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Longer titles found: Lanosterol 14 alpha-demethylase (view), Sterol 14-demethylase (view), Cytochrome P450 aromatic O-demethylase (view), (Histone-H3)-lysine-36 demethylase (view), Thebaine 6-O-demethylase (view), Histone demethylase (view), Codeine 3-O-demethylase (view), 7-Methylxanthine demethylase (view), DNA oxidative demethylase (view), AlkB homolog 5, RNA demethylase (view)

searching for Demethylase 176 found (248 total)

alternate case: demethylase

Oxiconazole (143 words) [view diff] no match in snippet view article find links to article

Oxiconazole (trade names Oxistat in the US, Oxizole in Canada) is an antifungal medication typically administered in a cream or lotion to treat skin infections

Miconazole (1,121 words) [view diff] exact match in snippet view article find links to article

hypoglycaemia (low blood sugar) Miconazole inhibits the fungal enzyme 14α-sterol demethylase, resulting in a reduced production of ergosterol. In addition to its

KDM5C (855 words) [view diff] exact match in snippet view article find links to article

Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene. KDM5C belongs to the alpha-ketoglutarate-dependent hydroxylase

Bifonazole (486 words) [view diff] no match in snippet view article find links to article

Bifonazole (trade name Canespor among others) is an imidazole antifungal drug used in form of ointments. It was patented in 1974 and approved for medical

Chlormidazole (55 words) [view diff] no match in snippet view article find links to article

Chlormidazole (INN, also known as clomidazole) is used as a spasmolytic and azole antifungal drug. Clemizole Krasiejko I, Gajewicz L, Lipnicki D (1990)

KDM5D (1,083 words) [view diff] exact match in snippet view article find links to article

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene. KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases

Butoconazole (97 words) [view diff] no match in snippet view article find links to article

Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology. It is administered as a vaginal cream. Seidman LS, Skokos

Tioconazole (242 words) [view diff] no match in snippet view article find links to article

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast. It is marketed under the brand names

KDM1A (2,086 words) [view diff] exact match in snippet view article find links to article

Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A

Omoconazole (100 words) [view diff] no match in snippet view article find links to article

Omoconazole is an azole antifungal drug. Omonocazole is not available in the United States and Canada. In other countries, it is used to treat cutaneous

Croconazole (61 words) [view diff] no match in snippet view article find links to article

Croconazole (INN) is an imidazole antifungal. Pfaller MA (2010). "Chapter 143: Croconazole". In Turner A (ed.). Logan Turner's Diseases of the Nose, Throat

Luliconazole (125 words) [view diff] no match in snippet view article find links to article

Luliconazole, trade names Luzu among others, is an imidazole antifungal medication. As a 1% topical cream, It is indicated for the treatment of athlete's

Fluconazole (2,817 words) [view diff] exact match in snippet view article find links to article

cytochrome P450 enzyme 14α-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents

KDM3B (650 words) [view diff] exact match in snippet view article find links to article

Lysine-specific demethylase 3B is an enzyme that in humans is encoded by the KDM3B gene. KDM3B belongs to the alpha-ketoglutarate-dependent hydroxylase

Sulconazole (132 words) [view diff] no match in snippet view article find links to article

Sulconazole (trade name Exelderm) is an antifungal medication of the imidazole class. It is available as a cream or solution to treat skin infections such

Sertaconazole (570 words) [view diff] exact match in snippet view article find links to article

sertaconazole blocks the synthesis of ergosterol by inhibiting the 14α-demethylase enzyme. Ergosterol is a critical component of the fungal cell membrane

Ravuconazole (182 words) [view diff] no match in snippet view article find links to article

Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007. The drug has shown

Econazole (405 words) [view diff] no match in snippet view article find links to article

Econazole is an antifungal medication of the imidazole class. It was patented in 1968, and approved for medical use in 1974. Econazole is used as a cream

Clotrimazole (1,454 words) [view diff] exact match in snippet view article find links to article

fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. Clotrimazole may slow fungal growth or result in fungal cell death.

Eberconazole (194 words) [view diff] no match in snippet view article find links to article

Eberconazole is an antifungal drug. As a 1% topical cream, it is an effective treatment for dermatophytosis, candidiasis, and pityriasis. It was approved

Neticonazole (118 words) [view diff] no match in snippet view article find links to article

Neticonazole (INN) is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is only approved for use in Japan. It is sold as

Albaconazole (98 words) [view diff] no match in snippet view article find links to article

Albaconazole (development code UR-9825) is an experimental triazole antifungal. It has potential broad-spectrum activity. The drug blocks a number of CYP450

Isoconazole (218 words) [view diff] no match in snippet view article find links to article

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria. For foot and vaginal infections, isoconazole has a similar effectiveness

