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Longer titles found: List of breast cancer cell lines (view), Cancer Cell (journal) (view), Cancer Cell International (view), RNAi-Based Identification System and interference of Specific Cancer Cells (view)

searching for Cancer cell 477 found (2399 total)

alternate case: cancer cell

MRC Cancer Unit (293 words) [view diff] case mismatch in snippet view article find links to article

Biomedical Campus. The MRC Cancer Unit was established in 2001 (as the MRC Cancer Cell Unit) by Professor Ron Laskey CBE, who was also appointed as the unit's
ERX-11 (733 words) [view diff] exact match in snippet view article find links to article
the growth of the ZR-75 and MCF-7 breast cancer cell lines. It was inactive in ER-negative breast cancer cell lines. In contrast to conventional antiestrogens
Cixutumumab (617 words) [view diff] exact match in snippet view article find links to article
Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor
Apoptosis (10,857 words) [view diff] exact match in snippet view article find links to article
gene, resulting in the increase of p53 protein level and enhancement of cancer cell-apoptosis. p53 prevents the cell from replicating by stopping the cell
MCF-7 (1,169 words) [view diff] exact match in snippet view article find links to article
MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute
MELK (977 words) [view diff] exact match in snippet view article find links to article
essential for cancer cell proliferation. However, recent research using CRISPR has demonstrated that MELK is fully dispensable for cancer cell growth, casting
G12/G13 alpha subunits (457 words) [view diff] exact match in snippet view article find links to article
cytoskeletal remodeling in cells during movement and migration, including cancer cell metastasis. G13 is also essential for receptor tyrosine kinase-induced
Mir-612 microRNA precursor family (216 words) [view diff] exact match in snippet view article find links to article
pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. The microRNA miR-2185
NCI-60 (895 words) [view diff] exact match in snippet view article find links to article
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds
Sofituzumab vedotin (164 words) [view diff] exact match in snippet view article find links to article
cytotoxic agent MMAE, which is released after internalization by the cancer cell. In addition to its direct cytotoxic effect, sofituzumab vedotin may
NNC 45-0095 (280 words) [view diff] exact match in snippet view article find links to article
(EmaxTooltip maximal efficacy (relative to moxestrol, in Ishikawa endometrial cancer cell line) = 105%). The compound is a pyrrolo indolizine derivative. Its development
Miproxifene (300 words) [view diff] exact match in snippet view article find links to article
to be 3- to 10-fold more potent than tamoxifen in inhibiting breast cancer cell growth in in vitro models. Miproxifene is the active metabolite of miproxifene
Bavituximab (680 words) [view diff] exact match in snippet view article find links to article
membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies, and when cells are infected with hepatitis C. The process of
Miproxifene phosphate (329 words) [view diff] exact match in snippet view article find links to article
found to be 3- to 10-fold as potent as tamoxifen in inhibiting breast cancer cell growth in in vitro models. It is a derivative of afimoxifene (4-hydroxytamoxifen)
Dauricine (376 words) [view diff] exact match in snippet view article find links to article
so. Dauricine has been studied in vitro for its potential to inhibit cancer cell growth and to block cardiac transmembrane Na+, K+, and Ca2+ ion currents
MAPK4 (602 words) [view diff] exact match in snippet view article find links to article
cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth. ENSG00000282110
MMP2 (2,812 words) [view diff] exact match in snippet view article find links to article
is an essential step for the metastatic progression of most cancers. Cancer cell invasion, ECM degradation, and metastasis are highly linked with the
Mir-145 (1,481 words) [view diff] exact match in snippet view article find links to article
and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80. doi:10.1038/onc
Lipocalin (2,092 words) [view diff] exact match in snippet view article find links to article
transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. Lipocalin proteins are important key players of nutritional
Robert Weinberg (biologist) (1,345 words) [view diff] exact match in snippet view article
century, advances in genetics led to the discovery of over one hundred cancer cell types. Cancer cells were noted for their bewildering diversity. It was
Autocrine signaling (2,105 words) [view diff] exact match in snippet view article find links to article
mechanism for constitutive Wnt pathway activation in human cancer cells". Cancer Cell. 6 (5): 497–506. doi:10.1016/j.ccr.2004.09.032. PMID 15542433. Schlange
Epithelial–mesenchymal transition (6,840 words) [view diff] exact match in snippet view article find links to article
and TGF-β receptor 2 in a pancreatic cancer cell line. Overexpression of the miR-655 mimic in the Panc1 cancer cell line upregulated the expression of E-cadherin
Trey Ideker (566 words) [view diff] case mismatch in snippet view article find links to article
for Network Biology, the San Diego Center for Systems Biology, and the Cancer Cell Map Initiative. He uses genome-scale measurements to construct network
Antineoplastic resistance (3,844 words) [view diff] exact match in snippet view article find links to article
acquired resistance after drug exposure, which is rooted in the concept of cancer cell heterogeneity. Characteristics of resistant cells include altered membrane
PTPRH (570 words) [view diff] exact match in snippet view article find links to article
level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. GRCh38: Ensembl release
2-Methoxyestradiol (916 words) [view diff] exact match in snippet view article find links to article
inhibitor. It also acts as a vasodilator and induces apoptosis in some cancer cell lines. 2-Methoxyestradiol is derived from estradiol, although it interacts
RAC1 (3,077 words) [view diff] exact match in snippet view article find links to article
tissues, deregulation of cell motility is one of the hallmark events in cancer cell invasion and metastasis. Overexpression of a constitutively active Rac1
DU145 (733 words) [view diff] exact match in snippet view article find links to article
(DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research
Pyrvinium (346 words) [view diff] exact match in snippet view article find links to article
pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation. One synthetic method is based on Skraup
Carnosol (174 words) [view diff] exact match in snippet view article find links to article
pachyphylla). It has been studied in-vitro for anti-cancer effects in various cancer cell types. Carnosic acid List of phytochemicals in food Ai-Hsiang Lo; Yu-Chih
Tisagenlecleucel (1,806 words) [view diff] exact match in snippet view article find links to article
both a T-cell receptor and an antibody specific to a protein on the cancer cell, and transferred back to the person. The T cells are engineered to target
Zeranol (457 words) [view diff] exact match in snippet view article find links to article
under the brand name Ralone in Spain. Although zeranol may increase cancer cell proliferation in already existing breast cancer, dietary exposure from
Reactive oxygen species (8,525 words) [view diff] exact match in snippet view article find links to article
inhibit cancer cell proliferation. Although ROS can promote tumor cell proliferation, a great increase in ROS has been associated with reduced cancer cell proliferation
Luis Jose De Souza (803 words) [view diff] case mismatch in snippet view article find links to article
Mumbai and Goa. He has also contributed to the establishment of Indian Cancer Cell, an educational program co-sponsored by Tata Memorial Centre, Union for
Annual Review of Cancer Biology (514 words) [view diff] exact match in snippet view article find links to article
Attardi and Scott A. Armstrong. It is content is broadly focused on cancer cell biology, tumorigenesis and cancer progression, and translational cancer
Epothilone (2,166 words) [view diff] exact match in snippet view article find links to article
epothilones A to F have been identified and characterized. Early studies in cancer cell lines and human cancer patients indicate superior efficacy to the taxanes
Type IV collagen (2,425 words) [view diff] exact match in snippet view article find links to article
on the cancer cell surface that colocalize with the integrin receptors. The interaction between type IV collagen produced by the cancer cell, and integrins
Hyaluronan synthase (2,531 words) [view diff] exact match in snippet view article find links to article
effects and therapeutic potentials. HAS2 is overexpressed in breast cancer cell lines and is associated with lymph node metastasis, while HAS1 and HAS3
Mucin 4 (2,092 words) [view diff] exact match in snippet view article find links to article
been found for MUC4 using commercial mRNAs or total RNAs extracted from cancer cell lines. Some predicted forms are soluble, while others are membrane bound
Mucin 4 (2,092 words) [view diff] exact match in snippet view article find links to article
been found for MUC4 using commercial mRNAs or total RNAs extracted from cancer cell lines. Some predicted forms are soluble, while others are membrane bound
MTA3 (1,763 words) [view diff] no match in snippet view article find links to article
Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell. 113 (2): 207–19. doi:10.1016/S0092-8674(03)00234-4. PMID 12705869.
Peter MacCallum Cancer Centre (828 words) [view diff] case mismatch in snippet view article find links to article
the centre include the Australian Cancer Research Foundation (ACRF) Cancer Cell Biology Program and the ACRF Victorian Centre for Functional Genomics
Molecular oncology (1,208 words) [view diff] exact match in snippet view article find links to article
antigen, the physical structure of the T cell changes to destroy the cancer cell. This is a method of cancer treatment that works on the cellular and
MDA-MB-453 (1,323 words) [view diff] exact match in snippet view article find links to article
MDA-MB-453 is a human breast cancer cell line. The MDA-MB-453 cell cancer line was derived in 1976 from the pericardial effusion of a 48-year-old female
Taxifolin (1,752 words) [view diff] exact match in snippet view article find links to article
ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. However, in this same study, taxifolin
Invadopodia (1,535 words) [view diff] exact match in snippet view article find links to article
their ability to invade through the extracellular matrix, especially in cancer cell extravasation. Invadopodia are generally visualized by the holes they
MMP27 (1,345 words) [view diff] exact match in snippet view article find links to article
MMP-27 was also identified, at the protein level, in MDA-MB-231 breast cancer cell line and in primary human breast cancer. Recently, MMP-27 has been demonstrated
T-47D (285 words) [view diff] exact match in snippet view article find links to article
T-47D is a human breast cancer cell line commonly used in biomedical research involving the hormonal expression of cancer cells. The cells were derived
WNT6 (586 words) [view diff] exact match in snippet view article find links to article
overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression
Intravasation (979 words) [view diff] exact match in snippet view article find links to article
metastatic sites. Cancer cell chemotaxis also relies on this migratory behavior to arrive at a secondary destination designated for cancer cell colonization
Oncogene (journal) (245 words) [view diff] exact match in snippet view article
peer-reviewed scientific journal published under the Springer Nature addressing cancer cell genetics and the structure and function of oncogenes. The journal has
Hep G2 (577 words) [view diff] exact match in snippet view article find links to article
Hep G2 (or HepG2) is a human liver cancer cell line. Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old
Metabolic pathway (3,020 words) [view diff] exact match in snippet view article find links to article
there are various pathways that can be targeted by compounds to prevent cancer cell proliferation. One such pathway is oxidative phosphorylation (OXPHOS)
Dose fractionation (776 words) [view diff] exact match in snippet view article find links to article
should be used in using results for a cancer cell line to make predictions for healthy cells if the cancer cell line is known to be resistant to cytotoxic
GPR31 (1,651 words) [view diff] exact match in snippet view article find links to article
supported by studies that cloned the receptor from the PC-3 prostate cancer cell line. The cloned receptor, when expressed in other cell types, bound
Nilotinib (1,908 words) [view diff] exact match in snippet view article find links to article
kinase inhibitor and works by interfering with signalling within the cancer cell. Nilotinib was approved for medical use in the United States in 2007
Pyrimidine dimer (1,947 words) [view diff] exact match in snippet view article find links to article
precipitate mutations within an organism's genome, potentially culminating in cancer cell formation. Unrectified lesions may also interfere with polymerase function
CD3 (immunology) (757 words) [view diff] exact match in snippet view article
altering the co-stimulatory signal to help get the T-cell to recognize the cancer cell and become fully activated. Cancers that possess the B7-H3 immunoregulatory
Aurora kinase C (1,969 words) [view diff] exact match in snippet view article find links to article
centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative
ID4 (3,045 words) [view diff] exact match in snippet view article find links to article
also seen to be overexpressed in most ovarian, endometrial and breast cancer cell lines. The mechanism behind this is believed to be that ID4 regulates
HCT116 cells (406 words) [view diff] exact match in snippet view article find links to article
HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings. HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene
Growth curve (biology) (482 words) [view diff] no match in snippet view article
A growth curve is an empirical model of the evolution of a quantity over time. Growth curves are widely used in biology for quantities such as population
MiR-150 (658 words) [view diff] exact match in snippet view article find links to article
miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than
PC3 (1,813 words) [view diff] exact match in snippet view article find links to article
PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. PC3 cells are useful in investigating biochemical
K562 cells (1,386 words) [view diff] exact match in snippet view article find links to article
which express MHC class-I A2 and A3. K562 cells are part of the NCI-60 cancer cell line panel used by the National Cancer Institute. Many factors and components
Cancer immunology (3,766 words) [view diff] exact match in snippet view article find links to article
cell-based cancer vaccine) Obeid et al. investigated how inducing immunogenic cancer cell death ought to become a priority of cancer chemotherapy. He reasoned
Autologous immune enhancement therapy (2,109 words) [view diff] exact match in snippet view article find links to article
subjected to etc., Aberrant cell division takes place that ends up in a cancer cell and such aberrance may be due to faulty stem cell, abnormal genetic components
Immunotherapy (6,093 words) [view diff] no match in snippet view article find links to article
under preliminary research for its potential to treat various forms of cancer. Cell-based immunotherapies are effective for some cancers. Immune effector
ARID1A (1,807 words) [view diff] case mismatch in snippet view article find links to article
with ARID1A loss driving pre-memory B cell fate and lymphomagenesis". Cancer Cell. 42 (4): 583–604.e11. doi:10.1016/j.ccell.2024.02.010. PMC 11407687.
