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Longer titles found: List of breast cancer cell lines (view), Cancer Cell (journal) (view), Cancer Cell International (view), RNAi-Based Identification System and interference of Specific Cancer Cells (view)

searching for Cancer cell 476 found (2383 total)

alternate case: cancer cell

MRC Cancer Unit (293 words) [view diff] case mismatch in snippet view article find links to article

Biomedical Campus. The MRC Cancer Unit was established in 2001 (as the MRC Cancer Cell Unit) by Professor Ron Laskey CBE, who was also appointed as the unit's

ERX-11 (733 words) [view diff] exact match in snippet view article find links to article

the growth of the ZR-75 and MCF-7 breast cancer cell lines. It was inactive in ER-negative breast cancer cell lines. In contrast to conventional antiestrogens

Cixutumumab (617 words) [view diff] exact match in snippet view article find links to article

Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor

Apoptosis (10,857 words) [view diff] exact match in snippet view article find links to article

gene, resulting in the increase of p53 protein level and enhancement of cancer cell-apoptosis. p53 prevents the cell from replicating by stopping the cell

MCF-7 (1,169 words) [view diff] exact match in snippet view article find links to article

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute

MELK (977 words) [view diff] exact match in snippet view article find links to article

essential for cancer cell proliferation. However, recent research using CRISPR has demonstrated that MELK is fully dispensable for cancer cell growth, casting

G12/G13 alpha subunits (457 words) [view diff] exact match in snippet view article find links to article

cytoskeletal remodeling in cells during movement and migration, including cancer cell metastasis. G13 is also essential for receptor tyrosine kinase-induced

Mir-612 microRNA precursor family (216 words) [view diff] exact match in snippet view article find links to article

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. The microRNA miR-2185

NCI-60 (895 words) [view diff] exact match in snippet view article find links to article

The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds

Sofituzumab vedotin (164 words) [view diff] exact match in snippet view article find links to article

cytotoxic agent MMAE, which is released after internalization by the cancer cell. In addition to its direct cytotoxic effect, sofituzumab vedotin may

Miproxifene (300 words) [view diff] exact match in snippet view article find links to article

to be 3- to 10-fold more potent than tamoxifen in inhibiting breast cancer cell growth in in vitro models. Miproxifene is the active metabolite of miproxifene

NNC 45-0095 (280 words) [view diff] exact match in snippet view article find links to article

(EmaxTooltip maximal efficacy (relative to moxestrol, in Ishikawa endometrial cancer cell line) = 105%). The compound is a pyrrolo indolizine derivative. Its development

Bavituximab (680 words) [view diff] exact match in snippet view article find links to article

membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies, and when cells are infected with hepatitis C. The process of

Dauricine (376 words) [view diff] exact match in snippet view article find links to article

so. Dauricine has been studied in vitro for its potential to inhibit cancer cell growth and to block cardiac transmembrane Na+, K+, and Ca2+ ion currents

Miproxifene phosphate (329 words) [view diff] exact match in snippet view article find links to article

found to be 3- to 10-fold as potent as tamoxifen in inhibiting breast cancer cell growth in in vitro models. It is a derivative of afimoxifene (4-hydroxytamoxifen)

MAPK4 (602 words) [view diff] exact match in snippet view article find links to article

cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth. ENSG00000282110

Lipocalin (2,092 words) [view diff] exact match in snippet view article find links to article

transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. Lipocalin proteins are important key players of nutritional

MMP2 (2,812 words) [view diff] exact match in snippet view article find links to article

is an essential step for the metastatic progression of most cancers. Cancer cell invasion, ECM degradation, and metastasis are highly linked with the

Mir-145 (1,481 words) [view diff] exact match in snippet view article find links to article

and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80. doi:10.1038/onc

Robert Weinberg (biologist) (1,345 words) [view diff] exact match in snippet view article

century, advances in genetics led to the discovery of over one hundred cancer cell types. Cancer cells were noted for their bewildering diversity. It was

Trey Ideker (566 words) [view diff] case mismatch in snippet view article find links to article

for Network Biology, the San Diego Center for Systems Biology, and the Cancer Cell Map Initiative. He uses genome-scale measurements to construct network

Autocrine signaling (2,105 words) [view diff] exact match in snippet view article find links to article

mechanism for constitutive Wnt pathway activation in human cancer cells". Cancer Cell. 6 (5): 497–506. doi:10.1016/j.ccr.2004.09.032. PMID 15542433. Schlange

Antineoplastic resistance (3,844 words) [view diff] exact match in snippet view article find links to article

acquired resistance after drug exposure, which is rooted in the concept of cancer cell heterogeneity. Characteristics of resistant cells include altered membrane

Epithelial–mesenchymal transition (6,840 words) [view diff] exact match in snippet view article find links to article

and TGF-β receptor 2 in a pancreatic cancer cell line. Overexpression of the miR-655 mimic in the Panc1 cancer cell line upregulated the expression of E-cadherin

PTPRH (570 words) [view diff] exact match in snippet view article find links to article

level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. GRCh38: Ensembl release

Carnosol (174 words) [view diff] exact match in snippet view article find links to article

pachyphylla). It has been studied in-vitro for anti-cancer effects in various cancer cell types. Carnosic acid List of phytochemicals in food Ai-Hsiang Lo; Yu-Chih

DU145 (733 words) [view diff] exact match in snippet view article find links to article

(DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research

Pyrvinium (346 words) [view diff] exact match in snippet view article find links to article

pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation. One synthetic method is based on Skraup

2-Methoxyestradiol (916 words) [view diff] exact match in snippet view article find links to article

inhibitor. It also acts as a vasodilator and induces apoptosis in some cancer cell lines. 2-Methoxyestradiol is derived from estradiol, although it interacts

Annual Review of Cancer Biology (514 words) [view diff] exact match in snippet view article find links to article

Attardi and Scott A. Armstrong. It is content is broadly focused on cancer cell biology, tumorigenesis and cancer progression, and translational cancer

Tisagenlecleucel (1,806 words) [view diff] exact match in snippet view article find links to article

both a T-cell receptor and an antibody specific to a protein on the cancer cell, and transferred back to the person. The T cells are engineered to target

Reactive oxygen species (8,508 words) [view diff] exact match in snippet view article find links to article

inhibit cancer cell proliferation. Although ROS can promote tumor cell proliferation, a great increase in ROS has been associated with reduced cancer cell proliferation

Luis Jose De Souza (803 words) [view diff] case mismatch in snippet view article find links to article

Mumbai and Goa. He has also contributed to the establishment of Indian Cancer Cell, an educational program co-sponsored by Tata Memorial Centre, Union for

Zeranol (457 words) [view diff] exact match in snippet view article find links to article

under the brand name Ralone in Spain. Although zeranol may increase cancer cell proliferation in already existing breast cancer, dietary exposure from

Type IV collagen (2,425 words) [view diff] exact match in snippet view article find links to article

on the cancer cell surface that colocalize with the integrin receptors. The interaction between type IV collagen produced by the cancer cell, and integrins

Tumor promotion (251 words) [view diff] exact match in snippet view article find links to article

receptor. A tumor suppressor would trigger an apoptotic pathway in a cancer cell if there were DNA damage, polyploidy, or uncontrolled cell growth. Simultaneously

MDA-MB-453 (1,323 words) [view diff] exact match in snippet view article find links to article

MDA-MB-453 is a human breast cancer cell line. The MDA-MB-453 cell cancer line was derived in 1976 from the pericardial effusion of a 48-year-old female

Epothilone (2,166 words) [view diff] exact match in snippet view article find links to article

epothilones A to F have been identified and characterized. Early studies in cancer cell lines and human cancer patients indicate superior efficacy to the taxanes

Hyaluronan synthase (2,531 words) [view diff] exact match in snippet view article find links to article

effects and therapeutic potentials. HAS2 is overexpressed in breast cancer cell lines and is associated with lymph node metastasis, while HAS1 and HAS3

Peter MacCallum Cancer Centre (828 words) [view diff] case mismatch in snippet view article find links to article

the centre include the Australian Cancer Research Foundation (ACRF) Cancer Cell Biology Program and the ACRF Victorian Centre for Functional Genomics

Peter MacCallum Cancer Centre (828 words) [view diff] case mismatch in snippet view article find links to article

the centre include the Australian Cancer Research Foundation (ACRF) Cancer Cell Biology Program and the ACRF Victorian Centre for Functional Genomics

Mucin 4 (2,092 words) [view diff] exact match in snippet view article find links to article

been found for MUC4 using commercial mRNAs or total RNAs extracted from cancer cell lines. Some predicted forms are soluble, while others are membrane bound

MTA3 (1,763 words) [view diff] no match in snippet view article find links to article

Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell. 113 (2): 207–19. doi:10.1016/S0092-8674(03)00234-4. PMID 12705869.

Invadopodia (1,535 words) [view diff] exact match in snippet view article find links to article

their ability to invade through the extracellular matrix, especially in cancer cell extravasation. Invadopodia are generally visualized by the holes they

T-47D (285 words) [view diff] exact match in snippet view article find links to article

T-47D is a human breast cancer cell line commonly used in biomedical research involving the hormonal expression of cancer cells. The cells were derived

Molecular oncology (1,208 words) [view diff] exact match in snippet view article find links to article

antigen, the physical structure of the T cell changes to destroy the cancer cell. This is a method of cancer treatment that works on the cellular and

Intravasation (979 words) [view diff] exact match in snippet view article find links to article

metastatic sites. Cancer cell chemotaxis also relies on this migratory behavior to arrive at a secondary destination designated for cancer cell colonization

WNT6 (586 words) [view diff] exact match in snippet view article find links to article

overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression

Taxifolin (1,752 words) [view diff] exact match in snippet view article find links to article

ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. However, in this same study, taxifolin

MMP27 (1,345 words) [view diff] exact match in snippet view article find links to article

MMP-27 was also identified, at the protein level, in MDA-MB-231 breast cancer cell line and in primary human breast cancer. Recently, MMP-27 has been demonstrated

Oncogene (journal) (245 words) [view diff] exact match in snippet view article

peer-reviewed scientific journal published under the Springer Nature addressing cancer cell genetics and the structure and function of oncogenes. The journal has

Hep G2 (577 words) [view diff] exact match in snippet view article find links to article

Hep G2 (or HepG2) is a human liver cancer cell line. Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old

RAC1 (3,117 words) [view diff] exact match in snippet view article find links to article

tissues, deregulation of cell motility is one of the hallmark events in cancer cell invasion and metastasis. Overexpression of a constitutively active Rac1

Dose fractionation (776 words) [view diff] exact match in snippet view article find links to article

should be used in using results for a cancer cell line to make predictions for healthy cells if the cancer cell line is known to be resistant to cytotoxic

Metabolic pathway (3,004 words) [view diff] exact match in snippet view article find links to article

there are various pathways that can be targeted by compounds to prevent cancer cell proliferation. One such pathway is oxidative phosphorylation (OXPHOS)

GPR31 (1,651 words) [view diff] exact match in snippet view article find links to article

supported by studies that cloned the receptor from the PC-3 prostate cancer cell line. The cloned receptor, when expressed in other cell types, bound

CD3 (immunology) (757 words) [view diff] exact match in snippet view article

altering the co-stimulatory signal to help get the T-cell to recognize the cancer cell and become fully activated. Cancers that possess the B7-H3 immunoregulatory

Nilotinib (1,908 words) [view diff] exact match in snippet view article find links to article

kinase inhibitor and works by interfering with signalling within the cancer cell. Nilotinib was approved for medical use in the United States in 2007

HCT116 cells (406 words) [view diff] exact match in snippet view article find links to article

HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings. HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene

Aurora kinase C (1,969 words) [view diff] exact match in snippet view article find links to article

centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative

Pyrimidine dimer (1,947 words) [view diff] exact match in snippet view article find links to article

precipitate mutations within an organism's genome, potentially culminating in cancer cell formation. Unrectified lesions may also interfere with polymerase function

