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Longer titles found: Apoptosis-antagonizing transcription factor (view), Apoptosis-inducing factor (view), Apoptosis-inducing factor, mitochondria-associated 3 (view), Apoptosis (album) (view), Inhibitor of apoptosis (view), Pseudoapoptosis (view), Cellular apoptosis susceptibility protein (view), Inhibitor of apoptosis domain (view), P53 upregulated modulator of apoptosis (view), TP53-inducible glycolysis and apoptosis regulator (view), Mitochondrial apoptosis-induced channel (view), UVB-induced apoptosis (view), Cellular Inhibitor of Apoptosis Protein 1 (view)

searching for Apoptosis 107 found (4627 total)

alternate case: apoptosis

AATK (726 words) [view diff] exact match in snippet view article find links to article

Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.
Decoy receptor 1 (978 words) [view diff] exact match in snippet view article find links to article
capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found
LIGHT (protein) (1,566 words) [view diff] exact match in snippet view article
and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte
ADP/ATP translocase 4 (1,607 words) [view diff] exact match in snippet view article find links to article
is encoded by the SLC25A31 gene on chromosome 4. This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and
Caspase 10 (1,469 words) [view diff] exact match in snippet view article find links to article
activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing
Ascoviridae (653 words) [view diff] exact match in snippet view article find links to article
host develops a unique cytopathology that resembles apoptosis. Cell infection induces apoptosis and in some species is associated with synthesis of a
Mir-26 microRNA precursor family (3,054 words) [view diff] exact match in snippet view article find links to article
mimic promoted significant and rapid death by apoptosis. mir-26a is proposed to promote this apoptosis by repressing expression of the BAG4/Silencer of
Cixutumumab (615 words) [view diff] exact match in snippet view article find links to article
PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine
Chelerythrine (1,070 words) [view diff] exact match in snippet view article find links to article
concentration in the mitochondria greatly alters its normal activity and leads to apoptosis signaling, and eventually cellular destruction. Other cellular transporters
Xiaodong Wang (biochemist) (318 words) [view diff] exact match in snippet view article
His laboratory developed an in-vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification
Bufotalin (817 words) [view diff] exact match in snippet view article find links to article
susceptibility to apoptosis via TNF-α signalling by the BH3 interacting domain death agonist and STAT proteins. Bufotalin induces apoptosis in vitro in human
CFLAR (275 words) [view diff] exact match in snippet view article find links to article
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE-like inhibitory protein).
MiR-338 (658 words) [view diff] exact match in snippet view article find links to article
interference. miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate
TUBA8 (844 words) [view diff] exact match in snippet view article find links to article
Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J.
Mir-34 microRNA precursor family (873 words) [view diff] exact match in snippet view article find links to article
regulate the cell cycle and apoptosis, respectively. Furthermore, miR-34 suppression of SIRT1 ultimately leads to apoptosis in WT human colon cancer cells
PAK2 (2,148 words) [view diff] exact match in snippet view article find links to article
both the cytoplasmic or nuclear compartments. PAK2 signaling modulates apoptosis, endothelial lumen formation, viral pathogenesis, and cancer including
Deoxyribonuclease II (386 words) [view diff] exact match in snippet view article find links to article
shown that a mutation in this enzyme of mice leads to DNA degradation by apoptosis. DNase II beta (also called DLAD, or DNase II-Like Acid DNase), which
Fumonisin B1 (3,188 words) [view diff] exact match in snippet view article find links to article
either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity
Thyroid hormones (4,670 words) [view diff] exact match in snippet view article find links to article
diffuses into the nucleus. Thyroxine and iodine stimulate the spectacular apoptosis of the cells of the larval gills, tail and fins in amphibian metamorphosis
Drozitumab (100 words) [view diff] exact match in snippet view article find links to article
