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searching for FOXP3 70 found (144 total)

alternate case: fOXP3

Neurovax (139 words) [view diff] exact match in snippet view article find links to article

currently in phase II clinical trials. Neurovax is designed to stimulate FOXP3+ regulatory T-cells that can then suppress the autoreactive T-cells in some

Scutellarin (542 words) [view diff] case mismatch in snippet view article find links to article

antitumor action is to bind to TNF receptor II (TNFR2) in tumor-associated CD4+Foxp3+ regulatory T cells. These tumor "helper" cells show high expression of

Hassall's corpuscles (583 words) [view diff] case mismatch in snippet view article find links to article

increases the ability of dendritic cells to convert naive thymocytes to a Foxp3+ regulatory T cell lineage. It is unknown if this is the physiological function

Death receptor 3 (1,592 words) [view diff] case mismatch in snippet view article find links to article

antigen-experienced T lymphocytes. TNFRSF25 is also highly expressed by FoxP3 positive regulatory T lymphocytes. TNFRSF25 is activated by a monogamous

Alfred Singer (929 words) [view diff] case mismatch in snippet view article find links to article

Wiessman JD, Singer A, Singer DS: Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function. Journal of Immunology. 192:

GPR83 (328 words) [view diff] case mismatch in snippet view article find links to article

83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo". J. Immunol. 177 (1): 209–15. doi:10.4049/jimmunol

Shyam Sundar (465 words) [view diff] case mismatch in snippet view article find links to article

Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis Trial of oral miltefosine

Thymic epithelial cell (1,407 words) [view diff] case mismatch in snippet view article find links to article

implementation of self tolerance, which is mediated by CD4+CD25+Foxp3 nTreg cells. Foxp3 Treg development is supported by mTECs during negative selection

Decitabine (716 words) [view diff] exact match in snippet view article find links to article

Park JB, et al. (June 2009). "Use of epigenetic modification to induce FOXP3 expression in naïve T cells". Transplantation Proceedings. 41 (5): 1848–1854

Peripheral tolerance (2,978 words) [view diff] case mismatch in snippet view article find links to article

peripheral tolerance. The master regulator of Treg phenotype and function is Foxp3. Natural Tregs (nTregs) are generated in the thymus during the negative

Harald von Boehmer (1,435 words) [view diff] case mismatch in snippet view article find links to article

MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., Young, R. A.: Foxp3 occupancy and regulation of key target genes during T-cell stimulation.

Theralizumab (4,316 words) [view diff] exact match in snippet view article find links to article

FOXP3. However, eventually most of these cells downregulate their regulatory capabilities and become effector cells. Thus, attempts to induce FOXP3+

Mohan R. Wani (849 words) [view diff] case mismatch in snippet view article find links to article

Attenuates Collagen-Induced Arthritis by Modulating the Development of Foxp3+ Regulatory T Cells". The Journal of Immunology. 186 (4): 2262–2272. doi:10

MiR-155 (10,217 words) [view diff] case mismatch in snippet view article find links to article

Scudamore C, Turner M, Okkenhaug K, Vigorito E (Mar 2009). "Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells". Journal

Brigitta Stockinger (740 words) [view diff] case mismatch in snippet view article find links to article

; O'Garra, A (2004). "IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+

Trichostatin A (690 words) [view diff] exact match in snippet view article find links to article

Park JB, et al. (June 2009). "Use of epigenetic modification to induce FOXP3 expression in naïve T cells". Transplantation Proceedings. 41 (5): 1848–1854

Lung microbiota (1,683 words) [view diff] exact match in snippet view article find links to article

response and anti-inflammatory interleukin (IL)-10, antimicrobial peptides, FOXP3, secretory immunoglobulin A (sIgA) production. Changes in microbial community

Dedicator of cytokinesis protein 11 (970 words) [view diff] exact match in snippet view article find links to article