Mir-26 microRNA precursor family (3,054 words) [view diff] exact match in snippet view article find links to article
miR-26a delivery using adeno-associated virus (AAV) is able to inhibit cancer cell formation while also inducing tumour-specific apoptosis and providing
Modelling biological systems (2,156 words) [view diff] exact match in snippet view article find links to article
response to environmental and internal stimuli, such as a model of a cancer cell in order to find weaknesses in its signalling pathways, or modelling
Cecropin (1,552 words) [view diff] exact match in snippet view article find links to article
concentrations on the order of 10−6 M. Two multidrug-resistant breast and ovarian cancer cell lines also showed sensitivity to the peptides. Further, peptide anticancer
Sodium-coupled monocarboxylate transporter 1 (6,958 words) [view diff] exact match in snippet view article find links to article
also lower in three human cervical cancer cell lines (i.e., HeLa, abd, and CaSki cells) and a human uterus cancer cell line (i.e., SiHa cells) than normal
Eternal youth (1,092 words) [view diff] exact match in snippet view article find links to article
telomeres by adding bases to the ends and thus renewing the telomere. A cancer cell has in essence turned on the telomerase gene, and this allows them to
Isogenic human disease models (2,046 words) [view diff] exact match in snippet view article find links to article
from a normal to cancer genotype; or vice versa; in characterized human cancer cell lines such as HCT116 or Nalm6. There are several gene targeting technologies
Stanford Cancer Institute (469 words) [view diff] case mismatch in snippet view article find links to article
a donation by Jeffrey Rothschild established the Stanford Center for Cancer Cell Therapy, which supports research into the development of immunological
RUNX3 (1,848 words) [view diff] case mismatch in snippet view article find links to article
is a crucial early event in the development of lung adenocarcinoma". Cancer Cell. 24 (5): 603–616. doi:10.1016/j.ccr.2013.10.003. PMID 24229708. Lee JW
Dichlorophenolindophenol (386 words) [view diff] exact match in snippet view article find links to article
human cancer cells in an animal model of human melanoma; DCPIP-induced cancer cell death occurs by depletion of intracellular glutathione and upregulation
BT-20 (125 words) [view diff] exact match in snippet view article find links to article
BT-20 is a breast cancer cell line derived from a 74-year-old human female in 1958 by E.Y. Lasfargues and L. Ozzello. The cells technically came from
PFKFB4 (689 words) [view diff] exact match in snippet view article find links to article
6-biphosphatase 4 as an important regulator of prostate cancer cell survival". Cancer Discovery. 2 (4): 328–43. doi:10.1158/2159-8290.CD-11-0234
CYP4F12 (1,376 words) [view diff] exact match in snippet view article find links to article
proliferation; and inhibit the growth and metastasis of human breast and prostate cancer cell lines. It is suggested that the EDP and EEQ metabolites function in humans
Antibody–drug conjugate (3,943 words) [view diff] exact match in snippet view article find links to article
antibody–drug conjugate consists of three components: Antibody - targets the cancer cell surface and may also elicit a therapeutic response. Payload - elicits
WNT9A (648 words) [view diff] exact match in snippet view article find links to article
gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity
EEF1G (1,220 words) [view diff] exact match in snippet view article find links to article
Baffa R, Croce CM (August 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18):
Marc Lacroix (biochemist) (2,387 words) [view diff] exact match in snippet view article
Body JJ (1998). "Establishment and characterization of three new breast-cancer cell lines". International Journal of Cancer. 76 (5): 677–683. doi:10
Cyclin-dependent kinase 2 (4,161 words) [view diff] case mismatch in snippet view article find links to article
linked to its melanocyte-specific transcriptional regulation by MITF". Cancer Cell. 6 (6): 565–76. doi:10.1016/j.ccr.2004.10.014. PMID 15607961. Hoek KS
Mir-127 (1,084 words) [view diff] exact match in snippet view article find links to article
proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells". Cancer Cell. 9 (6): 435–43. doi:10.1016/j.ccr.2006.04.020. PMID 16766263. Robertus
Cucurbitacin E (1,179 words) [view diff] exact match in snippet view article find links to article
shows cytotoxicity to: The colon cancer cell line HCT-116 The lung cancer cell line NCI-H460 The breast cancer cell lines MCF-7 and ZR-75-1 The central
Fluorescence microscope (2,725 words) [view diff] exact match in snippet view article find links to article
Epifluorescent imaging of the three components in a dividing human cancer cell. DNA is stained blue, a protein called INCENP is green, and the microtubules
Debromoaplysiatoxin (2,188 words) [view diff] exact match in snippet view article find links to article
tumor promoter which has an anti-proliferative activity against various cancer cell lines in mice. The first reported case of seaweed dermatitis was from
PANC-1 (244 words) [view diff] exact match in snippet view article find links to article
PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of ductal cell origin. PANC-1 was derived from the tissue of a 56-year-old
Frizzled-7 (795 words) [view diff] exact match in snippet view article find links to article
et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation
Valspodar (103 words) [view diff] exact match in snippet view article find links to article
studies in animal models have found it to be effective at preventing cancer cell resistance to chemotherapeutics, but these findings did not translate
Gastrointestinal cancer (3,243 words) [view diff] exact match in snippet view article find links to article
treatment depends on the location of the tumor, as well as the type of cancer cell and whether it has invaded other tissues or spread elsewhere. These factors
NOSH-aspirin (170 words) [view diff] exact match in snippet view article find links to article
have found that four NOSH variants, evaluated in eleven different human cancer cell lines, were effective in inhibiting the growth of these cell lines. NOSH-1
Oleocanthal (1,218 words) [view diff] exact match in snippet view article find links to article
apoptosis. This is a result of lysosome membrane permeabilization promoting cancer cell death. Lysosomal membrane permeabilization is not activated by oleocanthal
Selinexor (2,726 words) [view diff] no match in snippet view article find links to article
exportin 1 and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests
MIA PaCa-2 (240 words) [view diff] exact match in snippet view article find links to article
MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development. In 1977, MIA PaCa-2 cells were
Mucin-16 (1,916 words) [view diff] exact match in snippet view article find links to article
and the human Fc portion has the ability to disrupt the heterotypic cancer cell adhesion mediated by the MUC16-mesothelin interaction. Mesothelin has
12-Hydroxyeicosatetraenoic acid (6,990 words) [view diff] exact match in snippet view article find links to article
production in cultured prostate cancer cell lines, have implicated 12-HETE (stereoisomer sometimes undefined) in cancer cell lines from various other human
LAPC4 (336 words) [view diff] exact match in snippet view article find links to article
culture dishes, where it can be propagated as an immortalized prostate cancer cell line. LAPC4 are a lowly adherent, epithelial cell line with high Androgen
Craig B. Thompson (2,348 words) [view diff] exact match in snippet view article find links to article
transformation. This work has contributed to the resurgent interest in cancer cell metabolism and may form the basis for translational therapies to exploit
BCAS1 (685 words) [view diff] exact match in snippet view article find links to article
region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However
FOXO6 (461 words) [view diff] exact match in snippet view article find links to article
Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013). "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters. 587 (14): 2105–11
Hippo signaling pathway (3,241 words) [view diff] exact match in snippet view article find links to article
mutated in familial and sporadic schwannomas. Additionally, several human cancer cell lines invoke mutations of the SAV1 and MOBK1B proteins. However, recent
Somatostatin receptor 1 (1,215 words) [view diff] exact match in snippet view article find links to article
expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sciences. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6
FUT5 (480 words) [view diff] exact match in snippet view article find links to article
3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells". International
VCaP (311 words) [view diff] exact match in snippet view article find links to article
culture dishes, where it can be propagated as an immortalized prostate cancer cell line. VCaP are an adherent, epithelial cell line with high Androgen receptor
AGR2 (3,024 words) [view diff] exact match in snippet view article find links to article
Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response
Tissue transglutaminase (3,866 words) [view diff] exact match in snippet view article find links to article
inflammation and tumor biology. tTG expression is elevated in multiple cancer cell types and is implicated in drug resistance and metastasis due to its
HT-29 (1,768 words) [view diff] exact match in snippet view article find links to article
HT-29 is a human colon cancer cell line used extensively in biological and cancer research. The HT-29 cell line was established in 1964 from the tumor
Bromodeoxyuridine (1,088 words) [view diff] exact match in snippet view article find links to article
labeling concentrations, it is widely preferred for in vivo studies of cancer cell proliferation. However, at radiosensitizing concentrations, BrdU becomes
S180 (147 words) [view diff] exact match in snippet view article find links to article
S180 is a murine Sarcoma cancer cell line. It has been commonly used in cancer research due to its rapid growth and proliferation in mice. The cell line
Karin Rodland (679 words) [view diff] exact match in snippet view article find links to article
Karin Dorinda Norlin Rodland (born 1949) is an American cancer cell biologist. She is a professor emeritus at Oregon Health and Science University. Rodland
Mir-661 microRNA precursor family (249 words) [view diff] exact match in snippet view article find links to article
SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers". Oncogene. 29
Patient derived xenograft (3,639 words) [view diff] exact match in snippet view article find links to article
engraftment success. Unlike creating xenograft mouse models using existing cancer cell lines, there are no intermediate in vitro processing steps before implanting
Xenotropic murine leukemia virus–related virus (2,683 words) [view diff] exact match in snippet view article find links to article
recombination between two mouse retroviruses during propagation of a prostate-cancer cell line in the mid-1990s. These findings raised serious questions concerning
Stuart Kauffman (3,391 words) [view diff] exact match in snippet view article find links to article
and that some of the developmentally inaccessible cell types might be cancer cell types. This suggested the possibility of "cancer differentiation therapy"
Karin Rodland (679 words) [view diff] exact match in snippet view article find links to article
Karin Dorinda Norlin Rodland (born 1949) is an American cancer cell biologist. She is a professor emeritus at Oregon Health and Science University. Rodland
Ergtoxin (1,169 words) [view diff] exact match in snippet view article find links to article
cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line". Cancer Cell Int. 11 (6): 6. doi:10.1186/1475-2867-11-6. PMC 3063814. PMID 21392380
RAD18 (1,207 words) [view diff] exact match in snippet view article find links to article
humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created. The protein encoded by this gene
Cytostasis (1,232 words) [view diff] exact match in snippet view article find links to article
nitric oxide (NO) is able to have a cytostatic effect on the human breast cancer cell line MDA-MB-231. Not only does nitric oxide stop cell growth, the study