K562 cells (1,386 words) [view diff] exact match in snippet view article find links to article

which express MHC class-I A2 and A3. K562 cells are part of the NCI-60 cancer cell line panel used by the National Cancer Institute. Many factors and components

PC3 (1,810 words) [view diff] exact match in snippet view article find links to article

PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. PC3 cells are useful in investigating biochemical

Growth curve (biology) (482 words) [view diff] no match in snippet view article

A growth curve is an empirical model of the evolution of a quantity over time. Growth curves are widely used in biology for quantities such as population

MiR-150 (658 words) [view diff] exact match in snippet view article find links to article

miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than

ID4 (3,045 words) [view diff] exact match in snippet view article find links to article

also seen to be overexpressed in most ovarian, endometrial and breast cancer cell lines. The mechanism behind this is believed to be that ID4 regulates

Autologous immune enhancement therapy (2,109 words) [view diff] exact match in snippet view article find links to article

subjected to etc., Aberrant cell division takes place that ends up in a cancer cell and such aberrance may be due to faulty stem cell, abnormal genetic components

Cancer immunology (3,766 words) [view diff] exact match in snippet view article find links to article

cell-based cancer vaccine) Obeid et al. investigated how inducing immunogenic cancer cell death ought to become a priority of cancer chemotherapy. He reasoned

Mir-26 microRNA precursor family (3,054 words) [view diff] exact match in snippet view article find links to article

miR-26a delivery using adeno-associated virus (AAV) is able to inhibit cancer cell formation while also inducing tumour-specific apoptosis and providing

Cecropin (1,552 words) [view diff] exact match in snippet view article find links to article

concentrations on the order of 10−6 M. Two multidrug-resistant breast and ovarian cancer cell lines also showed sensitivity to the peptides. Further, peptide anticancer

ARID1A (1,807 words) [view diff] case mismatch in snippet view article find links to article

with ARID1A loss driving pre-memory B cell fate and lymphomagenesis". Cancer Cell. 42 (4): 583–604.e11. doi:10.1016/j.ccell.2024.02.010. PMC 11407687.

Isogenic human disease models (2,046 words) [view diff] exact match in snippet view article find links to article

from a normal to cancer genotype; or vice versa; in characterized human cancer cell lines such as HCT116 or Nalm6. There are several gene targeting technologies

BT-20 (125 words) [view diff] exact match in snippet view article find links to article

BT-20 is a breast cancer cell line derived from a 74-year-old human female in 1958 by E.Y. Lasfargues and L. Ozzello. The cells technically came from

Immunotherapy (6,093 words) [view diff] no match in snippet view article find links to article

under preliminary research for its potential to treat various forms of cancer. Cell-based immunotherapies are effective for some cancers. Immune effector

Modelling biological systems (2,156 words) [view diff] exact match in snippet view article find links to article

response to environmental and internal stimuli, such as a model of a cancer cell in order to find weaknesses in its signalling pathways, or modelling

Stanford Cancer Institute (469 words) [view diff] case mismatch in snippet view article find links to article

a donation by Jeffrey Rothschild established the Stanford Center for Cancer Cell Therapy, which supports research into the development of immunological

Dichlorophenolindophenol (386 words) [view diff] exact match in snippet view article find links to article

human cancer cells in an animal model of human melanoma; DCPIP-induced cancer cell death occurs by depletion of intracellular glutathione and upregulation

Sodium-coupled monocarboxylate transporter 1 (6,958 words) [view diff] exact match in snippet view article find links to article

also lower in three human cervical cancer cell lines (i.e., HeLa, abd, and CaSki cells) and a human uterus cancer cell line (i.e., SiHa cells) than normal

Eternal youth (1,092 words) [view diff] exact match in snippet view article find links to article

telomeres by adding bases to the ends and thus renewing the telomere. A cancer cell has in essence turned on the telomerase gene, and this allows them to

PFKFB4 (689 words) [view diff] exact match in snippet view article find links to article

6-biphosphatase 4 as an important regulator of prostate cancer cell survival". Cancer Discovery. 2 (4): 328–43. doi:10.1158/2159-8290.CD-11-0234

WNT9A (648 words) [view diff] exact match in snippet view article find links to article

gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity

CYP4F12 (1,376 words) [view diff] exact match in snippet view article find links to article

proliferation; and inhibit the growth and metastasis of human breast and prostate cancer cell lines. It is suggested that the EDP and EEQ metabolites function in humans

PANC-1 (244 words) [view diff] exact match in snippet view article find links to article

PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of ductal cell origin. PANC-1 was derived from the tissue of a 56-year-old

RUNX3 (1,848 words) [view diff] case mismatch in snippet view article find links to article

is a crucial early event in the development of lung adenocarcinoma". Cancer Cell. 24 (5): 603–616. doi:10.1016/j.ccr.2013.10.003. PMID 24229708. Lee JW

Marc Lacroix (biochemist) (2,387 words) [view diff] exact match in snippet view article

Body JJ (1998). "Establishment and characterization of three new breast-cancer cell lines". International Journal of Cancer. 76 (5): 677–683. doi:10

EEF1G (1,220 words) [view diff] exact match in snippet view article find links to article

Baffa R, Croce CM (August 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18):

MIA PaCa-2 (240 words) [view diff] exact match in snippet view article find links to article

MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development. In 1977, MIA PaCa-2 cells were

Cucurbitacin E (1,179 words) [view diff] exact match in snippet view article find links to article

shows cytotoxicity to: The colon cancer cell line HCT-116 The lung cancer cell line NCI-H460 The breast cancer cell lines MCF-7 and ZR-75-1 The central

Valspodar (103 words) [view diff] exact match in snippet view article find links to article

studies in animal models have found it to be effective at preventing cancer cell resistance to chemotherapeutics, but these findings did not translate

Debromoaplysiatoxin (2,188 words) [view diff] exact match in snippet view article find links to article

tumor promoter which has an anti-proliferative activity against various cancer cell lines in mice. The first reported case of seaweed dermatitis was from

NOSH-aspirin (170 words) [view diff] exact match in snippet view article find links to article

have found that four NOSH variants, evaluated in eleven different human cancer cell lines, were effective in inhibiting the growth of these cell lines. NOSH-1

Mir-127 (1,084 words) [view diff] exact match in snippet view article find links to article

proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells". Cancer Cell. 9 (6): 435–43. doi:10.1016/j.ccr.2006.04.020. PMID 16766263. Robertus

Cyclin-dependent kinase 2 (4,161 words) [view diff] case mismatch in snippet view article find links to article

linked to its melanocyte-specific transcriptional regulation by MITF". Cancer Cell. 6 (6): 565–76. doi:10.1016/j.ccr.2004.10.014. PMID 15607961. Hoek KS

LAPC4 (336 words) [view diff] exact match in snippet view article find links to article

culture dishes, where it can be propagated as an immortalized prostate cancer cell line. LAPC4 are a lowly adherent, epithelial cell line with high Androgen

BCAS1 (685 words) [view diff] exact match in snippet view article find links to article

region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However

Antibody–drug conjugate (4,329 words) [view diff] exact match in snippet view article find links to article

antibody–drug conjugate consists of 3 components: Antibody - targets the cancer cell surface and may also elicit a therapeutic response. Payload - elicits

Frizzled-7 (795 words) [view diff] exact match in snippet view article find links to article

et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation

Oleocanthal (1,218 words) [view diff] exact match in snippet view article find links to article

apoptosis. This is a result of lysosome membrane permeabilization promoting cancer cell death. Lysosomal membrane permeabilization is not activated by oleocanthal

VCaP (311 words) [view diff] exact match in snippet view article find links to article

culture dishes, where it can be propagated as an immortalized prostate cancer cell line. VCaP are an adherent, epithelial cell line with high Androgen receptor

Selinexor (2,715 words) [view diff] no match in snippet view article find links to article

exportin 1 and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests

Fluorescence microscope (2,725 words) [view diff] exact match in snippet view article find links to article

Epifluorescent imaging of the three components in a dividing human cancer cell. DNA is stained blue, a protein called INCENP is green, and the microtubules

Gastrointestinal cancer (3,243 words) [view diff] exact match in snippet view article find links to article

treatment depends on the location of the tumor, as well as the type of cancer cell and whether it has invaded other tissues or spread elsewhere. These factors

Mucin-16 (1,916 words) [view diff] exact match in snippet view article find links to article

and the human Fc portion has the ability to disrupt the heterotypic cancer cell adhesion mediated by the MUC16-mesothelin interaction. Mesothelin has

Craig B. Thompson (2,348 words) [view diff] exact match in snippet view article find links to article

transformation. This work has contributed to the resurgent interest in cancer cell metabolism and may form the basis for translational therapies to exploit

12-Hydroxyeicosatetraenoic acid (6,990 words) [view diff] exact match in snippet view article find links to article

production in cultured prostate cancer cell lines, have implicated 12-HETE (stereoisomer sometimes undefined) in cancer cell lines from various other human

S180 (147 words) [view diff] exact match in snippet view article find links to article

S180 is a murine Sarcoma cancer cell line. It has been commonly used in cancer research due to its rapid growth and proliferation in mice. The cell line

FOXO6 (461 words) [view diff] exact match in snippet view article find links to article

Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013). "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters. 587 (14): 2105–11

Karin Rodland (679 words) [view diff] exact match in snippet view article find links to article

Karin Dorinda Norlin Rodland (born 1949) is an American cancer cell biologist. She is a professor emeritus at Oregon Health and Science University. Rodland

HT-29 (1,768 words) [view diff] exact match in snippet view article find links to article

HT-29 is a human colon cancer cell line used extensively in biological and cancer research. The HT-29 cell line was established in 1964 from the tumor

Hippo signaling pathway (3,241 words) [view diff] exact match in snippet view article find links to article

mutated in familial and sporadic schwannomas. Additionally, several human cancer cell lines invoke mutations of the SAV1 and MOBK1B proteins. However, recent

FUT5 (480 words) [view diff] exact match in snippet view article find links to article

3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells". International

AGR2 (3,024 words) [view diff] exact match in snippet view article find links to article

Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response

Somatostatin receptor 1 (1,215 words) [view diff] exact match in snippet view article find links to article

expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sciences. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6

Mir-661 microRNA precursor family (249 words) [view diff] exact match in snippet view article find links to article

SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers". Oncogene. 29

4T1 (780 words) [view diff] exact match in snippet view article find links to article

4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine

Patient derived xenograft (3,639 words) [view diff] exact match in snippet view article find links to article

engraftment success. Unlike creating xenograft mouse models using existing cancer cell lines, there are no intermediate in vitro processing steps before implanting

Bromodeoxyuridine (1,088 words) [view diff] exact match in snippet view article find links to article

labeling concentrations, it is widely preferred for in vivo studies of cancer cell proliferation. However, at radiosensitizing concentrations, BrdU becomes

MLST8 (810 words) [view diff] exact match in snippet view article find links to article

hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited

RAD18 (1,207 words) [view diff] exact match in snippet view article find links to article

humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created. The protein encoded by this gene

RAD18 (1,207 words) [view diff] exact match in snippet view article find links to article

humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created. The protein encoded by this gene

MLST8 (810 words) [view diff] exact match in snippet view article find links to article

hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited

Ergtoxin (1,169 words) [view diff] exact match in snippet view article find links to article

cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line". Cancer Cell Int. 11 (6): 6. doi:10.1186/1475-2867-11-6. PMC 3063814. PMID 21392380

E-SCREEN (2,116 words) [view diff] exact match in snippet view article find links to article

bioassay measures estrogen-induced increase of the number of human breast cancer cell, which is biologically equivalent to the increase of mitotic activity

Xenotropic murine leukemia virus–related virus (2,683 words) [view diff] exact match in snippet view article find links to article

recombination between two mouse retroviruses during propagation of a prostate-cancer cell line in the mid-1990s. These findings raised serious questions concerning

