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Longer titles found: Histone-arginine N-methyltransferase (view), Histone-like nucleoid-structuring protein (view), Histone-modifying enzymes (view), Histone 3′ UTR stem-loop (view), Histone Database (view), Histone H1 (view), Histone H2A (view), Histone H2A.Z (view), Histone H2B (view), Histone H2B type 1-C (view), Histone H3 (view), Histone H4 (view), Histone acetylation and deacetylation (view), Histone acetyltransferase (view), Histone cluster 2 h3 family member d (view), Histone code (view), Histone deacetylase (view), Histone deacetylase 2 (view), Histone deacetylase 5 (view), Histone deacetylase inhibitor (view), Histone demethylase (view), Histone fold (view), Histone methylation (view), Histone methyltransferase (view), Histone octamer (view), Histone variants (view), Anti-histone antibodies (view), Non-histone protein (view), Linker histone H1 variants (view), ASF1 like histone chaperone (view), Alkb homolog 1, histone h2a dioxygenase (view), NuA4 histone acetyltransferase complex (view)

searching for Histone 184 found (2207 total)

alternate case: histone

JARID1B (1,066 words) [view diff] exact match in snippet view article find links to article

Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene. JARID1B
JADE1 (5,937 words) [view diff] exact match in snippet view article find links to article
recognize and bind specific methylated lysine of histone H3, which defined these domains as epigenetic histone code readers. Reviews describing structure and
HMGN2 (860 words) [view diff] exact match in snippet view article find links to article
Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene. High mobility group protein HMG14 and HMG17 HMGN1 (HMG-14)
KDM5A (1,597 words) [view diff] exact match in snippet view article find links to article
found for this gene. The Drosophila homolog, LID, was found to be an H3K4 histone demethylase that binds to c-Myc. It was recently renamed to Lysine Demethylase
PHF20 (329 words) [view diff] exact match in snippet view article find links to article
function histone acetyltransferase activity (H4-K8 specific) DNA binding histone acetyltransferase activity (H4-K5 specific) metal ion binding histone acetyltransferase
KDM5C (852 words) [view diff] exact match in snippet view article find links to article
"The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases". Cell. 128 (6): 1077–88. doi:10.1016/j.cell.2007
PHF20 (329 words) [view diff] exact match in snippet view article find links to article
function histone acetyltransferase activity (H4-K8 specific) DNA binding histone acetyltransferase activity (H4-K5 specific) metal ion binding histone acetyltransferase
KDM5D (1,080 words) [view diff] exact match in snippet view article find links to article
"The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases". Cell. 128 (6): 1077–88. doi:10.1016/j.cell.2007
KMT2C (1,128 words) [view diff] exact match in snippet view article find links to article
protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. Alternate
PHF16 (590 words) [view diff] exact match in snippet view article find links to article
component histone acetyltransferase complex Biological process histone H4-K16 acetylation histone H4-K8 acetylation histone H4-K12 acetylation histone H3 acetylation
KDM5C (852 words) [view diff] exact match in snippet view article find links to article
"The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases". Cell. 128 (6): 1077–88. doi:10.1016/j.cell.2007
MEF2D (1,264 words) [view diff] exact match in snippet view article find links to article
MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10
ING2 (955 words) [view diff] exact match in snippet view article find links to article
ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair
RPS6KA4 (643 words) [view diff] exact match in snippet view article find links to article
"MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. PMC 156769
POLE3 (567 words) [view diff] exact match in snippet view article find links to article
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein
Bryan M. Turner (238 words) [view diff] exact match in snippet view article find links to article
the histone marks. These novel tools allowed him to link histone deacetylation to gene silencing via the discovery that chromosome-wide histone deacetylation
ING4 (1,425 words) [view diff] exact match in snippet view article find links to article
remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent
Major histocompatibility complex (6,686 words) [view diff] no match in snippet view article find links to article
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface
Testicular receptor 2 (925 words) [view diff] exact match in snippet view article find links to article
PMID 12093804. Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2"
JARID2 (1,474 words) [view diff] exact match in snippet view article find links to article
methylated histone binding histone demethylase activity (H3-trimethyl-K4 specific) Cellular component ESC/E(Z) complex nucleoplasm nucleus histone methyltransferase
HR (gene) (1,037 words) [view diff] exact match in snippet view article
as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Variations in this gene are involved in low levels of hair
SIN3B (1,096 words) [view diff] exact match in snippet view article find links to article
Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes
NFYB (1,231 words) [view diff] exact match in snippet view article find links to article
specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of
PHF1 (435 words) [view diff] exact match in snippet view article find links to article
stimulus regulation of histone methylation negative regulation of gene expression, epigenetic positive regulation of histone H3-K27 methylation chromatin
ING1 (1,404 words) [view diff] exact match in snippet view article find links to article
D, Riabowol K (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–9. doi:10
GFI1 (1,248 words) [view diff] exact match in snippet view article find links to article
Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1". Mol. Cell. Biol. 25 (23): 10338–51
PHF10 (523 words) [view diff] exact match in snippet view article find links to article
binding metal ion binding histone acetyltransferase activity histone binding Cellular component nucleus npBAF complex histone acetyltransferase complex
Polyuridylation (99 words) [view diff] exact match in snippet view article find links to article
group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving
KAT2A (1,220 words) [view diff] exact match in snippet view article find links to article
Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene. GCN5L2 has been shown to interact with: DDB1, Ku70, Ku80, TADA2L
MEF2B (1,156 words) [view diff] exact match in snippet view article find links to article
Goya R, Mungall KL, Corbett RD, et al. (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma" (PDF). Nature. 476 (7360): 298–303
HIST2H3C (1,133 words) [view diff] exact match in snippet view article find links to article
Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
Computational epigenetics (1,203 words) [view diff] exact match in snippet view article find links to article
The Histone Database Contains 254 sequences from histone H1, 383 from histone H2, 311 from histone H2B, 1043 from histone H3 and 198 from histone H4,
SETDB1 (2,001 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase
MTA1 (3,868 words) [view diff] exact match in snippet view article find links to article
revealed the role of MTA1 in interactions with modified or unmodified histone and non-histone proteins, chromatin remodeling, and modulation of gene transcription
RBBP7 (1,727 words) [view diff] exact match in snippet view article find links to article
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. This protein is a ubiquitously expressed nuclear protein and belongs
SETD7 (655 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene. GRCh38: Ensembl release 89: ENSG00000145391 - Ensembl
HIST1H4I (930 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that, in humans, is encoded by the HIST1H4I gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
HIST2H2BE (1,161 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene. Histones are basic nuclear proteins that are responsible for the nucleosome
KAT8 regulatory NSL complex subunit 1 (703 words) [view diff] exact match in snippet view article find links to article
function histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K16 specific) GO:0001948 protein binding histone acetyltransferase
Lepidopsocidae (304 words) [view diff] exact match in snippet view article find links to article
partial sequences of the nuclear 18S rDNA, mitochondrial 16S rDNA, and Histone 3 genes, propose that Lepidopsocidae is monophyletic, meaning that the
ATM serine/threonine kinase (5,040 words) [view diff] exact match in snippet view article find links to article
together. ATM directly interacts with the NBS1 subunit and phosphorylates the histone variant H2AX on Ser139. This phosphorylation generates binding sites for
HIST1H2BK (965 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene. Histones are basic nuclear proteins that are responsible for the nucleosome
RBBP7 (1,727 words) [view diff] exact match in snippet view article find links to article
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. This protein is a ubiquitously expressed nuclear protein and belongs
Sp2 transcription factor (795 words) [view diff] exact match in snippet view article find links to article
involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc
H3F3A (1,299 words) [view diff] exact match in snippet view article find links to article
Histone H3.3 is a protein that in humans is encoded by the H3F3A and H3F3B genes. It plays an essential role in maintaining genome integrity during mammalian
KDM3B (639 words) [view diff] exact match in snippet view article find links to article
metal ion binding histone demethylase activity GO:0000975 transcription cis-regulatory region binding chromatin DNA binding histone demethylase activity
Lymphoid enhancer-binding factor 1 (1,611 words) [view diff] exact match in snippet view article find links to article
DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding armadillo repeat domain binding estrogen receptor binding
HIST1H1A (921 words) [view diff] exact match in snippet view article find links to article
Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene. Histones are basic nuclear proteins responsible for nucleosome structure of the
MEF2C (1,886 words) [view diff] exact match in snippet view article find links to article
Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (Nov 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular
HIST1H4E (458 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that in humans is encoded by the HIST1H4E gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
KDM4A (1,585 words) [view diff] exact match in snippet view article find links to article
trimethylation-specific demethylase, converting specific trimethylated histone on histone H3 lysine 9 and 36 residues to the dimethylated form and lysine 9
HIST1H4I (930 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that, in humans, is encoded by the HIST1H4I gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
HIST1H3E (590 words) [view diff] exact match in snippet view article find links to article
Histone H3.1 is a protein that in humans is encoded by the HIST1H3E gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
HIST1H3A (859 words) [view diff] exact match in snippet view article find links to article
Histone H3.1 is a protein in humans that is encoded by the HIST1H3A gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
SETD7 (655 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene. GRCh38: Ensembl release 89: ENSG00000145391 - Ensembl
HIST1H4A (678 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that in humans is encoded by the HIST1H4A gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate (315 words) [view diff] exact match in snippet view article find links to article
oxidative stress, MEcPP accumulates in certain bacteria. MEcPP releases histone-like proteins from DNA, triggering nucleoid decondensation in Chlamydia
SUZ12 (1,209 words) [view diff] exact match in snippet view article find links to article
Lopez-Corrales N, Cibelli JB (December 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development"
WDR5 (1,110 words) [view diff] exact match in snippet view article find links to article
Michael L (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression".
FOXP3 (3,446 words) [view diff] exact match in snippet view article find links to article
depending on what specific transcriptional factors such as deacetylases and histone acetylases are acting on it. The Foxp3 gene is also known to convert naïve
Epigenetic code (175 words) [view diff] exact match in snippet view article find links to article
epigenetic modification in each cell. It consists of histone modifications defined by the histone code and additional epigenetic modifications such as
ZBTB32 (1,629 words) [view diff] exact match in snippet view article find links to article
immune cell tumorigenesis or immune cell development. The protein recruits histone modification enzymes to chromatin to affect gene activation. ZBTB32 recruits
UBE2B (964 words) [view diff] exact match in snippet view article find links to article
ubiquitination histone lysine demethylation protein K48-linked ubiquitination negative regulation of histone phosphorylation regulation of histone modification
HIST1H2BF (556 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BF gene. Histones are basic nuclear proteins that are responsible for
MAPK8 (1,818 words) [view diff] exact match in snippet view article find links to article
1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell Sci. 108
Protein kinase N1 (1,755 words) [view diff] exact match in snippet view article find links to article
nucleotide binding protein kinase C activity histone binding histone deacetylase binding chromatin binding histone kinase activity (H3-T11 specific) kinase
EIF3A (1,357 words) [view diff] exact match in snippet view article find links to article
dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89
HIST1H2AA (681 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST2H2BE (1,161 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene. Histones are basic nuclear proteins that are responsible for the nucleosome
SUV420H1 (671 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SUV420H1 is an enzyme that in humans is encoded by the SUV420H1 gene. The enzyme along with WHSC1 is responsible for
HIST1H3G (514 words) [view diff] exact match in snippet view article find links to article
Histone H3.1 is a protein that in humans is encoded by the HIST1H3G gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
HIST1H2BJ (908 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 1-J is a protein that in humans is encoded by the HIST1H2BJ gene. Histones are basic nuclear proteins that are responsible for the nucleosome
NSD1 (299 words) [view diff] exact match in snippet view article find links to article
SET Domain Protein 1)is a transcription coregulator protein that encodes Histone Methyltransferase and is associated with Sotos syndrome and Weaver syndrome
SUV39H2 (545 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene. GRCh38: Ensembl release 89: ENSG00000152455 - Ensembl
HIST1H2BK (965 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST1H4D (569 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that in humans is encoded by the HIST1H4D gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
ACSS2 (678 words) [view diff] exact match in snippet view article find links to article
linked to histone acetylation and gene regulation. In mouse neurons, Mews et al. identified a major role for the ACSS2 pathway to regulate histone acetylation
