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Longer titles found: Phosphorylation cascade (view), Oxidative phosphorylation (view), Protein phosphorylation (view), Substrate-level phosphorylation (view), Dephosphorylation (view), Autophosphorylation (view), Tyrosine phosphorylation (view)

searching for Phosphorylation 265 found (6259 total)

alternate case: phosphorylation

RELA (6,507 words) [view diff] exact match in snippet view article find links to article

cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications

RPS6KA5 (1,142 words) [view diff] exact match in snippet view article find links to article

gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes. RPS6KA5

Ribosomal protein S6 (378 words) [view diff] exact match in snippet view article find links to article

therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation

Smooth muscle (4,737 words) [view diff] exact match in snippet view article find links to article

reductions in crossbridge phosphorylation, a process termed force suppression. This process is mediated by the phosphorylation of the small heat shock protein

CAMK2G (1,113 words) [view diff] exact match in snippet view article find links to article

1016/S0021-9258(18)48406-2. PMID 1309762. Ikebe M, Reardon S (1990). "Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent

MARK1 (957 words) [view diff] exact match in snippet view article find links to article

regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262". J. Biol. Chem. 270 (13):

MAPKAPK2 (1,726 words) [view diff] exact match in snippet view article find links to article

Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase

Protein kinase D1 (1,304 words) [view diff] exact match in snippet view article find links to article

(1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue

HMGN1 (1,019 words) [view diff] exact match in snippet view article find links to article

Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction

MTOR (12,661 words) [view diff] exact match in snippet view article find links to article

affecting metabolism and survival. Phosphorylation of Akt's serine residue Ser473 by mTORC2 stimulates Akt phosphorylation on threonine residue Thr308 by

Aurora kinase B (4,535 words) [view diff] exact match in snippet view article find links to article

Aurora B. The phosphorylation of CENP-A by Aurora B reaches a maximum in prometaphase. In fact, Aurora A targets the same CENP-A phosphorylation site as Aurora

Protein kinase D1 (1,304 words) [view diff] exact match in snippet view article find links to article

(1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue

RPS6KA1 (1,456 words) [view diff] exact match in snippet view article find links to article

PMC 1169932. PMID 9214631. Roux PP, Richards SA, Blenis J (Jul 2003). "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated

Pyruvate kinase (4,042 words) [view diff] exact match in snippet view article find links to article

kinase) before it was recognized that it did not directly catalyze phosphorylation of pyruvate, which does not occur under physiological conditions. Pyruvate

Protein kinase N1 (1,759 words) [view diff] exact match in snippet view article find links to article

(January 2002). "Pathological shear stress stimulates the tyrosine phosphorylation of alpha-actinin associated with the glycoprotein Ib-IX complex". Biochemistry

AKT1 (2,803 words) [view diff] exact match in snippet view article find links to article

Downward J, Roberts TM, Avraham H (Nov 1999). "Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer

Glycogen synthase (1,749 words) [view diff] exact match in snippet view article find links to article

approximately 80 kDa, uses UDP-glucose as a sugar donor, and is regulated by phosphorylation and ligand binding. The second family (GT5), which is from bacteria

Protein kinase B (3,831 words) [view diff] exact match in snippet view article find links to article

kinase-2 (MAPKAPK2) can also serve as PDK2. Phosphorylation by mTORC2 stimulates the subsequent phosphorylation of Akt isoforms by PDPK1. Activated Akt isoforms

Cyclin-dependent kinase 4 (3,555 words) [view diff] exact match in snippet view article find links to article

cell cycle. CDK4 regulates the G1/S transition by contributing to the phosphorylation of retinoblastoma (RB) protein, which leads to the release of protein

Janus kinase 3 (5,166 words) [view diff] exact match in snippet view article find links to article

interactions between Jak3 and cytoskeletal proteins where tyrosine phosphorylation of the SH2 domain acted as an intramolecular switch for the interactions

MAPK8 (1,781 words) [view diff] exact match in snippet view article find links to article

stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". J. Biol. Chem. 270 (13): 7420–6. doi:10

Elongation factor 2 kinase (893 words) [view diff] exact match in snippet view article find links to article

eEF-2K is eEF-2. Phosphorylation of eEF-2 at Thr-56 by eEF-2K leads to inhibition of the elongation phase of protein synthesis. Phosphorylation of Thr-56 is

TTK (gene) (835 words) [view diff] exact match in snippet view article

of primary structure and classification of family members". Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, Antibodies, Functional

PHKG1 (1,036 words) [view diff] exact match in snippet view article find links to article

regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262". J. Biol. Chem. 270 (13):

EIF-2 kinase (181 words) [view diff] exact match in snippet view article find links to article

(PEK/PERK) EIF2AK4: also known as GCN2 These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized

RPS6KA2 (1,058 words) [view diff] exact match in snippet view article find links to article

polypeptide 2". Roux PP, Richards Stephanie A, Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated

PSKH1 (401 words) [view diff] exact match in snippet view article find links to article

Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization"

EIF2A (1,000 words) [view diff] exact match in snippet view article find links to article

hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha". Molecular and Cellular

TNK2 (1,756 words) [view diff] exact match in snippet view article find links to article

active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript

PRKG1 (1,307 words) [view diff] exact match in snippet view article find links to article

Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC (Jun 1992). "Phosphorylation of the cystic fibrosis transmembrane conductance regulator". The Journal

Janus kinase 2 (3,166 words) [view diff] exact match in snippet view article find links to article

transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation". The Journal of Experimental Medicine. 193 (2): 263–9. doi:10.1084/jem

Glycoprotein (2,653 words) [view diff] exact match in snippet view article find links to article

reciprocal to phosphorylation and the functions of these are likely to be an additional regulatory mechanism that controls phosphorylation-based signalling

TNNT2 (4,857 words) [view diff] exact match in snippet view article find links to article

