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searching for Bcl-2 240 found (454 total)

alternate case: bcl-2

Venetoclax (2,632 words) [view diff] exact match in snippet view article find links to article

throat infection and tiredness. Venetoclax attaches to a protein called Bcl-2. This protein is present in high amounts in CLL cancer cells, where it helps

BCL2L2 (1,552 words) [view diff] exact match in snippet view article find links to article

Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered

Small cleaved cells (276 words) [view diff] exact match in snippet view article find links to article

results in juxtaposition of the bcl-2 proto-oncogene with the heavy chain JH locus, and thus in overexpression of bcl-2. Bcl-2 is a well known anti-apoptotic

ATG12 (847 words) [view diff] exact match in snippet view article find links to article

promotes apoptosis through an interaction with anti-apoptotic members of the Bcl-2 family. GRCh38: Ensembl release 89: ENSG00000145782 – Ensembl, May 2017

BOK (gene) (1,782 words) [view diff] exact match in snippet view article

Bok (Bcl-2 related ovarian killer) is a protein-coding gene of the Bcl-2 family that is found in many invertebrates and vertebrates. It induces apoptosis

Mir-365 microRNA precursor family (888 words) [view diff] exact match in snippet view article find links to article

promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2". Carcinogenesis. 33 (1): 220–5. doi:10.1093/carcin/bgr245. PMID 22072615

FKBP8 (891 words) [view diff] exact match in snippet view article find links to article

Shirane M, Nakayama KI (2003). "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis". Nat. Cell Biol. 5 (1): 28–37. doi:10

Gingerol (2,832 words) [view diff] exact match in snippet view article find links to article

the anti-apoptotic Bcl-2 proteins on the surface of mitochondria, which in turn increases the capabilities for the pro-apoptotic Bcl-2 proteins to initiate

Karyorrhexis (1,555 words) [view diff] exact match in snippet view article find links to article

environmental factors such as oxidative stress signal pro-apoptotic members of the Bcl-2 protein family to eventually break the outer membrane of the mitochondria

MTCH2 (910 words) [view diff] exact match in snippet view article find links to article

the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID. MTCH2 assists in the recruitment of BID into the mitochondria

Eurico Carrapatoso (1,592 words) [view diff] no match in snippet view article find links to article

orchestra Opus: 60 Duration (minutes) 120 Instrumentation: 1(picc).1(ca).2(bcl).2(cbsn) - 4hn. 1 - perc(1) - timp - harp - strings (some basses with C extension)

MOAP1 (617 words) [view diff] exact match in snippet view article find links to article

interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with

BAG1 (1,637 words) [view diff] exact match in snippet view article find links to article

Reed JC (March 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell. 80 (2): 279–84. doi:10

Obatoclax (616 words) [view diff] exact match in snippet view article find links to article

lymphoma, myelofibrosis, and mastocytosis. Obatoclax is an inhibitor of the Bcl-2 family of proteins. This inhibition induces apoptosis in cancer cells, preventing

Senolytic (2,027 words) [view diff] exact match in snippet view article find links to article

J, Ackler S, Refici M, Ferguson D, et al. (June 2008). "Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft

BAG5 (581 words) [view diff] case mismatch in snippet view article find links to article

with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors

IKZF3 (1,215 words) [view diff] exact match in snippet view article find links to article

"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30

Athanogene (104 words) [view diff] exact match in snippet view article find links to article

for "against death" ('athánatos), was incorporated into name of the gene Bcl-2-associated athanogene 1 (BAG-1; alias HAP46/BAG-1M) upon discovery of its

Robert Scott Mylne (270 words) [view diff] no match in snippet view article find links to article

Rev Robert Scott Mylne FRSE FSSA FSA BCL (2 April 1854 – 23 November 1920) was an English vicar, antiquarian and historical author. He was born on 2 April

Craig B. Thompson (2,348 words) [view diff] exact match in snippet view article find links to article

development and immune system homeostasis. His group discovered the first Bcl-2 homolog to be identified, Bcl-Xl, and described the first BH3-only containing

Sanford Burnham Prebys (2,481 words) [view diff] exact match in snippet view article find links to article

previously unknown pro- and anti-apoptotic proteins, namely caspases, IAPs, and Bcl-2 family members. The demonstration by Institute scientists that cells deprived

Mast cell leukemia (1,166 words) [view diff] exact match in snippet view article find links to article

CD2 and CD25. Malignant mast cells overexpress the anti-apoptosis gene, bcl-2. A mutation called KIT mutation is detected in most patients. Total serum

Locked nucleic acid (1,647 words) [view diff] exact match in snippet view article find links to article

molecule, termed SPC2996, has been developed to target the mRNA coding for Bcl-2 oncoprotein, a protein that inhibits apoptosis in chronic lymphocytic leukemia

Betulinic acid (1,916 words) [view diff] exact match in snippet view article find links to article

"23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells". Life Sciences. 72 (1):

David Kirsch (459 words) [view diff] exact match in snippet view article find links to article

biology and radiation oncology. His highest cited papers are "Conversion of Bcl-2 to a Bax-like death effector by caspases", at 1332 times, and "Restoration

Phycocyanin (3,808 words) [view diff] case mismatch in snippet view article find links to article

decrease BCl-2 (regulator of apoptosis) production. Here, BCl-2 inhibits proteins called caspases. Caspases are part of the apoptosis pathway. When BCl-2 decreases

H. Robert Horvitz (2,156 words) [view diff] exact match in snippet view article find links to article

gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2". Cell. 76 (4): 665–76. doi:10.1016/0092-8674(94)90506-1. PMID 7907274.

