theory replaced by, 8, 36, 61; nonlocality and entanglement mistrusted by, 131–32; as philosophical realist, 130; photoelectric effect explained by, 29–30; thought experiments by, 56.
Structures: Or Why Things Don't Fall Down by J. E. Gordon
The lilies of the field toil not, neither do they calculate, but they are probably excellent structures, and indeed Nature is generally a better engineer than man. For one thing she has more patience and, for another, her way of going about the design process is quite different. In living creatures the broad general arrangement or lay-out of the parts is controlled during growth by the R N A-DNA mechanism – the famous ‘double helix’ of Wilkins, Crick and Watson.* However, in each individual plant or animal, once the general arrangement has been achieved, there is a good deal of latitude about the structural details. Not only the thickness, but also the composition of each load-carrying component is determined, to a considerable extent, by the use which is actually made of it and by the forces which it has to resist during life.† Thus the proportions of a living structure tend to become optimized with regard to its strength.
Nature is generally rather good at avoiding stress concentrations of this and other kinds. However, one would think that stress concentrations must be of significance in orthopaedic surgery, especially when the surgeon fits a stiff metal prosthesis to a relatively flexible bone. NOTE. In Inglis’s formula (p. 67) L is the length of a crack proceeding inwards from the surface, i.e. half the length of an internal crack. * * * *See, for instance, The Double Helix, by James D. Watson, Weidenfeld & Nicolson, 1968. †The process also works in reverse; the bones of astronauts lose calcium and become weaker after a period of weightlessness in space. * Almost the only woman to have gained distinction in elasticity, Mademoiselle Sophie Germain (1776-1831), was French. It may be relevant that two of our most highly educated and theoretically-minded engineers during this period, Sir Marc Brunei (1769-1849) and his son, Isambard Kingdom Brunei (1806-59), were of French origin.
If the interior of the charge is still cold, it is likely to crack when the circumferential strain in the case reaches about 1-0 per cent. If this happens, then the flames will penetrate down the crack and destroy the case. This naturally results in a sensational explosion as another Polaris bites the dust. Round about 1950, it occurred to some of us that it would be advantageous to make the rocket case, not from a metal tube, but in the form of a cylindrical vessel, wound from a double helix of strong glass fibres, bonded together with a resin adhesive. If the fibre angles are calculated correctly, it is possible so to arrange things that the change of diameter of the tube under pressure is small. It is true that, in such a situation, the tube will elongate more than it otherwise would, like Mile Vionnet’s waists, but, for various reasons, a longitudinal extension is less damaging to the propellant.
Life in the Universe: A Beginner's Guide by Lewis Dartnell
DNA is practically the same as RNA, differing only in an extra oxygen bonded to the ribose sugar ring and the use of the T base rather than the U. Both are composed of three parts: a sugar, a phosphate group which binds the sugars into a strand and the base. It is relatively easy to change the bases within a DNA strand; experiments have been performed to systematically substitute lab-made bases – changing the letters of the genetic alphabet. The structure of the DNA is not overly distorted, it still forms a double helix, despite the bonding between the base rungs being different. The reason why alien DNA probably would not use these non-standard alternatives is that they are less likely to be formed by the prebiotic processes thought to occur in interstellar gas clouds or on primordial planets. Most experiments into alternatives focus on RNA, as is it thought to pre-date DNA in the evolution of life. Terrestrial RNA is built from a five-carbon sugar (the ribose): two main modifications to this have been tested in the lab; either the bonds linking neighbouring sugars are attached to different carbon atoms within the ring or a different sugar molecule is used.
The bonding between the base pairs was woefully inadequate; not only was it very weak but the bases were much less particular about which they paired with – A would happily bond with G, rather than only withT. The larger sugar units are probably just too bulky and interfere with close bonding. The results from four-carbon sugars were much more exciting. The polymer TNA, made using the sugar threose, allows base pairing of a similar stability and accuracy to RNA and forms into a perfect double helix. TNA can even cross-pair with RNA and DNA, something that was impossible for most of the other alternatives. This has raised a lot of interest, due to the simpler nature of TNA, based as it is on a four-carbon sugar. Such a sugar would form more easily in prebiotic reactions and so TNA is much more likely to have arisen on the early Earth. The importance of this will become obvious in Chapter 4, when we look at the evolution of replicating molecules and the difficulties of explaining how DNA, or even RNA, ever appeared in the first place.
Fully Automated Luxury Communism by Aaron Bastani
"Robert Solow", autonomous vehicles, banking crisis, basic income, Berlin Wall, Bernie Sanders, Bretton Woods, capital controls, cashless society, central bank independence, collapse of Lehman Brothers, computer age, computer vision, David Ricardo: comparative advantage, decarbonisation, dematerialisation, Donald Trump, double helix, Elon Musk, energy transition, Erik Brynjolfsson, financial independence, Francis Fukuyama: the end of history, future of work, G4S, housing crisis, income inequality, industrial robot, Intergovernmental Panel on Climate Change (IPCC), Internet of things, Isaac Newton, James Watt: steam engine, Jeff Bezos, job automation, John Markoff, John Maynard Keynes: technological unemployment, Joseph Schumpeter, Kevin Kelly, Kuiper Belt, land reform, liberal capitalism, low earth orbit, low skilled workers, M-Pesa, market fundamentalism, means of production, mobile money, more computing power than Apollo, new economy, off grid, pattern recognition, Peter H. Diamandis: Planetary Resources, post scarcity, post-work, price mechanism, price stability, private space industry, Productivity paradox, profit motive, race to the bottom, RFID, rising living standards, Second Machine Age, self-driving car, sensor fusion, shareholder value, Silicon Valley, Simon Kuznets, Slavoj Žižek, stem cell, Stewart Brand, technoutopianism, the built environment, the scientific method, The Wealth of Nations by Adam Smith, Thomas Malthus, transatlantic slave trade, Travis Kalanick, universal basic income, V2 rocket, Watson beat the top human players on Jeopardy!, Whole Earth Catalog, working-age population
After Mendel, however, understanding genetic inheritance increasingly resembled a science rather than an art. By the middle of the twentieth century our knowledge of the field was so impressive that humans grasped how they might be able to accelerate a process seen throughout nature – evolution – inside a laboratory. While DNA was understood to be responsible for heredity from 1952, and Crick and Watson’s double helix model was formulated the following year, the first genetically-engineered animals weren’t produced until the early 1970s. That breakthrough was arguably as profound as the transistor, the integrated circuit and even Watt’s steam engine. Within just a few short decades theoretical science had become applied technology. While of widespread popular interest and the basis for innumerable Hollywood films, this historic leap had little immediate impact in the provision of healthcare.
See also specific crises Cuban, Mark, 90 cultured meat, 170–5 da Vinci surgery robot, 90 Das Kapital (Marx), 51–2 data storage, 45–6 decarbonisation, 100–1, 118, 198–9, 217–23 Deep Blue, 80, 81 Deep Space Industries (DSI), 132, 136–7 DeLong, J. Bradford, 64–5 dementia, 143 Dementia Tax, 142 democratic people, 187 Deutsche Bank, 103, 105 Deutscher, Isaac, 243 Diamandis, Peter, 129, 135, 136 diesel vehicles, 105 digitisation, 40 Discorsi (Machiavelli), 95 disruptions. See also specific disruptions energy and, 94–6 food, surplus and, 159–60 d.light, 109 DNA, 144, 147, 150, 151, 241–2 double helix model, 149 Doug, 7–8 Drucker, Peter, 51, 59–60, 79, 85, 232 dwarf planets, 130 E. coli, 148n Earth BioGenome Project, 146 East Coast Main Line, 203–4 economic globalisation, 197–8 economies relocalisation of, 207–8 worker-owned, 207–8, 211–12, 219 egg whites, cellular agriculture and, 177–9 Ehrlich, Paul, 167 The Population Bomb, 166 Eisenhower, Dwight, 136n, 137 elderly care, 92 electoral politics, 195 electoralism, society and, 194–6 elite technocracy, 185–8 Elysium (film), 154–8 Encyclopaedia Britannica, 235 Endless West, 180 Endogenous Technological Change (Romer), 63 ‘The End of History’ (Fukuyama), 15–17 The End of History and the Last Man (Fukuyama), 16 energy consumption of, 99–100 cost of storage technologies for, 105 disruption and, 94–6 free, 99–101 future of, 105–6 insulation of, 113–15 minimising consumption of, 220 post-scarcity in, 94–116 renewable (See renewable energy) solar, 101–5 wind, 111–13 energy transition, politics of, 218 Engels, Friedrich The Communist Manifesto, 51–2 England, 114.
The Autistic Brain: Thinking Across the Spectrum by Temple Grandin, Richard Panek
Asperger Syndrome, correlation does not imply causation, dark matter, David Brooks, deliberate practice, double helix, ghettoisation, if you see hoof prints, think horses—not zebras, impulse control, Khan Academy, Mark Zuckerberg, meta analysis, meta-analysis, mouse model, neurotypical, pattern recognition, phenotype, Richard Feynman, selective serotonin reuptake inhibitor (SSRI), Silicon Valley, Steve Jobs, theory of mind, twin studies
I remember in graduate school hearing about junk DNA. I heard references to it in the classroom. I saw peer-reviewed research articles about it in Science and Nature. Junk DNA is not a nickname, even though it may sound like one; it is an actual scientific term. It’s called junk DNA because, unlike the sequences of DNA that code for proteins, these sequences didn’t seem to have any purpose. That idea was ridiculous to me. The double helix had always reminded me of a computer program, and you would never write code that had a lot of unnecessary stuff. The “junk” had to serve a purpose. It had to be something like the gene’s operating system. If you go into your computer and find a lot of weird files, you might wonder what they’re for, but you wouldn’t conclude that they served no purpose. And you sure wouldn’t want to reverse a couple of zeros and ones just to see what happened.
In one common analogy, the earlier sequencing of the human genome by the Human Genome Project and by Craig Venter’s Celera Genomics in 2001 “was like getting a picture of Earth from space,” as one scientist told the Times, while Encode was like Google Maps: It told us “where the roads are,” “what traffic is like at what time of the day,” “where the good restaurants are, or the hospitals or the cities or the rivers.” The Human Genome Project told us what the genome was. Encode has begun to tell us what it does. But what really interested me was the article’s explanation of how the genome does what it does. In order to appreciate its significance, you first have to understand what DNA looks like. We’ve all seen the popular image of the double helix: that corkscrew of seemingly endless combinations of A (adenine), C (cytosine), G (guanine), and T (thymine) bases. But that Tinker Toy model represents a strand of DNA that’s stretched out. A strand of DNA completely unfurled would be about ten feet long. But it’s not unfurled. Instead, DNA is so tightly coiled that it fits inside the microscopic cell nucleus. By looking at DNA in its natural state, Encode researchers found, as the Times reported, “that small segments of dark-matter DNA are often quite close to genes they control.”
A Natural History of Beer by Rob DeSalle
This complementarity is critical for understanding both the beauty and the logic of DNA. Figure 5.1. Diagram of a short stretch of double helical DNA. There are four bases or nucleotides on each of the two strands of the double helix. The base pairing of the nucleotides (A with T, and G with C) is also shown. The left strand runs top to bottom from 5prime to 3prime, and the right strand runs top to bottom from 3prime to 5prime. Imagine two complementary strands of DNA, twenty bases in length. They will stick tightly to one another, and coil around each other in a double helix; and it is the order of the bases along them that will determine each individual molecule’s function. DNA works in pretty much the same way as our western alphabet, except that the “words” are only three letters long, and of course there are only four letters with which to work.
Fool Me Twice: Fighting the Assault on Science in America by Shawn Lawrence Otto
affirmative action, Albert Einstein, anthropic principle, Berlin Wall, Brownian motion, carbon footprint, Cepheid variable, clean water, Climategate, Climatic Research Unit, cognitive dissonance, Columbine, commoditize, cosmological constant, crowdsourcing, cuban missile crisis, Dean Kamen, desegregation, different worldview, double helix, energy security, Exxon Valdez, fudge factor, ghettoisation, global pandemic, Harlow Shapley and Heber Curtis, Harvard Computers: women astronomers, informal economy, Intergovernmental Panel on Climate Change (IPCC), invisible hand, Isaac Newton, Louis Pasteur, mutually assured destruction, Richard Feynman, Ronald Reagan, Saturday Night Live, shareholder value, sharing economy, smart grid, Solar eclipse in 1919, stem cell, the scientific method, The Wealth of Nations by Adam Smith, Thomas Kuhn: the structure of scientific revolutions, transaction costs, University of East Anglia, War on Poverty, white flight, Winter of Discontent, working poor, yellow journalism, zero-sum game
The “inquisition tyrannies” of the church’s crackdown in response to Galileo had “dampened the glory of Italian wits; that nothing had been there written, now these many years, but flattery and fustian.”10 By the end of the seventeenth century, as Anglican clergy in London were preaching Newton’s science, Italian scientists were standing trial in Naples for stating “that there had been men before Adam composed of atoms equal to those of other animals.”11 THE DNA OF WESTERN THOUGHT Each arm of this double helix of Western Christianity—Roman Catholicism and the emerging Protestantism—embodied the two distinctly different worldviews of the authoritarian and the antiauthori-tarian: that rules and methods were either proscribed from on high or built up by individuals in consensus. These two views had always been present, but they were greatly amplified in 1517, when Martin Luther posted his Ninety-Five Theses* challenging church authorities to debate principles that seemed defensible only by virtue of the church’s authority over its subjects.
After the war, the feeling that our ability with science had outstripped our moral and ethical development as a society, perhaps as a species, was not limited to physicists, but rather was spread across the sciences. The Austrian Jewish biochemist Erwin Chargaff immigrated to the United States to escape the Nazis in 1935. His work would lead to James Watson and Francis Crick’s discovery of the double-helix structure of DNA. Chargaff’s autobiography described his changed feelings about science. The double horror of two Japanese city names [Hiroshima and Nagasaki] grew for me into another kind of double horror: an estranging awareness of what the United States was capable of, the country that five years before had given me its citizenship; a nauseating terror at the direction the natural sciences were going.
His early papers were extensions of the work of Max Planck, the Austrian physicist Ludwig Boltzmann, and others, and his revolutionary findings on Brownian motion were independently discovered by Polish physicist Marian von Smoluchowski, who was also building on Boltzmann’s work. Hubble’s revolutionary discovery of the expansion of the universe also extended from ideas that were talked about for years. The redshift was first noted by American astronomer Vesto Slipher in 1912—nearly two decades before Hubble’s discovery. Galileo’s revolution was an extension of Copernicus’s writings of some seventy years before, which were widely discussed. The discovery of the double-helix structure of DNA was revolutionary, but it too was an extension, building on the work of biochemist Erwin Chargaff. It is true that science does not proceed linearly; it proceeds more like a pack of dogs sniffing out a fox, but that is because of its trial-and-error, observational approach that adopts whatever new tools become available, applies metaphor, builds on the latest recorded knowledge (“the literature,” as scientists call it), and makes and tests bold predictions to better see the reality of the thing instead of our prejudices or assumptions or beliefs or opinions or hopes and dreams.
Evil Genes: Why Rome Fell, Hitler Rose, Enron Failed, and My Sister Stole My Mother's Boyfriend by Barbara Oakley Phd
agricultural Revolution, Alfred Russel Wallace, Barry Marshall: ulcers, cognitive dissonance, conceptual framework, corporate governance, Deng Xiaoping, double helix, impulse control, Mahatma Gandhi, meta analysis, meta-analysis, Milgram experiment, Norbert Wiener, phenotype, Ponzi scheme, prisoner's dilemma, Richard Feynman, rolodex, Ronald Reagan, Silicon Valley, Stanford prison experiment, Steven Pinker, The Wisdom of Crowds, Thomas Kuhn: the structure of scientific revolutions, twin studies, union organizing, Y2K
That means that the average chromosome is a couple of inches long—which makes a DNA strand a giant, as molecules go. But because DNA is extraordinarily slender—thousands of times thinner than a hair—all forty-six human chromosomes are easily wadded up like a molecular-sized ball of string inside the cell's nucleus. Fig. 3.1. The 46 human chromosomes DNA molecules are not only long and skinny but also very simple in structure. The famous DNA “double helix” consists of two parallel (but twisted) chains of molecular building blocks called nucleotides. There are only four kinds of nucleotides, and what makes the four different from one another are parts of the nucleotides called bases—adenine, guanine, thymine, and cytosine. The four DNA bases are almost always abbreviated A, G, T, and C. The DNA “code” consists of sequences of nucleotides with various bases.
Judith Rich Harris, author of The Nurture Assumption, gave me gentle impetus at the beginning of this project—for her graciousness I am utterly grateful. I could not have written this book if she had not “broken trail.” At Prometheus Books, Julia DeGraf's copy-editing skills are remarkable, and deeply appreciated. Grace Zilsberger's cover design is inspired (those who look closely might spot the DNA double-helix on the snake's back). Chris Kramer, Jill Maxick, Rich Snyder, Gretchen Kurtz, Mark Hall, Marcia Rogers, Bruce Carle, and Lynn Pasquale round out the crew of consummate Prometheus professionals who I've been fortunate indeed to work with. No question—Prometheus president Jonathan Kurtz runs a taut ship. At Oakland University, my dean, Pieter Frick, and department chair, Chris Wagner, have provided congenial support and encouragement, as have my “part-time” department chairs, Manohar Das and Gary Barber.
Brackman, A Delicate Arrangement: The Strange Case of Charles Darwin and Alfred Russel Wallace (New York: Times Books, 1980), p. 124. 10. Ross A. Slotten, The Heretic in Darwin's Court: The Life of Alfred Russel Wallace (New York: Columbia University Press, 2004), p. 159. 11. Brackman, Delicate Arrangement, p. 34. 12. Michael Shermer, In Darwin's Shadow: The Life and Science of Alfred Russel Wallace: A Biographical Study on the Psychology of History (New York: Oxford University Press, 2002). 13. James D. Watson, The Double Helix: A Personal Account of the Discovery of the Structure of DNA (New York: Penguin, 1970). Watson's appalling mischaracterization of Rosalind Franklin is well described in Brenda Maddox, Rosalind Franklin: The Dark Lady of DNA (New York: HarperPerennial, 2003). 14. Shreeve, Genome War, p. 85. 15. Joel N. Shurkin, Broken Genius: The Rise and Fall of William Shockley, Creator of the Electronic Age (New York: Macmillan, 2006), p. 126. 16.
The Age of Spiritual Machines: When Computers Exceed Human Intelligence by Ray Kurzweil
Ada Lovelace, Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Albert Einstein, Any sufficiently advanced technology is indistinguishable from magic, Buckminster Fuller, call centre, cellular automata, combinatorial explosion, complexity theory, computer age, computer vision, cosmological constant, cosmological principle, Danny Hillis, double helix, Douglas Hofstadter, Everything should be made as simple as possible, first square of the chessboard / second half of the chessboard, fudge factor, George Gilder, Gödel, Escher, Bach, I think there is a world market for maybe five computers, information retrieval, invention of movable type, Isaac Newton, iterative process, Jacquard loom, John Markoff, John von Neumann, Lao Tzu, Law of Accelerating Returns, mandelbrot fractal, Marshall McLuhan, Menlo Park, natural language processing, Norbert Wiener, optical character recognition, ought to be enough for anybody, pattern recognition, phenotype, Ralph Waldo Emerson, Ray Kurzweil, Richard Feynman, Robert Metcalfe, Schrödinger's Cat, Search for Extraterrestrial Intelligence, self-driving car, Silicon Valley, social intelligence, speech recognition, Steven Pinker, Stewart Brand, stochastic process, technological singularity, Ted Kaczynski, telepresence, the medium is the message, There's no reason for any individual to have a computer in his home - Ken Olsen, traveling salesman, Turing machine, Turing test, Whole Earth Review, Y2K
Let’s first consider the intelligent process that created us: evolution. Evolution is a master programmer. It has been prolific, designing millions of species of breathtaking diversity and ingenuity And that’s just here on Earth. The software programs have been all written down, recorded as digital data in the chemical structure of an ingenious molecule called deoxyribonucleic acid, or DNA. DNA was first described by J. D. Watson and E H. C. Crick in 1953 as a double helix consisting of a twisting pair of strands of polynucleotides with two bits of information encoded at each ledge of a spiral staircase, encoded by the choice of nucleotides.1 This master “read only” memory controls the vast machinery of life. Supported by a twisting sugar-phosphate backbone, the DNA molecule consists of between several dozen and several million rungs, each of which is coded with one nucleotide letter drawn from a four-letter alphabet of base pairs (adenine-thymine, thymine-adenine, cytosine-guanine, and guanine-cytosine).
How does DNA accomplish its work? These questions would be answered in 1953 by James D. Watson and Francis H. C. Crick.Watson and Crick wrote “The Molecular Structure of Nucleic Acid: A Structure for Deoxyribose Nucleic Acid” published in the April 25, 1953 issue of Nature. For more information on the race by various research groups to discover the molecular structure of DNA, read Watson’s book, The Double Helix (New York: Atheneum Publishers, 1968). 2 Translation starts by unwinding a region of DNA to expose its code. A strand of messenger RNA (mRNA) is created by copying the exposed DNA base-pair codes. The appropriately named messenger RNA records a copy of a portion of the DNA letter sequence and travels out of the nucleus into the cell body There the mRNA encounters a ribosome molecule, which reads the letters encoded in the mRNA molecules and then, using another set of molecules called transfer RNA (tRNA), actually builds protein chains one amino acid at a time.
A Logical Journey: From Gödel to Philosophy. Cambridge, MA: MIT Press, 1996. Warrick, Patricia S. The Cybernetic Imagination in Science Fiction. Cambridge, MA: MIT Press, 1980. Watanabe, Satoshi. Pattern Recognition: Human and Mechanical. New York: John Wiley and Sons, 1985. Waterman, D. A. and E Hayes-Roth, eds. Pattern-Directed Inference Systems. Out of print. Watson, J. B. Behaviorism. New York: Norton, 1925. Watson, J. D. The Double Helix. New York: Atheneum, 1968. Watt, Roger. Understanding Vision. London: Academic Press, 1991. Webber, Bonnie Lynn and Nils J. Nilsson, eds. Readings in Artificial Intelligence. Los Altos, CA: Morgan Kaufmann, 1981. Weinberg, Steven. Dreams of a Final Theory. New York: Pantheon Books, 1992. _________. The First Three Minutes: A Modern View of the Origin of the Universe. New York: Pantheon Books, 1977.
Beautiful Data: The Stories Behind Elegant Data Solutions by Toby Segaran, Jeff Hammerbacher
23andMe, airport security, Amazon Mechanical Turk, bioinformatics, Black Swan, business intelligence, card file, cloud computing, computer vision, correlation coefficient, correlation does not imply causation, crowdsourcing, Daniel Kahneman / Amos Tversky, DARPA: Urban Challenge, data acquisition, database schema, double helix, en.wikipedia.org, epigenetics, fault tolerance, Firefox, Hans Rosling, housing crisis, information retrieval, lake wobegon effect, longitudinal study, Mars Rover, natural language processing, openstreetmap, prediction markets, profit motive, semantic web, sentiment analysis, Simon Singh, social graph, SPARQL, speech recognition, statistical model, supply-chain management, text mining, Vernor Vinge, web application
Now that’s what I call fault-tolerant and redundant storage. 243 Download at Boykma.Com Almost every cell in your body contains a central data center, which stores these genomic databases, called the nucleus. Within this are the chromosomes. Like all humans, you are diploid, with two copies of each chromosome, one from your father and one from your mother. Added to these are the sex chromosomes, two X chromosomes for a female, or an X and a Y chromosome for a male. The primary components of these genetic data stores are two strands of DNA, intertwined in the charismatic double helix, as seen in Figure 15-1. F I G U R E 1 5 - 1 . A short section of DNA, rendered in POV-Ray from PDB file 1BNA, doi: 10.2210/pdb1bna/pdb. (See Color Plate 51.) Each strand of DNA is made up of a chain of bases. There are four bases in DNA—Adenine, Guanine, Cytosine, Thymine (or A, G, C, and T)—and it is in this quaternary system that the database is encoded. In humans, there are 3 gigabases of DNA present in two slightly different copies. 244 CHAPTER FIFTEEN Download at Boykma.Com DNA Makes RNA Makes Proteins What is DNA for, exactly?
They also contain systems that detect when a disk has been damaged and alert the user (e.g., SMART monitoring). For additional reliability, you might mirror one hard drive on another in a RAID1 array. With two hard drives that should be identical, if one goes wrong it can be replaced with another and the data put back. The cell contains its own machinery to detect and repair DNA damage. Recall that the DNA molecule exists as a double helix, with each base on one strand complementary to the matching base on the other. If damage is done to one strand, it can be repaired by using the other as a template (the RAID1 approach). Other mechanisms exist to repair more extensive damage. 246 CHAPTER FIFTEEN Download at Boykma.Com If the damage cannot be repaired, then the tumor suppressor genes kick in, preventing cell division, and ultimately initiating programmed cell death, and hopefully the cell can be replaced (the SMART approach).
They are complementary: each of the four bases of DNA has a complement (A complements G, and C complements T) that appears opposite it on the other strand. Watson and Crick noticed this in the now famous understatement in their paper revealing this structure of DNA: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” Each DNA strand is a template for the other, so to make copies of a double helix, the cell can separate the two and build up a new strand on each template using each base’s complement. When a cell divides to make two new cells, this is exactly what happens (see Figure 15-3). New strand New strand DNA replication G C T A F I G U R E 1 5 - 3 . DNA replication proceeds by using the original two strands (white) as templates for two new strands (black), resulting in two new double-stranded molecules (image from http://genome.gov/glossary.cfm).
Is God a Mathematician? by Mario Livio
Albert Einstein, Antoine Gombaud: Chevalier de Méré, Brownian motion, cellular automata, correlation coefficient, correlation does not imply causation, cosmological constant, Dava Sobel, double helix, Edmond Halley, Eratosthenes, Georg Cantor, Gerolamo Cardano, Gödel, Escher, Bach, Henri Poincaré, Isaac Newton, Johannes Kepler, John von Neumann, music of the spheres, Myron Scholes, probability theory / Blaise Pascal / Pierre de Fermat, Russell's paradox, Thales of Miletus, The Design of Experiments, the scientific method, traveling salesman
Deoxyribonucleic acid, or DNA, is the genetic material of all cells. It consists of two very long strands that are intertwined and twisted around each other millions of times to form a double helix. Along the two backbones, which can be thought of as the sides of a ladder, sugar and phosphate molecules alternate. The “rungs” of the ladder consist of pairs of bases connected by hydrogen bonds in a prescribed fashion (adenine bonds only with thymine, and cytosine only with guanine; figure 58). When a cell divides, the first step is replication of DNA, so that daughter cells can receive copies. Similarly, in the process of transcription (in which genetic information from DNA is copied to RNA), a section of the DNA double helix is uncoiled and only one DNA strand serves as a template. After the synthesis of RNA is complete, the DNA recoils into its helix.
NeoAddix by Jon Courtenay Grimwood
Digitized somewhere, gathering the binary equivalent of dust in a C3N CySat databank. While Maxine slept, tonight’s news was happening closer to home, down on the banks of the River Seine, where time froze and then stopped for Parisian tramp Louis Lepan as steel fingernails reached for his throat. For once the dim starlight was not washed out by the glare of Coca Cola’s revolving hologram, nor by the neon cross & double helix of the Church Geneticist. Communard terrorists had blown up the Rue Jacob substation, leaving darkness. The Prince smiled, an old man’s grin. He at least welcomed that night’s power cut… Spearing quickly through krycoid cartilage, the Prince’s fingers closed on the gnarled, stick-like column of the tramp’s upper spine and snapped it like a twig. Lepan dropped, a twitching heap of filthy rags, his opened throat bright as a scarf whose ends flowed over the cobbles, melting frost as they went.
Johnnie knew that, because he’d had time to watched it happen before the surgery’s wall-mounted flat screen Toshiba exploded in the heat, showing him with shards of crystal polycarbon. Once free of the slab, he’d grabbed a blue scrub suit to cover his frozen body and decided to get out of there, fast. The fire fighters weren’t a problem, they parted respectfully enough when they spotted the cross and double helix on his borrowed scrub suit, hustling him out to the safety of the open courtyard. Johnnie was actually safely out through the main gate into the teeming crowd outside when the first police hover screamed towards him along Rashid Street, loudspeaker blaring. As the crowd around him thinned like wind-blown smoke, Johnnie found himself briefly outlined in the halogen beam of a police searchlight and tumbled sideways on instinct, rolling safely back inside the courtyard as a slug of recycled rubber whistled over his head.
Red Plenty by Francis Spufford
affirmative action, anti-communist, Anton Chekhov, asset allocation, Buckminster Fuller, clean water, cognitive dissonance, computer age, double helix, Fellow of the Royal Society, John von Neumann, Kickstarter, Kitchen Debate, linear programming, market clearing, MITM: man-in-the-middle, New Journalism, oil shock, Philip Mirowski, plutocrats, Plutocrats, profit motive, RAND corporation, Simon Kuznets, the scientific method
That is, when the lung cell is already busy dividing into two lung cells. The goo floats in, and finds inside the nucleus a double helix which has been unzipped into two separate strands, each of which is going to grow back into a complete copy of the genome. Of all the random blobs of goo in the random rainstorm, here comes the blob that suckers onto Chromosome 11 in the position to create the always-on version of ras, just as the unzipped halves of Chromosome 11 are waving loose. It’s too late for the editorial enzyme: there’s nothing to correct the mutant C against. Along the strand instead travels a polymerase, a construction enzyme, steadily building out the other half of a new double helix. And when it reaches the C, it obligingly supplies a new counterpart for the other side which is a match, which is a perfect opposite.
But it’s the switch that has been altered by having C where G used to be in this mutant version of ras. C instead of G at this one particular point jams the ras gene at ‘on’ – throws the lever for unstoppable growth, and then breaks the lever. But it’s all right. This copy of ras may be corrupted, but the cell has a failsafe mechanism built into the shape of the DNA molecules. The helix is a double helix. On the other side of the double corkscrew there runs another strand of Gs, Ts, Cs and As which carries all the information of the genome, only in reverse, like the negative of a photograph or the mould a jelly was turned out of; and the cell, which is used to operating in an environment of small chemical accidents, operates a handy editorial enzyme that moves up and down the chromosomes checking that the two strands remain perfect opposites.
QI: The Second Book of General Ignorance by Lloyd, John, Mitchinson, John
Ada Lovelace, Boris Johnson, British Empire, Buckminster Fuller, Captain Sullenberger Hudson, Charles Lindbergh, clean water, double helix, Etonian, George Santayana, ghettoisation, Isaac Newton, Lao Tzu, Louis Pasteur, Mikhail Gorbachev, Murano, Venice glass, out of africa, the built environment, trade route, transatlantic slave trade, traveling salesman, US Airways Flight 1549
What’s more, the staircase trick wouldn’t work: if a defender was left-handed then an anticlockwise staircase would indeed allow him to use his sword more effectively, but it would also give a right-handed attacker the same advantage. So, a staircase that twisted the other way would only be useful when defending against another Kerr (not impossible given their bloodthirsty reputation). The Chateau de Chambord in the Loire Valley has a double-helix staircase: two staircases which wind around each other so that people going up don’t bump into people coming down – and the cliff-top fortifications at Dover have a triple-helix staircase (known as the ‘Grand Shaft’) designed to get three columns of troops down to harbour level simultaneously. The most famous of all double helixes is the molecule called deoxyribonucleic acid, better known as DNA. Francis Crick and James Watson first described its structure in 1953, although they were inspired by an X-ray photograph of DNA taken by Rosalind Franklin (1920–58), who almost beat them to it.
Originals: How Non-Conformists Move the World by Adam Grant
Albert Einstein, Apple's 1984 Super Bowl advert, availability heuristic, barriers to entry, business process, business process outsourcing, Cass Sunstein, clean water, cognitive dissonance, creative destruction, cuban missile crisis, Daniel Kahneman / Amos Tversky, Dean Kamen, double helix, Elon Musk, fear of failure, Firefox, George Santayana, Ignaz Semmelweis: hand washing, Jeff Bezos, job satisfaction, job-hopping, Joseph Schumpeter, Kickstarter, Lean Startup, Louis Pasteur, Mahatma Gandhi, Mark Zuckerberg, meta analysis, meta-analysis, minimum viable product, Nelson Mandela, Network effects, pattern recognition, Paul Graham, Peter Thiel, Ralph Waldo Emerson, random walk, risk tolerance, Rosa Parks, Saturday Night Live, Silicon Valley, Skype, Steve Jobs, Steve Wozniak, Steven Pinker, The Wisdom of Crowds, women in the workforce
When companies run suggestion boxes, there is evidence that older employees tend to submit more ideas and higher-quality ideas than their younger colleagues, with the most valuable suggestions coming from employees older than fifty-five. And in technology startups that have raised venture capital funding, the average founder is thirty-eight. In the arts and sciences, Chicago economist David Galenson shows that although we’re quick to remember the young geniuses who peak early, there are plenty of old masters who soar much later. In medicine, for every James Watson, who helped to discover the double helix structure of DNA at age twenty-five, there is a Roger Sperry, who identified different specializations between the right and left hemispheres of the brain at age forty-nine. In film, for every Orson Welles, whose masterpiece Citizen Kane was his very first feature film at age twenty-five, there is an Alfred Hitchcock, who made his three most popular films three decades into his career, at ages fifty-nine (Vertigo), sixty (North by Northwest), and sixty-one (Psycho).
And in an independent study of every physicist who has ever won the Nobel Prize, of the young geniuses under thirty, exactly half were conceptual innovators who did theoretical work. Among the old masters forty-five and above, 92 percent did experimental work. These fundamental differences between conceptual and experimental innovators explain why some originals peak early and others bloom late. Conceptual innovation can be done quickly, because it doesn’t require years of methodical investigation. When Watson and Crick discovered the double helix structure of DNA, they didn’t need to wait for data to amass. They had built a three-dimensional theoretical model and examined X-ray images provided by Rosalind Franklin. In addition, conceptual breakthroughs tend to occur early, because it is easiest to come up with a strikingly original insight when we approach a problem with a fresh perspective. “Conceptual innovators normally make their most important contributions to a discipline not long after their first exposure to it,” Galenson finds.