Thr197, Ser201, Thr206, Ser208 and Thr287 in the C-terminal region. Phosphorylation of Thr206 alone was sufficient to reduce myofilament calcium sensitivity

DYRK1B (894 words) [view diff] exact match in snippet view article find links to article

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene. DYRK1B is a member of the DYRK

MKNK1 (1,031 words) [view diff] exact match in snippet view article find links to article

Waskiewicz AJ, et al. (2004). "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk"

Chloride potassium symporter 5 (3,100 words) [view diff] exact match in snippet view article find links to article

conventionally thought that phosphorylation inactivates or downregulates KCC2, however there is recent evidence to suggest that phosphorylation at different sites

Hepatitis C virus nonstructural protein 5A (1,179 words) [view diff] exact match in snippet view article find links to article

responsible for NS5A hyper-phosphorylation. An array of phosphorylation-specific antibodies confirmed their phosphorylation in infected cells. It has been

C-Raf (8,674 words) [view diff] exact match in snippet view article find links to article

protein tyrosine kinases, the activity of TKLs is restricted to the phosphorylation of serine and threonine residues within target proteins. The most important

FER (gene) (968 words) [view diff] exact match in snippet view article

Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases"

GFM1 (622 words) [view diff] exact match in snippet view article find links to article

this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene

EEF2K (1,651 words) [view diff] exact match in snippet view article find links to article

4884. PMC 24600. PMID 9144159. Ryazanov AG, Spirin AS (Oct 1990). "Phosphorylation of elongation factor 2: a key mechanism regulating gene expression

MAP2K6 (1,596 words) [view diff] exact match in snippet view article find links to article

protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels". Molecular and Cellular Biology. 23 (9): 3079–90. doi:10.1128/MCB

Cyclin-dependent kinase 3 (771 words) [view diff] exact match in snippet view article find links to article

T, Ishida A, Kosaka C, et al. (1996). "Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated

AKT2 (1,489 words) [view diff] exact match in snippet view article find links to article

Cron P, Andjelković M, Hemmings BA (1997). "Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta". J. Biol. Chem

MAP3K12 (1,255 words) [view diff] exact match in snippet view article find links to article

leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated

EIF2AK3 (1,365 words) [view diff] exact match in snippet view article find links to article

inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation". The Journal of Biological Chemistry. 276 (45): 41620–41628. doi:10

CAMK1D (167 words) [view diff] exact match in snippet view article find links to article

phagocytosis phosphorylation negative regulation of apoptotic process regulation of dendrite development nervous system development protein phosphorylation positive

CREB (2,243 words) [view diff] exact match in snippet view article find links to article

CREB3L3 (CREB3L3) CREB3L4 (CREB3L4) CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca2+/calmodulin-dependent

STAT4 (1,895 words) [view diff] exact match in snippet view article find links to article

critical for specific binding to the cytokine receptor after tyrosine phosphorylation; 6. C-terminal transactivation domain – triggering the transcriptional

MAP3K11 (1,259 words) [view diff] exact match in snippet view article find links to article

Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231.

Transcription factor Jun (5,452 words) [view diff] exact match in snippet view article find links to article

activity. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-jun knockout is lethal

CAMK1D (167 words) [view diff] exact match in snippet view article find links to article

phagocytosis phosphorylation negative regulation of apoptotic process regulation of dendrite development nervous system development protein phosphorylation positive

Glycogen storage disease type VI (295 words) [view diff] no match in snippet view article find links to article

Glycogen storage disease type VI (GSD VI) is a type of glycogen storage disease caused by a deficiency in liver glycogen phosphorylase or other components

G protein-coupled receptor kinase 3 (2,012 words) [view diff] exact match in snippet view article find links to article

CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus". The Journal

Ryanodine receptor 2 (1,774 words) [view diff] exact match in snippet view article find links to article

(AKAP6, PRKACA, PRKACB, PRKACG,) (phosphorylation at serine position S2808 in rodents) CaMKII (via phosphorylation at serine positions S2808 and S2814

PTK2B (1,887 words) [view diff] exact match in snippet view article find links to article

regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium

PLK3 (1,212 words) [view diff] exact match in snippet view article find links to article

Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36.

STK38L (564 words) [view diff] exact match in snippet view article find links to article

SJ, et al. (2004). "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein". J. Biol. Chem. 279 (22): 23806–12

RPS6KA4 (646 words) [view diff] exact match in snippet view article find links to article

promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene. 19 (54): 6324–6333

Cyclin-dependent kinase 6 (4,042 words) [view diff] exact match in snippet view article find links to article

activator needed by CDK6 is the phosphorylation in a conserved threonine residue located in 177 position, this phosphorylation is done by the cdk-activating

Tyrosine kinase 2 (2,850 words) [view diff] exact match in snippet view article find links to article

Mullersman J, et al. (December 1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2

AKT3 (1,189 words) [view diff] exact match in snippet view article find links to article

Hemmings BA (Apr 1999). "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain"

MYLK2 (777 words) [view diff] exact match in snippet view article find links to article

contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation". Cell. 107 (5): 631–41. doi:10.1016/S0092-8674(01)00586-4. PMID 11733062

MAPK4 (602 words) [view diff] exact match in snippet view article find links to article

signalling Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to

Kinase insert domain receptor (794 words) [view diff] exact match in snippet view article find links to article

Kinase 1). The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.