Hair keratin (1,833 words) [view diff] exact match in snippet view article find links to article
structures, KRT81 expression has been observed in the SKBR3 human breast cancer cell line and metastatic lymph nodes of breast carcinomas, but not in normal
MLST8 (810 words) [view diff] exact match in snippet view article find links to article
hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited
CD16 (1,844 words) [view diff] exact match in snippet view article find links to article
presence of specific antibodies, and can kill primary leukemic cells, cancer cell lines, and cells infected with hepatitis B virus. In addition, CD16 is
Mir-205 (2,700 words) [view diff] exact match in snippet view article find links to article
probability of survival. This down regulation was also observed in breast cancer cell lines, including MCF-7 and MDA-MB-231 compared to the non-malignant cell
4T1 (780 words) [view diff] exact match in snippet view article find links to article
4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine
E-SCREEN (2,116 words) [view diff] exact match in snippet view article find links to article
bioassay measures estrogen-induced increase of the number of human breast cancer cell, which is biologically equivalent to the increase of mitotic activity
HOXC6 (1,241 words) [view diff] case mismatch in snippet view article find links to article
or proliferation when it was downregulated. According to a study in Cancer Cell International, suppression of the HOXC6 gene plays a role in blocking
Oct-4 (4,168 words) [view diff] exact match in snippet view article find links to article
pluripotency in embryonic cells but also has the ability to regulate cancer cell proliferation and can be found in various cancers such as pancreatic
Protein AATF (1,226 words) [view diff] case mismatch in snippet view article find links to article
affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794. Di
N-alpha-acetyltransferase 10 (4,937 words) [view diff] exact match in snippet view article find links to article
"N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity". Cancer Cell. 19 (2): 218–231. doi:10.1016/j
Homeobox protein CDX-1 (1,147 words) [view diff] exact match in snippet view article find links to article
"DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". The Journal of Biological Chemistry. 277 (39): 35795–35800. doi:10
ALOX12 (3,928 words) [view diff] exact match in snippet view article find links to article
17-hydroxy-HDHA, have been shown to inhibit the growth of cultured human prostate cancer cell by causing them to enter apoptosis. Studies on rodents lacking or made
Metastatic breast cancer (5,262 words) [view diff] exact match in snippet view article find links to article
nervous system. The main steps involved in the metastatic cascade of a cancer cell are: Cell division and growth within the primary tumor Invasion of the
Mir-143 (1,573 words) [view diff] exact match in snippet view article find links to article
has shown to be effective in blocking cell cycle progression of lung cancer cell lines. Moreover, this combination treatment reduces angiogenesis. This
CDKN1B (5,152 words) [view diff] exact match in snippet view article find links to article
These act to accelerate the proteolysis of the p27 protein and allow the cancer cell to undergo rapid division and uncontrolled proliferation. When p27 is
Regorafenib (909 words) [view diff] exact match in snippet view article find links to article
increase EDP levels in and inhibit the growth of several human renal cancer cell lines in vitro and 2) dietary DHA likewise acted synergistically with
ANGPTL4 (3,023 words) [view diff] exact match in snippet view article find links to article
implicated in the metastatic process by modulating vascular permeability, cancer cell motility and invasiveness. The former name, FIAF, stands for Fasting-Induced
Cancer genome sequencing (3,085 words) [view diff] exact match in snippet view article find links to article
the characterization and identification of the DNA or RNA sequences of cancer cell(s). Unlike whole genome (WG) sequencing which is typically from blood
Antiestrogen withdrawal response (293 words) [view diff] exact match in snippet view article find links to article
therapy in the breast to inhibit breast cancer growth and induce breast cancer cell death. The antiestrogen withdrawal syndrome is analogous to but less
Mir-624 microRNA precursor family (188 words) [view diff] exact match in snippet view article find links to article
pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. miR-624 has been found
Relda Marie Cailleau (1,654 words) [view diff] exact match in snippet view article find links to article
scientist primarily known for her establishment of a series of breast cancer cell lines that have been crucial to the discovery of anticancer drugs and
Lycorine (1,205 words) [view diff] exact match in snippet view article find links to article
properties. It has displayed various inhibitory properties towards multiple cancer cell lines that include, lymphoma, carcinoma, multiple myeloma, melanoma,
Mir-340 microRNA precursor family (386 words) [view diff] exact match in snippet view article find links to article
Zhang GH, Xu XC, Zhang N (July 2011). "miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met". Cancer
BxPC-3 (322 words) [view diff] exact match in snippet view article find links to article
BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof. BxPC-3 cells were derived
Ichthyotoxin (466 words) [view diff] exact match in snippet view article find links to article
euglonophycin was demonstrated in leukemia, neuroblastoma, and colorectal cancer cell lines. Specifically, in colorectal cancer cells, euglenophycin exposure
Measles virus encoding the human thyroidal sodium iodide symporter (639 words) [view diff] exact match in snippet view article find links to article
glycoprotein is a normal part of human tissue but may be overexpressed on some cancer cell types. MV-NIS is the first targeted engineered virus therapy to have
Phloretin (647 words) [view diff] exact match in snippet view article find links to article
and tested for its anticancer activity. Pht-GNPs showed significant cancer cell toxicities compared to free phloretin. Phlorizin is the 2'-glucoside
Rhabdastrella globostellata (267 words) [view diff] exact match in snippet view article find links to article
triterpene molecules with notable cytotoxic activity towards certain cancer cell lines. Swee Cheng Lim; Nicole de Voogd; Koh Siang Tan (2008). A guide
MRN complex (3,083 words) [view diff] exact match in snippet view article find links to article
upregulation of MRN complex sub-units has been documented in certain cancer cell lines when compared to non-malignant somatic cells, suggesting some cancer
4-Hydroxyestrone (1,093 words) [view diff] exact match in snippet view article find links to article
from stress and damage. In 2024, a study demonstrated 4-OHE1's role in cancer cell survival and its potential therapeutics for breast cancer treatment.
Binucleated cells (471 words) [view diff] exact match in snippet view article find links to article
carcinoma, cell line UPCI-SCC-103. A: The cancer cell treated with antibodies against tubulin. B: The same cancer cell stained with DAPI, highlighting the nuclei
TRIM68 (501 words) [view diff] exact match in snippet view article find links to article
protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted
ARGLU1 (274 words) [view diff] exact match in snippet view article find links to article
protein required for estrogen-dependent gene transcription and breast cancer cell growth. The ARGLU1 gene expresses at least three distinct RNA splice
ErbB (2,736 words) [view diff] case mismatch in snippet view article find links to article
ErbB signaling from the structure of the ErbB2-pertuzumab complex". Cancer Cell. 5 (4): 317–328. doi:10.1016/S1535-6108(04)00083-2. PMID 15093539. Bouyain
ZR-75-1 (124 words) [view diff] exact match in snippet view article find links to article
ZR-75-1 is a human breast cancer cell line. Darbre PD, Daly RJ (December 1990). "Transition of human breast cancer cells from an oestrogen responsive
Mir-129 microRNA precursor family (1,700 words) [view diff] exact match in snippet view article find links to article
the aberrant regulation of miR-129 contributes to the proliferation of cancer cell lines. SOX4 is involved in the mediation of transcription response to
LARP4 (617 words) [view diff] exact match in snippet view article find links to article
that LARP4 is involved in mRNA stability. LARP4 is known to regulate cancer cell migration and invasion by altering cell shape. It is also reported to
CARM1 (588 words) [view diff] exact match in snippet view article find links to article
arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate. 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743
Mucin short variant S1 (2,926 words) [view diff] exact match in snippet view article find links to article
also prevents the interaction of immune cells with receptors on the cancer cell surface through steric hindrance. This inhibits an anti-tumor immune
STEAP1 (484 words) [view diff] exact match in snippet view article find links to article
expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein
SMARCA4 (2,714 words) [view diff] exact match in snippet view article find links to article
ATPase in cancer. Mutations in this gene were first recognized in human cancer cell lines derived from adrenal gland and lung. Later it was recognized that
Mir-9/mir-79 microRNA precursor family (1,744 words) [view diff] no match in snippet view article find links to article
RM, Calin GA (2010). "MYC-microRNA-9-metastasis connection in breast cancer". Cell Res. 20 (6): 603–4. doi:10.1038/cr.2010.70. hdl:1822/67519. PMID 20502442
SK-OV-3 (447 words) [view diff] exact match in snippet view article find links to article
(also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with
P16 (4,271 words) [view diff] exact match in snippet view article find links to article
range of cancers, and alterations of the gene are frequently seen in cancer cell lines. Examples include: Pancreatic adenocarcinoma is often associated
Mir-200 (2,072 words) [view diff] exact match in snippet view article find links to article
colonization at distant tissues. In a series of mouse mammary isogenic cancer cell lines, the miR-200 family is highly expressed only in the cells that
Korea Research Institute of Bioscience and Biotechnology (356 words) [view diff] exact match in snippet view article find links to article
accomplishments include the development of a genome capable of controlling cancer cell proliferation and the identification of a neuropeptide Y-based growth
Axel Ullrich (913 words) [view diff] exact match in snippet view article find links to article
these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ultimately tumor shrinkage. In the early 1990s, Ullrich and
Secretomics (2,140 words) [view diff] exact match in snippet view article find links to article
cancer secretomics are cancer cell line supernatants and proximal biological fluids, the fluids in contact with a tumor. Cancer cell line supernatant is
Cadherin-2 (3,399 words) [view diff] exact match in snippet view article find links to article
cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the
Forkhead box C1 (1,682 words) [view diff] no match in snippet view article find links to article
Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer". Cell Reports. 13 (5): 1046–1058. doi:10.1016/j.celrep.2015.09.063. PMC 4806384
CDC42 (3,700 words) [view diff] exact match in snippet view article find links to article
attachment to endothelial cells as well. Knocking down β1 integrin inhibited cancer cell migration, whereas overexpressing the integrin in Cdc42-deficient cells
Perinucleolar compartment (1,123 words) [view diff] exact match in snippet view article find links to article
the prevalence is less than 5% in normal cell lines, but 15-100% in cancer cell lines. The PNC is directly proportional to metastasis as well as linked
Carcinoembryonic antigen peptide-1 (65 words) [view diff] exact match in snippet view article find links to article
carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small-cell lung. Synonyms:
Patellamide A (523 words) [view diff] exact match in snippet view article find links to article
show moderate cytotoxicity and activity against multidrug resistant cancer cell lines. Patellamide A was first isolated in 1981 from the tunicate L.