T. S. Wiley (926 words) [view diff] exact match in snippet view article find links to article

cells: inverse effects on Bcl-2 and p53". Ann Clin Lab Sci. 28 (6): 360–9. PMID 9846203. Formby, Bent; T.S. Wiley (1999). "Bcl-2, survivin and variant CD44

ARHGAP1 (1,288 words) [view diff] exact match in snippet view article find links to article

Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents

Catherine Day (biochemist) (754 words) [view diff] exact match in snippet view article

Jerry M. Adams, and David CS Huang. "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Forskolin (839 words) [view diff] exact match in snippet view article find links to article

cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential

Ischemic cell death (866 words) [view diff] exact match in snippet view article find links to article

levels, initiating the oncotic pathway. The anti-apoptotic gene product Bcl-2 is not an active inhibitor of UCP-2 initiated cell death, further distinguishing

Gerard Evan (883 words) [view diff] exact match in snippet view article find links to article

R. J.; Evan, G. I.; Guild, B. C. (1995). "Induction of apoptosis by the Bcl-2 homologue Bak". Nature. 374 (6524): 733–736. Bibcode:1995Natur.374..733C

Follicular dendritic cell sarcoma (2,551 words) [view diff] exact match in snippet view article find links to article

microtubules. Taxotere has an added benefit though; it also phosphorylates bcl-2 to halt the anti-apoptotic pathway. The dual effect of taxotere on integral

DAD1 (695 words) [view diff] exact match in snippet view article find links to article

mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family". J. Biochem. 128 (3): 399–405. doi:10.1093/oxfordjournals

YWHAQ (1,999 words) [view diff] exact match in snippet view article find links to article

Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function"

Mitochondrial ribosomal protein L41 (587 words) [view diff] exact match in snippet view article find links to article

PMID 15489334. Chintharlapalli SR, Jasti M, Malladi S, et al. (2005). "BMRP is a Bcl-2 binding protein that induces apoptosis". J. Cell. Biochem. 94 (3): 611–26

Adenovirus E1B protein (952 words) [view diff] case mismatch in snippet view article find links to article

PMC 289151. PMID 14633975. White, E; Cuconati, A (2002). "Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection". Genes & Development

TUBA8 (868 words) [view diff] exact match in snippet view article find links to article

microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103

Interleukin-15 receptor (690 words) [view diff] exact match in snippet view article find links to article

(PI3-kinase) and Akt, leading to the induction of the anti-apoptotic protein Bcl-2. Additionally, they stimulate the Ras/Raf/MEK/mitogen-activated protein

ZNF384 (636 words) [view diff] exact match in snippet view article find links to article

S2CID 8838301. Graflund M, Sorbe B, Karlsson M (May 2002). "MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early

Richard Youle (614 words) [view diff] exact match in snippet view article find links to article

Bcl-2 and mitochondria. Youle found that an important step in the initiation of cell death is the migration of Bcl-xL and Bax, two members of the Bcl-2

TUBA1C (804 words) [view diff] exact match in snippet view article find links to article

microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–6810. doi:10.1093/emboj/cdf683. PMC 139103

Suresh Kumar Rayala (499 words) [view diff] exact match in snippet view article find links to article

functional groups in predicting the activity of small molecule inhibitors for Bcl-2 and Bcl-xL". Chemical Biology & Drug Design. 90 (2): 308–316. doi:10.1111/cbdd

CDC42 (3,700 words) [view diff] exact match in snippet view article find links to article

Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents

Reactive oxygen species (8,460 words) [view diff] exact match in snippet view article find links to article

pore-stabilizing proteins (Bcl-2 and Bcl-xL) as well as inhibiting pore-destabilizing proteins (Bcl-2-associated X protein, Bcl-2 homologous antagonist/killer)

Mitochondrial outer membrane permeabilization (307 words) [view diff] exact match in snippet view article find links to article

outer mitochondrial membranes into the cytosol. Initiation of MOMP involves Bcl-2 family proteins, including BAX and BAK. The outer mitochondrial membrane

5,10-Methylenetetrahydrofolate (324 words) [view diff] exact match in snippet view article find links to article

5-MTHF: 5-methyltetrahydrofolate; 5,10-methylenetetrahydrofolate; BAX: Bcl-2-associated X protein; BHMT: betaine-homocysteine S-methyltransferase; CBS:

HNRPD (1,472 words) [view diff] exact match in snippet view article find links to article

Schiavone N, Capaccioli S (May 2002). "AUF1 Is a bcl-2 A + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis" (PDF).

LATS2 (746 words) [view diff] exact match in snippet view article find links to article

"Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res. 298 (2): 329–38. doi:10.1016/j.yexcr.2004

Calcineurin (1,930 words) [view diff] exact match in snippet view article find links to article

through transcription factor NF-AT by interactions between calcineurin and Bcl-2". Nature. 386 (6626): 728–31. Bibcode:1997Natur.386..728S. doi:10.1038/386728a0

RTN1 (1,052 words) [view diff] exact match in snippet view article find links to article

(November 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity". Oncogene

Serum albumin (793 words) [view diff] exact match in snippet view article find links to article

albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2 2bx8: HUMAN SERUM ALBUMIN COMPLEXED WITH AZAPROPAZONE 2bxa: HUMAN SERUM

40S ribosomal protein S3a (1,051 words) [view diff] exact match in snippet view article find links to article

Taniguchi T (2002). "Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a". Biochemistry. 41 (3): 929–34

MAPK11 (1,233 words) [view diff] exact match in snippet view article find links to article

apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release" (PDF). J. Biol. Chem. 276 (42):

BNIP3L (880 words) [view diff] exact match in snippet view article find links to article

Okuyama A, Tsujimoto Y (1999). "Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering

Lisaftoclax (190 words) [view diff] case mismatch in snippet view article find links to article

lymphocytic lymphoma (SLL). It is a selective inhibitor of the B-cell lymphoma 2 (BCL-2) protein, designed to restore the normal process of programmed cell death

S100 protein (1,164 words) [view diff] exact match in snippet view article find links to article

Nicosia SV, Kounelis S, Jones M (1998). "Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive Langerhans cells in endometrial carcinoma"

Julia Wolfe (3,307 words) [view diff] no match in snippet view article find links to article

amp vc, amp db) Window of Vulnerability (1991) – 9 minutes – 3(2pic).3.3(bcl).2+cbn/4.3.3(btbn).1/timp.4perc/hp.syn.pf/str The Vermeer Room (1989) – 11

PAWR (1,352 words) [view diff] exact match in snippet view article find links to article

Lopez-Berestein G (May 2003). "Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter". The Journal of Biological Chemistry. 278

Chlorambucil (1,174 words) [view diff] exact match in snippet view article find links to article

apoptosis via the accumulation of cytosolic p53 and subsequent activation of Bcl-2-associated X protein, an apoptosis promoter. Chlorambucil alkylates and

Sigma receptor (1,832 words) [view diff] exact match in snippet view article find links to article

"Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2". Anesthesia and Analgesia. 104 (5): 1179–84, tables of contents. doi:10

Nef (protein) (1,133 words) [view diff] exact match in snippet view article

known to phosphorylate and inactivate Bad, a proapoptotic member of the Bcl-2 family thus protecting the infected cells from apoptosis.[citation needed]