She Has Her Mother's Laugh by Carl Zimmer
23andMe, agricultural Revolution, clean water, clockwatching, cloud computing, dark matter, discovery of DNA, double helix, Drosophila, Elon Musk, epigenetics, Fellow of the Royal Society, Flynn Effect, friendly fire, Gary Taubes, germ theory of disease, Isaac Newton, longitudinal study, medical bankruptcy, meta analysis, meta-analysis, microbiome, moral panic, mouse model, New Journalism, out of africa, phenotype, Ralph Waldo Emerson, Scientific racism, statistical model, stem cell, twin studies
Franklin and Gosling published their X-ray data in another paper, which seemed to readers to be a “me-too” effort. Franklin died of cancer five years later, while Crick, Watson, and Wilkins went on to share the Nobel prize in 1962. In his 1968 book, The Double Helix, Watson would cruelly caricature Franklin as a belligerent, badly dressed woman who couldn’t appreciate what was in her pictures. That bitter fallout is a shame, because these scientists had together discovered something of exceptional beauty. They had found a molecular structure that could make heredity possible. DNA, they discovered, is a pair of strands twisted into a double helix. Between the strands, a series of compounds called bases bonded to each other. Over the next thirty years, scientists worked out how this structure allowed DNA to carry genes. Each gene is a stretch of DNA, made up of thousands of bases.
To find out about my own inheritance, I took my genome to the place where the study of human heredity had gotten off to such a dubious start: Cold Spring Harbor. * * * — One sunny late-winter day, I drove down Bungtown Road, along the southern edge of the Long Island Sound, and then climbed a high hill to reach the lab. I parked my car and used a map to navigate my way past a bell tower. The tower housed a staircase in the shape of a DNA double helix. The letters of the four bases, a, c, g, and t, were engraved high on its four walls. I shuffled down broad steps to a cluster of research buildings. Inside one of them I found the office of a young scientist named Adam Siepel. He welcomed me in and had me sit at a table below a giant monitor bolted to a wall. Siepel had a high forehead and kept his hair cropped to near-baldness. He kept a miniature rock garden on a shelf by his desk, a rivulet running through the center and making an endless burble.
See also feeblemindedness Crick, Francis, 124–25 CRISPR/Cas system and Drosophila research, 550–54 early research on, 488–91 and ethical issues of scientific advances, 542 and genetic vs. nongenetic heredity, 474 and human genome editing, 495–97, 523–34, 560–61 impact on human gene pool, 537–40, 565 and microbial immune systems, 143–44 and mosquito control research, 557–58, 570–74 and plant domestication, 493–94 Crohn’s disease, 535, 538 Cro-Magnons, 236–37 Crumbling Genome (Kondrashov), 540 cultural history and inheritance and environmental impact of humans, 570–71 human cumulative culture, 460, 463, 465–66, 468–69, 562–65, 567 and imitation, 445–51, 463–65 and intelligence research, 292 and learning, 454–59, 459–66 and memes, 452–54 and non-genetic inheritance, 471–80 Cushing, Harvey, 274 cystic fibrosis, 503, 535 Danbury, Lewis, 104 Dar-Nimrod, Ilan, 317–18 Darnovsky, Marcy, 528 Darwin, Charles and epigenetics, 435, 442 and Galton’s plant breeding experiments, 260 and modern concept of heredity, 6, 43–56, 58–62, 426 and recessive traits, 473 research on bud sports, 349 and Weismann’s germ line research, 328, 409 Das Erbe (film), 94–95 Davenport, Charles, 79–81, 84–85, 93, 99, 100, 200–202, 234–35, 499 Davenport, Gertrude, 80, 201–2 Davidson, Ronald, 338 Dawkins, Richard, 452–53 Day, Troy, 474–78 Dean, Lewis, 459–60 Deary, Ian, 293–96, 302–3 Delbrück, Max, 551 DeLong, Robert, 307–8 De morbis hereditariis—On Hereditary Diseases (Mercado), 24, 27 dengue fever, 1, 555 Denisovans, 247–49, 465 Desai, Michael, 149–50 Desai, Rajendra, 385 d’Este, Isabella, 254 devil face tumor disease, 392–400 de Vries, Hugo, 29–31, 60–62, 64, 79, 125–26, 424, 426 diabetes, 211, 216–17, 250–51, 273, 276, 278 Dias, Brian, 428–30, 434, 437 Díaz de Games, Gutierre, 18 Dictionary of Races or Peoples (Thomas), 211 Dinka people, 229–30 Dishley Grange, 33–35 DNA (deoxyribonucleic acid) and bacterial restriction enzymes, 487–88 and beneficial mutations, 149 and carbon-14 dating, 346 and causes of PKU, 129 and chimerism, 380–84, 388, 391, 393, 396–98 and CRISPR research, 488–91, 538–40, 566 and cumulative culture, 465 and Dawkins’s meme concept, 452 and diagnosis of hereditary diseases, 133 and discovery of genes, 123–26 and effects of meiosis on heredity, 150–52 and embryonic development, 333 and epigenetics, 430–31, 433, 436–41 and ethical issues of scientific advances, 542 and family genealogies, 160 fingerprinting, 381 and gene drives, 155, 572–73 and gene therapy, 509, 512 and genetic engineering, 507–8 and genetic screening, 503–5 and genetic testing and counseling, 3–4, 6–7 and genetic vs. nongenetic heredity, 472, 475, 479 and genome sequencing, 182–85 and height research, 251, 273, 275–77, 284 and human ancestral lines, 175–81, 186–93, 197, 216–20 and human genome editing, 495–97 and human germ line engineering, 523–28, 530–31 and human/Neanderthal interbreeding, 240–49 and intelligence research, 300, 301–4, 311, 317, 319 and interbreeding of human populations, 231–34, 240 and light organs, 406 and lyonization, 338–39 and mechanism of heredity, 427 and meiosis, 145–47, 151–53 and Mendel’s Law, 473 and microbial immune systems, 323 and microbiomes, 409, 412 and mosaicism, 353–55, 357–60, 363–64, 366–67, 369 and mosquito control research, 555–60 and Muller’s Germinal Choice, 502 and mutagenic chain reaction, 552, 554 and Nazi racism, 497–98 of Neanderthals, 238–40 and neuronal cells, 343 and ooplasm transfers, 514–15 origins of DNA-based life, 138–42 and paleogenetics, 225–28 and the Peloria plant, 424–25 and plant domestication, 494 and preimplantation genetic diagnosis, 535–37 and radiation damage, 333 and RFMix, 222–24 and selective breeding, 484–85 and skin color, 230–31 and spread of genetic variations, 207, 209 of Taita thrushes, 214–15 and totipotent cells, 341–42 and twin studies, 266–67 and in vitro gametogenesis, 547–49 See also mitochondria and mitochondrial DNA DNA Land database, 186–87 Dobzhansky, Theodosius, 204–7 A Domestic Treatise on the Diseases of Horses and Dogs (Blaine), 395 Donnelly, Peter, 215 dopamine, 301 The Double Helix (Crick, Watson, and Wilkins), 125 Doudna, Jennifer, 488–90, 496–97, 523–27, 530, 561 Douglass, Frederick, 166, 197–98, 267 Down syndrome, 1–2, 386 Drake, Francis, 255 Drosophila research, 97–98, 147, 149, 153–54, 204–10, 550–55, 557 DSCF5 gene, 244 Du Bois, W. E. B., 202–4 Duchenne muscular dystrophy, 340 Dunlap, Knight, 100–101 Dunn, Rob, 412 Dunsford, Ivor, 377, 379 Dutton, Warren, 51 Dwarf Alberta spruce, 348–49 dwarfism, 118, 253–54, 272, 278, 306 dystrophin, 340 Eanes de Azurara, Gomes, 20 East, Edward, 205–6 East Wind: West Wind (Buck), 111 E. coli, 140 ecological inheritance, 562–63, 565 Edge, Michael, 213 Edison, Thomas, 30 Edwards, Robert, 504–5, 509 “The Effects of Race Intermingling” (Davenport), 202 Egan, Michael, 301–2 Egeland, Borgny, 115–17 Egeland, Liv, 115 eggs, 419–20, 513–20, 527–28.
The Open Revolution: New Rules for a New World by Rufus Pollock
Airbnb, discovery of penicillin, Donald Davies, Donald Trump, double helix, Hush-A-Phone, informal economy, Internet of things, invention of the wheel, Isaac Newton, Kickstarter, Live Aid, openstreetmap, packet switching, RAND corporation, Richard Stallman, software patent, speech recognition
But today we do: he meant that he and his colleague James Watson, had discovered the structure of DNA, the substance within the cells of all animals, including humans, that carries the genetic code. This is the coding for every cell in our body, determining everything from the colour of our hair to the functioning of our kidneys. Watson and Crick had shown that it takes the form of two long sequences of four bases or “letters” – A, C, G, T – woven together in a double helix. (The sequence of 3 billion bases is so long that if you scaled up DNA to the width of a cotton thread, it would extend for nearly 200km.) Within this sequence there are much shorter strings of letters that form the recipe for each protein, and these substrings are called “genes”. Within the DNA sequence, there are millions of genes, separated by chunks of “junk” DNA – junk because it does not do anything (or, at least, we don’t yet know what it does).
Geektastic: Stories From the Nerd Herd by Holly Black, Cecil Castellucci
Neither of us missed a question, so it became a test of buzzer willpower. I started to ring in a split-second before I knew the answer. And I always knew the answer. Until I did the unthinkable. I buzzed in for a science question. Which Nobel prize winner later went on to write The Double Helix and Avoid Boring People? I realized immediately it wasn’t Saul Bellow or Kenzaburo Oe. As the judge said, “Do you have an answer?” the phrase TheDoubleHelix hit in my head. “Crick!” I exclaimed. The judge looked at me for a moment, then down at his card. “That is incorrect. Clearwater, which Nobel prize winner later went on to write The Double Helix and Avoid Boring People?” It was not the lit girl who buzzed in. “James D. Watson,” one of the math boys answered snottily, the D sent as a particular fuck you to me. “Sorry,” I whispered to my team. “It’s okay,” Damien said.
The Man Who Loved China: The Fantastic Story of the Eccentric Scientist Who Unlocked the Mysteries of the Middle Kingdom by Simon Winchester
Berlin Wall, British Empire, David Attenborough, Deng Xiaoping, double helix, Etonian, Fellow of the Royal Society, index card, invention of gunpowder, Jarndyce and Jarndyce, New Urbanism, Ralph Waldo Emerson, stakhanovite, Stephen Hawking, Ted Kaczynski, trade route
Needham decided to wear his long blue Chinese gown, the color blue having been regarded in imperial days in China as recognition of a high level of achievement, matching the high level of achievement in Britain that was suggested by the portrait itself. The older portraits under which members of the college dine are of ruffled, velvet-clad divines; Needham is among the more recent, and above him in his eastern getup are stained-glass windows depicting, not people, but the actual achievements made by other Caians—a colored-glass Venn diagram, and a delicately rendered double helix of DNA, conceptualized by Rosalind Franklin, James Watson, and Caius College’s Francis Crick. Needham’s retirement from the mastership came in 1976, and with it came the beginnings of a slow and steady downward spiral. For the first time Needham was beginning to realize—and, moreover, to admit—that he might not manage to cover the entirety of Chinese science within the limits of his lifetime.
., 53, 54, 57, 164 Cullen, Christopher, 251 Cultural Revolution (1966–1976), 231, 234, 235 names given to children during, 40n.7 Czechoslovakia, “Prague Spring” in (1968), 231 Dadu River, 85, 186 Daily Worker (Britain), 57 Daoism, 191, 192 Daquan River, 129 Darwinism, 13, 14 Deng Xiaoping (Chinese Communist leader), 237 Diamond Sutra, 101–2, 131, 138–39 Dictionary of National Biography (DNB), 230n.51 Diebold, John, 248, 249 dinosaur fossil Lufengosaurus, 156 DNA (deoxyribonucleic acid), double helix model of, 240 Dong Zhongshu, 168 Driberg, Tom, 233 Dujiangyan irrigation project, 108, 109 Dunhuang oasis and caves, 101, 102, 105, 128–32, 134–39 East Asian History of Science trust, 243–44 Eden, Anthony, 56 Eggleston, Frederick, 87 elements, five Chinese, 168 Elers, Peter, 233 Ellis, Havelock, 32 Emblica officinalis, 155 encyclopedia, imperial Chinese, 176–77 English Gymnosophist Society, 22 Epidemic Prevention Bureau, Lanzhou, China, 122 erotic texts, Chinese Daoist, 192 explorations, Chinese seagoing, 186, 194 extraterritoriality as legal concept, 72n.14 Far Eastern Survey, 228 Far East War Council, 54 Fessel, Klaus, 196 Fire-Drake Manual, The 199 Fisher, Ronald, 179–80 fishing reel, Chinese, 186 Fitch, James, 196 Foot, Dingle, 32 foot-binding practice in China, 119–20 Forster, E.
Soonish: Ten Emerging Technologies That'll Improve And/or Ruin Everything by Kelly Weinersmith, Zach Weinersmith
2013 Report for America's Infrastructure - American Society of Civil Engineers - 19 March 2013, 23andMe, 3D printing, Airbnb, Alvin Roth, augmented reality, autonomous vehicles, connected car, double helix, Elon Musk, en.wikipedia.org, Google Glasses, hydraulic fracturing, industrial robot, information asymmetry, Kickstarter, low earth orbit, market design, megastructure, microbiome, moral hazard, multiplanetary species, orbital mechanics / astrodynamics, personalized medicine, placebo effect, Project Plowshare, QR code, Schrödinger's Cat, self-driving car, Skype, stem cell, Tunguska event
To understand how all this might happen, you need to know a little about DNA. Let’s do a quick rundown. DNA In all multicellular organisms (like mushrooms and humans), cells have a distinct inner portion called a nucleus. Inside the nucleus are really long molecules called DNA. You can think of DNA as an especially lengthy rope ladder that twists around and around in a corkscrew shape. This is the famous “double helix.” The “rungs” of the ladder are made of two small molecules (one from each side) that fit into each other, hand in glove. Well, maybe we should say hand in glove or foot in shoe, since there are two ways these pairings happen. These small molecules are called bases, and they come in four types, abbreviated T, A, C, and G. Base T always pairs with A (hand in glove), and C always pairs with G (foot in shoe).
., and Rosholt, Robert L. NASA Historical Data Book, 1958–1968. Vol I: NASA Resources. Washington, D.C.: NASA, 1976. history.nasa.gov/SP-4012v1.pdf. Vasudevan, T. M., van Rij, A. M., Nukada, H., and Taylor, P. K. “Skin Wrinkling for the Assessment of Sympathetic Function in the Limbs.” Australian and New Zealand Journal of Surgery 70, no. 1 (2000):57–59. Venter, J. C. Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life. New York: Penguin Books, 2014b. ———. What—Me Worry?, 200–07. In What Should We Be Worried About?: Real Scenarios That Keep Scientists Up at Night, edited by J. Brockman. New York: Harper Perennial, 2014a. Vrije Universiteit Science. “Robot Baby Project by Prof.dr. A.E. Eiben on evolving robots / The Evolution of Things.” May 26, 2016. youtube.com/watch?v=BfcVSb-Q8ns.
The Human Age: The World Shaped by Us by Diane Ackerman
23andMe, 3D printing, additive manufacturing, airport security, Albert Einstein, augmented reality, back-to-the-land, carbon footprint, clean water, dark matter, dematerialisation, double helix, Drosophila, epigenetics, Google Earth, Google Glasses, haute cuisine, Internet of things, Loebner Prize, Louis Pasteur, Masdar, mass immigration, megacity, microbiome, nuclear winter, personalized medicine, phenotype, Ray Kurzweil, refrigerator car, Search for Extraterrestrial Intelligence, SETI@home, skunkworks, Skype, stem cell, Stewart Brand, the High Line, theory of mind, urban planning, urban renewal, Whole Earth Catalog
In the meantime, as a fail-safe treasury, the vault houses millions of specimens of over four thousand different species. The second doomsday effort lives on the campus of Nottingham University, in the Frozen Ark, which stores the DNA of 48,000 individuals from 5,438 different animal species. It’s Noah’s Ark moored in Robin Hood’s backyard, and its logo is a blue sketch of an ark sailing on a double helix of ocean waves. FOR LOVE OF A SNAIL Bryan loved snails, though not all snails equally. He was especially fascinated by one turban-shaped gastropod in the genus Partula. Among partulas, he had a thing for the species Partula mooreana. Just like Darwin’s finches, drifting colonies of partulas on tiny islands became cut off from their neighbors and rapidly diversified to a surprising degree in color, size, and shell motifs.
But I like knowing that the farther back one traces any lineage the narrower the path grows, to the haunt of just a few shaggy ancestors, with luck on their side, little gizmos in their cells, and a future storied with impulses and choices that will ultimately define them. The noble goal of the Human Genome Project is to use such knowledge to find new ways to understand, treat, and cure illness. In that sense, it’s a group portrait of us as a species, realized at last, a mere fifty years after Crick, Watson, and Franklin decoded the double-helix design of DNA. The only thing more unlikely than DNA itself, nature’s blueprint for building a human being, is our ability to decode it. Thus far, it’s our greatest voyage of discovery, and we’re still scouting its spiral coves. IN NORRBOTTEN, THE northernmost province of Sweden, the reindeer outnumber humans, and shimmery green veils of northern lights spiral up from the horizon like enchanted scarves.
An Optimist's Tour of the Future by Mark Stevenson
23andMe, Albert Einstein, Andy Kessler, augmented reality, bank run, carbon footprint, carbon-based life, clean water, computer age, decarbonisation, double helix, Douglas Hofstadter, Elon Musk, flex fuel, Gödel, Escher, Bach, Hans Rosling, Intergovernmental Panel on Climate Change (IPCC), Internet of things, invention of agriculture, Isaac Newton, Jeff Bezos, Kevin Kelly, Law of Accelerating Returns, Leonard Kleinrock, life extension, Louis Pasteur, low earth orbit, mutually assured destruction, Naomi Klein, off grid, packet switching, peak oil, pre–internet, Ray Kurzweil, Richard Feynman, Rodney Brooks, self-driving car, Silicon Valley, smart cities, social intelligence, stem cell, Stephen Hawking, Steven Pinker, Stewart Brand, strong AI, the scientific method, Wall-E, X Prize
If you add two long poles of sugar and salt for each line of molecular lovers to anchor themselves to (and so stand firm in their embraces) and give the whole shebang a twist, you’ll end up with something that looks like a spiralling ladder, its rungs made of adenine molecules holding on to thymine molecules and guanine molecules holding on to cytosine molecules, like billions of trapeze artists frozen in mid-clasp. There you are, then. The famous ‘double helix.’ The most famous molecule in the world. A cell’s individual hard drive. The code of life. A constantly referred-to book of recipes found in nearly every single cell that, amazingly, includes instructions to make everything in every cell. Your genome, encoded in the fêted and misunderstood ‘Deoxyribonucleic acid’ – the bane of unwitting criminals who leave it behind at crime scenes, the premise for Jurassic Park.
INDEX 23andMe 274, 297–9 42 100, 273 2001: A Space Odyssey 76, 102, 133 A Abengoa Solar 193 activated carbon 216–17 adenine 37–9, 46 aerosols 168–70 af Ekenstam, Robin 103, 104 Africa 252, 253, 302 Age of Spiritual Machines, The (Kurzweil) 274–5 agriculture 221–40, 253 Agüera y Arcas, Blaise 163 AInimals 92, 94, 96, 102–4, 105 algae 187, 210–12 Algenol Biofuels 187, 189 alleles 45, 48 Allen 83, 84 Amundsen, Roald 178 Anderson, Chris 291–5 Andrews, Lori 27 Angier, Natalie 47 Annas, George 27 Ansari X Prize for Spaceflight 135 Aquaflow Bionomic Corporation 208, 210–12 Arcadia 237–8 Arcadia (Stoppard) 281 Archer, David 177 Archon X Prize 50, 51 Aristotle 97 ARPANET 152 Art of War, The (Sun Tzu) 40–1, 51–2 artificial intelligence 73–107 Artificial Intelligence: AI 75 Asimov, Isaac 76–7 augmented reality 162–4 Augustine Commission 136 Australia climate change scepticism 168, 171 farming 221–40 Internet 157 mousepox virus 63–4 autocatalysis 270 B Bacillus subtilis 100, 273 Bacon, Francis 96–8, 99 bacteria 56–7, 61, 302 Bedau, Mark 66, 280 Bedford, James 15 Berners-Lee, Mike 169–70 Berners-Lee, Tim 154, 159 ‘Better World Shopper’ 163 Bezos, Jeff 141 BigDog 84 Bigelow, Robert 137 Billen, Abigail 31 Binney, Don 218 biochar 208–10, 212–20 biofuels 56–7, 61, 186–9, 210–12 biomass 209–10 bionics 14, 29, 301 biotechnology 35–70 bioterrorism 63–6, 68 BioTime 53–4 Birchall, Martin 20 bird flu 69–70 black carbon 169–70 Black Phantom 212–14, 219, 299, 301 Blackburn, Elizabeth 18 Blackstone Ranch 234 Blackwell, Paul 213 Blasco, Maria 18, 19 Blayney 235–7 Blenheim 210–12 blood transfusion 33 Blue Brain 90, 91 Blue Origin 141 Blundell, James 33 Bonaparte, Napoleon 146 Bongard, Josh 95 Boree Creek 237–8 Borman, Frank 135 Boston Dynamics 74–5 Bostrom, Nick 13, 17, 18, 22–31, 62, 65, 66 carbon-chauvinism 102 existential risk 63 and Kurzweil 267, 269 Bourke, Joanna 149 Brand, Stewart 108–9, 128, 270, 276 Branson, Richard 135, 141 Breazeal, Cynthia 76–82, 84–6, 90–2, 94, 101–2, 269, 277–8 Bréon, François-Marie 169 Brin, Sergey 273–4, 297 Broad Institute 40 Broecker, Wallace 173, 174, 177–86 Brooks, Rodney 76, 82, 83–4, 89, 103, 104, 105 Brown, John Seely 156, 282–3, 284–91, 292, 304 Buck, Vicki 207–8, 210–20, 288, 299 Burke, James 160, 161, 162 Burma 157 C C-3PO 76, 83, 102 cadmium 195, 196 California NanoSystems Institute 118 cancer 19, 40–1, 46–7 Candide (Voltaire) 218 carbon cycle 209 carbon dioxide (CO2) 57, 167–8, 170–1, 175–7, 186, 302 and agriculture 228–31, 233–5 biochar 209–10 biofuels 187–9 industrial uses 183–4 carbon nanotubes 110–11 carbon neutrality 243–4, 245 carbon scrubbers 179–85, 259–60, 299 Carbonscape 208, 212–20, 299, 301 carrying capacity 128–9 Castillo, Claudia 19–20, 33 Çatağay, Tolga 273 Catholic Church 106 Cave, Nick 304 Celera Genomics 36 Celsias 208 Cerf, Vint 151–64, 187, 245, 268, 283, 284, 299 Chappe, Abraham 146 Chappe, Claude 146 Chappe, René 146 charcoal 208–10, 212–20 chess 82, 83, 86 China 157, 200 Chomsky, Noam 303 chromosomes 44, 45–6 Chu, John 155 Chui, Alex 15 Church, George biofuels 57, 211 bioterrorism 63, 65–6 genome engineering 52, 56, 60–3, 64, 70, 105, 186–7, 203 genome sequencing 50–1 human genome project 35 human machines 89 IVF 106 and Lackner, Klaus 189 licensing 66–7 Personal Genome Project 36–7, 39, 41–50, 273, 299, 300, 301 Ćirković, Milan 65 cities 250, 252–3 Claramunt, Xavier 137 climate change 143, 164, 167–72, 174–7, 208 and agriculture 228–31, 233–5 Maldives 241–9, 256–62 Northwest Passage 178 Clinton, Bill 35–6 clouds 169 Cobar 231–5 Collins, Mike 135 Collins, Paul 192 Columbia University Medical Center 31 Columbus, Christopher 303 Comer, Gary 177, 178 Commercial Spaceflight Federation 138 Complete Genomics 51 Connections 160 Consortium for Polynucleotide Synthesis 68 Copenhagen Accord 256 Cornell University 93–6, 98–101, 210 couchsurfing.org 158 Coughlan, Anna 221–2, 239–40 Coughlan, Michael 221–2, 239–40 ‘Couldn’t Be Done’ (Tim Finn) 208 Crichton, Michael 122 cryonics 15–16 Cuba 157 cytosine 37–9, 46 D dance 155 De Cari, Gioia 262 de Grey, Aubrey 14, 16, 17–18, 21, 34 ‘Death Clock’ 12–13 deductive reason 97 Deep Blue 82–3 del Cardayré, Stephen 61 Desertec Industrial Initiative 193 Deutsche Bank 193 diatoms 117–18 diesel 56–7 Dijkstra, Edsger 82 DNA (Deoxyribonucleic acid) 38–9, 40, 297–8 naked 46 nanotechnology 113, 119–20 Parkinson’s disease 273–4 Door into Summer (Heinlein) 142 double helix 38 double pendulum 98–9 Dragon 136 Drexler, Eric 109–17, 125, 127–30, 286, 287, 299, 300 critics 123–4 Grey Goo 121–3 and Kurzweil 268, 269 E E. coli 56–7, 61, 64 E85 cars 188 EasyJet 20 education 284–5, 288 Egypt 157 Ehrenreich, Barbara 303 Eigler, Donald 113, 125 Einhorn, Thomas 31 Einstein, Albert 140 Eisenberger, Peter 184 electricity 285–6 Eliza 86–7 Ember, Carol 147 enhancement 26–9 Endy, Drew 66 energy 191–2, 193–5, 202, 204 fossil fuels 168, 191–2, 193, 302 solar 190–1, 192–3, 195–205, 206, 274, 295, 302 Engines of Creation (Drexler) 109, 110–11, 115, 121, 122, 123, 127–8, 300 Enlightenment 267 Enriquez, Juan 33, 278–82, 293 Eros (Asteroid) 134 Estep, Preston 16 ethanol 187 Ethiopia 199, 200 Etiwanda Station 231–5 Eureqa 101 evolution 70, 105, 279–80, 281–2 existential risk 63 Exxon Mobil 56 EZ-Rocket 142 F Falcon 9 136 farming 221–40, 253 Feynman, Richard 112, 113 Finn, Tim 208 Flannery, Tim 215 flu 64–5, 69–70 Følling’s disease 44, 58 foot-and-mouth disease 68–9 forests 253–4 Forster, E.
Atlas Obscura: An Explorer's Guide to the World's Hidden Wonders by Joshua Foer, Dylan Thuras, Ella Morton
anti-communist, Berlin Wall, British Empire, Buckminster Fuller, centre right, Charles Lindbergh, colonial rule, Colonization of Mars, cosmic microwave background, cuban missile crisis, dark matter, double helix, East Village, Exxon Valdez, Fall of the Berlin Wall, Frank Gehry, germ theory of disease, Golden Gate Park, Google Earth, Haight Ashbury, horn antenna, Ignaz Semmelweis: hand washing, index card, Jacques de Vaucanson, Kowloon Walled City, Louis Pasteur, low cost airline, Mahatma Gandhi, mass immigration, mutually assured destruction, Panopticon Jeremy Bentham, phenotype, Pluto: dwarf planet, Ronald Reagan, Rubik’s Cube, Sapir-Whorf hypothesis, Search for Extraterrestrial Intelligence, trade route, transatlantic slave trade, transcontinental railway, Tunguska event, urban sprawl, Vesna Vulović, white picket fence, wikimedia commons, working poor
The bridge is on the grounds of a 19th-century estate about 30 minutes west of Glasgow. 55.942506 4.521874 Garden of Cosmic Speculation HOLYWOOD, DUMFRIES AND GALLOWAY Among the daffodils and daisies of the Garden of Cosmic Speculation are black holes, Fibonacci sequences, fractals, and DNA double helixes. Architectural theorist Charles Jencks and his late wife, Maggie Keswick, designed the 30-acre garden for their own property. Its aesthetic is guided by the fundamentals of modern physics, reflecting the shapes and patterns of the unfolding universe. Begun in 1988, the garden took almost 20 years to build, during which time Keswick succumbed to cancer. Jencks continued the project in her memory, occasionally altering designs in response to shifts and breakthroughs in scientific knowledge. (The Human Genome Project inspired the DNA Garden section, with its plant-threaded double helix.) Holywood, 5 miles (8 km) north of Dumfries. The garden is open to the public one day a year, during the first week of May.
Within a few months he had crafted an inspiring feat of engineering, a spiral staircase with no visible supports and no central column. When the nuns went looking for the benevolent stranger to pay him and thank him, he had disappeared. They concluded that the miracle staircase was built by St. Joseph himself. The fact that there are 33 steps—equaling the number of years Jesus lived—only adds to the legend. The spiral stairs are structurally sound but a little bouncy owing to their springlike double helix shape. They have been closed to public foot traffic since the 1970s, but if you book your wedding in the chapel you can stand on them to get your photo taken. 207 Old Santa Fe Trail, Santa Fe. 35.685387 105.937637 The spiral staircase is said to have been constructed with the help of divine intervention. Also in New Mexico American International Rattlesnake Museum Albuquerque · Glass cages of tail-shaking serpents line the walls of this museum, which is dedicated to showing the gentler, softer underbelly of the often-feared rattlesnake. 109 East Palace Santa Fe · This innocuous-looking storefront was once the secret jump-off spot for Manhattan Project scientists working on the development of the atomic bomb.
Information: A Very Short Introduction by Luciano Floridi
agricultural Revolution, Albert Einstein, bioinformatics, carbon footprint, Claude Shannon: information theory, conceptual framework, double helix, Douglas Engelbart, Douglas Engelbart, George Akerlof, Gordon Gekko, industrial robot, information asymmetry, intangible asset, Internet of things, invention of writing, John Nash: game theory, John von Neumann, Laplace demon, moral hazard, Nash equilibrium, Nelson Mandela, Norbert Wiener, Pareto efficiency, phenotype, Pierre-Simon Laplace, prisoner's dilemma, RAND corporation, RFID, Thomas Bayes, Turing machine, Vilfredo Pareto
But it was only in the 19th century that Gregor Mendel (1822-1884), the founder of genetics, showed that phenotypes are passed on, from one generation to the next, through what were later called genes. In 1944, in a brilliant book based on a series of lectures, entitled What Is Life?, the physics Nobel laureate Erwin Schrodinger (1887-1961) outlined the idea of how genetic information might be stored. He explicitly drew a comparison with the Morse alphabet. In 1953, James Watson (born 1928) and Francis Crick (1916-2004) published their molecular model for the structure of DNA, the famous double helix, one of the icons of contemporary science. Crick explicitly acknowledged his intellectual debt to Schrodinger's model. In 1962, Watson, Crick, and Maurice Wilkins (1916-2004) were jointly awarded the Nobel Prize for Physiology or Medicine `for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material'. Information had become one of the foundational ideas of genetics.
This Is How You Lose the Time War by Amal El-Mohtar, Max Gladstone
What would Genghis say if we built a bridge together, Red? Suppose we reached across the burn of threads and tangles, cut through the braid’s knots—suppose that we defected, not to each other’s sides, but to each other? We’re the best there is at what we do. Shall we do something we’ve never done? Shall we prick and twist and play the braid until it yields us a place downthread, bend the fork of our Shifts into a double helix around our base pair? Shall we build a bridge between our Shifts and hold it—a space in which to be neighbours, to keep dogs, share tea? It’ll be a long, slow game. They’ll hunt us fiercer than they ever hunted each other—but somehow I don’t think you’ll mind. I’ve bought you five minutes to bust out. Instructions on overleaf, though I doubt you’ll need them. I don’t give a shit who wins this war, Garden or the Agency—towards whose Shift the arc of the universe bends.
The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--And How We Can Get There by Vincent T. Devita, Jr., M. D., Elizabeth Devita-Raeburn
I decided to write this book because I felt that the taxpayers who funded the war on cancer should know how their money was spent and that people with cancer and their families should know what is available for them—and how to make sure they get it. I want to lift the scrim that separates the public from those who study this disease and the individuals and institutions that treat it. What you will see behind the scenes is not always flattering. The process of science is inextricable from human nature. As James Watson wisely said, in the preface to his autobiographical book about discovering the structure of DNA, The Double Helix, “Science seldom proceeds in the straightforward logical manner imagined by outsiders. Instead, its steps forward (and sometimes backward) are often very human events in which personalities and cultural traditions play major roles.” It’s true. It will always be true. Watson’s book illustrates it in the search for the structure of DNA. In this book, I show you how it unfolded within the context of the war on cancer.
Most of the NCAB fell for it. Schmidt didn’t. And he didn’t just express his concern; he coolly and justifiably destroyed the logic that was presented. The program was stopped, and the director was perpetually terrified of him thereafter. You didn’t present garbage to Schmidt and expect it to go unnoticed. He exuded confidence and was fearless in dealing with unruly, arrogant board members. Jim Watson, of double helix fame, had been appointed to the NCAB because he was a brilliant scientist. But he also hated the concept of the war on cancer and was purposefully rude at board meetings to show his contempt. The board chair couldn’t control him. Watson was, after all, a Nobel laureate. He liked to lean back and put his feet up on the table and read The New York Times, lowering the paper only to interject a derogatory comment here and there.
Human Diversity: The Biology of Gender, Race, and Class by Charles Murray
23andMe, affirmative action, Albert Einstein, Alfred Russel Wallace, Asperger Syndrome, assortative mating, basic income, bioinformatics, Cass Sunstein, correlation coefficient, Daniel Kahneman / Amos Tversky, double helix, Drosophila, epigenetics, equal pay for equal work, European colonialism, feminist movement, glass ceiling, Gunnar Myrdal, income inequality, Kenneth Arrow, labor-force participation, longitudinal study, meta analysis, meta-analysis, out of africa, p-value, phenotype, publication bias, quantitative hedge fund, randomized controlled trial, replication crisis, Richard Thaler, risk tolerance, school vouchers, Scientific racism, selective serotonin reuptake inhibitor (SSRI), Silicon Valley, social intelligence, statistical model, Steven Pinker, The Bell Curve by Richard Herrnstein and Charles Murray, the scientific method, The Wealth of Nations by Adam Smith, theory of mind, Thomas Kuhn: the structure of scientific revolutions, twin studies, universal basic income, working-age population
That’s why I adopt contemporary practice in the technical literature, which uses ancestral population or simply population instead of race or ethnicity, throughout the rest of Part II. Third Interlude: Genetic Terms You Need to Know to Read the Rest of the Book I cannot discuss any of the propositions of Part II without using technical terms regarding genetics. Hence it’s time for another interlude, a refresher course in this area of biology. Genome. A genome consists of two strands of DNA (deoxyribonucleic acid), intertwined in the famous double helix and found in the nucleus of almost every cell of every organism. In humans, each strand of DNA consists of a string of more than three billion occurrences of one of four chemicals: adenine, thymine, guanine, and cytosine, usually referred to by their first letters, A, T, G, or C. Each occurrence in each strand is lightly linked by hydrogen bonds to a corresponding occurrence in the other strand.