Cucurbitacin D (141 words) [view diff] exact match in snippet view article find links to article
it has shown inhibitory properties against endometrial and ovarian cancer cell lines. Enslin, P. R. (1954). "Bitter principles of the cucurbitaceae
Calu-3 (429 words) [view diff] exact match in snippet view article find links to article
Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory
Arachidonate 5-lipoxygenase (7,553 words) [view diff] exact match in snippet view article find links to article
of human cancer tumors in vivo as well as in various types of human cancer cell lines in vitro; these tumors and cell lines include those of the pancreas
Dihydroartemisinin (998 words) [view diff] exact match in snippet view article find links to article
discovered that artemisinin targets a broad spectrum of proteins in the human cancer cell proteome through heme-activated radical alkylation. Dihydroartemisinin
Exosome (vesicle) (7,573 words) [view diff] exact match in snippet view article
in biorepositories can be used for biomarker analysis as colorectal cancer cell-derived exosomes spiked into blood plasma could be recovered after 90
Rho-associated protein kinase (2,181 words) [view diff] exact match in snippet view article find links to article
along with MRCKα/β kinases have been implicated in the plasticity of cancer cell migration, the phenomenon which bestows survival advantage to the cancer
KBM-7 cells (688 words) [view diff] exact match in snippet view article find links to article
myelogenous leukemia (CML) cell line used for biomedical research. Like all cancer cell lines, it is immortal and can divide indefinitely. A unique aspect of
Cell adhesion molecule 1 (1,186 words) [view diff] exact match in snippet view article find links to article
"Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines". Jpn. J. Cancer Res. 93 (8): 857–60. doi:10.1111/j.1349-7006.2002
DACH1 (2,731 words) [view diff] exact match in snippet view article find links to article
tumors. DACH1 inhibits Cyclin D1 expression and thereby reduces breast cancer cell line cell growth. Normal cells and some breast cancer cells have receptors
George C. Prendergast (1,230 words) [view diff] case mismatch in snippet view article find links to article
research center in the U.S. He is also the co-director of the Program in Cancer Cell Biology & Signaling at the Sidney Kimmel Cancer Center, Thomas Jefferson
U0126 (743 words) [view diff] exact match in snippet view article find links to article
Cdk2 and Cdk4. The effects of U0126 on the growth of eight human breast cancer cell lines shown that U0126 selectively repressed anchorage-independent growth
PVT1 (1,037 words) [view diff] exact match in snippet view article find links to article
CpG island on its promoter region, promoting the suppression of the cancer cell apoptosis. Furthermore, activity of lncPVT1 and its associated microRNAs
Cruentaren (221 words) [view diff] exact match in snippet view article find links to article
yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro, including a multidrug-resistant KB line. Cruentaren B
KIF19 (132 words) [view diff] exact match in snippet view article find links to article
alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". doi:10.1101/2020.09.04.282657. S2CID 221589215. {{cite journal}}:
Mir-190 microRNA precursor family (521 words) [view diff] exact match in snippet view article find links to article
Yao Q, Chen C (April 2009). "Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis". World Journal
Phosphofructokinase 2 (4,253 words) [view diff] exact match in snippet view article find links to article
particularly implicated as being modified and hyper-expressed for prostate cancer cell survival. Because this enzyme family maintains rates of glycolysis and
MAP3K3 (1,820 words) [view diff] exact match in snippet view article find links to article
with colon and rectal cancers. MEKK3 is highly expressed in 4 ovarian cancer cell lines (OVCA429, Hey, DOV13, and SKOv3). This expression level is significantly
HEPACAM (1,060 words) [view diff] exact match in snippet view article find links to article
a) modulating cell-matrix adhesion and migration, and b) inhibiting cancer cell growth. (Note: *HEPACAM, gene name; **hepaCAM, protein name) Through
Fagonia (679 words) [view diff] exact match in snippet view article find links to article
much more effective than an aqueous extract at causing MCF-7 breast cancer cell death and inhibiting further cell multiplication. As of February 2025[update]
STAU1 (2,553 words) [view diff] exact match in snippet view article find links to article
dysregulation on cells and organs. STAU1 dysregulation may play a role in cancer cell development and progression. STAU1 has been associated with maintaining
GOT2 (1,683 words) [view diff] exact match in snippet view article find links to article
NADH into mitochondria to ensure a high rate of glycolysis in diverse cancer cell lines. In a study completed in 2008, inhibiting the malate-aspartate
Pyruvate dehydrogenase kinase (1,711 words) [view diff] exact match in snippet view article find links to article
cancerous cells. Similarly, PDK3 has been shown to be overexpressed in colon cancer cell lines. Three proposed inhibitors are AZD7545 and dichloroacetate which
Ferrocene (5,401 words) [view diff] exact match in snippet view article find links to article
inhibitory activity against human lung cancer cell line A549, colorectal cancer cell line HCT116, and breast cancer cell line MCF-7. An experimental drug was
Diane Barber (2,349 words) [view diff] exact match in snippet view article find links to article
and national scientific conferences. One focus of her research is on cancer cell biology, specifically in regards to the pHi (intracellular pH) of cancer
Calcium-binding mitochondrial carrier protein SCaMC-1 (370 words) [view diff] exact match in snippet view article find links to article
Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated
Period circadian protein homolog 1 (2,049 words) [view diff] exact match in snippet view article find links to article
circadian clock may play a large role in its likelihood of developing into a cancer cell. PER1 is a gene that plays an important role in such a circadian mechanism
Fangchinoline (112 words) [view diff] exact match in snippet view article find links to article
tetrandra. It has in vitro antiproliferative activity against a breast cancer cell line. Xie, Zhisheng; Xu, Xinjun; Xie, Chunyan; Liang, Zhikun; Yang, Mei;
TEAD1 (4,085 words) [view diff] exact match in snippet view article find links to article
complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression Moreover, VGLL2 interaction
Mir-126 (2,258 words) [view diff] exact match in snippet view article find links to article
is reduced in gastric cancer. mir-126 expression is reduced in lung cancer cell lines. mir-126 expression is reduced in prostate cancer and bladder cancer
COX7A2L (590 words) [view diff] exact match in snippet view article find links to article
This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents
CCR5 (4,539 words) [view diff] exact match in snippet view article find links to article
leronlimab have been shown to block lung metastasis of human breast cancer cell lines. In preclinical studies of immune competent mice CCR5 inhibitors
Alberto Bardelli (1,450 words) [view diff] case mismatch in snippet view article find links to article
of Individual Metastases during HER2 Blockade in Colorectal Cancer". Cancer Cell. 34 (1): 148–162.e7. doi:10.1016/j.ccell.2018.06.004. ISSN 1878-3686
Terry Speed (1,162 words) [view diff] exact match in snippet view article find links to article
(2006). "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes". Cancer Cell. 10 (6): 515–27. doi:10.1016/j.ccr
Actibind (1,363 words) [view diff] exact match in snippet view article find links to article
ACTIBIND Experiments in vitro Cancer Cell Colony Formation In order to determine the effects of ACTIBIND on cancer cell colony formation, a study done
Fangchinoline (112 words) [view diff] exact match in snippet view article find links to article
tetrandra. It has in vitro antiproliferative activity against a breast cancer cell line. Xie, Zhisheng; Xu, Xinjun; Xie, Chunyan; Liang, Zhikun; Yang, Mei;
Methylselenocysteine (532 words) [view diff] exact match in snippet view article find links to article
proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture." Apoptosis has been proposed as the most plausible
Marie Celeste Simon (303 words) [view diff] exact match in snippet view article find links to article
of Pennsylvania Perelman School of Medicine. Her research focuses on cancer cell metabolism, angiogenesis, and immunology. Simon earned a B.A. from Miami
TEAD1 (4,085 words) [view diff] exact match in snippet view article find links to article
complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression Moreover, VGLL2 interaction
ABCC5 (1,385 words) [view diff] exact match in snippet view article find links to article
of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Cancer Research. 57 (16): 3537–47. PMID 9270026. Suzuki T, Nishio
Degradome sequencing (2,432 words) [view diff] exact match in snippet view article find links to article
performed in two breast cancer cell lines in mice which were phenotypically distinct. One of these was a stem-cell like breast cancer cell line that altered
Torreyanic acid (1,096 words) [view diff] exact match in snippet view article find links to article
natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 μg/mL, ranging from 3.5 (NEC)
N-Myc (1,978 words) [view diff] case mismatch in snippet view article find links to article
of N-Myc is a critical function of Aurora A in human neuroblastoma". Cancer Cell. 15 (1): 67–78. doi:10.1016/j.ccr.2008.12.005. PMID 19111882. Gustafson
4-Hydroxybenzoic acid (1,925 words) [view diff] exact match in snippet view article find links to article
both in vitro and in vivo, and stimulates the growth of human breast cancer cell lines. It is a common metabolite of paraben esters, such as methylparaben
Betulinic acid (1,916 words) [view diff] exact match in snippet view article find links to article
C-3 phthalates derivatives exhibited higher cytotoxic activity against cancer cell lines with improved selective toxicity and water solubility. Chatterjee
Melipona scutellaris (2,412 words) [view diff] exact match in snippet view article find links to article
source of antibiofilm agents and to present selectivity against human cancer cell lines at low concentrations compared to normal cells. M. scutellaris
Rakesh Jain (704 words) [view diff] case mismatch in snippet view article find links to article
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell, 26: 605-22, 2014 Jain, RK. Normalizing tumor vasculature with anti-angiogenic
Inflammation (9,751 words) [view diff] exact match in snippet view article find links to article
mutagenic DNA damages. A normal cell may undergo carcinogenesis to become a cancer cell if it is frequently subjected to DNA damage during long periods of chronic
Piscarinine (159 words) [view diff] exact match in snippet view article find links to article
derivatives piscarinines A and B were shown to be active against the prostate cancer cell line LNCAP (IC50 values were 2.2 and 1.9 μg/mL for piscarinine A and
Dideoxyverticillin A (419 words) [view diff] exact match in snippet view article find links to article
exhibits antiangiogenic activity, and has efficacy against several cancer cell lines. Its reported anticancer mechanism is that it acts as a farnesyl
Gloiopeltis furcata (263 words) [view diff] exact match in snippet view article find links to article
show that extracts of G. furcata inhibit the growth of several human cancer cell lines, and can significantly lower blood glucose levels. G. furcata's
William H. Andrews (biologist) (1,052 words) [view diff] exact match in snippet view article
discovery, and the demonstration that the anti-sense of hTR could kill every cancer cell tested, Andrews and 3 members of his team were awarded second place for
PPM1D (1,172 words) [view diff] exact match in snippet view article find links to article
cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in
Berkeleydione (75 words) [view diff] exact match in snippet view article find links to article
isolated from a Penicillium species that has in vitro activity in a cancer cell line. It was first discovered in fungal species which evolved to live
Mothers against decapentaplegic homolog 4 (3,323 words) [view diff] exact match in snippet view article find links to article
(November 2007). "High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts
LZTS1 (546 words) [view diff] case mismatch in snippet view article find links to article
interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC 1987708. PMID 17349584
ERG (gene) (2,303 words) [view diff] exact match in snippet view article
oligonucleotides have been used to induce exon 4 skipping in prostate cancer cell lines, mouse models and tissue explants, leading to anti-cancer effects
TEAD2 (2,030 words) [view diff] exact match in snippet view article find links to article
complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression. The interaction between
SNP array (1,774 words) [view diff] exact match in snippet view article find links to article
DNA copy number profile for the T47D breast cancer cell line (Affymetrix SNP Array)
GPR158 (457 words) [view diff] exact match in snippet view article find links to article
androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation. GRCh38: Ensembl
MIR489 (557 words) [view diff] exact match in snippet view article find links to article
between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth". Oncotarget. 7 (14): 18295–308. doi:10
Danny Welch (531 words) [view diff] exact match in snippet view article find links to article
In 1996, Welch's lab in Hershey, Pennsylvania, isolated a cDNA from a cancer cell that was not able to undergo metastasis after the human chromosome 6
RNF14 (1,058 words) [view diff] exact match in snippet view article find links to article
inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327
Photopharmacology (3,771 words) [view diff] exact match in snippet view article find links to article
paper an in vitro protocol to test different light wavelengths on human cancer cell lines is developed, finding that blue light most effectively inhibited