PRKCI (1,731 words) [view diff] exact match in snippet view article find links to article

3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1"

CDK12 (514 words) [view diff] exact match in snippet view article find links to article

Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

STK38 (706 words) [view diff] exact match in snippet view article find links to article

Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase". J. Biol. Chem. 278 (9): 6710–8. doi:10.1074/jbc

Cell division cycle 7-related protein kinase (1,746 words) [view diff] exact match in snippet view article find links to article

Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7". EMBO J. 16

MARK4 (852 words) [view diff] exact match in snippet view article find links to article

elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau protein in this disease. MARK4 has been shown to interact with

Β-Bungarotoxin (376 words) [view diff] exact match in snippet view article find links to article

blocks release of acetylcholine. It seems to do so by blocking the phosphorylation of MARCKS. It is thought that the dendrotoxin-like B chain acts first

PRKCI (1,731 words) [view diff] exact match in snippet view article find links to article

3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1"

STK38 (706 words) [view diff] exact match in snippet view article find links to article

Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase". J. Biol. Chem. 278 (9): 6710–8. doi:10.1074/jbc

STAT3 (3,340 words) [view diff] exact match in snippet view article find links to article

transcription activator. Specifically, STAT3 becomes activated after phosphorylation of tyrosine 705 in response to such ligands as interferons, epidermal

CHEK1 (3,340 words) [view diff] exact match in snippet view article find links to article

four Ser/Gln residues. Chk 1 activation occurs primarily through the phosphorylation of the conserved sites, Ser-317, Ser-345 and less often at Ser-366

CDK-activating kinase (1,140 words) [view diff] exact match in snippet view article find links to article

In mammals, activating phosphorylation by CAK can only occur once cyclin is bound. In budding yeast, activating phosphorylation by CAK can take place before

Cell cycle checkpoint (4,581 words) [view diff] exact match in snippet view article find links to article

complex. This complex is known to inactivate Rb by phosphorylation. However, the details of Rb phosphorylation are quite complex and specific compared to previous

Deoxycytidine kinase (2,519 words) [view diff] exact match in snippet view article find links to article

phosphorylation of serine 74 (Ser74) on dCK causes a change in enzyme conformation and influences enzyme kinetics. More specifically, phosphorylation

PRKCQ (2,407 words) [view diff] exact match in snippet view article find links to article

also initiates the assembly of proteins Carma-1, Bcl-10 and Malt-1 by phosphorylation of Carma-1. This complex of three proteins activates the transcription

SGK3 (1,022 words) [view diff] exact match in snippet view article find links to article

PMID 9373149. Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A"

BCKDHB (1,011 words) [view diff] exact match in snippet view article find links to article

catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site". J. Biol. Chem. 278 (44): 43402–10

PRKD2 (940 words) [view diff] exact match in snippet view article find links to article

Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

CAMK2D (872 words) [view diff] exact match in snippet view article find links to article

Hertog J, Vandenheede JR, et al. (1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function". EMBO J. 12 (10): 3903–11

PAK2 (2,256 words) [view diff] exact match in snippet view article find links to article

glucose uptake. PAK2-mediated phosphorylation of merlin at S518 modulates its tumor suppressor activity, c-Jun phosphorylation at T2, T8, T89, T93 and T286

TNNI3 (3,119 words) [view diff] exact match in snippet view article find links to article

has been determined. Phosphorylation: cTnI was the first sarcomeric protein identified to be a substrate of PKA. Phosphorylation of cTnI at Ser23/Ser24

MAP2K4 (1,031 words) [view diff] exact match in snippet view article find links to article

"Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation". The Journal of Biological Chemistry. 277 (4): 2573–8. doi:10.1074/jbc

Epidermal growth factor receptor (6,879 words) [view diff] exact match in snippet view article find links to article

There are several quantitative methods available that use protein phosphorylation detection to identify EGFR family inhibitors. New drugs such as osimertinib

Cyclin D (4,605 words) [view diff] exact match in snippet view article find links to article

Cdk1 and Cdk2 respectively to create complexes that continue with Rb phosphorylation. Cyclin A and E dependent kinase complexes also function to inhibit

STK11 (2,831 words) [view diff] exact match in snippet view article find links to article

androgen receptor and consequently reduced the activation of AMPK by phosphorylation. In contrast, 17β-estradiol treatment increased LKB1 mRNA, an effect

Guanylate kinase (657 words) [view diff] exact match in snippet view article find links to article

in purine metabolism. Guanylate kinase catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly,

KCNC4 (677 words) [view diff] exact match in snippet view article find links to article

TB (1995). "Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate". Neuron. 13 (6): 1403–12. doi:10.1016/0896-6273(94)90425-1

Sleep debt (1,918 words) [view diff] exact match in snippet view article find links to article

phosphorylated during waking hours, and are dephosphorylated during sleep. The phosphorylation is aided by the gene Sik3. A type of laboratory mouse (named Sleepy)

Leukemia inhibitory factor (1,583 words) [view diff] exact match in snippet view article find links to article

peptidyl-serine phosphorylation of STAT protein positive regulation of MAPK cascade positive regulation of peptidyl-serine phosphorylation spongiotrophoblast

CDK13 (1,169 words) [view diff] exact match in snippet view article find links to article

Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography

FAM20C (827 words) [view diff] exact match in snippet view article find links to article

secretory kinase, responsible for the phosphorylation of all secreted proteins, from milk to bone proteins. Phosphorylation by Fam20C in the secretory pathway

PKN2 (1,269 words) [view diff] exact match in snippet view article find links to article

PMID 11356191. Hodgkinson CP, Sale GJ (2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment". Biochemistry

ZAP70 (2,769 words) [view diff] exact match in snippet view article find links to article

Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes". Frontiers in Immunology. 8: 789. doi:10.3389/fimmu

STK11 (2,831 words) [view diff] exact match in snippet view article find links to article

androgen receptor and consequently reduced the activation of AMPK by phosphorylation. In contrast, 17β-estradiol treatment increased LKB1 mRNA, an effect

DAPK2 (695 words) [view diff] exact match in snippet view article find links to article

Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

MAST1 (405 words) [view diff] exact match in snippet view article find links to article

Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

Cyclin B1 (3,276 words) [view diff] exact match in snippet view article find links to article

regulated by the phosphorylation of cyclin B1, in contrast to phosphorylation of Cdk1 regulating the activity of the complex. Phosphorylation of cyclin B1