From Darwin’s Insights to the Modern Synthesis The word genetics wasn’t even coined until 1905, soon after Gregor Mendel’s pioneering work was rediscovered after having been ignored for almost half a century. The first half of the twentieth century saw a series of landmark discoveries about the biology of genetic transmission, led by Thomas Hunt Morgan in the early decades and culminating in the discovery of the double-helix structure of DNA by James Watson and Francis Crick in 1953.17 From the beginning, scientists were aware of the potential importance of genetics for explaining how evolution worked at the molecular level. One of the earliest theoretical findings was genetics’ equivalent to Newton’s first law of motion: identification of the circumstances under which the frequencies of alleles at a given site would remain stable.18 Discovered independently by Godfrey Hardy and Wilhelm Weinberg, who both published in 1908, it became known as the Hardy-Weinberg equilibrium.
Rather than having a set genetic blueprint, epigenetics demonstrates that although our genes themselves are fixed, our genetic expression, much of which is heritable, is also interconnected with a wide range of environmental factors.60 With rare exceptions, the mainstream media’s reporting on the science behind epigenetics bears little resemblance to what’s actually been discovered. The Basics Your personal double helix of DNA resides in the nucleus of a cell. The rest of the cell contains the proteins that enable it to perform its particular function, whether it be a cell in a biceps or the brain. For a cell to do that, somehow the small number of relevant genes in the DNA producing those proteins for that cell type must be identified and their information transcribed. Then the transcription must be transferred to the ribosome, the place in the cell where proteins are synthesized.
Warnings by Richard A. Clarke
active measures, Albert Einstein, algorithmic trading, anti-communist, artificial general intelligence, Asilomar, Asilomar Conference on Recombinant DNA, Bernie Madoff, cognitive bias, collateralized debt obligation, complexity theory, corporate governance, cuban missile crisis, data acquisition, discovery of penicillin, double helix, Elon Musk, failed state, financial thriller, fixed income, Flash crash, forensic accounting, friendly AI, Intergovernmental Panel on Climate Change (IPCC), Internet of things, James Watt: steam engine, Jeff Bezos, John Maynard Keynes: Economic Possibilities for our Grandchildren, knowledge worker, Maui Hawaii, megacity, Mikhail Gorbachev, money market fund, mouse model, Nate Silver, new economy, Nicholas Carr, nuclear winter, pattern recognition, personalized medicine, phenotype, Ponzi scheme, Ray Kurzweil, Richard Feynman, Richard Feynman: Challenger O-ring, risk tolerance, Ronald Reagan, Sam Altman, Search for Extraterrestrial Intelligence, self-driving car, Silicon Valley, smart grid, statistical model, Stephen Hawking, Stuxnet, technological singularity, The Future of Employment, the scientific method, The Signal and the Noise by Nate Silver, Tunguska event, uranium enrichment, Vernor Vinge, Watson beat the top human players on Jeopardy!, women in the workforce, Y2K
From rain-forest mushrooms to tide-pool seashells, that fascination continues to drive her career to this day. “My dad loved books, and he loved reading about science,” she told us when we sat down in her office at UC Berkeley, where she is a professor of biology and manages a huge laboratory. “He would buy books and throw them on my bed. Early on, I was probably in about sixth grade or so, one of them was The Double Helix. I remember reading it and being just stunned that scientists could devise experiments to figure out something like the structure of DNA. It was just mind-blowing to me as a kid.”1 From then on, it wasn’t enough to just observe nature. “I wanted to know the chemicals that were in there; what’s the difference in the DNA that made, for example, one mushroom different from another?” Professor Doudna laughed, recalling the memory, and it was clear that the spark of scientific wonder, first realized in those early years, remains just as strong today.
First, at Pomona College, she worked in the lab of Sharon Panasenko, her undergraduate advisor, whom Doudna credits as a strong female role model in science. She later completed her Ph.D. at Harvard under Jack Szostak, who went on to share the 2009 Nobel Prize for his work in genetics. There Doudna developed a fascination for RNA, the close relative to its more famous genetic cousin, DNA. DNA, as is taught in any high school biology class, is the molecule that carries the hereditary information of all living organisms. Its famous double-helix structure looks like a long spiral staircase, twisting around itself, the steps holding the encoded information in what are called base pairs. The order of those base pairs is what’s important; it’s a blueprint for our design, regulating the creation and functions of all our cells and making life as we know it possible. While Doudna was at Harvard, RNA was widely believed to be DNA’s secretary: RNA carried out the commands spelled out by DNA.
The Future of Technology by Tom Standage
air freight, barriers to entry, business process, business process outsourcing, call centre, Clayton Christensen, computer vision, connected car, corporate governance, creative destruction, disintermediation, disruptive innovation, distributed generation, double helix, experimental economics, full employment, hydrogen economy, industrial robot, informal economy, information asymmetry, interchangeable parts, job satisfaction, labour market flexibility, Marc Andreessen, market design, Menlo Park, millennium bug, moral hazard, natural language processing, Network effects, new economy, Nicholas Carr, optical character recognition, railway mania, rent-seeking, RFID, Silicon Valley, Silicon Valley ideology, Silicon Valley startup, six sigma, Skype, smart grid, software as a service, spectrum auction, speech recognition, stem cell, Steve Ballmer, technology bubble, telemarketer, transcontinental railway, Y2K
This page intentionally left blank 8 CLIMBING THE HELICAL STAIRCASE THE FUTURE OF TECHNOLOGY Climbing the helical staircase Biotechnology has its troubles, but in the long term it may change the world t has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” With these ironic words, James Watson and Francis Crick began a biological revolution. Their paper on the structure of dna, published in Nature in April 1953, described the nowfamous double helix. It showed that the strands of the helix complement each other. It inferred, correctly, that either strand of the helix could thus act as a template for the other, allowing the molecule to replicate itself. And it suggested that because the four types of nucleotide sub-unit of which each strand is composed can be arranged in any order, a single strand could act as a message tape telling a cell which proteins to make, and therefore what job to do.
Fire x-rays through such a crystal and they will interact with the atoms in that crystal. The pattern that emerges will, with enough maths (nowadays done by computer), tell you how the atoms in the crystal are arranged. This works with any crystal, not just one made of protein. Indeed, it was the photographs taken by Rosalind Franklin of the x-ray patterns produced by dna crystals that gave James Watson and Francis Crick the clue they needed to understand that dna is a double helix. x-ray crystallography has already generated several drugs. Viracept, devised by Agouron (now part of Pfizer) and Agenerase, developed by Vertex of Cambridge, Massachusetts, are anti-aids drugs that inhibit a protein called hiv-protease. Relenza, devised by Biota Holdings, of Melbourne, Australia, gums up an influenza protein. Until recently, however, x-raying crystals has been a bespoke craft.
The Code of Capital: How the Law Creates Wealth and Inequality by Katharina Pistor
"Robert Solow", Andrei Shleifer, Asian financial crisis, asset-backed security, barriers to entry, Bernie Madoff, bilateral investment treaty, bitcoin, blockchain, Bretton Woods, business cycle, business process, Capital in the Twenty-First Century by Thomas Piketty, Carmen Reinhart, central bank independence, collateralized debt obligation, colonial rule, conceptual framework, Corn Laws, corporate governance, creative destruction, Credit Default Swap, credit default swaps / collateralized debt obligations, cryptocurrency, Donald Trump, double helix, Edward Glaeser, Ethereum, ethereum blockchain, facts on the ground, financial innovation, financial intermediation, fixed income, Francis Fukuyama: the end of history, full employment, global reserve currency, Hernando de Soto, income inequality, intangible asset, investor state dispute settlement, invisible hand, joint-stock company, joint-stock limited liability company, Joseph Schumpeter, Kenneth Rogoff, land reform, land tenure, London Interbank Offered Rate, Long Term Capital Management, means of production, money market fund, moral hazard, offshore financial centre, phenotype, Ponzi scheme, price mechanism, price stability, profit maximization, railway mania, regulatory arbitrage, reserve currency, Ronald Coase, Satoshi Nakamoto, secular stagnation, self-driving car, shareholder value, Silicon Valley, smart contracts, software patent, sovereign wealth fund, The Nature of the Firm, The Wealth of Nations by Adam Smith, Thorstein Veblen, time value of money, too big to fail, trade route, transaction costs, Wolfgang Streeck
The genetic foundation of life was discovered only in the nineteenth century by the friar and botanist Gregor Mendel. By 1944, scientists had discovered that DNA (deoxyribonucleic acid) was the carrier for genetic information, and in 1953, James Watson and Francis Crick published a paper in which they depicted the double helix structure of the DNA.1 Their work marked a major breakthrough 108 e n c Los i n g n at U r e ’ s co d e 109 that revolutionized our understanding of biology, inheritance, and evolution and earned the two scientists, together with Maurice Wilkins, the Nobel Prize in Medicine in 1962. Genetic research has made huge strides ever since. Fifty years after the publication of the double helix, the Human Genome Project completed a map of the entire gene sequence for homo sapiens, giving us “the ability, for the first time, to read nature’s complete genetic blueprint for building a human being.”2 The race to convert this knowledge into wealth-producing assets did not wait until the full sequence was known.
Red Mars by Kim Stanley Robinson
“Well, the cable’s pretty much unbreakable,” Steve replied. “You broke the cable?” Yeli exclaimed. “Well, no, we separated the cable from Clarke, is what we did. But the effect is the same. That cable is on its way down.” The group cheered again, somewhat more weakly. Steve explained to the travelers over the noise, “The cable itself was pretty much impervious, it’s graphite whisker with a diamond sponge-mesh gel double-helixed into it, and they’ve got smart pebble defense stations every hundred kilometers, and security on the cars that was intense. So Arkady suggested we work on Clarke itself. See, the cable goes right through the rock to the factories in the interior, and the actual end of it was physically as well as magnetically bonded to the rock of the asteroid. But we landed with a bunch of our robots in a shipment of stuff from orbit, and dug into the interior and placed thermal bombs outside the cable casing, and around the magnetic generator.
The impact zone was never anything but a moving white blob, like a flaw in the tape; no video was capable of registering such illumination. But as the montage continued the images had been slowed down and processed in every way possible, and one of these processed images was the final clip, an ultra-slow motion shot in which one could see details that would have been impossible to spot live. And so they could see that as the line had crossed the sky, the burning graphite had stripped away first, leaving an incandescent double helix of diamond, flowing majestically out of a sunset sky. All a gravestone, of course, the people on it already dead at that point, burned away; but it was hard to think of them when the image was so utterly strange and beautiful, a vision of some kind of fantasy DNA, DNA from a macroworld made of pure light, plowing into our universe to germinate a barren planet. . . . Nadia stopped watching the TV, moved into the copilot’s seat to help spot the other plane.
Clouds of smoke were surging up into the predawn sky over west Tharsis, pouring so high that they got up out of the shadow of the planet and were lit by the rising sun; they were mushroom clouds, their heads a bright pale pink, their dark gray stalks illuminated by reflection from above. Slowly the sunlight moved down the tumultuous stalks, until they were all burnished by the new morning sun. Then the lofty line of yellow and pink mushroom clouds drifted across a sky that was a delicate shade of indigo pastel: it looked like a Maxfield Parrish nightmare, too strange and beautiful a sight to believe. Nadia thought of the cable’s last moment, that image of the incandescent double helix of diamonds. How was it that destruction could be so beautiful? Was there something in the scale of it? Was there some shadow in people, lusting for it? Or was it just a coincidental combination of the elements, the final proof that beauty has no moral dimension? She stared and stared at the image, focused all her will on it; but she could not make it make sense. “That may be enough particulate matter to trigger another global dust storm,” Sax observed.
Genius: The Life and Science of Richard Feynman by James Gleick
Albert Einstein, American ideology, Arthur Eddington, Brownian motion, double helix, Douglas Hofstadter, Ernest Rutherford, gravity well, Gödel, Escher, Bach, Isaac Newton, John von Neumann, Menlo Park, Murray Gell-Mann, mutually assured destruction, Norbert Wiener, Norman Mailer, pattern recognition, Pepto Bismol, Richard Feynman, Richard Feynman: Challenger O-ring, Ronald Reagan, Rubik’s Cube, Sand Hill Road, Schrödinger's Cat, sexual politics, Stephen Hawking, Steven Levy, the scientific method, Thomas Kuhn: the structure of scientific revolutions, uranium enrichment
Goodstein thought he seemed depressed and worried. When Goodstein came down to breakfast at the faculty club, he found Feynman already there, talking with someone who Goodstein gradually realized was the codiscoverer of DNA, James Watson. Watson gave Feynman a manuscript tentatively titled Honest Jim. It was a tame memoir by later standards, but when it was published—under a different title, The Double Helix—it caused an enormous popular stir. With a candor that shocked many of Watson’s colleagues, it portrayed the ambition, the competitiveness, the blunders, the miscommunications, and the raw excitement of real scientists. Feynman read it in his room at the Chicago faculty club, skipping the cocktail party in his honor, and found himself moved. Later he wrote Watson: Don’t let anybody criticize that book who hasn’t read it through to the end.
New York: Scribner. Underwood, E. Ashworth. 1937. Manual of Tuberculosis for Nurses and Public Health Workers. Second edition. Edinburgh: E. & S. Livingstone. Von Neumann, John. 1955. Mathematical Foundations of Quantum Mechanics. Princeton: Princeton University Press. Waksman, Selman A. 1964. The Conquest of Tuberculosis. Berkeley: University of California Press. Watson, James D. 1968. The Double Helix. New York: Atheneum. Weart, Spencer R. 1988. Nuclear Fear: A History of Images. Cambridge, Mass.: Harvard University Press. Weaver, Jefferson Hane, ed. 1987. The World of Physics. 3 volumes. New York: Simon and Schuster. Weinberg, Steven. 1977a. “The Search for Unity: Notes for a History of Quantum Field Theory.” Daedalus 106:17. ——. 1977b. The First Three Minutes: A Modern View of the Origin of the Universe.
., 192 n Coleman, Sidney, 10 n, 323–24, 389, 405 color (light), 130, 131, 321, 357, 362 color (particle property), 229, 387, 390, 402–3, 432 Columbia Grammar and Preparatory School (New York), 307, 309 Columbia University, 49, 144, 180, 252, 267, 309, 334, 337, 384 Rabi at, 53, 91, 232, 234 Schwinger at, 215–16 Commerce, Department of, United States, 296 complementarity, 40, 54 Compton, Karl, 55, 94, 138 computing, 6, 175–82, 329, 348, 354–55, 435 analog, 137 ENIAC, 182 Condon, Edward, 54–55 consciousness, 68–69, 123–24, 243, 321, 431 continental drift, 321 Cook, Richard, 423–24 Coolidge, Albert Sprague, 85 Cooper, Leon, 303 Copyright Office, United States, 328 Coriolis force, 37 Cornell University, 3, 53, 123 Bethe at, 53, 80, 166, 225–27, 238, 277 Dyson at, 7, 238–39 Feynman at, 10, 204, 214–22, 225–27, 263, 277–78, 286, 288, 293–94, 365 postwar growth, 210–12, 221 women at, 212 cosmic rays, 81–82, 98, 114, 168, 215, 253, 304, 332 cosmology, 112–14, 123–26, 293, 353–54 Crease, Robert, 433–34 n Crick, Francis, 349, 351, 382 current algebra, 328, 338, 393 Cutler, Monarch, 82–83 Cvitanović, Predrag, 279–80 n cyclotron, 95–96, 107–8, 136, 160, 210–11, 305–6 Daghlian, Harry, 196 Darwin, Charles, 207 Dawes, Rufus C, 41 Day, Edmund Ezra, 210 Delbrück, Max, 293, 340, 349 Depression, 41, 46, 53, 55, 77, 281, 308 Descartes, René, 58–59, 67–68 diffusion, 79, 80, 171–75, 182, 249 and entropy, 119 in uranium separation, 139–40, 144 DiMaggio, Joe, 328 Dirac, Paul Adrien Maurice antimatter, 122, 253 at Cambridge, 53–54, 166, 236 Feynman and, 7, 184, 226, 228–29, 437 as genius, 43–44, 322 history of quantum mechanics, 72–73 Lagrangian in quantum mechanics, 128–29, 131–32, 226 parity and, 334 at Pocono, 5, 7, 255–58 The Principles of Quantum Mechanics, 56, 76, 99–100, 260 religion and, 58 renormalization and, 347–49 Schwinger and, 48–49 Slater and, 53–54 Dirac equation, 5, 73, 229–30, 234, 261–62, 336–38 discovery, 284, 313–14, 321 individual vs. multiple, 329 myths of, 279, 315, 380 DNA, 14, 293, 349–351, 355, 386 Dr. Strangelove (Kubrick), 156 Don Juan, 319 Double Helix, The (Watson), 386 DuBridge, Lee, 295, 415 Duff, William, 313 Dyson, Freeman J., 298 background, 235–38 at Cornell, 235, 238 Feynman and, 3–4, 7, 240–41, 244, 249–51, 262–66, 273, 323, 368, 424 genius and, 317, 320–21, 323, 328 Nobel Prize, 377–78 Oppenheimer and, 269–70 quantum electrodynamics, 239–40, 252, 259, 263, 266–72, 274, 279–80, 307, 309, 348, 367 Schwinger and, 261, 266–68, 271 Dyson, George, 235, 267 Dyson, Mildred, 235–36 Dyson graph, 269, 273 earthquake science, 281–82 Eastman, George, 55 Eddington, Arthur, 52, 75, 109, 433 Edgerton, Harold, 77 Edison, Thomas Alva, 40–44, 54–55, 319–20, 329 Einstein, Albert, 5, 9–10, 45, 54, 56, 70, 112, 120, 123, 129, 209, 244, 264, 281, 324, 386, 433–34 atomic bomb, 136 Bohr and, 40 brain, 311–12 ether, 18, 101–2 Feynman and, 98, 115, 117, 118–19, 257 legend, 41–44, 311–13, 320–22, 326 Nobel Prize, 375–77 photoelectric effect, 71, 377 on Princeton, 97 on quantum mechanics, 40, 45, 215, 243, 347 relativity, 42–43, 71, 72, 255, 329, 351–52, 365, 368, 375, 429–30 religion and, 58, 372 retirement, 118–19 Einstein Award, 295–96, 343, 378–79 Eisenhower, Dwight D., 296, 297, 340 electric light, 319, 329 electricity, 320 electron, 4, 5, 33, 71–73, 79, 86, 114, 122–23, 127, 231–32, 283, 306 -electron interaction, 48–49, 273 -neutron interaction, 270–71 -photon interaction, 241–42, 246 -positron interaction, 253–54 -proton interaction, 391–95 in beta decay, 335–37 magnetic moment, 251–52 reality of, 375 self-energy, 99–102, 109–12, 239–40, 251–52, 256, 273–75, 380 in solids, 88–90, 349 spin, 229–31, 239 two-slit experiment, 247–48, 250, 366 electron microscope, 38, 355 electroweak theory, 431 Encyclopaedia Britannica, 25, 38, 49, 286, 354–55 energy, 31, 38–39 conservation of, 60, 88, 139, 330, 360–61 force vs., 87–89, 226 gravity waves and, 352 infinite, 49, 99, 253 kinetic and potential, 60–61, 121 mass and, 4, 42 negative, 122, 253 quantum mechanics and, 71–72, 74, 127 textbooks and, 398 Engineering and Science, 355–56 ENIAC, 182 entropy, 355, 362–63, 435 Erhard, Werner, 405–6 Esalen Institute, 407 est Foundation, 405 ether, 18, 42, 48, 101 Ethical Culture School (New York), 24, 159 Euclid, 34, 41, 121 evolution, 31–32, 208, 332 exclusion principle, 6–7, 255, 258 explanation, 357, 364–75 Explorer satellites, 415–16 Far Rockaway (New York), 20–24, 45–49, 64, 98, 126, 191, 409 Temple Israel, 219, 296 Far Rockaway High School, 30–36, 60–61, 302 Young People’s Socialist League, 296 Faraday, Michael, 101 Faulkner, William, 380 Faust (Goethe), 52, 66, 208, 236 Federal Bureau of Investigation, 296–97 Fermat, Pierre de, 57–58, 61, 250 Fermat’s last theorem, 267 Fermi, Enrico, 305, 309 calculating ability, 175 death, 294 Feynman and, 282–83 as genius, 322 “lightness of approach,” 166–67 nuclear reactor, 146, 157, 161 nuclear research, 79, 95, 173 at Pocono, 5, 255–57 Schwinger and, 216 at Trinity, 155, 203 Fermi-Dirac statistics, 399 Fermi interaction, see weak interaction Feynman, Anne (paternal grandmother), 24 Feynman, Arline Greenbaum (first wife), 45–46, 64–65, 67, 69, 91, 116–17, 146, 184–88, 206, 212–14, 221–22, 264, 287, 289, 290, 343, 409–10 illness, 117, 126–27, 134–35, 149–51, 159–60, 170, 191–96, 200–202 marriage, 149–51 Feynman, Carl (son), 346, 378, 396–98, 405, 409, 435 Feynman, Gweneth Howarth (third wife), 340–47, 353, 378, 401–2, 405, 408, 426, 438 Feynman, Henry Phillips (brother), 25–26, 46, 221 Feynman, Joan (sister), 16, 19, 26–27, 30, 40–42, 46, 64, 135, 194–95, 202, 220–21, 335–36, 438 Feynman, Louis (paternal grandfather), 24 Feynman, Lucille (née Phillips, mother), 15, 19, 23, 24–26, 27–28, 32, 40–42, 46, 115, 149–51, 156, 159, 169, 182–83, 201, 213–14, 220–21, 263, 293, 346, 378–79, 397 Feynman, Mary Louise (second wife), see Bell, Mary Louise Feynman, Melville (father), 22, 24–26, 27–31, 40–42, 46, 68, 91, 126, 133, 149–51, 169, 176, 186, 214, 219–22, 242, 379, 388, 410 Feynman, Michelle (daughter), 346, 396–98, 401, 408, 437 Feynman, Richard Phillips “aggressive dopiness,” 405 ambition, 34, 170, 265–66 atomic bomb and, 3, 6, 11, 15, 140, 153–205, 213, 216, 218, 224–25, 263–64, 417 awards, 295–96, 343, 375–86 beaches and, 21–22, 283–87, 339, 401 beauty and, 13, 373, 435 birth, 25 books, 11–13 The Character of Physical Law, 13, 364–71 The Feynman Lectures on Physics, 12, 21–22, 37–38, 145, 357–64, 407, 435–36 Photon-Hadron Interactions, 395 QED: The Strange Theory of Light and Matter, 13 Quantum Electrodynamics, 12 Surely You’re Joking, Mr.
Cosmos by Carl Sagan
Albert Einstein, Alfred Russel Wallace, Arthur Eddington, clockwork universe, dematerialisation, double helix, Drosophila, Edmond Halley, Eratosthenes, Ernest Rutherford, germ theory of disease, global pandemic, invention of movable type, invention of the telescope, Isaac Newton, Johannes Kepler, Lao Tzu, Louis Pasteur, Magellanic Cloud, Mars Rover, Menlo Park, music of the spheres, pattern recognition, planetary scale, Search for Extraterrestrial Intelligence, spice trade, Thales and the olive presses, Thales of Miletus, Tunguska event
These are the best that four billion years of evolution could produce, containing the full complement of information on how to make a cell, a tree or a human work. The amount of information in human DNA, if written out in ordinary language, would occupy a hundred thick volumes. What is more, the DNA molecules know how to make, with only very rare exceptions, identical copies of themselves. They know extraordinarily much. DNA is a double helix, the two intertwined strands resembling a “spiral” staircase. It is the sequence or ordering of the nucleotides along either of the constituent strands that is the language of life. During reproduction, the helices separate, assisted by a special unwinding protein, each synthesizing an identical copy of the other from nucleotide building blocks floating about nearby in the viscous liquid of the cell nucleus.
The genetic material of the whale, like the genetic material of human beings, is made of nucleic acids, those extraordinary molecules capable of reproducing themselves from the chemical building blocks that surround them, and of turning hereditary information into action. For example, one whale enzyme, identical to one you have in every cell of your body, is called hexokinase, the first of more than two dozen enzyme-mediated steps required to convert a molecule of sugar obtained from the plankton in the whale’s diet into a little energy—perhaps a contribution to a single low-frequency note in the music of the whale. The information stored in the DNA double helix of a whale or a human or any other beast or vegetable on Earth is written in a language of four letters—the four different kinds of nucleotides, the molecular components that make up DNA. How many bits of information are contained in the hereditary material of various life forms? How many yes/no answers to the various biological questions are written in the language of life? A virus needs about 10,000 bits—roughly equivalent to the amount of information on this page.
Martians by Kim Stanley Robinson
She and Nirgal were actually a lot alike in that sense, it should have worked. But it didn't, and that poor boy wandered the world as lonely as old Coyote himself. And he didn't have Maya—or he did, but for him she replaced Hiroko, not Jackie. Not motherless but partnerless. I felt for him. You see couples who have grown together like two old trees making one plant, trunks intertwined like the double helix itself, and you think, Yes that's the way it's supposed to be. It wouldn't be so lonely then. But there you are. You can't make partners by wanting them. So it's back to friends, and loneliness. And so I watched Nirgal live his lives like a second self cast loose on the wind. We all live the same stories. Nirgal is like a brother to me. And Sax is my brother in wonder. In all truth, there isn't a purer soul in the world.
But the grass wouldn't be as green.” “You don't think so?” says the neighbor. Back inside to recover the list and check off mowing. Then he rushes to his desk ready to write. Immense concentration brought to bear instantaneously, or at least as soon as another cup of black mud hits the bloodstream. The first word for the day comes quickly: “The” Of course it might not be the right word. He considers it. Time passes in a double helix of eternal no-time, in the blessing that cannot be spoken. He revises, rewrites, restructures. The phrase grows, shrinks, grows, shrinks, changes color. He tries it as free verse, sestina, mathematical equation, glossolalia. Finally he returns to the original formulation, complexifying it with an added nuance: “The End” It says what needs to be said; and it's twice as many words as his usual daily output.
Infinity in the Palm of Your Hand: Fifty Wonders That Reveal an Extraordinary Universe by Marcus Chown
Albert Einstein, Anton Chekhov, Arthur Eddington, Carrington event, dark matter, Donald Trump, double helix, Edmond Halley, gravity well, horn antenna, Isaac Newton, Kickstarter, microbiome, Richard Feynman, Search for Extraterrestrial Intelligence, Solar eclipse in 1919, Stephen Hawking, Turing machine
Instead, in a bewilderingly complex way, genes are switched on and off by other genes and by concentrations of chemicals in the environment. It means that the human genome reads differently at different times in the development of an embryo—in effect making it appear like more than one set of 24,000 genes. 3. Adenine (A), guanine (G), cytosine (C), and thymine (T) are molecules known as “bases.” They form the backbone of the “double-helix” of the giant DNA molecule. Each group of three are the bases codes for a different amino acid—for instance, TGG codes for Tryptophan. Amino acids are the Lego building blocks of proteins. 4. The Medusa and the Snail by Lewis Thomas (Penguin, 1995). 2. Catch Me if You Can 1. Dr Tatiana’s Sex Advice to all Creation by Olivia Judson (Vintage, 2003). 2. The information to build an organism is encoded in deoxyribonucleic acid, or DNA, a double-helical molecule inside each cell.
On the Future: Prospects for Humanity by Martin J. Rees
23andMe, 3D printing, air freight, Alfred Russel Wallace, Asilomar, autonomous vehicles, Benoit Mandelbrot, blockchain, cryptocurrency, cuban missile crisis, dark matter, decarbonisation, demographic transition, distributed ledger, double helix, effective altruism, Elon Musk, en.wikipedia.org, global village, Hyperloop, Intergovernmental Panel on Climate Change (IPCC), Internet of things, Jeff Bezos, job automation, Johannes Kepler, John Conway, life extension, mandelbrot fractal, mass immigration, megacity, nuclear winter, pattern recognition, quantitative hedge fund, Ray Kurzweil, Rodney Brooks, Search for Extraterrestrial Intelligence, sharing economy, Silicon Valley, smart grid, speech recognition, Stanford marshmallow experiment, Stanislav Petrov, stem cell, Stephen Hawking, Steven Pinker, Stuxnet, supervolcano, technological singularity, the scientific method, Tunguska event, uranium enrichment, Walter Mischel, Yogi Berra
But much of their essence can nonetheless be captured by a few key insights. Our perspective has been transformed by great unifying ideas. The concept of continental drift (plate tectonics) helps us to fit together a whole raft of geological and ecological patterns across the globe. Darwin’s insight—evolution via natural selection—reveals the overarching unity of the entire web of life on this planet. And the double helix of DNA reveals the universal basis for heredity. There are patterns in nature. There are even patterns in how we humans behave—in how cities grow, how epidemics spread, and how technologies like computer chips develop. The more we understand the world, the less bewildering it becomes and the more we’re able to change it. The sciences can be viewed as a hierarchy, ordered like the floors of a building, with those dealing with more complex systems higher up: particle physics in the basement, then the rest of physics, then chemistry, then cell biology, then botany and zoology, and then the behavioural and human sciences (with the economists claiming the penthouse).
Power Systems: Conversations on Global Democratic Uprisings and the New Challenges to U.S. Empire by Noam Chomsky, David Barsamian
affirmative action, Affordable Care Act / Obamacare, Albert Einstein, American ideology, Chelsea Manning, collective bargaining, colonial rule, corporate personhood, David Brooks, discovery of DNA, double helix, drone strike, failed state, Howard Zinn, hydraulic fracturing, income inequality, inflation targeting, Intergovernmental Panel on Climate Change (IPCC), Julian Assange, land reform, Martin Wolf, Mohammed Bouazizi, Naomi Klein, Nelson Mandela, new economy, obamacare, Occupy movement, oil shale / tar sands, pattern recognition, Powell Memorandum, quantitative easing, Ralph Nader, Ralph Waldo Emerson, single-payer health, sovereign wealth fund, The Wealth of Nations by Adam Smith, theory of mind, Tobin tax, union organizing, Upton Sinclair, uranium enrichment, WikiLeaks
In Science, the journal of the American Association for the Advancement of Science, Bruce Alberts, a biochemist, had a series of editorials on science education.18 What he points out is quite interesting. He says science education is increasingly being designed with the effect of killing any interest in science. If you are in college, maybe you have to memorize a bunch of enzymes or something. If you are in elementary school, you memorize the periodic table. When you study the discovery of DNA, you’re just taught what scientists already discovered. You memorize the fact that DNA is a double helix. Science is being taught in a way that kills any joy in science, gives you no sense of what discovery is. It’s the opposite of Weisskopf’s view that it matters what you discover, not what you cover. Alberts gives some nice examples of alternatives that do work. In one kindergarten class, each kid was given a dish with a mixture of pebbles, shells, and seeds, and asked, “How do we know if something is a seed?”
The Singularity Is Near: When Humans Transcend Biology by Ray Kurzweil
additive manufacturing, AI winter, Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Albert Einstein, anthropic principle, Any sufficiently advanced technology is indistinguishable from magic, artificial general intelligence, Asilomar, augmented reality, autonomous vehicles, Benoit Mandelbrot, Bill Joy: nanobots, bioinformatics, brain emulation, Brewster Kahle, Brownian motion, business cycle, business intelligence, c2.com, call centre, carbon-based life, cellular automata, Claude Shannon: information theory, complexity theory, conceptual framework, Conway's Game of Life, coronavirus, cosmological constant, cosmological principle, cuban missile crisis, data acquisition, Dava Sobel, David Brooks, Dean Kamen, disintermediation, double helix, Douglas Hofstadter, en.wikipedia.org, epigenetics, factory automation, friendly AI, George Gilder, Gödel, Escher, Bach, informal economy, information retrieval, invention of the telephone, invention of the telescope, invention of writing, iterative process, Jaron Lanier, Jeff Bezos, job automation, job satisfaction, John von Neumann, Kevin Kelly, Law of Accelerating Returns, life extension, lifelogging, linked data, Loebner Prize, Louis Pasteur, mandelbrot fractal, Marshall McLuhan, Mikhail Gorbachev, Mitch Kapor, mouse model, Murray Gell-Mann, mutually assured destruction, natural language processing, Network effects, new economy, Norbert Wiener, oil shale / tar sands, optical character recognition, pattern recognition, phenotype, premature optimization, randomized controlled trial, Ray Kurzweil, remote working, reversible computing, Richard Feynman, Robert Metcalfe, Rodney Brooks, scientific worldview, Search for Extraterrestrial Intelligence, selection bias, semantic web, Silicon Valley, Singularitarianism, speech recognition, statistical model, stem cell, Stephen Hawking, Stewart Brand, strong AI, superintelligent machines, technological singularity, Ted Kaczynski, telepresence, The Coming Technological Singularity, Thomas Bayes, transaction costs, Turing machine, Turing test, Vernor Vinge, Y2K, Yogi Berra
Robert Waterston quoted in "Scientists Reveal Complete Sequence of Human Genome," CBC News, April 14, 2003, http://www.cbc.ca/story/science/national/2003/04/14/genome030414.html. 5. See chapter 2, note 57. 6. The original reports of Crick and Watson, which still make compelling reading today, may be found in James A. Peters, ed., Classic Papers in Genetics (Englewood Cliffs, N.J.: Prentice-Hall, 1959). An exciting account of the successes and failures that led to the double helix is given in J. D. Watson, The Double Helix: A Personal Account of the Discovery of the Structure of DNA (New York: Atheneum, 1968). Nature.com has a collection of Crick's papers available online at http://www.nature.com/nature/focus/crick/index.html. 7. Morislav Radman and Richard Wagner, "The High Fidelity of DNA Duplication," Scientific American 259.2 (August 1988): 40–46. 8. The structure and behavior of DNA and RNA are described in Gary Felsenfeld, "DNA," and James Darnell, "RNA," both in Scientific American 253.4 (October 1985), p. 58–67 and 68–78 respectively. 9.
Life's Computer In the very early stages of evolution information was encoded in the structures of increasingly complex organic molecules based on carbon. After billions of years biology evolved its own computer for storing and manipulating digital data based on the DNA molecule. The chemical structure of the DNA molecule was first described by J. D. Watson and F. H. C. Crick in 1953 as a double helix consisting of a pair of strands of polynucleotides.6 We finished transcribing the genetic code at the beginning of this century. We are now beginning to understand the detailed chemistry of the communication and control processes by which DNA commands reproduction through such other complex molecules and cellular structures as messenger RNA (mRNA), transfer RNA (tRNA), and ribosomes. At the level of information storage the mechanism is surprisingly simple.
