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searching for MSH2 34 found (81 total)

alternate case: mSH2

Sebaceous carcinoma (3,253 words) [view diff] exact match in snippet view article find links to article

adenocarcinoma. MTS results from defects in DNA mismatch repair genes, MLH1, MSH2, and MSH6, leading to a buildup of unstable microsatellite sequences and

List of genes mutated in cutaneous conditions (108 words) [view diff] exact match in snippet view article find links to article

Muir–Torre syndrome MLPH Griscelli syndrome MITF Waardenburg syndrome type 2 MSH2 Muir–Torre syndrome MSX1 Witkop syndrome MYO5A Griscelli syndrome NF1 Neurofibromin

Keratin 20 (1,176 words) [view diff] exact match in snippet view article find links to article

González JJ, Bernardo CG, Sanz L, et al. (2007). "Mismatch repair protein MSH2, cytokeratin 18 and cytokeratin 20 expression: clinicopathological correlation

Chromosome segregation (1,706 words) [view diff] case mismatch in snippet view article find links to article

(2014). "Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc

Proliferating cell nuclear antigen (6,158 words) [view diff] exact match in snippet view article find links to article

"Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes". J. Biol. Chem. 275 (47): 36498–501. doi:10.1074/jbc

Dana–Farber Cancer Institute (1,783 words) [view diff] exact match in snippet view article find links to article

the gene that increases the risk for a common type of colon cancer. The MSH2 gene and later the MLH1 gene (also by DFCI investigators) are linked to hereditary

Carcinoma (3,232 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079

Shapiro–Senapathy algorithm (6,804 words) [view diff] exact match in snippet view article find links to article

Nicoline; Nagtegaal, Iris D. (March 2014). "Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like

Temozolomide (2,958 words) [view diff] exact match in snippet view article find links to article

tumors with temozolomide and then selection or induction of mutant MSH6, MSH2, MLH1, or PMS2 proteins and cells which are MMRd and temozolomide resistant

M. R. S. Rao (1,249 words) [view diff] exact match in snippet view article find links to article

Michael; Kolodner, Richard (3 December 1993). "The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer, Cell, 1993;

MLH3 (1,528 words) [view diff] case mismatch in snippet view article find links to article

(2014). "Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc

Cell damage (2,829 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079

SMUG1 (2,216 words) [view diff] case mismatch in snippet view article find links to article

uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice". Nucleic Acids Research. 40 (13): 6016–25. doi:10.1093/nar/gks259

Richard Kolodner (632 words) [view diff] exact match in snippet view article find links to article

in bacteria and yeast, Kolodner identified two DNA mismatch repair genes, MSH2 and MLH1, that lead to 95 percent of hereditary colon cancer cases. In both

Field cancerization (1,850 words) [view diff] exact match in snippet view article find links to article

Juhng SW, Lee JH (October 2011). "Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence"

Transgenerational epigenetic inheritance (10,351 words) [view diff] exact match in snippet view article find links to article

positively with familial history of cancer. Furthermore, methylation of the MSH2 gene is correlated with early-onset colorectal and endometrial cancers. Experimentally

Physcomitrella patens (2,426 words) [view diff] exact match in snippet view article find links to article

for resistance to ionizing radiation. The DNA mismatch repair protein PpMSH2 is a central component of the P. patens mismatch repair pathway that targets

Mannose receptor C-type 1 (679 words) [view diff] exact match in snippet view article find links to article

E, Lam PW, Tse CW, Lee KC, Lau CW, Gwi E, Leung SY, Yuen ST (May 2004). "MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary

Carcinogenesis (13,948 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079

Bert Vogelstein (3,823 words) [view diff] exact match in snippet view article find links to article

localization soon led them and other groups to identify repair genes such as MSH2 and MLH1 that are responsible for most cases of this syndrome. In the early

Glioma (6,374 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079

Holliday junction (3,885 words) [view diff] case mismatch in snippet view article find links to article

(2014). "Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc

Human genome (10,151 words) [view diff] exact match in snippet view article find links to article

coli) 1:3500 APC Lynch syndrome 5–10% of all cases of bowel cancer MLH1, MSH2, MSH6, PMS2 Fanconi anemia 1:130000 births FANCC Neurological conditions

Male breast cancer (4,641 words) [view diff] exact match in snippet view article find links to article

syndrome with mutations in any of the four DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2), or the EpCAM gene. The relative risks of men vs. women with

Myc (6,709 words) [view diff] exact match in snippet view article find links to article

(February 2003). "Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX". Oncogene. 22 (6): 819–25. doi:10.1038/sj.onc.1206252

Peter Propping (1,405 words) [view diff] exact match in snippet view article find links to article

E. Mangold, . . . P. Propping: Spectrum and frequenciens of mutations in MSH2 and MLH1 in 1721 German families suspected of hereditary nonpolyposis colorectal

Synthetic lethality (2,802 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079

Histone (9,575 words) [view diff] exact match in snippet view article find links to article

Trimethylation of H3 lysine 36 (H3K36me3) H3K36me3 has the ability to recruit the MSH2-MSH6 (hMutSα) complex of the DNA mismatch repair pathway. Consistently, regions

Epigenetics (18,430 words) [view diff] exact match in snippet view article find links to article

with H2O2 for 30 minutes causes the mismatch repair protein heterodimer MSH2-MSH6 to recruit DNA methyltransferase 1 (DNMT1) to sites of some kinds of

Owen Sansom (1,888 words) [view diff] case mismatch in snippet view article find links to article

neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice". Cancer Research. 61 (19): 7060–4. PMID 11585736. Archived from

RAD9A (3,997 words) [view diff] exact match in snippet view article find links to article

number of key interactions with mismatch repair protein complexes MLH1, MSH2, MSH3, and MSH6. Also, it has known interaction in the following repair mechanisms:

DNA methylation in cancer (3,792 words) [view diff] exact match in snippet view article find links to article

Park CS, Juhng SW, Lee JH (2011). "Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence"

POLD1 (7,977 words) [view diff] exact match in snippet view article find links to article

For example, germline mutations in DNA repair proteins involved in MMR (MSH2, MLH1, MSH6, and PMS2) have been described in Lynch syndrome (LS), which

Trinucleotide repeat expansion (7,971 words) [view diff] exact match in snippet view article find links to article

Jérôme; te Riele, Hein; Junien, Claudine; Gourdon, Geneviève (January 2004). "MSH2-Dependent Germinal CTG Repeat Expansions Are Produced Continuously in Spermatogonia