Voriconazole (1,166 words) [view diff] no match in snippet view article find links to article

Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis

Fenticonazole (357 words) [view diff] no match in snippet view article find links to article

Fenticonazole is an imidazole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of

Bisantrene (1,743 words) [view diff] exact match in snippet view article find links to article

which is a m6A RNA demethylase. The same study found that bisantrene is a weak inhibitor of ALKBH5, which is the only other demethylase, i.e. bisantrene

Enilconazole (575 words) [view diff] no match in snippet view article find links to article

Enilconazole (synonyms imazalil, chloramizole) is a fungicide widely used in agriculture, particularly in the growing of citrus fruits. Trade names include

Terconazole (1,964 words) [view diff] no match in snippet view article find links to article

Terconazole is an antifungal drug used to treat vaginal yeast infection. It comes as a lotion or a suppository and disrupts the biosynthesis of fats in

Hexaconazole (78 words) [view diff] no match in snippet view article find links to article

Hexaconazole is a broad-spectrum systemic triazole fungicide used for the control of many fungi particularly Ascomycetes and Basidiomycetes. Major consumption

Fosfluconazole (205 words) [view diff] no match in snippet view article find links to article

Fosfluconazole (INNTooltip International Nonproprietary Name) is a water-soluble phosphate prodrug of fluconazole — a triazole antifungal drug used in

Isavuconazonium (1,437 words) [view diff] exact match in snippet view article find links to article

isavuconazole. Isavuconazole works by inhibition of lanosterol 14α-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation

UTX (gene) (823 words) [view diff] exact match in snippet view article

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded

Levoketoconazole (432 words) [view diff] exact match in snippet view article find links to article

(cholesterol side-chain cleavage enzyme) and CYP51A1 (lanosterol-14α-demethylase), similarly but more potently relative to ketoconazole. "FDA-sourced

Tebuconazole (198 words) [view diff] no match in snippet view article find links to article

Tebuconazole is a triazole fungicide used agriculturally to treat plant pathogenic fungi. Though the U.S. Food and Drug Administration considers this fungicide

Oteseconazole (805 words) [view diff] exact match in snippet view article find links to article

orally bioavailable and selective inhibitor of fungal lanosterol 14α-demethylase (CYP51), has shown promising efficacy in the treatment of recurrent vulvovaginal

Ketoconazole (4,376 words) [view diff] exact match in snippet view article find links to article

ketoconazole works principally by inhibiting the enzyme cytochrome P450 14α-demethylase (CYP51A1). This enzyme participates in the sterol biosynthesis pathway

Pramiconazole (58 words) [view diff] no match in snippet view article find links to article

Pramiconazole is a triazole antifungal which was under development by Barrier Therapeutics for the treatment of acute skin and mucosal fungal infections

KDM4B (593 words) [view diff] exact match in snippet view article find links to article

Lysine-specific demethylase 4B is an enzyme that in humans is encoded by the KDM4B gene. KDM4B belongs to the alpha-ketoglutarate-dependent hydroxylase

KDM4D (410 words) [view diff] exact match in snippet view article find links to article

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene. KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase

HR (gene) (1,145 words) [view diff] exact match in snippet view article

MUHH, MUHH1, hair growth associated, lysine demethylase and nuclear receptor corepressor, HR lysine demethylase and nuclear receptor corepressor External

Econazole/triamcinolone (71 words) [view diff] no match in snippet view article find links to article

Econazole/triamcinolone is a combination drug, consisting of econazole (an imidazole antifungal) and triamcinolone (a group III topical steroid). It is

Uniconazole (293 words) [view diff] no match in snippet view article find links to article

Uniconazole is a triazole chemical used as a plant growth retardant. It is active on a wide range of plants and acts by inhibiting the production of gibberellins

GFI1 (1,436 words) [view diff] exact match in snippet view article find links to article

promoter region and is dependent on Gfi1’s interaction with the histone demethylase LSD1. Gfi1 represses PU.1, and this repression precedes and correlates

Vanillate monooxygenase (195 words) [view diff] exact match in snippet view article find links to article

names in common use include 4-hydroxy-3-methoxybenzoate demethylase, and vanillate demethylase. This enzyme participates in 2,4-dichlorobenzoate degradation

KDM2B (1,477 words) [view diff] exact match in snippet view article find links to article

The human KDM2B gene encodes the protein lysine (K)-specific demethylase 2B. KDM2B is broadly and highly expressed in embryonic tissues (especially in

KDM3A (229 words) [view diff] exact match in snippet view article find links to article

Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene. This gene encodes a zinc finger protein that contains a jumonji C (JmjC)

Sarcosine dehydrogenase (1,589 words) [view diff] exact match in snippet view article find links to article

oxidoreductase (demethylating). Other names in common use include sarcosine N-demethylase, monomethylglycine dehydrogenase, and sarcosine:(acceptor) oxidoreductase