Tyrosine-protein kinase SYK (2,083 words) [view diff] exact match in snippet view article find links to article

separated by a linker domain. However, activation of SYK relies less on phosphorylation by Src family kinases than ZAP70. SYK and ZAP70 share a common evolutionary

TGF beta receptor 2 (960 words) [view diff] exact match in snippet view article find links to article

apoptotic process pathway-restricted SMAD protein phosphorylation common-partner SMAD protein phosphorylation bronchus morphogenesis lung development response

MAST2 (881 words) [view diff] exact match in snippet view article find links to article

ML, Pero R, Byreddy DV, Tavtigian SV, Bartel PL (2000). "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ

Related to receptor tyrosine kinase (893 words) [view diff] exact match in snippet view article find links to article

belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of

FYN (4,778 words) [view diff] exact match in snippet view article find links to article

targets involved in a variety of different signaling pathways. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein

MAP2K1 (1,478 words) [view diff] exact match in snippet view article find links to article

Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels". Mol. Cell. Biol. 23 (9). United States: 3079–90. doi:10.1128/MCB

LIMK2 (1,114 words) [view diff] exact match in snippet view article find links to article

Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (Jun 1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization"

TGF beta 1 (2,290 words) [view diff] exact match in snippet view article find links to article

tolerance induction to self antigen positive regulation of protein phosphorylation endoderm development response to cholesterol positive regulation of

PRKD3 (1,073 words) [view diff] exact match in snippet view article find links to article

(1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue

Janus kinase 1 (2,423 words) [view diff] exact match in snippet view article find links to article

beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation". Mol. Cell. Biol. 18 (11): 6416–22. doi:10.1128/mcb.18.11.6416. PMC 109227

PRKACG (1,051 words) [view diff] exact match in snippet view article find links to article

Jayaraman T, Burkhoff D, Rosemblit N, Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor):

MAPK3 (1,140 words) [view diff] exact match in snippet view article find links to article

11693. PMID 10206983. Roux PP, Richards SA, Blenis J (July 2003). "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated

ATF1 (1,380 words) [view diff] exact match in snippet view article find links to article

stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances

EIF4E (8,382 words) [view diff] exact match in snippet view article find links to article

eIF4E. Although eIF4E phosphorylation and translation rates are not always correlated, consistent patterns of eIF4E phosphorylation are observed throughout

CHUK (2,765 words) [view diff] exact match in snippet view article find links to article

alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation". J Biol Chem. 280 (40): 33945–52. doi:10.1074/jbc.M506206200. PMID 16103118

KIT (gene) (4,117 words) [view diff] exact match in snippet view article

"Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk". Experimental Cell Research

T-cell receptor (5,372 words) [view diff] exact match in snippet view article find links to article

intermediate "proofreading" steps can be multiple rounds of tyrosine phosphorylation. These steps require energy and therefore do not happen spontaneously

DAPK3 (843 words) [view diff] exact match in snippet view article find links to article

U, Landsberg G, Scheidtmann KH (Feb 2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Research

Efraim Racker (832 words) [view diff] exact match in snippet view article find links to article

synthesize ATP. Racker and his co-workers concluded that oxidative phosphorylation could be restored by addition of the supernatant from the centrifuging

Pepstatin (409 words) [view diff] exact match in snippet view article find links to article

analysis indicated that the phosphorylation of ERK was inhibited in pepstatin A-treated cells, while the phosphorylation of IκB and Akt showed almost

EEF2 (1,045 words) [view diff] exact match in snippet view article find links to article

the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation. aEF2/eEF2 found in most archaea and eukaryotes, including humans,

PRKACA (1,681 words) [view diff] exact match in snippet view article find links to article

cancer. It has been speculated that abnormally high levels of PKA phosphorylation contributes to heart disease. This affects excitation-contraction coupling

MAPK12 (938 words) [view diff] exact match in snippet view article find links to article

Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

EIF4E (8,382 words) [view diff] exact match in snippet view article find links to article

eIF4E. Although eIF4E phosphorylation and translation rates are not always correlated, consistent patterns of eIF4E phosphorylation are observed throughout

Mitogen-activated protein kinase 9 (792 words) [view diff] exact match in snippet view article find links to article

specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes & Development. 8 (24): 2996–3007. doi:10.1101/gad.8.24.2996

ADF/Cofilin family (1,907 words) [view diff] exact match in snippet view article find links to article

helping cell to maintain ATP-G-actin pool for sustained motility. pH, phosphorylation and phosphoinositides regulate cofilin's binding and associating activity

SH3BP2 (89 words) [view diff] exact match in snippet view article find links to article

the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. It is also associated with cherubism. SH3 domain

EEF2 (1,045 words) [view diff] exact match in snippet view article find links to article

the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation. aEF2/eEF2 found in most archaea and eukaryotes, including humans,

Angiopoietin 1 (1,623 words) [view diff] exact match in snippet view article find links to article

glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between

PKC alpha (2,643 words) [view diff] exact match in snippet view article find links to article

its role in liver tissue involves the effects of bile acids on the phosphorylation mechanism of the PKC family of proteins. Past research has affirmed

Megakaryocyte-associated tyrosine kinase (1,177 words) [view diff] exact match in snippet view article find links to article

terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought

G2 phase (2,818 words) [view diff] exact match in snippet view article find links to article

begins at the end of S phase after DNA replication, in response to phosphorylation of transcription factors such as NF-Y, FoxM1 and B-Myb by upstream

Hsp70 (5,682 words) [view diff] exact match in snippet view article find links to article

domain. Protein phosphorylation, a post-translational modification, helps to regulate protein function and involves the phosphorylation of amino acids

Phosphatidylinositol (3,4,5)-trisphosphate (779 words) [view diff] exact match in snippet view article

product of the class I phosphoinositide 3-kinases' (PI 3-kinases) phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2). It is a phospholipid

