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Longer titles found: List of breast cancer cell lines (view), Cancer Cell (journal) (view), Cancer Cell International (view), RNAi-Based Identification System and interference of Specific Cancer Cells (view)

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MRC Cancer Unit (293 words) [view diff] case mismatch in snippet view article find links to article

Biomedical Campus. The MRC Cancer Unit was established in 2001 (as the MRC Cancer Cell Unit) by Professor Ron Laskey CBE, who was also appointed as the unit's

the growth of the ZR-75 and MCF-7 breast cancer cell lines. It was inactive in ER-negative breast cancer cell lines. In contrast to conventional antiestrogens

Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute

gene, resulting in the increase of p53 protein level and enhancement of cancer cell-apoptosis. p53 prevents the cell from replicating by stopping the cell

essential for cancer cell proliferation. However, recent research using CRISPR has demonstrated that MELK is fully dispensable for cancer cell growth, casting

cytoskeletal remodeling in cells during movement and migration, including cancer cell metastasis. G13 is also essential for receptor tyrosine kinase-induced

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. The microRNA miR-2185

The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds

cytotoxic agent MMAE, which is released after internalization by the cancer cell. In addition to its direct cytotoxic effect, sofituzumab vedotin may

to be 3- to 10-fold more potent than tamoxifen in inhibiting breast cancer cell growth in in vitro models. Miproxifene is the active metabolite of miproxifene

(EmaxTooltip maximal efficacy (relative to moxestrol, in Ishikawa endometrial cancer cell line) = 105%). The compound is a pyrrolo indolizine derivative. Its development

membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies, and when cells are infected with hepatitis C. The process of

found to be 3- to 10-fold as potent as tamoxifen in inhibiting breast cancer cell growth in in vitro models. It is a derivative of afimoxifene (4-hydroxytamoxifen)

so. Dauricine has been studied in vitro for its potential to inhibit cancer cell growth and to block cardiac transmembrane Na+, K+, and Ca2+ ion currents

cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth. ENSG00000282110

is an essential step for the metastatic progression of most cancers. Cancer cell invasion, ECM degradation, and metastasis are highly linked with the

transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. Lipocalin proteins are important key players of nutritional

and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80. doi:10.1038/onc

century, advances in genetics led to the discovery of over one hundred cancer cell types. Cancer cells were noted for their bewildering diversity. It was

for Network Biology, the San Diego Center for Systems Biology, and the Cancer Cell Map Initiative. He uses genome-scale measurements to construct network

mechanism for constitutive Wnt pathway activation in human cancer cells". Cancer Cell. 6 (5): 497–506. doi:10.1016/j.ccr.2004.09.032. PMID 15542433. Schlange

and TGF-β receptor 2 in a pancreatic cancer cell line. Overexpression of the miR-655 mimic in the Panc1 cancer cell line upregulated the expression of E-cadherin

acquired resistance after drug exposure, which is rooted in the concept of cancer cell heterogeneity. Characteristics of resistant cells include altered membrane

level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. GRCh38: Ensembl release

(DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research

pachyphylla). It has been studied in-vitro for anti-cancer effects in various cancer cell types. Carnosic acid List of phytochemicals in food Ai-Hsiang Lo; Yu-Chih

pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation. One synthetic method is based on Skraup

inhibitor. It also acts as a vasodilator and induces apoptosis in some cancer cell lines. 2-Methoxyestradiol is derived from estradiol, although it interacts

tissues, deregulation of cell motility is one of the hallmark events in cancer cell invasion and metastasis. Overexpression of a constitutively active Rac1

both a T-cell receptor and an antibody specific to a protein on the cancer cell, and transferred back to the person. The T cells are engineered to target

Attardi and Scott A. Armstrong. It is content is broadly focused on cancer cell biology, tumorigenesis and cancer progression, and translational cancer

Mumbai and Goa. He has also contributed to the establishment of Indian Cancer Cell, an educational program co-sponsored by Tata Memorial Centre, Union for

under the brand name Ralone in Spain. Although zeranol may increase cancer cell proliferation in already existing breast cancer, dietary exposure from

inhibit cancer cell proliferation. Although ROS can promote tumor cell proliferation, a great increase in ROS has been associated with reduced cancer cell proliferation

on the cancer cell surface that colocalize with the integrin receptors. The interaction between type IV collagen produced by the cancer cell, and integrins

receptor. A tumor suppressor would trigger an apoptotic pathway in a cancer cell if there were DNA damage, polyploidy, or uncontrolled cell growth. Simultaneously

epothilones A to F have been identified and characterized. Early studies in cancer cell lines and human cancer patients indicate superior efficacy to the taxanes

effects and therapeutic potentials. HAS2 is overexpressed in breast cancer cell lines and is associated with lymph node metastasis, while HAS1 and HAS3

MDA-MB-453 is a human breast cancer cell line. The MDA-MB-453 cell cancer line was derived in 1976 from the pericardial effusion of a 48-year-old female

the centre include the Australian Cancer Research Foundation (ACRF) Cancer Cell Biology Program and the ACRF Victorian Centre for Functional Genomics

been found for MUC4 using commercial mRNAs or total RNAs extracted from cancer cell lines. Some predicted forms are soluble, while others are membrane bound

T-47D is a human breast cancer cell line commonly used in biomedical research involving the hormonal expression of cancer cells. The cells were derived

their ability to invade through the extracellular matrix, especially in cancer cell extravasation. Invadopodia are generally visualized by the holes they

Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell. 113 (2): 207–19. doi:10.1016/S0092-8674(03)00234-4. PMID 12705869.

antigen, the physical structure of the T cell changes to destroy the cancer cell. This is a method of cancer treatment that works on the cellular and

metastatic sites. Cancer cell chemotaxis also relies on this migratory behavior to arrive at a secondary destination designated for cancer cell colonization

ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. However, in this same study, taxifolin

overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression

Hep G2 (or HepG2) is a human liver cancer cell line. Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old

MMP-27 was also identified, at the protein level, in MDA-MB-231 breast cancer cell line and in primary human breast cancer. Recently, MMP-27 has been demonstrated

peer-reviewed scientific journal published under the Springer Nature addressing cancer cell genetics and the structure and function of oncogenes. The journal has

should be used in using results for a cancer cell line to make predictions for healthy cells if the cancer cell line is known to be resistant to cytotoxic

supported by studies that cloned the receptor from the PC-3 prostate cancer cell line. The cloned receptor, when expressed in other cell types, bound

HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings. HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene

there are various pathways that can be targeted by compounds to prevent cancer cell proliferation. One such pathway is oxidative phosphorylation (OXPHOS)

kinase inhibitor and works by interfering with signalling within the cancer cell. Nilotinib was approved for medical use in the United States in 2007

centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative

precipitate mutations within an organism's genome, potentially culminating in cancer cell formation. Unrectified lesions may also interfere with polymerase function

PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. PC3 cells are useful in investigating biochemical

altering the co-stimulatory signal to help get the T-cell to recognize the cancer cell and become fully activated. Cancers that possess the B7-H3 immunoregulatory

also seen to be overexpressed in most ovarian, endometrial and breast cancer cell lines. The mechanism behind this is believed to be that ID4 regulates

miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than

which express MHC class-I A2 and A3. K562 cells are part of the NCI-60 cancer cell line panel used by the National Cancer Institute. Many factors and components

A growth curve is an empirical model of the evolution of a quantity over time. Growth curves are widely used in biology for quantities such as population

subjected to etc., Aberrant cell division takes place that ends up in a cancer cell and such aberrance may be due to faulty stem cell, abnormal genetic components

cell-based cancer vaccine) Obeid et al. investigated how inducing immunogenic cancer cell death ought to become a priority of cancer chemotherapy. He reasoned

miR-26a delivery using adeno-associated virus (AAV) is able to inhibit cancer cell formation while also inducing tumour-specific apoptosis and providing

with ARID1A loss driving pre-memory B cell fate and lymphomagenesis". Cancer Cell. 42 (4): 583–604.e11. doi:10.1016/j.ccell.2024.02.010. PMC 11407687.

concentrations on the order of 10−6 M. Two multidrug-resistant breast and ovarian cancer cell lines also showed sensitivity to the peptides. Further, peptide anticancer

under preliminary research for its potential to treat various forms of cancer. Cell-based immunotherapies are effective for some cancers. Immune effector

BT-20 is a breast cancer cell line derived from a 74-year-old human female in 1958 by E.Y. Lasfargues and L. Ozzello. The cells technically came from

from a normal to cancer genotype; or vice versa; in characterized human cancer cell lines such as HCT116 or Nalm6. There are several gene targeting technologies

response to environmental and internal stimuli, such as a model of a cancer cell in order to find weaknesses in its signalling pathways, or modelling

6-biphosphatase 4 as an important regulator of prostate cancer cell survival". Cancer Discovery. 2 (4): 328–43. doi:10.1158/2159-8290.CD-11-0234

also lower in three human cervical cancer cell lines (i.e., HeLa, abd, and CaSki cells) and a human uterus cancer cell line (i.e., SiHa cells) than normal

a donation by Jeffrey Rothschild established the Stanford Center for Cancer Cell Therapy, which supports research into the development of immunological

telomeres by adding bases to the ends and thus renewing the telomere. A cancer cell has in essence turned on the telomerase gene, and this allows them to

human cancer cells in an animal model of human melanoma; DCPIP-induced cancer cell death occurs by depletion of intracellular glutathione and upregulation

gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity

proliferation; and inhibit the growth and metastasis of human breast and prostate cancer cell lines. It is suggested that the EDP and EEQ metabolites function in humans

is a crucial early event in the development of lung adenocarcinoma". Cancer Cell. 24 (5): 603–616. doi:10.1016/j.ccr.2013.10.003. PMID 24229708. Lee JW

PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of ductal cell origin. PANC-1 was derived from the tissue of a 56-year-old

Baffa R, Croce CM (August 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18):

have found that four NOSH variants, evaluated in eleven different human cancer cell lines, were effective in inhibiting the growth of these cell lines. NOSH-1

Body JJ (1998). "Establishment and characterization of three new breast-cancer cell lines". International Journal of Cancer. 76 (5): 677–683. doi:10

studies in animal models have found it to be effective at preventing cancer cell resistance to chemotherapeutics, but these findings did not translate

MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development. In 1977, MIA PaCa-2 cells were

shows cytotoxicity to: The colon cancer cell line HCT-116 The lung cancer cell line NCI-H460 The breast cancer cell lines MCF-7 and ZR-75-1 The central

tumor promoter which has an anti-proliferative activity against various cancer cell lines in mice. The first reported case of seaweed dermatitis was from

proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells". Cancer Cell. 9 (6): 435–43. doi:10.1016/j.ccr.2006.04.020. PMID 16766263. Robertus

antibody–drug conjugate consists of three components: Antibody - targets the cancer cell surface and may also elicit a therapeutic response. Payload - elicits

culture dishes, where it can be propagated as an immortalized prostate cancer cell line. LAPC4 are a lowly adherent, epithelial cell line with high Androgen

Epifluorescent imaging of the three components in a dividing human cancer cell. DNA is stained blue, a protein called INCENP is green, and the microtubules

region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However

linked to its melanocyte-specific transcriptional regulation by MITF". Cancer Cell. 6 (6): 565–76. doi:10.1016/j.ccr.2004.10.014. PMID 15607961. Hoek KS

et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation

apoptosis. This is a result of lysosome membrane permeabilization promoting cancer cell death. Lysosomal membrane permeabilization is not activated by oleocanthal

and the human Fc portion has the ability to disrupt the heterotypic cancer cell adhesion mediated by the MUC16-mesothelin interaction. Mesothelin has

exportin 1 and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests

treatment depends on the location of the tumor, as well as the type of cancer cell and whether it has invaded other tissues or spread elsewhere. These factors

culture dishes, where it can be propagated as an immortalized prostate cancer cell line. VCaP are an adherent, epithelial cell line with high Androgen receptor

transformation. This work has contributed to the resurgent interest in cancer cell metabolism and may form the basis for translational therapies to exploit

production in cultured prostate cancer cell lines, have implicated 12-HETE (stereoisomer sometimes undefined) in cancer cell lines from various other human

S180 is a murine Sarcoma cancer cell line. It has been commonly used in cancer research due to its rapid growth and proliferation in mice. The cell line

Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013). "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters. 587 (14): 2105–11

HT-29 is a human colon cancer cell line used extensively in biological and cancer research. The HT-29 cell line was established in 1964 from the tumor

3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells". International

Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response

mutated in familial and sporadic schwannomas. Additionally, several human cancer cell lines invoke mutations of the SAV1 and MOBK1B proteins. However, recent

expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sciences. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6

Karin Dorinda Norlin Rodland (born 1949) is an American cancer cell biologist. She is a professor emeritus at Oregon Health and Science University. Rodland

inflammation and tumor biology. tTG expression is elevated in multiple cancer cell types and is implicated in drug resistance and metastasis due to its

SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers". Oncogene. 29

engraftment success. Unlike creating xenograft mouse models using existing cancer cell lines, there are no intermediate in vitro processing steps before implanting

and that some of the developmentally inaccessible cell types might be cancer cell types. This suggested the possibility of "cancer differentiation therapy"

labeling concentrations, it is widely preferred for in vivo studies of cancer cell proliferation. However, at radiosensitizing concentrations, BrdU becomes

humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created. The protein encoded by this gene

hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited

4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine

cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line". Cancer Cell Int. 11 (6): 6. doi:10.1186/1475-2867-11-6. PMC 3063814. PMID 21392380

bioassay measures estrogen-induced increase of the number of human breast cancer cell, which is biologically equivalent to the increase of mitotic activity

recombination between two mouse retroviruses during propagation of a prostate-cancer cell line in the mid-1990s. These findings raised serious questions concerning

nitric oxide (NO) is able to have a cytostatic effect on the human breast cancer cell line MDA-MB-231. Not only does nitric oxide stop cell growth, the study

structures, KRT81 expression has been observed in the SKBR3 human breast cancer cell line and metastatic lymph nodes of breast carcinomas, but not in normal

probability of survival. This down regulation was also observed in breast cancer cell lines, including MCF-7 and MDA-MB-231 compared to the non-malignant cell

presence of specific antibodies, and can kill primary leukemic cells, cancer cell lines, and cells infected with hepatitis B virus. In addition, CD16 is

or proliferation when it was downregulated. According to a study in Cancer Cell International, suppression of the HOXC6 gene plays a role in blocking