N-methyl-L-amino-acid oxidase (192 words) [view diff] exact match in snippet view article find links to article

and demethylase. Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658. Moritani M (1952). "Demethylase. V

Dihydrolanosterol (124 words) [view diff] exact match in snippet view article find links to article

sterol 14alpha-demethylase. Lanosterol Obtusifoliol Cycloartenol Lepesheva, GI; Waterman, MR (March 2007). "Sterol 14alpha-demethylase cytochrome P450

KDM7A (140 words) [view diff] exact match in snippet view article find links to article

Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene. GRCh38: Ensembl release 89: ENSG00000006459 – Ensembl, May 2017 GRCm38:

UTY (gene) (683 words) [view diff] exact match in snippet view article

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene. This gene encodes a protein containing tetratricopeptide repeats which

H-Y antigen (664 words) [view diff] exact match in snippet view article find links to article

later identified as an 11-residue peptide from the Lysine-Specific Demethylase 5D protein (KDM5D gene) presented by HLA-B7. A third example is MEA1

Eburicol (78 words) [view diff] exact match in snippet view article find links to article

sterol 14alpha-demethylase ERG11. Aoyama, Y; Yoshida, Y (15 August 1991). "Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of

Β-Sitosterol (1,387 words) [view diff] exact match in snippet view article find links to article

sterol C-14 demethylase (E4), sterol Δ14-reductase (E5), and sterol Δ8-Δ7-isomerase (E6). The last methyl group is removed by sterol demethylase (E7) to form

Cyproconazole (1,546 words) [view diff] no match in snippet view article find links to article

Cyproconazole is an agricultural fungicide of the class of azoles, used on cereal crops, coffee, sugar beet, fruit trees and grapes, and peanuts, on sod

MiR-137 (2,115 words) [view diff] exact match in snippet view article find links to article

miRecords database. Among these targets, LSD1 (Lysine-specific histone demethylase 1A, also known as KDM1A) has been shown to be directly downregulated

X-linked intellectual disability (2,017 words) [view diff] exact match in snippet view article find links to article

X-linked intellectual disability and epilepsy. KDM5C: Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene a member

Trimethylamine-oxide aldolase (141 words) [view diff] exact match in snippet view article find links to article

formaldehyde-lyase, trimethylamine N-oxide aldolase, trimethylamine N-oxide demethylase, and trimethylamine-N-oxide formaldehyde-lyase. This enzyme participates

N6-methyl-lysine oxidase (149 words) [view diff] exact match in snippet view article find links to article

oxidoreductase, N6-methyllysine oxidase, epsilon-N-methyllysine demethylase, epsilon-alkyllysinase, and 6-N-methyl-L-lysine:oxygen oxidoreductase

Steroidogenesis inhibitor (2,107 words) [view diff] exact match in snippet view article find links to article

are currently under investigation for such indications. Lanosterol 14α-demethylase (CYP51A1) inhibitors such as clotrimazole, fluconazole, itraconazole

Antifungal (2,630 words) [view diff] exact match in snippet view article find links to article

conversion of lanosterol to ergosterol by inhibiting lanosterol 14α-demethylase. These compounds have a five-membered ring containing two or three nitrogen

Alkb homolog 1, histone h2a dioxygenase (584 words) [view diff] exact match in snippet view article find links to article

Seeberg E, Krokan HE (February 2003). "Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA". Nature. 421 (6925): 859–63

HEMGN (815 words) [view diff] exact match in snippet view article find links to article

This regulation is dependent on Gfi1's interaction with the histone demethylase LSD1. The key interaction mechanisms are as follows: Gfi1 activates Hemgn

Obtusifoliol (77 words) [view diff] exact match in snippet view article find links to article

2011). "Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans". Archives of Biochemistry and Biophysics

Potyviridae (806 words) [view diff] exact match in snippet view article find links to article

Wang, Haijuan; Pasin, Fabio; Zhao, Mingmin (October 2022). "AlkB RNA demethylase homologues and N6 -methyladenosine are involved in Potyvirus infection"

JARID2 (1,137 words) [view diff] exact match in snippet view article find links to article

regulatory region sequence-specific DNA binding chromatin binding histone demethylase activity DNA-binding transcription repressor activity, RNA polymerase

RCOR1 (1,128 words) [view diff] exact match in snippet view article find links to article

C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6): 857–64. doi:10

RIOX2 (575 words) [view diff] exact match in snippet view article find links to article

histone demethylase activity identical protein binding histone H3-methyl-lysine-4 demethylase activity histone H3-methyl-lysine-36 demethylase activity

Vafidemstat (427 words) [view diff] exact match in snippet view article find links to article

code name ORY-2001) is a dual inhibitor of the enzymes lysine-specific demethylase 1 (LSD1; KDM1A) and monoamine oxidase B (MAO-B) which is under development