Mucin short variant S1 (2,926 words) [view diff] exact match in snippet view article find links to article

of MUC1 in fibroblasts increased the phosphorylation of Akt. Phosphorylation of Akt results in phosphorylation of Bcl-2-associated death promoter. This

Histone H2B (1,731 words) [view diff] exact match in snippet view article find links to article

modifications include acetylation, methylation, phosphorylation, ubiquitination, and sumoylation. Acetylation, phosphorylation, and ubiquitination are the most common

ERBB4 (1,597 words) [view diff] exact match in snippet view article find links to article

to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4". Oncogene

CD135 (1,727 words) [view diff] exact match in snippet view article find links to article

proximity to each other, eliciting initial trans-phosphorylation of each kinase domain. This initial phosphorylation event further activates the intrinsic tyrosine

RPTOR (3,504 words) [view diff] exact match in snippet view article find links to article

upregulated by mTOR and MPAK8 by insulin-stimulated phosphorylation at Ser-863. MAPK8 also causes phosphorylation at Ser-696, Thr-706, and Ser-863 as a result

PIM1 (2,973 words) [view diff] exact match in snippet view article find links to article

of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function

CDCP1 (1,079 words) [view diff] exact match in snippet view article find links to article

tyrosine residues - Y707, Y734, Y743, Y762 and Y806. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach

CTP synthetase (1,977 words) [view diff] exact match in snippet view article find links to article

uridine salvage pathways. The reaction proceeds by the ATP-dependent phosphorylation of UTP on the 4-oxygen atom, making the 4-carbon electrophilic and

TGF beta receptor 1 (1,618 words) [view diff] exact match in snippet view article find links to article

regulation of protein ubiquitination post-embryonic development protein phosphorylation negative regulation of chondrocyte differentiation mesenchymal cell

C5a receptor (1,767 words) [view diff] exact match in snippet view article find links to article

β-arrestin2 recruitment via Rab5a, coupling of Gαi proteins, ERK1/2 phosphorylation, calcium mobilization and Rho activation leading to downstream functions

Necroptosis (1,667 words) [view diff] exact match in snippet view article find links to article

which recruits RIPK3 forming the necrosome also named ripoptosome. Phosphorylation of MLKL by the ripoptosome drives oligomerization of MLKL, allowing

SoRI-20041 (274 words) [view diff] exact match in snippet view article find links to article

interfering in the flow of release of dopamine from amphetaminergic phosphorylation at the affected transporter. This overcomes the obstacle of a compromised

Thymopoietin (1,434 words) [view diff] exact match in snippet view article find links to article

binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms

Inositol phosphate (516 words) [view diff] exact match in snippet view article find links to article

(IP6) also known as phytic acid, or phytate (as a salt). A series of phosphorylation and dephosphorylation reactions are carried out by at least 19 phosphoinositide

BRSK2 (493 words) [view diff] exact match in snippet view article find links to article

"BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260". Biochemical and Biophysical Research Communications. 347

Protein c-Fos (3,991 words) [view diff] exact match in snippet view article find links to article

activity is also regulated by posttranslational modification caused by phosphorylation by different kinases, like MAPK, CDC2, PKA or PKC which influence protein

Protein c-Fos (3,991 words) [view diff] exact match in snippet view article find links to article

activity is also regulated by posttranslational modification caused by phosphorylation by different kinases, like MAPK, CDC2, PKA or PKC which influence protein

C5a receptor (1,767 words) [view diff] exact match in snippet view article find links to article

β-arrestin2 recruitment via Rab5a, coupling of Gαi proteins, ERK1/2 phosphorylation, calcium mobilization and Rho activation leading to downstream functions

Inositol phosphate (516 words) [view diff] exact match in snippet view article find links to article

(IP6) also known as phytic acid, or phytate (as a salt). A series of phosphorylation and dephosphorylation reactions are carried out by at least 19 phosphoinositide

MELK (977 words) [view diff] exact match in snippet view article find links to article

Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

MAP2K2 (1,231 words) [view diff] exact match in snippet view article find links to article

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this

Phosphofructokinase 2 (4,253 words) [view diff] exact match in snippet view article find links to article

covalent modification through phosphorylation/dephosphorylation based on the cell's hormonal signaling. Phosphorylation of a specific residue may prompt

PDGFB (434 words) [view diff] exact match in snippet view article find links to article

positive regulation of protein tyrosine kinase activity peptidyl-tyrosine phosphorylation positive regulation of cell division heart development positive regulation

CAMK2B (1,157 words) [view diff] exact match in snippet view article find links to article

MJ, Rosenstein AJ, Min KT, Kennedy MB (1997). "Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B

Protein kinase C zeta type (2,666 words) [view diff] exact match in snippet view article find links to article

S2CID 11200668. Serrano P, Yao Y, Sacktor TC (2005). "Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation"

MYLK4 (330 words) [view diff] exact match in snippet view article find links to article

ADP + a phosphoprotein. MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule. Not very

DCLK1 (649 words) [view diff] exact match in snippet view article find links to article

of protein localization to nucleus peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction neuron projection

MAP3K2 (1,505 words) [view diff] exact match in snippet view article find links to article

protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase"

CD79A (2,434 words) [view diff] exact match in snippet view article find links to article

short cytoplasmic domain. The cytoplasmic domain contains multiple phosphorylation sites including a conserved dual phosphotyrosine binding motif, termed

PDGFRB (3,403 words) [view diff] exact match in snippet view article find links to article

conformations due to auto-phosphorylation of regulatory tyrosine residues in trans fashion. Tyrosine residues 857 and 751 are major phosphorylation sites for the

Troponin I (2,156 words) [view diff] exact match in snippet view article find links to article

monitoring of human cTnI has revealed that there are 14 phosphorylation sites and the pattern of phosphorylation observed at these sites is changed in response

JADE1 (6,055 words) [view diff] exact match in snippet view article find links to article

kinase pathway. JADE1 is a target of phosphorylation by Casein kinase 2 (CK2). In addition, multiple phosphorylation sites are found by high throughput

