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searching for Genome instability 86 found (148 total)

SMC1A (2,088 words) [view diff] exact match in snippet view article find links to article

also takes part in DNA repair. The down-regulation of SMC1A causes genome instability, and CdLS cells carrying SMC1A variants display high level of chromosome

RMI1 (970 words) [view diff] exact match in snippet view article find links to article

RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene. Mutations in RMI1 are associated with Bloom-Syndrome

Stephen C. West (1,301 words) [view diff] exact match in snippet view article find links to article

DNA recombination and repair. He is known for pioneering studies on genome instability diseases including cancer. West obtained his BSc in 1974, and his

Jan Vijg (1,355 words) [view diff] exact match in snippet view article find links to article

the journal Aging published by Impact Journals (Albany, New York). Genome instability, i.e., the tendency of the genome to acquire mutations and epimutations

Ashok Venkitaraman (1,835 words) [view diff] exact match in snippet view article find links to article

biology of human cancer, particularly in elucidating the impact of genome instability on carcinogenesis and cancer therapy. He is best known for discovering

Inverted repeat (3,451 words) [view diff] exact match in snippet view article find links to article

pair with each other). These properties play an important role in genome instability and contribute not only to cellular evolution and genetic diversity

Infectious causes of cancer (5,214 words) [view diff] no match in snippet view article find links to article

Estimates place the worldwide risk of cancers from infectious causes at 16.1%. Viral infections are risk factors for cervical cancer, 80% of liver cancers

Breakage-fusion-bridge cycle (1,220 words) [view diff] exact match in snippet view article find links to article

type of malignant tumor. Although BFB cycles are a major source of genome instability, the rearrangement signature predicted by this model is not commonly

ZMPSTE24 (588 words) [view diff] exact match in snippet view article find links to article

PMID 21701264. Gonzalo S, Kreienkamp R (2015). "DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome". Curr. Opin. Cell Biol. 34:

RNASEH2B (885 words) [view diff] exact match in snippet view article find links to article

Ribonucleotides can be highly deleterious to the mammalian cell, causing genome instability, and that the RNASEH2 is a critical enzyme for ensuring the integrity

RecQ helicase (1,899 words) [view diff] exact match in snippet view article find links to article

PMC 5576896. PMID 27320928. Skouboe C, Bjergbaek L, Andersen AH (2005). "Genome instability as a cause of ageing and cancer: Implications of RecQ helicases".

Sirtuin 7 (1,531 words) [view diff] exact match in snippet view article find links to article

DSBs are one of the most significant types of DNA damage leading to genome instability. SIRT7 is recruited to DSBs where it specifically deacylates histone

Myung Kyungjae (989 words) [view diff] case mismatch in snippet view article find links to article

editor for Mutation Research, and been on the Editorial Board for Genome Instability and Disease, Genomics, Genome Integrity, and Molecular and Cellular

Simon Boulton (1,928 words) [view diff] exact match in snippet view article find links to article

has allowed Boulton to make seminal contributions to DNA repair, genome instability, and cancer. Among Boulton's achievements is the discovery that the

Mdm2 (4,010 words) [view diff] exact match in snippet view article find links to article

repair, chromosomal abnormalities, and genome instability. These data demonstrated Mdm2-induced genome instability can be mediated through Mdm2:Nbs1 interactions

Personalized onco-genomics (3,272 words) [view diff] exact match in snippet view article find links to article

Agency and is currently being led by Marco Marra and Janessa Laskin. Genome instability has been identified as one of the underlying hallmarks of cancer.

SETX (1,826 words) [view diff] exact match in snippet view article find links to article

of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability". DNA Repair. 19: 84–94. doi:10.1016/j.dnarep.2014.03.023. PMC 4051866

Bloom syndrome (2,752 words) [view diff] case mismatch in snippet view article find links to article

Hudson, Damien F.; et al. (15 December 2016). "Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome". PLOS Genet. 12 (12). e1006483.