RIOX1 (152 words) [view diff] exact match in snippet view article find links to article

metal ion binding histone H3-methyl-lysine-4 demethylase activity histone H3-methyl-lysine-36 demethylase activity 2-oxoglutarate-dependent dioxygenase

Oxidoreductase NAD-binding domain (222 words) [view diff] exact match in snippet view article find links to article

nitrate reductase from plants, nitric-oxide synthase, bacterial vanillate demethylase and others. Xanthine dehydrogenases, that also bind FAD/NAD, have essentially

N-Nitrosonornicotine (988 words) [view diff] exact match in snippet view article find links to article

of the stomach. Nicotine is converted into nornicotine via nicotine N-demethylase (NND), an enzyme found in the tobacco plant that works by removing the

UTY (74 words) [view diff] exact match in snippet view article find links to article

Japanese broadcast network affiliated with the JNN UTY (gene), histone demethylase UTY, enzyme that in humans is encoded by the UTY gene Undertale Yellow

Methyl-CpG-binding domain protein 2 (1,442 words) [view diff] exact match in snippet view article find links to article

Ramchandani S, Cervoni N, Szyf M (1999). "A mammalian protein with specific demethylase activity for mCpG DNA". Nature. 397 (6720): 579–83. Bibcode:1999Natur

PHF2 (205 words) [view diff] exact match in snippet view article find links to article

ontology Molecular function iron ion binding histone H3-methyl-lysine-9 demethylase activity transcription coactivator activity dioxygenase activity metal

Li Zhang (biologist) (946 words) [view diff] exact match in snippet view article

proteins; Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family; Heme: A versatile signaling

Pisatin (1,370 words) [view diff] exact match in snippet view article find links to article

shown to reduce the toxicity of the molecule. An enzyme known as pisatin demethylase is responsible for this catalysis and has been identified in N. haematococca

SHOX2 (696 words) [view diff] exact match in snippet view article find links to article

(2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor". BMB Rep. 42 (3):

Bomedemstat (1,083 words) [view diff] exact match in snippet view article find links to article

Bomedemstat was developed to inhibit the human enzyme lysine-specific demethylase-1 (LSD1 or KDM1A EC:1.14.99.66), an oxidating enzyme that mediates demethylation

Ethylmorphine (445 words) [view diff] exact match in snippet view article find links to article

PMID 9547411. Amacher DE, Schomaker SJ (January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic

PHF21A (554 words) [view diff] exact match in snippet view article find links to article

C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6): 857–64. doi:10

Chromosome 16 (1,670 words) [view diff] exact match in snippet view article find links to article

Jupiter microtubule associated homolog 2 KDM8: encoding protein Lysine demethylase 8 KIAA0895L: uncharacterized protein KIAA0895-like LINC00273 encoding

List of cytochrome P450 modulators (78 words) [view diff] exact match in snippet view article find links to article

(25-hydroxyvitamin D3 1α-hydroxylase) CYP39A1 (oxysterol 7α-hydroxylase 2) CYP46A1 (cholesterol 24-hydroxylase) CYP51A1 (lanosterol 14α-demethylase)

X-linked recessive inheritance (1,754 words) [view diff] exact match in snippet view article find links to article

disability and facial dysmorphism, caused by mutations in the histone demethylase PHF8 Simpson–Golabi–Behmel syndrome; coarse faces with protruding jaw

Patrik Rorsman (955 words) [view diff] exact match in snippet view article find links to article

Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10

SALL4 (4,631 words) [view diff] exact match in snippet view article find links to article

to bind to other epigenetic modifiers such as histone lysine-specific demethylase 1 (LSD1), which is frequently associated with the NuRD complex and subsequently

Chromosome 12 (1,843 words) [view diff] exact match in snippet view article find links to article

subfamily A member 1 at 12p13.32 KDM2B: encoding protein Lysine (K)-specific demethylase 2B KERA: keratocan KRAS: V-Ki-ras2 Kirsten rat sarcoma viral oncogene

Chromosome 11 (1,930 words) [view diff] exact match in snippet view article find links to article

encoding protein IGF2 antisense RNA INS: insulin gene KDM2A: lysine demethylase 2A KIAA1549L encoding protein KIAA1549-like KRTAP5-6: encoding protein

Cheb (disambiguation) (151 words) [view diff] exact match in snippet view article

Algerian raï musician Cheb (musician), Moroccan musician CheB, is a demethylase of methyl-accepting chemotaxis proteins (MCP) This disambiguation page

Temperature-dependent sex determination (3,823 words) [view diff] exact match in snippet view article find links to article

and American researchers showed that the histone H3 lysine 27 (H3K27) demethylase KDM6B (JMJD3), an epigenetic modifier, activates male development in