Hair keratin (1,833 words) [view diff] exact match in snippet view article find links to article

structures, KRT81 expression has been observed in the SKBR3 human breast cancer cell line and metastatic lymph nodes of breast carcinomas, but not in normal

Cytostasis (1,232 words) [view diff] exact match in snippet view article find links to article

nitric oxide (NO) is able to have a cytostatic effect on the human breast cancer cell line MDA-MB-231. Not only does nitric oxide stop cell growth, the study

CD16 (1,844 words) [view diff] exact match in snippet view article find links to article

presence of specific antibodies, and can kill primary leukemic cells, cancer cell lines, and cells infected with hepatitis B virus. In addition, CD16 is

Monoclonal antibody (4,991 words) [view diff] exact match in snippet view article find links to article

and the myeloma partner has traits that make it immortal (similar to a cancer cell). This mixture of cells is then diluted and clones are grown from single

Mir-205 (2,700 words) [view diff] exact match in snippet view article find links to article

probability of survival. This down regulation was also observed in breast cancer cell lines, including MCF-7 and MDA-MB-231 compared to the non-malignant cell

Mir-624 microRNA precursor family (188 words) [view diff] exact match in snippet view article find links to article

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. miR-624 has been found

ANGPTL4 (3,023 words) [view diff] exact match in snippet view article find links to article

implicated in the metastatic process by modulating vascular permeability, cancer cell motility and invasiveness. The former name, FIAF, stands for Fasting-Induced

HOXC6 (1,241 words) [view diff] case mismatch in snippet view article find links to article

or proliferation when it was downregulated. According to a study in Cancer Cell International, suppression of the HOXC6 gene plays a role in blocking

N-alpha-acetyltransferase 10 (4,966 words) [view diff] exact match in snippet view article find links to article

"N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity". Cancer Cell. 19 (2): 218–231. doi:10.1016/j

Antiestrogen withdrawal response (293 words) [view diff] exact match in snippet view article find links to article

therapy in the breast to inhibit breast cancer growth and induce breast cancer cell death. The antiestrogen withdrawal syndrome is analogous to but less

BxPC-3 (322 words) [view diff] exact match in snippet view article find links to article

BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof. BxPC-3 cells were derived

Relda Marie Cailleau (1,654 words) [view diff] exact match in snippet view article find links to article

scientist primarily known for her establishment of a series of breast cancer cell lines that have been crucial to the discovery of anticancer drugs and

Protein AATF (1,226 words) [view diff] case mismatch in snippet view article find links to article

affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794. Di

ZR-75-1 (124 words) [view diff] exact match in snippet view article find links to article

ZR-75-1 is a human breast cancer cell line. Darbre PD, Daly RJ (December 1990). "Transition of human breast cancer cells from an oestrogen responsive

Homeobox protein CDX-1 (1,147 words) [view diff] exact match in snippet view article find links to article

"DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". The Journal of Biological Chemistry. 277 (39): 35795–35800. doi:10

MRN complex (3,079 words) [view diff] exact match in snippet view article find links to article

upregulation of MRN complex sub-units has been documented in certain cancer cell lines when compared to non-malignant somatic cells, suggesting some cancer

Cancer genome sequencing (3,085 words) [view diff] exact match in snippet view article find links to article

the characterization and identification of the DNA or RNA sequences of cancer cell(s). Unlike whole genome (WG) sequencing which is typically from blood

ALOX12 (3,928 words) [view diff] exact match in snippet view article find links to article

17-hydroxy-HDHA, have been shown to inhibit the growth of cultured human prostate cancer cell by causing them to enter apoptosis. Studies on rodents lacking or made

ARGLU1 (274 words) [view diff] exact match in snippet view article find links to article

protein required for estrogen-dependent gene transcription and breast cancer cell growth. The ARGLU1 gene expresses at least three distinct RNA splice

Mir-143 (1,573 words) [view diff] exact match in snippet view article find links to article

has shown to be effective in blocking cell cycle progression of lung cancer cell lines. Moreover, this combination treatment reduces angiogenesis. This

Rhabdastrella globostellata (267 words) [view diff] exact match in snippet view article find links to article

triterpene molecules with notable cytotoxic activity towards certain cancer cell lines. Swee Cheng Lim; Nicole de Voogd; Koh Siang Tan (2008). A guide

Measles virus encoding the human thyroidal sodium iodide symporter (639 words) [view diff] exact match in snippet view article find links to article

glycoprotein is a normal part of human tissue but may be overexpressed on some cancer cell types. MV-NIS is the first targeted engineered virus therapy to have

Mir-340 microRNA precursor family (386 words) [view diff] exact match in snippet view article find links to article

Zhang GH, Xu XC, Zhang N (July 2011). "miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met". Cancer

Oct-4 (4,168 words) [view diff] exact match in snippet view article find links to article

pluripotency in embryonic cells but also has the ability to regulate cancer cell proliferation and can be found in various cancers such as pancreatic

LARP4 (617 words) [view diff] exact match in snippet view article find links to article

that LARP4 is involved in mRNA stability. LARP4 is known to regulate cancer cell migration and invasion by altering cell shape. It is also reported to

Metastatic breast cancer (5,262 words) [view diff] exact match in snippet view article find links to article

nervous system. The main steps involved in the metastatic cascade of a cancer cell are: Cell division and growth within the primary tumor Invasion of the

Ichthyotoxin (466 words) [view diff] exact match in snippet view article find links to article

euglonophycin was demonstrated in leukemia, neuroblastoma, and colorectal cancer cell lines. Specifically, in colorectal cancer cells, euglenophycin exposure

Lycorine (1,201 words) [view diff] exact match in snippet view article find links to article

properties. It has displayed various inhibitory properties towards multiple cancer cell lines that include, lymphoma, carcinoma, multiple myeloma, melanoma,

Regorafenib (909 words) [view diff] exact match in snippet view article find links to article

increase EDP levels in and inhibit the growth of several human renal cancer cell lines in vitro and 2) dietary DHA likewise acted synergistically with

STEAP1 (484 words) [view diff] exact match in snippet view article find links to article

expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein

TRIM68 (501 words) [view diff] exact match in snippet view article find links to article

protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted

SK-OV-3 (447 words) [view diff] exact match in snippet view article find links to article

(also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with

CDKN1B (5,152 words) [view diff] exact match in snippet view article find links to article

These act to accelerate the proteolysis of the p27 protein and allow the cancer cell to undergo rapid division and uncontrolled proliferation. When p27 is

Phloretin (647 words) [view diff] exact match in snippet view article find links to article

and tested for its anticancer activity. Pht-GNPs showed significant cancer cell toxicities compared to free phloretin. Phlorizin is the 2'-glucoside

Binucleated cells (471 words) [view diff] exact match in snippet view article find links to article

carcinoma, cell line UPCI-SCC-103. A: The cancer cell treated with antibodies against tubulin. B: The same cancer cell stained with DAPI, highlighting the nuclei

CARM1 (588 words) [view diff] exact match in snippet view article find links to article

arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate. 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743

4-Hydroxyestrone (1,093 words) [view diff] exact match in snippet view article find links to article

from stress and damage. In 2024, a study demonstrated 4-OHE1's role in cancer cell survival and its potential therapeutics for breast cancer treatment.

Korea Research Institute of Bioscience and Biotechnology (356 words) [view diff] exact match in snippet view article find links to article

accomplishments include the development of a genome capable of controlling cancer cell proliferation and the identification of a neuropeptide Y-based growth

Carcinoembryonic antigen peptide-1 (65 words) [view diff] exact match in snippet view article find links to article

carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small-cell lung. Synonyms:

Calu-3 (429 words) [view diff] exact match in snippet view article find links to article

Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory

Mir-129 microRNA precursor family (1,700 words) [view diff] exact match in snippet view article find links to article

the aberrant regulation of miR-129 contributes to the proliferation of cancer cell lines. SOX4 is involved in the mediation of transcription response to

Mir-129 microRNA precursor family (1,700 words) [view diff] exact match in snippet view article find links to article

the aberrant regulation of miR-129 contributes to the proliferation of cancer cell lines. SOX4 is involved in the mediation of transcription response to

Patellamide A (523 words) [view diff] exact match in snippet view article find links to article

show moderate cytotoxicity and activity against multidrug resistant cancer cell lines. Patellamide A was first isolated in 1981 from the tunicate L.

SMARCA4 (2,714 words) [view diff] exact match in snippet view article find links to article

ATPase in cancer. Mutations in this gene were first recognized in human cancer cell lines derived from adrenal gland and lung. Later it was recognized that

Cruentaren (221 words) [view diff] exact match in snippet view article find links to article

yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro, including a multidrug-resistant KB line. Cruentaren B

Secretomics (2,140 words) [view diff] exact match in snippet view article find links to article

cancer secretomics are cancer cell line supernatants and proximal biological fluids, the fluids in contact with a tumor. Cancer cell line supernatant is

Mir-9/mir-79 microRNA precursor family (1,744 words) [view diff] no match in snippet view article find links to article

RM, Calin GA (2010). "MYC-microRNA-9-metastasis connection in breast cancer". Cell Res. 20 (6): 603–4. doi:10.1038/cr.2010.70. hdl:1822/67519. PMID 20502442

Mir-200 (2,072 words) [view diff] exact match in snippet view article find links to article

colonization at distant tissues. In a series of mouse mammary isogenic cancer cell lines, the miR-200 family is highly expressed only in the cells that

ErbB (2,736 words) [view diff] case mismatch in snippet view article find links to article

ErbB signaling from the structure of the ErbB2-pertuzumab complex". Cancer Cell. 5 (4): 317–328. doi:10.1016/S1535-6108(04)00083-2. PMID 15093539. Bouyain

Cadherin-2 (3,399 words) [view diff] exact match in snippet view article find links to article

cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the

Mucin short variant S1 (2,926 words) [view diff] exact match in snippet view article find links to article

also prevents the interaction of immune cells with receptors on the cancer cell surface through steric hindrance. This inhibits an anti-tumor immune

Perinucleolar compartment (1,123 words) [view diff] exact match in snippet view article find links to article

the prevalence is less than 5% in normal cell lines, but 15-100% in cancer cell lines. The PNC is directly proportional to metastasis as well as linked

Axel Ullrich (913 words) [view diff] exact match in snippet view article find links to article

these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ultimately tumor shrinkage. In the early 1990s, Ullrich and

KBM-7 cells (688 words) [view diff] exact match in snippet view article find links to article

myelogenous leukemia (CML) cell line used for biomedical research. Like all cancer cell lines, it is immortal and can divide indefinitely. A unique aspect of

P16 (4,271 words) [view diff] exact match in snippet view article find links to article

range of cancers, and alterations of the gene are frequently seen in cancer cell lines. Examples include: Pancreatic adenocarcinoma is often associated

George C. Prendergast (1,230 words) [view diff] case mismatch in snippet view article find links to article

research center in the U.S. He is also the co-director of the Program in Cancer Cell Biology & Signaling at the Sidney Kimmel Cancer Center, Thomas Jefferson

Degradome sequencing (2,432 words) [view diff] exact match in snippet view article find links to article

performed in two breast cancer cell lines in mice which were phenotypically distinct. One of these was a stem-cell like breast cancer cell line that altered

HEPACAM (1,060 words) [view diff] exact match in snippet view article find links to article

a) modulating cell-matrix adhesion and migration, and b) inhibiting cancer cell growth. (Note: *HEPACAM, gene name; **hepaCAM, protein name) Through

PVT1 (1,037 words) [view diff] exact match in snippet view article find links to article

CpG island on its promoter region, promoting the suppression of the cancer cell apoptosis. Furthermore, activity of lncPVT1 and its associated microRNAs

Forkhead box C1 (1,682 words) [view diff] no match in snippet view article find links to article

Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer". Cell Reports. 13 (5): 1046–1058. doi:10.1016/j.celrep.2015.09.063. PMC 4806384

Fangchinoline (112 words) [view diff] exact match in snippet view article find links to article

tetrandra. It has in vitro antiproliferative activity against a breast cancer cell line. Xie, Zhisheng; Xu, Xinjun; Xie, Chunyan; Liang, Zhikun; Yang, Mei;

U0126 (743 words) [view diff] exact match in snippet view article find links to article

Cdk2 and Cdk4. The effects of U0126 on the growth of eight human breast cancer cell lines shown that U0126 selectively repressed anchorage-independent growth

DACH1 (2,731 words) [view diff] exact match in snippet view article find links to article

tumors. DACH1 inhibits Cyclin D1 expression and thereby reduces breast cancer cell line cell growth. Normal cells and some breast cancer cells have receptors

CDC42 (3,700 words) [view diff] exact match in snippet view article find links to article

attachment to endothelial cells as well. Knocking down β1 integrin inhibited cancer cell migration, whereas overexpressing the integrin in Cdc42-deficient cells

Dihydroartemisinin (998 words) [view diff] exact match in snippet view article find links to article

discovered that artemisinin targets a broad spectrum of proteins in the human cancer cell proteome through heme-activated radical alkylation. Dihydroartemisinin

Exosome (vesicle) (7,565 words) [view diff] exact match in snippet view article

in biorepositories can be used for biomarker analysis as colorectal cancer cell-derived exosomes spiked into blood plasma could be recovered after 90

STAU1 (2,553 words) [view diff] exact match in snippet view article find links to article

dysregulation on cells and organs. STAU1 dysregulation may play a role in cancer cell development and progression. STAU1 has been associated with maintaining

Mir-190 microRNA precursor family (521 words) [view diff] exact match in snippet view article find links to article

Yao Q, Chen C (April 2009). "Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis". World Journal

Cell adhesion molecule 1 (1,186 words) [view diff] exact match in snippet view article find links to article

"Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines". Jpn. J. Cancer Res. 93 (8): 857–60. doi:10.1111/j.1349-7006.2002

Actibind (1,363 words) [view diff] exact match in snippet view article find links to article

ACTIBIND Experiments in vitro Cancer Cell Colony Formation In order to determine the effects of ACTIBIND on cancer cell colony formation, a study done

Piscarinine (159 words) [view diff] exact match in snippet view article find links to article

derivatives piscarinines A and B were shown to be active against the prostate cancer cell line LNCAP (IC50 values were 2.2 and 1.9 μg/mL for piscarinine A and

Fagonia (679 words) [view diff] exact match in snippet view article find links to article

much more effective than an aqueous extract at causing MCF-7 breast cancer cell death and inhibiting further cell multiplication. As of February 2025[update]

Diane Barber (2,349 words) [view diff] exact match in snippet view article find links to article

and national scientific conferences. One focus of her research is on cancer cell biology, specifically in regards to the pHi (intracellular pH) of cancer

KIF19 (132 words) [view diff] exact match in snippet view article find links to article

alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". doi:10.1101/2020.09.04.282657. S2CID 221589215. {{cite journal}}:

Michael J. Weber (461 words) [view diff] exact match in snippet view article find links to article

University of Virginia School of Medicine. His work focused on understanding cancer cell signaling as a potential target for cancer therapies. Born in 1942 to

COX7A2L (590 words) [view diff] exact match in snippet view article find links to article

This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents

Rho-associated protein kinase (2,181 words) [view diff] exact match in snippet view article find links to article

along with MRCKα/β kinases have been implicated in the plasticity of cancer cell migration, the phenomenon which bestows survival advantage to the cancer

Arachidonate 5-lipoxygenase (7,553 words) [view diff] exact match in snippet view article find links to article

of human cancer tumors in vivo as well as in various types of human cancer cell lines in vitro; these tumors and cell lines include those of the pancreas

MAP3K3 (1,820 words) [view diff] exact match in snippet view article find links to article

with colon and rectal cancers. MEKK3 is highly expressed in 4 ovarian cancer cell lines (OVCA429, Hey, DOV13, and SKOv3). This expression level is significantly

Marie Celeste Simon (303 words) [view diff] exact match in snippet view article find links to article

of Pennsylvania Perelman School of Medicine. Her research focuses on cancer cell metabolism, angiogenesis, and immunology. Simon earned a B.A. from Miami

Phosphofructokinase 2 (4,253 words) [view diff] exact match in snippet view article find links to article

particularly implicated as being modified and hyper-expressed for prostate cancer cell survival. Because this enzyme family maintains rates of glycolysis and

GOT2 (1,683 words) [view diff] exact match in snippet view article find links to article

NADH into mitochondria to ensure a high rate of glycolysis in diverse cancer cell lines. In a study completed in 2008, inhibiting the malate-aspartate

Methylselenocysteine (532 words) [view diff] exact match in snippet view article find links to article

proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture." Apoptosis has been proposed as the most plausible

Calcium-binding mitochondrial carrier protein SCaMC-1 (361 words) [view diff] exact match in snippet view article find links to article

Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated

Pyruvate dehydrogenase kinase (1,711 words) [view diff] exact match in snippet view article find links to article

cancerous cells. Similarly, PDK3 has been shown to be overexpressed in colon cancer cell lines. Three proposed inhibitors are AZD7545 and dichloroacetate which

Gloiopeltis furcata (263 words) [view diff] exact match in snippet view article find links to article

show that extracts of G. furcata inhibit the growth of several human cancer cell lines, and can significantly lower blood glucose levels. G. furcata's

Alberto Bardelli (1,450 words) [view diff] case mismatch in snippet view article find links to article

of Individual Metastases during HER2 Blockade in Colorectal Cancer". Cancer Cell. 34 (1): 148–162.e7. doi:10.1016/j.ccell.2018.06.004. ISSN 1878-3686

Torreyanic acid (1,096 words) [view diff] exact match in snippet view article find links to article

natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 μg/mL, ranging from 3.5 (NEC)

Ferrocene (5,401 words) [view diff] exact match in snippet view article find links to article

inhibitory activity against human lung cancer cell line A549, colorectal cancer cell line HCT116, and breast cancer cell line MCF-7. An experimental drug was

Berkeleydione (75 words) [view diff] exact match in snippet view article find links to article

isolated from a Penicillium species that has in vitro activity in a cancer cell line. It was first discovered in fungal species which evolved to live

Terry Speed (1,162 words) [view diff] exact match in snippet view article find links to article

(2006). "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes". Cancer Cell. 10 (6): 515–27. doi:10.1016/j.ccr

Dideoxyverticillin A (419 words) [view diff] exact match in snippet view article find links to article

exhibits antiangiogenic activity, and has efficacy against several cancer cell lines. Its reported anticancer mechanism is that it acts as a farnesyl

Mir-126 (2,258 words) [view diff] exact match in snippet view article find links to article

is reduced in gastric cancer. mir-126 expression is reduced in lung cancer cell lines. mir-126 expression is reduced in prostate cancer and bladder cancer

Period circadian protein homolog 1 (2,049 words) [view diff] exact match in snippet view article find links to article

circadian clock may play a large role in its likelihood of developing into a cancer cell. PER1 is a gene that plays an important role in such a circadian mechanism

ABCC5 (1,385 words) [view diff] exact match in snippet view article find links to article

of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Cancer Research. 57 (16): 3537–47. PMID 9270026. Suzuki T, Nishio

Melipona scutellaris (2,412 words) [view diff] exact match in snippet view article find links to article

source of antibiofilm agents and to present selectivity against human cancer cell lines at low concentrations compared to normal cells. M. scutellaris

TEAD1 (4,085 words) [view diff] exact match in snippet view article find links to article

complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression Moreover, VGLL2 interaction

Rakesh Jain (704 words) [view diff] case mismatch in snippet view article find links to article

Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell, 26: 605-22, 2014 Jain, RK. Normalizing tumor vasculature with anti-angiogenic

LZTS1 (546 words) [view diff] case mismatch in snippet view article find links to article

interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC 1987708. PMID 17349584

Danny Welch (531 words) [view diff] exact match in snippet view article find links to article

In 1996, Welch's lab in Hershey, Pennsylvania, isolated a cDNA from a cancer cell that was not able to undergo metastasis after the human chromosome 6

PPM1D (1,172 words) [view diff] exact match in snippet view article find links to article

cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in

William H. Andrews (biologist) (1,052 words) [view diff] exact match in snippet view article

discovery, and the demonstration that the anti-sense of hTR could kill every cancer cell tested, Andrews and 3 members of his team were awarded second place for

Betulinic acid (1,916 words) [view diff] exact match in snippet view article find links to article

C-3 phthalates derivatives exhibited higher cytotoxic activity against cancer cell lines with improved selective toxicity and water solubility. Chatterjee

U-87 MG (365 words) [view diff] exact match in snippet view article find links to article

"U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line". PLOS Genet. 6 (1): e1000832. doi:10.1371/journal.pgen.1000832

Victoria Sanz-Moreno (558 words) [view diff] exact match in snippet view article find links to article

Victoria Sanz Moreno is a Spanish scientist. She is professor of cancer cell and metastasis biology at The Institute of Cancer Research. Sanz-Moreno was

Caffeic acid (2,028 words) [view diff] exact match in snippet view article find links to article

studies and in animal models, and the inhibitory effect of caffeic acid on cancer cell proliferation by an oxidative mechanism in the human HT-1080 fibrosarcoma

Metastasis suppressor (1,578 words) [view diff] exact match in snippet view article find links to article

RHoGD12 is active in bladder cancer and inhibits proteins that aid in cancer cell migration. RhoGDI2 suppresses endothelin 1 (ET1), a vasoconstrictor correlated

Atranorin (492 words) [view diff] exact match in snippet view article find links to article

August 2017). "The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis". Scientific Reports. 7 (1): 8136. Bibcode:2017NatSR

MIR489 (557 words) [view diff] exact match in snippet view article find links to article

between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth". Oncotarget. 7 (14): 18295–308. doi:10

Scott W. Lowe (950 words) [view diff] exact match in snippet view article find links to article

discovered mechanisms whereby senescence inducing therapies promote cancer cell immune surveillance. In 2015, Lowe continued his use of RNAi to study

GPR158 (457 words) [view diff] exact match in snippet view article find links to article

androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation. GRCh38: Ensembl

N-Myc (1,978 words) [view diff] case mismatch in snippet view article find links to article

of N-Myc is a critical function of Aurora A in human neuroblastoma". Cancer Cell. 15 (1): 67–78. doi:10.1016/j.ccr.2008.12.005. PMID 19111882. Gustafson

4-Hydroxybenzoic acid (1,925 words) [view diff] exact match in snippet view article find links to article

both in vitro and in vivo, and stimulates the growth of human breast cancer cell lines. It is a common metabolite of paraben esters, such as methylparaben

SNP array (1,774 words) [view diff] exact match in snippet view article find links to article

DNA copy number profile for the T47D breast cancer cell line (Affymetrix SNP Array)

RNF14 (1,058 words) [view diff] exact match in snippet view article find links to article

inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327

ERG (gene) (2,303 words) [view diff] exact match in snippet view article

oligonucleotides have been used to induce exon 4 skipping in prostate cancer cell lines, mouse models and tissue explants, leading to anti-cancer effects

MiR-296 (436 words) [view diff] case mismatch in snippet view article find links to article

growth factor receptor overexpression in angiogenic endothelial cells". Cancer Cell. 14 (5): 382–93. doi:10.1016/j.ccr.2008.10.005. PMC 2597164. PMID 18977327

Inflammation (9,751 words) [view diff] exact match in snippet view article find links to article

mutagenic DNA damages. A normal cell may undergo carcinogenesis to become a cancer cell if it is frequently subjected to DNA damage during long periods of chronic

Mir-615 microRNA precursor family (336 words) [view diff] exact match in snippet view article find links to article

