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searching for MTOR 211 found (764 total)

alternate case: mTOR

RHEB (2,652 words) [view diff] exact match in snippet view article find links to article

expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle. RHEB is a recently discovered
Branched-chain amino acid (3,250 words) [view diff] exact match in snippet view article find links to article
the mTOR pathway also plays a role in beta cell growth leading to insulin secretion. High glucose in the blood begins the process of the mTOR signaling
Focal cortical dysplasia (700 words) [view diff] exact match in snippet view article find links to article
mammalian target of rapamycin (mTOR) pathway. Causative gene mutations for types 1 and 3 have not been identified. The mTOR pathway regulates a number of
Nathanael Gray (253 words) [view diff] exact match in snippet view article find links to article
has made are Torin1, an ATP-competitive mTOR inhibitor, BMK1, an inhibitor of ERK5, and inhibitors of EGFR, mTor, Bcr-Abl, Mps1, Erk5, b-Raf and Ephrin
EIF4EBP1 (2,408 words) [view diff] exact match in snippet view article find links to article
shown to interact with: EIF4E, KIAA1303, and Mammalian target of rapamycin (mTOR). GRCh38: Ensembl release 89: ENSG00000187840 - Ensembl, May 2017 GRCm38:
Akt/PKB signaling pathway (4,115 words) [view diff] exact match in snippet view article find links to article
feedback loop. Akt promotes cyclin D1 translation via indirect activation of mTOR. mTOR increases translation of cyclin D1 by activating ribosomal protein S6K
EIF4E (3,079 words) [view diff] exact match in snippet view article find links to article
synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Mol. Cell. Biol. 26 (10): 3955–65
MLST8 (801 words) [view diff] exact match in snippet view article find links to article
subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and
Insulin-like growth factor 1 (3,410 words) [view diff] exact match in snippet view article find links to article
regulated by phosphatidylinositol-3 kinase (PI3K) and its downstream partner, mTOR (mammalian Target of Rapamycin). Rapamycin binds with the enzyme FKBPP12
TSC2 (1,836 words) [view diff] exact match in snippet view article find links to article
Cantley LC (July 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. PMID 15261145
Dactolisib (596 words) [view diff] exact match in snippet view article find links to article
imidazoquinoline derivative acting as a PI3K inhibitor. It also inhibits mTOR. It is being investigated as a possible cancer treatment. It has been shown
Meritor (497 words) [view diff] exact match in snippet view article find links to article
Meritor, Inc. (NYSE: MTOR) is an American corporation headquartered in Troy, Michigan, which manufactures automobile components for military suppliers
Geraniin (442 words) [view diff] exact match in snippet view article find links to article
anticancer activity and shown to target apoptosis via inactivation of PI3K/Akt/mTOR signaling pathway involving NF-κB when treated against HT-29 human colorectal
Farnesyltransferase inhibitor (1,079 words) [view diff] exact match in snippet view article find links to article
molecules are called FTIs (or farnesyl-transferase inhibitors). As with mTOR inhibitors, many companies developed them to treat cancers, where they were
DEPTOR (859 words) [view diff] exact match in snippet view article find links to article
DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by
Caloric restriction mimetic (2,757 words) [view diff] exact match in snippet view article find links to article
Rapamycin (mTOR) pathway, might be a CR mimetic. based on the responsiveness of mTORC1 activity to nutrient availability; the fact that mTOR activity is
Eukaryotic initiation factor 4F (681 words) [view diff] exact match in snippet view article find links to article
eIF4F is an important target of mTOR signaling through the eIF4E binding protein (4E-BP). Phosphorylation of 4E-BPs by mTOR prevents their binding to eIF4E
Oleocanthal (1,341 words) [view diff] exact match in snippet view article find links to article
downregulation of phosphorylated mTOR in metastatic breast cancer cell line (MDA-MB-231). These results strongly indicate that mTOR inhibition is at least one
Oleocanthal (1,341 words) [view diff] exact match in snippet view article find links to article
downregulation of phosphorylated mTOR in metastatic breast cancer cell line (MDA-MB-231). These results strongly indicate that mTOR inhibition is at least one
ATC code L01 (715 words) [view diff] no match in snippet view article find links to article
ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes
Fibrosis (1,029 words) [view diff] exact match in snippet view article find links to article
10 (IL-10). These initiate signal transduction pathways such as the AKT/mTOR and SMAD pathways that ultimately lead to the proliferation and activation
1-alpha-O-Galloylpunicalagin (140 words) [view diff] exact match in snippet view article find links to article
production in a dose-dependent manner in endothelial cells via the PI3K/AKT/mTOR pathway. Combreglutinin, a Hydrolyzable Tannin from Combretum glutinosum
Folliculin (5,373 words) [view diff] exact match in snippet view article find links to article
regulator of mechanistic target of rapamycin (mTOR) suggesting that FLCN and FNIP1 may play a role in modulating mTOR activity through energy or nutrient sensing
Sapanisertib (321 words) [view diff] exact match in snippet view article find links to article
MLN0128, INK128 and TAK-228) is an experimental small molecule inhibitor of mTOR which is administered orally. It targets both mTORC1 and mTORC2. Developed
Eukaryotic initiation factor 3 (2,101 words) [view diff] exact match in snippet view article find links to article
cellular signaling through S6K1 and mTOR/Raptor. In particular, eIF3 is bound by S6K1 in its inactive state, and activated mTOR/Raptor binds to eIF3 and phosphorylates
Tuberous sclerosis protein (1,070 words) [view diff] exact match in snippet view article find links to article
acts as an important integrator of different signaling pathways controlling mTOR signaling, by regulating especially mTORC1 activity. TSC2 contains a GTPase
EIF3B (927 words) [view diff] exact match in snippet view article find links to article
9 eta, 116kDa". Holz MK, Ballif BA, Gygi SP, Blenis J (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through
Tuberous sclerosis (5,383 words) [view diff] exact match in snippet view article find links to article
An mTOR inhibitor drug can help, though a lung transplant may be required. A 12-lead ECG should be performed every three to five years. The mTOR inhibitor
MAPKAP1 (785 words) [view diff] exact match in snippet view article find links to article
is encoded by the MAPKAP1 gene. As the name indicates, it is a subunit of mTOR complex 2. This gene encodes a protein that is highly similar to the yeast
Voxtalisib (280 words) [view diff] exact match in snippet view article find links to article
phosphatidylinositol 3-kinase (PI3K) and mechanistic target of rapamycin (mTOR). It is in clinical trials for the treatment of various types of cancer.
Stuart Schreiber (2,663 words) [view diff] exact match in snippet view article find links to article
regulator of nutrient sensing, mTOR. They found that the small molecule rapamycin simultaneously binds FKBP12 and mTOR (originally named FKBP12-rapamycin
LAMTOR4 (83 words) [view diff] exact match in snippet view article find links to article
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 is a protein that in humans is encoded by the LAMTOR4 gene. GRCh38: Ensembl release 89: ENSG00000188186
Ovarian follicle activation (3,981 words) [view diff] exact match in snippet view article find links to article
primordial follicles. It does this by negatively controlling the PI3K/AKT/mTOR pathway. This particular action of PTEN was initially discovered in an experiment
Torin-1 (637 words) [view diff] exact match in snippet view article find links to article
first non-rapalog derived inhibitors of the mechanistic target of rapamycin (mTOR) subtypes mTORC1 and mTORC2. In animal studies it has anti-inflammatory,
Kun-Liang Guan (614 words) [view diff] exact match in snippet view article find links to article
the mammalian target of rapamycin (mTOR), which is a central cell growth controller conserved from yeast to human. mTOR integrates a wide range of signals
Michael N. Hall (825 words) [view diff] case mismatch in snippet view article find links to article
http://medicine.uchicago.edu/events/106th-howard-taylor-ricketts-lecture-mtor-signaling-in-growth-and-metabolism/ https://www.hfsp
BTRC (gene) (3,341 words) [view diff] exact match in snippet view article
for the ribosome. βTrCP also cooperates with mTOR and CK1α to induce the degradation of DEPTOR (an mTOR inhibitor), thereby generating an auto-amplification
Phosphatidylinositol-4,5-bisphosphate 3-kinase (298 words) [view diff] case mismatch in snippet view article find links to article
metabolism, erbb signaling pathway, phosphatidylinositol signaling system, mtor signaling pathway, apoptosis, VEGF signaling pathway, focal adhesion, toll-like
Low-protein diet (3,262 words) [view diff] exact match in snippet view article find links to article
sensing of amino acid availability by they mammalian target of rapamycin (mTOR), two systems that are implicated in longevity and cancer proliferation.
