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searching for Genetic ablation 34 found (39 total)

Ablation (2,942 words) [view diff] exact match in snippet view article find links to article

ablation is the removal of a biological structure or functionality. Genetic ablation is another term for gene silencing, in which gene expression is abolished

PTPN1 (2,731 words) [view diff] exact match in snippet view article find links to article

phosphotyrosine residues of the activated insulin receptor kinase. In mice, genetic ablation of PTPN1 results in enhanced insulin sensitivity. Several other tyrosine

Insulin-like growth factor 2 (1,932 words) [view diff] exact match in snippet view article find links to article

This activity resides within the first 16 amino acids of preptin. Genetic ablation of the preptin-coding region of Igf2 in female mice impairs pancreatic

Gastric inhibitory polypeptide (1,052 words) [view diff] exact match in snippet view article find links to article

remodeling. Researchers at Universities of Angers and Ulster evidenced that genetic ablation of the GIP receptor in mice resulted in profound alterations of bone

Class III PI 3-kinase (511 words) [view diff] exact match in snippet view article find links to article

FYVE domain overexpression also disrupts mTOR signaling. However, genetic ablation of Vps34 in Drosophila does not affect dTORC1 signaling. Thus, the

Bulboid corpuscle (460 words) [view diff] exact match in snippet view article find links to article

Krause corpuscle afferent terminals evoked penile erection, while genetic ablation of Krause corpuscles impaired intromission and ejaculation of males

PTPRD (1,325 words) [view diff] exact match in snippet view article find links to article

However, PTPRD has been identified as the neural receptor for asprosin. Genetic ablation of PTPRD results in extreme leanness and loss of appetite. More specifically

Nidogen (584 words) [view diff] exact match in snippet view article find links to article

Miosge N, Baranowsky A, Mokkapati S, et al. (August 2005). "Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality

Hypoblast (1,626 words) [view diff] exact match in snippet view article find links to article

Sanchez R., Rodriguez-Manzaneque M. T., Bosl M. R., et al. (2008). Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral

Adenylate kinase (2,459 words) [view diff] exact match in snippet view article find links to article

individuals with an AK2 deficiency will have sensorineural deafness. AK1 genetic ablation decreases tolerance to metabolic stress. AK1 deficiency induces fiber-type

Dendrotoxin (1,659 words) [view diff] exact match in snippet view article find links to article

M.; Trosclair, Krystle; Hamilton, KA; Glasscock, E (2018-11-13). "Genetic ablation or pharmacological inhibition of Kv1.1 potassium channel subunits impairs

ETHE1 (1,152 words) [view diff] exact match in snippet view article find links to article

ETHE1 and affinity for the ETHE1 substrate. Mouse models of Ethe1 genetic ablation likewise exhibited reduced sulfide dioxygenase catabolism and cranial

Catherina Becker (1,136 words) [view diff] exact match in snippet view article find links to article

"Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish". Development. 143 (9): 577–95. doi:10.1242/dev

Mitochondrial permeability transition pore (3,440 words) [view diff] exact match in snippet view article find links to article

formed by the inner membrane Adenine Nucleotide Translocase (ANT), but genetic ablation of such protein still led to MPT onset. Thus, the only MPTP components

CAMKK2 (1,817 words) [view diff] exact match in snippet view article find links to article

homeostasis by forming a signaling complex with AMPKα/β and Ca2+/CaM. Genetic ablation of CaMKK2 decreases AMPK activity in hypothalamus and down regulates

Olivocochlear system (4,565 words) [view diff] exact match in snippet view article find links to article

onset of hearing, auditory sensitivity is compromised. However, upon genetic ablation of either the alpha9 or alpha10 genes, such effects are not observed

Phosphatidylinositol 5-phosphate (2,323 words) [view diff] exact match in snippet view article find links to article

dephosphorylation of PtdIns(3,5)P2 by overexpressed myotubularin 1. Concordantly, genetic ablation of the myotubularin-related protein 2 (MTMR2) causes elevation of cellular