U-87 MG (365 words) [view diff] exact match in snippet view article find links to article
"U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line". PLOS Genet. 6 (1): e1000832. doi:10.1371/journal.pgen.1000832
Atranorin (492 words) [view diff] exact match in snippet view article find links to article
August 2017). "The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis". Scientific Reports. 7 (1): 8136. Bibcode:2017NatSR
Merkel cell polyomavirus (4,234 words) [view diff] exact match in snippet view article find links to article
in 1972 as "trabecular tumor of the skin". Based on its origin, the cancer cell type is called a neuroectodermal tumor. Although rare compared with other
5-Oxo-eicosatetraenoic acid (4,378 words) [view diff] exact match in snippet view article find links to article
suggested that 5-oxo-ETE contributes to the development of inflammation, cancer cell growth, and other pathological and physiological events. In the most
MiR-296 (436 words) [view diff] case mismatch in snippet view article find links to article
growth factor receptor overexpression in angiogenic endothelial cells". Cancer Cell. 14 (5): 382–93. doi:10.1016/j.ccr.2008.10.005. PMC 2597164. PMID 18977327
Scott W. Lowe (950 words) [view diff] exact match in snippet view article find links to article
discovered mechanisms whereby senescence inducing therapies promote cancer cell immune surveillance. In 2015, Lowe continued his use of RNAi to study
Troglitazone (2,052 words) [view diff] exact match in snippet view article find links to article
novel troglitazone derivatives with antiproliferative activity in breast cancer cell lines. In 2009, Pfizer resolved all but three of 35,000 claims over its
Metastasis suppressor (1,578 words) [view diff] exact match in snippet view article find links to article
RHoGD12 is active in bladder cancer and inhibits proteins that aid in cancer cell migration. RhoGDI2 suppresses endothelin 1 (ET1), a vasoconstrictor correlated
Biosensor (12,175 words) [view diff] exact match in snippet view article find links to article
transferrin that would potentially attach to transferrin receptors on cancer cell surfaces. There is very high selectivity for transferrin receptors because
Cell cycle analysis (1,531 words) [view diff] exact match in snippet view article find links to article
effective DNA repair, which may prevent transformation of normal into a cancer cell (carcinogenesis), or to cell death, often by the mode of apoptosis. An
EMBiology (226 words) [view diff] case mismatch in snippet view article find links to article
gov) Tamoxifen has a positive "Clinical Trial" relationship with breast cancer Cell Expression Expression of proteins within or on the surface of a cell
Sarcosine dehydrogenase (1,589 words) [view diff] exact match in snippet view article find links to article
epithelial cells increases the concentration of sarcosine and increase cancer cell invasions while the removal of either dimethylglycine dehydrogenase or
P38 mitogen-activated protein kinases (1,385 words) [view diff] exact match in snippet view article find links to article
activity can activate genes that cause cancer cell survival, and can also activate genes that facilitate cancer cell metastasis to other tissues. P38 was
KLK9 (538 words) [view diff] exact match in snippet view article find links to article
skin. KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian and
P38 mitogen-activated protein kinases (1,385 words) [view diff] exact match in snippet view article find links to article
activity can activate genes that cause cancer cell survival, and can also activate genes that facilitate cancer cell metastasis to other tissues. P38 was
Carbon nanotubes in medicine (3,864 words) [view diff] exact match in snippet view article find links to article
multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Biological systems are known to be highly transparent to
Warburg effect (oncology) (3,011 words) [view diff] exact match in snippet view article
PMID 37922928. Alfarouk KO (December 2016). "Tumor metabolism, cancer cell transporters, and microenvironmental resistance". Journal of Enzyme Inhibition
PRDX3 (1,206 words) [view diff] exact match in snippet view article find links to article
that peroxiredoxin 3 is overexpressed in prostate cancer and promotes cancer cell survival by defending cells against the damages incurred by oxidative
ADGRL4 (443 words) [view diff] case mismatch in snippet view article find links to article
endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637
David Tuveson (2,337 words) [view diff] case mismatch in snippet view article find links to article
invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4:437-450 (2003) Hingorani, S.R., Wang, L., Multani, A.S., Combs, C
Immunohistochemistry (3,591 words) [view diff] exact match in snippet view article find links to article
typically from the spleen. The antibody producing cell is then fused with a cancer cell line. This causes the antibodies to show specificity for a single epitope
PAK4 (3,029 words) [view diff] exact match in snippet view article find links to article
implications in a number of disease conditions, exemplified by oncogenesis, cancer cell invasion and metastasis. PAK4 has been shown to interact with: CDC42
EGLN3 (856 words) [view diff] case mismatch in snippet view article find links to article
familial pheochromocytoma genes: developmental culling and cancer". Cancer Cell. 8 (2): 155–67. doi:10.1016/j.ccr.2005.06.015. PMID 16098468. Hopfer
Mothers against decapentaplegic homolog 3 (4,115 words) [view diff] exact match in snippet view article find links to article
angiogenesis. Studies analyzing SMAD3 levels of expression in prostate cancer cell lines found that the two androgen-independent and androgen receptor-negative
CREB-binding protein (5,272 words) [view diff] exact match in snippet view article find links to article
diseases, association of CBP with β-catenin has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads
Mir-615 microRNA precursor family (336 words) [view diff] exact match in snippet view article find links to article
pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma. Nasopharyngeal carcinoma-associated
KDM4A (1,569 words) [view diff] exact match in snippet view article find links to article
pathways such as p53. Suppression of Kdm4a in breast cancer cell lines has shown to reduce cancer cell proliferation through cell cycle arrest, and decrease
Simone Badal-McCreath (391 words) [view diff] exact match in snippet view article find links to article
creating the first cancer cell line from the Caribbean in 2022 during the COVID-19 pandemic. The intent was to create more cancer cell lines for black people
Australian Cancer Research Foundation (359 words) [view diff] exact match in snippet view article find links to article
Centre, Melbourne For new technologies to identify genes controlling cancer cell behaviour $2,500,000 QLD Institute for Molecular Bioscience, University
Epithelial cell adhesion molecule (2,451 words) [view diff] exact match in snippet view article find links to article
EpCAM in cancer tissue, where it is homogeneously distributed on the cancer cell surface. In addition to being overexpressed in many carcinomas, EpCAM
SLC45A3 (717 words) [view diff] exact match in snippet view article find links to article
significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3. There is
Drupanol (161 words) [view diff] exact match in snippet view article find links to article
"Bakuchiol inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity". Tianjin
P-selectin (2,589 words) [view diff] exact match in snippet view article find links to article
on a key role in metastasis of the tumor. However, in the 4T1 breast cancer cell line, E-selectin reactivity is sLe(x) dependent while P-selectin reactivity
Philadelphia chromosome (5,746 words) [view diff] case mismatch in snippet view article find links to article
through the inhibitory activity of the BCR/ABL-regulated SET protein". Cancer Cell. 8 (5): 355–368. doi:10.1016/j.ccr.2005.10.015. PMID 16286244. Trotta
Collagen, type XXIII, alpha 1 (1,559 words) [view diff] exact match in snippet view article find links to article
loss of collagen XXIII may complicate cellular adhesion and reduce lung cancer cell retention. Collagen Protein domain Transmembrane protein Non-small-cell
Azamulin (174 words) [view diff] exact match in snippet view article find links to article
S2CID 1866233. Mitra R, Goodman OB (April 2015). "CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR". The Prostate. 75
Tannishtha Reya (555 words) [view diff] exact match in snippet view article find links to article
publication in 2001 coining the term "cancer stem cell" to describe a cancer cell that mirrors the properties of stem cells of healthy organs in the context
Geminin (1,608 words) [view diff] exact match in snippet view article find links to article
S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNA interference results in re-replication
L-733,060 (1,038 words) [view diff] exact match in snippet view article find links to article
apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2". Investigational New Drugs. 26 (2): 111–8. doi:10.1007/s10637-007-9087-y
Itraconazole (2,483 words) [view diff] case mismatch in snippet view article find links to article
Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth". Cancer Cell. 17 (4): 388–99. doi:10.1016/j.ccr.2010.02.027. PMC 4039177. PMID 20385363
Mir-22 (791 words) [view diff] exact match in snippet view article find links to article
microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples". FEBS J. 277 (7): 1684–94. doi:10.1111/j
Cordycepin (1,853 words) [view diff] exact match in snippet view article find links to article
renal, colon, and breast cancer. Cordycepin reduces viable A549 lung cancer cell populations by 50%. By acting at RUVBL2, cordycepin is the most potent
RAD51 (5,526 words) [view diff] exact match in snippet view article find links to article
seen in BRCA1 deficiency), resulting in increased HRR that may enable cancer cell survival by partially ameliorating the excess of DNA damage. Under-expression
Mir-885 microRNA precursor family (820 words) [view diff] exact match in snippet view article find links to article
K. (2015-04-09). "MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking
NFKB1 (2,363 words) [view diff] case mismatch in snippet view article find links to article
"Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way". Cancer Cell. 3 (3): 201–2. doi:10.1016/S1535-6108(03)00049-7. PMID 12676577. Sun
Crotogoudin (63 words) [view diff] exact match in snippet view article find links to article
studies, it showed antiproliferative activity against various human cancer cell lines. Breitler, Simon; Carreira, Erick M. (2013). "Total Synthesis of
Gene set enrichment analysis (4,627 words) [view diff] no match in snippet view article find links to article
Gene set enrichment analysis (GSEA) (also called functional enrichment analysis or pathway enrichment analysis) is a method to identify classes of genes
Interleukin 30 (1,800 words) [view diff] exact match in snippet view article find links to article
tumor suppressor genes, IL-30 favors cancer cell proliferation, migration, and dissemination. That may boost cancer cell expression of cytokines and chemokines
Caffeic acid (2,070 words) [view diff] exact match in snippet view article find links to article
studies and in animal models, and the inhibitory effect of caffeic acid on cancer cell proliferation by an oxidative mechanism in the human HT-1080 fibrosarcoma
Joan Massagué (1,400 words) [view diff] case mismatch in snippet view article find links to article
"A multigenic program mediating breast cancer metastasis to bone". Cancer Cell. 3 (6): 537–49. doi:10.1016/s1535-6108(03)00132-6. PMID 12842083. Minn
LNCaP (1,754 words) [view diff] exact match in snippet view article find links to article
Keller ET (May 2001). "Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro" (PDF). Prostate. 47 (3): 212–21. doi:10.1002/pros
Cathepsin Z (1,784 words) [view diff] exact match in snippet view article find links to article
cellular adhesion and phagocytosis. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may
TNK2 (1,756 words) [view diff] case mismatch in snippet view article find links to article
Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer. Cancer Cell, 31(6), 790-803.e8. https://doi.org/10.1016/j.ccell.2017.05.003 ‌ GRCh38:
Devimistat (240 words) [view diff] exact match in snippet view article find links to article
on the tricarboxylic acid cycle and inhibiting enzymes involved with cancer cell energy metabolism. A lipoic acid derivative different from standard cytotoxic
SWI/SNF (3,947 words) [view diff] exact match in snippet view article find links to article
Early studies identified that SWI/SNF subunits were frequently absent in cancer cell lines. SWI/SNF was first identified in 1998 as a tumor suppressor in
P70-S6 Kinase 1 (2,099 words) [view diff] exact match in snippet view article find links to article
this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate
NKX3-1 (2,366 words) [view diff] exact match in snippet view article find links to article
androgen receptor-positive prostate cancer cell line, but was absent from androgen receptor-negative prostate cancer cell lines as well as other cell lines
Cadherin (3,588 words) [view diff] exact match in snippet view article find links to article
but also may affect signal transduction, leading to uncontrollable cancer cell growth. In epithelial cell cancers, disrupted cell-to-cell adhesion might
STK11 (2,791 words) [view diff] exact match in snippet view article find links to article
mediated by oestrogen receptor alpha. However, in ER-positive breast cancer cell line MCF-7, estradiol caused a dose-dependent decrease in LKB1 transcript
KIF20A (945 words) [view diff] exact match in snippet view article find links to article
trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell". Cancer Res. 65 (1): 105–12. doi:10.1158/0008-5472.105.65.1. PMID 15665285
Digital pathology (2,635 words) [view diff] exact match in snippet view article find links to article
chromatin, and therefore results in weak signals for the cancer cell output. These weak signals may result in a false positive result for a cancer cell.