Secreted frizzled-related protein 1 (6,321 words) [view diff] no match in snippet view article find links to article

Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene. Secreted frizzled-related protein

Nuclear envelope (2,035 words) [view diff] exact match in snippet view article find links to article

PMID 22567193. Lim; et al. (2016). "Nuclear envelope rupture drives genome instability in cancer". Molecular Biology of the Cell. 27 (21). MBoC: 3210–3213

Okazaki fragments (4,470 words) [view diff] exact match in snippet view article find links to article

Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability". Nature Communications (8): 15. doi:10.1038/ncomms15855. PMC 5490271

Titia de Lange (1,654 words) [view diff] exact match in snippet view article find links to article

illuminating how they protect chromosome ends and their role in genome instability in cancer by mapping the complex of molecules that loops the strands

Transcription factor II H (1,203 words) [view diff] case mismatch in snippet view article find links to article

PMID 14980221. S2CID 14312462. Edifizi D, Schumacher B (August 2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair

Breakthrough Prize in Life Sciences (354 words) [view diff] exact match in snippet view article find links to article

illuminating how they protect chromosome ends and their role in genome instability in cancer." Rockefeller University Napoleone Ferrara (b. 1956) Italy

Endonuclease (2,688 words) [view diff] exact match in snippet view article find links to article

endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability". Proceedings of the National Academy of Sciences of the United States

Hoyeraal–Hreidarsson syndrome (570 words) [view diff] exact match in snippet view article find links to article

deficiency causes Hoyeraal–Hreidarsson syndrome with short telomeres and genome instability". Human Molecular Genetics. 22 (16): 3239–49. doi:10.1093/hmg/ddt178

PLK4 (2,289 words) [view diff] exact match in snippet view article find links to article

Snyder M, Sluder G, Holland AJ (July 2015). "p53 protects against genome instability following centriole duplication failure". The Journal of Cell Biology

Recombination hotspot (1,398 words) [view diff] case mismatch in snippet view article find links to article

1042/BST0340526. PMID 16856851. Aguilera, A.; Gomez-Gonzalez, B. (2008). "Genome Instability: A Mechanistic View of Its Causes and Consequences". Nature Reviews

Gene duplication (3,683 words) [view diff] exact match in snippet view article find links to article

a whole genome duplication, there is a relatively short period of genome instability, extensive gene loss, elevated levels of nucleotide substitution and

Max Planck Institute for Biology of Ageing (986 words) [view diff] case mismatch in snippet view article find links to article

ADP-ribosylation in DNA repair and ageing (Ivan Matic / Research Group) Genome Instability and Ageing (Stephanie Panier / Max Planck Research Group) Metabolism

Ribonucleotide (2,619 words) [view diff] exact match in snippet view article find links to article

Lundström, EB; Johansson, E; Chabes, A; Kunkel, TA (October 2010). "Genome instability due to ribonucleotide incorporation into DNA". Nature Chemical Biology

Prelamin-A/C (2,525 words) [view diff] exact match in snippet view article find links to article

PMID 21701264. Gonzalo S, Kreienkamp R (June 2015). "DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome". Current Opinion in Cell

Frataxin (2,715 words) [view diff] exact match in snippet view article find links to article

(December 2016). "Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts". Gene Ther

Richard Kolodner (635 words) [view diff] exact match in snippet view article find links to article

recombination, DNA mismatch repair and the pathways that prevent genome instability. While studying DNA repair in bacteria and yeast, Kolodner identified

RRM3 (2,033 words) [view diff] exact match in snippet view article find links to article

Zakian, Virginia A. (2013-05-08). "Pif1 family helicases suppress genome instability at G-quadruplex motifs". Nature. 497 (7450): 458–462. Bibcode:2013Natur