TSSK2 (414 words) [view diff] exact match in snippet view article find links to article

differentiation intracellular signal transduction phosphorylation multicellular organism development protein phosphorylation spermatogenesis spermatid development

PFKP (929 words) [view diff] exact match in snippet view article find links to article

Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046

ROCK2 (213 words) [view diff] exact match in snippet view article find links to article

protein phosphorylation intracellular signal transduction regulation of actin cytoskeleton organization centrosome duplication phosphorylation rhythmic

Bcl-2 (4,567 words) [view diff] exact match in snippet view article find links to article

Haldar S, Reed JC (2001). "Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1". Neoplasia. 3 (6): 550–559. doi:10.1038/sj

Interleukin-23 receptor (1,589 words) [view diff] exact match in snippet view article find links to article

domain and an intracellular part that contains three potential tyrosine phosphorylation domains. There are 24 IL23R splice variants in mitogen-activated lymphocytes

Chemical modification (1,476 words) [view diff] exact match in snippet view article find links to article

fluctuating needs of the organism. Common chemical modifications include phosphorylation, glycosylation, ubiquitination, methylation, lipidation, and proteolysis

LATS2 (746 words) [view diff] exact match in snippet view article find links to article

Yabuta N, Hosomi T, et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383–97. doi:10.1111/j

MAPK11 (1,233 words) [view diff] exact match in snippet view article find links to article

cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor

EIF4G3 (1,088 words) [view diff] exact match in snippet view article find links to article

Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor

MAP3K9 (462 words) [view diff] exact match in snippet view article find links to article

"Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop". Biochemistry. 43 (51): 16348–55. doi:10.1021/bi049866y

MARK3 (1,217 words) [view diff] exact match in snippet view article find links to article

"Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation". J. Cell Sci. 119 (Pt 19): 4059–70. doi:10.1242/jcs.03097. PMID 16968750

EIF4EBP1 (2,696 words) [view diff] exact match in snippet view article find links to article

cap-dependent translation by binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent

CD79A (2,434 words) [view diff] exact match in snippet view article find links to article

short cytoplasmic domain. The cytoplasmic domain contains multiple phosphorylation sites including a conserved dual phosphotyrosine binding motif, termed

PTPN6 (2,292 words) [view diff] exact match in snippet view article find links to article

PMID 11551923. Greer SF, Justement LB (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1"

60S ribosomal protein L12 (739 words) [view diff] exact match in snippet view article find links to article

Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046

MARK2 (1,143 words) [view diff] exact match in snippet view article find links to article

Biological process cell differentiation intracellular signal transduction phosphorylation mitochondrion localization neuron migration Wnt signaling pathway regulation

MAP3K13 (451 words) [view diff] exact match in snippet view article find links to article

cytoplasm IkappaB kinase complex Biological process phosphorylation JNK cascade protein phosphorylation protein autophosphorylation positive regulation of

Tyrosin-protein kinase Lck (4,466 words) [view diff] exact match in snippet view article find links to article

acts as a scaffold able to regulate the TCR proximal signals in a phosphorylation-dependent manner. The most important proteins recruited by phosphorylated

TSSK2 (414 words) [view diff] exact match in snippet view article find links to article

differentiation intracellular signal transduction phosphorylation multicellular organism development protein phosphorylation spermatogenesis spermatid development

Glucose 6-phosphate (966 words) [view diff] exact match in snippet view article find links to article

other organisms. Within a cell, glucose 6-phosphate is produced by phosphorylation of glucose on the sixth carbon. This is catalyzed by the enzyme hexokinase

CDC2L1 (1,066 words) [view diff] exact match in snippet view article find links to article

1242/jcs.111.11.1495. PMID 9580558. Tang D, Gururajan R, Kidd VJ (1998). "Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during

ELK3 (899 words) [view diff] exact match in snippet view article find links to article

serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor

MYBL2 (1,486 words) [view diff] exact match in snippet view article find links to article

M, Saville MK, Watson RJ (June 2001). "Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions

MAP2K5 (1,243 words) [view diff] exact match in snippet view article find links to article

Campbell DG, Morrice N, Peggie M, Cohen P (Jun 2003). "An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5)

ERF (gene) (737 words) [view diff] exact match in snippet view article

activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". The EMBO Journal. 14

Cofilin-2 (1,116 words) [view diff] exact match in snippet view article find links to article

Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals

EEF1D (1,395 words) [view diff] exact match in snippet view article find links to article

Retrieved 16 May 2014. Venema RC, Peters HI, Traugh JA (Jul 1991). "Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein

MAP3K10 (1,089 words) [view diff] exact match in snippet view article find links to article

DNA-binding transcription factor activity protein phosphorylation JNK cascade peptidyl-serine phosphorylation protein autophosphorylation smoothened signaling

PTK6 (999 words) [view diff] exact match in snippet view article find links to article

enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation". Oncogene. 19 (48): 5471–6. doi:10.1038/sj.onc.1203931. PMID 11114724

Phosphorylase (375 words) [view diff] exact match in snippet view article find links to article

more active R form of glycogen phosphorylase that is derived from the phosphorylation of the less active R form, phosphorylase b with associated AMP. The

GABRB1 (1,113 words) [view diff] exact match in snippet view article find links to article

"Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S

RPS6KC1 (505 words) [view diff] exact match in snippet view article find links to article

C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j

PFN2 (1,117 words) [view diff] exact match in snippet view article find links to article

Hüttelmaier S, Schluter K, Jockusch B M, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction

PTPN11 (4,304 words) [view diff] exact match in snippet view article find links to article

Helicobacter pylori into gastric epithelia. Once activated by SRC phosphorylation, CagA binds to SHP2, allosterically activating it. This leads to morphological