Tomas Lindahl (1,308 words) [view diff] exact match in snippet view article find links to article

Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10

MMACHC (1,096 words) [view diff] exact match in snippet view article find links to article

ontology Molecular function cobalamin binding protein binding FAD binding demethylase activity protein homodimerization activity glutathione binding cyanocobalamin

Ruegeria pomeroyi (1,097 words) [view diff] exact match in snippet view article find links to article

Whitman, William B. (2008-12-01). "Dimethylsulfoniopropionate-dependent demethylase (DmdA) from Pelagibacter ubique and Silicibacter pomeroyi". Journal of

4,4'-Dihydroxybenzophenone (203 words) [view diff] exact match in snippet view article find links to article

4′-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14α-demethylase (CYP51)". Journal of Biological Chemistry. 283 (22): 15152–15159. doi:10

Chromosome 7 (2,949 words) [view diff] exact match in snippet view article find links to article

IQCE: IQ domain-containing protein E KDM7A: encoding protein Lysine demethylase 7A LCHN: protein encoded by the KIAA1147 gene LHFPL3: LHFPL tetraspan

PELP-1 (3,909 words) [view diff] exact match in snippet view article find links to article

including CBP/p300, histone deacetylase 2, histones, SUMO2, lysine-specific demethylase 1 (KDM1), PRMT6, and CARM1. PELP1 also interacts with cell cycle regulators

Pseudomonas putida (1,572 words) [view diff] exact match in snippet view article find links to article

M (2011). "Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids

Pseudomonas putida (1,572 words) [view diff] exact match in snippet view article find links to article

M (2011). "Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids

Tranylcypromine (2,535 words) [view diff] exact match in snippet view article find links to article

release. Tranylcypromine has also been shown to inhibit the histone demethylase, BHC110/LSD1. Tranylcypromine inhibits this enzyme with an IC50 < 2 μM

H3K4me1 (1,611 words) [view diff] exact match in snippet view article find links to article

cell specific gene regulation. Suppression of the H3K4 mono- and di-demethylase LSD-1 might extend lifespan in various species. H3K4me allows binding

Withaferin A (764 words) [view diff] exact match in snippet view article find links to article

cycloartenol synthase (CAS), sterol methyl transferase (SMT), obtusifoliol-14 –demethylase (ODM). To produce withaferin A from 24-methylene cholesterol, the molecule

Cleft lip and cleft palate (10,270 words) [view diff] exact match in snippet view article find links to article

gene PHF8. The research found that PHF8 encodes for a histone lysine demethylase, and is involved in epigenetic regulation. The catalytic activity of

29-Norlanosterol (116 words) [view diff] exact match in snippet view article find links to article

obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and

Norcycloartenol (302 words) [view diff] exact match in snippet view article find links to article

requirements for substrate recognition of Mycobacterium tuberculosis 14 alpha-demethylase: implications for sterol biosynthesis". Journal of Lipid Research. 42

ARID5B (641 words) [view diff] exact match in snippet view article find links to article

transcription repressor activity, RNA polymerase II-specific histone demethylase activity DNA-binding transcription factor activity, RNA polymerase II-specific

Mary Beckerle (1,672 words) [view diff] exact match in snippet view article find links to article

is focused on an essential regulating protein called lysine specific demethylase (LSD1). Preliminary research has aimed to halt the function of LSD1 to

CNOT4 (572 words) [view diff] exact match in snippet view article find links to article

Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development

Hypothenemus hampei (1,465 words) [view diff] exact match in snippet view article find links to article

consists of ca. 163 million base pairs (Vega et al. 2015 [3]. Caffeine demethylase has been shown to be responsible for caffeine breakdown in the alimentary

PCGF6 (618 words) [view diff] exact match in snippet view article find links to article

Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein". Cell. 128 (5): 877–87. doi:10

Stephen O'Rahilly (1,623 words) [view diff] exact match in snippet view article find links to article

Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10

Biomarkers of aging (2,575 words) [view diff] exact match in snippet view article find links to article

experienced by the organism as it develops and ages. UTX-1, a H3K27me3 demethylase, plays a critical role in the aging of C.elegans: increased utx-1 expression

Yang Shi (101 words) [view diff] exact match in snippet view article find links to article

Yang Shi Known for found Lysine-specific demethylase 1 Scientific career Fields Epigenetics Institutions Harvard University University of Oxford

Philip Kantoff (968 words) [view diff] exact match in snippet view article find links to article

inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D". The Journal of Clinical Investigation. 128 (7): 2979–2995. doi:10

Viridin (728 words) [view diff] exact match in snippet view article find links to article

the C-14 methyl group is lost as formic acid by action of sterol 14-demethylase. Though the C-13 methyl group isn't removed in the pathway of aldosterone