The Age of Wonder by Richard Holmes
Ada Lovelace, Albert Einstein, animal electricity, British Empire, Copley Medal, Dava Sobel, double helix, Edmond Halley, Etonian, experimental subject, Fellow of the Royal Society, invention of the printing press, Isaac Newton, James Watt: steam engine, Johann Wolfgang von Goethe, John Harrison: Longitude, music of the spheres, placebo effect, polynesian navigation, Richard Feynman, Solar eclipse in 1919, Stephen Hawking, Thomas Kuhn: the structure of scientific revolutions, Thomas Malthus, trade route, unbiased observer, University of East Anglia, éminence grise
, Transactions of the Newcomen Society (2005). Something similar had arisen during the controversy over the John Harrison chronometers. The whole question of ‘scientific priority’ has become a major preoccupation in modern science. See for example the race over the structure of DNA between Crick and Watson at Cambridge, and Rosalind Franklin at Imperial College, as described in James Watson’s classic The Double Helix (1968) and Brenda Maddox’s biography Rosalind Franklin: The Dark Lady of DNA (2002). Carl Djerassi’s play Oxygen (2001) beautifully dramatises an earlier eighteenth-century priority dispute between Priestley, Scheele and Lavoisier. 9 Sorcerer and Apprentice 1 Sir Joseph Banks had been getting older and more infirm, and he hated it. After one particularly bad episode of gout in summer 1816, when he was seventy-three, he grumbled from his retreat at Spring Grove: ‘I fear its probable that I shall be obliged to spend the greater part of my Future Life in a Prostrate Posture…For these 12 or 14 years past my legs have Swelled towards evening…I am so effectually confined to my bed that I am not even allowed to be carried downstairs & placed on a Coach.’
A later edition of the poem was superbly illustrated with William Blake’s watercolour engravings, a consolation for those terrified by the new cosmology. Bibliography The Bigger Picture (In chronological order of publication) Thomas Kuhn, The Structure of Scientific Revolutions, Chicago UP, 1962-70 Albert Bettex, The Discovery of Nature (with 482 illustrations), Thames & Hudson, 1965 James D. Watson, The Double Helix: A Personal Account of the Discovery of the Structure of DNA, 1968/2001 Arthur Koestler, The Act of Creation, Danube edition, 1969 Jacob Bronowski, The Ascent of Man, 1973 Adrian Desmond and James Moore, Darwin, Penguin, 1992 Lewis Wolpert, The Unnatural Nature of Science, Faber, 1992 James Gleick, Richard Feynman and Modern Physics, Pantheon Books, 1992 Michael J. Crowe, Modern Theories of the Universe from Herschel to Hubble, Chicago UP, 1994 Gale Christianson, Edwin Hubble: Mariner of the Nebulae, Farrar, Straus & Giroux, 1995 Peter Whitfield, The Mapping of the Heavens, The British Library, 1995 John Carey (editor), The Faber Book of Science, Faber, 1995 Janet Browne, Charles Darwin: Volume I: Voyaging, and Volume 2: The Power of Place, Pimlico, 1995 and 2000 Michael Shortland and Richard Yeo, Telling Lives in Science: Essays in Scientific Biography, CUP, 1996 Dava Sobel, Longitude, Fourth Estate, 1996 Roy Porter, The Greatest Benefit to Mankind: A Medical History of Humanity from Antiquity to the Present, HarperCollins, 1997 John Gascoigne, Science in the Service of Empire, CUP, 1998 Richard Dawkins, Unweaving the Rainbow: Science, Delusion and the Appetite for Wonder, Allen Lane, Penguin Press, 1998 Lisa Jardine, Ingenious Pursuits: Building the Scientific Revolution, Little, Brown, 1999 Jonathan Bate, The Song of the Earth, Picador, 2000 Ludmilla Jordanova, Defining Features: Scientific and Medical Portraits 1660-2000, National Portrait Gallery, London, 2000 Patricia Fara, Newton: The Making of Genius, Macmillan, 2000 Mary Midgley, Science and Poetry, Routledge, 2001 Thomas Crump, A Brief History of Science as Seen Through the Development of Scientific Instruments, Constable, 2001 Oliver Sacks, Uncle Tungsten: Memories of a Chemical Boyhood, Picador, 2001 Carl Djerassi and Roald Hoffmann, Oxygen (a play in 2 acts), Wiley, New York, 2001 Anne Thwaite, Glimpses of the Wonderful: The Life of P.H.
.), 451 Vesuvius: Davy visits, 356, 358, 378, 381 Victoria, Queen: takes chloroform during childbirth, 284 Vineyard Nurseries, Hammersmith, 11 Vitalism (Life Force), xix, 307, 309-18, 321-3, 325, 327, 354, 356, 421, 428, 431 Volta, Alessandro, 173, 295, 314, 355 voltaic batteries, 245, 273-4, 286, 295, 297, 299, 317, 328-9 Voltaire, François Marie Arouet: in Haydon painting, 319; Candide, 68; Letters on the English Nation, xviiin; Micromégas, 426 Voyager (spacecraft), 190 Wagner, Richard: Tristan and Isolde (opera), 242 Wakefield, Priscilla, 179 Wakley, Thomas, 336 Walker, William: Eminent Men of Science Living in 1807-8 (painting), 303 Waller, Edmund, 424 Wallis, Captain Samuel, 3, 17 Walls End colliery, Northumberland, 361-2, 368-9 Walmer Castle, Kent, 200 Walpole, Horace, 135-8, 140, 338 Walton, Izaak, 276; The Compleat Angler, 339 Wansey (musician), 265 Waterton, Charles, 232, 382; Wanderings in South America, 382 Watson, James: The Double Helix, 373n Watson, Sir William, 60-1, 101 Watson, Sir William, junior: friendship with Herschel, 60-2, 92-3, 98, 100-1, 108-9, 135, 164, 166, 178, 180; and Herschel’s marriage to Mary Pitt, 185-6; and philosophical significance of astronomy, 203 Watt, Gregory: friendship with Davy, 150, 263-4, 266, 275, 362; death, 293-4 Watt, James: recommends Beddoes to Banks, 235; son stays with Davy’s mother, 250; Beddoes seeks financial support from, 251; encourages Beddoes to recruit Davy, 252; Davy visits, 256; in Davy’s nitrous oxide experiments, 263; designs portable gas chamber, 269; letter from Banks on Beddoes’s project, 281 weather forecasting, 160n Webb, T.H., 87 Wedgwood, Thomas, 263, 281 Wedgwood family, 256 Wells, Dr Horace, 283 Wells, Sarah, 49, 53-6, 384 Whewell, William: and John Herschel, 387; supports Wollaston for presidency of Royal Society, 397; and John Herschel’s Study of Natural Philosophy, 441; and formation of British Association, 446-7, 449; and Bridgewater Treatises, 452; reviews Mary Somerville, 459; befriends Charles Darwin, 460; On the Plurality of Worlds, 209 White, Gilbert, 12, 48, 136, 146, 249n Whitehaven Collieries, 369 Wilberforce, William, 386 Wilson, Frances: The Ballad of Dorothy Wordsworth, 187n Windham, William, 140 Wiverou (Tahitian chief), 30 Wollaston, William Hyde, 369, 374, 397-9, 401-2, 417, 436, 438-9 Wollstonecraft, Mary: published by Johnson, 106, 271; earnings, 179; Godwin writes Memoir of, 267; Davy supports, 304 women: earnings and professional status, 179-80; Davy advocates scientific knowledge for education of, 304; and third British Association meeting, 447, 452; membership of British Association, 459 wonder: nature of, xx Woodford, Revd James, 136 Wooster, David: Paula Trevelyan, 460n Wordsworth, Dora (William’s daughter), 203n Wordsworth, Dorothy, 186n, 203n, 249n Wordsworth, John (William’s son), 203n Wordsworth, Mary (née Hutchinson), 186n Wordsworth, William: on Newton, xvi-xvii, 320, 469n; published by Johnson, 106, 271; marriage to Mary Hutchinson, 186n; regional roots, 236; Coleridge visits in Lake District, 267; influence on Davy’s poetry, 276; Davy visits in Lake District, 295; at Haydon’s ‘Immortal Dinner’, 318; in Haydon painting, 319; quarrel with Coleridge, 340; honoured with dinner, 348; on Davy’s decline, 414; John Davy acts as doctor to, 433; effect of poetry on John Stuart Mill, 441; Coleridge on poetry of, 449; Lyrical Ballads (with Coleridge), 254, 275, 291; On Church and State, 449; Peter Bell, 162; The Prelude, 232, 320, 431, 469n; ‘The Tables Turned’, 320; ‘Tintern Abbey’, 316 Wright, Joseph (of Derby): paintings, xix; influenced by Priestley, 246 Wright, Thomas, 77; Original Theory or New Hypothesis of the Universe, 91 Wynn, William, 265 Yansong, West Africa, 230 York, Edward, Duke of (George III’s brother), 75, 177 Young, Edward: Night Thoughts, 92 & n Young, Thomas, 436 Zoffany, Johann, 8, 47 ALSO BY RICHARD HOLMES One for Sorrow (poems) Shelley: The Pursuit Shelley on Love (editor) Gautier: My Fantoms (translations) Nerval: The Chimeras (with Peter Jay) Mary Wollstonecraft and William Godwin: A Short Residence in Sweden and Memoirs (editor, Penguin Classics) De Feministe en de Filosoof Dr Johnson & Mr Savage Coleridge: Early Visions Coleridge: Darker Reflections Coleridge: Selected Poems (editor, Penguin Classics) Footsteps: Adventures of a Romantic Biographer Sidetracks: Explorations of a Romantic Biographer Insights: The Romantic Poets and their Circle Classic Biographies (series editor) Copyright HarperPress An imprint of HarperCollinsPublishers 77-85 Fulham Palace Road, Hammersmith, London W6 8JB www.harpercollins.co.uk Published by HarperPress in 2008 Copyright © Richard Holmes 2008 FIRST EDITION The author asserts the moral right to be identified as the author of this work A catalogue record for this book is available from the British Library EPub Edition © SEPTEMBER 2009 ISBN: 978-0-007-34988-3 All rights reserved under International and Pan-American Copyright Conventions.
The Driver in the Driverless Car: How Our Technology Choices Will Create the Future by Vivek Wadhwa, Alex Salkever
23andMe, 3D printing, Airbnb, artificial general intelligence, augmented reality, autonomous vehicles, barriers to entry, Bernie Sanders, bitcoin, blockchain, clean water, correlation does not imply causation, distributed ledger, Donald Trump, double helix, Elon Musk, en.wikipedia.org, epigenetics, Erik Brynjolfsson, Google bus, Hyperloop, income inequality, Internet of things, job automation, Kevin Kelly, Khan Academy, Kickstarter, Law of Accelerating Returns, license plate recognition, life extension, longitudinal study, Lyft, M-Pesa, Menlo Park, microbiome, mobile money, new economy, personalized medicine, phenotype, precision agriculture, RAND corporation, Ray Kurzweil, recommendation engine, Ronald Reagan, Second Machine Age, self-driving car, Silicon Valley, Skype, smart grid, stem cell, Stephen Hawking, Steve Wozniak, Stuxnet, supercomputer in your pocket, Tesla Model S, The Future of Employment, Thomas Davenport, Travis Kalanick, Turing test, Uber and Lyft, Uber for X, uber lyft, uranium enrichment, Watson beat the top human players on Jeopardy!, zero day
Christened Mycoplasma mycoides JCVI-syn1.0, also known as “Synthia,” the slow-growing, harmless bacterium was made of a synthetic genome with 1,077,947 DNA base pairs. To make Synthia, Venter’s team inserted a synthetic genome into a cell containing no DNA. The technology that Venter used to “write” the genes of this new organism is the equivalent of a laser printer that can “print” DNA. DNA has a fairly simple structure, with a double helix containing linked chains of nucleic acids. Already there are a number of DNA print providers, such as Thermo Fisher Scientific and GeneArt, that will sell DNA synthesis and assembly operations as a service. Current pricing is by the number of amino-acid base pairs—the chemical components of a gene—that are to be assembled. From 2003 to 2015, assembly costs plummeted from $4 to 20 cents per base pair; and in March 2016, one company, Gen9, offered assembly for 3 cents per base pair of long DNA constructs.7 It is very likely that, in the early 2030s, it will be possible to search for genetic designs on the Web, download them to your computer, and modify and adapt them to your needs.
The Greatest Show on Earth: The Evidence for Evolution by Richard Dawkins
Alfred Russel Wallace, Andrew Wiles, Arthur Eddington, back-to-the-land, Claude Shannon: information theory, correlation does not imply causation, Craig Reynolds: boids flock, Danny Hillis, David Attenborough, discovery of DNA, Dmitri Mendeleev, double helix, en.wikipedia.org, epigenetics, experimental subject, if you see hoof prints, think horses—not zebras, invisible hand, Louis Pasteur, out of africa, phenotype, Thomas Malthus
This is where we leave our analogy with books and scrolls and go straight to the real thing because, as it happens, the real thing – DNA – is easier to understand than the analogy! If you gradually heat DNA, there comes a point – somewhere around 85°C – when the bonding between the two strands of the double helix breaks, and the two helices separate. You can think of 85°C, or whatever the temperature turns out to be, as a ‘melting point’. If you let it cool again, each single helix spontaneously joins up again with another single helix, or fragment of single helix, wherever it finds one with which it can pair, using the ordinary base-pairing rules of the double helix. You might think that this would always be the partner from which it lately separated, and with which, of course, it is perfectly matched. Indeed it could be, but it usually isn’t as tidy as that. Fragments of DNA will find other fragments with which they can pair, and they will usually not be exactly their original partners.
From Bacteria to Bach and Back: The Evolution of Minds by Daniel C. Dennett
Ada Lovelace, Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Andrew Wiles, Bayesian statistics, bioinformatics, bitcoin, Build a better mousetrap, Claude Shannon: information theory, computer age, computer vision, double entry bookkeeping, double helix, Douglas Hofstadter, Elon Musk, epigenetics, experimental subject, Fermat's Last Theorem, Gödel, Escher, Bach, information asymmetry, information retrieval, invention of writing, Isaac Newton, iterative process, John von Neumann, Menlo Park, Murray Gell-Mann, Necker cube, Norbert Wiener, pattern recognition, phenotype, Richard Feynman, Rodney Brooks, self-driving car, social intelligence, sorting algorithm, speech recognition, Stephen Hawking, Steven Pinker, strong AI, The Wealth of Nations by Adam Smith, theory of mind, Thomas Bayes, trickle-down economics, Turing machine, Turing test, Watson beat the top human players on Jeopardy!, Y2K
In other words, cognitive scientists today are roughly in the position that evolutionary theorists and geneticists were in before the analysis of the structure of DNA: they knew that information about phenotypic features—shapes of bodily parts, behaviors, and the like—was somehow being transmitted down through the generations (via “genes,” whatever they were), but they didn’t have the ACGT code of the double helix to provide them with a Shannon measure of how much information could be passed from parent to offspring as genetic inheritance. Some thinkers, perhaps inspired by DNA, think that there must be an encoding in the nervous system like the DNA code, but I have never seen a persuasive argument for this, and as we will soon see, there are reasons for skepticism. Semantic information, the concept of information that we must start with, is remarkably independent of encodings, in the following sense: two or more observers can acquire the same semantic information from encounters that share no channel.24 Here is a somewhat contrived example: Jacques shoots his uncle dead in Trafalgar Square and is apprehended on the spot by Sherlock.
After decades of research and development, speech-recognition software is finally almost as competent as a five-year-old child at extracting the phonemes of casual speech from the acoustic maelstrom that arrives at an ear or a microphone. The digitization of phonemes has a profound implication: words play a role in cultural evolution that is similar to the role of DNA in genetic evolution, but, unlike the physically identical ladder rungs in the double helix made of Adenine, Cytosine, Guanine, and Thymine, words are not physically identical replicators; they are “identical” only at the user-illusion level of the manifest image. Words, one might say, are a kind of virtual DNA, a largely digitized medium that exists only in the manifest image. Millions of acorns and apples are broadcast into the world by oak trees and apple trees “in hopes of” starting new descendants.
The Strangest Man: The Hidden Life of Paul Dirac, Mystic of the Atom by Graham Farmelo
Albert Einstein, anti-communist, Arthur Eddington, Berlin Wall, cuban missile crisis, double helix, Ernest Rutherford, Fall of the Berlin Wall, Fellow of the Royal Society, financial independence, gravity well, Henri Poincaré, invention of radio, invisible hand, Isaac Newton, John von Neumann, Kevin Kelly, Murray Gell-Mann, period drama, Richard Feynman, Simon Singh, Solar eclipse in 1919, Stephen Hawking, strikebreaker, University of East Anglia
The directorship of the Cavendish passed to the crystallographer Sir Lawrence Bragg, who steered the laboratory away from studies of the innermost structure of matter, partly because it could no longer keep up with the competition from the United States. With Rutherford’s passing, the Cavendish had seen the last of its glory days as a place where experimenters probed atoms with the finest possible probes, though Bragg steered the laboratory’s agenda into productive territory, culminating in Watson and Crick’s discovery of the double-helix structure of DNA in 1953. By the end of 1937, Dirac was bereft of the company of experimenters with similar interests in physics, and some of his most valued colleagues among the Cambridge theoreticians were in decline. Following a debilitating stroke, Fowler’s health was failing, and, by early 1939, he had ‘faded out’, as he told Eddington.43 In the sometimes gory seminars in the mathematics department, Eddington was timorous and unable to defend himself against pillory by his younger colleagues.
Rubenstein (eds), Understanding Autism: From Basic Neuroscience to Treatment, New York: Taylor & Francis, pp. 175–204. Wali, K. C. (1991) Chandra: A Biography of S. Chandrasekhar, Chicago, Ill.: University of Chicago Press. Walters, B. (1970) How to Talk with Practically Anybody About Practically Anything, New York: Doubleday & Co., Inc. Warwick, A. (2003) Masters of Theory: Cambridge and the Rise of Mathematical Physics, Chicago, Ill.: University of Chicago Press. Watson, J. D. (1980) The Double Helix, ed. G. S. Stent, New York: W. W. Norton & Co. Wattenberg, A. (1984) ‘December 2, 1942: The Event and the People’, in R. G. Sachs (ed.), The Nuclear Chain Reaction: Forty Years Later, Chicago, Ill.: University of Chicago Press, pp. 43–53. Weart, S. and Weiss Szilard, G. (eds) (1978) Leo Szilard: His Version of the Facts, Cambridge, Mass.: MIT Press. Weinberg, S. (2002) ‘How Great Equations Survive’, in G.
D. ceremony 1 lack of employment 1, 2, 3, 4 chauffeurs her father to and from work 1 forced to sell her car 1 family radio 2 and her parents’ marriage crisis 1 degree studies 1, 2, 3, 4, 5 goes to Lourdes with her father 1 supports her parents 1 moves to London to become a secretary 1, 2 in Budapest 1, 2 possible reason for her parents’ failed marriage 1, 2n11 marries Joe Teszler 1 lives in Amsterdam 1 birth of son 1 in the Second World War 1, 2, 3 stays in Cambridge 1 her suffering in Budapest 1 birth of daughter 1 relationship with Manci 1, 2 in Alicante 1 stroke 1 Dirac, Charente, France 1 Dirac, Charles (PD’s father) 1, 2, 3, 4 birth (in Monthey, Switzerland) 1 childhood 1 education 1 in London 1 teaches at Merchant Venturers’ Secondary School 1, 2, 3, 4, 5 settles in Bristol 1, 2 appearance 1, 2, 3, 4, 5 personality 1, 2, 3, 4, 5 meets Florence Holten 1, 2 and religion 1, 2, 3, 4, 5 marries Flo 1, 2 insistence on his children speaking French 1, 2, 3, 4, 5 champions Esperanto in Bristol 1 relationship with PD 1, 2, 3, 4, 5, 6, 7 careful with money 1, 2, 3, 4, 5, 6 work ethic 1, 2, 3, 4 effects of his rigorous educational regime at home 1 tyranny of 1, 2, 3, 4, 5 his favourite child 1, 2, 3 forces Felix to study engineering instead of medicine 1, 2 deceptions by 1, 2 acquires British nationality 1, 2 efforts to send PD to Cambridge 1, 2, 3 helps PD financially 1, 2, 3, 4 interest in PD’s career 1, 2, 3, 4 family radio 1 deeply affected by the death of Felix 1, 2, 3, 4, 5 death of his mother 1 attends PD’s Ph.D. ceremony 1 letters to his ‘only son’ 115, 1 vegetarianism 1, 2 PD continues to feel intimidated by 1 and PD’s FRS election 1, 2 retirement 1, 2 infidelity 1, 2, 3 marriage crisis 1, 2, 3, 4 loses his grip on his family 1 continues to teach from home 1, 2 plans to visit Geneva 1 rediscovery of his childhood Catholicism 1 visits Geneva with Betty 1 Flo attacks in the Swedish press 1 tries to understand PD’s work 1, 2 goes to Lourdes 1 ill with pleurisy 1 serial tax evader 1 PD blames him for Felix’s suicide 1 ‘loathed’ by PD 1, 2n45 death and funeral 1 his estate 1 gravestone 1 Dirac, Felix (PD’s brother) 1, 2 birth 1 names 1n16 appearance 1, 2, 3, 4, 5, 6n32 education 1, 2, 3, 4, 5, 6, 7, 8, 34, 9 childhood in Bristol 1, 2, 3, 4, 5 bullied by his father 1, 2 personality 1, 2, 3 rift with PD 1, 2, 3, 4, 5, 6 forced to study engineering instead of medicine 1 student apprenticeship in Rugby 1, 2 based near Wolverhampton 1, 2 a draughtsman 1 Buddhism and astrology 1 acquires a girlfriend 1 settles in Birmingham 1 volunteers for the Ambulance Corps 1 leaves his job at a machine-testing laboratory 1 personality 1, 2, 3 suicide 1, 2, 3, 4, 5, 6, 7, 8, 9n7 the family’s response to his death 1, 2, 3, 4, 5, 6 memorial service and inquest 1 gravestone 1 Dirac, Florence (née Holten; PD’s mother) 1, 2, 3, 4 first meets Charles 1, 2 appearance 1, 2 personality 1, 2, 3 absent-minded 1, 2 and religion 1 correspondence with Charles 1, 2 marries Charles 1 birth of Felix 1 birth of Paul 1 poem about PD 1, 2n49 Paul as her favourite child 1, 2 and Charles’s deception 1 correspondence with PD 1, 2, 3, 4, 5, 6, 7, 8, 9n29 fears competition for PD’s affections 1, 2, 3, 4, 5 asks PD for money 1, 2, 3 and the death of Felix 1 poetry 1, 2, 3n16, 4n34, 5n49, 6n15, 7n49 interest in politics 1, 2 attends PD’s Ph.D. ceremony 1 worried about PD’s emaciated appearance 1 evening classes 1, 2, 3, 4n17 admits her unhappiness 1, 2, 3 housework, dislike of 1, 2 PD pays for a diamond ring 1, 2 PD’s visits home 1, 2 visits PD in Cambridge 1 and PD’s visits to Russia 1, 2 opposes the idea of a woman prime minister 1 fussing over PD 1 and PD’s FRS election 1 dreads Charles’s retirement 1 the charade of her marriage 1, 2 affinity with the sea 1, 2; see also Richard Holten (her father) marriage crisis 1, 2, 3, 4 Mediterranean cruises 1, 2, 3 at PD’s Nobel Prize ceremony 1, 2 at Bohr’s party in Copenhagen 1, 2 and Charles’s pleurisy 1 meets Manci 1 disputes with Manci 1, 2 in the Second World War 1, 2, 3, 4, 5 death and funeral 1 Dirac, Gabriel (PD’s step-son) 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13n26 Dirac, Gisela 1 Dirac, Judy (PD’s step-daughter) 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 Dirac, Louis (PD’s paternal grandfather) 1, 2n10 Dirac, Margit (Manci; née Wigner; PD’s wife) 1, 2, 3, 4 meets PD 1 personality 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and PD’s talk of his unhappy childhood 1, 2 on her first marriage and divorce 1, 2 and religion 1, 2, 3 a keen follower of the arts 1, 2, 3 pursuit of PD 1, 2 PD visits her in Budapest 1, 2 Isabel Whitehead’s assessment 1 PD’s proposal of marriage 1 marriage and honeymoon 1 relationship with Betty 1, 2, 3, 4, 5, 6 ‘Wigner’s sister’ appellation 1, 2n17 settles in Cambridge 1 in the Soviet Union 1 pregnancies 1, 2, 3, 4n10 as an alien in wartime England 1 and air raids on Cambridge 1 Flo helps with housework 1 orders Judy out of the house 1 and the Nazi concentration camps 1 complains about the exodus from Cambridge 1 scorns Heisenberg 1 in Princeton 1 and politics 1, 2 marriage under strain 1, 2, 3 a better wife than mother 1 and disappearance of Judy 1, 2 worsening arthritis 1, 2 and PD’s decision to move to Florida State University 1 at Florida State 1, 2, 3 Jewish and occasionally anti-Semitic 1, 2n16 as a hostess 1, 2 fraught relationship with Halpern 1, 2, 3 PD’s death and funeral 1 lively and active for ten years after PD’s death 1 letter from Hillary Rodham Clinton 1 death 1 Dirac, Mary (PD’s daughter; later Colleraine, then Tilley) 1, 2, 3, 4, 5, 6, 7, 8 birth 1 childhood 1, 2, 3 personality 1 education 1 emigration to the USA 1, 2 Dirac, Monica (PD’s daughter) 1, 2 birth 1 childhood 1, 2, 3, 4 personality 1 at PD’s commemoration 1 Dirac, Paul Adrien Maurice LIFE STORY birth (8 August 1902) 1 appearance and dress sense 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28n32 digestive problems 1, 2, 3, 4, 5 foresees the existence of the positron 1, 2, 3, 4, 5, 6 childhood in Bristol 1, 2, 3, 4, 5, 6, 7 relationship with his father 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 nicknamed ‘Tiny’ 10, 1 school education 1, 2, 3 visits Switzerland 1, 2 Bristol accent 1, 2, 3, 4, 5n36 and technical drawing 1, 2, 3, 4, 5, 6n44 handwriting 1, 2, 3 his mother’s favourite 1, 2 rift with Felix 1, 2, 3, 4, 5, 6 engineering degree 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 public impact of relativity theory 1 trainee engineer in Rugby 1, 2 applied maths degree studies 1 and projective geometry 1, 2, 3, 4, 5, 6, 7 wins scholarships to St John’s College, Cambridge 1 supervision by Fowler 1, 2, 3, 4, 5, 6, 7, 8 Charles helps him financially 1 arrives at Cambridge 1 manner at the dinner table 1, 2 attends Eddington’s lectures 1 Blackett and Kapitza become his closest friends 1 and Soviet ideology 1, 2, 3 and his mother’s possessiveness 1 first academic papers 1, 2 Felix’s death 1, 2, 3, 4, 5, 6 first great epiphany 1 first paper on quantum mechanics 1, 2 Ph.D. thesis 1 combines logic and intuition 1, 2 as ‘the strangest man’ (Bohr) 1 successful period in Copenhagen 1, 2, 3 in Göttingen 1, 2, 3 friendship with Oppenheimer 1, 2, 3, 4, 5, 6, 7, 8 his visits home 1, 2, 3, 4 elected Fellow of St John’s College 1 his rooms in college 1 makes his most famous contribution to science 1 relationship with Isabel Whitehead 1 first visit to Russia 1 reductionism 1 first visit to US 1, 2 elected Fellow of the Royal Society 1, 2n10 buys his first car 1 represented in a special version of Faust 1, 2 Lucasian Chair 1, 2, 3, 4 Wittgenstein, opinion of 1 and moral philosophy 1 works with Kapitza in his laboratory 1, 2 last meeting with Ehrenfest 1 Nobel Prize for physics 1, 2, 3n20 first public comment on social and economic affairs 1 smitten with Rho Gamow 1, 2 first meets Manci 1 campaign for Kapitza’s release 1, 2, 3, 4 sends the Gamows a baby alligator 1, 2n43 guardian of Kapitza’s sons 1, 2 graduate supervisor 1 proposes to Manci 1 marriage and honeymoon 1 first love letter 1 wants his own children 1, 2n23 refuses Princeton’s job offer 1, 2n50 Scott lecture 1 offered war work 1 Baker Medal 1 and the death of his mother 1 refused a visa for the Soviet Union 1, 2n46 declines honours 1, 2 refused a US visa 1, 2 visits India 1 jaundice 1, 2n37 marriage under strain 1, 2 marginalised in Cambridge 1, 2, 3 emigration to US 1, 2, 3 Scientific American article (1963) 1, 2n10 Horizon interview (1965) 1, 2n11 quarks, likes concept of 1 decision to move to Florida State University 1 routine at Florida State 1 busts and paintings of PD 1 accepts the Order of Merit 1 visits CERN 1 flies on Concorde 1 sees his life as a failure 1 surgery on tubercular kidney 1 death (20 October 1984) 1, 2n17 funeral 1, 2n19 commemoration in Westminster Abbey 1 centenary of his birth 1, 2 possible autism 1 names 1n16 memorial stone 490n27 PERSONALITY – aloofness 1, 2, 3 – confident 1, 2, 3, 4, 5, 6 – defensiveness 1, 2 – determination 1, 2, 3, 4, 5, 6 – diffidence 1, 2 – equability 1 – frugality 1 – inhibition 1 – lack of social sensitivity 1, 2, 3, 4, 5, 6, 7, 8, 9 – literal-mindedness 1, 2, 3, 4, 5n44 – modesty 1, 2, 3, 4, 5 – narrow-mindedness 1 – objectivity 1 – obsession with taking long walks 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17n28, 18n46 – otherworldiness 1, 2, 3, 4 – passivity 1 – physical ineptitude 1, 2 – private enthusiasms 1, 2 – reticence 1, 2, 3, 4, 5, 6, 7, 8 – rigid pattern of activities 1, 2, 3, 4, 5, 6, 7, 8 – self-centredness 1, 2, 3 – shyness 1, 2, 3 – stubborness 1, 2, 3 – taciturnity 1, 2, 3, 4, 5 – top-down thinker 1, 2, 3 – verbal economy 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 – work ethic 1, 2, 3, 4, 5 INTERESTS, APTITUDES AND OPINIONS – beauty, mathematical, fascination with 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 – board games and mathematical puzzles, enjoyment of 1, 2, 3, 4, 5, 6, 7, 8, 9n6 – driver, skills as a 1, 2, 3, 4, 5, 6 – fondness for Mickey Mouse films 1, 2, 3, 4n5 – food, tastes and appetite 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14n6, – gardening 1, 2, 3, 4, 5, 6, 7n33 – Hamiltonian approach to mechanics, strong belief in 1, 2, 3, 4, 5, 6, 7, 8 – jokes, appreciation of 1, 2, 3, 4, 5, 6, 7n10 – lecturer, skills as a 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16n11 – mountain-climbing 1, 2, 3, 4 – philosophy, opinion of 1, 2, 3, 4, 5, 6, 7, 8 – relativity, fascination with 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 – religion, opinions about 1, 2, 3, 4, 5, 6, 7, 8, 9n45, – renormalisation, distaste for and dislike of 1, 2, 3, 4, 5, 6, 7, 8, 9 – swimming 1, 2, 3 – team games and teams, aversion to participation in 1, 2, 3 – technology of space flight, interest in 1, 2, 3 – top-down thinking 1, 2, 3 – tree-climbing 1, 2, 3n17 CONTRIBUTIONS TO PHYSICS AND MATHEMATICS – action principle in quantum mechanics 1, 2, 3, 4 – antimatter, foresees, see also positron and antiproton 1, 2, 3, 4, 5 – anti-electron predicts, see positron – anti-proton, predicts 1 – blackbody radiation spectrum derived 1 – bra and ket notation 1 – classical theories of the electron 1, 2 – cosmology, thoughts on 1, 2, 3, 4 – density matrix 1 – delta function 1, 2n20 – Dirac equation 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 n30, – Dirac sea 1, 2 – dispersion theory 1 – ether, post-Einstein view of 1 – Fermi-Dirac statistics 1, 2, 3 – general relativity, Hamiltonian formulation of 1, 2, 3 – gravity, weakening of – postulates, see also large numbers hypothesis 1 – high-spin theory 1 – hole theory 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21n7 – indefinite metric 1 – jet-stream method of isotope separation 1, 2, 3, 4, 5, 6 – Kapitza-Dirac effect 1, 2, 3, 4, 5n27 – large numbers hypothesis 1, 2, 3, 4, 5n13 – magnetic monopole 1, 2, 3, 4, 5, 6, 7, 8n5, 9n48 – many-times formulation of quantum electrodynamics by PD, Fock and Podolsky 1, 2n25 – neutron diffusion in matter, theory of 1, 2 – non-commutation in quantum mechanics 1, 2, 3, 4, 5, 6n11 – parity violation, foresees possibility of 1 – philosophy of physical science 1, 2, 3 – Poisson bracket in quantum mechanics 1 – positron, prediction of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13n34 – principle of mathematical beauty 1, 2 – quantum electrodynamics 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21n25 – quantum field theory, co-discovery see quantum electrodynamics 1 – quantum mechanics of heavy atoms 1 – quantum mechanics, later contributions 1, 2, 3 – Schrödinger equation (time dependent), independent discovery by PD 1 – sphere, quantum-relativistic treatment of 1, 2 – spinors 1 – string concept in quantum electrodynamics 1, 2 – transformation theory 1 – vacuum polarisation 1 – virtual states 1 THE ARTS, TASTE AND APPRECIATION OF – art (visual) 1, 2, 3, 4, – cinema 1, 2, 3 – comics and comic characters 1, 2, 3, 4, 5, 6, 7, 8, 9, 10n6, 11n5 – music 1, 2, 3, 4, 5, 6, 7n15 – novels 1, 2, 3, 4, 5, 6, 7, 8 – poetry 1, 2, 3 – radio and television, appreciation of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 – theatre and opera 1, 2, 3, 4, 5, 6 BOOKS – General Theory of Relativity 1 – Principles of Quantum Mechanics 1, 2, 3, 4, 5, 6, 7, 8, 9, 10n49 Dirac, unofficial unit of frequency of speech 1 Dirac, Walla (PD’s paternal grandmother) 1, 2, 3, 4, 5n16 ‘Dirac stories’ 120, 1, 2, 3 DNA, double-helix structure of 1 Dneproges hydroelectric power station 1 Dobb, Maurice 1 Dostoevsky, Fyodor: Crime and Punishment 1 Douglas’ Works, Kingswood 1n16 Dublin 1 Dublin conference (1942) 1 Durango, Colorado 1 Duranty, Walter 1 Dutton, S. T.: Social Phases of Education in the School and the Home 1 Dyson, Freeman 1, 2, 3, 4, 5, 6n31, 7n11, 8n6, 9n13, 10n45 Eddington, Sir Arthur 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 mathematician and astronomer 1, 2 understanding of relativity theory 1 solar-eclipse experiments 1, 2, 3, 4 on Einstein’s E = mc2 equation 1 introduces PD to relativity 1 appearance 1 personality 1, 2 mathematical approach to science 1 and Rutherford 1 congratulates PD on his Ph.D. thesis 1 and the splitting of the atom 1 media savvy 1 pilloried by his younger colleagues 1 and nuclear energy 1, 2n60 disagreement with PD 1 Dublin conference (1942) 1 death 1 The Mathematical Theory of Relativity 1n20 The Nature of the Physical World 1 Space, Time and Gravitation 1 Edward VII, King 1 Ehrenfest, Paul 1, 2, 3, 4, 5, 6, 7, 8, 9 Ehrenhaft, Felix 1n48 Einstein, Albert 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18n20 personality 1 most successful spurt of creativity 1 appearance 1, 2 studies Mill’s System of Logic 1 E = mc2 equation 1, 2, 3, 4, 5 and Planck’s blackbody radiation spectrum formula 1 and solar eclipse results 1 light quanta idea 1 and Bohr 1 and Heisenberg’s theory of 1925 1 suspicious of the new quantum mechanics 1, 2 top-down approach to physics 1 on PD 1, 2 stimulated emission process and the laser 1 attacks Heisenberg’s uncertainty principle 1 differs from PD in his approach to science 1 praises PD’s textbook 1 at the 1930 Solvay Conference 1 despises Hitler 1 Nazis’ view of his ‘Jewish physics’ 1 and the photon 1 and the splitting of the atom 1 flees from Germany to the USA 1, 2 at Princeton 1, 2, 3, 4 and Kapitza’s detention 1, 2 dislike of quantum electrodynamics 1 treats Heisenberg with contempt 1 Hoover’s campaign against 1 suggests the existence of a positive electron 1 in search of generalisations 1 death 1 centenary of his birth 1, 2 ‘Electron and General Relativity’ 1n34 see also relativity Eisenhower, Dwight D. 1 electrical charge 1, 2 electromagnetic interaction 1 electromagnetism 1 laws of 1, 2 Maxwell’s theory 1, 2, 3, 4, 5, 6 PD’s magnetic monopole theory 1 electron-positron pairs 1, 2 electrons bare 1, 2 behaving as discrete particles 1 Cavendish annual dinner, toast to 1 describing behaviour of a single, isolated electron 1 diffraction by light 1, 2 Dirac equation 1, 2, 3 discovered by J.