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. miR-624 has been found

therapy in the breast to inhibit breast cancer growth and induce breast cancer cell death. The antiestrogen withdrawal syndrome is analogous to but less

BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof. BxPC-3 cells were derived

"N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity". Cancer Cell. 19 (2): 218–231. doi:10.1016/j

nervous system. The main steps involved in the metastatic cascade of a cancer cell are: Cell division and growth within the primary tumor Invasion of the

implicated in the metastatic process by modulating vascular permeability, cancer cell motility and invasiveness. The former name, FIAF, stands for Fasting-Induced

scientist primarily known for her establishment of a series of breast cancer cell lines that have been crucial to the discovery of anticancer drugs and

17-hydroxy-HDHA, have been shown to inhibit the growth of cultured human prostate cancer cell by causing them to enter apoptosis. Studies on rodents lacking or made

has shown to be effective in blocking cell cycle progression of lung cancer cell lines. Moreover, this combination treatment reduces angiogenesis. This

the characterization and identification of the DNA or RNA sequences of cancer cell(s). Unlike whole genome (WG) sequencing which is typically from blood

affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794. Di

"DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". The Journal of Biological Chemistry. 277 (39): 35795–35800. doi:10

ZR-75-1 is a human breast cancer cell line. Darbre PD, Daly RJ (December 1990). "Transition of human breast cancer cells from an oestrogen responsive

pluripotency in embryonic cells but also has the ability to regulate cancer cell proliferation and can be found in various cancers such as pancreatic

Zhang GH, Xu XC, Zhang N (July 2011). "miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met". Cancer

that LARP4 is involved in mRNA stability. LARP4 is known to regulate cancer cell migration and invasion by altering cell shape. It is also reported to

glycoprotein is a normal part of human tissue but may be overexpressed on some cancer cell types. MV-NIS is the first targeted engineered virus therapy to have

protein required for estrogen-dependent gene transcription and breast cancer cell growth. The ARGLU1 gene expresses at least three distinct RNA splice

increase EDP levels in and inhibit the growth of several human renal cancer cell lines in vitro and 2) dietary DHA likewise acted synergistically with

triterpene molecules with notable cytotoxic activity towards certain cancer cell lines. Swee Cheng Lim; Nicole de Voogd; Koh Siang Tan (2008). A guide

expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein

euglonophycin was demonstrated in leukemia, neuroblastoma, and colorectal cancer cell lines. Specifically, in colorectal cancer cells, euglenophycin exposure

properties. It has displayed various inhibitory properties towards multiple cancer cell lines that include, lymphoma, carcinoma, multiple myeloma, melanoma,

These act to accelerate the proteolysis of the p27 protein and allow the cancer cell to undergo rapid division and uncontrolled proliferation. When p27 is

(also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with

protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted

and the myeloma partner has traits that make it immortal (similar to a cancer cell).[citation needed] This mixture of cells is then diluted and clones are

and tested for its anticancer activity. Pht-GNPs showed significant cancer cell toxicities compared to free phloretin. Phlorizin is the 2'-glucoside

upregulation of MRN complex sub-units has been documented in certain cancer cell lines when compared to non-malignant somatic cells, suggesting some cancer

carcinoma, cell line UPCI-SCC-103. A: The cancer cell treated with antibodies against tubulin. B: The same cancer cell stained with DAPI, highlighting the nuclei

arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate. 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743

carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small-cell lung. Synonyms:

Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory

from stress and damage. In 2024, a study demonstrated 4-OHE1's role in cancer cell survival and its potential therapeutics for breast cancer treatment.

the aberrant regulation of miR-129 contributes to the proliferation of cancer cell lines. SOX4 is involved in the mediation of transcription response to

accomplishments include the development of a genome capable of controlling cancer cell proliferation and the identification of a neuropeptide Y-based growth

it has shown inhibitory properties against endometrial and ovarian cancer cell lines. Enslin, P. R. (1954). "Bitter principles of the cucurbitaceae

it has shown inhibitory properties against endometrial and ovarian cancer cell lines. Enslin, P. R. (1954). "Bitter principles of the cucurbitaceae

ATPase in cancer. Mutations in this gene were first recognized in human cancer cell lines derived from adrenal gland and lung. Later it was recognized that

RM, Calin GA (2010). "MYC-microRNA-9-metastasis connection in breast cancer". Cell Res. 20 (6): 603–4. doi:10.1038/cr.2010.70. hdl:1822/67519. PMID 20502442

ErbB signaling from the structure of the ErbB2-pertuzumab complex". Cancer Cell. 5 (4): 317–328. doi:10.1016/S1535-6108(04)00083-2. PMID 15093539. Bouyain

cancer secretomics are cancer cell line supernatants and proximal biological fluids, the fluids in contact with a tumor. Cancer cell line supernatant is

colonization at distant tissues. In a series of mouse mammary isogenic cancer cell lines, the miR-200 family is highly expressed only in the cells that

also prevents the interaction of immune cells with receptors on the cancer cell surface through steric hindrance. This inhibits an anti-tumor immune

yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro, including a multidrug-resistant KB line. Cruentaren B

these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ultimately tumor shrinkage. In the early 1990s, Ullrich and

range of cancers, and alterations of the gene are frequently seen in cancer cell lines. Examples include: Pancreatic adenocarcinoma is often associated

the prevalence is less than 5% in normal cell lines, but 15-100% in cancer cell lines. The PNC is directly proportional to metastasis as well as linked

cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the

research center in the U.S. He is also the co-director of the Program in Cancer Cell Biology & Signaling at the Sidney Kimmel Cancer Center, Thomas Jefferson

myelogenous leukemia (CML) cell line used for biomedical research. Like all cancer cell lines, it is immortal and can divide indefinitely. A unique aspect of

Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer". Cell Reports. 13 (5): 1046–1058. doi:10.1016/j.celrep.2015.09.063. PMC 4806384

CpG island on its promoter region, promoting the suppression of the cancer cell apoptosis. Furthermore, activity of lncPVT1 and its associated microRNAs

Cdk2 and Cdk4. The effects of U0126 on the growth of eight human breast cancer cell lines shown that U0126 selectively repressed anchorage-independent growth

tumors. DACH1 inhibits Cyclin D1 expression and thereby reduces breast cancer cell line cell growth. Normal cells and some breast cancer cells have receptors

attachment to endothelial cells as well. Knocking down β1 integrin inhibited cancer cell migration, whereas overexpressing the integrin in Cdc42-deficient cells

dysregulation on cells and organs. STAU1 dysregulation may play a role in cancer cell development and progression. STAU1 has been associated with maintaining

discovered that artemisinin targets a broad spectrum of proteins in the human cancer cell proteome through heme-activated radical alkylation. Dihydroartemisinin