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. Nasopharyngeal carcinoma-associated

Photopharmacology (3,771 words) [view diff] exact match in snippet view article find links to article

paper an in vitro protocol to test different light wavelengths on human cancer cell lines is developed, finding that blue light most effectively inhibited

TEAD2 (2,030 words) [view diff] exact match in snippet view article find links to article

complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression. The interaction between

Mothers against decapentaplegic homolog 4 (3,335 words) [view diff] exact match in snippet view article find links to article

(November 2007). "High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts

EMBiology (226 words) [view diff] case mismatch in snippet view article find links to article

gov) Tamoxifen has a positive "Clinical Trial" relationship with breast cancer Cell Expression Expression of proteins within or on the surface of a cell

David Tuveson (2,337 words) [view diff] case mismatch in snippet view article find links to article

invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4:437-450 (2003) Hingorani, S.R., Wang, L., Multani, A.S., Combs, C

Cell cycle analysis (1,531 words) [view diff] exact match in snippet view article find links to article

effective DNA repair, which may prevent transformation of normal into a cancer cell (carcinogenesis), or to cell death, often by the mode of apoptosis. An

KLK9 (538 words) [view diff] exact match in snippet view article find links to article

skin. KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian and

5-Oxo-eicosatetraenoic acid (4,378 words) [view diff] exact match in snippet view article find links to article

suggested that 5-oxo-ETE contributes to the development of inflammation, cancer cell growth, and other pathological and physiological events. In the most

Merkel cell polyomavirus (4,234 words) [view diff] exact match in snippet view article find links to article

in 1972 as "trabecular tumor of the skin". Based on its origin, the cancer cell type is called a neuroectodermal tumor. Although rare compared with other

Carbon nanotubes in medicine (3,860 words) [view diff] exact match in snippet view article find links to article

multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Biological systems are known to be highly transparent to

Sarcosine dehydrogenase (1,589 words) [view diff] exact match in snippet view article find links to article

epithelial cells increases the concentration of sarcosine and increase cancer cell invasions while the removal of either dimethylglycine dehydrogenase or

Troglitazone (2,044 words) [view diff] exact match in snippet view article find links to article

novel troglitazone derivatives with antiproliferative activity in breast cancer cell lines. In 2009, Pfizer resolved all but three of 35,000 claims over its

SLC45A3 (717 words) [view diff] exact match in snippet view article find links to article

significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3. There is

Simone Badal-McCreath (391 words) [view diff] exact match in snippet view article find links to article

creating the first cancer cell line from the Caribbean in 2022 during the COVID-19 pandemic. The intent was to create more cancer cell lines for black people

PRDX3 (1,206 words) [view diff] exact match in snippet view article find links to article

that peroxiredoxin 3 is overexpressed in prostate cancer and promotes cancer cell survival by defending cells against the damages incurred by oxidative

KDM4A (1,569 words) [view diff] exact match in snippet view article find links to article

pathways such as p53. Suppression of Kdm4a in breast cancer cell lines has shown to reduce cancer cell proliferation through cell cycle arrest, and decrease

Tannishtha Reya (555 words) [view diff] exact match in snippet view article find links to article

publication in 2001 coining the term "cancer stem cell" to describe a cancer cell that mirrors the properties of stem cells of healthy organs in the context

P38 mitogen-activated protein kinases (1,385 words) [view diff] exact match in snippet view article find links to article

activity can activate genes that cause cancer cell survival, and can also activate genes that facilitate cancer cell metastasis to other tissues. P38 was

Warburg effect (oncology) (3,011 words) [view diff] exact match in snippet view article

PMID 37922928. Alfarouk KO (December 2016). "Tumor metabolism, cancer cell transporters, and microenvironmental resistance". Journal of Enzyme Inhibition

Crotogoudin (63 words) [view diff] exact match in snippet view article find links to article

studies, it showed antiproliferative activity against various human cancer cell lines. Breitler, Simon; Carreira, Erick M. (2013). "Total Synthesis of

Mike Berridge (biologist) (1,599 words) [view diff] exact match in snippet view article

(born 1946) is a New Zealand cell biologist. Since 1976, he has led the cancer cell and molecular biology research group at the Malaghan Institute of Medical

Dostarlimab (3,221 words) [view diff] exact match in snippet view article find links to article

(30 July 2014), Diagram showing a monoclonal antibody attached to a cancer cell., archived from the original on 6 August 2022, retrieved 4 August 2022

Immunohistochemistry (3,591 words) [view diff] exact match in snippet view article find links to article

typically from the spleen. The antibody producing cell is then fused with a cancer cell line. This causes the antibodies to show specificity for a single epitope

EGLN3 (856 words) [view diff] case mismatch in snippet view article find links to article

familial pheochromocytoma genes: developmental culling and cancer". Cancer Cell. 8 (2): 155–67. doi:10.1016/j.ccr.2005.06.015. PMID 16098468. Hopfer

Biosensor (12,175 words) [view diff] exact match in snippet view article find links to article

transferrin that would potentially attach to transferrin receptors on cancer cell surfaces. There is very high selectivity for transferrin receptors because

ADGRL4 (443 words) [view diff] case mismatch in snippet view article find links to article

endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637

Australian Cancer Research Foundation (359 words) [view diff] exact match in snippet view article find links to article

Centre, Melbourne For new technologies to identify genes controlling cancer cell behaviour $2,500,000 QLD Institute for Molecular Bioscience, University

PAK4 (3,029 words) [view diff] exact match in snippet view article find links to article

implications in a number of disease conditions, exemplified by oncogenesis, cancer cell invasion and metastasis. PAK4 has been shown to interact with: CDC42

Devimistat (240 words) [view diff] exact match in snippet view article find links to article

on the tricarboxylic acid cycle and inhibiting enzymes involved with cancer cell energy metabolism. A lipoic acid derivative different from standard cytotoxic

Azamulin (174 words) [view diff] exact match in snippet view article find links to article

S2CID 1866233. Mitra R, Goodman OB (April 2015). "CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR". The Prostate. 75

Geminin (1,608 words) [view diff] exact match in snippet view article find links to article

S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNA interference results in re-replication

CREB-binding protein (5,272 words) [view diff] exact match in snippet view article find links to article

diseases, association of CBP with β-catenin has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads

L-733,060 (1,038 words) [view diff] exact match in snippet view article find links to article

apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2". Investigational New Drugs. 26 (2): 111–8. doi:10.1007/s10637-007-9087-y

Drupanol (161 words) [view diff] exact match in snippet view article find links to article

"Bakuchiol inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity". Tianjin

Cadherin (3,588 words) [view diff] exact match in snippet view article find links to article

but also may affect signal transduction, leading to uncontrollable cancer cell growth. In epithelial cell cancers, disrupted cell-to-cell adhesion might

ACT Biotech Inc (272 words) [view diff] exact match in snippet view article find links to article

that targets cancer cells through multiple modes of action. It inhibits cancer cell growth by targeting the FGF receptor family, which are mutated in a number

Cordycepin (1,853 words) [view diff] exact match in snippet view article find links to article

renal, colon, and breast cancer. Cordycepin reduces viable A549 lung cancer cell populations by 50%. By acting at RUVBL2, cordycepin is the most potent

Collagen, type XXIII, alpha 1 (1,559 words) [view diff] exact match in snippet view article find links to article

loss of collagen XXIII may complicate cellular adhesion and reduce lung cancer cell retention. Collagen Protein domain Transmembrane protein Non-small-cell

Mir-885 microRNA precursor family (820 words) [view diff] exact match in snippet view article find links to article

K. (2015-04-09). "MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking

Mir-22 (791 words) [view diff] exact match in snippet view article find links to article

microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples". FEBS J. 277 (7): 1684–94. doi:10.1111/j

P-selectin (2,589 words) [view diff] exact match in snippet view article find links to article

on a key role in metastasis of the tumor. However, in the 4T1 breast cancer cell line, E-selectin reactivity is sLe(x) dependent while P-selectin reactivity

Epithelial cell adhesion molecule (2,451 words) [view diff] exact match in snippet view article find links to article

EpCAM in cancer tissue, where it is homogeneously distributed on the cancer cell surface. In addition to being overexpressed in many carcinomas, EpCAM

Itraconazole (2,451 words) [view diff] case mismatch in snippet view article find links to article

Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth". Cancer Cell. 17 (4): 388–99. doi:10.1016/j.ccr.2010.02.027. PMC 4039177. PMID 20385363

Mothers against decapentaplegic homolog 3 (4,115 words) [view diff] exact match in snippet view article find links to article

angiogenesis. Studies analyzing SMAD3 levels of expression in prostate cancer cell lines found that the two androgen-independent and androgen receptor-negative

Gene set enrichment analysis (4,624 words) [view diff] no match in snippet view article find links to article

Gene set enrichment analysis (GSEA) (also called functional enrichment analysis or pathway enrichment analysis) is a method to identify classes of genes

LNCaP (1,754 words) [view diff] exact match in snippet view article find links to article

Keller ET (May 2001). "Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro" (PDF). Prostate. 47 (3): 212–21. doi:10.1002/pros

Joan Massagué (1,400 words) [view diff] case mismatch in snippet view article find links to article

"A multigenic program mediating breast cancer metastasis to bone". Cancer Cell. 3 (6): 537–49. doi:10.1016/s1535-6108(03)00132-6. PMID 12842083. Minn

SWI/SNF (3,947 words) [view diff] exact match in snippet view article find links to article

Early studies identified that SWI/SNF subunits were frequently absent in cancer cell lines. SWI/SNF was first identified in 1998 as a tumor suppressor in

TNK2 (1,756 words) [view diff] case mismatch in snippet view article find links to article

Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer. Cancer Cell, 31(6), 790-803.e8. https://doi.org/10.1016/j.ccell.2017.05.003 ‌ GRCh38:

Philadelphia chromosome (5,538 words) [view diff] case mismatch in snippet view article find links to article

through the inhibitory activity of the BCR/ABL-regulated SET protein". Cancer Cell. 8 (5): 355–368. doi:10.1016/j.ccr.2005.10.015. PMID 16286244. Trotta

RAD51 (5,526 words) [view diff] exact match in snippet view article find links to article

seen in BRCA1 deficiency), resulting in increased HRR that may enable cancer cell survival by partially ameliorating the excess of DNA damage. Under-expression

Cathepsin Z (1,784 words) [view diff] exact match in snippet view article find links to article

cellular adhesion and phagocytosis. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may

NFKB1 (2,363 words) [view diff] case mismatch in snippet view article find links to article

"Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way". Cancer Cell. 3 (3): 201–2. doi:10.1016/S1535-6108(03)00049-7. PMID 12676577. Sun

Interleukin 30 (1,800 words) [view diff] exact match in snippet view article find links to article

tumor suppressor genes, IL-30 favors cancer cell proliferation, migration, and dissemination. That may boost cancer cell expression of cytokines and chemokines

Dichapetalins (175 words) [view diff] exact match in snippet view article find links to article

moieties. They have been found to display cytotoxicity against several cancer cell lines. Tuchinda, Patoomratana; Kornsakulkarn, Jittra; Pohmakotr, Manat;

KIF20A (945 words) [view diff] exact match in snippet view article find links to article

trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell". Cancer Res. 65 (1): 105–12. doi:10.1158/0008-5472.105.65.1. PMID 15665285

Digital pathology (2,635 words) [view diff] exact match in snippet view article find links to article

chromatin, and therefore results in weak signals for the cancer cell output. These weak signals may result in a false positive result for a cancer cell.