KMT2D (3,946 words) [view diff] exact match in snippet view article find links to article

domain-containing fragments of human KMT2C and KMT2D. UTX, the complex's H3K27 demethylase, PTIP, and PA1 are subunits that are unique to KMT2C and KMT2D. KMT2D

Unspecific monooxygenase (978 words) [view diff] exact match in snippet view article find links to article

K, Takahashi K, Katagiri M (1988). "Aromatase and nonaromatizing 10-demethylase activity of adrenal cortex mitochondrial P-450(11)beta". Arch. Biochem

Cellular differentiation (6,030 words) [view diff] exact match in snippet view article find links to article

(ESC) genes, and the activation of cell fate genes. Lysine specific demethylase 1 (KDM1A) is thought to prevent the use of enhancer regions of pluripotency

Dicamba (3,143 words) [view diff] exact match in snippet view article find links to article

first breakdown step comprise a three-component system called dicamba O-demethylase. In the 2000s, Monsanto incorporated one component of the three enzymes

CACUL1 (483 words) [view diff] exact match in snippet view article find links to article

regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1". FEBS Lett. 587 (1): 17–22. doi:10.1016/j.febslet.2012.10.054.

Set domain containing 1b (375 words) [view diff] exact match in snippet view article find links to article

atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual

H3K4me3 (2,323 words) [view diff] exact match in snippet view article find links to article

Clouaire T, Aguirrebengoa M, Legube G, Miller KM (July 2017). "Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair"

Sadaf Farooqi (1,303 words) [view diff] exact match in snippet view article find links to article

Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10

FBXL4 (627 words) [view diff] exact match in snippet view article find links to article

leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein". The Journal

FHL2 (5,044 words) [view diff] exact match in snippet view article find links to article

(Dec 2006). "Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer

Gerry Wright (450 words) [view diff] exact match in snippet view article find links to article

Biochemistry Institutions McMaster University Thesis Investigation of the lanosterol 14[alpha]-demethylase (P-45014DM) from Saccharomyces cerevisiae (1990)

Mothers against decapentaplegic homolog 3 (4,115 words) [view diff] exact match in snippet view article find links to article

Janknecht R (February 2008). "Repression of Smad3 activity by histone demethylase SMCX/JARID1C". Biochemical and Biophysical Research Communications. 366

Alfred G. Gilman (3,668 words) [view diff] exact match in snippet view article find links to article

ISBN 978-1-4381080-70. Gilman, AG; Conney, AH (1963). "The induction of aminoazo dye N-demethylase in nonhepatic tissues by 3-methylcholanthrene". Biochemical Pharmacology

Hypoxia-inducible factor (4,943 words) [view diff] exact match in snippet view article find links to article

Ringel AE, Booker MA, Tolstorukov MY, et al. (March 2019). "Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate". Science

Y chromosome (8,152 words) [view diff] exact match in snippet view article find links to article

USP9Y USP9X Ubiquitin protease. DDX3Y DDX3X Helicase. UTY UTX Histone demethylase. TB4Y TB4X AZFb (none) Second AZF region on arm q. Prone to NAHR [non-allelic

Xp11.2 duplication (3,270 words) [view diff] exact match in snippet view article find links to article

or refuting this possibility remains absent. KDM5C (Lysine-Specific Demethylase 5C) also known as jumonji, A/T-rich interactive domain 1C (JARID1C) is

Chris Ponting (1,832 words) [view diff] exact match in snippet view article find links to article

Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10

Chuan He (1,145 words) [view diff] exact match in snippet view article find links to article

regulatory roles. He and colleagues subsequently discovered the first RNA demethylase that oxidatively reverses N6-methyladenosine (m6A) methylation in mammalian

Repressilator (2,190 words) [view diff] exact match in snippet view article find links to article

Evening-phased transcription factor CCA1 Hiking Expedition (CHE) and histone demethylase jumonji C domain-containing 5 (JMJD5) directly repress CCA1. Other components

Jian-Kang Zhu (2,374 words) [view diff] exact match in snippet view article find links to article

5-methylcytosine DNA glycosylase/lyase ROS1 in 2002. ROS1 is the first DNA demethylase (the enzyme initiating active DNA demethylation) established with genetic

Azoospermia factor (1,143 words) [view diff] exact match in snippet view article find links to article

Eukaryotic Translation Initiation Factor 1A, Y-linked (EIF1AY), Lysine Demethylase 5D (KDM5D), X Linked Kell Blood Group Precursor, Y-linked (XKRY), and

TMEM242 (1,522 words) [view diff] exact match in snippet view article find links to article

notable transcription factor is the Retinoblastoma-binding protein with demethylase activity. There are ubiquitous basal level expression of tmem242 in all