ORC1 (1,433 words) [view diff] exact match in snippet view article find links to article
phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MYST2/HBO1), a protein involved in control of transcription
TNP2 (535 words) [view diff] exact match in snippet view article find links to article
1016/S0021-9258(17)45324-5. PMID 2250010. "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)". Schlüter G, Kremling H, Engel W (1992). "The
MBD3 (1,442 words) [view diff] exact match in snippet view article find links to article
remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase
CDY1 (752 words) [view diff] exact match in snippet view article find links to article
where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the
HIST1H4H (472 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that in humans is encoded by the HIST1H4H gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
Succinic acid (4,234 words) [view diff] exact match in snippet view article find links to article
reduces the activity of 2-oxoglutarate-dependent dioxygenases, including histone and DNA demethylases, prolyl hydroxylases and collagen prolyl-4-hydroxylases
RE1-silencing transcription factor (2,007 words) [view diff] exact match in snippet view article find links to article
(November 1999). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes". Proceedings
RE1-silencing transcription factor (2,007 words) [view diff] exact match in snippet view article find links to article
(November 1999). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes". Proceedings
EIF3A (1,357 words) [view diff] exact match in snippet view article find links to article
dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89
Tazemetostat (731 words) [view diff] exact match in snippet view article find links to article
of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated
SUV39H2 (545 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene. GRCh38: Ensembl release 89: ENSG00000152455 - Ensembl
Succinic acid (4,234 words) [view diff] exact match in snippet view article find links to article
reduces the activity of 2-oxoglutarate-dependent dioxygenases, including histone and DNA demethylases, prolyl hydroxylases and collagen prolyl-4-hydroxylases
HIST2H2BF (409 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 2-F is a protein that in humans is encoded by the HIST2H2BF gene. GRCh38: Ensembl release 89: ENSG00000203814 - Ensembl, May 2017 "Human
RBBP5 (864 words) [view diff] exact match in snippet view article find links to article
Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression".
KDM4C (1,019 words) [view diff] exact match in snippet view article find links to article
trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased
ASH2L (736 words) [view diff] exact match in snippet view article find links to article
Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene. ASH2L has been shown to interact with
WHSC1L1 (623 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene. This gene is related to the Wolf-Hirschhorn syndrome
Cyclin-dependent kinase 9 (1,391 words) [view diff] exact match in snippet view article find links to article
polymerase II phosphorylation positive regulation of histone phosphorylation positive regulation of histone H2B ubiquitination positive regulation of transcription
Kruppel-like factors (2,098 words) [view diff] exact match in snippet view article find links to article
and 2. CtBP in turn recruits histone modifying enzymes. It brings in histone deacetylases, histone demethylases and histone methylases, which are thought
KDM4B (590 words) [view diff] exact match in snippet view article find links to article
Nottke A, Lan F, et al. (2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10
Arrestin beta 1 (1,489 words) [view diff] exact match in snippet view article find links to article
function GO:0005097, GO:0005099, GO:0005100 GTPase activator activity histone acetyltransferase activity GO:0048551 enzyme inhibitor activity insulin-like
ING5 (455 words) [view diff] exact match in snippet view article find links to article
remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent
HIST1H3J (479 words) [view diff] exact match in snippet view article find links to article
Histone H3.1 is a protein that in humans is encoded by the HIST1H3J gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
TNP2 (535 words) [view diff] exact match in snippet view article find links to article
1016/S0021-9258(17)45324-5. PMID 2250010. "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)". Schlüter G, Kremling H, Engel W (1992). "The
EZH1 (691 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene. In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation
Exonuclease (1,418 words) [view diff] exact match in snippet view article find links to article
type endonuclease is known to be essential for the proper processing of histone pre-mRNA, in which U7 snRNP directs the single cleavage process. Following
UBE2N (1,070 words) [view diff] exact match in snippet view article find links to article
pathway global genome nucleotide-excision repair positive regulation of histone modification cellular protein modification process positive regulation
HIST3H3 (987 words) [view diff] exact match in snippet view article find links to article
Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