Navel Gazing: True Tales of Bodies, Mostly Mine (But Also My Mom's, Which I Know Sounds Weird) by Michael Ian Black
Martha’s attitude does not dissuade me from opening my own test box. I’m not sure what I expect to find inside, but I assume there will be an assortment of science gizmos including: a hypodermic needle, a high-speed centrifuge, a DNA sequencer, safety goggles, and a tabletop laser. Not so. The box contains exactly one (1) plastic spittoon and one (1) mail-in envelope. I shake out the box, but that’s it. Hm. Shouldn’t the process for untangling my personal double helix be a bit more Star Treky than filling a plastic cup with spit? It takes ten minutes of effortful expectorating to fill the cup. When I finish, I hold it up to the light, the way schoolkids do conducting experiments on pond water. Somewhere in that watery goop is my fate. I seal up the envelope and mail it off to the future. A couple weeks later, I receive an e-mail informing me that my results are ready for viewing.
The Misfit Economy: Lessons in Creativity From Pirates, Hackers, Gangsters and Other Informal Entrepreneurs by Alexa Clay, Kyra Maya Phillips
Airbnb, Alfred Russel Wallace, Berlin Wall, Burning Man, collaborative consumption, conceptual framework, creative destruction, different worldview, disruptive innovation, double helix, fear of failure, game design, Hacker Ethic, Howard Rheingold, informal economy, invention of the steam engine, James Watt: steam engine, Joseph Schumpeter, Kickstarter, lone genius, Mark Zuckerberg, mass incarceration, megacity, Occupy movement, peer-to-peer rental, Ronald Reagan, Rosa Parks, sharing economy, Silicon Valley, Steve Jobs, Steven Levy, Stewart Brand, supply-chain management, union organizing, Whole Earth Catalog, Whole Earth Review, Zipcar
Many of us cleave to our own ideas. But part of learning to innovate is recognizing that other people sometimes have better ideas, and that what we think are “our” thoughts are not our ideas at all but ours to witness. How often have you had what you were certain was an original thought or concept only to discover that others had it, too, either prior or simultaneously? The discovery of the double-helix structure of DNA is one example—James Watson and Francis Crick are known to have been working on the problem at the University of Cambridge while Rosalind Franklin and Maurice Wilkins at the University of London did the same.10 The theory of evolution, while largely accredited to Charles Darwin, was independently conceived by British biologist Alfred Russel Wallace. Wallace sent Darwin a letter outlining his theories of evolution.
Player One by Douglas Coupland
We are either borne along by it or drowned in it.” Proteinic Inevitability The tendency for life-forming molecules to aggregate and create life the first moment they possibly can. So dedicated are they to this cause, recent research suggests that in the beginning stages of life on earth, small molecules acted as “molecular midwives,” assisting in the formation of life-creating polymers and appropriate selection of base pairs for the DNA double helix. Pseudoalienation The inability of humans to create genuinely alienating situations. Anything made by humans is a de facto expression of humanity. Technology cannot be alienating because humans created it. Genuinely alien technologies can be created only by aliens. Technically, a situation one might describe as alienating is, in fact, “humanating.” Punning Syndrome The medicalization of what was previously considered merely an annoying verbal tic displayed by a limited number of people.
The Great Derangement: Climate Change and the Unthinkable by Amitav Ghosh
Alfred Russel Wallace, Berlin Wall, Bernie Sanders, British Empire, carbon footprint, Donald Trump, double helix, Fellow of the Royal Society, Intergovernmental Panel on Climate Change (IPCC), invisible hand, James Watt: steam engine, Mahatma Gandhi, market fundamentalism, megacity, Naomi Klein, non-fiction novel, Ronald Reagan, spinning jenny, Upton Sinclair, upwardly mobile, urban planning
Contemporary culture in all its aspects (including religious fundamentalisms of almost every variety) is pervaded by this expressivism, which is itself ‘to a significant degree a result of the strong role of Protestant Christianity in the making of the modern world’. There could be no better vehicle for this expressivism than the Internet, which makes various means of self-expression instantly available through social media. And as tweets and posts and clips circle the globe, they generate their mirror images of counter-expression in a dynamic that quickly becomes a double helix of negation. As far back as the 1960s Guy Debord argued in his seminal book The Society of the Spectacle: ‘The whole life of those societies in which modern conditions of production prevail presents itself as an immense accumulation of spectacles. All that was once directly lived has become mere representation.’ The ways in which political engagements unfold over social media confirm this thesis, propounded long before the Internet became so large a part of our lives: ‘The spectacle is by definition immune from human activity, inaccessible to any projected review or correction.
Half Empty by David Rakoff
When Dad presses his button, for example, the room adjusts itself to his various preprogrammed preferences: lighting, shades up or shades down, music playing, even the images that are displayed in the many digital picture frames all around. For Brian, who is an architect, the photos switch to things structural: an ink drawing of the Leaning Tower of Pisa, a view of London with Norman Foster’s Gherkin office tower visible, as well as the double-helix ramps in his dome for the Reichstag in Berlin. Atkins is an incredibly friendly guy who, while having enjoyed the experience of working on the Dream Home, hardly seems like a Kool-Aid drinker. He is pleased when I can identify a wall mural as being in the style of Maxfield Parrish, and downright thrilled when we enter the home for the first time and he has us turn left, because most people turn right, and I say “Paco Underwood,” referring to the retail anthropologist who observed this phenomenon (something I only know from reading Malcolm Gladwell).
The Lights in the Tunnel by Martin Ford
"Robert Solow", Albert Einstein, Bill Joy: nanobots, Black-Scholes formula, business cycle, call centre, cloud computing, collateralized debt obligation, commoditize, creative destruction, credit crunch, double helix, en.wikipedia.org, factory automation, full employment, income inequality, index card, industrial robot, inventory management, invisible hand, Isaac Newton, job automation, John Markoff, John Maynard Keynes: Economic Possibilities for our Grandchildren, John Maynard Keynes: technological unemployment, knowledge worker, low skilled workers, mass immigration, Mitch Kapor, moral hazard, pattern recognition, prediction markets, Productivity paradox, Ray Kurzweil, Search for Extraterrestrial Intelligence, Silicon Valley, Stephen Hawking, strong AI, technological singularity, Thomas L Friedman, Turing test, Vernor Vinge, War on Poverty
In the future, we may be able to build molecular machines: tiny inventions, far smaller than the head of a pin, that can essentially transform matter and create nearly anything we want out of the most basic ingredients. This may seem like pure fantasy until we learn that nanotechnology is already here and has been operating since long before human beings walked the earth.* It is all around us and even inside us. All living things, at the most basic level, operate under the direction of molecular machines. We know that our genetic recipe is encoded in the double helix-shaped DNA molecules in the nucleus of our cells. But how does that recipe get translated into an incomprehensibly complex organism like a human being? *[ I am referring here to truly advanced nanotechnology or “molecular machines.” A number of techniques and processes which are currently in use are referred to as “nanotechnology,” but these really represent the leading edge of traditional materials science.
Essentialism: The Disciplined Pursuit of Less by Greg McKeown
Albert Einstein, Clayton Christensen, Daniel Kahneman / Amos Tversky, deliberate practice, double helix, en.wikipedia.org, endowment effect, Isaac Newton, iterative process, Jeff Bezos, Lao Tzu, lateral thinking, loss aversion, low cost airline, Mahatma Gandhi, microcredit, minimum viable product, Nelson Mandela, North Sea oil, Peter Thiel, Ralph Waldo Emerson, Richard Thaler, Rosa Parks, Shai Danziger, side project, Silicon Valley, Silicon Valley startup, sovereign wealth fund, Stanford prison experiment, Steve Jobs, Vilfredo Pareto
Given that, it should hardly be surprising that key breakthroughs in thinking have taken place in times of play. Hallowell writes: “Columbus was at play when it dawned on him that the world was round. Newton was at play in his mind when he saw the apple tree and suddenly conceived of the force of gravity. Watson and Crick were playing with possible shapes of the DNA molecule when they stumbled upon the double helix. Shakespeare played with iambic pentameter his whole life. Mozart barely lived a waking moment when he was not at play. Einstein’s thought experiments are brilliant examples of the mind invited to play.”9 Of Work and Play Some innovative companies are finally waking up to the essential value of play. The CEO of Twitter, Dick Costolo, promotes play through comedy; he instigated an improv class at the company.
Turing's Cathedral by George Dyson
1919 Motor Transport Corps convoy, Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, Albert Einstein, anti-communist, Benoit Mandelbrot, British Empire, Brownian motion, cellular automata, cloud computing, computer age, Danny Hillis, dark matter, double helix, fault tolerance, Fellow of the Royal Society, finite state, Georg Cantor, Henri Poincaré, housing crisis, IFF: identification friend or foe, indoor plumbing, Isaac Newton, Jacquard loom, John von Neumann, mandelbrot fractal, Menlo Park, Murray Gell-Mann, Norbert Wiener, Norman Macrae, packet switching, pattern recognition, Paul Erdős, Paul Samuelson, phenotype, planetary scale, RAND corporation, random walk, Richard Feynman, SETI@home, social graph, speech recognition, Thorstein Veblen, Turing complete, Turing machine, Von Neumann architecture
After the Watson-Crick results appeared, Barricelli would refer to strings of DNA as “molecule-shaped numbers,” emphasizing the digital nature of polynucleotide chains. “The distinction between an evolution experiment performed by numbers in a computer or by nucleotides in a chemical laboratory is a rather subtle one,” he observed. Information theorists, including Claude Shannon with his 1940 PhD thesis on “An Algebra for Theoretical Genetics” (which was followed by a year at IAS), had already built a framework into which the double helix neatly fit.13 “Genes are probably much like viruses and phages, except that all the evidence concerning them is indirect, and that we can neither isolate them nor multiply them at will,” von Neumann had written to Norbert Wiener in November 1946, suggesting that one way to find out how nature makes its copies would simply be to look. In December 1946, after consultation with Vladimir Zworykin and Andrew Booth, von Neumann submitted a proposal to determine biomolecular structures by bombarding centimeter-scale models, made out of small metallic spheres, with radar waves.
refers to Walter Pitts and Warren McCulloch’s 1943 results on the powers—including Turing universality—of what we now call neural nets. “J.B., H.H.G.!” refers to Julian Bigelow and Herman H. Goldstine—who rarely agreed on anything, so this may be a reference to early discussions of the powers of arrays of communicating cells, before disagreement about how to implement this in practice intervened. “Double line trick, etc.” is evocative of the double-helix replication of DNA, and “Degeneration (?)” probably refers to how any enduring system of self-reproduction must depend on error-correcting codes in translating from one generation to the next. “Ulam!” probably refers to Ulam’s interest in the powers of Turing-complete cellular automata, now evidenced by many of the computational processes surrounding us today. The triplicate appearance of “Turing!”
Troublemakers: Silicon Valley's Coming of Age by Leslie Berlin
AltaVista, Apple II, Asilomar, Asilomar Conference on Recombinant DNA, beat the dealer, Bill Gates: Altair 8800, Bob Noyce, Byte Shop, Clayton Christensen, cloud computing, computer age, discovery of DNA, don't be evil, Donald Knuth, double helix, Douglas Engelbart, Douglas Engelbart, Dynabook, Edward Thorp, El Camino Real, fear of failure, Fellow of the Royal Society, financial independence, game design, Haight Ashbury, hiring and firing, industrial robot, informal economy, Internet of things, inventory management, John Markoff, Kickstarter, Kitchen Debate, Leonard Kleinrock, manufacturing employment, Mark Zuckerberg, Menlo Park, Minecraft, Mother of all demos, packet switching, Ralph Nader, Robert Metcalfe, rolodex, Ronald Reagan, Sand Hill Road, Silicon Valley, Silicon Valley startup, Snapchat, software as a service, Steve Jobs, Steve Wozniak, Steven Levy, Stewart Brand, Ted Nelson, union organizing, upwardly mobile, William Shockley: the traitorous eight, women in the workforce
Within the company, he knew how to wheedle, badger and cajole the scientific staff, armed with “just enough [science] to be annoying,” as one Genentech researcher put it. Genentech’s scientists hardly lacked motivation, however. Dave Goeddel, who headed the successful push to be the first to make human insulin, liked to say, “You either came in first or you might as well be last.” He designed a T-shirt adorned with the Harley-Davidson logo, a DNA double-helix, and the phrase “Clone or Die.” The road show blur left Swanson “wrung out like a wet dishrag,” in his own description. At day’s end, some of the others repaired to the hotel bar or lobby to sink into the plush seats and enjoy a cigar. But not Swanson. For him, the trip was about much more than bankers and investors and balance sheets. There was someone else along on the road show, someone who did not even work for Genentech.
In the Office of Technology Licensing’s first eighteen months, when only five inventions had been licensed, Reimers reported that “three petitions for title in inventions to sponsors (HEW twice and NSF) were first denied but were eventually granted after much effort including meetings in Washington, D.C. with agency officials”; Licensing Program Progress Report, July 20, 1970, SUOTL. 17. Cohen in “Campus to Commerce: Trailblazers of Technology Transfer,” https://www.youtube.com/watch?v=HA6SYaQ6ZZw. 18. Reimers, ROHO interview. 19. Double Helix Medals Dinner, https://www.youtube.com/watch?v=wTuy4_e9O08. 20. Genentech GenenLab notebook at http://blog.zymergi.com/2013/01/origins-biotech-genentech.html. 21. Boyer’s lab learned that EcoR1 could be used in recombinant DNA after reading Janet E. Mertz and Ronald W. Davis, “Cleavage of DNA by RI Restriction Endonuclease Generates Cohesive Ends,” Proceedings of the National Academy of Sciences, November 1972: 3370–4.
The Moral Animal: Evolutionary Psychology and Everyday Life by Robert Wright
"Robert Solow", agricultural Revolution, Andrei Shleifer, Asian financial crisis, British Empire, centre right, cognitive dissonance, double entry bookkeeping, double helix, fault tolerance, Francis Fukuyama: the end of history, George Gilder, global village, invention of gunpowder, invention of movable type, invention of the telegraph, invention of writing, invisible hand, John Nash: game theory, John von Neumann, Marshall McLuhan, Norbert Wiener, planetary scale, pre–internet, profit motive, Ralph Waldo Emerson, random walk, Richard Thaler, rising living standards, Silicon Valley, social intelligence, social web, Steven Pinker, talking drums, the medium is the message, The Wealth of Nations by Adam Smith, trade route, your tax dollars at work, zero-sum game
By observing each other, and trying to improve on what they see, they’ve collectively turned the first crude, serendipitous creation of air art into an array of diverse memes. Maybe the most amazing meme comes from a dolphin named Tinkerbell. She swims along on a sinuous path, releasing a string of little bubbles, and then, by brushing the bubbles with her dorsal fin, joins them together into a corkscrew pattern—or, as described by researchers, a “helix.” It isn’t a double helix, but the symbolism is fitting enough. For memes—once a species has ascended the co-evolutionary escalator, at least—are true to the spirit of genes. Cultural evolution, like biological evolution, carries life to higher and higher levels of organization. And it does it the same way biological evolution does it: zero-sum dynamics intensify non-zero-sum dynamics; competition between entities encourages integration within them.
Udovitch, Abraham L. (1970) “Commercial Techniques in Early Medieval Islamic Trade,” in D. S. Richards, ed. (1970), Islam and the Trade of Asia. University of Pennsylvania Press. Waldman, Marilyn R. (1989) “The Islamic World,” in Encyclopaedia Britannica, 15th ed., vol. 22. Waldrop, M. Mitchell (1992) Complexity. Simon and Schuster. Waters, Malcolm (1995) Globalization. Routledge. Watson, Adam (1992) The Evolution of International Society. Routledge. Watson, James (1969) The Double Helix. Mentor. Watson, Patty Jo (1995) “Explaining the Transition to Agriculture,” in Price and Gebauer, eds. (1995). Weber, Max (1961) General Economic History. Collier Books. Weinberg, Steven (1979) The First Three Minutes. Bantam. Wenke, Robert J. (1981) “Explaining the Evolution of Cultural Complexity: A Review.” Advances in Archaeological Method and Theory 4:79–127. ——— (1984) Patterns in Prehistory: Humankind’s First Three Million Years.
The Magic of Reality: How We Know What's Really True by Richard Dawkins
Any sufficiently advanced technology is indistinguishable from magic, Buckminster Fuller, double helix, Ernest Rutherford, false memory syndrome, Fellow of the Royal Society, gravity well, if you see hoof prints, think horses—not zebras, Isaac Newton, Johannes Kepler, phenotype, Richard Feynman, the scientific method
Nowadays we know this, and we know exactly how DNA works, thanks to James Watson and Francis Crick, plus a lot of other scientists who came after them. Watson and Crick could not see DNA with their own eyes. Once again, they made their discoveries by imagining models and testing them. In their case, they literally built metal and cardboard models of what DNA might look like, and they calculated what certain measurements ought to be if those models were correct. The predictions of one model, the so-called double helix model, exactly fitted the measurements made by Rosalind Franklin and Maurice Wilkins, using special instruments involving X-rays beamed into crystals of purified DNA. Watson and Crick also immediately realized that their model of the structure of DNA would produce exactly the kind of results seen by Gregor Mendel in his monastery garden. We come to know what is real, then, in one of three ways.
Inequality and the 1% by Danny Dorling
Affordable Care Act / Obamacare, banking crisis, battle of ideas, Bernie Madoff, Big bang: deregulation of the City of London, Boris Johnson, Branko Milanovic, buy and hold, call centre, Capital in the Twenty-First Century by Thomas Piketty, centre right, collective bargaining, conceptual framework, corporate governance, credit crunch, David Attenborough, David Graeber, delayed gratification, Dominic Cummings, double helix, Downton Abbey, en.wikipedia.org, Etonian, family office, financial deregulation, full employment, Gini coefficient, high net worth, housing crisis, income inequality, land value tax, longitudinal study, low skilled workers, lump of labour, mega-rich, Monkeys Reject Unequal Pay, Mont Pelerin Society, mortgage debt, negative equity, Neil Kinnock, Occupy movement, offshore financial centre, plutocrats, Plutocrats, precariat, quantitative easing, race to the bottom, Robert Shiller, Robert Shiller, TaskRabbit, The Spirit Level, The Wealth of Nations by Adam Smith, trickle-down economics, unpaid internship, very high income, We are the 99%, wealth creators, working poor
These are what psychologists call ‘individualistic traits’, rather than the norm of being more pro-social, with positive, helpful and friendly attitudes to other people, not grandiose or conceited. Steve Jones, emeritus professor of genetics at University College London, puts the case against the favoured few succinctly. In chastising Dominic Cummings, he noted: ‘For geneticists, the more we learn about DNA, the more important the environment appears. The lesson from the double helix is that we need more and better teachers, rather than wringing our hands about the unkindness of fate. A few lessons about elementary biology might be a good place to start.’58 We now worry about the extinction of rare species, and the loss of their genes, and see apparent genetic variation within our species as more and more important (see the illustration below). Hereditary rights appear to be back in fashion.
Puzzling People: The Labyrinth of the Psychopath by Thomas Sheridan
They are the grit which causes friction and pain and forces us to take care of ourselves and by extension the ones who really love and care for us in return. They are the ultimate expression of the overall evolutionary process. They are the ‘Missing Link’. Without psychopathic dictators we would not have freedom fighters. Without psychopathic relationships we would not cherish the ones who really care for us. Compassion, empathy and kindness is as much a part of the evolutionary process as the DNA double helix. Mythology is as important as the microscope. Everything counts in order to construct your road map to a safe and secure future where no psychological predators will lie in wait ready to pounce around the next corner. Taking care of oneself first and foremost is not being selfish, unpatriotic or uncaring. It is only when we discard the effect our own personal choices have upon others that it becomes a problem.
The Quantum Curators and the Fabergé Egg: A Fast Paced Portal Adventure by Eva St. John
He paused as we waited for the lights to turn red as we continued towards King’s College. ‘It became a habit during school after that, to shout that we were doing things in honour of those women.’ Charlie smiled nostalgically, then said, ‘Do you know, I had totally forgotten that. One time he led a rugby charge, shouting “For Eleanor and Aquitaine”.’ ‘So, who is Franklin?’ ‘Rosalind Franklin. She was instrumental in discovering the double helix in DNA, but it was two male colleagues, Crick and Watson, that got the Nobel Prize.’ ‘And what does the clue mean? Why is she hungry?’ ‘It’s the chronogram. Its nickname is Rosalind!’ We were now stood by the railings outside of Kings College, and Julius was pointing across the road to some weird-arsed clock that I had seen a few days ago. On the corner of the street, recessed into the wall and behind a large window, was a huge set of golden dials, over a metre wide, ticking and turning like a bizarre clock face.
Cooking for Geeks by Jeff Potter
3D printing, A Pattern Language, carbon footprint, centre right, Community Supported Agriculture, Computer Numeric Control, crowdsourcing, Donald Knuth, double helix, en.wikipedia.org, European colonialism, fear of failure, food miles, functional fixedness, hacker house, haute cuisine, helicopter parent, Internet Archive, iterative process, Kickstarter, Parkinson's law, placebo effect, random walk, Rubik’s Cube, slashdot, stochastic process, the scientific method
When heated above 185°F / 85°C, the galactose in agar melts, and upon cooling below 90–104°F / 32–40°C it forms a double-helix structure. (The exact gelling temperature depends on the concentration of agar.) During gelling, the endpoints of the double helices are able to bond to each other. Agar has a large hysteresis; that is, the temperature at which it converts back to a gel is much lower than the temperature at which that gel melts back to a liquid, which means that you can warm the set gel up to a moderately warm temperature and have it remain solid. For more information on the chemistry of agar, see http://www.cybercolloids.net/library/agar/properties.php. Agar at the molecular level. When heated, the molecule relaxes into a relatively straight molecule (upper left) that upon cooling forms a double helix with another agar molecule (center). The ends of these double helices can bond with other agar double helices (upper right), forming a 3D mesh (left).
Adaptive Markets: Financial Evolution at the Speed of Thought by Andrew W. Lo
"Robert Solow", Albert Einstein, Alfred Russel Wallace, algorithmic trading, Andrei Shleifer, Arthur Eddington, Asian financial crisis, asset allocation, asset-backed security, backtesting, bank run, barriers to entry, Berlin Wall, Bernie Madoff, bitcoin, Bonfire of the Vanities, bonus culture, break the buck, Brownian motion, business cycle, business process, butterfly effect, buy and hold, capital asset pricing model, Captain Sullenberger Hudson, Carmen Reinhart, collapse of Lehman Brothers, collateralized debt obligation, commoditize, computerized trading, corporate governance, creative destruction, Credit Default Swap, credit default swaps / collateralized debt obligations, cryptocurrency, Daniel Kahneman / Amos Tversky, delayed gratification, Diane Coyle, diversification, diversified portfolio, double helix, easy for humans, difficult for computers, Ernest Rutherford, Eugene Fama: efficient market hypothesis, experimental economics, experimental subject, Fall of the Berlin Wall, financial deregulation, financial innovation, financial intermediation, fixed income, Flash crash, Fractional reserve banking, framing effect, Gordon Gekko, greed is good, Hans Rosling, Henri Poincaré, high net worth, housing crisis, incomplete markets, index fund, interest rate derivative, invention of the telegraph, Isaac Newton, James Watt: steam engine, job satisfaction, John Maynard Keynes: Economic Possibilities for our Grandchildren, John Meriwether, Joseph Schumpeter, Kenneth Rogoff, London Interbank Offered Rate, Long Term Capital Management, longitudinal study, loss aversion, Louis Pasteur, mandelbrot fractal, margin call, Mark Zuckerberg, market fundamentalism, martingale, merger arbitrage, meta analysis, meta-analysis, Milgram experiment, money market fund, moral hazard, Myron Scholes, Nick Leeson, old-boy network, out of africa, p-value, paper trading, passive investing, Paul Lévy, Paul Samuelson, Ponzi scheme, predatory finance, prediction markets, price discovery process, profit maximization, profit motive, quantitative hedge fund, quantitative trading / quantitative ﬁnance, RAND corporation, random walk, randomized controlled trial, Renaissance Technologies, Richard Feynman, Richard Feynman: Challenger O-ring, risk tolerance, Robert Shiller, Robert Shiller, Sam Peltzman, Shai Danziger, short selling, sovereign wealth fund, Stanford marshmallow experiment, Stanford prison experiment, statistical arbitrage, Steven Pinker, stochastic process, stocks for the long run, survivorship bias, Thales and the olive presses, The Great Moderation, the scientific method, The Wealth of Nations by Adam Smith, The Wisdom of Crowds, theory of mind, Thomas Malthus, Thorstein Veblen, Tobin tax, too big to fail, transaction costs, Triangle Shirtwaist Factory, ultimatum game, Upton Sinclair, US Airways Flight 1549, Walter Mischel, Watson beat the top human players on Jeopardy!, WikiLeaks, Yogi Berra, zero-sum game
Natural selection is an entirely unplanned process, but it does depend on the range of variation within a species. This variation, in turn, depends on genes. We’ve seen how individuals within a species with more useful genetic traits for their environment are reproductively more successful than individuals with slightly less useful traits, but where do these different traits in a species come from? The answer to this riddle is mutation. Watson and Crick’s famous discovery of the double-helix structure of DNA showed not only how DNA could carry information, but also how it could act as its own template when copying itself. The process of genetic replication is very accurate. However, because of the physical structure of DNA and the laws of thermodynamics, it’s not quite perfect. As a result, entirely new variations in genetic traits occur naturally in an organism’s genome from time to time.
The private sector also pours tens of billions of dollars each year into biomedicine, but the nature of that funding is quite different. Investors demand a rate of return on their capital and won’t fund basic science, since there’s no way to extract a financial return on new knowledge unless it’s patentable or otherwise commercial. Much of basic science, like Watson and Crick’s discovery of the double helix structure of DNA, or the sequencing of the human genome, isn’t patentable, but is enormously valuable in contributing to a multitude of applications that are patentable. As a result, private sector investment in biomedicine waxes and wanes, depending on the perceived risks and rewards of the companies seeking funding. In the late 1990s, biotech companies were hot, in some cases even hotter than the Internet companies that were taking off around the same time.
The Invention of Science: A New History of the Scientific Revolution by David Wootton
agricultural Revolution, Albert Einstein, British Empire, clockwork universe, Commentariolus, commoditize, conceptual framework, Dava Sobel, double entry bookkeeping, double helix, en.wikipedia.org, Ernest Rutherford, Fellow of the Royal Society, fudge factor, germ theory of disease, Google X / Alphabet X, Hans Lippershey, interchangeable parts, invention of gunpowder, invention of the steam engine, invention of the telescope, Isaac Newton, Jacques de Vaucanson, James Watt: steam engine, Johannes Kepler, John Harrison: Longitude, knowledge economy, lateral thinking, lone genius, Mercator projection, On the Revolutions of the Heavenly Spheres, Philip Mirowski, placebo effect, QWERTY keyboard, Republic of Letters, social intelligence, spice trade, spinning jenny, the scientific method, Thomas Kuhn: the structure of scientific revolutions
Steven Weinberg, a Nobel prize-winning physicist, expressed this view when he wrote ‘when we make contact with beings from another planet we will find that they have discovered the same laws of physical science as we have.’33 Science is thus a cross-cultural language which any culture can in principle learn to speak, and which any technologically sophisticated culture will already have learnt to speak. This was the assumption underlying a message that was broadcast into space by the Arecibo radio telescope in 1974. The message consisted of the numbers one through to ten, the atomic numbers of hydrogen, carbon, nitrogen, oxygen and phosphorus, the formulas for the sugars and bases in the nucleotides of DNA, the number of nucleotides in DNA, the double helix structure of DNA, a figure of a human being and its height, the population of Earth, a diagram of our solar system, and an image of the Arecibo telescope with its diameter. The assumption was that any extraterrestrial intelligence capable of receiving the message would recognize the maths and the science and quickly make sense of the Earth-specific information. The great mathematician Christiaan Huygens discovered the law of the pendulum in 1673; he believed that there were inhabited planets scattered across the universe; and by the time he died in 1695 he had persuaded himself that this law was known throughout the universe.34 The opposing view is that science is shaped by a whole series of cultural and social factors which ensure that no two societies would produce the same knowledge, just as no two societies produce the same religious beliefs.
Wind and Water in the Middle Ages: Fluid Technologies from Antiquity to the Renaissance. Tempe, AZ: ACMRS, 2006. Washburn, Wilcomb E. ‘The Meaning of “Discovery” in the Fifteenth and Sixteenth Centuries’. American Historical Review 68 (1962): 1–21. Waters, David W. ‘Nautical Astronomy and the Problem of Longitude’. In The Uses of Science in the Age of Newton. Ed. JG Burke. Berkeley: University of California Press, 1983: 143–69. Watson, James D. The Double Helix: A Personal Account of the Discovery of the Structure of DNA. London: Weidenfeld & Nicolson, 1968. Weber, Eugen. Peasants into Frenchmen: The Modernization of Rural France 1870–1914. Stanford: Stanford University Press, 1976. Weber, Max. The Vocation Lectures. Ed. TB Strong and DS Owen. Trans. R Livingstone. Indianapolis: Hackett, 2004. Webster, Charles. ‘The Discovery of Boyle’s Law, and the Concept of the Elasticity of Air in the Seventeenth Century’.
Waldseemüller is far too good a Latinist to copy Vespucci’s usage in the Cosmographiae introductio. O’Gorman argues that Waldseemüller’s invenio should be translated as ‘conceive’, not ‘discover’, which is to ignore the fact that Waldseemüller is working from a Latin text of Vespucci in which invenio is already a translation of discooperio (O’Gorman, The Invention of America (1961), 123 and n. 117). 8. See, for example, Wolper, ‘The Rhetoric of Gunpowder’ (1970). 9. Watson, The Double Helix (1968), 197. 10. On the discovery of discovery: Fleming (ed.), The Invention of Discovery (2011); and Margolis, It Started with Copernicus (2002), Ch. 3 – neither explores the new terminology. On curiosity: Huff, Intellectual Curiosity and the Scientific Revolution (2011); Harrison, ‘Curiosity, Forbidden Knowledge’ (2001); Ball, Curiosity (2012); Daston, ‘Curiosity in Early Modern Science’ (1995); and Daston & Park, Wonders and the Order of Nature (1998), 303–28.
Whiplash: How to Survive Our Faster Future by Joi Ito, Jeff Howe
3D printing, Albert Michelson, Amazon Web Services, artificial general intelligence, basic income, Bernie Sanders, bitcoin, Black Swan, blockchain, Burning Man, buy low sell high, Claude Shannon: information theory, cloud computing, Computer Numeric Control, conceptual framework, crowdsourcing, cryptocurrency, data acquisition, disruptive innovation, Donald Trump, double helix, Edward Snowden, Elon Musk, Ferguson, Missouri, fiat currency, financial innovation, Flash crash, frictionless, game design, Gerolamo Cardano, informal economy, interchangeable parts, Internet Archive, Internet of things, Isaac Newton, Jeff Bezos, John Harrison: Longitude, Joi Ito, Khan Academy, Kickstarter, Mark Zuckerberg, microbiome, Nate Silver, Network effects, neurotypical, Oculus Rift, pattern recognition, peer-to-peer, pirate software, pre–internet, prisoner's dilemma, Productivity paradox, race to the bottom, RAND corporation, random walk, Ray Kurzweil, Ronald Coase, Ross Ulbricht, Satoshi Nakamoto, self-driving car, SETI@home, side project, Silicon Valley, Silicon Valley startup, Simon Singh, Singularitarianism, Skype, slashdot, smart contracts, Steve Ballmer, Steve Jobs, Steven Levy, Stewart Brand, Stuxnet, supply-chain management, technological singularity, technoutopianism, The Nature of the Firm, the scientific method, The Signal and the Noise by Nate Silver, There's no reason for any individual to have a computer in his home - Ken Olsen, Thomas Kuhn: the structure of scientific revolutions, universal basic income, unpaid internship, uranium enrichment, urban planning, WikiLeaks
A sort of lunar capsule with long spindly legs, it might well haunt your nightmares were it not, in this case, in the employ of the good guys. The European researchers, who call themselves Team Bettencourt after the Paris institution where the project is based, have reprogrammed the phage to do something beneficial. The phage inserts a protein that has been instructed to home in on the genetic mutation that makes the M. tuberculosis strain immune to antibiotics. The protein snips the strands of double helix that bookend the offending sequence, as easily as one of us might delete this sentence after writing it. With this small tweak to the DNA of M. tuberculosis—its source code—the bacterium is again susceptible to a standard drug regime. The Bettencourt group has also demonstrated how they could make a special tissue that can diagnose the disease on the spot, a great advantage in those regions worst affected by tuberculosis outbreaks.