Acute myeloid leukemia (7,543 words) [view diff] exact match in snippet view article find links to article

likely in the early stages of AML. Such mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation

Vestigial-like family member 3 (566 words) [view diff] exact match in snippet view article find links to article

2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor" (PDF). BMB Reports

DNA oxidation (4,790 words) [view diff] exact match in snippet view article find links to article

promoter regions. Perillo et al., showed that the lysine-specific histone demethylase LSD1 generates a local burst of reactive oxygen species (ROS) that induces

List of EC numbers (EC 2) (21,664 words) [view diff] exact match in snippet view article

(cytosine32-N3)-methyltransferase EC 2.1.1.269: dimethylsulfoniopropionate demethylase EC 2.1.1.270: (+)-6a-hydroxymaackiain 3-O-methyltransferase EC 2.1.1

Marjorie Bick (2,424 words) [view diff] exact match in snippet view article find links to article

L (1972). "The inductive effect of piperonyl butoxide on microsomal demethylase activity". Science of the Total Environment. 1 (2): 197–203. Bibcode:1972ScTEn

Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase (615 words) [view diff] exact match in snippet view article find links to article

activity 2-oxoglutarate-dependent dioxygenase activity cytosine C-5 DNA demethylase activity Cellular component nucleus mitochondrion nucleoplasm cytoplasm

Akane Kawamura (467 words) [view diff] exact match in snippet view article find links to article

2011). "The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases". EMBO Reports. 12 (5): 463–9. doi:10.1038/EMBOR.2011.43. ISSN 1469-221X

List of MeSH codes (D08) (15,232 words) [view diff] exact match in snippet view article

oxidoreductases, n-demethylating MeSH D08.811.682.662.582.276 – aminopyrine n-demethylase MeSH D08.811.682.662.582.338 – cytochrome p-450 cyp2e1 MeSH D08.811.682

C7orf25 (683 words) [view diff] exact match in snippet view article find links to article

of transcription 409 427 - RBP2 Retinoblastoma-binding proteins with demethylase activity 538 546 - YY1F Activator/repressor binding to transcription

Sónia Rocha (1,435 words) [view diff] exact match in snippet view article find links to article

MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG (2019). "Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate". Science

Zebrafish (12,241 words) [view diff] exact match in snippet view article find links to article

Stewart S, Tsun ZY, Izpisua Belmonte JC (November 2009). "A histone demethylase is necessary for regeneration in zebrafish". Proceedings of the National

AOC3 (3,002 words) [view diff] exact match in snippet view article find links to article

copper dependent class of amine oxidases, such as lysyl oxidase or lysine demethylase, and is one of the four known in humans. The other class is flavin dependent

FGFR1OP2 (1,126 words) [view diff] exact match in snippet view article find links to article

endothelial growth 0.923 + acaCACGcact RBP2 Retinoblastoma-binding protein 2 Demethylase 1.000 + GCACagcgc PLAG1 Pleomorphic adenoma gene 1 Cell proliferation

List of EC numbers (EC 3) (15,555 words) [view diff] exact match in snippet view article

hydrolase * EC 3.3.2.13: chorismatase * EC 3.3.2.14: 2,4-dinitroanisole O-demethylase * EC 3.3.2.15: trans-2,3-dihydro-3-hydroxyanthranilic acid synthase *

Cancer epigenetics (12,533 words) [view diff] exact match in snippet view article find links to article

their corresponding enzymes. Several histone methyltransferases and demethylases are among these enzymes. Prostate cancer kills around 35,000 men yearly

Epigenetics in forensic science (1,688 words) [view diff] exact match in snippet view article find links to article

and quite a few affect the epigenome. For example, JMJD3 is a histone demethylase that modifies the methylation of homeobox and bone morphogenetic proteins

H3K9me2 (2,617 words) [view diff] exact match in snippet view article find links to article

and PRDM2. H3K9me2 can be removed by a wide range of histone lysine demethylases (KDMs) including KDM1, KDM3, KDM4 and KDM7 family members. H3K9me2 is

Penicillium digitatum (3,387 words) [view diff] exact match in snippet view article find links to article

imazalil is suggested to lie in the over-expression of the sterol 14α-demethylase (CYP51) protein caused by a 199 base-pair insertion into the promoter

TEDC2 (1,503 words) [view diff] exact match in snippet view article find links to article

or threonine that could be phosphorylated. KDM1A, a lysine-specific demethylase, was shown to be physically associated with TEDC2. TEDC2 also interacts

Coiled-coil domain containing 74a (1,231 words) [view diff] exact match in snippet view article find links to article

post-translational methylation, CCDC74A has been shown to interact with the lysine demethylase KDM1A through a yeast 2-hybrid assay. Additionally, through a yeast 2-hybrid

Neuroepigenetics (3,861 words) [view diff] exact match in snippet view article find links to article