PTPRJ (1,340 words) [view diff] exact match in snippet view article find links to article

regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells

Phosphoinositide-dependent kinase-1 (2,127 words) [view diff] exact match in snippet view article find links to article

however does not require membrane lipid binding for the efficient phosphorylation of most of its substrates in the cytosol (not at the cell membrane)

PFN2 (1,117 words) [view diff] exact match in snippet view article find links to article

Hüttelmaier S, Schluter K, Jockusch B M, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction

KSR1 (553 words) [view diff] exact match in snippet view article find links to article

functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1". Exp. Cell Res. 317 (4): 452–63. doi:10.1016/j.yexcr.2010

FLT4 (1,183 words) [view diff] exact match in snippet view article find links to article

(November 2001). "Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell

Cyclin-dependent kinase 9 (1,460 words) [view diff] exact match in snippet view article find links to article

PMID 12037672. Kim YK, Bourgeois CF, Isel C, Churcher MJ, Karn J (July 2002). "Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly

Serine/arginine-rich splicing factor 1 (2,574 words) [view diff] exact match in snippet view article find links to article

nucleus is dependent on its phosphorylation state; dephosphorylation of ASF/SF2 facilitates binding to TAP, while phosphorylation directs ASF/SF2 to nuclear

Protein kinase domain (1,562 words) [view diff] exact match in snippet view article find links to article

enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including

Interleukin-10 receptor (502 words) [view diff] exact match in snippet view article find links to article

fully dysfunctional receptors, and others being incapable of accepting phosphorylation. Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (February 1994)

PTPRJ (1,340 words) [view diff] exact match in snippet view article find links to article

regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells

CDKL2 (456 words) [view diff] exact match in snippet view article find links to article

Peters KL, Elco CP, et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol

BCKDHA (2,092 words) [view diff] exact match in snippet view article find links to article

Eisenstein RS, Hoganson G, Miller RH, Harper AE (1991). "Altered phosphorylation state of branched-chain 2-oxo acid dehydrogenase in a branched-chain

Fibroblast growth factor receptor 4 (1,291 words) [view diff] exact match in snippet view article find links to article

transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation". Cell. 82 (2): 241–50. doi:10.1016/0092-8674(95)90311-9. PMID 7543024

HCK (2,331 words) [view diff] exact match in snippet view article find links to article

c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation". Cell. 105 (1): 115–126. doi:10.1016/S0092-8674(01)00301-4. PMID 11301007

Sarcoplasmic reticulum (1,810 words) [view diff] exact match in snippet view article find links to article

protein kinase A (PKA). PKA can add a phosphate to PLB (this is known as phosphorylation), preventing it from inhibiting SERCA and allowing for muscle relaxation

PTPRA (1,333 words) [view diff] exact match in snippet view article find links to article

PMC 450243. PMID 8670803. den Hertog J, Tracy S, Hunter T (July 1994). "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding

SNF1LK2 (676 words) [view diff] exact match in snippet view article find links to article

Muraoka M, Nonaka Y, Okamoto M (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic

PHKG2 (910 words) [view diff] exact match in snippet view article find links to article

cellular component Biological process phosphorylation generation of precursor metabolites and energy protein phosphorylation glycogen biosynthetic process positive

MAP3K1 (3,171 words) [view diff] exact match in snippet view article find links to article

Mitogen-activated protein kinase kinases (MAP2Ks) are substrates for direct phosphorylation by the MAP3K1 protein kinase. The MAP3K1 kinase domain may also be

Light-harvesting complexes of green plants (603 words) [view diff] exact match in snippet view article find links to article

with adhesion of granal membranes and photo-regulated by reversible phosphorylation of its threonine residues. Both these processes are believed to mediate

Ribostamycin (440 words) [view diff] exact match in snippet view article find links to article

resistant bacteria contain enzymes that modify the structure through phosphorylation, adenylation, and acetylation and prevent the antibiotic from being

Citron kinase (2,469 words) [view diff] exact match in snippet view article find links to article

Matsumura F (May 2003). "Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II". Molecular Biology of the Cell

PKN3 (gene) (478 words) [view diff] exact match in snippet view article

process protein phosphorylation intracellular signal transduction peptidyl-serine phosphorylation epithelial cell migration phosphorylation signal transduction

Electron-capture dissociation (3,262 words) [view diff] exact match in snippet view article find links to article

restricting the location of five phosphorylation sites. It has advantages over CAD to measure the degree of phosphorylation with a minimum number of losses

EIF5 (895 words) [view diff] exact match in snippet view article find links to article

PMID 11331597. Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in

EIF3B (932 words) [view diff] exact match in snippet view article find links to article

preinitiation complex through dynamic protein interchange and ordered phosphorylation events". Cell. 123 (4): 569–80. doi:10.1016/j.cell.2005.10.024. PMID 16286006

PER2 (1,760 words) [view diff] exact match in snippet view article find links to article

mutation called tau has been discovered in the CK1e, which increases phosphorylation of homologous PER2 leading to a faster degradation and a shortened

LIMK1 (1,420 words) [view diff] exact match in snippet view article find links to article

Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization"

Caveolin 1 (1,555 words) [view diff] exact match in snippet view article find links to article

1996). "Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1". The Journal of Biological Chemistry

TSC1 (2,369 words) [view diff] exact match in snippet view article find links to article

sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner". Human Molecular Genetics. 15 (2): 287–97. doi:10

TXK (gene) (718 words) [view diff] exact match in snippet view article

937–42. PMID 8632917. Wardenburg JB, Fu C, Jackman JK, et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell

SGK2 (562 words) [view diff] exact match in snippet view article find links to article

transport protein phosphorylation intracellular signal transduction peptidyl-serine phosphorylation regulation of apoptotic process phosphorylation regulation

Cyclin-dependent kinase 10 (729 words) [view diff] exact match in snippet view article find links to article

cell cycle phosphorylation positive regulation of MAPK cascade negative regulation of cell population proliferation protein phosphorylation peptidyl-threonine