Asymmetry by Lisa Halliday
Where he was from, a boy is superior. A boy is prestige. A boy brings you pride. Where he was from, one might even say: Better an infertile man than a fertile woman. In fact, said the father, I always thought she was a boy. It was a mistake from the beginning. She looks like a boy. She acts like a boy. Her life would be so much easier if she were a boy. He’s a boy. There’s no cure for CAH. It’s a genetic condition whereby the double helix inherits two copies of a faulty gene, one copy from each parent. Usually, the gene is recessive to a dominant counterpart. But if both parents are carriers, there’s a 25 percent chance their child will inherit both faulty genes and express the condition. This leaves a 50 percent chance the child will inherit only one faulty gene (and become another carrier), and a 25 percent chance the child will inherit only normal genes, and be unaffected.
We're Going to Need More Wine: Stories That Are Funny, Complicated, and True by Gabrielle Union
He gave his cousin his wristband. Then I noticed that he was wearing a #22 wristband. When you as a player wear someone else’s jersey number it means one of two things: You are paying tribute to a significant other who plays, or you are honoring a player who died. Now, my number was 21, so I made up this scenario in my head about who #22 could be. My teenage levels of narcissism and drama wrapped in a crazy double helix of denial. I decided Jason had a friend who died. Jason was so sensitive, paying homage to this person via a sweatband. RIP #22, I hardly knew you. During the game, a few of his friends came over to me, led by a female friend of his with a severe case of a Valley Girl accent. “Soooo, are you and Jason going to prom?” she asked. “Yeah,” I answered, innocently. “Uhhhhmmmmm, I might, like, hold off on those plans.”
To Be a Machine: Adventures Among Cyborgs, Utopians, Hackers, and the Futurists Solving the Modest Problem of Death by Mark O'Connell
3D printing, Ada Lovelace, AI winter, Airbnb, Albert Einstein, artificial general intelligence, brain emulation, clean water, cognitive dissonance, computer age, cosmological principle, dark matter, disruptive innovation, double helix, Edward Snowden, effective altruism, Elon Musk, Extropian, friendly AI, global pandemic, impulse control, income inequality, invention of the wheel, Jacques de Vaucanson, John von Neumann, knowledge economy, Law of Accelerating Returns, life extension, lifelogging, Lyft, Mars Rover, means of production, Norbert Wiener, Peter Thiel, profit motive, Ray Kurzweil, RFID, self-driving car, sharing economy, Silicon Valley, Silicon Valley ideology, Singularitarianism, Skype, Stephen Hawking, Steve Wozniak, superintelligent machines, technological singularity, technoutopianism, The Coming Technological Singularity, Travis Kalanick, trickle-down economics, Turing machine, uber lyft, Vernor Vinge
And Tim: given that his whole deal was radical self-transformation, Tim looked very much like a guy who’d worked out an aesthetic for himself at sixteen and basically butched it out since the late 1990s. He wore a black flat cap, a Grindhouse T-shirt, chunky skater shoes, and green cargo shorts that exposed a tattoo on his right calf depicting a cartoon punk (Mohawk, Dead Kennedys shirt) holding a gun to his own head. Another large tattoo, on the pale underside of his left arm, depicted a DNA double helix surrounded by a circular cog. This pictorial representation of Tim’s mechanistic view of Homo sapiens—a grinding of the human code—was, literally, underscored by an impressively lurid scar, gnarled and thick-grained as bark. This was the result of a device called Circadia he’d had implanted for three months of last year; it took various biometric measurements from his body and uploaded them via Bluetooth to his phone, and thereby to the Internet, at five-second intervals—adjusting for good measure the thermostat of his house’s central heating in accordance with his body temperature.
The Half-Life of Facts: Why Everything We Know Has an Expiration Date by Samuel Arbesman
Albert Einstein, Alfred Russel Wallace, Amazon Mechanical Turk, Andrew Wiles, bioinformatics, British Empire, Cesare Marchetti: Marchetti’s constant, Chelsea Manning, Clayton Christensen, cognitive bias, cognitive dissonance, conceptual framework, David Brooks, demographic transition, double entry bookkeeping, double helix, Galaxy Zoo, guest worker program, Gödel, Escher, Bach, Ignaz Semmelweis: hand washing, index fund, invention of movable type, Isaac Newton, John Harrison: Longitude, Kevin Kelly, life extension, Marc Andreessen, meta analysis, meta-analysis, Milgram experiment, Nicholas Carr, P = NP, p-value, Paul Erdős, Pluto: dwarf planet, publication bias, randomized controlled trial, Richard Feynman, Rodney Brooks, scientific worldview, social graph, social web, text mining, the scientific method, Thomas Kuhn: the structure of scientific revolutions, Thomas Malthus, Tyler Cowen: Great Stagnation
These types of errors, which can be used to understand the provenance of a document, are actually nearly identical to the types of errors caused by polymerase enzymes, the proteins responsible for copying DNA strands. When it comes to copying DNA—those strands of information that code for proteins and so much more—there are a few advantages over simply hand copying a document. DNA’s language is made up of four letters, or bases, which come in complementary pairs: A always goes with T, and G always goes with C. When DNA is copied, its double helix is unzipped, and the letters of each helix—one side of the zipper—can be easily paired with their complementary letters. This results in two new double helices—closed zippers—both of which have properly paired letters, because the complementary letters act as a simple way to prevent errors. Nonetheless, when DNA is replicated, it’s sometimes done imperfectly. The group of chemical machines responsible for duplicating a strand of DNA occasionally makes mistakes.
When the Air Hits Your Brain: Tales From Neurosurgery by Frank Vertosick
Underneath their fine incisions Stirs the Culprit—Life! —EMILY DICKINSON Introduction Neurosurgery is an arrogant occupation. Astronomers study the stars but never touch them. Particle physicists see God in the vapor trails of their great atom-smashers, but cannot see the particles themselves, cannot reach into protons and feel the quarks with their fingers. Molecular biologists sing the praises of the double helix, but the gene is forever an abstraction, invisible to the naked eye. These scientists must be content with the shadow nature casts upon their instruments and photographic emulsions. But not the neurosurgeon, for whom the greatest mystery of creation resides in a few pounds of greasy flesh and blood. Only the neurosurgeon dares to improve upon five billion years of evolution in a few hours. The human brain.
Explore Everything by Bradley Garrett
airport security, Burning Man, call centre, creative destruction, deindustrialization, double helix, dumpster diving, failed state, Google Earth, Hacker Ethic, Jane Jacobs, Julian Assange, late capitalism, megacity, New Urbanism, Occupy movement, place-making, shareholder value, the built environment, The Death and Life of Great American Cities, urban planning, white flight, WikiLeaks
.* It’s clear from the reactions of authorities we encountered through our explorations that the ‘problem’ with what explorers do is not that it is illegal but that, in capitalist terms, it’s pointless and therefore highly suspect, or that it embarrasses the forces of security, order and control. However, while neoliberal agents may be confused or frustrated by urban exploration, it is much more a celebration than a condemnation of capital and spectacle. It’s an anti-spectacle that runs alongside the main act, weaving a double helix. Perhaps in the United States people are more understanding of someone having the gall to play by their own rules. Capital investment is the catalyst both for sensibly sterile spaces of economic production and for spatial fluidity (some would say forced mobility), as well as leftover, forgotten and (often unintentionally) disused spaces. Both types of sites are the inevitable result of endless ‘development’ and the inexorable quest to increase profit margins, bottom lines and shareholder value.25 Explorers understand the role monetary investment plays in creating both new constructions and ruins, and, where preceding movements connected to my notion of place hacking might condemn capitalism for creating sterile space and seek to turn streets into battlefields in an effort to overthrow the dominant social order,26 urban explorers celebrate capitalism for both its successes and its failures, rejoicing over the construction of new skyscrapers as well as the economic crises that empty them.
The botany of desire: a plant's-eye view of the world by Michael Pollan
back-to-the-land, clean water, David Attenborough, double entry bookkeeping, double helix, Francisco Pizarro, invention of agriculture, Joseph Schumpeter, mandatory minimum, Maui Hawaii, means of production, paper trading, Ralph Waldo Emerson, Steven Pinker
For reasons not yet understood, the agrobacterium method seems to work best on broadleaf species such as the potato, the gene gun better on grasses, such as corn and wheat. The gene gun is a strangely high-low piece of technology, but the main thing you need to know about it is that the gun here is not a metaphor: a .22 shell is used to fire stainless-steel projectiles dipped in a DNA solution at a stem or leaf of the target plant. If all goes well, some of the DNA will pierce the wall of some of the cells’ nuclei and elbow its way into the double helix: a bully breaking into a line dance. If the new DNA happens to land in the right place—and no one yet knows what, or where, that place is—the plant grown from that cell will express the new gene. That’s it? That’s it. Apart from its slightly more debonair means of entry, the agrobacterium works in much the same way. In the clean rooms, where the air pressure is kept artificially high to prevent errant microbes from wandering in, technicians sit at lab benches before petri dishes in which fingernail-sized sections of potato stem have been placed in a clear nutrient jelly.
Branded Beauty by Mark Tungate
augmented reality, Berlin Wall, call centre, corporate social responsibility, double helix, East Village, Fall of the Berlin Wall, Frank Gehry, haute couture, invention of the printing press, joint-stock company, liberal capitalism, placebo effect, Ray Kurzweil, Silicon Valley, stem cell
It earned a mention in LVMH’s financial results for the first quarter of 2010, which described it as ‘performing well’. WHERE SCIENCE MEETS STATUS The desire to blind consumers with science has led to the equivalent of an arms race in the industry, as each brand attempts to outdo the other with its latest find. They patent their findings and boast about these patents in their advertising claims: for example, Estée Lauder signals ‘20 patents worldwide’ and ‘25 years of DNA research’, emphasized by a golden double helix, for its Advanced Night Repair cream. Since 1991, Chanel has run the Centre de recherches et d’investigations épidermiques et sensorielles (epidermal and sensory research and investigation centre) (CERIES), which grants a €40,000 annual award for ground-breaking research into skincare. One of Chanel’s weapons in the skincare wars is Xavier Ormancey, the brand’s director of active ingredient research.
Toast by Stross, Charles
anthropic principle, Buckminster Fuller, cosmological principle, dark matter, double helix, Ernest Rutherford, Extropian, Francis Fukuyama: the end of history, glass ceiling, gravity well, Khyber Pass, Mars Rover, Mikhail Gorbachev, NP-complete, oil shale / tar sands, peak oil, performance metric, phenotype, plutocrats, Plutocrats, Ronald Reagan, Silicon Valley, slashdot, speech recognition, strong AI, traveling salesman, Turing test, urban renewal, Vernor Vinge, Whole Earth Review, Y2K
Wright vanished for three years; it was not until a fateful day in August of 1945 that we discovered the ends to which his research into explosive lenses had been put. Sadly, Kotcha the Albanian proved to be unreliable. He returned to his homeland and was immediately spirited away to the Soviet Union, taking his work on ultracentrifugation with him. We cannot estimate the extent of his contribution to the Bolshevik bomb program at this time. Meanwhile, work continues apace. The discovery of the Double Helix has given a tremendous boost to the Botanical Committee, who are now making extensive use of the Boddington’s Mark One Computer that now occupies the cellar of our former premises in Greek Street. When not employed preparing the accounts for the Boddington’s Beverage Corporation, the computer is used to assist the X-ray crystallographic analysis of the enzymes responsible for the production of the alkaloid constituents of Coffee.
Mind Wide Open: Your Brain and the Neuroscience of Everyday Life by Steven Johnson
Columbine, double helix, epigenetics, experimental subject, Gödel, Escher, Bach, James Watt: steam engine, l'esprit de l'escalier, lateral thinking, pattern recognition, phenotype, social intelligence, Steven Pinker, theory of mind, zero-sum game
Even the most dogged biological determinist wouldn’t argue that people with innately lower cortisol levels were naturally rising to the top of the heap. Clearly the cultural environment of the civil service was affecting the stress levels of its members, and changing their brain chemistry accordingly. More status, less cortisol; less status, more cortisol. Such hormone levels would appear on one of our imagined neurotransmitter profiles, but they wouldn’t necessarily suggest some fate sealed in the double helix before birth. In fact, they might well point to an imbalance outside the individual body, in society itself. The drugs flowing through our bodies and our brains can tell us a great deal about ourselves, but not just the biological selves we were born with. They are also symptoms of a wider world outside the brain, a world that the brain’s inner chemistry reflects. I suspect that not too long from now we’ll see charts of average cortisol levels-alongside those of the other major endogenous drugs-across national populations, tracked over long periods of time.
The New Rules of War: Victory in the Age of Durable Disorder by Sean McFate
active measures, anti-communist, barriers to entry, Berlin Wall, blood diamonds, cognitive dissonance, commoditize, computer vision, corporate governance, corporate raider, cuban missile crisis, Donald Trump, double helix, drone strike, European colonialism, failed state, hive mind, index fund, invisible hand, John Markoff, joint-stock company, moral hazard, mutually assured destruction, Nash equilibrium, offshore financial centre, pattern recognition, Peace of Westphalia, plutocrats, Plutocrats, private military company, profit motive, RAND corporation, ransomware, Ronald Reagan, Silicon Valley, South China Sea, Stuxnet, technoutopianism, Washington Consensus, Westphalian system, yellow journalism, Yom Kippur War, zero day, zero-sum game
The landmark 2010 Supreme Court case Citizens United v. Federal Election Commission reversed decades of understanding by deeming corporate political contributions the same thing as individuals’ free speech. However, no reasonable person would agree that a corporation, with its vast resources and single-minded agenda, is remotely the same thing as an individual person. Corporations are not people. But the double helix of corporations and politicos forms the DNA of America’s power structure. Deep states exist, and their naked power will become more apparent as states fade. Their unmasking will prove dangerous, as the protestors of the Arab Spring discovered. When a deep state is threatened, it does not go gentle into that good night. It attacks. It is one of the forces accelerating durable disorder, and through it other powerful countries will go the way of Iran, Turkey, Egypt, China, and Russia in the future.
The Strange Order of Things: The Biological Roots of Culture by Antonio Damasio
Albert Einstein, biofilm, business process, Daniel Kahneman / Amos Tversky, double helix, Gordon Gekko, invention of the wheel, invention of writing, invisible hand, job automation, mental accounting, meta analysis, meta-analysis, microbiome, Norbert Wiener, pattern recognition, Peter Singer: altruism, planetary scale, profit motive, Ray Kurzweil, Richard Feynman, self-driving car, Silicon Valley, Steven Pinker, Thomas Malthus
At first blush, in the wake of the discovery of the structure of DNA, the elucidation of the role of RNA, and the breaking of the genetic code, it must have appeared that life had to come from the genetic material, but that idea was up against a major difficulty: the likelihood of such complex molecules assembling themselves spontaneously as the first step in the construction of life was low to nil.6 The puzzlement and equivocation were perfectly understandable. The 1953 discovery (by Francis Crick and James Watson and Rosalind Franklin) of the double-helix structure of DNA was and remains one of the peak moments of the history of science and deservedly influenced the formulations of life that followed. DNA was inevitably seen as the molecule of life and, by extension, the molecule of its beginning. But how could a molecule so complex put itself together spontaneously in the primordial soup? Seen from that perspective, the likelihood of life’s spontaneous emergence was so negligible that it justified Francis Crick’s skepticism that it would have originated on Earth.
QI: The Third Book of General Ignorance (Qi: Book of General Ignorance) by John Lloyd, John Mitchinson
Albert Einstein, Boris Johnson, British Empire, California gold rush, cognitive dissonance, dark matter, double helix, epigenetics, Johann Wolfgang von Goethe, Johannes Kepler, Kickstarter, music of the spheres, Nelson Mandela, out of africa, Ronald Reagan, The Wisdom of Crowds, trade route
He did wonder if nuclein might be involved in heredity, but soon discounted it. He couldn’t believe a single molecule could account for all the variation seen within species. It was more than 60 years before anyone proved DNA communicated genetic information, and 25 more before Crick and Watson won the 1962 Nobel Prize in Physiology or Medicine for identifying the shape of its molecule. They discovered DNA is double-helix-shaped, like two interlocking spiral staircases. Rosalind Franklin, who produced the first images of DNA, was supposedly snubbed by the Nobel Prize Committee when they awarded the prize to Crick and Watson in 1962. In fact, Franklin died of cancer in 1958 and was ineligible for the prize, which is never given posthumously. It was shared by Crick and Watson – and Maurice Wilkins, who’d worked with Franklin on the images.
The Mind Is Flat: The Illusion of Mental Depth and the Improvised Mind by Nick Chater
After thirty years working with computational and mathematical models of the mind, and surveying and gathering experimental data, I have come to accept that our intuitive conceptions of our own minds, and many of our scientific theories of the mind that have been built upon that conception, are fundamentally flawed. From a broader perspective, perhaps this should not surprise us. The entire history of science has been a tale of one astonishing shock after another: that the Earth goes around the sun; that the chemical elements of which it was composed were expelled from dying stars; that matter can turn into energy; that life is encoded in a double helix of chemicals; and that our distant ancestors were single-celled organisms. The very idea that thought is the product of a whirr of electrical and chemical activity across a hundred billion nerve cells is remarkable enough. Indeed, in this book I will argue that almost everything we think we know about the operation of our own minds – our intuitive introspections, justifications and explanations – needs to be abandoned wholesale.
The Doomsday Calculation: How an Equation That Predicts the Future Is Transforming Everything We Know About Life and the Universe by William Poundstone
Albert Einstein, anthropic principle, Any sufficiently advanced technology is indistinguishable from magic, Arthur Eddington, Bayesian statistics, Benoit Mandelbrot, Berlin Wall, bitcoin, Black Swan, conceptual framework, cosmic microwave background, cosmological constant, cosmological principle, cuban missile crisis, dark matter, digital map, discounted cash flows, Donald Trump, Doomsday Clock, double helix, Elon Musk, Gerolamo Cardano, index fund, Isaac Newton, Jaron Lanier, Jeff Bezos, John Markoff, John von Neumann, mandelbrot fractal, Mark Zuckerberg, Mars Rover, Peter Thiel, Pierre-Simon Laplace, probability theory / Blaise Pascal / Pierre de Fermat, RAND corporation, random walk, Richard Feynman, ride hailing / ride sharing, Rodney Brooks, Ronald Reagan, Ronald Reagan: Tear down this wall, Sam Altman, Schrödinger's Cat, Search for Extraterrestrial Intelligence, self-driving car, Silicon Valley, Skype, Stanislav Petrov, Stephen Hawking, strong AI, Thomas Bayes, Thomas Malthus, time value of money, Turing test
Fermi’s question remains as great a mystery as ever. Nick Bostrom painted this word picture: life on Earth is a single data point, and the Fermi paradox is the question mark over it. The Princess in the Tower In 1971 Byurakan, Armenia, hosted a conference on extraterrestrial life that is remembered for a confrontation between celebrity astronomer Carl Sagan and biochemist Francis Crick, codiscoverer of the double helix. Their dispute was over a simple question: How likely had it been for intelligent life to arise on Earth? The absence of evidence for ETs had only made Sagan’s heart grow fonder. He was building a career as a cheerleader for the existence of extraterrestrial life. Sagan’s position was that the Earth is a typical planet, as far as we can tell. Intelligent life evolved here. That’s a one-for-one batting average for intelligent life.
From Gutenberg to Google: electronic representations of literary texts by Peter L. Shillingsburg
British Empire, computer age, double helix, HyperCard, hypertext link, interchangeable parts, invention of the telephone, means of production, optical character recognition, pattern recognition, Saturday Night Live, Socratic dialogue
I choose the problematic word ‘‘aesthetics’’ in part to honor the bold use of it made by my colleague, a modernist and Yeats editor, David Holdeman in a paper titled ‘‘The Editor as Artist.’’ His choice struck a chord with me that is worth plucking again.8 Aesthetics and beauty have not been fashionable words for use with science or scholarship, though I still remember the shock of recognition that I felt when reading in James Watson’s Double Helix that he knew he had the right model for DNA because it was beautiful. Aesthetics has many definitions, but among them are the notions that what may seem to be multifarious may also be seen as unity, that the chaotic can have harmony, that the complex may have coherence, that the intricate can have pattern, that the disparate may have commonality. Out of the many, one: e pluribus unum – . We abandoned these notions when we recognized that the pursuit of Truth and Wholeness with capital letters represented a misguided combination of idealism and essentialism.
The Fractalist by Benoit Mandelbrot
Albert Einstein, Benoit Mandelbrot, Brownian motion, business cycle, Claude Shannon: information theory, discrete time, double helix, Georg Cantor, Henri Poincaré, Honoré de Balzac, illegal immigration, Isaac Newton, iterative process, Johannes Kepler, John von Neumann, linear programming, Louis Bachelier, Louis Blériot, Louis Pasteur, mandelbrot fractal, New Journalism, Norbert Wiener, Olbers’ paradox, Paul Lévy, Richard Feynman, statistical model, urban renewal, Vilfredo Pareto
Then and there, despite the reservations and declared hostility of several well-established guilds, Delbrück was orchestrating the birth of a new way of being a biologist. At Caltech at that time, the word “biophysics” was forbidden. But soon their work would become “molecular biology.” And in 1952 this field would come to be known universally, in response to the discovery of that icon of natural geometry—the double helix of DNA. Eventually, molecular biology merged with biochemistry, and genomics took it to an industrial stage. Today’s practitioners complain of it being viewed as a mature field. But in 1949, nothing was further removed from the slow-moving maturity of fluid mechanics. A high Prussian aristocrat—a Junker—Delbrück had to leave Germany because he would not swear allegiance to Hitler. One of the would-be assassins of the Führer was a cousin of his.
Massive: The Missing Particle That Sparked the Greatest Hunt in Science by Ian Sample
Albert Einstein, Arthur Eddington, cuban missile crisis, dark matter, Donald Trump, double helix, Ernest Rutherford, Gary Taubes, Isaac Newton, Johannes Kepler, John Conway, John von Neumann, Kickstarter, Menlo Park, Murray Gell-Mann, Richard Feynman, Ronald Reagan, Stephen Hawking, uranium enrichment, Yogi Berra
Here’s why: synthetic sugar contains equal amounts of left-handed and right-handed sugar molecules. The two kinds are chemically identical, but mirror images of one another. In nature, for reasons unknown, sugar molecules only come in the right-handed variety, the only kind that bacteria will eat. If the bacteria encounter left-handed sugar, they leave it alone. They don’t know how to use it. Handedness is literally built into our genes. The double helix of our DNA is right-handed, as are the amino acids that make it up. The origin of this handedness in nature is one of the most baffling puzzles in biology. In 1984, Stephen Mason, a chemist at King’s College London, found what might be the answer. Particles such as electrons and quarks have a property called “spin” that can be left- or right-handed. The force transmitted by Z particles only affects particles with a left-handed spin.
The Ghost Map: A Street, an Epidemic and the Hidden Power of Urban Networks. by Steven Johnson
call centre, clean water, correlation does not imply causation, creative destruction, Dean Kamen, digital map, double helix, edge city, germ theory of disease, global pandemic, Google Earth, Jane Jacobs, John Nash: game theory, John Snow's cholera map, lone genius, Louis Pasteur, mass immigration, megacity, mutually assured destruction, New Urbanism, nuclear winter, pattern recognition, peak oil, side project, Steven Pinker, Stewart Brand, The Death and Life of Great American Cities, the scientific method, trade route, unbiased observer, working poor
But at a certain point—perhaps ten years from now, perhaps fifty—the window may well close, and the threat may subside, just as other, more specific, biological threats have subsided in the past: polio, smallpox, chicken pox. If this scenario comes to pass, the pandemic threat will ultimately be defeated by a different kind of map—not maps of lives and deaths on a city street, or bird flu outbreaks, but maps of nucleotides wrapped in a double helix. Our ability to analyze the genetic composition of any life-form has made astonishing progress over the past ten years, but in many ways we are at the very beginning of the genomic revolution. We have already seen amazing advances in our understanding of the way genes build organisms, but the application of that understanding—particularly in the realm of medicine—is only starting to bear fruit.
Overdiagnosed: Making People Sick in the Pursuit of Health by H. Gilbert Welch, Lisa M. Schwartz, Steven Woloshin
23andMe, double helix, Google Earth, invisible hand, life extension, longitudinal study, mandelbrot fractal, medical residency, meta analysis, meta-analysis, phenotype, placebo effect, randomized controlled trial, Ronald Reagan, The Wealth of Nations by Adam Smith
In high school, I enjoyed calculating the probabilities of various genotypes using the simple genetics Gregor Mendel discovered cultivating pea plants. In college, I was fascinated to learn how the selective pressures exerted by one very common infectious disease (malaria) actually favored the persistence of particular genetic diseases in human populations (sickle cell disease, glucose-6-phosphate dehydrogenase deficiency). And in medical school, I was intrigued by the mechanics of DNA: how the double helix is replicated, how it gets transcribed into RNA to make proteins, how it gets recombined so we can pass on some of our mothers and some of our fathers to our children, and how it can get usurped by other life forms (viruses) so that our cells work for them.1 Genetics is a wonderful mix of mathematics, evolutionary biology, and biochemistry. It’s good stuff. But I am much less enamored of the idea of testing healthy people’s genes.
Alchemy: The Dark Art and Curious Science of Creating Magic in Brands, Business, and Life by Rory Sutherland
3D printing, Alfred Russel Wallace, barriers to entry, basic income, Black Swan, butterfly effect, California gold rush, call centre, Captain Sullenberger Hudson, Cass Sunstein, cognitive dissonance, Daniel Kahneman / Amos Tversky, Dava Sobel, delayed gratification, Donald Trump, double helix, Downton Abbey, Elon Musk, Firefox, George Akerlof, gig economy, Google Chrome, Google X / Alphabet X, Grace Hopper, Hyperloop, Ignaz Semmelweis: hand washing, IKEA effect, information asymmetry, James Dyson, John Harrison: Longitude, loss aversion, low cost airline, Mason jar, Murray Gell-Mann, Peter Thiel, placebo effect, race to the bottom, Richard Feynman, Richard Thaler, Rory Sutherland, shareholder value, Silicon Valley, social intelligence, Steve Jobs, supply-chain management, the map is not the territory, The Market for Lemons, The Wealth of Nations by Adam Smith, ultimatum game, universal basic income, Upton Sinclair, US Airways Flight 1549, Veblen good
*An extreme example of this is often found in car-park design, where up and down ramps are placed at 90 degrees to the direction of travel of your car, to minimise the amount of concrete needed, even though this requires people repeatedly to execute a difficult manoeuvre with a high chance of damage to their vehicle. By contrast, if you want to see the work of the Steve Jobs of car park design, visit Bloomsbury Square in London, where the underground car park is a double-helix shape; it is possible to go all the way to the bottom and back up again with your steering wheel in one position. *Strictly speaking these radios were not pocket-sized, but in an early manifestation of his genius, Morita ordered shirts with outsized pockets for his employees. If you can’t make the radio smaller, make the pocket larger. *I can also remember seeing my first jogger in the 1970s – I assumed for a moment that he was being pursued by some unseen assailant.
Everything's Trash, but It's Okay by Phoebe Robinson
23andMe, Airbnb, Bernie Madoff, Bernie Sanders, crack epidemic, Donald Trump, double helix, Downton Abbey, Elon Musk, feminist movement, Firefox, Lyft, Mahatma Gandhi, Mark Zuckerberg, Rosa Parks, Silicon Valley, Silicon Valley startup, Tim Cook: Apple, uber lyft
Peep the stats: (1) I’m alive, which means I’ve had enough experience dealing with the good, the bad, and the ugly to know what sucks and what doesn’t, (2) I’ve watched one and a half seasons of Friday Night Lights, so I understand what it takes to lead and assess a situation in mere seconds: wear khakis, always be hot like Kyle Chandler is, and have some hella emotional music cued up when saying something poignant, and (3) sometimes when I give friends advice, I end it with, “but IDK tho,” so that way if my advice Hindenburgs their lives, I can point to the “but IDK tho” clause so they can’t cuss me out completely. You know the saying “Those who can’t do, teach?” Well, in my case, there’s the following saying: “Those who identify trash can do so because the double helixes of their DNA are made out of the plastic rings that keep together a six-pack of Fanta.” My résumé may be a tad iffy; however, I don’t need a PhD to properly analyze the moments that make up our lives. For example, having to do a number two after showering? Trash. Finding an outlet in a store while running errands so you can charge your phone for ten minutes? Non-trash. The fact that Maxine Waters probably put her 1991 game of spades with Ruby Dee, Cicely Tyson, and Alfre Woodard on permanent hold to become a US representative for California?
Foolproof: Why Safety Can Be Dangerous and How Danger Makes Us Safe by Greg Ip
Affordable Care Act / Obamacare, Air France Flight 447, air freight, airport security, Asian financial crisis, asset-backed security, bank run, banking crisis, break the buck, Bretton Woods, business cycle, capital controls, central bank independence, cloud computing, collateralized debt obligation, credit crunch, Credit Default Swap, credit default swaps / collateralized debt obligations, currency peg, Daniel Kahneman / Amos Tversky, diversified portfolio, double helix, endowment effect, Exxon Valdez, financial deregulation, financial innovation, Financial Instability Hypothesis, floating exchange rates, full employment, global supply chain, hindsight bias, Hyman Minsky, Joseph Schumpeter, Kenneth Rogoff, lateral thinking, London Whale, Long Term Capital Management, market bubble, money market fund, moral hazard, Myron Scholes, Network effects, new economy, offshore financial centre, paradox of thrift, pets.com, Ponzi scheme, quantitative easing, Ralph Nader, Richard Thaler, risk tolerance, Ronald Reagan, Sam Peltzman, savings glut, technology bubble, The Great Moderation, too big to fail, transaction costs, union organizing, Unsafe at Any Speed, value at risk, William Langewiesche, zero-sum game
In 1945 Fleming warned that resistant strains would become much more prevalent if penicillin became available in a pill, allowing patients to self-medicate rather than receive the drug intravenously in a hospital. Though Fleming was right about the possibility of resistance, he underestimated its potency. Fleming assumed that resistance would develop through natural selection. Suppose a strain of bacteria contained a mutation on its chromosome—the “double helix” of DNA that acts as a blueprint for the entire organism—that made it resistant to penicillin. Treating the patient with penicillin would kill off all the microbes except the resistant strain, enabling it to thrive and spread. Imagine a change in climate that kills all of a species of rabbit except some with unusually thick fur; the thick-furred species would thereafter become dominant because it was better adapted to this new climate.
The Impulse Society: America in the Age of Instant Gratification by Paul Roberts
2013 Report for America's Infrastructure - American Society of Civil Engineers - 19 March 2013, 3D printing, accounting loophole / creative accounting, activist fund / activist shareholder / activist investor, Affordable Care Act / Obamacare, American Society of Civil Engineers: Report Card, asset allocation, business cycle, business process, Cass Sunstein, centre right, choice architecture, collateralized debt obligation, collective bargaining, computerized trading, corporate governance, corporate raider, corporate social responsibility, creative destruction, crony capitalism, David Brooks, delayed gratification, disruptive innovation, double helix, factory automation, financial deregulation, financial innovation, fixed income, full employment, game design, greed is good, If something cannot go on forever, it will stop - Herbert Stein's Law, impulse control, income inequality, inflation targeting, invisible hand, job automation, John Markoff, Joseph Schumpeter, knowledge worker, late fees, Long Term Capital Management, loss aversion, low skilled workers, mass immigration, new economy, Nicholas Carr, obamacare, Occupy movement, oil shale / tar sands, performance metric, postindustrial economy, profit maximization, Report Card for America’s Infrastructure, reshoring, Richard Thaler, rising living standards, Robert Shiller, Robert Shiller, Rodney Brooks, Ronald Reagan, shareholder value, Silicon Valley, speech recognition, Steve Jobs, technoutopianism, the built environment, The Predators' Ball, the scientific method, The Wealth of Nations by Adam Smith, Thorstein Veblen, too big to fail, total factor productivity, Tyler Cowen: Great Stagnation, Walter Mischel, winner-take-all economy
Shareholder returns (that is, share price appreciation plus dividends)‡ for the five hundred companies on the Standard & Poor’s 500 were more than twice the level of the 1960s and nearly as high as the boom times of the 1950s.6 With each quarterly report, the shareholder revolution and the logic of efficient markets were looking more and more righteous—so much so that many firms granted senior managers steadily larger blocks of company stock in order to “incentivize” them to create even more value. By then, rapid increases in computing power had unleashed the Internet and the surge in technology stocks. For many experts, the dot-com boom was final confirmation of a new economic order, a double helix of digital power and market efficiency that, in theory, was capable of generating even more wealth than the postwar economy. America was back on top. What was becoming clear, however, was that this massive new prosperity wasn’t anywhere near as broadly shared as its postwar predecessor had been—and this was hardly accidental. No longer hobbled by government intervention or expectations of social duties, American businesses were free to focus on a much more efficient and narrowly defined prosperity—one that gratified the interests of shareholders and executives, but left other parties to fend largely for themselves.
Drugs 2.0: The Web Revolution That's Changing How the World Gets High by Mike Power
air freight, Alexander Shulgin, banking crisis, bitcoin, blockchain, Buckminster Fuller, Burning Man, cloud computing, credit crunch, crowdsourcing, death of newspapers, Donald Davies, double helix, Douglas Engelbart, Electric Kool-Aid Acid Test, fiat currency, Firefox, Fractional reserve banking, frictionless, Haight Ashbury, John Bercow, John Markoff, Kevin Kelly, Leonard Kleinrock, means of production, Menlo Park, moral panic, Mother of all demos, Network effects, nuclear paranoia, packet switching, pattern recognition, PIHKAL and TIHKAL, pre–internet, QR code, RAND corporation, Satoshi Nakamoto, selective serotonin reuptake inhibitor (SSRI), sexual politics, Skype, Stephen Hawking, Steve Jobs, Stewart Brand, trade route, Whole Earth Catalog, Zimmermann PGP
The fact that this outlandish mental expedition was embarked upon by a distinguished British politician and an internationally respected scientist reveals much about the journey away from a more liberal British stance towards the dysfunctional model of drug prohibition that now prevails worldwide. LSD remained legal for more than twenty years after its creation, since its users tended to be psychiatrists, scientists and, in the main, other serious-minded researchers. LSD’s early users included James D. Watson and Francis Crick, who cracked the fundamental secret of life in March 1953 when they imagined the double helix form of DNA while under the influence of a small dose of the drug, have shaped society in ways unimaginable before its appearance. Once it escaped the psychiatry ward and other medical institutions in the 1940s and 1950s, LSD was the first compound to enable mass drug use in the West during the 1960s. The mescaline eaten by Ellis was organic, natural and derived from peyote. Huxley, Osmond and Mayhew’s hydrochloride was lab-made, but synthetic – and the dose was 400 mg.