KIF20A (945 words) [view diff] exact match in snippet view article find links to article
trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell". Cancer Res. 65 (1): 105–12. doi:10.1158/0008-5472.105.65.1. PMID 15665285
ACT Biotech Inc (272 words) [view diff] exact match in snippet view article find links to article
that targets cancer cells through multiple modes of action. It inhibits cancer cell growth by targeting the FGF receptor family, which are mutated in a number
Fusobacterium nucleatum (869 words) [view diff] exact match in snippet view article find links to article
and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration". doi:10.1101/2020.01.15.907931. S2CID 213030137. Retrieved
40S ribosomal protein S29 (846 words) [view diff] exact match in snippet view article find links to article
(February 2003). "Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis". Protein and
Genistin (754 words) [view diff] exact match in snippet view article find links to article
phytoestrogen as it was shown to stimulate estrogen-dependent breast cancer cell growth in vivo. At a concentration of 1200 ppm, genistin caused significant
7β-Hydroxyepiandrosterone (237 words) [view diff] exact match in snippet view article find links to article
7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines" (PDF). Steroids. 77 (5): 542–51. doi:10.1016/j.steroids.2012.01
6-Phosphogluconate dehydrogenase (538 words) [view diff] exact match in snippet view article find links to article
hereditary disease affecting the red blood cells. 6PGD is involved in cancer cell metabolism so 6PGD inhibitors have been sought. Parietin, a 6PGD inhibitor
Adecatumumab (243 words) [view diff] exact match in snippet view article find links to article
cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". British Journal of Cancer. 92 (2): 342–9. doi:10.1038/sj.bjc
CXCR4 (2,660 words) [view diff] case mismatch in snippet view article find links to article
"Tumor entrained neutrophils inhibit seeding in the premetastatic lung". Cancer Cell. 20 (3): 300–14. doi:10.1016/j.ccr.2011.08.012. PMC 3172582. PMID 21907922
Mike Berridge (biologist) (1,611 words) [view diff] exact match in snippet view article
(born 1946) is a New Zealand cell biologist. Since 1976, he has led the cancer cell and molecular biology research group at the Malaghan Institute of Medical
National Cancer Institute (3,029 words) [view diff] exact match in snippet view article find links to article
Biology DCB oversees approximately 2000 grants per year in the areas of cancer cell biology; cancer immunology, hematology, and etiology; DNA and chromosome
NCAPH (1,275 words) [view diff] exact match in snippet view article find links to article
supplementally, when NCAPH is depleted, studies show a decrease in colon cancer cell proliferation.  Studies show that high expression of NCAPH in colon cancer
Dostarlimab (3,237 words) [view diff] exact match in snippet view article find links to article
(30 July 2014), Diagram showing a monoclonal antibody attached to a cancer cell., archived from the original on 6 August 2022, retrieved 4 August 2022
Mir-16 microRNA precursor family (2,695 words) [view diff] case mismatch in snippet view article find links to article
Vecchione A (2008). "MicroRNA signatures in human ovarian cancer". Cancer Cell. 13 (3): 272–286. doi:10.1016/j.ccr.2008.02.013. PMID 18328430. Yanaihara
EIF3H (850 words) [view diff] exact match in snippet view article find links to article
Lehtonen HJ, Visakorpi T (2006). "Overexpression of EIF3S3 promotes cancer cell growth". Prostate. 66 (11): 1144–50. doi:10.1002/pros.20452. PMID 16652384
MTDH (1,727 words) [view diff] case mismatch in snippet view article find links to article
cell surface protein in breast tumors that mediates lung metastasis". Cancer Cell. 5 (4): 365–74. doi:10.1016/S1535-6108(04)00079-0. PMID 15093543. Sutherland
Fenbendazole (764 words) [view diff] exact match in snippet view article find links to article
"Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways". Scientific Reports.
Breast cancer classification (9,472 words) [view diff] exact match in snippet view article find links to article
the tumor, and the expression of proteins and genes. As knowledge of cancer cell biology develops these classifications are updated. The purpose of classification
Ron Laskey (593 words) [view diff] case mismatch in snippet view article find links to article
Professor Sir John Gurdon. In 2001, he founded the Medical Research Council Cancer Cell Unit in 2001, and was Director of the Unit until 2010. Laskey is also
HMBOX1 (452 words) [view diff] exact match in snippet view article find links to article
RNA-seq and ChIP-seq see little to no such effect at least in several cancer cell lines. GRCh38: Ensembl release 89: ENSG00000147421 – Ensembl, May 2017
Dichapetalins (175 words) [view diff] exact match in snippet view article find links to article
moieties. They have been found to display cytotoxicity against several cancer cell lines. Tuchinda, Patoomratana; Kornsakulkarn, Jittra; Pohmakotr, Manat;
Ras GTPase (4,042 words) [view diff] exact match in snippet view article find links to article
acid (FTS, Salirasib) exhibits profound anti-oncogenic effects in many cancer cell lines. Inappropriate activation of the gene has been shown to play a
Protease-activated receptor 2 (2,715 words) [view diff] exact match in snippet view article find links to article
KC, Xu W, Suen JY, Fairlie DP (November 2020). "PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR"
Antimetabolite (1,239 words) [view diff] exact match in snippet view article find links to article
antimetabolites have high cell cycle specificity and can target arrest of cancer cell DNA replication. Anthracyclines are anti-tumor antibiotics that interfere
PAC-1 (1,787 words) [view diff] exact match in snippet view article find links to article
sensitizes these cells to PAC-1-type compounds. Recent experiments using cancer cell lines with CRISPR deletion of CASP3 are also consistent with this result
Integrin beta 6 (4,724 words) [view diff] exact match in snippet view article find links to article
cancers with pharmaceuticals and functional imaging agents, such as cancer cell specific positron emission tomography (PET) imaging using the αvβ6-integrin
Mir-221 microRNA (2,794 words) [view diff] exact match in snippet view article find links to article
role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines". Cancer Res. 69 (8): 3356–63. doi:10.1158/0008-5472.CAN-08-4112
TACSTD2 (1,362 words) [view diff] exact match in snippet view article find links to article
deregulations at a transcriptional and posttranscriptional level. Trop-2 causes cancer cell growth, proliferation, invasion, migration, and survival of cancer cells
ERGIC2 (888 words) [view diff] exact match in snippet view article find links to article
formation in soft agar, and to decrease invasive potential of human prostate cancer cell line (PC-3 cells). It is now believed to be a chaperon molecule involved
Frizzled-8 (658 words) [view diff] exact match in snippet view article find links to article
canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer
Small nucleolar RNA SNORD93 (437 words) [view diff] exact match in snippet view article find links to article
snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion". npj Breast Cancer. 3: 25. doi:10.1038/s41523-017-0032-8. PMC 5503938
ABCB5 (1,864 words) [view diff] exact match in snippet view article find links to article
further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts
Pralatrexate (642 words) [view diff] case mismatch in snippet view article find links to article
Therapeutics' Pralatrexate Demonstrates Anticancer Activity in Multiple Cancer Cell Lines". [1], Memorial Sloan Kettering Cancer Center Press Release, "FDA
CST7 (gene) (865 words) [view diff] exact match in snippet view article
system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. GRCh38: Ensembl release 89:
RPN2 (1,248 words) [view diff] exact match in snippet view article find links to article
"Role of ribophorin II in the response to anticancer drugs in gastric cancer cell lines". Oncology Letters. 9 (4): 1861–1868. doi:10.3892/ol.2015.2900
DNA methyltransferase (3,598 words) [view diff] exact match in snippet view article find links to article
"Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation". Cancer Research. 66 (2): 729–35. doi:10
Pomiferin (921 words) [view diff] exact match in snippet view article find links to article
antimicrobial, antidiabetic, PDE5 inhibitor, and cytotoxicity for several cancer cell lines. Peterson and Fristad (2000) investigated folklore beliefs stating
Transcription factor Jun (5,537 words) [view diff] case mismatch in snippet view article find links to article
et al. (May 2007). "Rewired ERK-JNK signaling pathways in melanoma". Cancer Cell. 11 (5): 447–60. doi:10.1016/j.ccr.2007.03.009. PMC 1978100. PMID 17482134
Midostaurin (629 words) [view diff] case mismatch in snippet view article find links to article
leukemia cells by the small molecule tyrosine kinase inhibitor PKC412". Cancer Cell. 1 (5): 433–43. doi:10.1016/S1535-6108(02)00069-7. PMID 12124173.{{cite
SLC12A7 (451 words) [view diff] exact match in snippet view article find links to article
cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210
Pascal Mayer (815 words) [view diff] exact match in snippet view article find links to article
on cell lines, specific to cancer cells (no measurable effect on non-cancer cell lines), experiments carried out with EPFL. antibacterials based on IFRA
Radioligand (4,367 words) [view diff] exact match in snippet view article find links to article
is the target binding site, it may be on the surface of the targeted cancer cell for therapeutic purposes. Radioisotopes can occur naturally or be synthesized
Genetic marker (985 words) [view diff] no match in snippet view article find links to article
Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87. Gomez-Raya L, Olsen HG, Lingaas F, Klungland
Hydrazone (1,190 words) [view diff] exact match in snippet view article find links to article
targeted antibodies (see ADC), e.g. antibodies against a certain type of cancer cell. The hydrazone-based bond is stable at neutral pH (in the blood), but
Tumor microenvironment (7,014 words) [view diff] exact match in snippet view article find links to article
regulations are particularly important for tumor development and influence cancer cell growth, invasion, inflammation, and angiogenesis. CAFs may also exhibit
Palbociclib (3,587 words) [view diff] exact match in snippet view article find links to article
inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro". Breast Cancer Research. 11 (5): R77. doi:10.1186/bcr2419
UK Coronavirus Cancer Monitoring Project (4,522 words) [view diff] case mismatch in snippet view article find links to article
line protective measure for UK chemotherapy centres” Published report: Cancer Cell Dec 2020-July 2021, Paediatric cancer patients Headline findings: “children
Solasonine (540 words) [view diff] exact match in snippet view article find links to article
mitochondrial membrane permeability. Ferroptosis, a process that promotes cancer cell death, can be activated with solasonine by increasing and catalyzing
MMP11 (907 words) [view diff] exact match in snippet view article find links to article
S2CID 4266100. Boulay A, Masson R, Chenard MP, et al. (2001). "High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3
Catumaxomab (887 words) [view diff] exact match in snippet view article find links to article
dendritic cell via the heavy chains, an immunological reaction against the cancer cell is triggered. Removing cancer cells from the abdominal cavity reduces
Latrophilin 2 (576 words) [view diff] exact match in snippet view article find links to article
expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
KCNJ9 (658 words) [view diff] exact match in snippet view article find links to article
of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer. 5: 104. doi:10.1186/1471-2407-5-104. PMC 1208863
Pan-cancer analysis (1,144 words) [view diff] exact match in snippet view article find links to article
RBPs—NSUN6, ZC3H13, BYSL, ELAC1, RBMS3, and ZGPAT—in colorectal and liver cancer cell lines. Several studies have found a causal, predictable connection between
Glypican (2,445 words) [view diff] exact match in snippet view article find links to article
expression can be detected in normal ovarian cells; however, several ovarian cancer cell lines do not express GPC3. On the other hand, GPC3 expression is undetectable
Cylindrocyclophanes (1,067 words) [view diff] exact match in snippet view article find links to article
intriguing biological possibilities, especially its cytotoxicity to some cancer cell lines. Before the cylindrocyclophanes, the cyclophanes had all been produced
OLIG2 (3,206 words) [view diff] case mismatch in snippet view article find links to article
responses to genotoxic damage in neural progenitors and malignant glioma". Cancer Cell. 19 (3): 359–71. doi:10.1016/j.ccr.2011.01.035. PMC 3070398. PMID 21397859
Major vault protein (1,419 words) [view diff] exact match in snippet view article find links to article
"Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–1310. doi:10.1083/jcb.141
Hereditary leiomyomatosis and renal cell cancer syndrome (2,010 words) [view diff] case mismatch in snippet view article find links to article
between hereditary and sporadic type 2 papillary renal cell carcinoma". Cancer Cell. 20 (4): 511–523. doi:10.1016/j.ccr.2011.08.024. PMID 22014576. Yogev
Mouse mammary tumor virus (2,047 words) [view diff] exact match in snippet view article find links to article
distinct from endogenous retroviruses and are not detectable in breast cancer cell lines or biopsies". Virology. 318 (1): 393–404. doi:10.1016/j.virol.2003
SDHB (3,010 words) [view diff] case mismatch in snippet view article find links to article
dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase". Cancer Cell. 7 (1): 77–85. doi:10.1016/j.ccr.2004.11.022. PMID 15652751. MacKenzie
ATP-dependent Clp protease proteolytic subunit (1,548 words) [view diff] exact match in snippet view article find links to article
agents, including by the hyperactivation of ClpP to cause selective cancer cell lethality. Intracellular proteases have a role in bacterial virulence