Douglas R. Green (954 words) [view diff] exact match in snippet view article find links to article

in T lymphocytes, the role of c-Myc in this process and the finding that Bcl-2 cooperates with Myc in oncogenesis by blocking apoptosis. More recently

SERPINB8 (518 words) [view diff] exact match in snippet view article find links to article

PMC 139241. PMID 12477932. Hoetelmans RW (2004). "Nuclear partners of Bcl-2: Bax and PML". DNA Cell Biol. 23 (6): 351–4. doi:10.1089/104454904323145236

Chromosome 14 (1,832 words) [view diff] exact match in snippet view article find links to article

(Machado-Joseph disease) BCL2L2: encoding the anti-apoptotic protein Bcl-w of the Bcl-2 family C14orf80: encoding protein C14orf80 C14orf93: encoding protein C14orf93

DYNLL1 (1,545 words) [view diff] exact match in snippet view article find links to article

O'Reilly LA, King SM, Strasser A (Mar 1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex"

MELK (977 words) [view diff] exact match in snippet view article find links to article

carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family". Breast Cancer Research. 9 (1): R17. doi:10.1186/bcr1650. PMC 1851384

Mir-143 (1,573 words) [view diff] exact match in snippet view article find links to article

osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2". Oncol Rep. 24 (5): 1363–9. doi:10.3892/or_00000994. PMID 20878132. Liu

BAG3 (3,610 words) [view diff] exact match in snippet view article find links to article

Inazawa J, Kamada S, Tsujimoto Y (Nov 1999). "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death". Oncogene. 18 (46): 6183–90

John Angus Hickman (947 words) [view diff] case mismatch in snippet view article find links to article

focussing on the discovery of drugs inhibiting the anti-apoptotic proteins BCL-2 and MCL-13,14. Retiring in 2010 he then coordinated a European Union Innovative

HOXC6 (1,241 words) [view diff] exact match in snippet view article find links to article

deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression". The Journal of Biological Chemistry. 287 (42): 35678–35688

Angiogenin (1,943 words) [view diff] exact match in snippet view article find links to article

"Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner". Journal of Cellular Physiology. 227 (4): 1639–1644. doi:10

Tyrosine-protein kinase BLK (847 words) [view diff] exact match in snippet view article find links to article

et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6

CISD2 (640 words) [view diff] case mismatch in snippet view article find links to article

Shore GC (February 2010). "Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1". EMBO J. 29 (3): 606–18. doi:10

SMN1 (1,274 words) [view diff] exact match in snippet view article find links to article

Tsujimoto Y (November 1997). "Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy". Nature. 390 (6658): 413–7

GATA6 (1,407 words) [view diff] exact match in snippet view article find links to article

factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis". J. Clin. Endocrinol. Metab. 88 (4): 1858–65

CYC1 (1,767 words) [view diff] exact match in snippet view article find links to article

adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2". The Journal of Experimental Medicine. 193 (4): 509–19. doi:10.1084/jem

CYC1 (1,767 words) [view diff] exact match in snippet view article find links to article

adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2". The Journal of Experimental Medicine. 193 (4): 509–19. doi:10.1084/jem

IL2RB (1,698 words) [view diff] exact match in snippet view article find links to article

Taniguchi T (1995). "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation". Cell. 81

Arenobufagin (1,536 words) [view diff] exact match in snippet view article find links to article

potential was detected (in a dose-dependent manner), as well as a high Bax/Bcl-2 ratio, which is associated with apoptosis, or programmed cell death. Bax

BMF (248 words) [view diff] exact match in snippet view article find links to article

Central African Republic BMF (gene), a gene that encodes the human protein Bcl-2-modifying factor BMF (record label), a record label based in Ireland Be

ITM2B (717 words) [view diff] exact match in snippet view article find links to article

a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2". Oncogene. 21 (20): 3181–9. doi:10.1038/sj.onc.1205464. PMID 12082633.

CD69 (2,275 words) [view diff] exact match in snippet view article find links to article

PMID 12210415. S2CID 21271659. Foerster M, Haefner D, Kroegel C (October 2002). "Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification

Homocysteine (2,079 words) [view diff] exact match in snippet view article find links to article

hyperhomocysteinemia - 5-MTHF: 5-methyltetrahydrofolate; 5,10-methyltetrahydrofolate; BAX: Bcl-2-associated X protein; BHMT: betaine-homocysteine S-methyltransferase; CBS:

List of histologic stains that aid in diagnosis of cutaneous conditions (254 words) [view diff] exact match in snippet view article find links to article

Mucopolysaccharidoses Alizarin red Calcinosis cutis Azure A Mast cell Mastocytosis Bcl-2 Basal cell carcinoma Primary cutaneous marginal zone lymphoma Diffuse large

Bim (disambiguation) (361 words) [view diff] exact match in snippet view article

Fisheries Board British Institute of Management, London BCL2L11, protein from Bcl-2 protein family produced by bim gene BiM, abbreviation for bimetal BiM, Binary

Boron triazide (716 words) [view diff] no match in snippet view article find links to article

Intermediates Generated via Photolysis of B(N 3 ) 3 , BCl(N 3 ) 2 , and BCl 2 (N 3 ) in Low-Temperature Argon Matrices †". The Journal of Physical Chemistry

Diazoxide (927 words) [view diff] exact match in snippet view article find links to article

prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase". Endocrinology.

GLI2 (1,852 words) [view diff] case mismatch in snippet view article find links to article

Xhox3 genes involved in positional information. The anti-apoptotic protein BCL-2 is up regulated by Gli2 and, to a lesser extent, Gli1 – but not Gli3, which

Homeobox protein CDX-2 (2,211 words) [view diff] exact match in snippet view article find links to article

JL (September 2002). "The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells". Biochemical and Biophysical Research

Genome instability (4,560 words) [view diff] exact match in snippet view article find links to article

translocation of the immunoglobulin promoter to the Bcl-2 gene, giving rise to high levels of Bcl-2 protein, which inhibits apoptosis. DNA-damaged B-cells

Bone resorption (2,251 words) [view diff] exact match in snippet view article find links to article

Majeska RJ, Schaffler MB (May 2002). "Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling

Internal ribosome entry site (1,775 words) [view diff] exact match in snippet view article find links to article

Inhibitors of apoptosis X-linked inhibitor of apoptosis (XIAP), HIAP2, Bcl-xL, Bcl-2 Proteins localized in neuronal dendrites Activity-regulated cytoskeletal