The Big Ratchet: How Humanity Thrives in the Face of Natural Crisis by Ruth Defries
agricultural Revolution, Columbian Exchange, demographic transition, double helix, European colonialism, food miles, Francisco Pizarro, Haber-Bosch Process, Intergovernmental Panel on Climate Change (IPCC), Internet Archive, John Snow's cholera map, out of africa, planetary scale, premature optimization, profit motive, Ralph Waldo Emerson, social intelligence, Thomas Malthus, trade route, transatlantic slave trade
Dwarf varieties kept wheat and rice upright when chemical fertilizers and irrigation boosted the weight. The Green Revolution took genetic twists of nature to new heights, with skyrocketing yields in the developing world that even outstripped the explosive growth in population of the past century. The next pivot is playing out in contemporary times. What Mendel’s experiments did for hybrids, the Nobel Prize–winning 1953 discovery of the double-helix DNA molecule by James Watson, Francis Crick, Maurice Wilkins, and Rosalind Franklin, did for a new frontier for manipulating genes. DNA holds the blueprint for all traits, the code for all life. Breeding plants not by how they look to the eye but by the composition of their DNA, and splicing genes from one species to another, is a far cry from the forager who picked a wild tomato. But the basic principle remains the same.
Bricks & Mortals: Ten Great Buildings and the People They Made by Tom Wilkinson
Berlin Wall, British Empire, cuban missile crisis, Donald Trump, double helix, experimental subject, false memory syndrome, financial independence, Ford paid five dollars a day, Frederick Winslow Taylor, Google Glasses, housing crisis, Kitchen Debate, Mahatma Gandhi, mass incarceration, megacity, neoliberal agenda, New Urbanism, Panopticon Jeremy Bentham, starchitect, traveling salesman, trickle-down economics, Upton Sinclair, urban planning
This advertised the collective spirit of the group, which rejected the existing feudal structure of the profession, in which teams of anonymous office juniors laboured to create projects which would be signed off by a big-name architect, a situation that persists today. In the straitened circumstances of the Depression there were not many opportunities for such a radical group, but they made their mark in 1934 with the unlikeliest of commissions, a penguin pool at London Zoo. The famous double-helix ramp, made possible by the engineering expertise of Ove Arup – who was to collaborate with Tecton and Lubetkin for many years – was an early iteration of one of Lubetkin’s central ideas, the social condenser. Originated by the constructivists, the social condenser was a building that brought people together in new relationships, making new ways of life possible. Bringing penguins together might seem to be somewhat lacking in revolutionary potential, but this was design as propaganda: it was meant to advertise Tecton’s skill and the playful utopian potential of modern architecture to the public at large – and to potential patrons.
This Is Your Country on Drugs: The Secret History of Getting High in America by Ryan Grim
airport security, Alexander Shulgin, anti-communist, back-to-the-land, Burning Man, crack epidemic, double helix, Douglas Engelbart, Douglas Engelbart, East Village, failed state, global supply chain, Haight Ashbury, illegal immigration, John Markoff, Kickstarter, longitudinal study, mandatory minimum, new economy, New Urbanism, PIHKAL and TIHKAL, RAND corporation, Ronald Reagan, Saturday Night Live, Steve Jobs, trade route, transatlantic slave trade, union organizing, Upton Sinclair, upwardly mobile, urban decay, women in the workforce
And perhaps in other scientific areas, too. According to Gilmore, the maverick surfer/chemist Kary Mullis, a well-known LSD enthusiast, told him that acid helped him develop the polymerase chain reaction, a crucial breakthrough for biochemistry. The advance won him the Nobel Prize in 1993. And according to reporter Alun Reese, Francis Crick, who discovered DNA along with James Watson, told friends that he first saw the double-helix structure while tripping on LSD. It’s no secret that Crick took acid; he also publicly advocated the legalization of marijuana. Reese, who reported the story for a British wire service after Crick’s death, said that when he spoke with Crick about what he’d heard from the scientist’s friends, he “listened with rapt, amused attention” and “gave no intimation of surprise. When I had finished, he said, ‘Print a word of it and I’ ll sue.’”
The Vanishing Neighbor: The Transformation of American Community by Marc J. Dunkelman
Affordable Care Act / Obamacare, Albert Einstein, assortative mating, Berlin Wall, big-box store, blue-collar work, Bretton Woods, Broken windows theory, business cycle, call centre, clean water, cuban missile crisis, dark matter, David Brooks, delayed gratification, different worldview, double helix, Downton Abbey, Fall of the Berlin Wall, Filter Bubble, Francis Fukuyama: the end of history, George Santayana, Gini coefficient, glass ceiling, global supply chain, global village, helicopter parent, if you build it, they will come, impulse control, income inequality, invention of movable type, Jane Jacobs, Khyber Pass, Louis Pasteur, Marshall McLuhan, McMansion, Nate Silver, obamacare, Occupy movement, Peter Thiel, post-industrial society, Richard Florida, rolodex, Saturday Night Live, Silicon Valley, Skype, social intelligence, Stanford marshmallow experiment, Steve Jobs, telemarketer, The Chicago School, The Death and Life of Great American Cities, the medium is the message, Tyler Cowen: Great Stagnation, urban decay, urban planning, Walter Mischel, War on Poverty, women in the workforce, World Values Survey, zero-sum game
While their counterparts were boring down more heavily into their respective fields of expertise, Watson and Crick were batting different concepts back and forth across a wider range of subjects. They pondered how the individual nucleic acids bonded. How were they sequenced? Slowly, by splicing the information available to them—much of it garnered from evidence published by their competition—their conversations led them to decipher the code: genes were structured in a double helix, a biological language now known as DNA. Watson and Crick’s triumph illustrates the underlying foundation of creative thinking. Trapped in their own intellectual stovepipes, the world’s leading biochemists, physical chemists, and biophysicists had been unable to fit the individual pieces of evidence together into a comprehensible whole. The breadth of Watson and Crick’s exposure rather than the depth of their expertise propelled them to victory.
Duped: Double Lives, False Identities, and the Con Man I Almost Married by Abby Ellin
Bernie Madoff, bitcoin, Burning Man, business intelligence, Charles Lindbergh, cognitive dissonance, Donald Trump, double helix, dumpster diving, East Village, feminist movement, forensic accounting, fudge factor, hiring and firing, Internet Archive, longitudinal study, Lyft, mandatory minimum, meta analysis, meta-analysis, pink-collar, Ponzi scheme, Robert Hanssen: Double agent, Ronald Reagan, Silicon Valley, Skype, Snapchat, telemarketer, theory of mind, Thomas Kuhn: the structure of scientific revolutions
Equity is built into the way humans interact with each other.”7 Even if we’re not looking for goodness in other people, trust is useful. “Think about how much of what we know has to be accepted on faith rather than through independent observation,” said Vikram Jaswal, an associate professor of psychology at the University of Virginia. “This is particularly clear in science: How many of us can actually demonstrate that the earth is round or that the structure of DNA is a double helix? So our receptiveness to information other people provide, even some things that on the face of it seem outlandish, can serve us well.”8 Taking this pragmatic line of thinking further, there are evolutionary explanations for why we trust. We’re wired to believe that people are inherently good, primarily because society couldn’t function without that default. If we all operated in isolation, we would achieve very little, as individuals and as a species.
Green Mars by Kim Stanley Robinson
It’s trouble for all of us, really.” “Tell me about it. I broke my forearm swinging a tennis racket.” “Left-handed giant bird-people, that’s what we’re growing down here. It’s bizarre, if you ask me. You see them running across the dunes and expect them to just take off and fly.” That night Nirgal had the usual trouble sleeping. Ectogenes, transgenic . . . it made him feel odd. White and green in their double helix. . . . For hours he tossed, wondering what the uneasiness twisting through him meant, wondering what he should feel. Finally, exhausted, he fell asleep. And in his sleep he had a dream. All his dreams before that night had been about Zygote, but now he dreamed that he flew in the air, over the surface of Mars. Vast red canyons cut the land, and volcanoes reared nearly to his unimaginable height.
Very neat, Art thought as he watched a little robot car roll past him in the opposite direction, up the tracks toward the city. The little train car was black, squat, powered by a simple motor engaging the cog track, filled with a cargo that was no doubt mostly carbon nanotube filaments, and capped on top by a big rectangular block of diamond. Art had heard about this in Sheffield, and so was not surprised to see it. The diamond had been salvaged from the double helixes strengthening the cable, and the blocks were actually much less valuable than the carbon filament stored underneath them— basically a kind of fancy hatch door. But they did look nice. On the second day of his drive, Art got off the immense cone of Pavonis, and onto the Tharsis bulge proper. Here the ground was much more littered than the volcano’s side had been with loose rock, and meteor craters.
The Rise and Fall of the British Nation: A Twentieth-Century History by David Edgerton
active measures, Berlin Wall, Big bang: deregulation of the City of London, blue-collar work, British Empire, business cycle, call centre, centre right, collective bargaining, colonial exploitation, Corn Laws, corporate governance, deglobalization, deindustrialization, dematerialisation, deskilling, Donald Davies, double helix, endogenous growth, Etonian, European colonialism, feminist movement, first-past-the-post, full employment, imperial preference, James Dyson, knowledge economy, labour mobility, land reform, land value tax, manufacturing employment, means of production, Mikhail Gorbachev, Neil Kinnock, new economy, non-tariff barriers, North Sea oil, offshore financial centre, old-boy network, packet switching, Philip Mirowski, Piper Alpha, plutocrats, Plutocrats, post-industrial society, rising living standards, road to serfdom, Ronald Reagan, The inhabitant of London could order by telephone, sipping his morning tea in bed, the various products of the whole earth, trade liberalization, union organizing, very high income, wages for housework, wealth creators, Winter of Discontent, women in the workforce, working poor
Foreword to the 3rd edition of This Is Our Concern (1955) by Alexander Fleck, chairman of ICI. 14. Ibid., p. 1. 15. Ibid., p. 50. 16. Imperial Chemical Industries, ICI Wilton Works (1970). 17. Alan S. Milward and George Brennan, Britain’s Place in the World: A Historical Inquiry into Import Controls 1945–60 (London, 1996), p. 245. 18. Goulburn Evening Post (NSW), 18 May 1951, p. 7. 19. Kersten T. Hall, The Man in the Monkeynut Coat: William Astbury and the Forgotten Road to the Double-Helix (Oxford, 2014). 20. The Charleville Times (Brisbane), 22 November 1951. 21. The Argus (Melbourne), 5 April 1951. 22. Art Buchwald, ‘It Might Serve as a Sackcloth’, Detroit Free Press, 3 November 1957 (syndicated). 23. Nicholas J. White, ‘Government and Business Divided: Malaya, 1945–57’, The Journal of Imperial and Commonwealth History 22 (1994), pp. 251–74. 24. Edmund Dell, Political Responsibility and Industry (London, 1973), p. 120. 25.
.), The Peculiarities of Liberal Modernity in Imperial Britain (Berkeley, California, 2011). Haeussler, Mathias, ‘The Popular Press and Ideas of Europe: The Daily Mirror, the Daily Express, and Britain’s First Application to Join the EEC, 1961–63’, Twentieth Century British History 25 (2014), pp. 108–31. Hall, Kersten T. The Man in the Monkeynut Coat: William Astbury and the Forgotten Road to the Double-Helix (Oxford, 2014). Hall, L. A., Sex, Gender and Social Change in Britain since 1880 (London, 2000). Hall, Stuart and Martin Jacques (eds.), New Times: The Changing Face of Politics in the 1990s (London, 1989). Halsey, A. H., Trends in British Society since 1900 (London, 1972). Hammond Perry, Kennetta, London Is the Place for Me: Black Britons, Citizenship and the Politics of Race (London, 2016).
The Misbehavior of Markets: A Fractal View of Financial Turbulence by Benoit Mandelbrot, Richard L. Hudson
Albert Einstein, asset allocation, Augustin-Louis Cauchy, Benoit Mandelbrot, Big bang: deregulation of the City of London, Black-Scholes formula, British Empire, Brownian motion, business cycle, buy and hold, buy low sell high, capital asset pricing model, carbon-based life, discounted cash flows, diversification, double helix, Edward Lorenz: Chaos theory, Elliott wave, equity premium, Eugene Fama: efficient market hypothesis, Fellow of the Royal Society, full employment, Georg Cantor, Henri Poincaré, implied volatility, index fund, informal economy, invisible hand, John Meriwether, John von Neumann, Long Term Capital Management, Louis Bachelier, mandelbrot fractal, market bubble, market microstructure, Myron Scholes, new economy, paper trading, passive investing, Paul Lévy, Paul Samuelson, plutocrats, Plutocrats, price mechanism, quantitative trading / quantitative ﬁnance, Ralph Nelson Elliott, RAND corporation, random walk, risk tolerance, Robert Shiller, Robert Shiller, short selling, statistical arbitrage, statistical model, Steve Ballmer, stochastic volatility, transfer pricing, value at risk, Vilfredo Pareto, volatility smile
Merged together, the baby takes the father’s trading-time and converts it into a price by the rules the mother provides. Last step: Use the new, baby generator to make a full fractal price chart that is a variant of one of the panels in the “Panorama of financial multifractal.” And there you are: a realistic financial chart, made by stretching and shrinking time. And a nice metaphor for our age, some fifty years after the discovery of the double helix: Each parent contributes one half of a chromosome to the baby. The Baby Theorem. This diagram shows how two generators can pass on traits to a third. The mother generator at top right is a Brownian motion, in conventional clock time—as apparent from the chart of its increments shown above the generator. The father, at bottom right, transforms clock time into a new time-scale, called trading time.
Five Billion Years of Solitude: The Search for Life Among the Stars by Lee Billings
addicted to oil, Albert Einstein, Arthur Eddington, California gold rush, Colonization of Mars, cosmological principle, cuban missile crisis, dark matter, Dava Sobel, double helix, Edmond Halley, full employment, hydraulic fracturing, index card, Isaac Newton, Johannes Kepler, Kuiper Belt, low earth orbit, Magellanic Cloud, music of the spheres, out of africa, Peter H. Diamandis: Planetary Resources, planetary scale, profit motive, quantitative trading / quantitative ﬁnance, Ralph Waldo Emerson, RAND corporation, random walk, Search for Extraterrestrial Intelligence, Searching for Interstellar Communications, selection bias, Silicon Valley, Solar eclipse in 1919, technological singularity, the scientific method, transcontinental railway
His stained-glass window displayed the resulting output: a top row of dots establishing a binary counting method, listing numbers one through ten, followed by a second row listing the atomic numbers of hydrogen, carbon, nitrogen, oxygen, and phosphorus, the key chemical elements of all life on Earth. A third section assembled the preceding atomic numbers into chemical formulas for the nucleotides in a molecule of DNA, followed by a schematic depiction of a DNA molecule’s distinctive double helix. A long vertical bar represented the DNA molecule’s sugar-phosphate backbone, and doubled as a binary depiction of 3 billion, roughly the number of nucleotide base pairs within the human genome. The molecule’s image hovered over the head of a stick-figure human being, which was sandwiched between two more binary numbers, 4 billion and 14. Four billion was meant to convey the world population in 1974, and 14, multiplied by the transmission’s wavelength of 12.6 centimeters, was intended to show that the human figure stands 176 centimeters high—just as tall, it turns out, as Frank Drake.
Composing a Further Life: The Age of Active Wisdom by Mary Catherine Bateson
affirmative action, Berlin Wall, Celebration, Florida, desegregation, double helix, estate planning, feminist movement, invention of writing, Ronald Reagan, Rosa Parks, sexual politics, Silicon Valley, Thomas Kuhn: the structure of scientific revolutions, urban renewal, War on Poverty, women in the workforce
By the time I met Hank, he had learned a wide variety of skills in working with precious metals and semiprecious stones. The first example of his work that I saw was a chain necklace, given to me by Dick and Barbara. Such chains are made link by double or single link from different thicknesses of silver wire, then twisted together like a cable with a variety of textures. The Goldsbys, who are both biology professors, joked that the chain they gave me represented the double helix of DNA. Hank showed me a variety of other products he had developed, which he was reshaping into a small business. He got out half a dozen silver mussel shells, produced from a few shells brought from the Maine coast to his Tucson workshop, where he had experimented for over a year until he had a mold to produce a pendant that met his meticulous standards. On each one, he pointed out small flaws that had allowed him to refine his technique, so that together they provided a narrative of his patient learning.
Icehenge by Kim Stanley Robinson
So often this had happened and I had resolved never to extend myself again — the aquifer was drained, the land above collapsing! — and here just the slightest show of friendship and I had done it again. Not the slightest bit of control over myself. There was something wrong with me, I knew it. I felt it. What I wanted then was a marriage like the Greek ideal, two strong trees grown round each other in a double helix, each stronger for the help of the other, and intertwined for good. Some people found such marriages even in our age, and I wanted one. I was just beginning to understand that my life was a series of discrete lives, and that I could not count on any family or friend to stay with me through more than one life. So that I would never really come to know anybody. Unless I could find that partner, you see, that Greek marriage.
Forty Signs of Rain by Kim Stanley Robinson
bioinformatics, business intelligence, double helix, experimental subject, Intergovernmental Panel on Climate Change (IPCC), phenotype, prisoner's dilemma, Ronald Reagan, social intelligence, stem cell, the scientific method, zero-sum game
The discovery of the incompletability of all systems. The step-by-step mechanics of programming new calculating machines. All this resulted in an amalgam of math and logic, the symbols and methods drawn from both realms, combining in the often long and complicated operations that we call algorithms. In the time of the development of the algorithm, we also made discoveries in the real world: the double helix within our cells. DNA. Within half a century the whole genome was read, base pair by base pair. Three billion base pairs, parts of which are called genes, and serve as instruction packets for protein creation. But despite the fully explicated genome, the details of its expression and growth are still very mysterious. Spiraling pairs of cytosine, guanine, adenine, and thymine: we know these are instructions for growth, for the development of life, all coded in sequences of paired elements.
Origin Story: A Big History of Everything by David Christian
Albert Einstein, Arthur Eddington, butterfly effect, Capital in the Twenty-First Century by Thomas Piketty, Cepheid variable, colonial rule, Colonization of Mars, Columbian Exchange, complexity theory, cosmic microwave background, cosmological constant, creative destruction, cuban missile crisis, dark matter, demographic transition, double helix, Edward Lorenz: Chaos theory, Ernest Rutherford, European colonialism, Francisco Pizarro, Haber-Bosch Process, Harvard Computers: women astronomers, Isaac Newton, James Watt: steam engine, John Maynard Keynes: Economic Possibilities for our Grandchildren, Joseph Schumpeter, Kickstarter, Marshall McLuhan, microbiome, nuclear winter, planetary scale, rising living standards, Search for Extraterrestrial Intelligence, Stephen Hawking, Steven Pinker, The Wealth of Nations by Adam Smith, Thomas Kuhn: the structure of scientific revolutions, trade route, Yogi Berra
From Luca to Prokaryotes Luca and its relatives had already done a lot of the heavy lifting needed to evolve the first true living organisms. But Luca lacked a membrane that it could carry wherever it went, and a metabolism that was not tethered to energy flows near volcanic vents. Luca also seems to have lacked the more sophisticated reproductive mechanism that is present in most modern organisms and is based on RNA’s close relative, the double helix of DNA. At present, we know what had to evolve, but we do not understand the precise pathways by which these things evolved. Explaining the evolution of personal protective membranes is not too difficult. Cell membranes are made from long chains of phospholipids, and it is not hard to persuade phospholipids to link up in layers that form semipermeable bubblelike structures under the right conditions.
Split-Second Persuasion: The Ancient Art and New Science of Changing Minds by Kevin Dutton
availability heuristic, Bernie Madoff, call centre, Cass Sunstein, cognitive bias, cognitive dissonance, credit crunch, different worldview, double helix, Douglas Hofstadter, equity premium, fundamental attribution error, haute couture, job satisfaction, loss aversion, Milgram experiment, placebo effect, Stephen Hawking, Steven Pinker, theory of mind, ultimatum game, upwardly mobile
And while the power of greater numbers reforms us from ‘on high’, the minority works ‘from within’: nudging the brain into questioning reality – into unpicking, then restoring, the transformative fabric of truth. In the following chapter, we turn the spotlight fully on split-second persuasion – placing it under the microscope and mapping its DNA. Is there, we ask, concealed within the melody of mind, a golden chord of influence that all of us can play? Not just the persuasion virtuosi, but the street performers, too? The answer, it turns out, is yes. Our analysis uncovers the double helix of influence, enshrined within which lies persuasion’s secret code. Attributional Style Test The following ten statements refer to different ways of looking at life events. Indicate on the scale provided the extent to which you either agree or disagree with each one. For example, if you strongly agree with the statement, circle 4. If you strongly disagree, circle 1. The scale will appear at the end of each statement. 1.
The New Harvest: Agricultural Innovation in Africa by Calestous Juma
agricultural Revolution, Albert Einstein, barriers to entry, bioinformatics, business climate, carbon footprint, clean water, colonial rule, conceptual framework, creative destruction, double helix, energy security, energy transition, global value chain, income per capita, industrial cluster, informal economy, Intergovernmental Panel on Climate Change (IPCC), Joseph Schumpeter, knowledge economy, land tenure, M-Pesa, microcredit, mobile money, non-tariff barriers, off grid, out of africa, precision agriculture, Second Machine Age, self-driving car, Silicon Valley, sovereign wealth fund, structural adjustment programs, supply-chain management, total factor productivity, undersea cable
Ultimately, if Africa decides that these newest biotechnology techniques are in its best interest, countries must establish their own protocols and must decide for themselves how to classify genetically edited crops. Conclusion Probably the most significant research and educational opportunities for African countries in biotechnology lie in the potential to join the genomics revolution as the costs of sequencing genomes drop. When James Watson, co-discoverer of the DNA double-helix, had his genome sequenced in 2008 by 454 Life Sciences, the price tag was US$1.5 million. A year later a California-based firm, Applied Biosystems, revealed that it has sequenced the genome of a Nigerian man for under US$60,000. In 2010 another California-based firm, Illumina, announced that it had reduced the cost to about US$20,000. New machines can now sequence a human genome for just $1,000.48 Dozens of genomes of agricultural, medical, and environmental importance to Africa have already been seque nced.
Thinking About It Only Makes It Worse: And Other Lessons From Modern Life by David Mitchell
bank run, Boris Johnson, British Empire, cognitive dissonance, collapse of Lehman Brothers, credit crunch, don't be evil, double helix, Downton Abbey, Etonian, eurozone crisis, haute cuisine, Julian Assange, lateral thinking, Northern Rock, offshore financial centre, payday loans, plutocrats, Plutocrats, profit motive, sensible shoes, Skype, The Wisdom of Crowds, WikiLeaks
They may think women can do anything else men can do – right up to rocket science, brain surgery and transubstantiation – but that female intelligence cuts off just before that most elusive and nuanced of human ideas, the offside rule. If that’s the case, Keys and Gray are a bit sexist, but their main mental health problem is believing a slightly tricky rule from an incredibly straightforward game – a notion on the level of buying hotels in Monopoly – is like existentialism, string theory, the double helix, long division and backing-up-Nokia-phone-contacts-on-an-Apple-computer all rolled into one. But it may be that they’ve got a better sense of proportion about the trickiness of offside, yet still consider it to be beyond any woman’s intellectual grasp. If that’s the case, they must spend most of their lives looking around in horrified bewilderment. They think women are imbeciles and yet there women are, walking around, wearing clothes, holding down jobs, being allowed to vote – driving around in cars, for God’s sake!
Sleepyhead: Narcolepsy, Neuroscience and the Search for a Good Night by Henry Nicholls
A. Roger Ekirch, Donald Trump, double helix, Drosophila, global pandemic, Kickstarter, longitudinal study, meta analysis, meta-analysis, mouse model, placebo effect, Saturday Night Live, stem cell, web application, Yom Kippur War
Every April there’s a peak in patients noticing symptoms of narcolepsy and every November there’s a trough. I think back to the onset of my own symptoms, more than 20 years ago. It was April 1994, or thereabouts. Did I suffer a nasty infection that winter? In all honesty I don’t remember. But I do know that my girlfriend at the time battled through November 1993 with a horrific strep throat, so I would certainly have encountered these same pathogens too. I add a double helix and an electron micrograph of Streptococcus to ‘the board’ to indicate the genetic predisposition and a subsequent infection. But taking a step back, I’m a little uneasy with the evidence gathered so far. All of it is circumstantial, nothing establishing a causal link between an infection and narcolepsy. What would really advance the case for the prosecution? An experiment would be nice, with a large number of volunteers assigned at random to one of two treatments.
Einstein's Dice and Schrödinger's Cat: How Two Great Minds Battled Quantum Randomness to Create a Unified Theory of Physics by Paul Halpern
Albert Einstein, Albert Michelson, Arthur Eddington, Brownian motion, clockwork universe, cosmological constant, dark matter, double helix, Ernest Rutherford, Fellow of the Royal Society, Isaac Newton, Johannes Kepler, John von Neumann, lone genius, Murray Gell-Mann, New Journalism, orbital mechanics / astrodynamics, Richard Feynman, Schrödinger's Cat, Solar eclipse in 1919, The Present Situation in Quantum Mechanics
Pointing out that most natural systems tend toward increasing entropy (disorder), he showed how life maintains itself as orderly through the absorption of energy, such as from the Sun. He also speculated that an aperiodic crystal (a nonrepeating arrangement of atoms) played a role in the development of life. Hence he was one of the first to suggest that life was encoded by a chemical sequence. A book based on Schrödinger’s lectures would serve as a source of inspiration for biologists in the 1950s, such as James Watson and Francis Crick, as they developed the double-helix model of DNA. The popular lectures drew the attention of Time magazine, which reported, “Schrödinger has a way with him. His soft, cheerful speech, his whimsical smile are engaging. And Dubliners are proud to have a Nobel prizewinner living among them.”25 174 Luck of the Irish When the Irish Press first reported about Schrödinger’s general unitary theory, it sent Einstein a copy of the article to gauge his reaction.
Memoirs of an Addicted Brain: A Neuroscientist Examines His Former Life on Drugs by Marc Lewis Phd
These two feedback loops amplify each other. As shown in Figure 4, they are interlocked, because that’s how the brain works. But they are even more tightly interlocked in the brain of the addict, in my brain, because they shut out competing inputs, alternative meanings. They go round and round, building on themselves, releasing more dopamine and more glutamate in an ever-tightening spiral, a double helix of neural excitation. Producing a state of directed desire: desire that’s come to a point, so that nothing else matters. It’s not just craving, it’s customized craving, narrowly aimed. An ever-tightening spiral that is the outcome of its own recurrent history of synaptic selection. FIGURE 4. Two feedback loops connecting the orbitofrontal cortex, amygdala, ventral tegmental area (VTA), and ventral striatum, through dopamine and glutamate pathways.
Immortality: The Quest to Live Forever and How It Drives Civilization by Stephen Cave
Albert Einstein, Any sufficiently advanced technology is indistinguishable from magic, back-to-the-land, clean water, double helix, George Santayana, invention of the printing press, Isaac Newton, Lao Tzu, life extension, planetary scale, Ray Kurzweil, stem cell, technoutopianism, the scientific method
It is a nice irony that if Pauling had been allowed to travel to England in 1952 he would most likely have visited the laboratory of a certain young researcher, Rosalind Franklin, at King’s College, London, who was producing detailed images of DNA crystals. Pauling was at the time attempting to deduce the structure of DNA—a fact that, when they heard it, almost made the Cambridge University team including Francis Crick and James Watson give up immediately. But, unlike Pauling, Crick and Watson had seen Franklin’s crucial images and so were able to work out the now-famous double helix structure—a huge leap forward and triumph of the Engineering Approach. It is likely that if Pauling had been allowed to travel, he would have beaten them to it: by denying him a passport, the U.S. government ironically prevented one of the great achievements of twentieth-century science from being claimed by America. In November 1954, it was announced that Linus Pauling was to receive the Nobel Prize in Chemistry.
The Creativity Code: How AI Is Learning to Write, Paint and Think by Marcus Du Sautoy
3D printing, Ada Lovelace, Albert Einstein, Alvin Roth, Andrew Wiles, Automated Insights, Benoit Mandelbrot, Claude Shannon: information theory, computer vision, correlation does not imply causation, crowdsourcing, data is the new oil, Donald Trump, double helix, Douglas Hofstadter, Elon Musk, Erik Brynjolfsson, Fellow of the Royal Society, Flash crash, Gödel, Escher, Bach, Henri Poincaré, Jacquard loom, John Conway, Kickstarter, Loebner Prize, mandelbrot fractal, Minecraft, music of the spheres, Narrative Science, natural language processing, Netflix Prize, PageRank, pattern recognition, Paul Erdős, Peter Thiel, random walk, Ray Kurzweil, recommendation engine, Rubik’s Cube, Second Machine Age, Silicon Valley, speech recognition, Turing test, Watson beat the top human players on Jeopardy!, wikimedia commons
The creativity all came from Hassabis and his ability to see what the right responses were to win the game. It still felt a bit like magic though. Code up the right spell and then, rather like the Sorcerer’s Apprentice, the Commodore would go through the work of winning the game. Hassabis raced through school, culminating with an offer from Cambridge to study computer science at the age of sixteen. He’d set his heart on Cambridge after seeing Jeff Goldblum in the film The Race for the Double Helix. ‘I thought, is this what goes on at Cambridge? You go there and you invent DNA in the pub? Wow.’ Cambridge wouldn’t let him start his degree at the age of sixteen, so he had to defer for a year. To fill his time he won a place working for a game developer after having come second in a competition run by Amiga Power magazine. While he was there, he created his own game, Theme Park, where players had to build and run their own theme park.
Present Shock: When Everything Happens Now by Douglas Rushkoff
algorithmic trading, Andrew Keen, bank run, Benoit Mandelbrot, big-box store, Black Swan, British Empire, Buckminster Fuller, business cycle, cashless society, citizen journalism, clockwork universe, cognitive dissonance, Credit Default Swap, crowdsourcing, Danny Hillis, disintermediation, Donald Trump, double helix, East Village, Elliott wave, European colonialism, Extropian, facts on the ground, Flash crash, game design, global pandemic, global supply chain, global village, Howard Rheingold, hypertext link, Inbox Zero, invention of agriculture, invention of hypertext, invisible hand, iterative process, John Nash: game theory, Kevin Kelly, laissez-faire capitalism, lateral thinking, Law of Accelerating Returns, loss aversion, mandelbrot fractal, Marshall McLuhan, Merlin Mann, Milgram experiment, mutually assured destruction, negative equity, Network effects, New Urbanism, Nicholas Carr, Norbert Wiener, Occupy movement, passive investing, pattern recognition, peak oil, price mechanism, prisoner's dilemma, Ralph Nelson Elliott, RAND corporation, Ray Kurzweil, recommendation engine, selective serotonin reuptake inhibitor (SSRI), Silicon Valley, Skype, social graph, South Sea Bubble, Steve Jobs, Steve Wozniak, Steven Pinker, Stewart Brand, supply-chain management, the medium is the message, The Wisdom of Crowds, theory of mind, Turing test, upwardly mobile, Whole Earth Catalog, WikiLeaks, Y2K, zero-sum game
Indeed, in spite of widespread confidence that we will crack the human code and replicate cognition within just a couple of decades, biology has a way of foiling even its most committed pursuers. The more we learn about DNA and the closer we come to mapping the entire genome, for example, the more we learn how small a part of the total picture it composes. We are no more determined by the neatly identifiable codons of the double helix than we are by the confused protein soup in which it actually operates. Put the same codons in a different person or species, and you’ll get very different results. Our picture of human cognition is even hazier, with current psychopharmacology taking a shotgun approach to regulating neurotransmitters whose actual functioning we have only begun to understand. At our current level of technological sophistication, to argue that a virtual Second Life* simulation will soon become indistinguishable from real life smacks of fantasy and hubris.
France (Lonely Planet, 8th Edition) by Nicola Williams
active transport: walking or cycling, back-to-the-land, bike sharing scheme, British Empire, car-free, carbon footprint, centre right, Charles Lindbergh, Columbine, double helix, Guggenheim Bilbao, haute couture, haute cuisine, Henri Poincaré, Honoré de Balzac, illegal immigration, industrial robot, information trail, Jacquard loom, Joseph-Marie Jacquard, Kickstarter, Louis Blériot, Louis Pasteur, low cost airline, low cost carrier, Mahatma Gandhi, means of production, Murano, Venice glass, pension reform, post-work, QWERTY keyboard, ride hailing / ride sharing, Saturday Night Live, Silicon Valley, Skype, Sloane Ranger, supervolcano, trade route, urban renewal, urban sprawl, V2 rocket
Thrills abound for those with a passion for the unconventional. * * * France’s soulful capital seduces: the Eiffel Tower is the peak of romance. Pop the question Gothic-style in Hôtel St-Merry. Nip north to chink glasses on Champagne’s wine route, or west to the Loire Valley and its châteaux: see love blossoming at Villandry; a drama of passion and betrayal unfold at Chenonceau; or meet your lover on the double-helix staircase at Château de Chambord. Don’t miss Brittany’s haunting Île d’Ouessant. Oysters, for which Cancale is famed, are an aphrodisiac. Tempting to lonely hearts and lovers is Belle Île, with its caves and beaches steeped in legend. Shouting ‘yes’ from a huge sand dune or in the surf on the Atlantic Coast is not a bad idea. Or smooching atop Mont Aigoual or paragliding above Puy de Dôme. Provence and the Côte d’Azur are love at first sight.
The result is an astonishingly rich collection of architectural treasures, ranging from the medieval fortresses of Chinon, Angers and Loches through to the extravagant pleasure palaces of Azay-le-Rideau, Chenonceau and Chambord. If it’s aristocratic pomp and architectural splendour you’re looking for, the Loire Valley is a place to linger. * * * HIGHLIGHTS Join the Joan of Arc trail in the historic city of Orléans Explore the cloisters and chapels of the Loire Valley’s greatest ecclesiastical complex, Abbaye Royale de Fontevraud Climb up the fabulous double-helix staircase to the turret-covered rooftop of Chambord, the Loire Valley’s most over-the-top château Visit the retirement home of the original Renaissance Man, Leonardo da Vinci, at Clos Lucé Admire the fabulous kitchen gardens and floral displays of Villandry Wander around the hobbit houses and mushroom museums of the Troglodyte Valley POPULATION: 2,589,000 AREA: 33,646 SQ KM * * * History The Loire River was one of Roman Gaul’s most important transport arteries.
Though construction was repeatedly halted by financial problems, design setbacks and military commitments (not to mention the kidnapping of the king’s two sons in Spain), by the time Chambord was finally finished 30-odd years later, the castle boasted some 440 rooms, 365 fireplaces, and 84 staircases, not to mention a cityscape of turrets, chimneys and lanterns crowning its rooftop, and a famous double-helix staircase, supposedly designed by the king’s chum, Leonardo da Vinci. Ironically, François ultimately found his elaborate palace too draughty, preferring the royal apartments in Amboise and Blois – he only stayed here for 42 days during his entire reign from 1515 to 1547. Despite its apparent complexity, Chambord is laid out according to simple mathematical rules. Each section is arranged on a system of symmetrical grid squares around a Maltese cross.