Yao Q, Chen C (April 2009). "Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis". World Journal

tetrandra. It has in vitro antiproliferative activity against a breast cancer cell line. Xie, Zhisheng; Xu, Xinjun; Xie, Chunyan; Liang, Zhikun; Yang, Mei;

"Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines". Jpn. J. Cancer Res. 93 (8): 857–60. doi:10.1111/j.1349-7006.2002

in biorepositories can be used for biomarker analysis as colorectal cancer cell-derived exosomes spiked into blood plasma could be recovered after 90

a) modulating cell-matrix adhesion and migration, and b) inhibiting cancer cell growth. (Note: *HEPACAM, gene name; **hepaCAM, protein name) Through

and infections, as well as hepatic coma. The compound was tested on cancer cell lines, and it exhibited little toxicity on the normal cell line. https://datasheets

ACTIBIND Experiments in vitro Cancer Cell Colony Formation In order to determine the effects of ACTIBIND on cancer cell colony formation, a study done

along with MRCKα/β kinases have been implicated in the plasticity of cancer cell migration, the phenomenon which bestows survival advantage to the cancer

of human cancer tumors in vivo as well as in various types of human cancer cell lines in vitro; these tumors and cell lines include those of the pancreas

much more effective than an aqueous extract at causing MCF-7 breast cancer cell death and inhibiting further cell multiplication. As of February 2025[update]

derivatives piscarinines A and B were shown to be active against the prostate cancer cell line LNCAP (IC50 values were 2.2 and 1.9 μg/mL for piscarinine A and

alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". doi:10.1101/2020.09.04.282657. S2CID 221589215. {{cite journal}}:

performed in two breast cancer cell lines in mice which were phenotypically distinct. One of these was a stem-cell like breast cancer cell line that altered

and national scientific conferences. One focus of her research is on cancer cell biology, specifically in regards to the pHi (intracellular pH) of cancer

This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents

with colon and rectal cancers. MEKK3 is highly expressed in 4 ovarian cancer cell lines (OVCA429, Hey, DOV13, and SKOv3). This expression level is significantly

NADH into mitochondria to ensure a high rate of glycolysis in diverse cancer cell lines. In a study completed in 2008, inhibiting the malate-aspartate

Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated

of Pennsylvania Perelman School of Medicine. Her research focuses on cancer cell metabolism, angiogenesis, and immunology. Simon earned a B.A. from Miami

of Individual Metastases during HER2 Blockade in Colorectal Cancer". Cancer Cell. 34 (1): 148–162.e7. doi:10.1016/j.ccell.2018.06.004. ISSN 1878-3686

cancerous cells. Similarly, PDK3 has been shown to be overexpressed in colon cancer cell lines. Three proposed inhibitors are AZD7545 and dichloroacetate which

is reduced in gastric cancer. mir-126 expression is reduced in lung cancer cell lines. mir-126 expression is reduced in prostate cancer and bladder cancer

exhibits antiangiogenic activity, and has efficacy against several cancer cell lines. Its reported anticancer mechanism is that it acts as a farnesyl

inhibitory activity against human lung cancer cell line A549, colorectal cancer cell line HCT116, and breast cancer cell line MCF-7. An experimental drug was

natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 μg/mL, ranging from 3.5 (NEC)

(2006). "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes". Cancer Cell. 10 (6): 515–27. doi:10.1016/j.ccr

is reduced in gastric cancer. mir-126 expression is reduced in lung cancer cell lines. mir-126 expression is reduced in prostate cancer and bladder cancer

circadian clock may play a large role in its likelihood of developing into a cancer cell. PER1 is a gene that plays an important role in such a circadian mechanism

isolated from a Penicillium species that has in vitro activity in a cancer cell line. It was first discovered in fungal species which evolved to live

show that extracts of G. furcata inhibit the growth of several human cancer cell lines, and can significantly lower blood glucose levels. G. furcata's

of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Cancer Research. 57 (16): 3537–47. PMID 9270026. Suzuki T, Nishio

discovery, and the demonstration that the anti-sense of hTR could kill every cancer cell tested, Andrews and 3 members of his team were awarded second place for

University of Virginia School of Medicine. His work focused on understanding cancer cell signaling as a potential target for cancer therapies. Born in 1942 to

source of antibiofilm agents and to present selectivity against human cancer cell lines at low concentrations compared to normal cells. M. scutellaris

cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in

complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression Moreover, VGLL2 interaction

"U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line". PLOS Genet. 6 (1): e1000832. doi:10.1371/journal.pgen.1000832

activity can activate genes that cause cancer cell survival, and can also activate genes that facilitate cancer cell metastasis to other tissues. P38 was

interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC 1987708. PMID 17349584

In 1996, Welch's lab in Hershey, Pennsylvania, isolated a cDNA from a cancer cell that was not able to undergo metastasis after the human chromosome 6

Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell, 26: 605-22, 2014 Jain, RK. Normalizing tumor vasculature with anti-angiogenic

C-3 phthalates derivatives exhibited higher cytotoxic activity against cancer cell lines with improved selective toxicity and water solubility. Chatterjee

leronlimab have been shown to block lung metastasis of human breast cancer cell lines. In preclinical studies of immune competent mice CCR5 inhibitors

both in vitro and in vivo, and stimulates the growth of human breast cancer cell lines. It is a common metabolite of paraben esters, such as methylparaben

inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327

androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation. GRCh38: Ensembl

between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth". Oncotarget. 7 (14): 18295–308. doi:10

discovered mechanisms whereby senescence inducing therapies promote cancer cell immune surveillance. In 2015, Lowe continued his use of RNAi to study

Victoria Sanz Moreno is a Spanish scientist. She is professor of cancer cell and metastasis biology at The Institute of Cancer Research. Sanz-Moreno was

August 2017). "The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis". Scientific Reports. 7 (1): 8136. Bibcode:2017NatSR

oligonucleotides have been used to induce exon 4 skipping in prostate cancer cell lines, mouse models and tissue explants, leading to anti-cancer effects

of N-Myc is a critical function of Aurora A in human neuroblastoma". Cancer Cell. 15 (1): 67–78. doi:10.1016/j.ccr.2008.12.005. PMID 19111882. Gustafson

RHoGD12 is active in bladder cancer and inhibits proteins that aid in cancer cell migration. RhoGDI2 suppresses endothelin 1 (ET1), a vasoconstrictor correlated

DNA copy number profile for the T47D breast cancer cell line (Affymetrix SNP Array)

growth factor receptor overexpression in angiogenic endothelial cells". Cancer Cell. 14 (5): 382–93. doi:10.1016/j.ccr.2008.10.005. PMC 2597164. PMID 18977327

mutagenic DNA damages. A normal cell may undergo carcinogenesis to become a cancer cell if it is frequently subjected to DNA damage during long periods of chronic

effective DNA repair, which may prevent transformation of normal into a cancer cell (carcinogenesis), or to cell death, often by the mode of apoptosis. An

paper an in vitro protocol to test different light wavelengths on human cancer cell lines is developed, finding that blue light most effectively inhibited

complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression. The interaction between