Ribosome recycling factor (774 words) [view diff] exact match in snippet view article find links to article

cell nucleus. Loss of function of this gene leads to mitochondrial genome instability and respiratory incompetence. The crystal structure of RRF was first

FANCM (1,914 words) [view diff] exact match in snippet view article find links to article

PMID 18206976. Deans AJ, West SC (December 2009). "FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia". Molecular Cell. 36

Pseudouridine (2,895 words) [view diff] exact match in snippet view article find links to article

Unger, Ron; Michaeli, Shulamit; Späth, Gerald F. (21 December 2021). "Genome instability drives epistatic adaptation in the human pathogen Leishmania". Proceedings

Severe congenital neutropenia (2,387 words) [view diff] exact match in snippet view article find links to article

underlying molecular/genetic changes producing DNA mutations and genome instability, which contribute to initiation and progression of this disease.[citation

Spinocerebellar ataxia (3,004 words) [view diff] exact match in snippet view article find links to article

"On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability". The Journal of Biological Chemistry. 295 (13): 4134–4170. doi:10

FANCD2 (2,547 words) [view diff] exact match in snippet view article find links to article

"Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability". Science. 351 (6275): 846–9. Bibcode:2016Sci...351..846L. doi:10

Burkitt lymphoma (4,607 words) [view diff] exact match in snippet view article find links to article

has been shown to cause DNA damage, dysfunction of telomeres, and genome instability. Although the specific pathogenic mechanisms of EBV in Burkitt Lymphoma

Epitalon (1,511 words) [view diff] exact match in snippet view article find links to article

Dzhokhadze, TA; Buadze, TZh; Rubanov, KD; Kiriia, NA; Lezhava, TA (2013). "Genome instability in pulmonary tuberculosis before and after treatment". Georgian Med

Bloom syndrome protein (2,565 words) [view diff] exact match in snippet view article find links to article

PMID 15364958. Deans AJ, West SC (24 December 2009). "FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia". Mol. Cell. 36 (6):

Friedreich's ataxia (4,978 words) [view diff] exact match in snippet view article find links to article

(December 2016). "Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts". Gene Therapy

Aster yellows (1,644 words) [view diff] exact match in snippet view article find links to article

be removed.[citation needed] Bai; et al. (May 2006). "Living with genome instability: the adaptation of phytoplasmas to diverse environments of their insect

Nucleotide excision repair (3,623 words) [view diff] case mismatch in snippet view article find links to article

29018. PMC 4111694. PMID 24781187. Edifizi D, Schumacher B (2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair

Trichothiodystrophy (1,642 words) [view diff] case mismatch in snippet view article find links to article

yexcr.2014.07.008. PMID 25016283. Edifizi D, Schumacher B (2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair

Ribonuclease H (5,823 words) [view diff] exact match in snippet view article find links to article

biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability". Molecular Cell. 44 (6): 978–88. doi:10.1016/j.molcel.2011.10.017

Fanconi anemia (4,139 words) [view diff] exact match in snippet view article find links to article

PMID 35605178. Deans AJ, West SC (December 2009). "FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia". Mol. Cell. 36 (6):

Aicardi–Goutières syndrome (3,342 words) [view diff] exact match in snippet view article find links to article

Timothy I.; Russell, Helen R.; McKinnon, Peter J. (2021-12-15). "Genome instability independent of type I interferon signaling drives neuropathology caused

Transposable element (7,326 words) [view diff] exact match in snippet view article find links to article

HH, Goodier JL (August 2002). "LINE drive. retrotransposition and genome instability". Cell. 110 (3): 277–80. doi:10.1016/S0092-8674(02)00868-1. PMID 12176313

Extrachromosomal DNA (5,349 words) [view diff] exact match in snippet view article find links to article

(spcDNAs), a type of eccDNA, are commonly found in conjunction with genome instability. SpcDNAs are derived from repetitive sequences such as satellite DNA