Mef2 (1,901 words) [view diff] exact match in snippet view article find links to article
factors shows member-specific features and mediates the nuclear import of histone deacetylase 4". J Cell Sci. 114 (Pt 24): 4477–83. doi:10.1242/jcs.114.24
HIST1H3D (515 words) [view diff] exact match in snippet view article find links to article
Histone H3.1 is a protein that in humans is encoded by the HIST1H3D gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
USP22 (526 words) [view diff] exact match in snippet view article find links to article
chromosome 17. USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. GRCh38:
KAT6B (1,031 words) [view diff] exact match in snippet view article find links to article
Vezmar M, Yang Y, Heng HH, Yang XJ (Nov 1999). "Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein". J
Transcription initiation protein SPT3 homolog (1,037 words) [view diff] exact match in snippet view article find links to article
T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10
Acute myeloblastic leukemia with maturation (3,154 words) [view diff] exact match in snippet view article find links to article
2005). DEK functions as a transcriptional repressor by interfering with histone acetyl transferases, regulator for a number of stem cells, and activates
ORC1 (1,433 words) [view diff] exact match in snippet view article find links to article
phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MYST2/HBO1), a protein involved in control of transcription
SUV420H1 (671 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase SUV420H1 is an enzyme that in humans is encoded by the SUV420H1 gene. The enzyme along with WHSC1 is responsible for
PADI4 (1,092 words) [view diff] exact match in snippet view article find links to article
PADI4 plays a role in the epigenetics, the deimination of arginines on histones 3 and 4 can act antagonistically to arginine methylation (Chromatin modifications
HIST1H2AD (522 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1-D is a protein that in humans is encoded by the HIST1H2AD gene. Histones are basic nuclear proteins that are responsible for the nucleosome
Sirtuin 6 (1,028 words) [view diff] exact match in snippet view article find links to article
homologs to the yeast Sir2 protein. Sirt6 is mainly known as a deacetylase of histones H3 and H4, an activity by which it changes chromatin density and regulates
HIST1H2AB (807 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene. Histones are basic nuclear proteins that are responsible for the
CAMK1 (992 words) [view diff] exact match in snippet view article find links to article
Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature. 408 (6808): 106–11
HIST1H2AL (677 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene. Histones are basic nuclear proteins that are responsible for the nucleosome
Twist-related protein 1 (2,284 words) [view diff] exact match in snippet view article find links to article
Puri PL, Wu HY, Wang JY, Nakatani Y, Kedes L (Feb 1999). "Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral
KRT23 (524 words) [view diff] exact match in snippet view article find links to article
2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells"
ACSS2 (678 words) [view diff] exact match in snippet view article find links to article
linked to histone acetylation and gene regulation. In mouse neurons, Mews et al. identified a major role for the ACSS2 pathway to regulate histone acetylation
HIST4H4 (928 words) [view diff] exact match in snippet view article find links to article
Histone H4 is a protein that in humans is encoded by the HIST4H4 gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
TAF5L (803 words) [view diff] exact match in snippet view article find links to article
gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20
HIST1H2AG (588 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AG gene. Histones are basic nuclear proteins that are responsible for the nucleosome
ASF1A (1,216 words) [view diff] exact match in snippet view article find links to article
Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene. This gene encodes a member of the H3/H4 family of histone chaperone
TAF6L (773 words) [view diff] exact match in snippet view article find links to article
component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which
HIST1H2BN (838 words) [view diff] exact match in snippet view article find links to article
Histone H2B type 1-N is a protein that in humans is encoded by the HIST1H2BN gene. Histones are basic nuclear proteins that are responsible for the nucleosome
ASF1B (778 words) [view diff] exact match in snippet view article find links to article
Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene. This gene encodes a member of the H3/H4 family of histone chaperone
HIST1H2AJ (554 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1-J is a protein that in humans is encoded by the HIST1H2AJ gene. Histones are basic nuclear proteins that are responsible for the nucleosome
KDM4D (400 words) [view diff] exact match in snippet view article find links to article
Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10
KAT6A (975 words) [view diff] exact match in snippet view article find links to article
Information, U.S. National Library of Medicine. "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3". Borrow J, Stanton VP, Andresen