HMBOX1 (452 words) [view diff] exact match in snippet view article find links to article

RNA-seq and ChIP-seq see little to no such effect at least in several cancer cell lines. GRCh38: Ensembl release 89: ENSG00000147421 – Ensembl, May 2017

STK11 (2,791 words) [view diff] exact match in snippet view article find links to article

mediated by oestrogen receptor alpha. However, in ER-positive breast cancer cell line MCF-7, estradiol caused a dose-dependent decrease in LKB1 transcript

NKX3-1 (2,366 words) [view diff] exact match in snippet view article find links to article

androgen receptor-positive prostate cancer cell line, but was absent from androgen receptor-negative prostate cancer cell lines as well as other cell lines

Fusobacterium nucleatum (869 words) [view diff] exact match in snippet view article find links to article

and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration". doi:10.1101/2020.01.15.907931. S2CID 213030137. Retrieved

Genistin (754 words) [view diff] exact match in snippet view article find links to article

phytoestrogen as it was shown to stimulate estrogen-dependent breast cancer cell growth in vivo. At a concentration of 1200 ppm, genistin caused significant

Mir-17 microRNA precursor family (4,138 words) [view diff] exact match in snippet view article find links to article

pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion". Cancer Biol Ther. 10 (8): 748–757. doi:10

P70-S6 Kinase 1 (2,099 words) [view diff] exact match in snippet view article find links to article

this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate

6-Phosphogluconate dehydrogenase (538 words) [view diff] exact match in snippet view article find links to article

hereditary disease affecting the red blood cells. 6PGD is involved in cancer cell metabolism so 6PGD inhibitors have been sought. Parietin, a 6PGD inhibitor

40S ribosomal protein S29 (846 words) [view diff] exact match in snippet view article find links to article

(February 2003). "Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis". Protein and

Adecatumumab (243 words) [view diff] exact match in snippet view article find links to article

cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". British Journal of Cancer. 92 (2): 342–9. doi:10.1038/sj.bjc

NCAPH (1,275 words) [view diff] exact match in snippet view article find links to article

supplementally, when NCAPH is depleted, studies show a decrease in colon cancer cell proliferation. Studies show that high expression of NCAPH in colon cancer

7β-Hydroxyepiandrosterone (237 words) [view diff] exact match in snippet view article find links to article

7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines" (PDF). Steroids. 77 (5): 542–51. doi:10.1016/j.steroids.2012.01

EIF3H (850 words) [view diff] exact match in snippet view article find links to article

Lehtonen HJ, Visakorpi T (2006). "Overexpression of EIF3S3 promotes cancer cell growth". Prostate. 66 (11): 1144–50. doi:10.1002/pros.20452. PMID 16652384

MTDH (1,727 words) [view diff] case mismatch in snippet view article find links to article

cell surface protein in breast tumors that mediates lung metastasis". Cancer Cell. 5 (4): 365–74. doi:10.1016/S1535-6108(04)00079-0. PMID 15093543. Sutherland

Ron Laskey (561 words) [view diff] case mismatch in snippet view article find links to article

Professor Sir John Gurdon. In 2001, he founded the Medical Research Council Cancer Cell Unit in 2001, and was Director of the Unit until 2010. Laskey is also

CXCR4 (2,660 words) [view diff] case mismatch in snippet view article find links to article

"Tumor entrained neutrophils inhibit seeding in the premetastatic lung". Cancer Cell. 20 (3): 300–14. doi:10.1016/j.ccr.2011.08.012. PMC 3172582. PMID 21907922

Breast cancer classification (9,469 words) [view diff] exact match in snippet view article find links to article

the tumor, and the expression of proteins and genes. As knowledge of cancer cell biology develops these classifications are updated. The purpose of classification

National Cancer Institute (2,886 words) [view diff] exact match in snippet view article find links to article

Biology DCB oversees approximately 2000 grants per year in the areas of cancer cell biology; cancer immunology, hematology, and etiology; DNA and chromosome

TACSTD2 (1,362 words) [view diff] exact match in snippet view article find links to article

deregulations at a transcriptional and posttranscriptional level. Trop-2 causes cancer cell growth, proliferation, invasion, migration, and survival of cancer cells

ERGIC2 (888 words) [view diff] exact match in snippet view article find links to article

formation in soft agar, and to decrease invasive potential of human prostate cancer cell line (PC-3 cells). It is now believed to be a chaperon molecule involved

Mir-16 microRNA precursor family (2,695 words) [view diff] case mismatch in snippet view article find links to article

Vecchione A (2008). "MicroRNA signatures in human ovarian cancer". Cancer Cell. 13 (3): 272–286. doi:10.1016/j.ccr.2008.02.013. PMID 18328430. Yanaihara

PAC-1 (1,787 words) [view diff] exact match in snippet view article find links to article

sensitizes these cells to PAC-1-type compounds. Recent experiments using cancer cell lines with CRISPR deletion of CASP3 are also consistent with this result

RPN2 (1,248 words) [view diff] exact match in snippet view article find links to article

"Role of ribophorin II in the response to anticancer drugs in gastric cancer cell lines". Oncology Letters. 9 (4): 1861–1868. doi:10.3892/ol.2015.2900

Pomiferin (921 words) [view diff] exact match in snippet view article find links to article

antimicrobial, antidiabetic, PDE5 inhibitor, and cytotoxicity for several cancer cell lines. Peterson and Fristad (2000) investigated folklore beliefs stating

CST7 (gene) (865 words) [view diff] exact match in snippet view article

system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. GRCh38: Ensembl release 89:

Frizzled-8 (658 words) [view diff] exact match in snippet view article find links to article

canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer

Ras GTPase (4,042 words) [view diff] exact match in snippet view article find links to article

acid (FTS, Salirasib) exhibits profound anti-oncogenic effects in many cancer cell lines. Inappropriate activation of the gene has been shown to play a

Integrin beta 6 (4,724 words) [view diff] exact match in snippet view article find links to article

cancers with pharmaceuticals and functional imaging agents, such as cancer cell specific positron emission tomography (PET) imaging using the αvβ6-integrin

Cylindrocyclophanes (1,067 words) [view diff] exact match in snippet view article find links to article

intriguing biological possibilities, especially its cytotoxicity to some cancer cell lines. Before the cylindrocyclophanes, the cyclophanes had all been produced

Small nucleolar RNA SNORD93 (439 words) [view diff] exact match in snippet view article find links to article

snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion". npj Breast Cancer. 3: 25. doi:10.1038/s41523-017-0032-8. PMC 5503938

ABCB5 (1,864 words) [view diff] exact match in snippet view article find links to article

further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts

Antimetabolite (1,239 words) [view diff] exact match in snippet view article find links to article

antimetabolites have high cell cycle specificity and can target arrest of cancer cell DNA replication. Anthracyclines are anti-tumor antibiotics that interfere

Fenbendazole (761 words) [view diff] exact match in snippet view article find links to article

"Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways". Scientific Reports.

Josef A. Käs (265 words) [view diff] exact match in snippet view article find links to article

recently (updated in the year of 2023), he has significantly contributed to cancer cell unjamming. Josef Alfons Käs studied at the Technische Universität München

Protease-activated receptor 2 (2,715 words) [view diff] exact match in snippet view article find links to article

KC, Xu W, Suen JY, Fairlie DP (November 2020). "PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR"

Mir-221 microRNA (2,794 words) [view diff] exact match in snippet view article find links to article

role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines". Cancer Res. 69 (8): 3356–63. doi:10.1158/0008-5472.CAN-08-4112

Anna Perdrix Rosell (435 words) [view diff] exact match in snippet view article find links to article

Perdrix Rosell is a Spanish scientist who completed her PhD[when?] in cancer cell signalling at the Francis Crick Institute in London. She co-founded a

Pan-cancer analysis (1,144 words) [view diff] exact match in snippet view article find links to article

RBPs—NSUN6, ZC3H13, BYSL, ELAC1, RBMS3, and ZGPAT—in colorectal and liver cancer cell lines. Several studies have found a causal, predictable connection between

SLC12A7 (451 words) [view diff] exact match in snippet view article find links to article

cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210

Pralatrexate (634 words) [view diff] case mismatch in snippet view article find links to article

Therapeutics' Pralatrexate Demonstrates Anticancer Activity in Multiple Cancer Cell Lines". [1], Memorial Sloan Kettering Cancer Center Press Release, "FDA

Radioligand (4,347 words) [view diff] exact match in snippet view article find links to article

is the target binding site, it may be on the surface of the targeted cancer cell for therapeutic purposes. Radioisotopes can occur naturally or be synthesized

Hydrazone (1,190 words) [view diff] exact match in snippet view article find links to article

targeted antibodies (see ADC), e.g. antibodies against a certain type of cancer cell. The hydrazone-based bond is stable at neutral pH (in the blood), but

Glypican (2,445 words) [view diff] exact match in snippet view article find links to article

expression can be detected in normal ovarian cells; however, several ovarian cancer cell lines do not express GPC3. On the other hand, GPC3 expression is undetectable

Midostaurin (613 words) [view diff] case mismatch in snippet view article find links to article

leukemia cells by the small molecule tyrosine kinase inhibitor PKC412". Cancer Cell. 1 (5): 433–43. doi:10.1016/S1535-6108(02)00069-7. PMID 12124173.{{cite

Pascal Mayer (815 words) [view diff] exact match in snippet view article find links to article

on cell lines, specific to cancer cells (no measurable effect on non-cancer cell lines), experiments carried out with EPFL. antibacterials based on IFRA

Glypican (2,445 words) [view diff] exact match in snippet view article find links to article

expression can be detected in normal ovarian cells; however, several ovarian cancer cell lines do not express GPC3. On the other hand, GPC3 expression is undetectable

Transcription factor Jun (5,537 words) [view diff] case mismatch in snippet view article find links to article

et al. (May 2007). "Rewired ERK-JNK signaling pathways in melanoma". Cancer Cell. 11 (5): 447–60. doi:10.1016/j.ccr.2007.03.009. PMC 1978100. PMID 17482134

ATP-dependent Clp protease proteolytic subunit (1,548 words) [view diff] exact match in snippet view article find links to article

agents, including by the hyperactivation of ClpP to cause selective cancer cell lethality. Intracellular proteases have a role in bacterial virulence

Hydrazone (1,190 words) [view diff] exact match in snippet view article find links to article

targeted antibodies (see ADC), e.g. antibodies against a certain type of cancer cell. The hydrazone-based bond is stable at neutral pH (in the blood), but

MMP11 (907 words) [view diff] exact match in snippet view article find links to article

S2CID 4266100. Boulay A, Masson R, Chenard MP, et al. (2001). "High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3

Palbociclib (3,588 words) [view diff] exact match in snippet view article find links to article

inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro". Breast Cancer Research. 11 (5): R77. doi:10.1186/bcr2419

Solasonine (534 words) [view diff] exact match in snippet view article find links to article

mitochondrial membrane permeability. Ferroptosis, a process that promotes cancer cell death, can be activated with solasonine by increasing and catalyzing

UK Coronavirus Cancer Monitoring Project (4,522 words) [view diff] case mismatch in snippet view article find links to article

line protective measure for UK chemotherapy centres” Published report: Cancer Cell Dec 2020-July 2021, Paediatric cancer patients Headline findings: “children

Catumaxomab (887 words) [view diff] exact match in snippet view article find links to article

dendritic cell via the heavy chains, an immunological reaction against the cancer cell is triggered. Removing cancer cells from the abdominal cavity reduces

KCNJ9 (658 words) [view diff] exact match in snippet view article find links to article

of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer. 5: 104. doi:10.1186/1471-2407-5-104. PMC 1208863

Latrophilin 2 (576 words) [view diff] exact match in snippet view article find links to article

expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Emactuzumab (697 words) [view diff] case mismatch in snippet view article find links to article

macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy". Cancer Cell. 25 (6): 846–859. doi:10.1016/j.ccr.2014.05.016. PMID 24898549. Ries

Mouse mammary tumor virus (2,047 words) [view diff] exact match in snippet view article find links to article

distinct from endogenous retroviruses and are not detectable in breast cancer cell lines or biopsies". Virology. 318 (1): 393–404. doi:10.1016/j.virol.2003

