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Longer titles found: Conditional gene knockout (view)

searching for Gene knockout 106 found (240 total)

Virotherapy (3,501 words) [view diff] exact match in snippet view article find links to article

use three different types of treatment methods: gene overexpression, gene knockout, and suicide gene delivery. Gene overexpression adds genetic sequences

Estrogen-related receptor (1,175 words) [view diff] exact match in snippet view article find links to article

elucidated through the generation of sophisticated tissue-specific gene knockout mouse models.[citation needed] Schreiber SN, Emter R, Hock MB, Knutti

Formyl peptide receptor 2 (4,314 words) [view diff] exact match in snippet view article find links to article

difficult to extrapolate human FPR functions based on genetic (e.g. gene knockout or forced overexpression) or other experimental manipulations of the

Cdx (946 words) [view diff] exact match in snippet view article find links to article

and blastocyst implantation if the knockout was in both alleles. Cdx2 gene knockout would also result in multiple polyps in the midgut which are related

Jun dimerization protein (4,154 words) [view diff] exact match in snippet view article find links to article

JDP2 has INHAT activity and inhibits histone methylation in vitro. Gene knockout mice have a shorter tail, are smaller, have low neutrophil count. and

Complexin (1,126 words) [view diff] exact match in snippet view article find links to article

increase neurotransmitter release by 60–70% as demonstrated by complexin gene knockout in mice. A number of human neurological diseases have been linked to

KHDRBS1 (2,812 words) [view diff] no match in snippet view article find links to article

KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene. This gene encodes

Lysine riboswitch (756 words) [view diff] exact match in snippet view article find links to article

comparison to various expensive and difficult methods such as utilizing a gene knockout. With lysine as an intracellular signal, the riboswitch regulates gene

RNASEH2B (885 words) [view diff] exact match in snippet view article find links to article

gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). RNASEH2B gene knockout in mice, leads to early embryonic lethality, hence genetically engineered

Detoxification (1,127 words) [view diff] no match in snippet view article find links to article

Levels of Enzymes Involved in Drug Metabolism between Transgenic or Gene-knockout and the Parental Mice". Tpx.sagepub.com. January 1, 2001. Retrieved

ALPL (2,063 words) [view diff] exact match in snippet view article find links to article

pyrophosphate. Mice that lack a functional form of this enzyme (gene knockout mice) show abnormal skeletal and dental development including a mineralization

Richard Shine (2,215 words) [view diff] exact match in snippet view article find links to article

ability to metamorphose to the terrestrial stage has been blocked by gene knockout. By consuming newly-laid eggs, the “Peter Pan” (non-metamorphosing)

William S. Sly (913 words) [view diff] exact match in snippet view article find links to article

identification of the product it encodes. He also showed that the HFE gene knockout in the mouse produces iron storage resembling human hemochromatosis

GBX2 (1,472 words) [view diff] exact match in snippet view article find links to article

motor nerve V and many other derivatives of rhombomeres 1-3. GBX2 gene knockout embryos will continue to develop and will reach full term pregnancy

UCP3 (1,932 words) [view diff] exact match in snippet view article find links to article

DM, Lowell BB (May 2000). "Energy metabolism in uncoupling protein 3 gene knockout mice". The Journal of Biological Chemistry. 275 (21): 16258–66. doi:10

Karen Avraham (936 words) [view diff] exact match in snippet view article find links to article

Positional-Candidate Cloning of Genes from Mouse Mutants, Karen B. Avraham, Gene knockout protocols, Martin J. Tymms; Ismail Kola (eds.). John M. Walker (series

Susumu Tonegawa (1,605 words) [view diff] no match in snippet view article find links to article

ensuing years. Tonegawa's lab pioneered introductory transgenic and gene-knockout technologies in mammalian systems. He was involved in early work demonstrating

Enzyme promiscuity (3,442 words) [view diff] exact match in snippet view article find links to article

Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection". Molecular Systems Biology. 2: 2006.0008

Phenotype (3,335 words) [view diff] exact match in snippet view article find links to article

(January 2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection". Molecular Systems Biology. 2 (1): 2006

Centromere protein E (1,069 words) [view diff] exact match in snippet view article find links to article

centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype". Curr. Biol. 10 (21): 1319–28. Bibcode:2000CBio...10.1319U

EUCOMM (635 words) [view diff] no match in snippet view article find links to article

resource, and it allows a more nuanced study of the effects of the gene-knockout. The purpose of this library is to enable the mouse research community

Sarcocystis neurona (1,642 words) [view diff] exact match in snippet view article find links to article

possibly other neural cells. Studies in immune deficient, interferon gamma gene knockout (KO) mice fed S. neurona sporocysts, indicate the Sarcocystis neurona

Formyl peptide receptor 3 (2,259 words) [view diff] exact match in snippet view article find links to article

difficult to extrapolate human FPR functions based on genetic (e.g. gene knockout or forced overexpression) or other experimental manipulations of the

CENPA (1,927 words) [view diff] exact match in snippet view article find links to article

centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype". Current Biology. 10 (21): 1319–1328. Bibcode:2000CBio..

Synthetic rescue (627 words) [view diff] exact match in snippet view article find links to article

strongest form of synthetic rescues, in which the deleterious impact of a gene knockout is mitigated by an additional genetic perturbation that is also deleterious

Allergic conjunctivitis (2,280 words) [view diff] exact match in snippet view article find links to article

and plants, have also shown mitigative effects in animal models of gene knockout mice. Allergic conjunctivitis occurs more frequently among those with

FGF4 (2,075 words) [view diff] exact match in snippet view article find links to article

molecule that is involved in many important processes. Studies using Fgf4 gene knockout mice showed developmental defects in embryos both in vivo and in vitro

50S ribosomal protein L25 (372 words) [view diff] exact match in snippet view article find links to article

Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection". Molecular Systems Biology. 2: 2006.0008

TBX5 (gene) (2,467 words) [view diff] no match in snippet view article

hindlimbs with thicker bones, more similar to their frontlimb wings. A gene "knockout" model for TBX5 by CRISPR/Cas9 genome editing has been created. This

Attenuated vaccine (4,224 words) [view diff] exact match in snippet view article find links to article

typically attenuated by passage, similar to the method used in viruses. Gene knockout guided by reverse genetics is also used. Attenuated vaccines can be

Acid-sensing ion channel (2,777 words) [view diff] exact match in snippet view article find links to article

creates signaling pathways for apoptosis and necrosis in the cell. Gene knockout studies as well as ASIC blockades have shown to reduce brain infarct

Biopterin (752 words) [view diff] exact match in snippet view article find links to article

one defective gene copy is required for the condition to occur. Mouse gene knockout models that block biopterin synthesis completely die shortly after birth

MAP1B (1,060 words) [view diff] exact match in snippet view article find links to article

processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested

DHHC domain (2,105 words) [view diff] exact match in snippet view article find links to article

colleagues speculate is involved in the pathology of Huntington's disease. A gene knockout experiment of the mouse homologue of ZDHHC13 showed hair loss, severe

Secretin (3,526 words) [view diff] exact match in snippet view article find links to article

of angiotensin II. In the absence of secretin or its receptor in the gene knockout animals, central injection of angiotensin II was unable to stimulate

Mycobacterium smegmatis (2,153 words) [view diff] exact match in snippet view article find links to article

smegmatis and testing efficiency of ESX secretion before and after gene knockout, specific genes can be identified as necessary for ESX secretion. These

Autoimmune regulator (3,095 words) [view diff] exact match in snippet view article find links to article

primary adrenocortical failure and chronic mucocutaneous candidiasis. A gene knockout of the murine homolog of Aire has created a transgenic mouse model that