Shelterin (2,334 words) [view diff] exact match in snippet view article find links to article

in humans and mice, because of the stem-cell quality of the cancer. Genetic ablation and chemical inhibition of TRF1 in mouse models of the brain cancer

Jacques Pouysségur (1,388 words) [view diff] exact match in snippet view article find links to article

metabolism », J Biol Chem., (2018) 293, p. 15947-15961 Dayer B., et al., « Genetic ablation of the cystine transporter xCT in pancreatic cancer cells inhibits

MALT1 (2,753 words) [view diff] exact match in snippet view article find links to article

in humans is encoded by the MALT1 gene. It's the human paracaspase. Genetic ablation of the paracaspase gene in mice and biochemical studies have shown

Rett syndrome (6,112 words) [view diff] exact match in snippet view article find links to article

pathway is causative from Parkinson disease (PD) in humans. Toxic and/or genetic ablation of SNpc neurons produces experimental parkinsonism in mice and primates

Pierre Léopold (1,086 words) [view diff] exact match in snippet view article find links to article

hormonal mechanism predicted 30 years earlier allowing damaged tissues (genetic ablation or tumor growth) to act on the growth of other organs and to control

Asprosin (2,349 words) [view diff] exact match in snippet view article find links to article

through binding to protein tyrosine phosphatase receptor delta (PTPRD). Genetic ablation of PTPRD results in extreme leanness and loss of appetite. More specifically

Astrocyte (9,353 words) [view diff] exact match in snippet view article find links to article

role in axon regeneration. However, recently, it was found through genetic ablation studies that astrocytes are actually required for regeneration to occur

Jeffrey Flier (3,560 words) [view diff] exact match in snippet view article find links to article

Flier, JS (1993). "Development of obesity in transgenic mice after genetic ablation of brown adipose tissue". Nature. 366 (6457): 740–2. Bibcode:1993Natur

De'Broski R. Herbert (2,323 words) [view diff] exact match in snippet view article find links to article

led by Carla Rothlin at Yale that aimed to determine the role that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional

MicroRNA (16,818 words) [view diff] exact match in snippet view article find links to article

Smith P, Galas MC, Planel E, Silahtaroglu AN, et al. (October 2010). "Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation

CSRP3 (4,114 words) [view diff] exact match in snippet view article find links to article

failure, independently of mutations. Studies in Drosophila revealed that genetic ablation of Mlp84B, the Drosophila homolog of MLP, was associated with pupal

Ali J. Marian (1,575 words) [view diff] exact match in snippet view article find links to article

124(6), 856–873. Cheedipudi, S. M., Asghar, S., & Marian, A. J. (2022). Genetic ablation of the DNA damage response pathway attenuates lamin-associated dilated

George Michalopoulos (2,734 words) [view diff] exact match in snippet view article find links to article

liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase". Hepatology. 50 (3): 844–851. doi:10.1002/hep

Ana Domingos (2,568 words) [view diff] exact match in snippet view article find links to article

Bernardes, Ana I Domingos. A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Commun. 2017 Apr 3;8:14967. Andreia

Biological functions of nitric oxide (7,668 words) [view diff] exact match in snippet view article find links to article

Gu Q, Yang X, Lin L, Li S, Li Q, Zhong S, et al. (December 2014). "Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish

Male contraceptive (15,377 words) [view diff] case mismatch in snippet view article find links to article

PMC 7401355. PMID 32588885. Numata S, McDermott JP, Blanco G (2022). "Genetic Ablation of Na,K-ATPase α4 Results in Sperm Energetic Defects". Frontiers in

Jacob Hanna (5,656 words) [view diff] exact match in snippet view article find links to article

optimize naive conditions in humans since only naive cells can tolerate genetic ablation or RNA and DNA methylation (deposited and maintained by METTL3 and