Abnormal regulatory T cells (Tregs) phenotype with profoundly reduced FOXP3 and IKZF2 expression was also observed, consistent with the autoimmune features

Interleukin 29 (1,663 words) [view diff] exact match in snippet view article find links to article

"Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells". Blood. 107 (11): 4417–23. doi:10.1182/blood-2005-10-4129

Interferon Lambda 3 (1,488 words) [view diff] exact match in snippet view article find links to article

"Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells". Blood. 107 (11): 4417–23. doi:10.1182/blood-2005-10-4129

Interleukin 7 (1,675 words) [view diff] case mismatch in snippet view article find links to article

CD4+ T cells with a commensurate decrease in the percentage of CD4+CD25+Foxp3+ T regulatory cells. No objective cancer regression was observed, however

Hashimoto's thyroiditis (7,888 words) [view diff] case mismatch in snippet view article find links to article

secretion of TGF-β (inhibitor of cytokine production), and mutations of FoxP3, an essential regulatory factor for the Tregs development. Development of

Interleukin-7 receptor-α (840 words) [view diff] exact match in snippet view article find links to article

"Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it

Immunosuppressive drug (3,378 words) [view diff] exact match in snippet view article find links to article

mofetil-based immunosuppression changes the frequency and phenotype of CD4+FOXP3+ regulatory T cells". Transplantation. 87 (7): 1062–1068. doi:10.1097/tp

Sertoli cell (3,061 words) [view diff] case mismatch in snippet view article find links to article

decreasing proliferation of effector T-cells Jagged1 (JAG1) – induction of Foxp3 transcription factor expression in naive T lymphocytes (increasing relative

Leukocyte apheresis (292 words) [view diff] case mismatch in snippet view article find links to article

PMC 1727082. PMID 9616306. Muratov V.; et al. (2008). "Decreased numbers of FoxP3-positive and TLR-2-positive cells in intestinal mucosa are associated with

Acrolein (2,126 words) [view diff] case mismatch in snippet view article find links to article

prevents allergy, but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure". Scientific Reports

MARCH7 (528 words) [view diff] exact match in snippet view article find links to article

Y, et al. (2007). "Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation

Javier Arias Stella (929 words) [view diff] exact match in snippet view article find links to article

suppressive B7H4(+) macrophages and the subpopulation of CD25(+) CD4(+) and FOXP3(+) regulatory T-cells in decidua during the secretory cycle phase, Arias

Urbanization (10,592 words) [view diff] case mismatch in snippet view article find links to article

of developing asthma. Studies have shown a positive correlation between Foxp3 methylation and children's exposure to NO2, CO, and PM2.5. Furthermore,

Adult T-cell leukemia/lymphoma (1,966 words) [view diff] exact match in snippet view article find links to article

markers. Additionally, there is partial positivity for CD30, CCR4, and FOXP3. Treatment options that have been tried include zidovudine and the CHOP

Co-receptor (3,129 words) [view diff] case mismatch in snippet view article find links to article

effect then spreads to native T cells which then switch to a CD4+CD25+GITR+FoxP3+ T regulatory phenotype. Currently, the two most prominent areas of co-receptor

TNFRSF18 (2,117 words) [view diff] case mismatch in snippet view article find links to article

plays role in Treg development, as it is expressed already at CD4+CD25+Foxp3- Treg progenitors. GITR-/- mice has no developmental problem and are fertile

CD86 (3,221 words) [view diff] case mismatch in snippet view article find links to article

PMID 31130955. Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S (July 2008). "Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic

Microchimerism (5,117 words) [view diff] exact match in snippet view article find links to article

interface. Mother's fetal-specific CD4+ T cells proliferate, and due to FOXP3 expression, differentiate into Treg cells. Mice models show that fetal-specific

NFKBID (841 words) [view diff] case mismatch in snippet view article find links to article

"IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor". Immunity. 37 (6): 998–1008. doi:10.1016/j.immuni

Immune privilege (3,160 words) [view diff] case mismatch in snippet view article find links to article

