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searching for Senolytic 16 found (55 total)

alternate case: senolytic

Panobinostat (1,358 words) [view diff] exact match in snippet view article find links to article

as a potential drug candidate. Panobinostat was also identified as a senolytic, effective at killing senescent cells. "Prescription medicines: registration

Laura Niedernhofer (1,680 words) [view diff] exact match in snippet view article find links to article

(2015). "The Achilles' heel of senescent cells: From transcriptome to senolytic drugs". Aging Cell. 14 (4): 644–658. doi:10.1111/acel.12344. PMC 4531078

Genetics of aging (2,844 words) [view diff] exact match in snippet view article find links to article

Kirkland in collaboration with Scripps and other groups demonstrated that senolytics, drugs that target senescent cells, enhance cardiac function and improve

Laura Deming (908 words) [view diff] exact match in snippet view article find links to article

Longevity Fund investments include Unity Biotechnology, which develops senolytic drugs targeting diseases of aging, Navitor Pharmaceuticals, and Metacrine

Urokinase receptor (1,147 words) [view diff] exact match in snippet view article find links to article

Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, et al. (July 2020). "Senolytic CAR T cells reverse senescence-associated pathologies". Nature. 583 (7814):

Age management medicine (803 words) [view diff] exact match in snippet view article find links to article

Medicine (A4M), co-founded by Dr. Robert M. Goldman and Ronald Klatz. Senolytic (from the words senescence and -lytic, "destroying") is a member of a

Insilico Medicine (1,753 words) [view diff] exact match in snippet view article find links to article

3389/fnagi.2022.914017. PMC 9273868. PMID 35837482. Sabry, Fouad (2022). Senolytic: Selectively induce death of senescent cells to improve humans' health

Dasatinib (1,994 words) [view diff] exact match in snippet view article find links to article

"Dasanix". Medex. Retrieved 19 May 2021. Kirkland JL, Tchkonia T (2020). "Senolytic drugs: from discovery to translation". Journal of Internal Medicine. 288

Disease-modifying osteoarthritis drug (2,378 words) [view diff] exact match in snippet view article find links to article

Clinical Outcomes Following Single-Dose IA Administration of UBX0101, a Senolytic MDM2/p53 Interaction Inhibitor, in Patients with Knee OA". ACR Meeting

EF-24 (307 words) [view diff] exact match in snippet view article find links to article

Zheng G, Zhou D (January 2019). "The curcumin analog EF24 is a novel senolytic agent". Aging. 11 (2): 771–782. doi:10.18632/aging.101787. PMC 6366974

Arlan Richardson (1,249 words) [view diff] exact match in snippet view article find links to article

"Necroptosis contributes to chronic inflammation and fibrosis in aging liver". "Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice

Α-Ketoglutaric acid (4,985 words) [view diff] exact match in snippet view article find links to article

Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA (February 2023). "Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation

GDF11 (3,980 words) [view diff] exact match in snippet view article find links to article

humans—is unclear and continues to be researched. GDF11 is a powerful senolytic and antioxidant. GDF11 fed mice saw 45.7% reduction in senescent liver

MTOR (12,682 words) [view diff] exact match in snippet view article find links to article

Santarelli L, et al. (2018). "Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant

Extracellular vesicle (6,967 words) [view diff] exact match in snippet view article find links to article

vascular endothelial inflammation and promote atherosclerosis. EVs also have senolytic potential. EVs harvested from cardio-sphere-derived cells in young rats

Resibufogenin (2,822 words) [view diff] exact match in snippet view article find links to article

"Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice". Biogerontology