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searching for Genome instability 72 found (118 total)

alternate case: genome instability

SMC1A (2,075 words) [view diff] exact match in snippet view article find links to article

also takes part in DNA repair. The down-regulation of SMC1A causes genome instability, and CdLS cells carrying SMC1A variants display high level of chromosome
RMI1 (713 words) [view diff] exact match in snippet view article find links to article
RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene. During meiosis in budding yeast Saccharomyces cerevisiae
Stephen C. West (1,110 words) [view diff] exact match in snippet view article find links to article
DNA recombination and repair. He is known for pioneering studies on genome instability diseases including cancer. West obtained his BSc in 1974, and his
Micronucleus (1,959 words) [view diff] exact match in snippet view article find links to article
flawed anaphase checkpoint genes. Micronucleus can contribute to genome instability by promoting a catastrophic mutational event called chromothripsis
Jan Vijg (1,331 words) [view diff] exact match in snippet view article find links to article
the journal Aging published by Impact Journals (Albany, New York). Genome instability, i.e., the tendency of the genome to acquire mutations and epimutations
Ashok Venkitaraman (1,451 words) [view diff] exact match in snippet view article find links to article
biology of human cancer, particularly in elucidating the impact of genome instability on carcinogenesis and cancer therapy. He is best known for discovering
Inverted repeat (3,391 words) [view diff] exact match in snippet view article find links to article
pair with each other). These properties play an important role in genome instability and contribute not only to cellular evolution and genetic diversity
Applied Spectral Imaging (903 words) [view diff] exact match in snippet view article find links to article
in the identification and classification of chromosomal disorders, genome instability, various oncological malignancies, among other diseases. Founded in
Infectious causes of cancer (4,840 words) [view diff] no match in snippet view article find links to article
Estimates place the worldwide risk of cancers from infectious causes at 16.1%. Viral infections are risk factors for cervical cancer, 80% of liver cancers
ZMPSTE24 (588 words) [view diff] exact match in snippet view article find links to article
PMID 21701264. Gonzalo S, Kreienkamp R (2015). "DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome". Curr. Opin. Cell Biol. 34:
Breakage-fusion-bridge cycle (1,214 words) [view diff] exact match in snippet view article find links to article
type of malignant tumor. Although BFB cycles are a major source of genome instability, the rearrangement signature predicted by this model is not commonly
RecQ helicase (1,873 words) [view diff] exact match in snippet view article find links to article
PMC 5576896. PMID 27320928. Skouboe C, Bjergbaek L, Andersen AH (2005). "Genome instability as a cause of ageing and cancer: Implications of RecQ helicases".
RNASEH2B (1,306 words) [view diff] exact match in snippet view article find links to article
ribonucleotides can be highly deleterious to the mammalian cell, causing genome instability, and that the RNaseH2 is a critical enzyme for ensuring integrity
Bloom syndrome (2,573 words) [view diff] case mismatch in snippet view article find links to article
Hudson, Damien F.; et al. (15 December 2016). "Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome". PLOS Genet. 12 (12). e1006483.