Levomefolic acid (1,214 words) [view diff] exact match in snippet view article find links to article

hyperhomocysteinemia. 5-MTHF: 5-methyltetrahydrofolate; 5,10-methyltetrahydrofolate; BAX: Bcl-2-associated X protein; BHMT: betaine-homocysteine S-methyltransferase; CBS:

MYB (gene) (1,863 words) [view diff] exact match in snippet view article

associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression". Cancer Res. 58 (22): 5168–75. PMID 9823328. Verbeek W, Gombart

BH3 (96 words) [view diff] exact match in snippet view article find links to article

refer to The molecule borane, which has a chemical formula of BH3. The Bcl-2 homology domain 3. BH3, the Chinese abbreviation for Honkai Impact 3rd (Chinese:

RHEB (2,661 words) [view diff] exact match in snippet view article find links to article

activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The EMBO Journal. 16 (7): 1686–94. doi:10.1093/emboj/16.7

Interleukin-7 receptor-α (840 words) [view diff] exact match in snippet view article find links to article

1317–25. PMID 8709637. Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient

IFN1@ (529 words) [view diff] case mismatch in snippet view article find links to article

S2CID 31073749. Karauzum SB, Yasar D, Dirice E, et al. (2007). "Lack of BCL-2 confers interferon-alpha sensitivity to B-cell lymphomas". Growth Factors

Genetics of aging (2,844 words) [view diff] exact match in snippet view article find links to article

"Achilles heel" of senescent cells using RNA interference approaches, including Bcl-2-, AKT-, p21-, and tyrosine kinase-related pathways. They then used drugs

DU145 (733 words) [view diff] case mismatch in snippet view article find links to article

genes, including cyclin A, cyclin D1, and antiapoptotic proteins, such as BCL-2, and BCL-xL. After treatment of DU-145 with EXT, the aforementioned genes

VDAC3 (2,560 words) [view diff] exact match in snippet view article find links to article

been observed to interact with pro- or antiapoptotic proteins, such as Bcl-2 family proteins and kinases, and so may contribute to apoptosis independently

Lymphoid hyperplasia (539 words) [view diff] exact match in snippet view article find links to article

Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles)

VDAC2 (2,675 words) [view diff] exact match in snippet view article find links to article

been observed to interact with pro- or antiapoptotic proteins, such as Bcl-2 family proteins and kinases, and so may contribute to apoptosis independently

SIVA1 (1,004 words) [view diff] case mismatch in snippet view article find links to article

cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2". Cancer Res. 65 (12): 5301–9. doi:10.1158/0008-5472.CAN-04-3270. PMID 15958577

Douglas Scherr (2,302 words) [view diff] case mismatch in snippet view article find links to article

Investigation, Ferdinand C. Valentine Urology Residents Essay Meeting, “BCL-2 and P53 expression in clinically localized prostate cancer as predictive

Luk Van Parijs (1,602 words) [view diff] exact match in snippet view article find links to article

Parijs L, Peterson DA, and Abbas AK (1998) The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens. Immunity 8(2):

Mitraphylline (449 words) [view diff] exact match in snippet view article find links to article

Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells". British Journal of Haematology

Paraptosis (2,767 words) [view diff] exact match in snippet view article find links to article

p53, BAF), x-chromosome-linked inhibitor (xiap), and Bcl-xL( from the Bcl-2 family) did not prevent cell death in 293T cells when induced by IGFIR-IC

Persistent polyclonal B-cell lymphocytosis (371 words) [view diff] exact match in snippet view article find links to article

or without premature chromosome condensation. Also, a t(14;18)(q22;21) bcl-2/IgH rearrangement has been described, as usually seen in follicular lymphoma

Clusterin (2,433 words) [view diff] exact match in snippet view article find links to article

activation, which then skews the proapoptotic:antiapoptotic ratio of present Bcl-2 family members, resulting in mitochondrial dysfunction and cell death. p53

Diallyl disulfide (2,797 words) [view diff] exact match in snippet view article find links to article

PMID 16475702. Huang, Z; Lei, X; Zhong, M; Zhu, B; Tang, S; Liao, D (2007). "Bcl-2 small interfering RNA sensitizes cisplatin-resistant human lung adenocarcinoma

APOL6 (494 words) [view diff] exact match in snippet view article find links to article

Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer

Repinotan (2,572 words) [view diff] exact match in snippet view article find links to article

explain repinotan's neuroprotective properties. In addition, the protein Bcl-2, the serotonergic glial growth factor S-100beta, and Nerve Growth Factor

Neuroprotection (4,030 words) [view diff] exact match in snippet view article find links to article

molecules, upregulates neuroprotective factors (e.g., B-cell lymphoma-2 (Bcl-2), heat shock protein 70 (HSP-70)), and concomitantly downregulates pro-apoptotic

CD19 (3,916 words) [view diff] exact match in snippet view article find links to article

Desmoulière A, Durand I, de Bouteiller O, Garrone P, et al. (January 1996). "Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts"

TNFRSF18 (2,117 words) [view diff] exact match in snippet view article find links to article

pro-apoptotic markers (e.g. Bax) and decreased anti-apoptotic markers (e.g. Bcl-2). Asthma model: GITR activation drives an infiltration of eosinophils to

YWHAE (1,633 words) [view diff] exact match in snippet view article find links to article

Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3

Forkhead box protein O1 (3,343 words) [view diff] exact match in snippet view article find links to article

Additionally, FOXO1 trans-activate Bim protein, which a member of the Bcl-2 family that promotes apoptosis and plays a role in the intrinsic mitochondrial

Protein dynamics (2,603 words) [view diff] case mismatch in snippet view article find links to article

mutations.[citation needed] Research on promiscuous proteins within the BCL-2 family revealed that nanosecond-scale protein dynamics can play a crucial

Cecropin (1,552 words) [view diff] exact match in snippet view article find links to article

cationic cecropins, and analysis suggests that this motif may interact with Bcl-2, a protein implicated in apoptosis. Further study of cecropin structure

Retinoid X receptor alpha (2,892 words) [view diff] exact match in snippet view article find links to article

Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK (2004). "Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3"

APAF1 (1,643 words) [view diff] exact match in snippet view article find links to article

Merino J, Garcia I, Koseki T, Hu Y, Chen S, Núñez G (Dec 1998). "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell

HDAC9 (2,396 words) [view diff] exact match in snippet view article find links to article

microRNA-92a to repress the progression of intracranial aneurysm via silencing Bcl-2-like protein 11". Journal of Drug Targeting. 29 (7): 761–770. doi:10.1080/1061186X

Methylsulfonylmethane (2,762 words) [view diff] exact match in snippet view article find links to article

LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins". Immunopharmacology and Immunotoxicology

Cadherin-2 (3,399 words) [view diff] exact match in snippet view article find links to article

Agrogiannis G, Patsouris E (September 2010). "Apoptosis-related factors p53, bcl-2 and the defects of force transmission in dilated cardiomyopathy". Pathology

Drosera (5,670 words) [view diff] exact match in snippet view article find links to article

arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio". Cell Death Discovery. 2: 15062. doi:10.1038/cddiscovery.2015.62

TGF beta 1 (2,290 words) [view diff] exact match in snippet view article find links to article

(2002). "Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21". Leuk. Lymphoma

METAP2 (3,034 words) [view diff] exact match in snippet view article find links to article

"Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity". Am. J. Pathol. 159 (2): 721–31. doi:10

Goniothalamus cheliensis (276 words) [view diff] exact match in snippet view article find links to article

of leukemia cell apoptosis by cheliensisin A involves downregulation of Bcl-2 expression". Acta Pharmacologica Sinica. 26 (5): 623–628. doi:10.1111/j

K562 cells (1,386 words) [view diff] exact match in snippet view article find links to article

cellular components involved in the cycle of apoptosis such as BCR/ABL, Bcl-2, Bax protein, and cytochrome C. The tumor suppressor gene p53 is also important

S100A10 (4,728 words) [view diff] exact match in snippet view article find links to article

SY, Kaipia A, Zhu L, Hsueh AJ (Nov 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3

Glucose-elevating agent (189 words) [view diff] exact match in snippet view article find links to article

Prevents Diabetes through Inhibiting Pancreatic β-Cells from Apoptosis via Bcl-2/Bax Rate and p38-β Mitogen-Activated Protein Kinase". Endocrinology. 148

Gene knockout (2,559 words) [view diff] exact match in snippet view article find links to article

(shRNA). This effectively stops the gene from being expressed. Oncogenes like Bcl-2 and p53, as well as genes linked to neurological disease, genetic disorders

Mir-1 microRNA precursor family (3,291 words) [view diff] exact match in snippet view article find links to article

(May 2009). "MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2". International Heart Journal. 50 (3): 377–87. doi:10.1536/ihj.50.377. PMID 19506341

Langerhans cell histiocytosis (4,022 words) [view diff] exact match in snippet view article find links to article

SV; Kounelis, S; Jones, M (May 1998). "Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive Langerhans cells in endometrial carcinoma"

Salubrinal (314 words) [view diff] exact match in snippet view article find links to article

M807325200. PMC 2613630. PMID 19017641. Kessel D (August 2006). "Protection of Bcl-2 by salubrinal". Biochemical and Biophysical Research Communications. 346

Disulfiram (3,166 words) [view diff] exact match in snippet view article find links to article

Manucci JL, et al. (June 2011). "Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation"

C6orf222 (1,399 words) [view diff] exact match in snippet view article find links to article

predicted BH3 domain in the C6orf222 protein was found to interact with both Bcl-2 and Bcl-xL, implicating C6orf222 as being involved in apoptosis. Table of

Memory T cell (3,781 words) [view diff] exact match in snippet view article find links to article

on-off-on expression pattern, including interleukin-7 receptor alpha (IL-7Rα), Bcl-2, CD26L, and others. The other model is the developmental differentiation

C6orf222 (1,399 words) [view diff] exact match in snippet view article find links to article

predicted BH3 domain in the C6orf222 protein was found to interact with both Bcl-2 and Bcl-xL, implicating C6orf222 as being involved in apoptosis. Table of

Glaucarubin (353 words) [view diff] case mismatch in snippet view article find links to article

Herlyn, Meenhard; You, Jianxin (2020). "Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity". Biology. 9 (2):

Human serum albumin (4,056 words) [view diff] exact match in snippet view article find links to article

albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2 2bx8: HUMAN SERUM ALBUMIN COMPLEXED WITH AZAPROPAZONE 2bxa: HUMAN SERUM

T-2 mycotoxin (3,186 words) [view diff] exact match in snippet view article find links to article

there has been noticed that the level of the pro-apoptotic factor Bas (Bcl-2-associated X protein) was increased and the level of Bcl-xl, an anti-apoptotic

University of Konstanz (4,404 words) [view diff] exact match in snippet view article find links to article

Mental and Physical Health (Risk Dynamics – FOR 2374) New Insights into the Bcl-2 family interactions – from biophysics to function (FOR 2036) Nonlinear response

Transporter Classification Database (5,159 words) [view diff] exact match in snippet view article find links to article

channel family 1.A.20 BCL2/Adenovirus E1B-interacting protein 3 family 1.A.21 Bcl-2 family 1.A.22 Large-conductance mechanosensitive ion channel 1.A.23 Small-conductance

Sjögren's disease (9,327 words) [view diff] exact match in snippet view article find links to article

Loro LL, Johannessen AC, Jonsson R (December 2002). "CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic

GroES (4,108 words) [view diff] exact match in snippet view article find links to article

Samsamshariat A, Mestril R, Wang PH (2003). "Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac

Cyclin-dependent kinase 5 (5,162 words) [view diff] case mismatch in snippet view article find links to article

activated by cyclin I, this regulator causes an increase in the expression of BCl-2 family proteins, which are associated with anti-apoptotic functions. The

Subventricular zone (3,371 words) [view diff] exact match in snippet view article find links to article

subventricular zone of the adult human brain: evidence for the involvement of Bcl-2". Neuroscience Research. 37 (1): 67–78. doi:10.1016/S0168-0102(00)00102-4

David S. Bredt (1,807 words) [view diff] exact match in snippet view article find links to article

paradigm, they also found an array of other neuronal proteins including Bcl-2 (Nature Communications, 2019), spermidine/spermine N1-acetyltransferase

Wistar Institute (2,825 words) [view diff] exact match in snippet view article find links to article

Y; Cossman, J; Jaffe, E; Croce, CM (June 21, 1985). "Involvement of the bcl-2 gene in human follicular lymphoma". Science. 228 (4706): 1440–1443. Bibcode:1985Sci