(November 2007). "High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts

gov) Tamoxifen has a positive "Clinical Trial" relationship with breast cancer Cell Expression Expression of proteins within or on the surface of a cell

skin. KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian and

suggested that 5-oxo-ETE contributes to the development of inflammation, cancer cell growth, and other pathological and physiological events. In the most

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. Nasopharyngeal carcinoma-associated

invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4:437-450 (2003) Hingorani, S.R., Wang, L., Multani, A.S., Combs, C

in 1972 as "trabecular tumor of the skin". Based on its origin, the cancer cell type is called a neuroectodermal tumor. Although rare compared with other

pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. Nasopharyngeal carcinoma-associated

epithelial cells increases the concentration of sarcosine and increase cancer cell invasions while the removal of either dimethylglycine dehydrogenase or

multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Biological systems are known to be highly transparent to

that peroxiredoxin 3 is overexpressed in prostate cancer and promotes cancer cell survival by defending cells against the damages incurred by oxidative

significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3. There is

creating the first cancer cell line from the Caribbean in 2022 during the COVID-19 pandemic. The intent was to create more cancer cell lines for black people

pathways such as p53. Suppression of Kdm4a in breast cancer cell lines has shown to reduce cancer cell proliferation through cell cycle arrest, and decrease

publication in 2001 coining the term "cancer stem cell" to describe a cancer cell that mirrors the properties of stem cells of healthy organs in the context

(born 1946) is a New Zealand cell biologist. Since 1976, he has led the cancer cell and molecular biology research group at the Malaghan Institute of Medical

studies, it showed antiproliferative activity against various human cancer cell lines. Breitler, Simon; Carreira, Erick M. (2013). "Total Synthesis of

familial pheochromocytoma genes: developmental culling and cancer". Cancer Cell. 8 (2): 155–67. doi:10.1016/j.ccr.2005.06.015. PMID 16098468. Hopfer

Centre, Melbourne For new technologies to identify genes controlling cancer cell behaviour $2,500,000 QLD Institute for Molecular Bioscience, University

endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637

PMID 37922928. Alfarouk KO (December 2016). "Tumor metabolism, cancer cell transporters, and microenvironmental resistance". Journal of Enzyme Inhibition

implications in a number of disease conditions, exemplified by oncogenesis, cancer cell invasion and metastasis. PAK4 has been shown to interact with: CDC42

S2CID 1866233. Mitra R, Goodman OB (April 2015). "CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR". The Prostate. 75

S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNA interference results in re-replication

on the tricarboxylic acid cycle and inhibiting enzymes involved with cancer cell energy metabolism. A lipoic acid derivative different from standard cytotoxic

transferrin that would potentially attach to transferrin receptors on cancer cell surfaces. There is very high selectivity for transferrin receptors because

"Bakuchiol inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity". Tianjin

typically from the spleen. The antibody producing cell is then fused with a cancer cell line. This causes the antibodies to show specificity for a single epitope

apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2". Investigational New Drugs. 26 (2): 111–8. doi:10.1007/s10637-007-9087-y

loss of collagen XXIII may complicate cellular adhesion and reduce lung cancer cell retention. Collagen Protein domain Transmembrane protein Non-small-cell

diseases, association of CBP with β-catenin has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads

that targets cancer cells through multiple modes of action. It inhibits cancer cell growth by targeting the FGF receptor family, which are mutated in a number

K. (2015-04-09). "MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking

microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples". FEBS J. 277 (7): 1684–94. doi:10.1111/j

on a key role in metastasis of the tumor. However, in the 4T1 breast cancer cell line, E-selectin reactivity is sLe(x) dependent while P-selectin reactivity

angiogenesis. Studies analyzing SMAD3 levels of expression in prostate cancer cell lines found that the two androgen-independent and androgen receptor-negative

EpCAM in cancer tissue, where it is homogeneously distributed on the cancer cell surface. In addition to being overexpressed in many carcinomas, EpCAM

Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth". Cancer Cell. 17 (4): 388–99. doi:10.1016/j.ccr.2010.02.027. PMC 4039177. PMID 20385363

Keller ET (May 2001). "Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro" (PDF). Prostate. 47 (3): 212–21. doi:10.1002/pros

Gene set enrichment analysis (GSEA) (also called functional enrichment analysis or pathway enrichment analysis) is a method to identify classes of genes

renal, colon, and breast cancer. Cordycepin reduces viable A549 lung cancer cell populations by 50%. By acting at RUVBL2, cordycepin is the most potent

"A multigenic program mediating breast cancer metastasis to bone". Cancer Cell. 3 (6): 537–49. doi:10.1016/s1535-6108(03)00132-6. PMID 12842083. Minn

seen in BRCA1 deficiency), resulting in increased HRR that may enable cancer cell survival by partially ameliorating the excess of DNA damage. Under-expression

cellular adhesion and phagocytosis. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may

Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer. Cancer Cell, 31(6), 790-803.e8. https://doi.org/10.1016/j.ccell.2017.05.003 ‌ GRCh38:

tumor suppressor genes, IL-30 favors cancer cell proliferation, migration, and dissemination. That may boost cancer cell expression of cytokines and chemokines

Early studies identified that SWI/SNF subunits were frequently absent in cancer cell lines. SWI/SNF was first identified in 1998 as a tumor suppressor in

studies and in animal models, and the inhibitory effect of caffeic acid on cancer cell proliferation by an oxidative mechanism in the human HT-1080 fibrosarcoma

"Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way". Cancer Cell. 3 (3): 201–2. doi:10.1016/S1535-6108(03)00049-7. PMID 12676577. Sun

trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell". Cancer Res. 65 (1): 105–12. doi:10.1158/0008-5472.105.65.1. PMID 15665285

androgen receptor-positive prostate cancer cell line, but was absent from androgen receptor-negative prostate cancer cell lines as well as other cell lines

chromatin, and therefore results in weak signals for the cancer cell output. These weak signals may result in a false positive result for a cancer cell.

but also may affect signal transduction, leading to uncontrollable cancer cell growth. In epithelial cell cancers, disrupted cell-to-cell adhesion might

but also may affect signal transduction, leading to uncontrollable cancer cell growth. In epithelial cell cancers, disrupted cell-to-cell adhesion might

through the inhibitory activity of the BCR/ABL-regulated SET protein". Cancer Cell. 8 (5): 355–368. doi:10.1016/j.ccr.2005.10.015. PMID 16286244. Trotta