Simon Boulton (1,889 words) [view diff] exact match in snippet view article find links to article
has allowed Boulton to make seminal contributions to DNA repair, genome instability, and cancer. Among Boulton's achievements is the discovery that the
SETX (1,814 words) [view diff] exact match in snippet view article find links to article
of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability". DNA Repair. 19: 84–94. doi:10.1016/j.dnarep.2014.03.023. PMC 4051866
Myung Kyungjae (977 words) [view diff] case mismatch in snippet view article find links to article
editor for Mutation Research, and been on the Editorial Board for Genome Instability and Disease, Genomics, Genome Integrity, and Molecular and Cellular
Mdm2 (4,311 words) [view diff] exact match in snippet view article find links to article
repair, chromosomal abnormalities, and genome instability. These data demonstrated Mdm2-induced genome instability can be mediated through Mdm2:Nbs1 interactions
Secreted frizzled-related protein 1 (6,274 words) [view diff] no match in snippet view article find links to article
Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene. Secreted frizzled-related protein
Personalized onco-genomics (3,289 words) [view diff] exact match in snippet view article find links to article
is currently being led by Dr. Marco Marra and Dr. Janessa Laskin. Genome instability has been identified as one of the underlying hallmarks of cancer. The
Nuclear envelope (2,081 words) [view diff] exact match in snippet view article find links to article
PMID 22567193. Lim; et al. (2016). "Nuclear envelope rupture drives genome instability in cancer". Molecular Biology of the Cell. MBoC. 27 (21): 3210–3213
Breakthrough Prize in Life Sciences (1,982 words) [view diff] exact match in snippet view article find links to article
illuminating how they protect chromosome ends and their role in genome instability in cancer. Napoleone Ferrara (University of California, San Diego)
Transcription factor II H (1,172 words) [view diff] case mismatch in snippet view article find links to article
PMID 14980221. S2CID 14312462. Edifizi D, Schumacher B (August 2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair
Recombination hotspot (1,079 words) [view diff] case mismatch in snippet view article find links to article
1042/BST0340526. PMID 16856851. Aguilera, A.; Gomez-Gonzalez, B. (2008). "Genome Instability: A Mechanistic View of Its Causes and Consequences". Nature Reviews
Titia de Lange (1,632 words) [view diff] exact match in snippet view article find links to article
illuminating how they protect chromosome ends and their role in genome instability in cancer by mapping the complex of molecules that loops the strands
PLK4 (2,205 words) [view diff] exact match in snippet view article find links to article
Snyder M, Sluder G, Holland AJ (July 2015). "p53 protects against genome instability following centriole duplication failure". The Journal of Cell Biology
Hoyeraal–Hreidarsson syndrome (556 words) [view diff] exact match in snippet view article find links to article
deficiency causes Hoyeraal–Hreidarsson syndrome with short telomeres and genome instability". Human Molecular Genetics. 22 (16): 3239–49. doi:10.1093/hmg/ddt178
Gene duplication (3,171 words) [view diff] exact match in snippet view article find links to article
a whole genome duplication, there is a relatively short period of genome instability, extensive gene loss, elevated levels of nucleotide substitution and
FANCM (1,747 words) [view diff] exact match in snippet view article find links to article
PMID 18206976. Deans AJ, West SC (December 2009). "FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia". Molecular Cell. 36
Ribonucleotide (2,573 words) [view diff] exact match in snippet view article find links to article
Lundström, EB; Johansson, E; Chabes, A; Kunkel, TA (October 2010). "Genome instability due to ribonucleotide incorporation into DNA". Nature Chemical Biology
Ribosome recycling factor (743 words) [view diff] exact match in snippet view article find links to article
cell nucleus. Loss of function of this gene leads to mitochondrial genome instability and respiratory incompetence. The crystal structure of RRF was first
Sirtuin 7 (1,205 words) [view diff] exact match in snippet view article find links to article
DSBs are one of the most significant types of DNA damage leading to genome instability. SIRT7 is recruited to DSBs where it specifically deacylates histone
Severe congenital neutropenia (1,940 words) [view diff] exact match in snippet view article find links to article
underlying molecular/genetic changes producing DNA mutations and genome instability, which contribute to initiation and progression of this disease.[citation
LMNA (2,698 words) [view diff] exact match in snippet view article find links to article
PMID 21701264. Gonzalo S, Kreienkamp R (2015). "DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome". Curr. Opin. Cell Biol. 34:
Richard Kolodner (630 words) [view diff] exact match in snippet view article find links to article