Gammaretrovirus (2,341 words) [view diff] exact match in snippet view article find links to article
caused a controversy and eventual retraction. There were over 50 human cancer cell lines that were claimed to be linked to murine leukemia virus-related
Anna Perdrix Rosell (435 words) [view diff] exact match in snippet view article find links to article
Perdrix Rosell is a Spanish scientist who completed her PhD[when?] in cancer cell signalling at the Francis Crick Institute in London. She co-founded a
Emactuzumab (697 words) [view diff] case mismatch in snippet view article find links to article
macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy". Cancer Cell. 25 (6): 846–859. doi:10.1016/j.ccr.2014.05.016. PMID 24898549. Ries
GTP cyclohydrolase I (609 words) [view diff] exact match in snippet view article find links to article
potent, diffusable antioxidant that resists oxidative stress and enables cancer cell survival. Guanosine triphosphate (GTP) Tetrahydrobiopterin (THB, BH4)
MiR-203 (3,006 words) [view diff] exact match in snippet view article find links to article
where miR-203 is epigenetically silenced by hypermethylation. In lung cancer cell lines, miR-203 has been shown to target DKK1, a secreted protein which
Josef A. Käs (265 words) [view diff] exact match in snippet view article find links to article
recently (updated in the year of 2023), he has significantly contributed to cancer cell unjamming. Josef Alfons Käs studied at the Technische Universität München
Lonaprisan (193 words) [view diff] exact match in snippet view article find links to article
J, Haendler B (2011). "The antiprogestin Lonaprisan inhibits breast cancer cell proliferation by inducing p21 expression". Mol. Cell. Endocrinol. 333
Discovery and development of proton pump inhibitors (4,990 words) [view diff] exact match in snippet view article find links to article
occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance. Evidence emerged
Cadherin-1 (6,381 words) [view diff] exact match in snippet view article find links to article
found that EMT can happen in breast cancer cell lines with hypermethylation of CDH1 promoter, but in breast cancer cell lines with a CDH1 mutational inactivation
Galangin (464 words) [view diff] exact match in snippet view article find links to article
F.; Moussa, M.; Carroll, K. K. (1996). "Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus
Plicamycin (490 words) [view diff] exact match in snippet view article find links to article
Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor. One elucidated pathway shows
FOXP3 (3,448 words) [view diff] exact match in snippet view article find links to article
Foxp3 in melanoma,[citation needed] glioma, breast, prostate and ovarian cancer cell lines induces profound growth inhibitory effects in vitro and in vivo
DNAJB4 (489 words) [view diff] exact match in snippet view article find links to article
upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi:10.1038/sj.onc.1208573. PMID 15782117
ARHGAP5 (813 words) [view diff] exact match in snippet view article find links to article
the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion". Oncogene. 19 (10): 1318–28. doi:10.1038/sj.onc.1203422. PMID 10713673
Aurora kinase A (2,712 words) [view diff] exact match in snippet view article find links to article
BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines". Oncogene. 14 (18): 2195–2200. doi:10.1038/sj.onc.1201065. PMID 9174055
Fish hydrolysate (595 words) [view diff] exact match in snippet view article find links to article
'Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines', Process Biochemistry. Vol. 41, no. 5, May 2006. Brian Baker,
MDC1 (3,123 words) [view diff] exact match in snippet view article find links to article
Ser-15 residues necessary to p53 apoptotic activity. Studies on lung cancer cell lines (A549 cells) showed an increase in apoptosis in response to genotoxic
Navy bean (932 words) [view diff] exact match in snippet view article find links to article
antibacterial and anti-fungal activity, and have been found to inhibit cancer cell growth. Furthermore, navy beans are the richest source of ferulic acid
Simarouba glauca (517 words) [view diff] exact match in snippet view article find links to article
mechanisms leading to cancer cell death.[citation needed] Simarouba extracts are known to be effective only on specific types of human cancer cell lines and tests
Homogeneity and heterogeneity (1,515 words) [view diff] exact match in snippet view article find links to article
terms, by varying or different genes or alleles. In cancer research, cancer cell heterogeneity is thought to be one of the underlying reasons that make
Α-Hydroxyglutaric acid (764 words) [view diff] case mismatch in snippet view article find links to article
enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate". Cancer Cell. 17 (3): 225–34. doi:10.1016/j.ccr.2010.01.020. PMC 2849316. PMID 20171147
GDF11 (3,980 words) [view diff] exact match in snippet view article find links to article
and TNBC. GDF11 is also capable of inducing apoptosis in pancreatic cancer cell lines. However, In 130 patients with colorectal cancer (CRC), the expression
Hedgehog signaling pathway (6,910 words) [view diff] case mismatch in snippet view article find links to article
antifungal that inhibits Hedgehog pathway activity and cancer growth". Cancer Cell. 17 (4): 388–399. doi:10.1016/j.ccr.2010.02.027. PMC 4039177. PMID 20385363
Reverse transfection (961 words) [view diff] case mismatch in snippet view article find links to article
of live human cells". Nature Methods. 3 (5): 385–390. doi:10.1038/nmeth876. ISSN 1548-7091. Cancer Cell Lines and Primary Cells Retrieved 2011-10-14.
CRABP1 (1,447 words) [view diff] exact match in snippet view article find links to article
maze test and an object recognition task. CRABP1 is also involved in cancer cell apoptosis. trans-retinoic acid was considered a [null therapeutic target
Acanthamoeba (2,845 words) [view diff] exact match in snippet view article find links to article
extensively to understand the molecular biology of cell motility and cancer cell dormancy by in-depth exploration of the process of encystation. The recently
Cladosporium oxysporum (2,324 words) [view diff] exact match in snippet view article find links to article
T47D human breast cancer cell line, which suggested that the extract may exert its anti-proliferative effect on human breast cancer cell line by suppressing
Cell-mediated immunity (1,377 words) [view diff] exact match in snippet view article find links to article
Immunofluorescence micrograph of three cytotoxic T cells (outer three) surrounding a cancer cell. Lytic granules (red) are secreted at the contact site, killing the target
Ironomycin (599 words) [view diff] exact match in snippet view article find links to article
treatment of cancer. Ironomycin was shown to induce ferroptosis in breast cancer cell lines and its mechanism of action involves the targeting of lysosomal
GDF11 (3,980 words) [view diff] exact match in snippet view article find links to article
and TNBC. GDF11 is also capable of inducing apoptosis in pancreatic cancer cell lines. However, In 130 patients with colorectal cancer (CRC), the expression
Ironomycin (599 words) [view diff] exact match in snippet view article find links to article
treatment of cancer. Ironomycin was shown to induce ferroptosis in breast cancer cell lines and its mechanism of action involves the targeting of lysosomal
Mothers against decapentaplegic homolog 7 (2,851 words) [view diff] exact match in snippet view article find links to article
JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line". Cell. Signal. 21 (6): 892–8. doi:10.1016/j.cellsig.2009.01.034
Cell-mediated immunity (1,377 words) [view diff] exact match in snippet view article find links to article
Immunofluorescence micrograph of three cytotoxic T cells (outer three) surrounding a cancer cell. Lytic granules (red) are secreted at the contact site, killing the target
Nobiletin (386 words) [view diff] no match in snippet view article find links to article
efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell death & disease. 2022 Apr 19;13(4):374. Nobiletin[usurped], phytochemicals
Chromatin remodeling (5,523 words) [view diff] exact match in snippet view article find links to article
ATPase in cancer. Mutations in this gene were first recognized in human cancer cell lines derived from lung. In cancer, mutations in BRG1 show an unusually
Institute of Cancer Research (2,950 words) [view diff] exact match in snippet view article find links to article
significance in cancer research since cell motility is a key feature of cancer cell behaviour during metastasis (the spread of tumours around the human body)
O-GlcNAc (14,337 words) [view diff] exact match in snippet view article find links to article
treat Parkinson's disease. Dysregulation of O-GlcNAc is associated with cancer cell proliferation and tumor growth. O-GlcNAcylation of the glycolytic enzyme
CaBIG (2,648 words) [view diff] exact match in snippet view article find links to article
caBIG technology. In 2008, GlaxoSmithKline announced it would share cancer cell genomic data with caBIG. Some private companies claimed benefits from
ERCC1 (5,503 words) [view diff] exact match in snippet view article find links to article
repress translation or trigger degradation of target RNAs.) In breast cancer cell lines, almost one third (55/167) of miRNA promoters were targets for
Tetrahydrobiopterin (2,818 words) [view diff] exact match in snippet view article find links to article
potent, diffusable antioxidant that resists oxidative stress and enables cancer cell survival via promotion of angiogenesis. "Sapropterin (Kuvan) Use During
Punicic acid (300 words) [view diff] exact match in snippet view article find links to article
chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel". Invest New Drugs. 23 (2): 121–2. doi:10
Cancer-associated fibroblast (3,599 words) [view diff] exact match in snippet view article find links to article
angiogenesis, supporting the formation of tumours and thus proliferation of cancer cell and metastasis. Cancer cells are usually also drug resistant, which is
MSMB (2,098 words) [view diff] exact match in snippet view article find links to article
Pienta KJ (1993). "Effect of prostatic inhibin peptide (PIP) on prostate cancer cell growth in vitro and in vivo". Prostate. 22 (3): 225–33. doi:10.1002/pros
Crystal Mackall (3,269 words) [view diff] case mismatch in snippet view article find links to article
University. She is the founding director of the Stanford Center for Cancer Cell Therapy. Mackall grew up in East Palestine, Ohio in a working-class family;
UBE1L (662 words) [view diff] exact match in snippet view article find links to article
et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(2
ABHD6 (413 words) [view diff] exact match in snippet view article find links to article
alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Molecular Biology Reports. 36 (4): 691–6. doi:10.1007/s11033-008-9230-7
Estrogen receptor beta (4,526 words) [view diff] exact match in snippet view article find links to article
signaling has proliferative effects in both normal breast and breast cancer cell lines, whereas ERβ has generally antiproliferative effects in such cell
Oncogenomics (7,684 words) [view diff] exact match in snippet view article find links to article
tumor cells. Research has used mitochondrial mutations as biomarkers for cancer cell therapy. It is easier to target mutation within mitochondrial DNA versus
KLF4 (6,966 words) [view diff] exact match in snippet view article find links to article
(May 2003). "Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity". Oncogene. 22 (22): 3424–3430
DNMT3B (1,443 words) [view diff] exact match in snippet view article find links to article
(August 2002). "An essential role for DNA methyltransferase DNMT3B in cancer cell survival". The Journal of Biological Chemistry. 277 (31): 28176–81. doi:10
FreeLife (932 words) [view diff] exact match in snippet view article find links to article
were unfounded and based only on preliminary laboratory research on cancer cell inhibition, a finding that was never confirmed in other laboratory or
Zinc transporter ZIP6 (535 words) [view diff] exact match in snippet view article find links to article
oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0
Tumor metabolome (2,581 words) [view diff] exact match in snippet view article find links to article
progression of a tumor. In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed
Glutaminolysis (1,516 words) [view diff] exact match in snippet view article find links to article
"Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines". Cancer Research. 54 (22): 5974–5980. PMID 7954430. Spittler,
Portentol (400 words) [view diff] exact match in snippet view article find links to article
various other lichen. It has exhibited moderate activity toward several cancer cell lines. Of greater interest is the structural skeleton and chemical space
Tetrandrine (761 words) [view diff] exact match in snippet view article find links to article
anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402". Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal
Byssus (1,696 words) [view diff] exact match in snippet view article find links to article
"Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy". Nanomedicine. 8 (1): 17–28
Bcl-xL (884 words) [view diff] exact match in snippet view article find links to article
from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line". BMC Cancer. 6 (213): 213. doi:10.1186/1471-2407-6-213. PMC 1560389
KMT2C (958 words) [view diff] exact match in snippet view article find links to article
"Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation". British Journal
TRPM8 (3,255 words) [view diff] exact match in snippet view article find links to article
in many prostate cancer cell lines and Dendreon/Genentech are pursuing an agonist approach to induce apoptosis and prostate cancer cell death. TRPM8 channels
Mir-10 microRNA precursor family (3,499 words) [view diff] no match in snippet view article find links to article
PMID 17355992. Lund AH (February 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58.