An eraser, neuroLSD1, is a modified version of the original Lysine Demethylase 1(LSD1) that exists only in neurons and assists with neuronal maturation

Coiled-coil domain-containing 37 (FLJ40083) (820 words) [view diff] exact match in snippet view article

histone-lysine N-methyltransferase (SUV39H2), and lysine-specific histone demethylase 1A (KDM1A). In a study of the genes expressed in lung squamous cell carcinomas

Epitranscriptome (7,732 words) [view diff] exact match in snippet view article find links to article

demethylase found in mammals that removes the methyl group of m6A. The second one is the fat mass and obesity associated protein (FTO), a demethylase

Epigenome editing (3,420 words) [view diff] exact match in snippet view article find links to article

translocation methylcytosine dioxygenase 1 (TET1), Lysine (K)-specific demethylase 1A (LSD1) and Calcium and integrin binding protein 1 (CIB1). The use

Long non-coding RNA (13,137 words) [view diff] exact match in snippet view article find links to article

factors by coordinating intrachromosomal looping and recruitment of DNA demethylase TET2. In Drosophila, long ncRNAs induce the expression of the homeotic

TMEM271 (922 words) [view diff] exact match in snippet view article find links to article

increased expression in a tissue with resistance to SP, a lysine-specific demethylase-1 inhibitor drug used to treat Ewing’s Sarcoma. GRCh38: Ensembl release

2,2',3,3',4,4'-Hexachlorobiphenyl (1,866 words) [view diff] exact match in snippet view article find links to article

found increased activation of ethoxyresorufin deethylase and aminopyrine demethylase. However, while also observing an increased liver wight, it did not find

C1orf68 (1,750 words) [view diff] exact match in snippet view article find links to article

Guoqing (2014). "Human Chromatin Related Protein Interactions Identify a Demethylase Complex Required for Chromosome Segregation". Cell Reports. 8 (1): 297–310

Ilya B. Tsyrlov (1,343 words) [view diff] exact match in snippet view article find links to article

PMID 475855. Tsyrlov, I. B.; Gerasimov, K. E. (1991). "Aminopyrine-N-demethylase. I. Directed modification of substrates' structure as a way of production

Bioenhancer (2,375 words) [view diff] exact match in snippet view article find links to article

different enzymes: aryl hydrocarbon hydroxylase (AHH), ethylmorphine N-demethylase, Uridine diphosphate glucuronic_acid, Uridine diphosphate glucuronyltransferase

Stress granule (12,460 words) [view diff] exact match in snippet view article find links to article

Reineke LC, Jain A, Jung SY, Lloyd RE (November 2017). "Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the

Epigenetics of schizophrenia (5,482 words) [view diff] exact match in snippet view article find links to article

transcripts in patients experiencing psychotic symptoms. HMT (histone demethylase) inhibitors also act on histones. They prevent the demethylation of the

Epigenetic therapy (5,831 words) [view diff] exact match in snippet view article find links to article

and MMP-9 genes, an increase in transcription of LSD1, a H3K4 and H3K9 demethylase, and various DNA Methyl-Transferases (DNMTs), and increased presence

NBPF26 (718 words) [view diff] exact match in snippet view article find links to article

nuclease (multifunctional DNA repair enzyme) 1 (APEX1), lysine (K)-specific demethylase 1A (KDM1A), trans-golgi network protein 2 (TGOLN2), and tripartite motif

Topical antifungal (3,320 words) [view diff] exact match in snippet view article find links to article

target the ergosterol biosynthetic pathway by inhibiting the C-14 α-demethylase, a cytochrome P450 enzyme, thus preventing the demethylation of lanosterol

Induced cell cycle arrest (3,275 words) [view diff] exact match in snippet view article find links to article

Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway". Genetics. 204 (3): 959–973.

RNA-directed DNA methylation (14,822 words) [view diff] exact match in snippet view article find links to article

methylation and demethylation activity. Interestingly, expression of the DNA demethylase ROS1 is directly tied to RdDM activity: DNA methylation over a TE targeted

Jacob Hanna (5,661 words) [view diff] exact match in snippet view article find links to article

regulators influencing iPSC derivation efficiency such as the role of H3K27 demethylase Utx in iPS formation, and first demonstrated the deterministic reprogramming

List of investigational autism and pervasive developmental disorder drugs (3,022 words) [view diff] exact match in snippet view article find links to article

3β (GSK-3β) inhibitor Vafidemstat (ORY-2001) – dual lysine specific demethylase 1 (LSD1) inhibitor and monoamine oxidase B (MAO-B) inhibitor Xenon (NBTX-001)

X-chromosome reactivation (5,094 words) [view diff] exact match in snippet view article find links to article

M, Ghariani SC, et al. (January 2012). "Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome". American