Root (5,898 words) [view diff] exact match in snippet view article find links to article

et al. used wild type plants along with varying protein knockout and gene knockout Arabidopsis mutants to observe the results these mutations had on the

MAP3K1 (3,167 words) [view diff] exact match in snippet view article find links to article

strain causes the same open-eyelids-at-birth mutational phenotype as the gene knockout mutations of the mouse (but not human) MAP3K1 homolog (Map3k1) and also

Plasmid (5,666 words) [view diff] exact match in snippet view article find links to article

chromosome, utilizing a plasmid vector, which allows for studies in gene knockout experiments. By using plasmids for the uptake of BGCs, microorganisms

Anopheles (4,120 words) [view diff] exact match in snippet view article find links to article

Simões ML, Marois E, Dimopoulos G (2018-03-08). "CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection". PLOS

Clostridioides difficile toxin A (2,759 words) [view diff] exact match in snippet view article find links to article

the role of both toxins in pathogenesis of C. difficile infection, a gene knockout system in a hamster infection model was developed. By permanently knocking

Karl Deisseroth (2,888 words) [view diff] exact match in snippet view article find links to article

Joe Z. Tsien; et al. (1996). "Subregion- and cell type-restricted gene knockout in mouse brain". Cell. 87 (7): 1317–1326. doi:10.1016/S0092-8674(00)81826-7

Mate choice copying (2,671 words) [view diff] no match in snippet view article find links to article

copying as OT gene-knockout female mice have failed to recognize the demonstrator female and the target male. Moreover, the OT gene-knockout mice have showed

Genetics of obesity (2,298 words) [view diff] case mismatch in snippet view article find links to article

MacDougald, Ormond A.; Koenig, Ronald J.; Xu, Bin (May 2014). "SRA Gene Knockout Protects against Diet-induced Obesity and Improves Glucose Tolerance"

TMPRSS2 (2,578 words) [view diff] exact match in snippet view article find links to article

cascades necessary for normal physiological function of the prostate. Gene knockout mice lacking TMPRSS2 show no abnormalities. As a type II transmembrane

Transcription activator-like effector nuclease (3,148 words) [view diff] exact match in snippet view article find links to article

"Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes". Nucleic Acids Research. 39 (14):

Michael Tordoff (650 words) [view diff] exact match in snippet view article find links to article

; Tordoff, M. G. (2008). "Reduced body weight is a common effect of gene knockout". BMC Genetics. 9: 4. doi:10.1186/1471-2156-9-4. PMC 2263071. PMID 18182103

Cowpox (4,292 words) [view diff] exact match in snippet view article find links to article

Osterrieder N, Tischer BK (January 2014). "Generation of a complete single-gene knockout bacterial artificial chromosome library of cowpox virus and identification

Bulimia nervosa (8,699 words) [view diff] exact match in snippet view article find links to article

of appetite is also seen in women with bulimia nervosa. In addition, gene knockout studies in mice have shown that mice that have the gene encoding estrogen

List of unusual biological names (796 words) [view diff] exact match in snippet view article find links to article

CRISPy TAKO (CRISPR Turbo Accelerated KnockOut) ("crispy taco") is a gene knockout technique useful for in vivo reverse genetic screens. List of chemical

Chimera (genetics) (6,610 words) [view diff] case mismatch in snippet view article

"Aggregation Chimeras: Combining ES Cells, Diploid and Tetraploid Embryos". Gene Knockout Protocols. Methods in Molecular Biology. Vol. 158. pp. 135–54. doi:10

Senolytic (2,028 words) [view diff] case mismatch in snippet view article find links to article

β-galactosidase (a common senescence marker) Yes BIRC5 knockout Crispr/Cas9 BIRC5 Gene Knockout. Crispr/Cas9 is used to trigger apoptosis in relation to a specified

Thermotoga maritima (1,971 words) [view diff] exact match in snippet view article find links to article

heterologous gene expression in E. coli or predicting models since a gene knockout mutant of T. maritima remained unavailable. Developing a genetic system