HIST1H4G (465 words) [view diff] exact match in snippet view article find links to article
Histone H4-like protein type G is a protein that in humans is encoded by the HIST1H4G gene. Histones are basic nuclear proteins that are responsible for
ING5 (455 words) [view diff] exact match in snippet view article find links to article
remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent
TAF6L (773 words) [view diff] exact match in snippet view article find links to article
component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which
C-Fos (3,896 words) [view diff] exact match in snippet view article find links to article
which induces its association with the histone acetyltransferase, CREB binding protein (CBP) to acetylate histones and facilitate gene activation. This
SUDS3 (438 words) [view diff] exact match in snippet view article find links to article
Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene. SDS3 is a subunit of the histone deacetylase
HIST1H2AI (461 words) [view diff] exact match in snippet view article find links to article
Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene. Histones are basic nuclear proteins that are responsible for the nucleosome
Tazemetostat (731 words) [view diff] exact match in snippet view article find links to article
of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated
Alpha-thalassemia mental retardation syndrome (1,005 words) [view diff] exact match in snippet view article find links to article
alpha-globin gene cluster. Together they are all responsible for depositing the histone H3.3 at telomeric and pericentromeric regions. They are also responsible
HIST1H1D (680 words) [view diff] exact match in snippet view article find links to article
Histone H1.3 is a protein that in humans is encoded by the HIST1H1D gene. Histones are basic nuclear proteins responsible for nucleosome structure of the
Mef2 (1,901 words) [view diff] exact match in snippet view article find links to article
factors shows member-specific features and mediates the nuclear import of histone deacetylase 4". J Cell Sci. 114 (Pt 24): 4477–83. doi:10.1242/jcs.114.24
MIZF (761 words) [view diff] exact match in snippet view article find links to article
Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene. HINFP is a protein that binds to a highly conserved DNA motif
Enzyme modulator (108 words) [view diff] exact match in snippet view article find links to article
modulators Others and non-receptor Enzymes: Cytochrome P450 modulators Histone deacetylase inhibitors Phosphodiesterase inhibitors Ion channels: Ion channel
UBE2N (1,070 words) [view diff] exact match in snippet view article find links to article
pathway global genome nucleotide-excision repair positive regulation of histone modification cellular protein modification process positive regulation
H2AFY2 (491 words) [view diff] exact match in snippet view article find links to article
Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene. GRCh38: Ensembl release 89: ENSG00000099284 - Ensembl, May 2017 GRCm38:
RUNX1T1 (1,732 words) [view diff] exact match in snippet view article find links to article
chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript
PADI4 (1,092 words) [view diff] exact match in snippet view article find links to article
PADI4 plays a role in the epigenetics, the deimination of arginines on histones 3 and 4 can act antagonistically to arginine methylation (Chromatin modifications
Retinoblastoma-like protein 2 (1,523 words) [view diff] exact match in snippet view article find links to article
family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United
Ru-Chih Chow Huang (1,029 words) [view diff] exact match in snippet view article find links to article
functions for nuclear histones in the early 1960s when the field lacked a consensus on types and functions of individual histone proteins. Later she made
ING3 (659 words) [view diff] exact match in snippet view article find links to article
"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc
KDM4C (1,019 words) [view diff] exact match in snippet view article find links to article
trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased
CABIN1 (1,064 words) [view diff] exact match in snippet view article find links to article
MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10
WHSC1L1 (623 words) [view diff] exact match in snippet view article find links to article
Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene. This gene is related to the Wolf-Hirschhorn syndrome
WHSC1 (982 words) [view diff] exact match in snippet view article find links to article
Probable histone-lysine N-methyltransferase NSD2 is an enzyme that in humans is encoded by the WHSC1 gene. This gene encodes a protein that contains four
Transcription initiation protein SPT3 homolog (1,037 words) [view diff] exact match in snippet view article find links to article
T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10
Epigenetic therapy (2,711 words) [view diff] exact match in snippet view article find links to article
chromatin and repress the related genes. The second category is histone modifications. Histones are proteins which are involved in the folding and compaction
KRT23 (524 words) [view diff] exact match in snippet view article find links to article
2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells"