(IL-10) have all been implicated in the induction of immune tolerance. Foxp3 and neuropillin are markers expressed by the regulatory T-cells by which

Regulatory macrophages (1,836 words) [view diff] case mismatch in snippet view article find links to article

Evans HG, van Herwijnen MJ, John S, Taams LS (December 2007). "CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages"

Autoimmunity (5,851 words) [view diff] case mismatch in snippet view article find links to article

Regulatory T cell theory, wherein regulatory T-lymphocytes (commonly CD4+FoxP3+ cells, among others) function to prevent, downregulate, or limit autoaggressive

Juven (1,209 words) [view diff] exact match in snippet view article find links to article

Schulze JJ, Olek S, Kühn T (September 2016). "The Ratio of Regulatory (FOXP3+) to Total (CD3+) T Cells Determined by Epigenetic Cell Counting and Cardiovascular

Prostaglandin DP1 receptor (3,077 words) [view diff] case mismatch in snippet view article find links to article

cells to suppress airway allergic inflammation by increasing the number of Foxp3+ CD4+ regulatory T cells. Furthermore, DP1 activation reduces eosinophilia

Bernd Schröppel (1,037 words) [view diff] case mismatch in snippet view article find links to article

signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function, Am J Transplantation, 11(2):203-214, 2011

Lymphocyte-activation gene 3 (6,133 words) [view diff] case mismatch in snippet view article find links to article

et al. (Jun 2010). "LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites". Journal of Immunology

Siddhartha Mukherjee (5,474 words) [view diff] case mismatch in snippet view article find links to article

decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer". OncoImmunology. 6 (3): e1290034

FCRL3 (1,917 words) [view diff] exact match in snippet view article find links to article

natural killer cells, CD4+ and CD8+ T cells, as well as regulatory CD4+FOXP3+ T cells. Notably, it has also been observed on a subpopulation of natural

T cell receptor revision (1,333 words) [view diff] case mismatch in snippet view article find links to article

Pamela J. (Nov 1, 2007). "Cutting edge: TCR revision affects predominantly Foxp3 cells and skews them toward the Th17 lineage". Journal of Immunology. 179

John J. O'Shea (1,292 words) [view diff] case mismatch in snippet view article find links to article

Davidson, T. S.; Ramsey, H.; O'Shea, J. J.; Shevach, E. M. (2008). "CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF- -dependent manner"

Ana Anderson (504 words) [view diff] case mismatch in snippet view article find links to article

Anderson looks to understand the function of Treg in tumor tissue. CD4+FoxP3+ Treg are immunosuppressive cells that suppress anti-tumor immunity. Inside

Mario Rosemblatt (1,396 words) [view diff] case mismatch in snippet view article find links to article

Fierro. Dendritic Cells and B Cells Cooperate in the Generation of CD4+CD25+Foxp3+ Allogeneic T Cells. Transplant. Proc. 42; 371-5, 2010 Elgueta R., Sepulveda

Short course immune induction therapy (2,444 words) [view diff] case mismatch in snippet view article find links to article

induction and transient depletion of T cells, but an increase in CD4+ and CD8+ Foxp3+Tregs. While promising, islet function gradually decreased over time in

Sidonia Făgărășan (490 words) [view diff] case mismatch in snippet view article find links to article

Award Michelle Linterman; Wim Pierson; Sau K Lee; et al. (24 July 2011). "Foxp3+ follicular regulatory T cells control the germinal center response". Nature

Microbial symbiosis and immunity (4,527 words) [view diff] exact match in snippet view article find links to article

and can also neutralize PAMPs. IgA promotes the development of TH17 and FOXP3+ regulatory T cells. Given its critical function in the GI tract, the number

Michal Schwartz (2,123 words) [view diff] case mismatch in snippet view article find links to article

of immunoregulatory cells, including bone marrow-derived macrophages and FoxP3 regulatory T cells, though the balance between regulatory T cells and effector

Sankar Ghosh (2,448 words) [view diff] case mismatch in snippet view article find links to article

modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 18: 921–931. Park, S.-G., Schulze-Luehrman

Martin Turner (scientist) (1,885 words) [view diff] case mismatch in snippet view article

C., Turner, M., Okkenhaug, K., Vigorito, E. (2009). Cutting edge: The Foxp3 target miR-155 contributes to the development of regulatory T cells. J.