Ibrokhim Abdurakhmonov (1,367 words) [view diff] no match in snippet view article find links to article

cotton genomics. The result of these studies was the development of gene-knockout technology for obtaining high-quality, long-staple, high-yielding and

Gene (12,541 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection". Molecular Systems Biology. 2: 2006.0008

DNA damage-inducible transcript 3 (5,471 words) [view diff] exact match in snippet view article find links to article

against diet induced metabolic syndromes in mice. Mice with germline Chop gene knockout have better glycemic control despite unchanged obesity. A plausible

KLRG1 (1,599 words) [view diff] exact match in snippet view article find links to article

Unlike the obvious enhanced immune activation present in CTLA-4 and PD-1 gene knockout mice, KLRG1 knockout mice initially were found to have no abnormal features

Macrophage (10,131 words) [view diff] exact match in snippet view article find links to article

homeostatic control by sympathetic innervation, experiments using ADRB2 gene knockout mice indicate that this effect is indirectly exerted through the modulation

Genetic ablation (1,066 words) [view diff] exact match in snippet view article find links to article

a homozygous colony can be created through breeding. In 1990, the gene knockout technique was just developing. There was a lack of information on the

RELA (6,507 words) [view diff] exact match in snippet view article find links to article

RFC1, RNF25, SIRT1, SOCS1, SP1, STAT3, TAF4B, TBP, TP53, and TRIB3. Gene knockout of NF-κB genes via homologous recombination in mice showed the role

Wall stress relaxation (992 words) [view diff] exact match in snippet view article find links to article

as plant pathogenic bacteria, identified by phylogenetic analysis. Gene knockout experiments were used in discovering that bacterial expansins facilitate

Initiation-specific alpha-1,6-mannosyltransferase (537 words) [view diff] exact match in snippet view article find links to article

och1+ gene encoding alpha-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation"

Basic helix-loop-helix ARNT-like protein 1 (5,804 words) [view diff] exact match in snippet view article find links to article

such as preterm labor, low birth weight, and gestational diabetes. Gene knockout models in mice have helped to understand the role Bmal1 has in transcriptional

Tropomyosin (6,192 words) [view diff] exact match in snippet view article find links to article

embryonic stem cells and preimplantation mouse embryos. Results from gene knockout experiments can be ambiguous and must be carefully examined. In studies

Transcription activator-like effector (2,796 words) [view diff] exact match in snippet view article find links to article

"Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes". Nucleic Acids Research. 39 (14):

Testosterone and the cardiovascular system (1,576 words) [view diff] exact match in snippet view article find links to article

rabbits fed high cholesterol diets and mice with low-density lipoprotein gene knockout. Fatty deposition within the aorta associated with low endogenous testosterone

Toll-like receptor (6,771 words) [view diff] exact match in snippet view article find links to article

specificity has now been established by gene targeting (also known as "gene knockout"): a technique by which individual genes may be selectively deleted

Testin (1,128 words) [view diff] exact match in snippet view article find links to article

correctly organise their focal adhesions and actin stress fibres. In gene knockout experiments, transgenic mice lacking both copies of the TES gene displayed

Fetuin (1,090 words) [view diff] exact match in snippet view article find links to article

kininogen (KNG). The function of Fetuin-A in the body was determined by gene knockout technology in mice. Knocking out the gene for fetuin-A rendered the

PTPN1 (2,731 words) [view diff] exact match in snippet view article find links to article

implications in the treatment of type 2 diabetes as well as cancer. Gene knockout studies conducted in murine models has provided substantial evidence

Leukotriene B4 receptor 2 (6,698 words) [view diff] exact match in snippet view article find links to article

to diseases such as ulcerative colitis and Crohn's disease. LTB4R1 gene knockout provides complete protection from the joint inflammation occurring in

Robustness (evolution) (4,629 words) [view diff] exact match in snippet view article

