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searching for LRRK2 20 found (46 total)

alternate case: lRRK2

Valina L. Dawson (3,384 words) [view diff] exact match in snippet view article find links to article

LRRK2 increase its kinase activity and that inhibition of LRRK2 kinase activity is protective in models of Parkinson’s disease. The increase in LRRK2
Ted M. Dawson (2,720 words) [view diff] exact match in snippet view article find links to article
that inhibiting LRRK2 kinase activity is protective. In collaborative studies, they identified Rab35 as the key Rab linked to LRRK2 neurotoxicity. Their
Anne Wojcicki (1,523 words) [view diff] exact match in snippet view article find links to article
leucine-rich repeat kinase 2 (LRRK2) receptor inhibitor, which could provide major benefits to Parkinson's treatments, as the LRRK2 gene is an aspect of the
Expedition 53 (1,824 words) [view diff] exact match in snippet view article find links to article
microgravity, the CASIS PCG7 study, which grew larger versions of the protein LRRK2 to help study Parkinson's disease, and mice from the Rodent Research-9 study
Vernalis Research (1,143 words) [view diff] exact match in snippet view article find links to article
Chen IJ, et al. (November 2017). "Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase
Rab (G-protein) (1,315 words) [view diff] exact match in snippet view article
endoplasmic reticulum RAB25 small-scale transport, promoter for tumor development RAB29 recruits LRRK2 to TGN RAB39A binds Caspase-1 in inflammasome
Phosphomimetics (642 words) [view diff] exact match in snippet view article find links to article
Valina L Dawson (2014). "Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease". Cell. 157 (2): 472–485. doi:10
LRRK1 (578 words) [view diff] exact match in snippet view article find links to article
PMID 17353931. Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent
Diapocynin (164 words) [view diff] exact match in snippet view article find links to article
early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse". Neuroscience Letters. 549: 57–62. doi:10.1016/j
Sonia Gandhi (scientist) (860 words) [view diff] exact match in snippet view article
at the Francis Crick Institute. Gandhi's publications include: A common LRRK2 mutation in idiopathic Parkinson's disease Mechanism of Oxidative Stress
CKMT1A (962 words) [view diff] exact match in snippet view article find links to article
Yue Z, Xu Z (October 2011). "Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture
Protein targeting (3,000 words) [view diff] exact match in snippet view article find links to article
Di Paolo G, McCabe BD, et al. (February 2013). "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk". Neuron
Sharon Tooze (614 words) [view diff] exact match in snippet view article find links to article
independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition". Bioscience Reports. 38 (2): BSR20171669. doi:10.1042/BSR20171669
PAK6 (1,642 words) [view diff] exact match in snippet view article find links to article
junctional protein IQGAP1, E3 ligase Mdm2, and leucine-rich repeat kinase 2 (LRRK2). PAK6 has been shown to interact with Androgen receptor. GRCh38: Ensembl
Cyclin-dependent kinase 5 (5,367 words) [view diff] exact match in snippet view article find links to article
talin, drebrin, synapsin I, synapsin III, CRMP1, GKAP, SPAR, PSD-95, and LRRK2. The mammalian circadian clock is controlled by Cdk5 with the phosphorylation
FAM71E1 (1,222 words) [view diff] exact match in snippet view article find links to article
Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations". PLOS ONE. 11 (5): e0154890. Bibcode:2016PLoSO
C17orf53 (1,393 words) [view diff] exact match in snippet view article find links to article
proteins bearing a leucine-rich nuclear export signal (NES) and of RNAs LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 association 0.35 Anti
Edna Schechtman (1,621 words) [view diff] exact match in snippet view article find links to article
I., Gershoni-Baruch, R., Djaldetti, R., ... & Inzelberg, L. (2012). The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin
Chaperone-mediated autophagy (3,332 words) [view diff] exact match in snippet view article find links to article
Consiglio, A; Raya, A; Sulzer, D; Cuervo, AM (April 2013). "Interplay of LRRK2 with chaperone-mediated autophagy". Nature Neuroscience. 16 (4): 394–406
Epigenetics of neurodegenerative diseases (9,863 words) [view diff] exact match in snippet view article find links to article
the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and fibrillar accumulation of Lewy bodies from misfolded alpha-synuclein