CD4+ T cells and antitumor immunity (4,000 words) [view diff] case mismatch in snippet view article find links to article

and immune homeostasis. Treg differentiation is induced by expression of FoxP3 transcription factor, and Tregs secrete a variety of immunosuppressive cytokines

Metronomic therapy (2,949 words) [view diff] exact match in snippet view article find links to article

means to evade immunosurveillance of the host. The number of CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) was found to increase in various types of tumors

Medullary thymic epithelial cells (3,544 words) [view diff] case mismatch in snippet view article find links to article

Hinterberger M, Emmerich J, Swee LK, Rolink A, Klein L (April 2007). "Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by

Tissue cytometry (3,073 words) [view diff] case mismatch in snippet view article find links to article

the impact of various immune cell subpopulations (CD4, CD68, CD8, CD20, Foxp3, PD1) on patient survival in different cancer types (e.g. breast cancer

Immunometabolism (3,181 words) [view diff] case mismatch in snippet view article find links to article

glycolysis leads to enolase (a glycolytic enzyme) binding to a splice variant of Foxp3, which effectively compromises peripheral Tregs abilities to act as immunosuppressive

Francisco J. Quintana (2,559 words) [view diff] case mismatch in snippet view article find links to article

Quintana F.J. Aryl hydrocarbon receptor activation induces human Tr1-like and Foxp3+ Treg cells. Nature Immunology, 11(9), 846-53 (2010). 6. Yeste, A., Nadeau

Cancer-associated fibroblast (3,599 words) [view diff] case mismatch in snippet view article find links to article

restriction of anti-tumor immunity are crucial regulatory T cells (Treg; Foxp3+). CAFs stimulate migration, induction and maintenance of Treg cells which

C20orf27 (3,092 words) [view diff] exact match in snippet view article find links to article

Y, Li R, Guo TB, He D, Fang L, et al. (March 2013). "Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid

List of autoimmune diseases (6,053 words) [view diff] exact match in snippet view article find links to article

disorder but not an autoimmune disease. IPEX syndrome A genetic mutation in FOXP3 that leads to autoimmune diseases, but not an autoimmune disorder itself

Peptidoglycan recognition protein 1 (6,550 words) [view diff] case mismatch in snippet view article find links to article

Curiel T, Odunsi K, et al. (March 2017). "Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells"

Epigenetics of autoimmune disorders (7,834 words) [view diff] exact match in snippet view article find links to article

to the development of Sjogren's syndrome. Decreased expression of the FOXP3 gene, which leads to DNA hypermethylation, is also observed in these CD4+

Murine respirovirus (31,942 words) [view diff] exact match in snippet view article find links to article

"Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans". Proceedings of the National Academy

Epigenetics of neurodegenerative diseases (13,392 words) [view diff] case mismatch in snippet view article find links to article

thymoma-associated myasthenia gravis. MiRNA-12a-5p inhibits expression of the gene FoxP3, a gene known to be associated with normal thymus development and whose

Zihai Li (3,625 words) [view diff] case mismatch in snippet view article find links to article

Xuyu; Li, Zihai; Li, Xin; Meng, Songdong (December 2021). "Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases"

List of human transcription factors (81 words) [view diff] exact match in snippet view article find links to article

ENSG00000128573 Forkhead Known motif – High-throughput in vitro [281] RTAAAYAW FOXP3 ENSG00000049768 Forkhead Known motif – High-throughput in vitro [282] RTAAACA