IGFBP3 (4,717 words) [view diff] exact match in snippet view article find links to article

"Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast

HSPA1A (3,267 words) [view diff] exact match in snippet view article find links to article

Maser RS, Scully WJ, Delach SM, Johnson DE (September 2001). "Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death

Mitochondrion (18,022 words) [view diff] exact match in snippet view article find links to article

anti-apoptotic factors support this model; for example, the anti-apoptotic factor Bcl-2 has been shown to interact with IP3Rs to reduce Ca2+ filling of the ER,

TUBB1 (738 words) [view diff] exact match in snippet view article find links to article

microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103

Aggresome (1,654 words) [view diff] exact match in snippet view article find links to article

ubiquitin-independent pathway mediated by the stress-induced co-chaperone BAG3 (Bcl-2-associated athanogene 3), which transfers misfolded protein substrates bound

ST8SIA1 (1,036 words) [view diff] exact match in snippet view article find links to article

apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2". FEBS Lett. 568 (1–3): 183–7. doi:10.1016/j.febslet.2004.05.020. PMID 15196944

Translin (1,211 words) [view diff] exact match in snippet view article find links to article

to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family". Oncogene. 9 (4): 1109–15. PMID 8134113

PARL (1,095 words) [view diff] exact match in snippet view article find links to article

interactions with the mitochondrial GTPase optic atrophy 1 (OPA1) and the Bcl-2 family-related protein HAX1. OPA1 mainly regulates mitochondrial fusion

Neuroplasticity (13,302 words) [view diff] exact match in snippet view article find links to article

the role of inflammation and inflammatory cytokines, proteins such as Bcl-2 proteins and neutrophorins, and energy production via mitochondria. JT Wall

Cyclin-dependent kinase 2 (4,161 words) [view diff] exact match in snippet view article find links to article

Kim MH, Chang IY, Lee JS, Chung MH, Hahm KS, You HJ (February 2005). "Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F

Olfactory tubercle (3,948 words) [view diff] exact match in snippet view article find links to article

to the olfactory tubercle and involvement of the antiapoptotic protein bcl-2". European Journal of Neuroscience. 16 (10): 1917–1924. doi:10.1046/j.1460-9568

KLF4 (6,848 words) [view diff] exact match in snippet view article find links to article

hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia cells involving the bcl-2/bax pathway". Cell Stress & Chaperones. 15 (6): 905–12. doi:10.1007/s12192-010-0199-5

SNCAIP (1,175 words) [view diff] exact match in snippet view article find links to article

(Dec 2001). "Lack of binding observed between human alpha-synuclein and Bcl-2 protein family". Neurosci. Lett. 316 (2): 103–7. doi:10.1016/s0304-3940(01)02330-8

TARBP2 (1,413 words) [view diff] exact match in snippet view article find links to article

a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins". Molecular and Cellular Biology. 19 (6): 4390–404. doi:10

BNC1 (854 words) [view diff] exact match in snippet view article find links to article

Willis SN, Wei A, et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function"

Palmatine (2,171 words) [view diff] exact match in snippet view article find links to article

time-dependent manner via damaging severely to DNA and inhibiting the activity of Bcl-2 protein. In addition, palmatine can inhibit the proliferation and infiltration

Tubulin beta-4B chain (915 words) [view diff] exact match in snippet view article find links to article

microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103

Mitochondrial fusion (2,358 words) [view diff] exact match in snippet view article find links to article

addition, Mfn2 specifically has been shown to associate with Bax and Bak (Bcl-2 family, TC#1.A.21), resulting in altered Mfn2 activity, indicating that

SH3GLB1 (1,263 words) [view diff] exact match in snippet view article find links to article

other BAR proteins, endophilin-B1 interacts with the pro-apoptotic factor Bcl-2-associated X protein (Bax) and SH3GLB2. It has also been shown to interact

Palmatine (2,171 words) [view diff] exact match in snippet view article find links to article

time-dependent manner via damaging severely to DNA and inhibiting the activity of Bcl-2 protein. In addition, palmatine can inhibit the proliferation and infiltration

Molecular dynamics (10,208 words) [view diff] exact match in snippet view article find links to article

the proapoptotic proteins Bak, Bax, Bid and Hrk bound to the Bcl-xL and Bcl-2 proteins". Journal of Computer-aided Molecular Design. 18 (1): 13–22. Bibcode:2004JCAMD

ADP/ATP translocase 1 (1,138 words) [view diff] exact match in snippet view article find links to article

is encoded by the SLC25A4 gene. SLC25A4 has been shown to interact with Bcl-2-associated X protein. GRCh38: Ensembl release 89: ENSG00000151729 – Ensembl

Tubulin beta-4B chain (915 words) [view diff] exact match in snippet view article find links to article

microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103

VRK2 (526 words) [view diff] exact match in snippet view article find links to article

VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival". J. Gen. Virol. 87 (Pt 10): 2869–78. doi:10

Chaperone-assisted selective autophagy (1,144 words) [view diff] exact match in snippet view article find links to article

family has 6 cochaperone members and BAG1 was identified as an interactor of Bcl-2 proteins which is an anti-apoptotic protein. The activation of HSF1 is the

Leonurine (1,482 words) [view diff] exact match in snippet view article find links to article

"Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria

CAPZB (1,525 words) [view diff] exact match in snippet view article find links to article

demonstrated that the protein turnover of CapZβ1 is in part regulated by the Bcl-2–associated athanogene, BAG3, through a mechanism involving the association

Maria Kavallaris (1,288 words) [view diff] exact match in snippet view article find links to article

Murphy, V Ranganathan, ML Farnsworth, M Kavallaris and Richard B Lock. Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced

Adenovirus genome (761 words) [view diff] exact match in snippet view article find links to article

E1B 19K suppresses apoptosis by mimicking the action of cellular protein Bcl-2. Control protein E1B 55K binds to and inactivates the transcriptional regulator

Galectin-4 (1,512 words) [view diff] exact match in snippet view article find links to article

IL-6 was also confirmed to enhance the expression of B-cell lymphoma-2(Bcl-2) and B-cell lymphoma-extra large (Bcl-xl) through activating the STAT3(Signal

Index of oncology articles (5,119 words) [view diff] exact match in snippet view article find links to article

59-8862 – BB-10901 – BBBD – BBR 2778 – BBR 3464 – BCG – BCG solution – bcl-2 antisense oligodeoxynucleotide G3139 – BCX-1777 – Beckwith-Wiedemann syndrome