Major vault protein (1,419 words) [view diff] exact match in snippet view article find links to article

"Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–1310. doi:10.1083/jcb.141

Genetic marker (985 words) [view diff] no match in snippet view article find links to article

Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87. Gomez-Raya L, Olsen HG, Lingaas F, Klungland

Gammaretrovirus (2,347 words) [view diff] exact match in snippet view article find links to article

caused a controversy and eventual retraction. There were over 50 human cancer cell lines that were claimed to be linked to murine leukemia virus-related

OLIG2 (3,206 words) [view diff] case mismatch in snippet view article find links to article

responses to genotoxic damage in neural progenitors and malignant glioma". Cancer Cell. 19 (3): 359–71. doi:10.1016/j.ccr.2011.01.035. PMC 3070398. PMID 21397859

Ironomycin (599 words) [view diff] exact match in snippet view article find links to article

treatment of cancer. Ironomycin was shown to induce ferroptosis in breast cancer cell lines and its mechanism of action involves the targeting of lysosomal

ARHGAP5 (813 words) [view diff] exact match in snippet view article find links to article

the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion". Oncogene. 19 (10): 1318–28. doi:10.1038/sj.onc.1203422. PMID 10713673

GTP cyclohydrolase I (609 words) [view diff] exact match in snippet view article find links to article

potent, diffusable antioxidant that resists oxidative stress and enables cancer cell survival. Guanosine triphosphate (GTP) Tetrahydrobiopterin (THB, BH4)

Galangin (464 words) [view diff] exact match in snippet view article find links to article

F.; Moussa, M.; Carroll, K. K. (1996). "Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus

SDHB (2,957 words) [view diff] case mismatch in snippet view article find links to article

dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase". Cancer Cell. 7 (1): 77–85. doi:10.1016/j.ccr.2004.11.022. PMID 15652751. MacKenzie

MiR-203 (3,006 words) [view diff] exact match in snippet view article find links to article

where miR-203 is epigenetically silenced by hypermethylation. In lung cancer cell lines, miR-203 has been shown to target DKK1, a secreted protein which

Simarouba glauca (517 words) [view diff] exact match in snippet view article find links to article

mechanisms leading to cancer cell death.[citation needed] Simarouba extracts are known to be effective only on specific types of human cancer cell lines and tests

Plicamycin (484 words) [view diff] exact match in snippet view article find links to article

Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor. One elucidated pathway shows

Hereditary leiomyomatosis and renal cell cancer syndrome (2,010 words) [view diff] case mismatch in snippet view article find links to article

between hereditary and sporadic type 2 papillary renal cell carcinoma". Cancer Cell. 20 (4): 511–523. doi:10.1016/j.ccr.2011.08.024. PMID 22014576. Yogev

Discovery and development of proton pump inhibitors (4,990 words) [view diff] exact match in snippet view article find links to article

occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance. Evidence emerged

Lonaprisan (193 words) [view diff] exact match in snippet view article find links to article

J, Haendler B (2011). "The antiprogestin Lonaprisan inhibits breast cancer cell proliferation by inducing p21 expression". Mol. Cell. Endocrinol. 333

DNAJB4 (489 words) [view diff] exact match in snippet view article find links to article

upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi:10.1038/sj.onc.1208573. PMID 15782117

Navy bean (932 words) [view diff] exact match in snippet view article find links to article

antibacterial and anti-fungal activity, and have been found to inhibit cancer cell growth. Furthermore, navy beans are the richest source of ferulic acid

Cladosporium oxysporum (2,291 words) [view diff] exact match in snippet view article find links to article

T47D human breast cancer cell line, which suggested that the extract may exert its anti-proliferative effect on human breast cancer cell line by suppressing

CRABP1 (1,447 words) [view diff] exact match in snippet view article find links to article

maze test and an object recognition task. CRABP1 is also involved in cancer cell apoptosis. trans-retinoic acid was considered a [null therapeutic target

MDC1 (3,123 words) [view diff] exact match in snippet view article find links to article

Ser-15 residues necessary to p53 apoptotic activity. Studies on lung cancer cell lines (A549 cells) showed an increase in apoptosis in response to genotoxic

Cadherin-1 (6,381 words) [view diff] exact match in snippet view article find links to article

found that EMT can happen in breast cancer cell lines with hypermethylation of CDH1 promoter, but in breast cancer cell lines with a CDH1 mutational inactivation

FOXP3 (3,448 words) [view diff] exact match in snippet view article find links to article

Foxp3 in melanoma,[citation needed] glioma, breast, prostate and ovarian cancer cell lines induces profound growth inhibitory effects in vitro and in vivo

Michel Sadelain (2,618 words) [view diff] case mismatch in snippet view article find links to article

serves as the Director of Columbia University Irving Medical Center’s Cancer Cell Therapy Initiative in the Herbert Irving Comprehensive Cancer Center

Α-Hydroxyglutaric acid (764 words) [view diff] case mismatch in snippet view article find links to article

enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate". Cancer Cell. 17 (3): 225–34. doi:10.1016/j.ccr.2010.01.020. PMC 2849316. PMID 20171147

Portentol (400 words) [view diff] exact match in snippet view article find links to article

various other lichen. It has exhibited moderate activity toward several cancer cell lines. Of greater interest is the structural skeleton and chemical space

Fish hydrolysate (595 words) [view diff] exact match in snippet view article find links to article

'Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines', Process Biochemistry. Vol. 41, no. 5, May 2006. Brian Baker,

Aurora kinase A (2,712 words) [view diff] exact match in snippet view article find links to article

BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines". Oncogene. 14 (18): 2195–2200. doi:10.1038/sj.onc.1201065. PMID 9174055

Reverse transfection (961 words) [view diff] case mismatch in snippet view article find links to article

of live human cells". Nature Methods. 3 (5): 385–390. doi:10.1038/nmeth876. ISSN 1548-7091. Cancer Cell Lines and Primary Cells Retrieved 2011-10-14.

Nobiletin (386 words) [view diff] no match in snippet view article find links to article

efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell death & disease. 2022 Apr 19;13(4):374. Nobiletin[usurped], phytochemicals

Chromatin remodeling (5,523 words) [view diff] exact match in snippet view article find links to article

ATPase in cancer. Mutations in this gene were first recognized in human cancer cell lines derived from lung. In cancer, mutations in BRG1 show an unusually

Cancer-associated fibroblast (3,599 words) [view diff] exact match in snippet view article find links to article

angiogenesis, supporting the formation of tumours and thus proliferation of cancer cell and metastasis. Cancer cells are usually also drug resistant, which is

MMP15 (945 words) [view diff] exact match in snippet view article find links to article

1002/art.20313. PMID 15248212. Hotary K, Li XY, Allen E, et al. (2006). "A cancer cell metalloprotease triad regulates the basement membrane transmigration

Hedgehog signaling pathway (6,910 words) [view diff] case mismatch in snippet view article find links to article

antifungal that inhibits Hedgehog pathway activity and cancer growth". Cancer Cell. 17 (4): 388–399. doi:10.1016/j.ccr.2010.02.027. PMC 4039177. PMID 20385363

Acanthamoeba (2,845 words) [view diff] exact match in snippet view article find links to article

extensively to understand the molecular biology of cell motility and cancer cell dormancy by in-depth exploration of the process of encystation. The recently

Punicic acid (300 words) [view diff] exact match in snippet view article find links to article

chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel". Invest New Drugs. 23 (2): 121–2. doi:10

GDF11 (3,980 words) [view diff] exact match in snippet view article find links to article

and TNBC. GDF11 is also capable of inducing apoptosis in pancreatic cancer cell lines. However, In 130 patients with colorectal cancer (CRC), the expression

Crystal Mackall (3,269 words) [view diff] case mismatch in snippet view article find links to article

University. She is the founding director of the Stanford Center for Cancer Cell Therapy. Mackall grew up in East Palestine, Ohio in a working-class family;

CaBIG (2,648 words) [view diff] exact match in snippet view article find links to article

caBIG technology. In 2008, GlaxoSmithKline announced it would share cancer cell genomic data with caBIG. Some private companies claimed benefits from

UBE1L (662 words) [view diff] exact match in snippet view article find links to article

et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(2

Cell-mediated immunity (1,377 words) [view diff] exact match in snippet view article find links to article

Immunofluorescence micrograph of three cytotoxic T cells (outer three) surrounding a cancer cell. Lytic granules (red) are secreted at the contact site, killing the target

Homogeneity and heterogeneity (1,515 words) [view diff] exact match in snippet view article find links to article

terms, by varying or different genes or alleles. In cancer research, cancer cell heterogeneity is thought to be one of the underlying reasons that make

Institute of Cancer Research (2,950 words) [view diff] exact match in snippet view article find links to article

significance in cancer research since cell motility is a key feature of cancer cell behaviour during metastasis (the spread of tumours around the human body)

MSMB (2,098 words) [view diff] exact match in snippet view article find links to article

Pienta KJ (1993). "Effect of prostatic inhibin peptide (PIP) on prostate cancer cell growth in vitro and in vivo". Prostate. 22 (3): 225–33. doi:10.1002/pros

Euphorbiaceae (1,715 words) [view diff] exact match in snippet view article find links to article

bioactivity of euphol has shown concentration-dependent cytotoxic effects on cancer cell lines, with more than a five-fold difference in the IC50 values in some

INH1 (139 words) [view diff] exact match in snippet view article find links to article

consequently cancer cell apoptosis. Experiments show that INH1 potently inhibits the proliferation of multiple human breast cancer cell lines, cervical

Mothers against decapentaplegic homolog 7 (2,851 words) [view diff] exact match in snippet view article find links to article

JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line". Cell. Signal. 21 (6): 892–8. doi:10.1016/j.cellsig.2009.01.034

ERCC1 (5,503 words) [view diff] exact match in snippet view article find links to article

repress translation or trigger degradation of target RNAs.) In breast cancer cell lines, almost one third (55/167) of miRNA promoters were targets for

Tumor metabolome (2,581 words) [view diff] exact match in snippet view article find links to article

progression of a tumor. In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed

ABHD6 (413 words) [view diff] exact match in snippet view article find links to article

alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Molecular Biology Reports. 36 (4): 691–6. doi:10.1007/s11033-008-9230-7

Glutaminolysis (1,516 words) [view diff] exact match in snippet view article find links to article

"Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines". Cancer Research. 54 (22): 5974–5980. PMID 7954430. Spittler,

FreeLife (932 words) [view diff] exact match in snippet view article find links to article

were unfounded and based only on preliminary laboratory research on cancer cell inhibition, a finding that was never confirmed in other laboratory or

O-GlcNAc (14,334 words) [view diff] exact match in snippet view article find links to article

treat Parkinson's disease. Dysregulation of O-GlcNAc is associated with cancer cell proliferation and tumor growth. O-GlcNAcylation of the glycolytic enzyme

Tetrahydrobiopterin (2,818 words) [view diff] exact match in snippet view article find links to article

potent, diffusable antioxidant that resists oxidative stress and enables cancer cell survival via promotion of angiogenesis. "Sapropterin (Kuvan) Use During

MSH2 (4,237 words) [view diff] no match in snippet view article find links to article

deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer". Cell. 82 (2): 321–30. doi:10.1016/0092-8674(95)90319-4. PMID 7628020. S2CID 7954019

DNMT3B (1,443 words) [view diff] exact match in snippet view article find links to article

(August 2002). "An essential role for DNA methyltransferase DNMT3B in cancer cell survival". The Journal of Biological Chemistry. 277 (31): 28176–81. doi:10

Zinc transporter ZIP6 (535 words) [view diff] exact match in snippet view article find links to article

oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0

Colon cancer associated transcript 1 (658 words) [view diff] exact match in snippet view article find links to article

promotes tumor formation and is upregulated in colon cancer and other cancer cell types. This transcript may regulate long range chromosomal interactions