ZNF451 (504 words) [view diff] exact match in snippet view article find links to article
sequence-specific DNA binding Cellular component PML body nucleus nucleoplasm histone methyltransferase complex Biological process negative regulation of transcription
Polycomb-group proteins (1,471 words) [view diff] exact match in snippet view article find links to article
PRC2 catalyzes trimethylation of lysine 27 on histone H3 (H3K27me2/3), while PRC1 mono- ubiquitinates histone H2A on lysine 119 (H2AK119Ub1). In mammals
SUDS3 (438 words) [view diff] exact match in snippet view article find links to article
Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene. SDS3 is a subunit of the histone deacetylase
TAF6L (773 words) [view diff] exact match in snippet view article find links to article
component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which
Ataxin 3 (1,537 words) [view diff] exact match in snippet view article find links to article
Li F, Macfarlan T, Pittman RN, Chakravarti D (Nov 2002). "Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities"
Retinoblastoma-like protein 2 (1,523 words) [view diff] exact match in snippet view article find links to article
family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United
Protein phosphorylation (7,845 words) [view diff] exact match in snippet view article find links to article
certain enzymes and proteins. Post-translational modification of histones such as histone phosphorylation has been shown to modify the chromatin structure
GTF3C1 (795 words) [view diff] exact match in snippet view article find links to article
multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704
KDM4D (400 words) [view diff] exact match in snippet view article find links to article
Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10
MORF4L2 (793 words) [view diff] exact match in snippet view article find links to article
"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc
PAXIP1 (768 words) [view diff] exact match in snippet view article find links to article
Kalkum M, Ge K (2007). "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex". J. Biol. Chem. 282 (28): 20395–406
KANSL3 (412 words) [view diff] exact match in snippet view article find links to article
Molecular function histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K16 specific) histone acetyltransferase activity
VRK1 (856 words) [view diff] exact match in snippet view article find links to article
therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor
MIZF (761 words) [view diff] exact match in snippet view article find links to article
Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene. HINFP is a protein that binds to a highly conserved DNA motif
Mir-137 (2,112 words) [view diff] exact match in snippet view article find links to article
targets via miRecords database. Among these targets, LSD1 (Lysine-specific histone demethylase 1A, also known as KDM1A) has been shown to be directly downregulated
Enzyme modulator (108 words) [view diff] exact match in snippet view article find links to article
modulators Others and non-receptor Enzymes: Cytochrome P450 modulators Histone deacetylase inhibitors Phosphodiesterase inhibitors Ion channels: Ion channel
Codrug (464 words) [view diff] exact match in snippet view article find links to article
various diseases. Codrug of butyric acid and ATRA, Codrug of ATRA and histone deacetylase inhibitors, 5-Fluorouracil (5-FU) and cytarabine (Ara-C) codrug
H2BFS (691 words) [view diff] exact match in snippet view article find links to article
Histone H2B type F-S is a protein that in humans is encoded by the H2BFS gene. GRCh38: Ensembl release 89: ENSG00000234289 - Ensembl, May 2017 "Human
CABIN1 (1,064 words) [view diff] exact match in snippet view article find links to article
MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10
SMYD3 (1,116 words) [view diff] exact match in snippet view article find links to article
et al. (April 2012). "Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation". Epigenetics. 7 (4): 340–3. doi:10.4161/epi.19506
MCRS1 (1,200 words) [view diff] exact match in snippet view article find links to article
ontology Molecular function poly(U) RNA binding histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K5 specific) poly(G)
Protein arginine methyltransferase 5 (2,032 words) [view diff] exact match in snippet view article find links to article
Messaoudi SM, Rodier G, Cam AL, Sardet C, Fabbrizio E (May 2008). "The histone‐binding protein COPR5 is required for nuclear functions of the protein
Autoimmune regulator (3,081 words) [view diff] exact match in snippet view article find links to article
read chromatin marks through the degree of methylation at the tail of histone H3. More specifically, PHD1 is able to recognize unmethylation at the H3
DNMT3L (1,063 words) [view diff] exact match in snippet view article find links to article
protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants
ZNF217 (962 words) [view diff] exact match in snippet view article find links to article
candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry
ZNF366 (871 words) [view diff] exact match in snippet view article find links to article
and represses ER activity through the association with RIP140, CtBP and histone deacetylases. In DCs, DC-SCRIPT was found to be highly expressed in type