recombination, DNA mismatch repair and the pathways that prevent genome instability. While studying DNA repair in bacteria and yeast, Kolodner identified
Frataxin (2,709 words) [view diff] exact match in snippet view article find links to article
(December 2016). "Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts". Gene Ther
RRM3 (2,020 words) [view diff] exact match in snippet view article find links to article
Zakian, Virginia A. (2013-05-08). "Pif1 family helicases suppress genome instability at G-quadruplex motifs". Nature. 497 (7450): 458–462. doi:10.1038/nature12149
Spinocerebellar ataxia (2,733 words) [view diff] exact match in snippet view article find links to article
"On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability". J. Biol. Chem. 295 (13): 4134–4170. doi:10.1074/jbc.REV119.007678
Moscow Institute of Physics and Technology (3,659 words) [view diff] exact match in snippet view article find links to article
physicist who discovered multiphoton ionization. Yurij Ionov – discovered genome instability as a mechanism in colonic carcinogenesis Alexander Holevo – a mathematician
Aster yellows (1,642 words) [view diff] exact match in snippet view article find links to article
seen, they must be removed. Bai; et al. (May 2006). "Living with genome instability: the adaptation of phytoplasmas to diverse environments of their insect
Friedreich's ataxia (4,341 words) [view diff] exact match in snippet view article find links to article
(December 2016). "Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts". Gene Therapy
FANCD2 (2,483 words) [view diff] exact match in snippet view article find links to article
"Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability". Science. 351 (6275): 846–9. Bibcode:2016Sci...351..846L. doi:10
Fanconi anemia (3,283 words) [view diff] exact match in snippet view article find links to article
PMID 23149936. Deans AJ, West SC (December 2009). "FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia". Mol. Cell. 36 (6):
Bloom syndrome protein (2,581 words) [view diff] exact match in snippet view article find links to article
PMID 15364958. Deans AJ, West SC (24 December 2009). "FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia". Mol. Cell. 36 (6):
Trichothiodystrophy (1,032 words) [view diff] case mismatch in snippet view article find links to article
yexcr.2014.07.008. PMID 25016283. Edifizi D, Schumacher B (2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair
Epitalon (1,485 words) [view diff] exact match in snippet view article find links to article
Dzhokhadze, TA; Buadze, TZh; Rubanov, KD; Kiriia, NA; Lezhava, TA (2013). "Genome instability in pulmonary tuberculosis before and after treatment". Georgian Med
Nucleotide excision repair (3,599 words) [view diff] case mismatch in snippet view article find links to article
29018. PMC 4111694. PMID 24781187. Edifizi D, Schumacher B (2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair
Transposable element (6,646 words) [view diff] exact match in snippet view article find links to article
HH, Goodier JL (August 2002). "LINE drive. retrotransposition and genome instability". Cell. 110 (3): 277–80. doi:10.1016/S0092-8674(02)00868-1. PMID 12176313
Ribonuclease H (5,921 words) [view diff] exact match in snippet view article find links to article
biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability". Molecular Cell. 44 (6): 978–88. doi:10.1016/j.molcel.2011.10.017
Okazaki fragments (4,469 words) [view diff] exact match in snippet view article find links to article
endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability". Proceedings of the National Academy of Sciences of the United States
DNA damage theory of aging (10,063 words) [view diff] exact match in snippet view article find links to article
PMID 21600302. Burhans WC, Weinberger M (2007). "DNA replication stress, genome instability and aging". Nucleic Acids Research. 35 (22): 7545–7556. doi:10.1093/nar/gkm1059
Extrachromosomal DNA (5,090 words) [view diff] exact match in snippet view article find links to article
(spcDNAs), a type of eccDNA, are commonly found in conjunction with genome instability. SpcDNAs are derived from repetitive sequences such as satellite DNA
Triticale (5,017 words) [view diff] exact match in snippet view article find links to article
and rye genomes were noted to produce meiotic irregularities, and genome instability and incompatibility presented numerous problems when attempts were
Phytoplasma (5,153 words) [view diff] case mismatch in snippet view article find links to article
Shevchenko DV, Tsukerman K, Walunas T, et al. (2006). "Living with Genome Instability: the Adaptation of Phytoplasmas to Diverse Environments of Their Insect
Endoreduplication (3,091 words) [view diff] exact match in snippet view article find links to article
PMID 18981479. Storchova Z; Pellman D (2004). "From polyploidy to aneuploidy, genome instability and cancer". Nature Reviews Molecular Cell Biology. 5 (1): 45–54.