Microbial cell factory (1,858 words) [view diff] exact match in snippet view article find links to article

strategy. For E.coli, studies have determined a strategy preventing genome instability to be the most robust metabolic engineering approach regardless of

DNA damage theory of aging (11,163 words) [view diff] exact match in snippet view article find links to article

PMID 21600302. Burhans WC, Weinberger M (2007). "DNA replication stress, genome instability and aging". Nucleic Acids Research. 35 (22): 7545–56. doi:10.1093/nar/gkm1059

Transient myeloproliferative disease (4,662 words) [view diff] exact match in snippet view article find links to article

various myeloid neoplasms. It is hypothesized that trisomy 21 induces genome instability and stress, contributing to the development of somatic mutations associated

Chromosomal fragile site (2,523 words) [view diff] exact match in snippet view article find links to article

PMC 2144737. PMID 17679088. Aguilera, A; Gómez-González, B (Mar 2008). "Genome instability: a mechanistic view of its causes and consequences". Nature Reviews

Leishmania (6,163 words) [view diff] exact match in snippet view article find links to article

Unger, Ron; Michaeli, Shulamit; Späth, Gerald F. (21 December 2021). "Genome instability drives epistatic adaptation in the human pathogen Leishmania". Proceedings

DNA repair-deficiency disorder (3,770 words) [view diff] exact match in snippet view article find links to article

recovery shorter lifespan, earlier onset of aging related pathologies, genome instability ZMPSTE24 Homologous recombination lack of Zmpste24 prevents lamin

Non B-DNA (796 words) [view diff] exact match in snippet view article find links to article

Hoogsteen base pairing and can cause mutations, rearrangements, and genome instability. H-DNA is thought to be involved in DNA replication, recombination

Endoreduplication (2,997 words) [view diff] exact match in snippet view article find links to article

PMID 16668285. Storchova Z, Pellman D (2004). "From polyploidy to aneuploidy, genome instability and cancer". Nature Reviews Molecular Cell Biology. 5 (1): 45–54.

Triticale (5,473 words) [view diff] exact match in snippet view article find links to article

and rye genomes were noted to produce meiotic irregularities, and genome instability and incompatibility presented numerous problems when attempts were

Helicase (6,744 words) [view diff] exact match in snippet view article find links to article

repair, recombination, replication, and transcription processes. Genome instability and early aging are conditions that arise from mutations in human

Trinucleotide repeat disorder (2,709 words) [view diff] exact match in snippet view article find links to article

"On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability". Journal of Biological Chemistry. 295 (13): 4134–4170. doi:10.1074/jbc

History of RNA biology (4,633 words) [view diff] exact match in snippet view article find links to article

inactivation. For example, piwi-interacting RNAs (piRNAs) prevent genome instability in germ line cells, while Xist (X-inactive-specific-transcript) is

Laura Niedernhofer (1,677 words) [view diff] case mismatch in snippet view article find links to article

Foundation for Medical Research. "AGE Presents Laura Niedernhofer - Genome Instability and Aging". YouTube. American Aging Association. May 24, 2021. "Healthy

Phytoplasma (5,422 words) [view diff] case mismatch in snippet view article find links to article

Shevchenko, DV; Tsukerman, K; Walunas, T; et al. (2006). "Living with Genome Instability: the Adaptation of Phytoplasmas to Diverse Environments of Their Insect

Chaperone-mediated autophagy (3,623 words) [view diff] exact match in snippet view article find links to article

stress. Conversely, decreased CMA activity associates with increased genome instability and decreased cell survival. CMA is involved in the removal of Chk1

Cancer/testis antigens (1,967 words) [view diff] exact match in snippet view article find links to article

activation of meiotic programs in cancer cells may contribute to the genome instability, and the meiosis-specific CT antigens might be involved in this process

Ataxia–telangiectasia (10,893 words) [view diff] exact match in snippet view article find links to article

protein creates a multisystem disorder A–T has been described as a genome instability syndrome, a DNA repair disorder, and a DNA damage response (DDR) syndrome