XL-388 (326 words) [view diff] exact match in snippet view article find links to article
selective inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for the treatment of various
JAK-STAT signaling pathway (6,571 words) [view diff] exact match in snippet view article find links to article
to interconnect with other cell-signalling pathways, such as the PI3K/AKT/mTOR pathway. When JAKs are activated and phosphorylate tyrosine residues on receptors
Midkine (2,364 words) [view diff] exact match in snippet view article find links to article
versus WT cells, seemed to activate PKB (Akt), mTOR, and Bad protein, while it inactivated caspase-3. PKB, mTOR, and Bad are all elements associated with the
Eukaryotic translation initiation factor 4 gamma 1 (1,635 words) [view diff] exact match in snippet view article find links to article
synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Molecular and Cellular Biology. 26
Midkine (2,364 words) [view diff] exact match in snippet view article find links to article
versus WT cells, seemed to activate PKB (Akt), mTOR, and Bad protein, while it inactivated caspase-3. PKB, mTOR, and Bad are all elements associated with the
MEK inhibitor (719 words) [view diff] exact match in snippet view article find links to article
Kathy (2016-11-29). "In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC". Oncotarget. 7 (48): 79526–79543
FBXW11 (3,034 words) [view diff] exact match in snippet view article find links to article
translation and cell growth. βTrCP also cooperates with mTOR and CK1α to induce the degradation of DEPTOR (an mTOR inhibitor), thereby generating an auto-amplification
Eukaryotic initiation factor (1,621 words) [view diff] exact match in snippet view article find links to article
their translation. eIF3 also mediates cellular signaling through S6K1 and mTOR/Raptor to effect translational regulation. The eIF4F complex is composed
CAD protein (1,151 words) [view diff] exact match in snippet view article find links to article
"Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1". Science. 339 (6125): 1323–8. Bibcode:2013Sci...339.1323B. doi:10
FRS2 (1,851 words) [view diff] exact match in snippet view article find links to article
multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways. It is overexpressed and amplified in several cancer types
SR protein (3,444 words) [view diff] exact match in snippet view article find links to article
transcript to auto-regulate the concentration of SR proteins. Through the mTOR pathway and interactions with polyribosomes, SR proteins can increase translation
Interleukin 27 (668 words) [view diff] exact match in snippet view article find links to article
inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected
Drug-eluting stent (4,869 words) [view diff] exact match in snippet view article find links to article
to be approved in Europe and the U.S. were coated with paclitaxel or an mTOR inhibitor, such as sirolimus. Clinical trials have shown the benefits of
STAT3 (3,285 words) [view diff] exact match in snippet view article find links to article
shown to interact with: AR, ELP2, EP300, EGFR, HIF1A, JAK1, JUN KHDRBS1, mTOR, MYOD1, NDUFA13, NFKB1, NR3C1, NCOA1, PML, RAC1, RELA, RET, RPA2, STAT1,
Endometrial cancer (10,220 words) [view diff] exact match in snippet view article find links to article
inhibit the mTOR pathway may reduce the risk of disease worsening compared to having more chemotherapy or hormonal therapy. Though, mTOR inhibitors may
U0126 (395 words) [view diff] exact match in snippet view article find links to article
extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR)-p70(S6K) pathways. The effects of U0126 on the growth of eight human breast
UBQLN1 (1,411 words) [view diff] exact match in snippet view article find links to article
including UBQLN2 and UBQLN4. UBQLN1 has been shown to interact with HERPUD1, MTOR, P4HB, PSEN1 PSEN2, and UBE3A. TMCO6, GRCh38: Ensembl release 89: ENSG00000135018
Signal transducing adaptor protein (663 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Exon junction complex (2,444 words) [view diff] exact match in snippet view article find links to article
speckled domains has been measured recently and it may be regulated by PI3K/AKT/mTOR signaling pathways. In order for the binding of the complex to the mRNA to
Autoimmune lymphoproliferative syndrome (2,410 words) [view diff] exact match in snippet view article find links to article
requiring IVIgG replacement. Sirolimus (rapamycin, rapamune) which is a mTOR (mammalian target of rapamycin) inhibitor can be active in most patients
Peroxiredoxin 1 (1,683 words) [view diff] exact match in snippet view article find links to article
that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma. The expression patterns
Contact inhibition (2,205 words) [view diff] exact match in snippet view article find links to article
contact-inhibited cells must activate growth-activating pathways such as mTOR. Once cells in high-density cultures become confluent enough such that the
Anaplastic large-cell lymphoma (5,217 words) [view diff] exact match in snippet view article find links to article
ALK is a serine/threonine-specific protein kinase that activities PI3K/AKT/mTOR, Ras-activated ERKs, Janus kinase-activated STAT proteins, and other cell
MiR-218 microRNA precursor family (477 words) [view diff] exact match in snippet view article find links to article
J (September 2011). "The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer". Cancer
KLF15 (2,779 words) [view diff] exact match in snippet view article find links to article
genes of the glucocorticoid receptor (GR) in skeletal muscle. KLF15 inhibits mTOR activity via a distinct mechanism involving BCAT2 gene activation. KLF15
Disposable soma theory of aging (4,375 words) [view diff] exact match in snippet view article find links to article