H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection". Molecular Systems Biology. 2 (1): 2006

Aldehyde dehydrogenase 3 family, member A1 (2,547 words) [view diff] no match in snippet view article find links to article

clarification of ALDH3A1's role in the cornea has been provided by gene-knockout studies in which genes encoding ALDH3A1 were removed from the mice genome

Perlecan (11,012 words) [view diff] exact match in snippet view article find links to article

importance of perlecan to mammalian development is demonstrated by perlecan gene knockout experiments. Nearly half of all mice in which the perlecan gene has

DNA adenine methylase (1,844 words) [view diff] exact match in snippet view article find links to article

leaves the bacteria viable. The retainment of viability despite a dam gene knockout is also seen in Salmonella and Aggregatibacter actinomycetemcomitans

Lipid signaling (5,633 words) [view diff] no match in snippet view article find links to article

Langerhans. Inhibition of ceramide synthesis in mice via drug treatments or gene-knockout techniques prevented insulin resistance induced by fatty acids, glucocorticoids

Animal psychopathology (7,479 words) [view diff] exact match in snippet view article find links to article

development of compulsive behavior in mice. Male mice with an aromatase gene knockout who were unable to produce estrogen showed excessive grooming and wheel

Essential gene (8,521 words) [view diff] exact match in snippet view article find links to article

were essential although the selected genes were not representative. Gene knockout experiments are not possible or at least not ethical in humans. However

Site-specific recombinase technology (3,200 words) [view diff] exact match in snippet view article find links to article

excision of loxP-flanked ("floxed") genes leading to cell-specific gene knockout of such a floxed gene after Cre becomes expressed in the tissue of interest

CRABP2 (1,653 words) [view diff] exact match in snippet view article find links to article

which may cause defects in the development of those tissues. CRABP2 gene knockout studies should be performed to determine any specific defects caused

Carnitine O-octanoyltransferase (1,421 words) [view diff] exact match in snippet view article find links to article

transfer from acetylcarnitine to coenzyme A. Rescue experiments with CROT gene knockout cells have shown that peroxisomal CROT can mediate acetyl-CoA production

Karen Koch (plant biologist) (793 words) [view diff] exact match in snippet view article

development, cell-wall composition, and mechanisms of sugar transfer. Single-gene knockout mutants are being used to examine gene function. Current[when?] projects

Actin (18,282 words) [view diff] exact match in snippet view article find links to article

shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice". PLOS Genetics. 2 (1): e10. doi:10.1371/journal.pgen.0020010

Microbial cell factory (1,858 words) [view diff] exact match in snippet view article find links to article

"Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes". Nucleic Acids Research. 39 (14):

Recombinant AAV mediated genome engineering (2,673 words) [view diff] exact match in snippet view article find links to article

Civin CI, Bunz F (2005). "Improved methods for the generation of human gene knockout and knockin cell lines". Nucleic Acids Res. 33 (18): e158. doi:10.1093/nar/gni160

Cre-Lox recombination (5,058 words) [view diff] exact match in snippet view article find links to article

Anderson DJ, et al. (December 1996). "Subregion- and cell type-restricted gene knockout in mouse brain". Cell. 87 (7): 1317–26. doi:10.1016/s0092-8674(00)81826-7

TSHZ1 (1,470 words) [view diff] exact match in snippet view article find links to article

development and craniofacial morphogenesis. Experiments involving whole gene knockout of Tshz1 during development resulted in universal lethality of M. musculus

Science and technology in Uzbekistan (3,453 words) [view diff] exact match in snippet view article find links to article

of the year’ by the International Cotton Advisory Committee for a ‘gene knockout technology’’ he had developed with biologists from the Texas A&M University

Mike Berridge (1,599 words) [view diff] no match in snippet view article find links to article

and Berridge MV. Cell surface oxygen consumption by mitochondrial gene-knockout cells. Biochem Biophys Acta, 1656: 79-87 (2004). doi:10.1016/j.bbabio