Epigenetic therapy (5,831 words) [view diff] case mismatch in snippet view article find links to article

DNA methylation in relation to autism are oxytocin receptor, SHANK3, and BCL-2. Oxytocin is a hormone that partially controls social interactions, this

Elliott D. Kieff (944 words) [view diff] exact match in snippet view article find links to article

Croom-Carter D, Wang F, Longnecker R, Kieff E, Rickinson A. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected

Neurobiological effects of physical exercise (9,595 words) [view diff] exact match in snippet view article find links to article

hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation". The Journal of Physiological

Gapmer (1,142 words) [view diff] exact match in snippet view article find links to article

"Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer". Pharmaceutical Research. 34 (2): 310–320

Listener fatigue (1,860 words) [view diff] exact match in snippet view article find links to article

Yamashita D., Minami S. B., Kanzaki S., Ogawa K., Miller J. M. (2008). "Bcl-2 genes regulate noise-induced hearing loss. [Article]". Journal of Neuroscience

Laurent Susini (1,559 words) [view diff] exact match in snippet view article find links to article

Laurent Susini described TCTP as a pro-survival protein antagonizing BAX, Bcl-2-associated X protein, function Chumakov, I.M., Rigault, P., Le Gall, I.

Tubulin beta-4A chain (1,293 words) [view diff] exact match in snippet view article find links to article

microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO Journal. 21 (24): 6801–6810. doi:10.1093/emboj/cdf683

YWHAZ (3,620 words) [view diff] exact match in snippet view article find links to article

BAX in the cytoplasm, effectively preventing activation of proapoptotic Bcl-2 and Bcl-XL, as well as by preventing NOXA from inhibiting antiapoptotic

Pirtobrutinib (1,165 words) [view diff] case mismatch in snippet view article find links to article

including a Bruton's tyrosine kinase (BTK) inhibitor and a B-cell lymphoma-2 (BCL-2) inhibitor. Participants received a median of five prior lines of therapy

MicroRNA 148a (694 words) [view diff] exact match in snippet view article find links to article

Hu H, Sheng H, Lai M (2011). "MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer". Cell Death Differ. 18 (11): 1702–10. doi:10.1038/cdd

Dena Dubal (1,109 words) [view diff] exact match in snippet view article find links to article

Merchenthaler, Istvan; Wise, Phyllis M. (1999-08-01). "Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors". The Journal

Hypothermia therapy for neonatal encephalopathy (5,965 words) [view diff] case mismatch in snippet view article find links to article

and there may be an increase in expression of the anti-apoptotic protein BCl-2. Many physicians over the centuries have tried to resuscitate babies after

FIS1 (1,714 words) [view diff] exact match in snippet view article find links to article

Kuo TH (Apr 2005). "Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1". Molecular and Cellular Biochemistry.

YWHAH (3,102 words) [view diff] exact match in snippet view article find links to article

Kaipia A, Zhu L, Hsueh AJ (November 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3

Chandrima Shaha (1,059 words) [view diff] exact match in snippet view article find links to article

earliest eukaryotes. Host-parasite interaction studies show the involvement of Bcl-2 proteins in parasite survival. Other studies with cells having high division

Seamus Martin (biochemist) (1,192 words) [view diff] exact match in snippet view article

Cell, 49, 1034–1048. Hollville, E., Carroll, R., and Martin SJ. (2014) Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating

Galectin-9 (2,173 words) [view diff] exact match in snippet view article find links to article

ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins". The Journal of Biological Chemistry. 282 (39): 28960–70. doi:10

Lipoarabinomannan (2,672 words) [view diff] exact match in snippet view article find links to article

Activation of a PI3K pathway is sufficient to trigger phosphorylation of the Bcl-2 family member Bad by ManLAM. ManLAM is able to activate the serine/threonine

AP5M1 (1,419 words) [view diff] exact match in snippet view article find links to article

that MuD regulates the expression of BAX, a pro-apoptotic member of the Bcl-2 family of proteins. Due to— and dependent upon— this relationship, MuD has

Primary pigmented nodular adrenocortical disease (1,578 words) [view diff] exact match in snippet view article find links to article

Ekert, P; Strasser, A; Puthalakath, H (2014). "Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice". Cell Death and Differentiation

RNA silencing (5,498 words) [view diff] case mismatch in snippet view article find links to article

Cancer CALAA-01 Solid tumor RRM2 Cancer SPC2996 chronic lymphocytic leukemia BCL-2 Cancer ALN-VSP02 Solid tumor VEGF, kinesin spindle protein Cancer NCT00672542

Primary pigmented nodular adrenocortical disease (1,578 words) [view diff] exact match in snippet view article find links to article

Ekert, P; Strasser, A; Puthalakath, H (2014). "Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice". Cell Death and Differentiation

A. Thomas Look (1,392 words) [view diff] exact match in snippet view article find links to article

suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3". Cell. 133 (5): 864–877. doi:10.1016/j.cell.2008.03.037

Stapled peptide (1,723 words) [view diff] case mismatch in snippet view article find links to article

these peptides were taken up by cancer cells and bound their physiologic BCL-2 family targets, which correlated with the induction of cell death. It was

Druggability (1,988 words) [view diff] case mismatch in snippet view article find links to article

drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members". Clinical Cancer Research. 13 (24): 7264–7270. doi:10.1158/1078-0432

Ivo Meinhold-Heerlein (1,193 words) [view diff] exact match in snippet view article find links to article

Kallioniemi, H. Kim, G. Reifenberger, S. Krajewski, J. C. Reed: Expression of Bcl-2 family member Bid in normal and malignant tissues. In: Neoplasia. 4, Nr

List of compositions by Elisabeth Lutyens (724 words) [view diff] no match in snippet view article find links to article

2807-01 LP: Argo ZRG 622 (1969) CD: Lyrita SRCD.265 (2008) pic.2.2.ca.Ebcl.2.bcl.2.cbsn-4.3.3.1-timp.6perc(2s.d, b.d, ten d, 5cym, 4tam-t, 3tamb, 3tri, tub

Said Sebti (927 words) [view diff] exact match in snippet view article find links to article

selective STAT3 signaling pathway inhibitor. Bcl/Mcl. The MCL1 member of the Bcl-2 family interests Sebti due to its role in preventing apoptosis. The Sebti

Apolipoprotein L1 (2,970 words) [view diff] exact match in snippet view article find links to article