RNA-seq and ChIP-seq see little to no such effect at least in several cancer cell lines. GRCh38: Ensembl release 89: ENSG00000147421 – Ensembl, May 2017

mediated by oestrogen receptor alpha. However, in ER-positive breast cancer cell line MCF-7, estradiol caused a dose-dependent decrease in LKB1 transcript

phytoestrogen as it was shown to stimulate estrogen-dependent breast cancer cell growth in vivo. At a concentration of 1200 ppm, genistin caused significant

hereditary disease affecting the red blood cells. 6PGD is involved in cancer cell metabolism so 6PGD inhibitors have been sought. Parietin, a 6PGD inhibitor

cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". British Journal of Cancer. 92 (2): 342–9. doi:10.1038/sj.bjc

this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate

(February 2003). "Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis". Protein and

pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion". Cancer Biol Ther. 10 (8): 748–757. doi:10

supplementally, when NCAPH is depleted, studies show a decrease in colon cancer cell proliferation.  Studies show that high expression of NCAPH in colon cancer

and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration". doi:10.1101/2020.01.15.907931. S2CID 213030137. Retrieved

7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines" (PDF). Steroids. 77 (5): 542–51. doi:10.1016/j.steroids.2012.01

Lehtonen HJ, Visakorpi T (2006). "Overexpression of EIF3S3 promotes cancer cell growth". Prostate. 66 (11): 1144–50. doi:10.1002/pros.20452. PMID 16652384

cell surface protein in breast tumors that mediates lung metastasis". Cancer Cell. 5 (4): 365–74. doi:10.1016/S1535-6108(04)00079-0. PMID 15093543. Sutherland

formation in soft agar, and to decrease invasive potential of human prostate cancer cell line (PC-3 cells). It is now believed to be a chaperon molecule involved

Professor Sir John Gurdon. In 2001, he founded the Medical Research Council Cancer Cell Unit in 2001, and was Director of the Unit until 2010. Laskey is also

Vecchione A (2008). "MicroRNA signatures in human ovarian cancer". Cancer Cell. 13 (3): 272–286. doi:10.1016/j.ccr.2008.02.013. PMID 18328430. Yanaihara

"Tumor entrained neutrophils inhibit seeding in the premetastatic lung". Cancer Cell. 20 (3): 300–14. doi:10.1016/j.ccr.2011.08.012. PMC 3172582. PMID 21907922

system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. GRCh38: Ensembl release 89:

cells use to invade their surroundings. Several microRNAs that suppress cancer cell invasion have also been reported to act in part by targeting the Myo10

(30 July 2014), Diagram showing a monoclonal antibody attached to a cancer cell., archived from the original on 6 August 2022, retrieved 4 August 2022

sensitizes these cells to PAC-1-type compounds. Recent experiments using cancer cell lines with CRISPR deletion of CASP3 are also consistent with this result

Biology DCB oversees approximately 2000 grants per year in the areas of cancer cell biology; cancer immunology, hematology, and etiology; DNA and chromosome

deregulations at a transcriptional and posttranscriptional level. Trop-2 causes cancer cell growth, proliferation, invasion, migration, and survival of cancer cells

the tumor, and the expression of proteins and genes. As knowledge of cancer cell biology develops these classifications are updated. The purpose of classification

targeted antibodies (see ADC), e.g. antibodies against a certain type of cancer cell. The hydrazone-based bond is stable at neutral pH (in the blood), but

"Role of ribophorin II in the response to anticancer drugs in gastric cancer cell lines". Oncology Letters. 9 (4): 1861–1868. doi:10.3892/ol.2015.2900

canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer

antimicrobial, antidiabetic, PDE5 inhibitor, and cytotoxicity for several cancer cell lines. Peterson and Fristad (2000) investigated folklore beliefs stating

further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts

snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion". npj Breast Cancer. 3: 25. doi:10.1038/s41523-017-0032-8. PMC 5503938

antimetabolites have high cell cycle specificity and can target arrest of cancer cell DNA replication. Anthracyclines are anti-tumor antibiotics that interfere

cancers with pharmaceuticals and functional imaging agents, such as cancer cell specific positron emission tomography (PET) imaging using the αvβ6-integrin

intriguing biological possibilities, especially its cytotoxicity to some cancer cell lines. Before the cylindrocyclophanes, the cyclophanes had all been produced

acid (FTS, Salirasib) exhibits profound anti-oncogenic effects in many cancer cell lines. Inappropriate activation of the gene has been shown to play a

KC, Xu W, Suen JY, Fairlie DP (November 2020). "PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR"

role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines". Cancer Res. 69 (8): 3356–63. doi:10.1158/0008-5472.CAN-08-4112

"Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways". Scientific Reports.

recently (updated in the year of 2023), he has significantly contributed to cancer cell unjamming. Josef Alfons Käs studied at the Technische Universität München

Therapeutics' Pralatrexate Demonstrates Anticancer Activity in Multiple Cancer Cell Lines". [1], Memorial Sloan Kettering Cancer Center Press Release, "FDA

cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210

"Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation". Cancer Research. 66 (2): 729–35. doi:10

Perdrix Rosell is a Spanish scientist who completed her PhD[when?] in cancer cell signalling at the Francis Crick Institute in London. She co-founded a

is the target binding site, it may be on the surface of the targeted cancer cell for therapeutic purposes. Radioisotopes can occur naturally or be synthesized

RBPs—NSUN6, ZC3H13, BYSL, ELAC1, RBMS3, and ZGPAT—in colorectal and liver cancer cell lines. Several studies have found a causal, predictable connection between

mitochondrial membrane permeability. Ferroptosis, a process that promotes cancer cell death, can be activated with solasonine by increasing and catalyzing

on cell lines, specific to cancer cells (no measurable effect on non-cancer cell lines), experiments carried out with EPFL. antibacterials based on IFRA

leukemia cells by the small molecule tyrosine kinase inhibitor PKC412". Cancer Cell. 1 (5): 433–43. doi:10.1016/S1535-6108(02)00069-7. PMID 12124173.{{cite

line protective measure for UK chemotherapy centres” Published report: Cancer Cell Dec 2020-July 2021, Paediatric cancer patients Headline findings: “children

inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro". Breast Cancer Research. 11 (5): R77. doi:10.1186/bcr2419

expression can be detected in normal ovarian cells; however, several ovarian cancer cell lines do not express GPC3. On the other hand, GPC3 expression is undetectable

agents, including by the hyperactivation of ClpP to cause selective cancer cell lethality. Intracellular proteases have a role in bacterial virulence

dendritic cell via the heavy chains, an immunological reaction against the cancer cell is triggered. Removing cancer cells from the abdominal cavity reduces

"Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–1310. doi:10.1083/jcb.141

regulations are particularly important for tumor development and influence cancer cell growth, invasion, inflammation, and angiogenesis. CAFs may also exhibit

S2CID 4266100. Boulay A, Masson R, Chenard MP, et al. (2001). "High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3

distinct from endogenous retroviruses and are not detectable in breast cancer cell lines or biopsies". Virology. 318 (1): 393–404. doi:10.1016/j.virol.2003

expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

et al. (May 2007). "Rewired ERK-JNK signaling pathways in melanoma". Cancer Cell. 11 (5): 447–60. doi:10.1016/j.ccr.2007.03.009. PMC 1978100. PMID 17482134

Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87. Gomez-Raya L, Olsen HG, Lingaas F, Klungland

macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy". Cancer Cell. 25 (6): 846–859. doi:10.1016/j.ccr.2014.05.016. PMID 24898549. Ries

of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer. 5: 104. doi:10.1186/1471-2407-5-104. PMC 1208863

where miR-203 is epigenetically silenced by hypermethylation. In lung cancer cell lines, miR-203 has been shown to target DKK1, a secreted protein which

responses to genotoxic damage in neural progenitors and malignant glioma". Cancer Cell. 19 (3): 359–71. doi:10.1016/j.ccr.2011.01.035. PMC 3070398. PMID 21397859

between hereditary and sporadic type 2 papillary renal cell carcinoma". Cancer Cell. 20 (4): 511–523. doi:10.1016/j.ccr.2011.08.024. PMID 22014576. Yogev

the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion". Oncogene. 19 (10): 1318–28. doi:10.1038/sj.onc.1203422. PMID 10713673

potent, diffusable antioxidant that resists oxidative stress and enables cancer cell survival. Guanosine triphosphate (GTP) Tetrahydrobiopterin (THB, BH4)

Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor. One elucidated pathway shows

occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance. Evidence emerged

F.; Moussa, M.; Carroll, K. K. (1996). "Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus

J, Haendler B (2011). "The antiprogestin Lonaprisan inhibits breast cancer cell proliferation by inducing p21 expression". Mol. Cell. Endocrinol. 333

treatment of cancer. Ironomycin was shown to induce ferroptosis in breast cancer cell lines and its mechanism of action involves the targeting of lysosomal

upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi:10.1038/sj.onc.1208573. PMID 15782117

dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase". Cancer Cell. 7 (1): 77–85. doi:10.1016/j.ccr.2004.11.022. PMID 15652751. MacKenzie

Ser-15 residues necessary to p53 apoptotic activity. Studies on lung cancer cell lines (A549 cells) showed an increase in apoptosis in response to genotoxic

found that EMT can happen in breast cancer cell lines with hypermethylation of CDH1 promoter, but in breast cancer cell lines with a CDH1 mutational inactivation

Foxp3 in melanoma,[citation needed] glioma, breast, prostate and ovarian cancer cell lines induces profound growth inhibitory effects in vitro and in vivo

T47D human breast cancer cell line, which suggested that the extract may exert its anti-proliferative effect on human breast cancer cell line by suppressing

maze test and an object recognition task. CRABP1 is also involved in cancer cell apoptosis. trans-retinoic acid was considered a [null therapeutic target

enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate". Cancer Cell. 17 (3): 225–34. doi:10.1016/j.ccr.2010.01.020. PMC 2849316. PMID 20171147

antibacterial and anti-fungal activity, and have been found to inhibit cancer cell growth. Furthermore, navy beans are the richest source of ferulic acid

serves as the Director of Columbia University Irving Medical Center’s Cancer Cell Therapy Initiative in the Herbert Irving Comprehensive Cancer Center

BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines". Oncogene. 14 (18): 2195–2200. doi:10.1038/sj.onc.1201065. PMID 9174055

'Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines', Process Biochemistry. Vol. 41, no. 5, May 2006. Brian Baker,

of live human cells". Nature Methods. 3 (5): 385–390. doi:10.1038/nmeth876. ISSN 1548-7091. Cancer Cell Lines and Primary Cells Retrieved 2011-10-14.

efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell death & disease. 2022 Apr 19;13(4):374. Nobiletin[usurped], phytochemicals

various other lichen. It has exhibited moderate activity toward several cancer cell lines. Of greater interest is the structural skeleton and chemical space

extensively to understand the molecular biology of cell motility and cancer cell dormancy by in-depth exploration of the process of encystation. The recently

1002/art.20313. PMID 15248212. Hotary K, Li XY, Allen E, et al. (2006). "A cancer cell metalloprotease triad regulates the basement membrane transmigration

angiogenesis, supporting the formation of tumours and thus proliferation of cancer cell and metastasis. Cancer cells are usually also drug resistant, which is

Immunofluorescence micrograph of three cytotoxic T cells (outer three) surrounding a cancer cell. Lytic granules (red) are secreted at the contact site, killing the target

antifungal that inhibits Hedgehog pathway activity and cancer growth". Cancer Cell. 17 (4): 388–399. doi:10.1016/j.ccr.2010.02.027. PMC 4039177. PMID 20385363

and TNBC. GDF11 is also capable of inducing apoptosis in pancreatic cancer cell lines. However, In 130 patients with colorectal cancer (CRC), the expression

caBIG technology. In 2008, GlaxoSmithKline announced it would share cancer cell genomic data with caBIG. Some private companies claimed benefits from

significance in cancer research since cell motility is a key feature of cancer cell behaviour during metastasis (the spread of tumours around the human body)

chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel". Invest New Drugs. 23 (2): 121–2. doi:10

Pienta KJ (1993). "Effect of prostatic inhibin peptide (PIP) on prostate cancer cell growth in vitro and in vivo". Prostate. 22 (3): 225–33. doi:10.1002/pros

University. She is the founding director of the Stanford Center for Cancer Cell Therapy. Mackall grew up in East Palestine, Ohio in a working-class family;

et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(2

terms, by varying or different genes or alleles. In cancer research, cancer cell heterogeneity is thought to be one of the underlying reasons that make

JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line". Cell. Signal. 21 (6): 892–8. doi:10.1016/j.cellsig.2009.01.034

repress translation or trigger degradation of target RNAs.) In breast cancer cell lines, almost one third (55/167) of miRNA promoters were targets for

"Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines". Cancer Research. 54 (22): 5974–5980. PMID 7954430. Spittler,

consequently cancer cell apoptosis. Experiments show that INH1 potently inhibits the proliferation of multiple human breast cancer cell lines, cervical

alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Molecular Biology Reports. 36 (4): 691–6. doi:10.1007/s11033-008-9230-7

ATPase in cancer. Mutations in this gene were first recognized in human cancer cell lines derived from lung. In cancer, mutations in BRG1 show an unusually

bioactivity of euphol has shown concentration-dependent cytotoxic effects on cancer cell lines, with more than a five-fold difference in the IC50 values in some

treat Parkinson's disease. Dysregulation of O-GlcNAc is associated with cancer cell proliferation and tumor growth. O-GlcNAcylation of the glycolytic enzyme

were unfounded and based only on preliminary laboratory research on cancer cell inhibition, a finding that was never confirmed in other laboratory or

caused a controversy and eventual retraction. There were over 50 human cancer cell lines that were claimed to be linked to murine leukemia virus-related

progression of a tumor. In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed

"Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy". Nanomedicine. 8 (1): 17–28

potent, diffusable antioxidant that resists oxidative stress and enables cancer cell survival via promotion of angiogenesis. "Sapropterin (Kuvan) Use During

oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0

(August 2002). "An essential role for DNA methyltransferase DNMT3B in cancer cell survival". The Journal of Biological Chemistry. 277 (31): 28176–81. doi:10

body, as well as a clearer image of tumors by improving accuracy of cancer cell identification. They also allow for a more efficient and smaller, MRAM

signaling has proliferative effects in both normal breast and breast cancer cell lines, whereas ERβ has generally antiproliferative effects in such cell

anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402". Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal

promotes tumor formation and is upregulated in colon cancer and other cancer cell types. This transcript may regulate long range chromosomal interactions

tumor cells. Research has used mitochondrial mutations as biomarkers for cancer cell therapy. It is easier to target mutation within mitochondrial DNA versus

anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". J. Cell. Physiol. 212 (3): 655–65. doi:10.1002/jcp.21059

from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line". BMC Cancer. 6 (213): 213. doi:10.1186/1471-2407-6-213. PMC 1560389

in many prostate cancer cell lines and Dendreon/Genentech are pursuing an agonist approach to induce apoptosis and prostate cancer cell death. TRPM8 channels

specifically required for cisplatin-induced apoptosis of the ovarian cancer cell line, OV207. The mechanism by which Sulf1 is downregulated in ovarian

factor p53, responsible for encoding the tumour suppressor protein p53. Cancer cell lines with an inactive p53 pathway show a vulnerability to miR-31 overexpression

PMID 17355992. Lund AH (February 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58.

loss of Hic1 function accentuates the role of p53 in tumorigenesis". Cancer Cell. 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761. Britschgi

showed that a cancer mutation could confer an advantage, so that a future cancer cell would outcompete surrounding normal cells, and moreover that this advantage

effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines". Food and Chemical Toxicology. 37 (4): 271–85. doi:10.1016/S0278-6915(99)00019-8

deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer". Cell. 82 (2): 321–30. doi:10.1016/0092-8674(95)90319-4. PMID 7628020. S2CID 7954019

"Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation". British Journal

in many prostate cancer cell lines and Dendreon/Genentech are pursuing an agonist approach to induce apoptosis and prostate cancer cell death. TRPM8 channels

(May 2003). "Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity". Oncogene. 22 (22): 3424–3430

Chen W, Qin H, Diao W, Li B, Cao W, et al. (May 2019). "TOX3 inhibits cancer cell migration and invasion via transcriptional regulation of SNAI1 and SNAI2

a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor

Professor of Biochemistry. Machesky's research group specialises in cancer cell migration, invasion, metastasis and the energetics of cell biology. She

that are usually limited in translation and only proteins needed for cancer cell growth will be synthesized. This includes proteins involved in growth

kinase (ERK). Research shows that it had a pro-apoptotic activity on cancer cell lines U937, Eol-1 and Jurkat T cells. Its cytotoxic activity was inhibited

into for its anti-cancer properties, including slowing the growth of cancer cell lines. "Hypericum adenotrichum Spach". ipni.org. International Plant

phosphate donor. Many of these proteins contribute to the regulation of cancer cell proliferation. Specifically, PKM2 can be a component in mitogen-activated

Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines and its over-expression and distinct membrane localisation is also

cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines". Scandinavian Journal of Gastroenterology. 34 (12): 1224–9. doi:10

"Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110)". Biochem. Biophys

Bioelectronics could be used to develop new label-free methods for monitoring cancer cell invasion and drug resistance. For example, the electrical resistance

broad cellular tropism and the ability to infect a wide range of human cancer cell lines.  Neither virus has been isolated, hindering research. EKV-1 and

considered as an incomplete scenario, despite the idea of the genome of the cancer cell undergoing a reduction of its 5-methylcytosine content when compared

methicillin-resistant Staphylococcus aureus (MRSA), in addition to four different human cancer cell lines in vitro. As antivirals, however, DPKs appear to have a poor outlook

appear to contribute to the apoptosis of cancer cells and a decrease in cancer cell proliferation. DATS can be metabolized by glutathione in red blood cells

Sciences in Split (Croatia). He is an expert in the field of proteomics, cancer cell signalling and COVID-19 serological testing.[citation needed] He received

host and pathogenic bacteria. Quorum sensing may also be useful for cancer cell communications. In addition to its function in biological systems, quorum

leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro". Phytotherapy Research. 22 (12): 1684–1687. doi:10.1002/ptr

PMC 139241. PMID 12477932. Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int

"Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". Prostate. 49 (1): 72–8. doi:10.1002/pros.1119. PMID 11550212

cytokines, ECM and angiogenic responses in PaSCs, which in turn induce cancer cell proliferation. Matri-cellular proteins may therefore directly contribute

treatment with tamoxifen and estrogen receptor β agonists on human breast cancer cell lines". Arch. Gynecol. Obstet. 289 (1): 163–71. doi:10.1007/s00404-013-2977-7

2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.

proliferative genes, c-myc and cyclin D1, or stimulate MCF-7 breast cancer cell proliferation or tumor formation, demonstrating that it may be a viable

progression in the absence of pocket protein activity". December 2005, Cancer Cell, Vol. 8, pp. 455-466 Gemberling et al. "Nrg1 is an injury-induced cardiomyocyte

template is "Molecule X from lichen species Y inhibits the growth of cancer cell Z". He created a database of molecules, lichens, and cancer cells to

Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration". European Journal of Organic Chemistry. 2008 (11): 1953–1958

subunit of the NuRD complex and targets the metastasis programs in breast cancer". Cell. 138 (4): 660–72. doi:10.1016/j.cell.2009.05.050. PMID 19703393. Ciccone

(2004). "Regulation of HDM2 activity by the ribosomal protein L11". Cancer Cell. 3 (6): 577–587. doi:10.1016/S1535-6108(03)00134-X. PMID 12842086. Odintsova

and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell, doi:10.1016/j.ccell.2022.02.003(2022). Zhou, J. et al. 2021. The ubiquitin

Kyprianou N, Benning CM (August 2000). "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via

as a differentially expressed gene in a highly metastatic rat breast cancer cell line. The role in MTA1 in chromatin remodeling was deduced due to the

vivo especially in certain types of cancer cell lines. The association between MCMs and proliferation in cancer cell lines is mostly attributed to its ability

and TNFRSF14. Conversely, KMT2D deficiency in several breast and colon cancer cell lines leads to reduced proliferation. Increased KMT2D was shown to facilitate

Kepros J, Yang CY, Zhang M, et al. (August 2008). "Elesclomol induces cancer cell apoptosis through oxidative stress". Molecular Cancer Therapeutics. 7

a terminal metabolite as isotope labelling experiments of colorectal cancer cell lines show that its conversion back to alpha-ketoglutarate is too low

of cultured cancer cells. These malignant behaviors include cultured cancer cell motility and proliferation which are regarded as being related to the

novel and previously described cell membrane markers in human breast cancer cell lines and tumors". Clin. Cancer Res. 11 (12): 4357–64. doi:10.1158/1078-0432

to be involved in cancer progression. They have been shown to mediate cancer cell proliferation and metastasis. α7 receptors are also involved in angiogenic

SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer. 29A (11): 1578–84. doi:10

somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology. 7 (3): 91–8. doi:10.1016/S1078-1439(01)00173-9

The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated