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searching for Peripheral tolerance 14 found (38 total)

EMR1 (781 words) [view diff] exact match in snippet view article find links to article

for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance. EMR1 can serve as a therapeutic target for depletion of these cells

Type 1 regulatory T cell (1,883 words) [view diff] exact match in snippet view article find links to article

non-self antigen specific and their key role is to induce and maintain peripheral tolerance and suppress tissue inflammation in autoimmunity and graft vs. host

Bcl-2 (4,568 words) [view diff] exact match in snippet view article find links to article

cause immune unresponsiveness to self-antigens via both central and peripheral tolerance. In the case of defective apoptosis, it may contribute to etiological

Ralph M. Steinman (1,701 words) [view diff] exact match in snippet view article find links to article

peripheral organs and induce different forms of antigen-specific peripheral tolerance. Antigens from the periphery are captured by DCs in lymphoid tissues

MHC class I (2,917 words) [view diff] exact match in snippet view article find links to article

CTLs will not be activated in response to them due to central and peripheral tolerance mechanisms. When a cell expresses foreign proteins, such as after

NKG2D (3,695 words) [view diff] exact match in snippet view article find links to article

to apoptosis of NK cells. NKG2D is involved in the generation of peripheral tolerance by the effective downregulation of NKG2D ligands, for the prevention

Tolerogenic dendritic cell (2,765 words) [view diff] exact match in snippet view article find links to article

response. Tolerogenic DCs are essential in maintenance of central and peripheral tolerance through induction of T cell clonal deletion, T cell anergy and generation

Harald von Boehmer (1,435 words) [view diff] exact match in snippet view article find links to article

Peripheral selection of the T cell repertoire. Science 251, 1225 (1991). Peripheral tolerance by deletion of and reversible anergy in matureT cells. Borgulya,

Betty Diamond (1,437 words) [view diff] exact match in snippet view article find links to article

Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells, and the defects in these mechanisms that

Programmed cell death protein 1 (4,995 words) [view diff] exact match in snippet view article find links to article

(January 2011). "The role of the PD-1 pathway in autoimmunity and peripheral tolerance". Annals of the New York Academy of Sciences. 1217 (1): 45–59.

HAVCR1 (1,871 words) [view diff] exact match in snippet view article find links to article

"TIM-1 induces T cell activation and inhibits the development of peripheral tolerance". Nature Immunology. 6 (5): 447–454. doi:10.1038/ni1186. PMID 15793575

Autoimmune enteropathy (5,485 words) [view diff] exact match in snippet view article find links to article

the growth and activation of self-reactive T cells and promotes peripheral tolerance. LRBA deficiency is inherited autosomal recessively and manifests

Linda Sherman (882 words) [view diff] exact match in snippet view article find links to article

remarried. Reviews William L. Redmond, Linda A. Sherman (2005). Peripheral tolerance of CD8 T lymphocytes. Immunity 22 (3): 275–84 doi:10.1016/j.immuni

Dario Angelo Alberto Vignali (3,517 words) [view diff] exact match in snippet view article find links to article

with Treg loss. Importantly, this pathway appears dispensable for peripheral tolerance maintenance. Further, the cytokine interferon-gamma (IFN) was shown