Radical Abundance: How a Revolution in Nanotechnology Will Change Civilization by K. Eric Drexler
3D printing, additive manufacturing, agricultural Revolution, Bill Joy: nanobots, Brownian motion, carbon footprint, Cass Sunstein, conceptual framework, continuation of politics by other means, crowdsourcing, dark matter, double helix, failed state, global supply chain, industrial robot, iterative process, Mars Rover, means of production, Menlo Park, mutually assured destruction, New Journalism, performance metric, reversible computing, Richard Feynman, Silicon Valley, South China Sea, Thomas Malthus, V2 rocket, Vannevar Bush, zero-sum game
Starting in the 1980s, Nadrian Seeman developed structures based on branched DNA assemblies, and structural DNA nanotechnology (as the field is now called) made major strides in the 1990s. Since then, the field has gone through a series of revolutions culminating in the ability to engineer atomically precise molecular frameworks on a scale of millions of atoms and hundreds of nanometers, using a technique called “DNA origami.” The simple, pairwise matching of DNA strands to form the predictable, rod-like structure of the DNA double helix has provided a molecular engineering method that can be as predictable as carpentry. In this analogy, short, single DNA strands play the role of the nails (technically termed “staples”), crossing between double helical strands to fasten them together. The products made to date include rectangles with arrays of hundreds of DNA-addressable binding sites, struts forming octahedra, and boxes with lids that latch and unlatch.
Drugs Without the Hot Air by David Nutt
British Empire, double helix, en.wikipedia.org, Kickstarter, knowledge economy, longitudinal study, meta analysis, meta-analysis, moral panic, offshore financial centre, randomized controlled trial, risk tolerance, Robert Gordon, selective serotonin reuptake inhibitor (SSRI), War on Poverty
I did some quick calculations … it would fit on the property and not only that … it would meet the cost and income requirements … I began to draw …my senses could not keep up with my images.” The image stayed with him just as sharply after the drug experience had ended, and his design was accepted and constructed. Even in the less-obviously creative fields of hard science, LSD can be profoundly beneficial. In fact, it played a role in the two biggest discoveries in biology of the 20th century. 14Francis Crick, who discovered the double helix structure of DNA with James Watson, and 15Kary Mullis, who invented the 16polymerase chain reaction (PCR), had both taken the drug, and attributed some of their understanding and insights to it. Mullis has gone so far as to say: “would I have invented PCR if I hadn’t taken LSD? I seriously doubt it … [having taken LSD] I could sit on a DNA molecule and watch the polymers go by. I learnt that partly on psychedelic drugs.”
Augmented: Life in the Smart Lane by Brett King
23andMe, 3D printing, additive manufacturing, Affordable Care Act / Obamacare, agricultural Revolution, Airbnb, Albert Einstein, Amazon Web Services, Any sufficiently advanced technology is indistinguishable from magic, Apple II, artificial general intelligence, asset allocation, augmented reality, autonomous vehicles, barriers to entry, bitcoin, blockchain, business intelligence, business process, call centre, chief data officer, Chris Urmson, Clayton Christensen, clean water, congestion charging, crowdsourcing, cryptocurrency, deskilling, different worldview, disruptive innovation, distributed generation, distributed ledger, double helix, drone strike, Elon Musk, Erik Brynjolfsson, Fellow of the Royal Society, fiat currency, financial exclusion, Flash crash, Flynn Effect, future of work, gig economy, Google Glasses, Google X / Alphabet X, Hans Lippershey, Hyperloop, income inequality, industrial robot, information asymmetry, Internet of things, invention of movable type, invention of the printing press, invention of the telephone, invention of the wheel, James Dyson, Jeff Bezos, job automation, job-hopping, John Markoff, John von Neumann, Kevin Kelly, Kickstarter, Kodak vs Instagram, Leonard Kleinrock, lifelogging, low earth orbit, low skilled workers, Lyft, M-Pesa, Mark Zuckerberg, Marshall McLuhan, megacity, Metcalfe’s law, Minecraft, mobile money, money market fund, more computing power than Apollo, Network effects, new economy, obamacare, Occupy movement, Oculus Rift, off grid, packet switching, pattern recognition, peer-to-peer, Ray Kurzweil, RFID, ride hailing / ride sharing, Robert Metcalfe, Satoshi Nakamoto, Second Machine Age, selective serotonin reuptake inhibitor (SSRI), self-driving car, sharing economy, Shoshana Zuboff, Silicon Valley, Silicon Valley startup, Skype, smart cities, smart grid, smart transportation, Snapchat, social graph, software as a service, speech recognition, statistical model, stem cell, Stephen Hawking, Steve Jobs, Steve Wozniak, strong AI, TaskRabbit, technological singularity, telemarketer, telepresence, telepresence robot, Tesla Model S, The Future of Employment, Tim Cook: Apple, trade route, Travis Kalanick, Turing complete, Turing test, uber lyft, undersea cable, urban sprawl, V2 rocket, Watson beat the top human players on Jeopardy!, white picket fence, WikiLeaks
We call them “linear decay factors” because they are roughly linear, either on normal graph paper or if put on a logarithmic scale. We call the process of doing everything it takes to neutralise these linear decay factors, or even start getting improvement again, the “Activated Self”. It is what we will logically do in the future with all that data we’re collecting and interpreting about our health. Telomere Length Telomeres are the end caps on our chromosomes, which are made of the tightly wrapped double helix of our DNA. They are sometimes compared with aglets, the little pieces of plastic at the ends of your shoelaces. We have 15,000 units of telomeres at conception. Each time our cells divide, we lose telomeres. Our cells divide so many times while we are in the womb that by the time we are born, we have only 10,000 remaining units. A typical human who dies of natural causes in old age will have around 5,000 units or so.
Ask Me About My Uterus: A Quest to Make Doctors Believe in Women's Pain by Abby Norman
Affordable Care Act / Obamacare, complexity theory, correlation does not imply causation, double helix, Downton Abbey, feminist movement, financial independence, Kickstarter, period drama, phenotype, Saturday Night Live, the scientific method, women in the workforce
It felt good to be close to him because I was attracted to him and aroused by him. Having his arms around me, in other words, was a nice feeling, but one that invariably led to, “Okay, now let me suck your dick.” It was the “hurts so good” intensity of attraction. His embrace was molecularly energizing. I’ve had strange moments throughout my life where it feels as though I am expanding infinitely out into the universe, as though every double helix of my DNA were unfurling. It felt like every atom of my body was being drawn back to the cosmos by some unseen force, and was trying to return to whatever star I came from. In these moments, I find myself desperately wanting to be held. But more than held—stilled. Physical closeness with a man (sometimes as little as proximity—touching isn’t strictly necessary) inspires sexual stirrings in me because I’m straight.
Dirty Genes: A Breakthrough Program to Treat the Root Cause of Illness and Optimize Your Health by Ben Lynch Nd.
Cardiovascular Function Faulty methylation can lead to atherosclerosis (hardening of the arteries) and hypertension, both dangerous to cardiovascular health. Excessive and/or chronic inflammation—which can be created by poor methylation—has also been implicated in cardiovascular disease. DNA Repair Your genetic instructions are embodied in your DNA, the deoxyribonucleic acid that is the biochemical code for life itself. Two strands of DNA, wrapped together in a spiraling double helix, contain the particular sequence of molecules that say who you are—and that tell your cells what to do to keep you alive and well. Just as the couch in your family room is constantly undergoing wear and tear from being used so often, so is your DNA. Your body’s own biochemical processes can damage your DNA, as can exposure to free radicals (unstable, highly reactive molecules), ultraviolet B rays (UVB), and certain biochemicals.
The End of Doom: Environmental Renewal in the Twenty-First Century by Ronald Bailey
3D printing, additive manufacturing, agricultural Revolution, Albert Einstein, Asilomar, autonomous vehicles, business cycle, Cass Sunstein, Climatic Research Unit, Commodity Super-Cycle, conceptual framework, corporate governance, creative destruction, credit crunch, David Attenborough, decarbonisation, dematerialisation, demographic transition, disruptive innovation, diversified portfolio, double helix, energy security, failed state, financial independence, Gary Taubes, hydraulic fracturing, income inequality, Induced demand, Intergovernmental Panel on Climate Change (IPCC), invisible hand, knowledge economy, meta analysis, meta-analysis, Naomi Klein, oil shale / tar sands, oil shock, pattern recognition, peak oil, Peter Calthorpe, phenotype, planetary scale, price stability, profit motive, purchasing power parity, race to the bottom, RAND corporation, rent-seeking, Stewart Brand, Tesla Model S, trade liberalization, University of East Anglia, uranium enrichment, women in the workforce, yield curve
They self-consciously thought that they were avoiding what they saw as the mistakes made a generation earlier by Manhattan Project nuclear physicists when they unleashed the power of the atom. The initially restrictive guidelines have been greatly relaxed, not least because it turns out that microorganisms are natural and promiscuous exchangers of genes. Reflecting later on the hysteria and rush to regulate, James Watson, codiscoverer of the double-helix structure of DNA, for which he won the Nobel Prize, succinctly noted, “Scientifically I was a nut. There is no evidence at all that recombinant DNA poses the slightest danger.” Similarly, biophysicist Burke Zimmerman, who participated in the congressional debates over regulating biotechnology, concluded, “In looking back, it would be hard to insist that a law was necessary, or, perhaps, that guidelines were necessary.”
Misspent Youth by Peter F. Hamilton
Yesterday Brussels had been dominated by the auditors refusing to sign off on the commission accounts for the fifteenth year in a row. But this was different; this was a human story, this was the official discovery of the fountain of youth. A long table had been set up on the raised stage, complete with the traditional glasses of water and silver microphones. Behind it, a huge screen was displaying a colorful double helix that writhed and twisted like a tormented serpent. The senior press officer looked across the audience of familiar cynical faces, took a deep breath to calm his fluttering nerves, and announced that they were ready to begin. President Jean Brèque walked onto the stage first. The press corps politely rose. Rob Lacey, the British prime minister, was next, producing his standardized lopsided smile for the newspool feed cameras.
How Not to Network a Nation: The Uneasy History of the Soviet Internet (Information Policy) by Benjamin Peters
Albert Einstein, American ideology, Andrei Shleifer, Benoit Mandelbrot, bitcoin, Brownian motion, Claude Shannon: information theory, cloud computing, cognitive dissonance, computer age, conceptual framework, continuation of politics by other means, crony capitalism, crowdsourcing, cuban missile crisis, Daniel Kahneman / Amos Tversky, David Graeber, Dissolution of the Soviet Union, Donald Davies, double helix, Drosophila, Francis Fukuyama: the end of history, From Mathematics to the Technologies of Life and Death, hive mind, index card, informal economy, information asymmetry, invisible hand, Jacquard loom, John von Neumann, Kevin Kelly, knowledge economy, knowledge worker, linear programming, mandelbrot fractal, Marshall McLuhan, means of production, Menlo Park, Mikhail Gorbachev, mutually assured destruction, Network effects, Norbert Wiener, packet switching, Pareto efficiency, pattern recognition, Paul Erdős, Peter Thiel, Philip Mirowski, RAND corporation, rent-seeking, road to serfdom, Ronald Coase, scientific mainstream, Steve Jobs, Stewart Brand, stochastic process, technoutopianism, The Structural Transformation of the Public Sphere, transaction costs, Turing machine
Many scientists worldwide were rushing to find ways to stabilize and regulate the consequences of a torrent of new and disruptive technologies—and cybernetics modeled a technical mindset for how to grapple with and control the consequences of technology itself. The 1950s saw a dizzying number of potentially revolutionary technologies become popular—atomic and hydrogen bombs, nuclear power plants, Sputnik, the double helix, passenger jets, dishwashers, polio vaccines, the lobotomy (invented in the 1930s), television, and transistor radios—and other trends, such as rock & roll and suburban housing developments. The disruptive influences of modern science and technology continued to be felt in the 1960s as quarks, lasers, Apollo, nylon, Pampers, the pill, LSD, napalm, DDT, mutually assured destruction, and the ARPANET entered the world stage.
The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World by Pedro Domingos
Albert Einstein, Amazon Mechanical Turk, Arthur Eddington, basic income, Bayesian statistics, Benoit Mandelbrot, bioinformatics, Black Swan, Brownian motion, cellular automata, Claude Shannon: information theory, combinatorial explosion, computer vision, constrained optimization, correlation does not imply causation, creative destruction, crowdsourcing, Danny Hillis, data is the new oil, double helix, Douglas Hofstadter, Erik Brynjolfsson, experimental subject, Filter Bubble, future of work, global village, Google Glasses, Gödel, Escher, Bach, information retrieval, job automation, John Markoff, John Snow's cholera map, John von Neumann, Joseph Schumpeter, Kevin Kelly, lone genius, mandelbrot fractal, Mark Zuckerberg, Moneyball by Michael Lewis explains big data, Narrative Science, Nate Silver, natural language processing, Netflix Prize, Network effects, NP-complete, off grid, P = NP, PageRank, pattern recognition, phenotype, planetary scale, pre–internet, random walk, Ray Kurzweil, recommendation engine, Richard Feynman, scientific worldview, Second Machine Age, self-driving car, Silicon Valley, social intelligence, speech recognition, Stanford marshmallow experiment, statistical model, Stephen Hawking, Steven Levy, Steven Pinker, superintelligent machines, the scientific method, The Signal and the Noise by Nate Silver, theory of mind, Thomas Bayes, transaction costs, Turing machine, Turing test, Vernor Vinge, Watson beat the top human players on Jeopardy!, white flight, zero-sum game
But once Maxwell figured out how a changing electric field gives rise to magnetism and vice versa, it became clear that light itself is an intimate marriage of the two, and today we know that, far from rare, electromagnetism pervades all matter. Mendeleev’s periodic table not only organized all the known elements into just two dimensions, it also predicted where new elements would be found. Darwin’s observations aboard the Beagle suddenly began to make sense when Malthus’s Essay on Population suggested natural selection as the organizing principle. When Crick and Watson hit on the double helix structure as an explanation for the puzzling properties of DNA, they immediately saw how it might replicate itself, and biology’s transition from stamp collecting (in Rutherford’s pejorative words) to unified science had begun. In each of these cases, a bewildering variety of observations turned out to have a common cause, and once scientists identified it, they could in turn use it to predict many new phenomena.
The Diet Myth: The Real Science Behind What We Eat by Tim Spector
biofilm, British Empire, Colonization of Mars, cuban missile crisis, David Strachan, double helix, Drosophila, epigenetics, hygiene hypothesis, Kickstarter, life extension, longitudinal study, Mahatma Gandhi, meta analysis, meta-analysis, microbiome, phenotype, randomized controlled trial, Steve Jobs, twin studies
colon: the lower part of the intestines, where most of our bacteria and microbes live and digest the fibre-rich food that hasn’t been absorbed higher up in the small intestine. diabetes: two diseases resulting from too much sugar (glucose) in the blood. The commonest is Type 2, which is related to obesity and to our genes and makes insulin ineffective, causing blood glucose to rise and excessive insulin to be produced in compensation. DNA: Deoxyribonucleic acid is the building block of our genetic material; it is arranged as a double helix in 23 chromosomes and contains the roughly 20,000 genes in each cell of our bodies. E. coli: a common bacteria that lives in our colons and can occasionally become pathogenic after infections or antibiotics. endocrine: a term for anything producing hormones (e.g. thyroid or pancreas). endocrine disruptors: chemicals that act epigenetically to alter hormones, e.g. the bisphenol (BPA) in plastic bottles.
The Selfish Gene by Richard Dawkins
Usurper or not, DNA is in undisputed charge today, unless, as I tentatively suggest in Chapter 11, a new seizure of power is now just beginning. A DNA molecule is a long chain of building blocks, small molecules called nucleotides. Just as protein molecules are chains of amino acids, so DNA molecules are chains of nucleotides. A DNA molecule is too small to be seen, but its exact shape has been ingeniously worked out by indirect means. It consists of a pair of nucleotide chains twisted together in an elegant spiral; the 'double helix'; the 'immortal coil'. The nucleotide building blocks come in only four different kinds, whose names may be shortened to A, T, C, and G. These are the same in all animals and plants. What differs is the order in which they are strung together. A G building block from a man is identical in every particular to a G building block from a snail. But the sequence of building blocks in a man is not only different from that in a snail.
Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries by Safi Bahcall
accounting loophole / creative accounting, Albert Einstein, Apple II, Apple's 1984 Super Bowl advert, Astronomia nova, British Empire, Cass Sunstein, Charles Lindbergh, Clayton Christensen, cognitive bias, creative destruction, disruptive innovation, diversified portfolio, double helix, Douglas Engelbart, Douglas Engelbart, Edmond Halley, Gary Taubes, hypertext link, invisible hand, Isaac Newton, Johannes Kepler, Jony Ive, knowledge economy, lone genius, Louis Pasteur, Mark Zuckerberg, Menlo Park, Mother of all demos, Murray Gell-Mann, PageRank, Peter Thiel, Philip Mirowski, Pierre-Simon Laplace, prediction markets, pre–internet, Ralph Waldo Emerson, RAND corporation, random walk, Richard Feynman, Richard Thaler, side project, Silicon Valley, six sigma, Solar eclipse in 1919, stem cell, Steve Jobs, Steve Wozniak, the scientific method, The Wealth of Nations by Adam Smith, The Wisdom of Crowds, Tim Cook: Apple, tulip mania, Wall-E, wikimedia commons, yield management
Miller also served part-time as a physician at Stanford University. He explained that he knew his patients. Many had only months to live, were desperately looking for options, and understood the risks. The potential, in this context, justified the risk. “There’s a quote from Francis Crick that I love,” Miller said. Crick was awarded the Nobel Prize for discovering, along with James Watson, the double-helix structure of DNA. “When asked what it takes to win a Nobel Prize, Crick said, ‘Oh it’s very simple. My secret had been I know what to ignore.’” Miller shared the early laboratory results from his piranha with a handful of physicians, who agreed to proceed with a clinical trial in patients with advanced leukemias. But Miller’s investors were not convinced. (Miller: “To this day, if you ask them [how the drug works], they wouldn’t know.”)
Infinite Powers: How Calculus Reveals the Secrets of the Universe by Steven Strogatz
Albert Einstein, Asperger Syndrome, Astronomia nova, Bernie Sanders, clockwork universe, complexity theory, cosmological principle, Dava Sobel, double helix, Edmond Halley, Eratosthenes, four colour theorem, fudge factor, Henri Poincaré, invention of the telescope, Isaac Newton, Islamic Golden Age, Johannes Kepler, John Harrison: Longitude, Khan Academy, Laplace demon, lone genius, music of the spheres, pattern recognition, Paul Erdős, Pierre-Simon Laplace, precision agriculture, retrograde motion, Richard Feynman, Socratic dialogue, Solar eclipse in 1919, Steve Jobs, the rule of 72, the scientific method
They have proved to be effective targets for cancer-chemotherapy drugs. The mechanism of action is not completely clear, but it is thought that by blocking the action of topoisomerases, the drugs (known as topoisomerase inhibitors) can selectively damage the DNA of cancer cells, which causes them to commit cellular suicide. Good news for the patient, bad news for the tumor. In the application of calculus to supercoiled DNA, the double helix is modeled as a continuous curve. As usual, calculus likes to work with continuous objects. In reality, DNA is a discrete collection of atoms. There’s nothing truly continuous about it. But to a good approximation, it can be treated as if it were a continuous curve, like an ideal rubber band. The advantage of doing that is that the apparatus of elasticity theory and differential geometry, two spinoffs of calculus, can then be applied to calculate how DNA deforms when subjected to forces from proteins, from the environment, and from interactions with itself.
Black Box Thinking: Why Most People Never Learn From Their Mistakes--But Some Do by Matthew Syed
Airbus A320, Alfred Russel Wallace, Arthur Eddington, Atul Gawande, Black Swan, British Empire, call centre, Captain Sullenberger Hudson, Checklist Manifesto, cognitive bias, cognitive dissonance, conceptual framework, corporate governance, creative destruction, credit crunch, crew resource management, deliberate practice, double helix, epigenetics, fear of failure, fundamental attribution error, Henri Poincaré, hindsight bias, Isaac Newton, iterative process, James Dyson, James Hargreaves, James Watt: steam engine, Johannes Kepler, Joseph Schumpeter, Kickstarter, Lean Startup, mandatory minimum, meta analysis, meta-analysis, minimum viable product, publication bias, quantitative easing, randomized controlled trial, selection bias, Shai Danziger, Silicon Valley, six sigma, spinning jenny, Steve Jobs, the scientific method, Thomas Kuhn: the structure of scientific revolutions, too big to fail, Toyota Production System, US Airways Flight 1549, Wall-E, Yom Kippur War
Before the rise of Lysenko, Russian biology had been flourishing. Dmitry Ivanovsky discovered plant viruses in 1892. Ivan Pavlov won the Nobel Prize for Medicine in 1904 for his work on digestion. Ilya Mechnikov won the Nobel Prize in 1908 for his theories on the cellular response to infection. In 1927, Nikolai Koltsov proposed that inherited characteristics are double-stranded giant molecules, anticipating the double helix structure of DNA. By the end of the purges, however, Russian science had been decimated. As Valery Soyfer, a Russian scientist persecuted during the Lysenko era, put it: “The progress of science was slowed or stopped, and millions of university and high school students received a distorted education.”2 This produced a ripple effect on the quality of life for millions of Russians, not least because the agricultural techniques proposed by Lysenko were often ineffective.
The Idea of Israel: A History of Power and Knowledge by Ilan Pappe
affirmative action, Ayatollah Khomeini, Boycotts of Israel, British Empire, double helix, facts on the ground, feminist movement, Francis Fukuyama: the end of history, mass immigration, Nelson Mandela, New Journalism, one-state solution, postnationalism / post nation state, stem cell, urban planning, Yom Kippur War
The Globalisation of Israel: McWorld in Tel Aviv, Jihad in Jerusalem, London and New York: Routledge, 2007. Roberts, J. Contested Land, Contested Memory: Israel’s Jews and Arabs and the Ghosts of Catastrophe, New York: Dundurn, 2013. Rogan, E. and Shlaim, A. (ed.) The War for Palestine: Rewriting the History of 1948, Cambridge: Cambridge University Press, 2007. Rotberg, R. (ed.) Israeli and Palestinian Narratives of Conflict: History’s Double Helix, Bloomington, IN: Indiana University Press, 2006. Sand, S. The Words and the Land: Israeli Intellectuals and the Nationalist Myth, London: Semiotext(e), 2011. Shafir, G. and Peled, Y. Being Israeli: The Dynamics of Multiple Citizenship, Cambridge: Cambridge University Press, 2002. Shatz, A. Prophets Outcast: A Century of Dissident Jewish Writing About Zionism and Israel, New York; Nation Books, 2004.
End of the World Blues by Jon Courtenay Grimwood
Lady Neku ran through the things she might have done wrong. On balance, she’d have to say she’d been pretty good. Maybe it was her most recent trip to the schloss? But…I mean, she thought, they couldn’t possibly know about that. Of course not. Scuffing dust, Lady Neku slid her way to the middle of the corridor and finished with a quick twirl that left her dizzy and slightly breathless in front of a double helix of steps. The spiral came out behind a tapestry in the audience chamber above. Up close one could see that the tapestry of a girl with a unicorn was stitched, but from a distance the picture looked like a painting. It was very old. Millions of years had been mentioned. Right back to the far side of the Great White, when there was only one inhabited planet and this was it. Of course, millions was relative.
Remix by John Courtenay Grimwood
Her court shoes were ruined, as was the Hermès silk scarf wrapped round her neck. Water ran under the collar of her coat, dripped from black-lacquered fingertips and tumbled from the tiny rat tails of her close-cropped grey hair. But the water running over her cheeks was not rain. Not all of it, anyway. The head of the French Empire’s most feared Directorate was weeping. Looking out at the grey ribbon of the swollen river, staring blankly at where the vast cross-and-double-helix hologram of the Church Geneticist should have been, if only that arrondissement had power, Lady Clare let burning tears stream down her frozen face. There was no one to see her misery, and why should she care even if there was? God knew, there was enough horror in the city for even the most hardbitten Minister of the Empire to be crying. Even one rumoured to be more brittle than glass and sharper than diamond.
In Our Own Image: Savior or Destroyer? The History and Future of Artificial Intelligence by George Zarkadakis
3D printing, Ada Lovelace, agricultural Revolution, Airbnb, Alan Turing: On Computable Numbers, with an Application to the Entscheidungsproblem, animal electricity, anthropic principle, Asperger Syndrome, autonomous vehicles, barriers to entry, battle of ideas, Berlin Wall, bioinformatics, British Empire, business process, carbon-based life, cellular automata, Claude Shannon: information theory, combinatorial explosion, complexity theory, continuous integration, Conway's Game of Life, cosmological principle, dark matter, dematerialisation, double helix, Douglas Hofstadter, Edward Snowden, epigenetics, Flash crash, Google Glasses, Gödel, Escher, Bach, income inequality, index card, industrial robot, Internet of things, invention of agriculture, invention of the steam engine, invisible hand, Isaac Newton, Jacquard loom, Jacques de Vaucanson, James Watt: steam engine, job automation, John von Neumann, Joseph-Marie Jacquard, Kickstarter, liberal capitalism, lifelogging, millennium bug, Moravec's paradox, natural language processing, Norbert Wiener, off grid, On the Economy of Machinery and Manufactures, packet switching, pattern recognition, Paul Erdős, post-industrial society, prediction markets, Ray Kurzweil, Rodney Brooks, Second Machine Age, self-driving car, Silicon Valley, social intelligence, speech recognition, stem cell, Stephen Hawking, Steven Pinker, strong AI, technological singularity, The Coming Technological Singularity, The Future of Employment, the scientific method, theory of mind, Turing complete, Turing machine, Turing test, Tyler Cowen: Great Stagnation, Vernor Vinge, Von Neumann architecture, Watson beat the top human players on Jeopardy!, Y2K
Bioinformatics – the accumulation, tagging, storing, manipulation and mining of digital biological data – is the present, and future, of biology research. The computer metaphor for life is reinforced by its apparently successful application to real problems. Many disruptive new technologies in molecular biology – for instance ‘DNA printing’ – function on the basis of digital information. This is how they do it: DNA is a molecule formed by two sets of base pairs: adenine-thymine (A-T) and guanine-cytosine (G-C). The pairs are stacked along the double helix and their sequence defines the hereditary characteristics of the living being13 whose DNA it is. The sequence is called the ‘genome’.14 Let’s imagine these pairs as Lego pieces. In themselves, they are just pieces of boring chemistry. Put them in the right order, however, and you have the recipe for a complex, living creature. By reshuffling the pieces of base pairs and putting them in different sequences biologists ‘recombine’ DNA molecules.
Age of Discovery: Navigating the Risks and Rewards of Our New Renaissance by Ian Goldin, Chris Kutarna
2013 Report for America's Infrastructure - American Society of Civil Engineers - 19 March 2013, 3D printing, Airbnb, Albert Einstein, AltaVista, Asian financial crisis, asset-backed security, autonomous vehicles, banking crisis, barriers to entry, battle of ideas, Berlin Wall, bioinformatics, bitcoin, Bonfire of the Vanities, clean water, collective bargaining, Colonization of Mars, Credit Default Swap, crowdsourcing, cryptocurrency, Dava Sobel, demographic dividend, Deng Xiaoping, Doha Development Round, double helix, Edward Snowden, Elon Musk, en.wikipedia.org, epigenetics, experimental economics, failed state, Fall of the Berlin Wall, financial innovation, full employment, Galaxy Zoo, global pandemic, global supply chain, Hyperloop, immigration reform, income inequality, indoor plumbing, industrial cluster, industrial robot, information retrieval, Intergovernmental Panel on Climate Change (IPCC), intermodal, Internet of things, invention of the printing press, Isaac Newton, Islamic Golden Age, Johannes Kepler, Khan Academy, Kickstarter, low cost airline, low cost carrier, low skilled workers, Lyft, Malacca Straits, mass immigration, megacity, Mikhail Gorbachev, moral hazard, Nelson Mandela, Network effects, New Urbanism, non-tariff barriers, Occupy movement, On the Revolutions of the Heavenly Spheres, open economy, Panamax, Pearl River Delta, personalized medicine, Peter Thiel, post-Panamax, profit motive, rent-seeking, reshoring, Robert Gordon, Robert Metcalfe, Search for Extraterrestrial Intelligence, Second Machine Age, self-driving car, Shenzhen was a fishing village, Silicon Valley, Silicon Valley startup, Skype, smart grid, Snapchat, special economic zone, spice trade, statistical model, Stephen Hawking, Steve Jobs, Stuxnet, The Future of Employment, too big to fail, trade liberalization, trade route, transaction costs, transatlantic slave trade, uber lyft, undersea cable, uranium enrichment, We are the 99%, We wanted flying cars, instead we got 140 characters, working poor, working-age population, zero day
The book of life The study of genes dates back to the 1860s, when an Augustinian friar, Gregor Johann Mendel, patiently bred some 30,000 pea plants and deduced from his monkish observations that the nature of a “child” plant must be due to a combination of dominant and recessive traits inherited from both parents. By around 1900, scientists had figured out that those inherited or “hereditary” traits are carried by chromosomes inside the nucleus of the cell. And by the 1950s, they had located within chromosomes the ultimate vault for our genetic inheritance: a clever, two-strand or “double helix” molecule dubbed DNA. DNA is nature’s language for storing and copying genetic information. It’s digital. But instead of 0s and 1s, each strand comprises a long sequence of A, C, G and T—adenine, cytosine, guanine and thymine, which are four simple molecules present in all cells in all living things. These four molecules have a special property: A will only bond with T, and C will only bond with G.
Mind in Motion: How Action Shapes Thought by Barbara Tversky
Apple's 1984 Super Bowl advert, Asperger Syndrome, augmented reality, clean water, continuous integration, double helix, en.wikipedia.org, fundamental attribution error, Hans Rosling, Intergovernmental Panel on Climate Change (IPCC), John Snow's cholera map, Lao Tzu, meta analysis, meta-analysis, natural language processing, neurotypical, patient HM, Richard Feynman, Steven Pinker, the new new thing, theory of mind, urban planning
FORMS OF DISCOURSE: DESCRIPTION, EXPLANATION, AND STORY Recall that large survey we did of diagrams in college textbooks. We found a small number of discourse forms, essentially descriptions, explanations, and stories. Descriptions included labeling the parts of a leaf or a cell and examples of different kinds of leaves or cells. Explanations included photosynthesis and cell division. Stories included Mendel’s discovery of genetics or Watson and Crick’s double helix of DNA. Yes, they can be diagrammed. The big three, descriptions, explanations, and stories, are also the big three that characterize discourse purely in language. Each of these builds on and expands the previous kind, and any particular piece of discourse, descriptive or depictive, may include a mix of the three kinds. Descriptions present a state of affairs in space or time. A map or a time line.
Milk! by Mark Kurlansky
GMO grain is banned in many other countries, including those belonging to the European Union, although there could be an economic motive behind this, since the banned grain is grown in the United States and if European farmers were to use it they would be buying imported American grain instead of the European product. In 1999, at a celebration of the first twenty-five years of biotechnology, James Dewey Watson, a member of the three-person team that won the 1962 Nobel Prize in Physiology or Medicine for revealing the structure of DNA, the double helix, said that the field of GMOs offered “certain promise and uncertain risk.” Watson’s point of view was that to make progress, you had to take risks. GMOs are indeed a field full of promise. They could produce food that no one would be allergic to, or food that when eaten prevents tooth decay, even perhaps food that fights certain diseases. Since farmed fish draw sea lice, they could produce lice-rejecting fish.
Think Like a Rocket Scientist by Ozan Varol
Affordable Care Act / Obamacare, Airbnb, airport security, Albert Einstein, Amazon Web Services, Andrew Wiles, Apple's 1984 Super Bowl advert, Arthur Eddington, autonomous vehicles, Ben Horowitz, Cal Newport, Clayton Christensen, cloud computing, Colonization of Mars, dark matter, delayed gratification, different worldview, discovery of DNA, double helix, Elon Musk, fear of failure, functional fixedness, Gary Taubes, George Santayana, Google Glasses, Google X / Alphabet X, Inbox Zero, index fund, Isaac Newton, James Dyson, Jeff Bezos, job satisfaction, Johannes Kepler, Kickstarter, knowledge worker, late fees, lateral thinking, lone genius, longitudinal study, Louis Pasteur, low earth orbit, Marc Andreessen, Mars Rover, meta analysis, meta-analysis, move fast and break things, move fast and break things, multiplanetary species, obamacare, Occam's razor, out of africa, Peter Thiel, Pluto: dwarf planet, Ralph Waldo Emerson, Richard Feynman, Richard Feynman: Challenger O-ring, Ronald Reagan, Sam Altman, Schrödinger's Cat, Search for Extraterrestrial Intelligence, self-driving car, Silicon Valley, Simon Singh, Steve Ballmer, Steve Jobs, Steven Levy, Stewart Brand, Thomas Kuhn: the structure of scientific revolutions, Thomas Malthus, Upton Sinclair, Vilfredo Pareto, We wanted flying cars, instead we got 140 characters, Whole Earth Catalog, women in the workforce, Yogi Berra
As one study shows, National Football League (NFL) coaches change their lineup after a one-point loss, but don’t change it after a one-point win—even though these minor score differences are often poor indicators of player performance.42 Most of us act like American football coaches, treating success and failure as binary outcomes. But we don’t live in a binary world. The line between success and failure is often razor thin. “Failure hovers uncomfortably close to greatness,” wrote James Watson, the codiscoverer of DNA’s double-helix structure.43 The same decision that produced a failure in one scenario can lead to triumph in others. The goal, then, is to focus on the variables you can control—the inputs—instead of the outputs. You should ask, “What went wrong with this failure?” and if the inputs need fixing, you should fix them. But this question isn’t enough. You must also ask, “What went right with this failure?” You should retain the good-quality decisions, even if they produced a failure.
Plutocrats: The Rise of the New Global Super-Rich and the Fall of Everyone Else by Chrystia Freeland
activist fund / activist shareholder / activist investor, Albert Einstein, algorithmic trading, assortative mating, banking crisis, barriers to entry, Basel III, battle of ideas, Bernie Madoff, Big bang: deregulation of the City of London, Black Swan, Boris Johnson, Branko Milanovic, Bretton Woods, BRICs, business climate, call centre, carried interest, Cass Sunstein, Clayton Christensen, collapse of Lehman Brothers, commoditize, conceptual framework, corporate governance, creative destruction, credit crunch, Credit Default Swap, crony capitalism, Deng Xiaoping, disruptive innovation, don't be evil, double helix, energy security, estate planning, experimental subject, financial deregulation, financial innovation, Flash crash, Frank Gehry, Gini coefficient, global village, Goldman Sachs: Vampire Squid, Gordon Gekko, Guggenheim Bilbao,