chaperones, and heat-shock proteins. Additionally, uptake of IGF-1 stimulates the mTOR pathway, which activates protein synthesis (and therefore growth) through
EIF3F (998 words) [view diff] exact match in snippet view article find links to article
Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO
Fisetin (1,959 words) [view diff] exact match in snippet view article find links to article
model animals conducted in laboratories, and appears to block the PI3K/AKT/mTOR pathway, along with other mechanisms to induce apoptosis activation, and
Tumor metabolome (2,558 words) [view diff] exact match in snippet view article find links to article
The protein AKT1 (also known as Protein Kinase B or PKB) in the PI3K/AKT/mTOR pathway is an important driver of the tumor glycolytic phenotype and stimulates
ZFP36L1 (792 words) [view diff] exact match in snippet view article find links to article
Gene: ZFP36L1 zinc finger protein 36, C3H type-like 1". Weichhart T (2018). "mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review"
Manlio Vinciguerra (284 words) [view diff] exact match in snippet view article find links to article
processes, stress and aging in the heart and in the liver, such as PI3K/AKT/mTOR pathway and sirtuins, using a systems biology approach in cells and rodent
EIF4B (954 words) [view diff] exact match in snippet view article find links to article
Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N (2006). "The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and
Intracellular receptor (111 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
HY-124798 (335 words) [view diff] exact match in snippet view article find links to article
acts as an endogenous activator of the mechanistic target of rapamycin (mTOR) subtype mTORC1. Since many of the side effects of rapamycin and its analogues
D2-like receptor (63 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
WYE-687 (198 words) [view diff] exact match in snippet view article find links to article
as an inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for potential applications in
Immunosuppression (928 words) [view diff] exact match in snippet view article find links to article
immunodeficiency of T-cells.). Immunosuppressive drug Discovery and development of mTOR inhibitors BK virus Interleukin-2 immunotherapy B cell deficiency T cell
ML-SI3 (377 words) [view diff] exact match in snippet view article find links to article
"Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR". PLoS Biology. 17 (5): e3000252. doi:10.1371/journal.pbio.3000252. PMID 31112550
Cobimetinib (957 words) [view diff] exact match in snippet view article find links to article
Kathy (2016-11-29). "In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC". Oncotarget. 7 (48): 79526–79543
ATL-444 (157 words) [view diff] exact match in snippet view article find links to article
Kim CS (May 2018). "Adenosine induces intrinsic apoptosis via the PI3K/Akt/mTOR signaling pathway in human pharyngeal squamous carcinoma FaDu cells". Oncology
Duvelisib (721 words) [view diff] exact match in snippet view article find links to article
repair, senescence, angiogenesis and cell metabolism, including the PI3K/AKT/mTOR pathway. Duvelisib, also known as IPI-145, was discovered by Intellikine
ULK1 (1,855 words) [view diff] exact match in snippet view article find links to article
ULK1 is phosphorylated by AMPK on Ser317 and Ser777 to activate autophagy; mTOR participates in inhibitory phosphorylation of ULK1 on Ser757. Additionally
Transcription factor II F (321 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
D1-like receptor (61 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Follicular dendritic cell sarcoma (2,537 words) [view diff] exact match in snippet view article find links to article
studies have also shown that doxorubicin may be involved in the PI3K/AKT/mTOR pathway. An important hallmark of cancer, Akt is part of the cell survival
Phosphorylation (1,763 words) [view diff] exact match in snippet view article find links to article
(2007-10-01). "Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart". Cardiovascular Research. 76 (1): 71–80. doi:10
Combination therapy (998 words) [view diff] exact match in snippet view article find links to article
(2014-01-30). "Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors". Cell Reports. 6 (2): 377–387. doi:10.1016/j.celrep.2013.12.035
Transcription factor II D (574 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Lhermitte–Duclos disease (492 words) [view diff] exact match in snippet view article find links to article
in PTEN gene on chromosome no. 10q leads to increased activity of AKT and mTOR pathways. Treatment is not needed in the asymptomatic patient. Symptomatic
Restriction point (2,720 words) [view diff] exact match in snippet view article find links to article
degradation of cyclin D1 (see figure). Akt further regulates G1/S components by mTOR-mediated promotion of cyclin D1 translation, phosphorylation of the Cdk inhibitors
Transcription factor II E (367 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Tikona Infinet Limited (440 words) [view diff] exact match in snippet view article find links to article
synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition". PLOS One. 8 (8): e71138. Bibcode:2013PLoSO...871138C. doi:10
Endocrine therapy resistance in breast cancer (3,207 words) [view diff] exact match in snippet view article find links to article
downregulated when there is activation of growth factors via the PI3K/Akt/mTOR pathway. Over-expression of HER2 is found to be present in around 30% of
TRIM28 (2,250 words) [view diff] exact match in snippet view article find links to article
heterochromatin formation prevents the transcription of the viral genome. mTOR has been implicated in the phosphorylation of KAP1 resulting in a switch