PTPRB (792 words) [view diff] exact match in snippet view article find links to article

vascular permeability. Recently, Soni et al. have shown that tyrosine phosphorylation of VE-PTP via Pyk2 kinase downstream of STIM1-induced calcium entry

CDC42 (3,700 words) [view diff] exact match in snippet view article find links to article

Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor

TEK tyrosine kinase (1,695 words) [view diff] exact match in snippet view article find links to article

protein phosphorylation response to hypoxia positive regulation of endothelial cell proliferation heart trabecula formation phosphorylation transmembrane

Epidermal growth factor (1,708 words) [view diff] exact match in snippet view article find links to article

cholesterol efflux peptidyl-tyrosine phosphorylation positive regulation of DNA binding positive regulation of phosphorylation positive regulation of mitotic

TSC1 (2,369 words) [view diff] exact match in snippet view article find links to article

sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner". Human Molecular Genetics. 15 (2): 287–97. doi:10

STYK1 (476 words) [view diff] exact match in snippet view article find links to article

differentiation protein phosphorylation innate immune response cell migration regulation of cell population proliferation phosphorylation chemotaxis cell adhesion

MAP3K8 (1,632 words) [view diff] exact match in snippet view article find links to article

Mollenauer MN, Xu Z, Turck CW, Weiss A (Aug 2002). "Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription"

Lim kinase (2,692 words) [view diff] exact match in snippet view article find links to article

through the phosphorylation of cofilin at Ser-3, inactivating its actin-depolymerizing activity. LIMK proteins are activated via phosphorylation at Thr508

3'-Phosphoadenosine-5'-phosphosulfate (427 words) [view diff] exact match in snippet view article find links to article

sulfation pathways. It is endogenously synthesized by organisms via the phosphorylation of adenosine 5′-phosphosulfate (APS), an intermediary metabolite. In

PASK (796 words) [view diff] exact match in snippet view article find links to article

domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation". J. Biol. Chem. 285 (52): 41034–43. doi:10.1074/jbc.M110.157594. PMC 3003402

Tyrosine-protein kinase Fes/Fps (577 words) [view diff] exact match in snippet view article find links to article

Afar DE, Shibuya M, Witte ON, Smithgall TE (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR

Cyclin-dependent kinase 10 (729 words) [view diff] exact match in snippet view article find links to article

cell cycle phosphorylation positive regulation of MAPK cascade negative regulation of cell population proliferation protein phosphorylation peptidyl-threonine

Herpesviridae (2,914 words) [view diff] exact match in snippet view article find links to article

that cmvIL-10 functions through phosphorylation of the Stat3 protein. It was originally thought that this phosphorylation was a result of the JAK-STAT pathway

Protein-histidine tele-kinase (199 words) [view diff] exact match in snippet view article find links to article

RA (1981). "Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance". Biochemistry

Presenilin-1 (3,113 words) [view diff] exact match in snippet view article find links to article

play a role in beta-catenin phosphorylation. Beta-catenin is coupled by presenilin-1 and undergoes a sequential phosphorylation by two kinase activities

TIE1 (339 words) [view diff] exact match in snippet view article find links to article

fusion response to retinoic acid phosphorylation in utero embryonic development vasculogenesis protein phosphorylation negative regulation of cell migration

EIF4B (957 words) [view diff] exact match in snippet view article find links to article

Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW (2004). "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated

GSK3A (212 words) [view diff] exact match in snippet view article find links to article

peptidyl-threonine phosphorylation cell migration negative regulation of TOR signaling positive regulation of peptidyl-serine phosphorylation cellular response

NUAK1 (808 words) [view diff] exact match in snippet view article find links to article

regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls

Zinc finger FYVE domain-containing protein 9 (237 words) [view diff] exact match in snippet view article find links to article

SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor

Charles David Allis (2,282 words) [view diff] exact match in snippet view article find links to article

also branched off to researching histone phosphorylation and histone methylation. He linked histone phosphorylation to mitosis and mitogen stimulation, and

EPH receptor B2 (614 words) [view diff] exact match in snippet view article find links to article

Pasquale EB (May 1998). "Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region". Oncogene. 16 (20):

Dephospho-(reductase kinase) kinase (411 words) [view diff] exact match in snippet view article

reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation". Biochem. Biophys. Res. Commun. 81 (4): 1268–77

MKNK2 (834 words) [view diff] exact match in snippet view article find links to article

nucleoplasm Biological process intracellular signal transduction phosphorylation protein phosphorylation cell surface receptor signaling pathway cellular response

Cyclin-dependent kinase 7 (2,347 words) [view diff] exact match in snippet view article find links to article

found to heavily downregulated CAK activity, resulting in decreased phosphorylation of both CDK2 and CTD by CDK7. Mutant p53 was unable to downregulate

LRRK2 (2,253 words) [view diff] exact match in snippet view article find links to article

dependent on LRRK2-mediated phosphorylation of NADPH oxidase 2 (NOX2). Specifically, LRRK2 activity promotes activatory phosphorylation of the p47phox subunit

BCR (gene) (1,541 words) [view diff] exact match in snippet view article

Afar DE, Shibuya M, Witte ON, Smithgall TE (February 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR

MCM4 (1,271 words) [view diff] exact match in snippet view article find links to article

DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and

Heat shock protein 90kDa alpha (cytosolic), member A1 (8,199 words) [view diff] exact match in snippet view article

Hsp90A. Phosphorylation of Hsp90 has been shown to have affect its binding to clients, co-chaperones and nucleotide. Specific phosphorylation of Hsp90A

GRIA1 (1,359 words) [view diff] exact match in snippet view article find links to article

Missale C, Cattabeni F, Di Luca M (November 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. 278 (45): 44745–44752

B-cell receptor (2,173 words) [view diff] exact match in snippet view article find links to article

tyrosine-phosphorylated receptor family. The binding event allows phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the associated