FAN1 (1,817 words) [view diff] exact match in snippet view article find links to article

"Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability". Science. 351 (6275): 846–9. Bibcode:2016Sci...351..846L. doi:10

B. J. Rao (916 words) [view diff] exact match in snippet view article find links to article

University of Hyderabad. He is primarily interested in: Mechanisms Genome instability-Repairs & Spatial dynamics of Chromosomal Territories vis-à- vis Genome

Transcription-translation coupling (2,238 words) [view diff] exact match in snippet view article find links to article

E. & Nudler, E. (2011). "Linking RNA polymerase backtracking to genome instability in E. coli". Cell. 146 (4): 533–543. doi:10.1016/j.cell.2011.07.034

Hereditary cancer syndrome (5,582 words) [view diff] exact match in snippet view article find links to article

implicated in maintaining and repairing DNA, which in turn leads to genome instability. Mutations in these genes allow further damage to DNA, which can lead

BLESS (1,978 words) [view diff] exact match in snippet view article find links to article

observed at high frequency during apoptosis and can contribute to genome instability, resulting in oncogenic mutations. For this reason, high-resolution

Origin of replication (12,563 words) [view diff] exact match in snippet view article find links to article

Barlow JH, Nussenzweig A (December 2014). "Replication initiation and genome instability: a crossroads for DNA and RNA synthesis". Cellular and Molecular Life

Henry Heng (1,665 words) [view diff] exact match in snippet view article find links to article

observed at the gene, epigenetic, and genome levels. Furthermore, genome instability can increase the ‘fuzziness’ of inheritance, which is useful for cellular

List of female Breakthrough Prize laureates (315 words) [view diff] exact match in snippet view article find links to article

illuminating how they protect chromosome ends and their role in genome instability in cancer." Rockefeller University Fundamental Physics (special) Fabiola

POLD1 (7,954 words) [view diff] exact match in snippet view article find links to article

PMID 26578569. Lujan SA, Williams JS, Kunkel TA (2016-02-01). "Eukaryotic genome instability in light of asymmetric DNA replication". Critical Reviews in Biochemistry

Mating of yeast (5,870 words) [view diff] case mismatch in snippet view article find links to article

Yeast Chromosome III Stability". In Muzi-Falconi M, Brown GW (eds.). Genome Instability. Methods in Molecular Biology. Vol. 1672. Springer Nature. pp. 1–9

Condensin (7,645 words) [view diff] exact match in snippet view article find links to article

"Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability". Genes Dev. 30 (19): 2173–86. doi:10.1101/gad.284562.116. PMC 5088566

Extrachromosomal circular DNA (4,050 words) [view diff] exact match in snippet view article find links to article

Robberson DL, Barrera-Saldaña HA, Lambrou TP, Saunders GF (March 1982). "Genome instability in a region of human DNA enriched in Alu repeat sequences". Nature

Olduvai domain (4,550 words) [view diff] exact match in snippet view article find links to article

region, which is known to be a duplication-rich hotspot of human genome instability and evolution. The first Olduvai triplet of each NBPF gene in humans

ZTTK syndrome (2,954 words) [view diff] exact match in snippet view article find links to article

SON function causes insufficient production of downstream targets, genome instability and disrupted cell cycle progression which are fundamental to the

Mutation bias (3,377 words) [view diff] exact match in snippet view article find links to article

Kim and S. Jinks-Robertson (2012). "Transcription as a source of genome instability". Nat Rev Genet. 13 (3): 204–14. doi:10.1038/nrg3152. PMC 3376450

Kesara Margrét Anamthawat-Jónsson (2,651 words) [view diff] exact match in snippet view article find links to article

FISH was used in breast cancer research, for example, to detect genome instability related to BRCA2 and p53 mutations. Since 2010, Kesara has supervised