Liu Z, Kaini R, Jiang Z, Hu CA (August 2008). "Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death"

Trypanosoma brucei (12,738 words) [view diff] exact match in snippet view article find links to article

are normally involved in host apoptosis or autophagic death and possess a Bcl-2 homology domain 3. ApoL1 has been identified as the toxic component involved

Histopathologic diagnosis of prostate cancer (1,649 words) [view diff] exact match in snippet view article find links to article

HMCK(34βE12)+ Typically CK20−/CK7+, but CK7− in pure solid basal cell nests Bcl-2+, strongly and diffusely Ki-67 nuclear staining in >20% Not recommended

Humanin (2,141 words) [view diff] exact match in snippet view article find links to article

lab found humanin when screening for proteins that could interact with Bcl-2-associated X protein (Bax), a major protein involved in apoptosis. The Pinchas

Adenovirus early region 1A (2,233 words) [view diff] exact match in snippet view article find links to article

E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins". Proceedings of the National Academy of Sciences of the United

Caspase-activated DNase (3,047 words) [view diff] exact match in snippet view article find links to article

J, Metcalf D, Ekert PG, et al. (October 2002). "Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9

Tubulin beta-3 chain (3,140 words) [view diff] exact match in snippet view article find links to article

Campiani G, Scambia G (1 September 2009). "Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77". Cancer Research. 69 (17): 6906–14

Auditory fatigue (3,758 words) [view diff] exact match in snippet view article find links to article

Minami, Shujiro B.; Kanzaki, Sho; Ogawa, Kaoru; Miller, Josef M. (2008). "Bcl-2 genes regulate noise-induced hearing loss". Journal of Neuroscience Research

Major facilitator superfamily (5,028 words) [view diff] exact match in snippet view article find links to article

Yamamoto D (July 2003). "HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death". Cell Death

Eltanexor (482 words) [view diff] exact match in snippet view article find links to article

Cytarabine) with E.V.A. (Eltanexor, Venetoclax, and A1210477) Inhibiting XPO1, Bcl-2, and Mcl-1". Cells. 13 (7): 632. doi:10.3390/cells13070632. PMC 11011525

AI-10-49 (2,849 words) [view diff] exact match in snippet view article find links to article

Armstrong RC, Augeri DJ, Belli BA, et al. (June 2005). "An inhibitor of Bcl-2 family proteins induces regression of solid tumours". Nature. 435 (7042):

Laura Niedernhofer (1,677 words) [view diff] case mismatch in snippet view article find links to article

"Identification of a novel senolytic agent, navitoclax, targeting the BCL-2 family of anti-apoptotic factors". Aging Cell. 15 (3): 428–435. doi:10.1111/acel

Cladosporium oxysporum (2,291 words) [view diff] exact match in snippet view article find links to article

line by suppressing growth, and down-regulating the expression of NF-B, Bcl-2 and Bcl-XL and up-regulation of pro-apoptotic proteins like Bax, cyt-C and

Gene therapy for osteoarthritis (5,381 words) [view diff] exact match in snippet view article find links to article

Signaling molecule/transcription factor Smad, Sox-9, IkB Apoptosis Inhibitor Bcl-2 Extra cellular matrix molecule Type II collagen, COMP Free radical antagonist

Senescence-associated secretory phenotype (4,556 words) [view diff] case mismatch in snippet view article find links to article

of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors". Nutrition. 65: 33–38. doi:10.1016/j.nut.2019.01.020

Boron porphyrins (1,804 words) [view diff] no match in snippet view article find links to article

The computed structure of (BCl)2(por) gives a B-B bond length of 1.74 Å, a tetragonal porphyrin elongation of 0.84 Å. The halides adopt a transoid configuration

Tafazzin (6,767 words) [view diff] exact match in snippet view article find links to article

and other machinery involved with its interactions with members of the Bcl-2 family, caspases, Bid, Bax, and Bak. Mutations in the TAFAZZIN gene have

Ultrasensitivity (8,823 words) [view diff] exact match in snippet view article find links to article

Another model also showed similar but different positive feedback controls in Bcl-2 family proteins in apoptotic process. Recently, Jeyeraman et al. have proposed

Kevin A. Roth (745 words) [view diff] exact match in snippet view article find links to article

2010 Jan 27. PMID 20406898; PMCID: PMC2940627 Akhtar RS, Ness JM, Roth KA. Bcl-2 family regulation of neuronal development and neurodegeneration. Biochim

CUSP9 (1,478 words) [view diff] exact match in snippet view article find links to article

Debatin KM, Wirtz CR, Siegelin MD, Karpel-Massler G (September 2019). "Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic

Cell cycle withdrawal (2,198 words) [view diff] exact match in snippet view article find links to article

demolition under the presence of apoptotic signals, such as caspase proteins and Bcl-2 family regulation proteins. Before such process, the cell cycle withdrawal

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leading to gasdermin E (GSDME)-dependent pyroptosis and release of IL-1α. The BCL-2 family members MCL-1 and BCL-xL were identified as the pyroptosis-inducing

Tris(silox)tantalum (1,317 words) [view diff] no match in snippet view article

Tantalum-to-Boron Dative Interactions in (silox) 3 Ta(BH 3 ) and (silox) 3 Ta(η 2 -B,Cl-BCl 2 Ph) (silox = t Bu 3 SiO) 1". Inorganic Chemistry. 46 (4): 1222–1232. doi:10

LL-100 panel (4,749 words) [view diff] exact match in snippet view article find links to article

S; Minden, MD; Messner, HA (September 1995). "p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines". Leukemia & Lymphoma

Lee Byung-heon (biochemist) (2,910 words) [view diff] exact match in snippet view article

PMID 16314050. Lee, B. H.; Ruoslahti, E. (2005). "Α5β1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and

Death regulator Nedd2-like caspase (4,796 words) [view diff] exact match in snippet view article find links to article

class Mammalia, the balance between members of the pro- and anti-apoptotic Bcl-2 family is a key factor in the commitment to apoptosis by regulating the

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Anthony; Mathew, Susan; Singh, Ankur (2020-10-27). "Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes"

2024–25 Basketball Champions League (1,441 words) [view diff] no match in snippet view article find links to article

Rank National Federation Coeff. Teams 1 Spain 103.40 4+1 BCL 2 Israel 71.67 2 3 France 70.16 3 4 Turkey 65.20 4 5 Greece 60.75 5 6 Germany 60.50