Rhonda Voskuhl (1,468 words) [view diff] exact match in snippet view article find links to article

responsible for the reduction of clinical EAE symptoms in mice. Using a gene knockout system Cre-Lox, the research team was able to remove ERα from neurons

Optogenetics (11,917 words) [view diff] exact match in snippet view article find links to article

Anderson DJ, et al. (December 1996). "Subregion- and cell type-restricted gene knockout in mouse brain". Cell. 87 (7): 1317–1326. doi:10.1016/S0092-8674(00)81826-7

Barred owl (22,180 words) [view diff] case mismatch in snippet view article find links to article

from a Barred Owl (Strix varia) Definitive Host and Interferon Gamma Gene Knockout Mice as Experimental Intermediate Host". Journal of Parasitology. 103

Calponin 2 (2,182 words) [view diff] exact match in snippet view article find links to article

found in blood cells of myeloid lineage. Monocytes derived from Cnn2 gene knockout mice proliferated faster than wild type control cells. Calponin 2-null

Giovanna Mallucci (2,009 words) [view diff] exact match in snippet view article find links to article

diseases Institutions University of Cambridge University of Leicester Thesis Prion protein gene knockout in the mouse using the Cre/1oxP system (2001)

Makoto Furutani-Seiki (1,372 words) [view diff] exact match in snippet view article find links to article

Yamazoe, Mitsuyoshi; Hidaka, Masayuki (2006-12-08). "Generation of medaka gene knockout models by target-selected mutagenesis". Genome Biology. 7 (12): R116

Joe Z. Tsien (2,946 words) [view diff] exact match in snippet view article find links to article

Joe Z. Tsien; et al. (1996). "Subregion- and cell type-restricted gene knockout in mouse brain". Cell. 87 (7): 1317–1326. doi:10.1016/S0092-8674(00)81826-7

Flux balance analysis (6,061 words) [view diff] exact match in snippet view article find links to article

improve the prediction of the metabolic state of an organism after a gene knockout. It follows the same premise as MOMA that an organism would try to restore

Cortical thymic epithelial cells (2,881 words) [view diff] no match in snippet view article find links to article

which is defined by the presence of β5t subunit encoded by Psmb11 gene. Knockout of this gene revealed only slight reduction in positive selection of

Transposon sequencing (1,748 words) [view diff] exact match in snippet view article find links to article

types of study are dependent on preexisting genomic microarrays or gene knockout arrays, whereas Tn-seq is not. Tn-seq's utilization of massively parallel

Min Zhuo (2,503 words) [view diff] exact match in snippet view article find links to article

being a key enzyme for triggering injury-related LTP in the ACC. Using gene knockout mice lacking AC1, he discovered that AC1 is critical for ACC LTP (including

Branched chain amino acid exporter family (1,286 words) [view diff] exact match in snippet view article find links to article

production of l -valine based on transcriptome analysis and in silico gene knockout simulation". Proceedings of the National Academy of Sciences. 104 (19):

Wei Yan (biologist) (3,220 words) [view diff] exact match in snippet view article

contraction in gamete/embryo transport. Additionally, using a variety of gene knockout/genome editing technologies, his lab discovered many genetic networks

Enterobacterial common antigen (1,836 words) [view diff] no match in snippet view article find links to article

reduction in O-chain synthesis while maintaining ECA stability. Several gene-knockout experiments show that upon altering genes participating in the synthesis

Genome-wide CRISPR-Cas9 knockout screens (6,172 words) [view diff] exact match in snippet view article find links to article

library (Addgene #1000000069) generated by the Moffat lab. Targeted gene knockout using CRISPR/Cas9 requires the use of a delivery system to introduce

Thermal shift assay (5,885 words) [view diff] exact match in snippet view article find links to article

conditions The biochemical function of protein targets identified through gene knockout or proteomics approaches are often obscure if they have low amino acid