Chromosomal fragile site (2,366 words) [view diff] exact match in snippet view article find links to article
PMC 2144737. PMID 17679088. Aguilera, A; Gómez-González, B (Mar 2008). "Genome instability: a mechanistic view of its causes and consequences". Nature Reviews
DNA repair-deficiency disorder (3,785 words) [view diff] exact match in snippet view article find links to article
recovery shorter lifespan, earlier onset of aging related pathologies, genome instability ZMPSTE24 Homologous recombination lack of Zmpste24 prevents lamin
History of RNA biology (4,632 words) [view diff] exact match in snippet view article find links to article
inactivation. For example, piwi-interacting RNAs (piRNAs) prevent genome instability in germ line cells, while Xist (X-inactive-specific-transcript) is
FAN1 (1,862 words) [view diff] exact match in snippet view article find links to article
"Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability". Science. 351 (6275): 846–9. Bibcode:2016Sci...351..846L. doi:10
Chaperone-mediated autophagy (3,332 words) [view diff] exact match in snippet view article find links to article
stress. Conversely, decreased CMA activity associates with increased genome instability and decreased cell survival. CMA is involved in the removal of Chk1
Cancer/testis antigens (1,967 words) [view diff] exact match in snippet view article find links to article
activation of meiotic programs in cancer cells may contribute to the genome instability, and the meiosis-specific CT antigens might be involved in this process
Transcription-translation coupling (2,255 words) [view diff] exact match in snippet view article find links to article
E. & Nudler, E. (2011). "Linking RNA polymerase backtracking to genome instability in E. coli". Cell. 146 (4): 533–543. doi:10.1016/j.cell.2011.07.034
Ataxia–telangiectasia (10,236 words) [view diff] exact match in snippet view article find links to article
protein create a multisystem disorder? A–T has been described as a genome instability syndrome, a DNA repair disorder and a DNA damage response (DDR) syndrome
B. J. Rao (884 words) [view diff] exact match in snippet view article find links to article
professor and a chairperson. He is primarily interested in: Mechanisms Genome instability-Repairs & Spatial dynamics of Chromosomal Territories vis-à- vis Genome
Cancer syndrome (5,525 words) [view diff] exact match in snippet view article find links to article
implicated in maintaining and repairing DNA, which in turn leads to genome instability. Mutations in these genes allow further damage to DNA, which can lead
BLESS (1,968 words) [view diff] exact match in snippet view article find links to article
observed at high frequency during apoptosis and can contribute to genome instability, resulting in oncogenic mutations. For this reason, high-resolution
Origin of replication (12,929 words) [view diff] exact match in snippet view article find links to article
Barlow JH, Nussenzweig A (December 2014). "Replication initiation and genome instability: a crossroads for DNA and RNA synthesis". Cellular and Molecular Life
Mutation bias (3,001 words) [view diff] exact match in snippet view article find links to article
Kim and S. Jinks-Robertson (2012). "Transcription as a source of genome instability". Nat Rev Genet. 13 (3): 204–14. doi:10.1038/nrg3152. PMC 3376450
Condensin (7,338 words) [view diff] exact match in snippet view article find links to article
"Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability". Genes Dev. 30 (19): 2173–2186. doi:10.1101/gad.284562.116. PMC 5088566
POLD1 (8,503 words) [view diff] exact match in snippet view article find links to article
PMID 26578569. Lujan SA, Williams JS, Kunkel TA (2016-02-01). "Eukaryotic genome instability in light of asymmetric DNA replication". Critical Reviews in Biochemistry
ZTTK syndrome (2,931 words) [view diff] exact match in snippet view article find links to article
SON function causes insufficient production of downstream targets, genome instability and disrupted cell cycle progression which are fundamental to the
Kesara Margrét Anamthawat-Jónsson (2,647 words) [view diff] exact match in snippet view article find links to article
FISH was used in breast cancer research, for example, to detect genome instability related to BRCA2 and p53 mutations. Since 2010, Kesara has supervised