Byssus (1,619 words) [view diff] exact match in snippet view article find links to article

"Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy". Nanomedicine. 8 (1): 17–28

Estrogen receptor beta (4,526 words) [view diff] exact match in snippet view article find links to article

signaling has proliferative effects in both normal breast and breast cancer cell lines, whereas ERβ has generally antiproliferative effects in such cell

Bcl-xL (884 words) [view diff] exact match in snippet view article find links to article

from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line". BMC Cancer. 6 (213): 213. doi:10.1186/1471-2407-6-213. PMC 1560389

Magnetic nanoring (1,586 words) [view diff] exact match in snippet view article find links to article

body, as well as a clearer image of tumors by improving accuracy of cancer cell identification. They also allow for a more efficient and smaller, MRAM

BCAR3 (943 words) [view diff] exact match in snippet view article find links to article

anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". J. Cell. Physiol. 212 (3): 655–65. doi:10.1002/jcp.21059

Tetrandrine (761 words) [view diff] exact match in snippet view article find links to article

anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402". Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal

Mir-31 (1,275 words) [view diff] exact match in snippet view article find links to article

factor p53, responsible for encoding the tumour suppressor protein p53. Cancer cell lines with an inactive p53 pathway show a vulnerability to miR-31 overexpression

Oncogenomics (7,684 words) [view diff] exact match in snippet view article find links to article

tumor cells. Research has used mitochondrial mutations as biomarkers for cancer cell therapy. It is easier to target mutation within mitochondrial DNA versus

KMT2C (958 words) [view diff] exact match in snippet view article find links to article

"Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation". British Journal

Carmofur (837 words) [view diff] exact match in snippet view article find links to article

a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor

SULF1 (6,584 words) [view diff] exact match in snippet view article find links to article

specifically required for cisplatin-induced apoptosis of the ovarian cancer cell line, OV207. The mechanism by which Sulf1 is downregulated in ovarian

KLF4 (6,849 words) [view diff] exact match in snippet view article find links to article

(May 2003). "Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity". Oncogene. 22 (22): 3424–30

Susmita Bose (1,322 words) [view diff] exact match in snippet view article find links to article

developed ways to deliver curcumin and other natural compounds to stop bone cancer cell growth without inhibiting healthy bone cells. That same year, she was

TRPM8 (3,254 words) [view diff] exact match in snippet view article find links to article

in many prostate cancer cell lines and Dendreon/Genentech are pursuing an agonist approach to induce apoptosis and prostate cancer cell death. TRPM8 channels

Mir-10 microRNA precursor family (3,499 words) [view diff] no match in snippet view article find links to article

PMID 17355992. Lund AH (February 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58.

HIC1 (900 words) [view diff] case mismatch in snippet view article find links to article

loss of Hic1 function accentuates the role of p53 in tumorigenesis". Cancer Cell. 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761. Britschgi

TOX3 (767 words) [view diff] exact match in snippet view article find links to article

Chen W, Qin H, Diao W, Li B, Cao W, et al. (May 2019). "TOX3 inhibits cancer cell migration and invasion via transcriptional regulation of SNAI1 and SNAI2

KLF4 (6,849 words) [view diff] exact match in snippet view article find links to article

(May 2003). "Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity". Oncogene. 22 (22): 3424–30

Bruce Ponder (2,405 words) [view diff] exact match in snippet view article find links to article

showed that a cancer mutation could confer an advantage, so that a future cancer cell would outcompete surrounding normal cells, and moreover that this advantage

Laura Machesky (446 words) [view diff] exact match in snippet view article find links to article

Professor of Biochemistry. Machesky's research group specialises in cancer cell migration, invasion, metastasis and the energetics of cell biology. She

Prenylflavonoid (1,010 words) [view diff] exact match in snippet view article find links to article

effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines". Food and Chemical Toxicology. 37 (4): 271–85. doi:10.1016/S0278-6915(99)00019-8

Hypericum adenotrichum (221 words) [view diff] exact match in snippet view article find links to article

into for its anti-cancer properties, including slowing the growth of cancer cell lines. "Hypericum adenotrichum Spach". ipni.org. International Plant

PKM2 (4,865 words) [view diff] exact match in snippet view article find links to article

phosphate donor. Many of these proteins contribute to the regulation of cancer cell proliferation. Specifically, PKM2 can be a component in mitogen-activated

Initiation factor (1,418 words) [view diff] exact match in snippet view article find links to article

that are usually limited in translation and only proteins needed for cancer cell growth will be synthesized. This includes proteins involved in growth

CMP-sialic acid transporter (642 words) [view diff] exact match in snippet view article find links to article

"Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110)". Biochem. Biophys

Bombesin (723 words) [view diff] exact match in snippet view article find links to article

cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines". Scandinavian Journal of Gastroenterology. 34 (12): 1224–9. doi:10

Cynaropicrin (2,769 words) [view diff] exact match in snippet view article find links to article

kinase (ERK). Research shows that it had a pro-apoptotic activity on cancer cell lines U937, Eol-1 and Jurkat T cells. Its cytotoxic activity was inhibited

Bioelectronics (1,474 words) [view diff] exact match in snippet view article find links to article

Bioelectronics could be used to develop new label-free methods for monitoring cancer cell invasion and drug resistance. For example, the electrical resistance

Citric acid cycle (6,095 words) [view diff] exact match in snippet view article find links to article

a terminal metabolite as isotope labelling experiments of colorectal cancer cell lines show that its conversion back to alpha-ketoglutarate is too low

CpG island hypermethylation (1,148 words) [view diff] exact match in snippet view article find links to article

considered as an incomplete scenario, despite the idea of the genome of the cancer cell undergoing a reduction of its 5-methylcytosine content when compared

IQGAP1 (3,922 words) [view diff] exact match in snippet view article find links to article

Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines and its over-expression and distinct membrane localisation is also

Ekpoma virus (738 words) [view diff] exact match in snippet view article find links to article

broad cellular tropism and the ability to infect a wide range of human cancer cell lines. Neither virus has been isolated, hindering research. EKV-1 and

Igor Stagljar (1,667 words) [view diff] exact match in snippet view article find links to article

Sciences in Split (Croatia). He is an expert in the field of proteomics, cancer cell signalling and COVID-19 serological testing.[citation needed] He received

Diallyl trisulfide (866 words) [view diff] exact match in snippet view article find links to article

appear to contribute to the apoptosis of cancer cells and a decrease in cancer cell proliferation. DATS can be metabolized by glutathione in red blood cells

Diketopiperazine (413 words) [view diff] exact match in snippet view article find links to article

methicillin-resistant Staphylococcus aureus (MRSA), in addition to four different human cancer cell lines in vitro. As antivirals, however, DPKs appear to have a poor outlook

Pachypodol (189 words) [view diff] exact match in snippet view article find links to article

leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro". Phytotherapy Research. 22 (12): 1684–1687. doi:10.1002/ptr

Complex lasso proteins (1,078 words) [view diff] exact match in snippet view article find links to article

The motif has also shown significant inhibitory activities against cancer cell invasion and migration. However, multiple cyclized isomers of the peptide

Fyn-related kinase (575 words) [view diff] exact match in snippet view article find links to article

PMC 139241. PMID 12477932. Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int

Quorum sensing (10,858 words) [view diff] exact match in snippet view article find links to article

host and pathogenic bacteria. Quorum sensing may also be useful for cancer cell communications. In addition to its function in biological systems, quorum

KLK11 (974 words) [view diff] exact match in snippet view article find links to article

"Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". Prostate. 49 (1): 72–8. doi:10.1002/pros.1119. PMID 11550212

Macroketone (136 words) [view diff] case mismatch in snippet view article find links to article

Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration". European Journal of Organic Chemistry. 2008 (11): 1953–1958

Weiping Zou (877 words) [view diff] case mismatch in snippet view article find links to article

and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell, doi:10.1016/j.ccell.2022.02.003(2022). Zhou, J. et al. 2021. The ubiquitin

CCR5 (7,900 words) [view diff] exact match in snippet view article find links to article

leronlimab have been shown to block lung metastasis of human breast cancer cell lines. In preclinical studies of immune competent mice CCR5 inhibitors

Pancreatic stellate cell (2,538 words) [view diff] exact match in snippet view article find links to article

cytokines, ECM and angiogenic responses in PaSCs, which in turn induce cancer cell proliferation. Matri-cellular proteins may therefore directly contribute

MTA1 (3,836 words) [view diff] exact match in snippet view article find links to article

as a differentially expressed gene in a highly metastatic rat breast cancer cell line. The role in MTA1 in chromatin remodeling was deduced due to the

Menerba (1,115 words) [view diff] exact match in snippet view article find links to article

proliferative genes, c-myc and cyclin D1, or stimulate MCF-7 breast cancer cell proliferation or tumor formation, demonstrating that it may be a viable

EMSY (732 words) [view diff] no match in snippet view article find links to article

2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.

WAY-200070 (465 words) [view diff] exact match in snippet view article find links to article

treatment with tamoxifen and estrogen receptor β agonists on human breast cancer cell lines". Arch. Gynecol. Obstet. 289 (1): 163–71. doi:10.1007/s00404-013-2977-7

Alpha-1D adrenergic receptor (1,214 words) [view diff] exact match in snippet view article find links to article

Kyprianou N, Benning CM (August 2000). "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via

Demethylase (3,087 words) [view diff] no match in snippet view article find links to article

subunit of the NuRD complex and targets the metastasis programs in breast cancer". Cell. 138 (4): 660–72. doi:10.1016/j.cell.2009.05.050. PMID 19703393. Ciccone

60S ribosomal protein L11 (1,160 words) [view diff] case mismatch in snippet view article find links to article

(2004). "Regulation of HDM2 activity by the ribosomal protein L11". Cancer Cell. 3 (6): 577–587. doi:10.1016/S1535-6108(03)00134-X. PMID 12842086. Odintsova

IGFBP6 (981 words) [view diff] exact match in snippet view article find links to article

SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer. 29A (11): 1578–84. doi:10

Who's Afraid of Peer Review? (2,207 words) [view diff] exact match in snippet view article find links to article

template is "Molecule X from lichen species Y inhibits the growth of cancer cell Z". He created a database of molecules, lichens, and cancer cells to

TSPAN13 (624 words) [view diff] exact match in snippet view article find links to article

novel and previously described cell membrane markers in human breast cancer cell lines and tumors". Clin. Cancer Res. 11 (12): 4357–64. doi:10.1158/1078-0432

Elesclomol (650 words) [view diff] exact match in snippet view article find links to article

Kepros J, Yang CY, Zhang M, et al. (August 2008). "Elesclomol induces cancer cell apoptosis through oxidative stress". Molecular Cancer Therapeutics. 7

KMT2D (3,946 words) [view diff] exact match in snippet view article find links to article

and TNFRSF14. Conversely, KMT2D deficiency in several breast and colon cancer cell lines leads to reduced proliferation. Increased KMT2D was shown to facilitate

LDOC1 (645 words) [view diff] exact match in snippet view article find links to article

The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated

Mitogen (1,727 words) [view diff] case mismatch in snippet view article find links to article

progression in the absence of pocket protein activity". December 2005, Cancer Cell, Vol. 8, pp. 455-466 Gemberling et al. "Nrg1 is an injury-induced cardiomyocyte

Alpha-7 nicotinic receptor (2,815 words) [view diff] exact match in snippet view article find links to article

to be involved in cancer progression. They have been shown to mediate cancer cell proliferation and metastasis. α7 receptors are also involved in angiogenic

Wound healing assay (1,531 words) [view diff] exact match in snippet view article find links to article

interactions with respect to cell migration. High-throughput screens for: Cancer cell migration genes Small molecules Drug discovery Rate of cell migration:

Free fatty acid receptor 1 (7,458 words) [view diff] exact match in snippet view article find links to article

of cultured cancer cells. These malignant behaviors include cultured cancer cell motility and proliferation which are regarded as being related to the