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searching for MRN complex 7 found (24 total)

Homology directed repair (1,265 words) [view diff] exact match in snippet view article find links to article

suggested that before or while H2AX is involved with the repair pathway, the MRN complex (which consists of Mre11, Rad50 and NBS1) is attracted to the broken

Transformation/transcription domain-associated protein (1,492 words) [view diff] exact match in snippet view article find links to article

required for the mitotic checkpoint and normal cell cycle progression. The MRN complex (composed of MRE11, RAD50, and NBS1) is involved in the detection and

KIAA1958 (638 words) [view diff] exact match in snippet view article find links to article

SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates

Physcomitrella patens (2,426 words) [view diff] exact match in snippet view article find links to article

integrity. Genes Ppmre11 and Pprad50 of P. patens encode components of the MRN complex, the principal sensor of DNA double-strand breaks. These genes are necessary

Chromatin remodeling (5,523 words) [view diff] exact match in snippet view article find links to article

interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage". EMBO Rep. 9 (8): 795–801. doi:10.1038/embor

Chromosome instability (4,006 words) [view diff] exact match in snippet view article find links to article

which is a mutation in the damage response kinase ATM – and BRCA1 or MRN complex mutations that play a role in responding to DNA damage. When the above

BRCA1 (13,608 words) [view diff] exact match in snippet view article find links to article

DNA contributes to its ability to inhibit the nuclease activity of the MRN complex as well as the nuclease activity of Mre11 alone. This may explain a role