MSH2 (4,237 words) [view diff] no match in snippet view article find links to article
deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer". Cell. 82 (2): 321–30. doi:10.1016/0092-8674(95)90319-4. PMID 7628020. S2CID 7954019
HIC1 (900 words) [view diff] case mismatch in snippet view article find links to article
loss of Hic1 function accentuates the role of p53 in tumorigenesis". Cancer Cell. 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761. Britschgi
Mir-31 (1,275 words) [view diff] exact match in snippet view article find links to article
factor p53, responsible for encoding the tumour suppressor protein p53. Cancer cell lines with an inactive p53 pathway show a vulnerability to miR-31 overexpression
Carmofur (837 words) [view diff] exact match in snippet view article find links to article
a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor
INH1 (139 words) [view diff] exact match in snippet view article find links to article
consequently cancer cell apoptosis. Experiments show that INH1 potently inhibits the proliferation of multiple human breast cancer cell lines, cervical
Bruce Ponder (2,405 words) [view diff] exact match in snippet view article find links to article
showed that a cancer mutation could confer an advantage, so that a future cancer cell would outcompete surrounding normal cells, and moreover that this advantage
Prenylflavonoid (1,010 words) [view diff] exact match in snippet view article find links to article
effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines". Food and Chemical Toxicology. 37 (4): 271–85. doi:10.1016/S0278-6915(99)00019-8
TOX3 (767 words) [view diff] exact match in snippet view article find links to article
Chen W, Qin H, Diao W, Li B, Cao W, et al. (May 2019). "TOX3 inhibits cancer cell migration and invasion via transcriptional regulation of SNAI1 and SNAI2
Mir-31 (1,275 words) [view diff] exact match in snippet view article find links to article
factor p53, responsible for encoding the tumour suppressor protein p53. Cancer cell lines with an inactive p53 pathway show a vulnerability to miR-31 overexpression
Prenylflavonoid (1,010 words) [view diff] exact match in snippet view article find links to article
effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines". Food and Chemical Toxicology. 37 (4): 271–85. doi:10.1016/S0278-6915(99)00019-8
SULF1 (6,584 words) [view diff] exact match in snippet view article find links to article
specifically required for cisplatin-induced apoptosis of the ovarian cancer cell line, OV207. The mechanism by which Sulf1 is downregulated in ovarian
Magnetic nanoring (1,586 words) [view diff] exact match in snippet view article find links to article
body, as well as a clearer image of tumors by improving accuracy of cancer cell identification. They also allow for a more efficient and smaller, MRAM
PKM2 (4,865 words) [view diff] exact match in snippet view article find links to article
phosphate donor. Many of these proteins contribute to the regulation of cancer cell proliferation. Specifically, PKM2 can be a component in mitogen-activated
BCAR3 (943 words) [view diff] exact match in snippet view article find links to article
anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". J. Cell. Physiol. 212 (3): 655–65. doi:10.1002/jcp.21059
Bombesin (723 words) [view diff] exact match in snippet view article find links to article
cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines". Scandinavian Journal of Gastroenterology. 34 (12): 1224–9. doi:10
CMP-sialic acid transporter (642 words) [view diff] exact match in snippet view article find links to article
"Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110)". Biochem. Biophys
Hypericum adenotrichum (221 words) [view diff] exact match in snippet view article find links to article
into for its anti-cancer properties, including slowing the growth of cancer cell lines. "Hypericum adenotrichum Spach". ipni.org. International Plant
Quorum sensing (11,070 words) [view diff] exact match in snippet view article find links to article
host and pathogenic bacteria. Quorum sensing may also be useful for cancer cell communications. In addition to its function in biological systems, quorum
IQGAP1 (3,922 words) [view diff] exact match in snippet view article find links to article
Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines and its over-expression and distinct membrane localisation is also
Colon cancer associated transcript 1 (658 words) [view diff] exact match in snippet view article find links to article
promotes tumor formation and is upregulated in colon cancer and other cancer cell types. This transcript may regulate long range chromosomal interactions
Susmita Bose (1,322 words) [view diff] exact match in snippet view article find links to article
developed ways to deliver curcumin and other natural compounds to stop bone cancer cell growth without inhibiting healthy bone cells. That same year, she was
Laura Machesky (456 words) [view diff] exact match in snippet view article find links to article
Professor of Biochemistry. Machesky's research group specialises in cancer cell migration, invasion, metastasis and the energetics of cell biology. She
Diketopiperazine (413 words) [view diff] exact match in snippet view article find links to article
methicillin-resistant Staphylococcus aureus (MRSA), in addition to four different human cancer cell lines in vitro. As antivirals, however, DPKs appear to have a poor outlook
Diallyl trisulfide (866 words) [view diff] exact match in snippet view article find links to article
appear to contribute to the apoptosis of cancer cells and a decrease in cancer cell proliferation. DATS can be metabolized by glutathione in red blood cells
Bioelectronics (1,483 words) [view diff] exact match in snippet view article find links to article
Bioelectronics could be used to develop new label-free methods for monitoring cancer cell invasion and drug resistance. For example, the electrical resistance
Cynaropicrin (2,769 words) [view diff] exact match in snippet view article find links to article
kinase (ERK). Research shows that it had a pro-apoptotic activity on cancer cell lines U937, Eol-1 and Jurkat T cells. Its cytotoxic activity was inhibited
Menerba (1,115 words) [view diff] exact match in snippet view article find links to article
proliferative genes, c-myc and cyclin D1, or stimulate MCF-7 breast cancer cell proliferation or tumor formation, demonstrating that it may be a viable
Demethylase (3,087 words) [view diff] no match in snippet view article find links to article
subunit of the NuRD complex and targets the metastasis programs in breast cancer". Cell. 138 (4): 660–72. doi:10.1016/j.cell.2009.05.050. PMID 19703393. Ciccone
Alpha-1D adrenergic receptor (1,214 words) [view diff] exact match in snippet view article find links to article
Kyprianou N, Benning CM (August 2000). "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via
Pachypodol (189 words) [view diff] exact match in snippet view article find links to article
leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro". Phytotherapy Research. 22 (12): 1684–1687. doi:10.1002/ptr
MTA1 (3,836 words) [view diff] exact match in snippet view article find links to article
as a differentially expressed gene in a highly metastatic rat breast cancer cell line. The role in MTA1 in chromatin remodeling was deduced due to the
Fyn-related kinase (575 words) [view diff] exact match in snippet view article find links to article
PMC 139241. PMID 12477932. Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int
Mitogen (1,727 words) [view diff] case mismatch in snippet view article find links to article
progression in the absence of pocket protein activity". December 2005, Cancer Cell, Vol. 8, pp. 455-466 Gemberling et al. "Nrg1 is an injury-induced cardiomyocyte
Free fatty acid receptor 1 (7,458 words) [view diff] exact match in snippet view article find links to article
of cultured cancer cells. These malignant behaviors include cultured cancer cell motility and proliferation which are regarded as being related to the
WAY-200070 (465 words) [view diff] exact match in snippet view article find links to article
treatment with tamoxifen and estrogen receptor β agonists on human breast cancer cell lines". Arch. Gynecol. Obstet. 289 (1): 163–71. doi:10.1007/s00404-013-2977-7
Pancreatic stellate cell (2,538 words) [view diff] exact match in snippet view article find links to article
cytokines, ECM and angiogenic responses in PaSCs, which in turn induce cancer cell proliferation. Matri-cellular proteins may therefore directly contribute
CpG island hypermethylation (1,148 words) [view diff] exact match in snippet view article find links to article
considered as an incomplete scenario, despite the idea of the genome of the cancer cell undergoing a reduction of its 5-methylcytosine content when compared
Igor Stagljar (1,667 words) [view diff] exact match in snippet view article find links to article
Sciences in Split (Croatia). He is an expert in the field of proteomics, cancer cell signalling and COVID-19 serological testing.[citation needed] He received
KLK11 (974 words) [view diff] exact match in snippet view article find links to article
"Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". Prostate. 49 (1): 72–8. doi:10.1002/pros.1119. PMID 11550212
Citric acid cycle (6,095 words) [view diff] exact match in snippet view article find links to article
a terminal metabolite as isotope labelling experiments of colorectal cancer cell lines show that its conversion back to alpha-ketoglutarate is too low
Who's Afraid of Peer Review? (2,208 words) [view diff] exact match in snippet view article find links to article
template is "Molecule X from lichen species Y inhibits the growth of cancer cell Z". He created a database of molecules, lichens, and cancer cells to
IGFBP6 (981 words) [view diff] exact match in snippet view article find links to article
SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer. 29A (11): 1578–84. doi:10
60S ribosomal protein L11 (1,160 words) [view diff] case mismatch in snippet view article find links to article
(2004). "Regulation of HDM2 activity by the ribosomal protein L11". Cancer Cell. 3 (6): 577–587. doi:10.1016/S1535-6108(03)00134-X. PMID 12842086. Odintsova
KMT2D (3,946 words) [view diff] exact match in snippet view article find links to article
and TNFRSF14. Conversely, KMT2D deficiency in several breast and colon cancer cell lines leads to reduced proliferation. Increased KMT2D was shown to facilitate
Alpha-7 nicotinic receptor (2,869 words) [view diff] exact match in snippet view article find links to article
to be involved in cancer progression. They have been shown to mediate cancer cell proliferation and metastasis. α7 receptors are also involved in angiogenic
Somatostatin receptor 3 (1,190 words) [view diff] exact match in snippet view article find links to article
somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology. 7 (3): 91–8. doi:10.1016/S1078-1439(01)00173-9
Bafilomycin (4,672 words) [view diff] exact match in snippet view article find links to article
subsequent induction of apoptosis in osteosarcoma cells as well as other cancer cell lines. Bafilomycin acts as an ionophore, meaning it can transfer K+ ions
Decoy receptor 1 (992 words) [view diff] exact match in snippet view article find links to article
expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to
Elesclomol (650 words) [view diff] exact match in snippet view article find links to article
Kepros J, Yang CY, Zhang M, et al. (August 2008). "Elesclomol induces cancer cell apoptosis through oxidative stress". Molecular Cancer Therapeutics. 7
Psychoactive plant (796 words) [view diff] exact match in snippet view article find links to article
predators. As explained in the next section, phytochemicals inhibit cancer cell growth, boost the immune system, and prevent damage to DNA that can lead
ASCL2 (1,242 words) [view diff] exact match in snippet view article find links to article
previously been demonstrated. ASCL2 expression was noted in multiple breast cancer cell lines, most notably in MCF7 cells. siRNA KO of ASCL2 was shown to inhibit
Minichromosome maintenance (3,042 words) [view diff] exact match in snippet view article find links to article
vivo especially in certain types of cancer cell lines. The association between MCMs and proliferation in cancer cell lines is mostly attributed to its ability
EMSY (732 words) [view diff] no match in snippet view article find links to article
2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.
ZNF423 (920 words) [view diff] case mismatch in snippet view article find links to article
acid-induced differentiation and is a marker of neuroblastoma outcome". Cancer Cell. 15 (4): 328–40. doi:10.1016/j.ccr.2009.02.023. PMC 2693316. PMID 19345331
Ekpoma virus (738 words) [view diff] exact match in snippet view article find links to article
broad cellular tropism and the ability to infect a wide range of human cancer cell lines.  Neither virus has been isolated, hindering research. EKV-1 and