Fayaz A. Malik (1,605 words) [view diff] exact match in snippet view article find links to article
Suresh; Katoch, Meenu; Bhushan, Shashi (2013). "Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential
COASY (894 words) [view diff] exact match in snippet view article find links to article
interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Letters. 578 (3):
Exercise (13,650 words) [view diff] exact match in snippet view article find links to article
"The neurology of mTOR". Neuron. 84 (2): 275–91. doi:10.1016/j.neuron.2014.09.034. PMC 4223653. PMID 25374355. Figure 2: The mTOR Signaling Pathway Wang
GSPT1 (1,141 words) [view diff] exact match in snippet view article find links to article
depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway". Molecular and Cellular Biology. 27 (16): 5619–29. doi:10.1128/MCB
Lipofibromatosis (1,807 words) [view diff] exact match in snippet view article find links to article
proto-oncogene receptor, respectively, all of which activate the PI3K/AKT/mTOR pathway; 2) the BRAF and ROS1 genes code for serine/threonine-protein kinase
5-HT2 receptor (166 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
SHORT syndrome (254 words) [view diff] exact match in snippet view article find links to article
subunit of phosphatidylinositol 3-kinase. This mutation can alter the PI3K/AKT/mTOR signal route, which plays an important role in cell growth and proliferation
Juxtacrine signalling (612 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
FKBP1A (1,779 words) [view diff] exact match in snippet view article find links to article
muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science. 118 (Pt 23): 5443–51. doi:10.1242/jcs
Amino acid (10,280 words) [view diff] exact match in snippet view article find links to article
"The neurology of mTOR". Neuron. 84 (2): 275–291. doi:10.1016/j.neuron.2014.09.034. PMC 4223653. PMID 25374355. Figure 2: The mTOR Signaling Pathway Phillips
Eganelisib (382 words) [view diff] exact match in snippet view article find links to article
and thus works by inhibiting the enzyme PIK3CG, disrupting the PI3K/AKT/mTOR signaling pathway which plays important roles in the development of cancer
EIF3A (1,357 words) [view diff] exact match in snippet view article find links to article
TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO
Cell physiology (847 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Human genetic enhancement (1,742 words) [view diff] exact match in snippet view article find links to article
April 2010). "Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau". The Journal of Biological Chemistry. 285 (17): 13107–13120
AGPAT9 (562 words) [view diff] exact match in snippet view article find links to article
human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006
PELP-1 (3,891 words) [view diff] exact match in snippet view article find links to article
extra-nuclear actions by coupling ESR1 with Src kinase PI3K STAT3 ILK1 and mTOR PELP1 participates in E2-mediated cell proliferation and is a substrate of
Menerba (1,115 words) [view diff] exact match in snippet view article find links to article
"Timosaponin AIII is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress". PLOS ONE. 4 (9): e7283. Bibcode:2009PLoSO..
Mir-199 microRNA precursor (1,280 words) [view diff] exact match in snippet view article find links to article
Croce CM, Bolondi L, Gramantieri L (June 2010). "MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma
HEAT repeat (2,897 words) [view diff] exact match in snippet view article find links to article
(2010). "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes". Genes Dev. 24 (18): 2019–2030. doi:10.1101/gad.1956410
Neuroendocrine cell (907 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
ABTL0812 (267 words) [view diff] exact match in snippet view article find links to article
the PPAR receptors and the TRIB3 gene, leading to inhibition of the Akt/mTOR pathway. This pathway is excessively activated in most human cancers, supporting
Ghrelin (4,141 words) [view diff] exact match in snippet view article find links to article
communication pathways are probable, including the gastric intracellular mTOR/S6K1 pathway mediating the interaction among ghrelin, nesfatin and endocannabinoid
MLX (gene) (969 words) [view diff] exact match in snippet view article
Wilde BR, Ayer DE (2015). "MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction". Molecular and Cellular Biology. 35 (1): 101–110. doi:10
Prolactin receptor (1,859 words) [view diff] exact match in snippet view article find links to article
connect PRLR to the Ras/Raf/MAP kinase cascade JAK-RUSH pathway PI3K/AKT/mTOR pathway Expression of the PRLR protein is found within cells of the mammary
Transcription preinitiation complex (935 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Euglenophycin (2,627 words) [view diff] exact match in snippet view article find links to article
anti-cancer potential. This may be caused by inhibiting the mTOR pathway because it is known that the mTOR pathway can have a significant effect on stimulating
Amino acid neurotransmitter (191 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Oncolytic AAV (1,340 words) [view diff] exact match in snippet view article find links to article
also been investigated in combination with AAV-2-mTOR which targets the mammalian target of rapamycin (mTOR), an investigated anti-cancer target. AAV-DC-CTL:
Rapt (175 words) [view diff] exact match in snippet view article find links to article
the float plane industry being developed by Tigerfish Aviation RAPT1 or mTOR, the mammalian target of rapamycin protein RATP Group (Régie Autonome des
Neuropeptide (1,728 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Neuropeptide (1,728 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Rapt (175 words) [view diff] exact match in snippet view article find links to article
the float plane industry being developed by Tigerfish Aviation RAPT1 or mTOR, the mammalian target of rapamycin protein RATP Group (Régie Autonome des
Right ventricular hypertrophy (1,705 words) [view diff] exact match in snippet view article find links to article
only cause of RVH. Hypertrophy can also be caused by mechanical forces, mTOR pathways, nitric oxide and immune cells. Immune cells can cause hypertrophy
ARID1A (1,591 words) [view diff] exact match in snippet view article find links to article
expression confers resistance to different drugs such as trastuzumab and mTOR inhibitors. These findings provide a rationale for why tumors accumulate
5-HT1 receptor (163 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Second messenger system (1,338 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
ITPR1 (1,655 words) [view diff] exact match in snippet view article find links to article
muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science. 118 (Pt 23): 5443–51. doi:10.1242/jcs
Transforming growth factor beta family (579 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Facial infiltrating lipomatosis (783 words) [view diff] exact match in snippet view article find links to article
drug treatment options are either a mTOR inhibitor, a pan AKT (AKT1-2-3) inhibitor or a PIK3CA inhibitor. The mTOR inhibitor is an off-label use, the use
Autocrine signaling (2,096 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Diffuse large B-cell lymphoma (7,922 words) [view diff] exact match in snippet view article find links to article
neoplastic cells in DLBCL, NOS exhibit pathologically overactive NF-κB, PI3K/AKT/mTOR, JAK-STAT0, MAPK/ERK, B-cell receptor, toll-like receptor, and NF-κB signaling
Joan Brugge (1,313 words) [view diff] exact match in snippet view article find links to article
L Song, FC Morales, S Gao, GB Mills and JS Brugge. "Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells." Cancer Cell
Uterine cancer (1,845 words) [view diff] exact match in snippet view article find links to article
endometrial cancer. Targeted therapy may include monoclonal antibodies, mTOR inhibitors, and signal transduction inhibitors which all act to target cancer
PDIA3 (1,182 words) [view diff] exact match in snippet view article find links to article
it to serve as a redox sensor by activating mTORC1, which then mediates mTOR complex assembly to adapt cells to oxidative damage. Thus, PDIA3 regulates
Sigma-2 receptor (1,488 words) [view diff] exact match in snippet view article find links to article
calcium. Known effects include decrease of expression of effectors in the mTOR pathway, and suppression of cyclin D1 and PARP-1. Signaling action in neurons
PDIA3 (1,182 words) [view diff] exact match in snippet view article find links to article
it to serve as a redox sensor by activating mTORC1, which then mediates mTOR complex assembly to adapt cells to oxidative damage. Thus, PDIA3 regulates
Sigma-2 receptor (1,488 words) [view diff] exact match in snippet view article find links to article
calcium. Known effects include decrease of expression of effectors in the mTOR pathway, and suppression of cyclin D1 and PARP-1. Signaling action in neurons
Autophagy-related protein 13 (833 words) [view diff] exact match in snippet view article find links to article
Jung CH, Jun CB, Ro SH, et al. (2009). "ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery". Mol. Biol. Cell. 20 (7): 1992–2003
Cell surface receptor (2,423 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Intracrine (787 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Apurva Sarin (593 words) [view diff] exact match in snippet view article find links to article
hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells". Cell
Trouble with Lichen (1,048 words) [view diff] exact match in snippet view article find links to article
Maecker, HT; Kovarik, J; Carson, S; Klickstein, LB (December 24, 2014). "mTOR inhibition improves immune function in the elderly". Sci Transl Med. 6 (268):
Cyclin E1 (1,705 words) [view diff] exact match in snippet view article find links to article
3840–4. PMID 12839982. Mayer C, Zhao J, Yuan X, Grummt I (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis
Apoptosis-inducing factor (1,120 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Calcium signaling (2,085 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
ZNF703 (1,127 words) [view diff] exact match in snippet view article find links to article
Researchers recently established a link between the trigger gene ZNF703 and Akt/mTOR pathway activation involved in the cellular cycle resulting in lung tumor
Naegleria fowleri (2,586 words) [view diff] exact match in snippet view article find links to article
inhibits the pathogen via disrupting its cell survival signal pathway PI3K/Akt/mTOR, has been used in a few cases with mixed results. A key factor to effective
Cytokine (3,662 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Central nervous system disease (2,300 words) [view diff] exact match in snippet view article find links to article
Retrieved 2013-10-30. Lipton JO, Sahin M (October 2014). "The neurology of mTOR". Neuron. 84 (2): 275–291. doi:10.1016/j.neuron.2014.09.034. PMC 4223653
ARIAD Pharmaceuticals (1,350 words) [view diff] exact match in snippet view article find links to article
Brigatinib was designated a Breakthrough Medicine by the FDA. Ridaforolimus is an mTOR inhibitor being developed by Medinol Ltd for use in drug-eluting stents for
Itraconazole (2,305 words) [view diff] exact match in snippet view article find links to article
Dang Y, Ren YR, Liu JO (2010). "Cholesterol trafficking is required for mTOR activation in endothelial cells". Proceedings of the National Academy of
Signaling Gateway (website) (319 words) [view diff] exact match in snippet view article
