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searching for Synthetic lethality 25 found (52 total)

alternate case: synthetic lethality

Leflunomide (1,850 words) [view diff] exact match in snippet view article find links to article

suppressor, PTEN, loss. In PTEN negative tumors, leflunomide causes synthetic lethality potentially due to increased demand on pyrimidines in these faster
Epistasis and functional genomics (1,930 words) [view diff] exact match in snippet view article find links to article
genetic interactions. Synthetic genetic arrays (SGA), diploid based synthetic lethality analysis on microarrays (dSLAM), and epistatic miniarray profiles
Syrosingopine (279 words) [view diff] exact match in snippet view article find links to article
diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to
Diana Hargreaves (983 words) [view diff] exact match in snippet view article find links to article
Shokhirev MN, Benner C, Hargreaves DC. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Elife. 2017 Oct 2;6
PARP inhibitor (1,757 words) [view diff] exact match in snippet view article find links to article
pp.859-870 Lord CJ, Ashworth A (March 2017). "PARP inhibitors: Synthetic lethality in the clinic". Science. 355 (6330): 1152–1158. doi:10.1126/science
PRKCI (1,710 words) [view diff] exact match in snippet view article find links to article
Liu J, Fang B (Sep 2008). "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota". Cancer Research. 68 (18): 7403–8
ATM serine/threonine kinase (5,040 words) [view diff] exact match in snippet view article find links to article
C, Petermann E, et al. (February 2016). "ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic
MAFF (gene) (1,839 words) [view diff] exact match in snippet view article
Shavit JA, Motohashi H, Yamamoto M, Engel JD (Mar 2000). "Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice". The
Olaparib (1,885 words) [view diff] exact match in snippet view article find links to article
Cancer Research. 25 July 2005. "Olaparib: realising the promise of synthetic lethality". Cancer Research UK. 16 July 2015. "PARP inhibitors: Halting cancer
Poly (ADP-ribose) polymerase (3,041 words) [view diff] exact match in snippet view article
homologous recombination repair (HRR) is defective, and leading to the synthetic lethality of PARP inhibitors in HRR-defective cancer. HRR defects are classically
MAFK (2,533 words) [view diff] exact match in snippet view article find links to article
Shavit JA, Motohashi H, Yamamoto M, Engel JD (Mar 2000). "Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice". The
DNA repair (13,771 words) [view diff] exact match in snippet view article find links to article
the latter approach has been termed 'synthetic lethality'. Perhaps the most well-known of these 'synthetic lethality' drugs is the poly(ADP-ribose) polymerase
Simon N. Powell (1,366 words) [view diff] case mismatch in snippet view article find links to article
Meeting, Radiation Research Society, Oceans of Opportunity" (PDF). Synthetic Lethality and Repair Targeting: New Opportunities for Treatment. Radiation
National Cancer Institute (2,510 words) [view diff] case mismatch in snippet view article find links to article
Barrett's Esophagus Translational Research Network, New Approaches to Synthetic Lethality for Mutant KRAS-Dependent Cancers, Molecular and Cellular Characterization
MAFG (2,627 words) [view diff] exact match in snippet view article find links to article
Shavit JA, Motohashi H, Yamamoto M, Engel JD (Mar 2000). "Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice". The
Mullard Award (1,023 words) [view diff] exact match in snippet view article find links to article
Stephen Jackson "for pioneering research on DNA repair mechanisms and synthetic lethality that led to the discovery of olaparib, which has reached blockbuster
Tim Stearns (900 words) [view diff] exact match in snippet view article find links to article
defining genetic interactions and for the first time used the term "synthetic lethality" in the modern sense of two non-lethal mutations resulting in lethality
Functional genomics (3,747 words) [view diff] exact match in snippet view article find links to article
of multi-protein complexes. This approach can be used to identify synthetic lethality by using the appropriate genetic background. CRISPRi and CRISPRa
CHEK1 (3,416 words) [view diff] exact match in snippet view article find links to article
treatment with Chk1 inhibition enhances targeted cell death and provides synthetic lethality. Many cancers rely on Chk1 mediated cell cycle arrest heavily especially
Jenny Bryan (1,227 words) [view diff] exact match in snippet view article find links to article
animal Caenorhabditis elegans to test genetic interactions causing synthetic lethality in somatic cells, and a novel yeast-based model to search for modifier
KRAS (4,257 words) [view diff] exact match in snippet view article find links to article
Liu J, Fang B (Sep 2008). "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota". Cancer Research. 68 (18): 7403–8
CCNF (2,232 words) [view diff] exact match in snippet view article find links to article
D'Angiolella V (August 2019). "E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition". The EMBO Journal. 38
Metabolic network modelling (5,271 words) [view diff] exact match in snippet view article find links to article
same species as well as between different organisms. Analysis of synthetic lethality Predict adaptive evolution outcomes Use in metabolic engineering
Small Maf (3,041 words) [view diff] exact match in snippet view article find links to article
14.2164. PMC 317009. PMID 9679061. Onodera, K (2000). "Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice". EMBO
Transposon sequencing (1,748 words) [view diff] exact match in snippet view article find links to article
considered[citation needed]. These gene networks can be studied by screening for synthetic lethality and gene interactions where a double mutant shows an unexpected fitness