SBML. MIRIAM Registry Details. Robitaille, Aaron; Hall, Michael (2008). "MTOR". AfCS-Nature Molecule Pages. doi:10.1038/mp.a000094.01. Takemaru, Ken-Ichi
Alectinib (791 words) [view diff] exact match in snippet view article find links to article
subsequently blocks cell signalling pathways, including STAT3 and the PI3K/AKT/mTOR pathway, and induces death (apoptosis) of tumour cells. When taken with a
Apoptosis (10,357 words) [view diff] exact match in snippet view article find links to article
Necrobiosis Necrosis Necrotaxis Nemosis p53 Paraptosis Pseudoapoptosis PI3K/AKT/mTOR pathway Note that the average human adult has more than 13 trillion cells
Type I topoisomerase (2,336 words) [view diff] exact match in snippet view article find links to article
PMID 23377825. Dominick G, Bowman J, Li X, Miller RA, Garcia GG (2016). "mTOR regulates the expression of DNA damage response enzymes in long-lived Snell
Neuromodulation (2,372 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Beta-propeller (1,988 words) [view diff] exact match in snippet view article find links to article
"Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly". Nature Communications. 10 (1): 2865. Bibcode:2019NatCo
Companies listed on the New York Stock Exchange (M) (0 words) [view diff] exact match in snippet view article
Meredith Corporation MDP US Meritage Homes Corporation MTH US Meritor, Inc. MTOR US Merrill Lynch Capital Trust I MER.PRK US Merrill Lynch Capital Trust II
NAS Award in Molecular Biology (1,692 words) [view diff] exact match in snippet view article find links to article
M. Sabatini (2014) For his discovery of components and regulators of the mTOR kinase pathway and his elucidation of the important roles of this signaling
Johns Hopkins School of Medicine (2,532 words) [view diff] exact match in snippet view article find links to article
Sabatini – Howard Hughes Investigator and molecular biologist, discovered mTOR (mammalian target of rapamycin) Florence Sabin – Anatomist, namesake of Sabin
Apoptosis (10,357 words) [view diff] exact match in snippet view article find links to article
Necrobiosis Necrosis Necrotaxis Nemosis p53 Paraptosis Pseudoapoptosis PI3K/AKT/mTOR pathway Note that the average human adult has more than 13 trillion cells
Chrysophanol (1,423 words) [view diff] exact match in snippet view article find links to article
"Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway". Phytotherapy Research. 25 (6): 833–7. doi:10.1002/ptr.3323. PMID 21089180
Diet-induced obesity model (4,735 words) [view diff] exact match in snippet view article find links to article
high-fat/high-density diets and obesity, including the discovery of Akt and mTOR, signals in the body linked to obesity and insulin resistance. However, while
KHDRBS1 (2,809 words) [view diff] exact match in snippet view article find links to article
neurodevelopment disorders. Sam68 influences alternative splicing of the mTOR kinase contributing to the lean phenotype observed in the Sam68 deficient
TGF beta signaling pathway (2,043 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
List of antineoplastic agents (532 words) [view diff] exact match in snippet view article find links to article
anomalies, hypothyroidism and GI perforation (uncommon). 2.3 mTOR inhibitors Everolimus PO mTOR inhibitor. Renal cell cancer, pancreatic neuroendocrine tumour
MAPK/ERK pathway (3,094 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Animal model of autism (3,091 words) [view diff] exact match in snippet view article find links to article
many of the abnormalities found in autistic spectrum disorders involve the mTOR signaling pathway, the GABA - containing neurons, and the immune system.
Metabotropic glutamate receptor 2 (2,621 words) [view diff] exact match in snippet view article find links to article
ejphar.2008.06.089. PMID 18634781. Dwyer JM, Lepack AE, Duman RS (May 2012). "mTOR activation is required for the antidepressant effects of mGluR₂/₃ blockade"
Translation (biology) (3,288 words) [view diff] exact match in snippet view article
Several major oncogenic signaling pathways, including the RAS–MAPK, PI3K/AKT/mTOR, MYC, and WNT–β-catenin pathways, ultimately reprogram the genome via translation
Ligand (biochemistry) (3,134 words) [view diff] exact match in snippet view article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Extramammary Paget's disease (1,883 words) [view diff] exact match in snippet view article find links to article
nodes and venous system Proliferation at new site Protein molecules HER2 and mTOR expressed in Paget cells are responsible for providing characteristics of
Oncology (5,520 words) [view diff] exact match in snippet view article find links to article
options include surgery, multi-kinase inhibitors, and targeted therapy (mTOR & VEGF inhibitors). Bladder cancer Treatment options include surgery, radiation
RRN3 (529 words) [view diff] exact match in snippet view article find links to article
1016/S1097-2765(03)00036-4. PMID 12620228. Mayer C, Zhao J, Yuan X, Grummt I (2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis
NDRG1 (2,175 words) [view diff] exact match in snippet view article find links to article
Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, et al. (January 2014). "mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy"
STK25 (648 words) [view diff] exact match in snippet view article find links to article
(2007). "A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling". Biochem. J. 403 (1): 13–20. doi:10.1042/BJ20061881. PMC 1828895
Receptor (biochemistry) (2,567 words) [view diff] exact match in snippet view article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Receptor (biochemistry) (2,567 words) [view diff] exact match in snippet view article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Anne-Claude Gingras (1,025 words) [view diff] exact match in snippet view article find links to article
Anne-Claude (2001-04-01). "Regulation of translation initiation by FRAP/mTOR". Genes & Development. 15(7): 807–826. Sonenberg, Nahum; Aebersold, Ruedi;
Hormone (3,644 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Eukaryotic translation elongation factor 1 alpha 1 (2,664 words) [view diff] exact match in snippet view article find links to article
attributed to the resulting down-regulation of the PI3K/Akt/NF-κB and PI3K/Akt/mTOR signaling pathways. eEF1A1 is downregulated in myocardial infarction and
Scleroderma (3,511 words) [view diff] exact match in snippet view article find links to article
hearing loss) and progressive multifocal leucoencephalopathy. Sirolimus mTOR inhibitor, thereby reducing cytokine-induced lymphocyte proliferation. PO
Muscle hypertrophy (2,868 words) [view diff] exact match in snippet view article find links to article
Gonzalez M, Kline WO, Stover GL, Bauerlein R, et al. (November 2001). "Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent
Fiat (4,350 words) [view diff] case mismatch in snippet view article find links to article
years in a marketing deal. CMD – Costruzioni Motori Diesel S.p.A. "World Mtor Vehicle Production" (PDF). oica.net. 2010. Retrieved 13 September 2011. Hussain
Class III PI 3-kinase (478 words) [view diff] exact match in snippet view article find links to article
Sequestration of the Vps34 product by FYVE domain overexpression also disrupts mTOR signaling. However, genetic ablation of Vps34 in Drosophila does not affect
Transcription factor II B (2,438 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Aminoacyl tRNA synthetase (3,272 words) [view diff] exact match in snippet view article find links to article
inflammation, the immune response, the mechanistic target of rapamycin (mTOR) signalling, apoptosis, tumorigenesis, and interferon gamma (IFN-γ) and p53
STK25 (648 words) [view diff] exact match in snippet view article find links to article
(2007). "A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling". Biochem. J. 403 (1): 13–20. doi:10.1042/BJ20061881. PMC 1828895
Co-receptor (3,129 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
G protein (2,604 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Ras GTPase (3,661 words) [view diff] exact match in snippet view article find links to article
growth and division. Another Ras-activated signaling pathway is the PI3K/AKT/mTOR pathway, which stimulates protein synthesis and cellular growth, and inhibits
FGFR1OP (610 words) [view diff] exact match in snippet view article find links to article
by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways". Molecular and Cellular Biology. 21 (23): 8129–42. doi:10.1128/MCB
Sjöberg Prize (229 words) [view diff] exact match in snippet view article find links to article
Brian Druker American 2020 Michael N. Hall American “for their discovery of mTOR and its role in the control of cell metabolism and growth.” David M. Sabatini
Interleukin 13 (2,376 words) [view diff] exact match in snippet view article find links to article
stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway". Tumour Biology. 37 (11): 14701–14709. doi:10.1007/s13277-016-5346-x
Clusterin (2,440 words) [view diff] exact match in snippet view article find links to article
participates in to downplay apoptosis in tumor cells include the PI3K/AKT/mTOR pathway and NF-κB pathway. Unlike most other cancers, which feature upregulated
Bodybuilding supplement (3,317 words) [view diff] exact match in snippet view article find links to article
mechanisms, including activation of the mechanistic target of rapamycin (mTOR) and inhibition of the proteasome in skeletal muscles. The inhibition of
Hydroxynorketamine (1,487 words) [view diff] exact match in snippet view article find links to article
was found to increase the function of the mammalian target of rapamycin (mTOR), a marker of the antidepressant activity of ketamine, far more potently
HNRNPC (1,576 words) [view diff] exact match in snippet view article find links to article
response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling". FASEB J. 25 (3): 937–47. doi:10.1096/fj.10-172577. PMC 3042839
AKT1S1 (743 words) [view diff] exact match in snippet view article find links to article
SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology. 9 (3): 316–23
Visual phototransduction (1,887 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Scaffold protein (2,052 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
Treatment of cancer (7,227 words) [view diff] exact match in snippet view article find links to article
; Gately, Kathy (April 2014). "Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC". Cancer Treatment Reviews. 40 (3): 445–456. doi:10.1016/j
SESN2 (727 words) [view diff] exact match in snippet view article find links to article
monophosphate-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important
Integrin (3,670 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine
AEE788 (283 words) [view diff] exact match in snippet view article find links to article
tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma
Mantle cell lymphoma (3,438 words) [view diff] exact match in snippet view article find links to article
MCL. Other targeted agents include the proteasome inhibitor bortezomib, mTOR inhibitors such as temsirolimus, and the P110δ inhibitor GS-1101.[citation
RB1CC1 (1,047 words) [view diff] exact match in snippet view article find links to article
in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways". The Journal of Cell Biology. 175 (1): 121–33. doi:10
Receptor tyrosine kinase (3,069 words) [view diff] exact match in snippet view article find links to article
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents By distance Juxtacrine Autocrine / Paracrine