for the treatment of cancers. It targets Tumour Necrosis Factor Related Apoptosis-inducing Ligand (TRAIL), whose receptors are found on the surface of many
Citrinin (4,121 words) [view diff] exact match in snippet view article find links to article
Nephropathy. The interaction of both substances might also influence apoptosis and necrosis in hepatocytes. The existing information on occurrence of
TUBA1C (797 words) [view diff] exact match in snippet view article find links to article
Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J.
VDAC3 (2,533 words) [view diff] exact match in snippet view article find links to article
this term was replaced by apoptosis to emphasize its role opposite mitosis in tissue kinetics. In later stages of apoptosis the entire cell becomes fragmented
Inositol phosphate (300 words) [view diff] exact match in snippet view article find links to article
play crucial roles in diverse cellular functions, such as cell growth, apoptosis, cell migration, endocytosis, and cell differentiation. The group comprises:
ARAF (1,985 words) [view diff] exact match in snippet view article find links to article
not found in the MAPK pathway. By inhibiting MST2, A-Raf can prevent apoptosis from occurring. However, this inhibition is only possible when the splice
Beta-bungarotoxin (366 words) [view diff] exact match in snippet view article find links to article
(P00989) and B3 (Q75S50). The B chain plays a functional role in inducing apoptosis. The target of this neurotoxin is at the presynaptic terminal, where it
CDC2L1 (1,090 words) [view diff] exact match in snippet view article find links to article
could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported
ADP/ATP translocase 3 (994 words) [view diff] exact match in snippet view article find links to article
(2004). "Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells". FEBS Lett. 563 (1–3): 155–60. doi:10.1016/S0014-5793(04)00293-5
Vpr (639 words) [view diff] exact match in snippet view article find links to article
cells such as macrophages. Vpr also induces G2 cell cycle arrest and apoptosis in proliferating cells, which can result in immune dysfunction. Vpr is
Inositol trisphosphate receptor (628 words) [view diff] exact match in snippet view article find links to article
physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate
Solasonine (255 words) [view diff] exact match in snippet view article find links to article
There is a loss of membrane integrity which puts the cell at risk for apoptosis (cell death) due to the ability of any chemical coming into contact with
MAPK14 (5,241 words) [view diff] exact match in snippet view article find links to article
TGFβ-activated kinase (TAK1), TAO1-3, mixed-lineage kinase 2/3 (MLK2/3), and apoptosis signal-regulating kinase 1/2 (ASK1/2), as well as MAP2Ks, such as MKK3
Nerve tissue protein (1,058 words) [view diff] exact match in snippet view article find links to article
sciatic nerves. Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), these proteins
Oropouche orthobunyavirus (559 words) [view diff] exact match in snippet view article find links to article
HeLa cells to study the mechanisms of apoptosis induced by the virus. It was found that OROV causes apoptosis by DNA fragmentation. In UV-inactivated
Farnesyltransferase inhibitor (1,079 words) [view diff] exact match in snippet view article find links to article
apoptosis in certain cancerous cell lines. 192185-72-1 Gingerol Gingerol shown to activate SERCA (cardiac and skeletal SR Ca2+-ATPase) with apoptosis
Fenretinide (508 words) [view diff] exact match in snippet view article find links to article
accumulation of reactive oxygen species (ROS), resulting in cell death through apoptosis and/or necrosis. Fenretinide accumulates preferentially in fatty tissue
Thrombopoiesis (588 words) [view diff] exact match in snippet view article find links to article
granules, and soluble macromolecules in the cytoplasm are being consumed. Apoptosis also plays a role in the final stages of thrombopoiesis by letting proplatelet
Mycobacterium tuberculosis (7,263 words) [view diff] exact match in snippet view article find links to article
pathway in macrophages are controlled in this manner. As a result of having apoptosis being suppressed, it provides M. tuberculosis with a safe replicative
Neutrophil (4,818 words) [view diff] exact match in snippet view article find links to article
pneumoniae and Neisseria gonorrhoeae have been reported to delay neutrophil apoptosis. Thus, some bacteria—and those that are predominantly intracellular pathogens—can
Matrine (544 words) [view diff] exact match in snippet view article find links to article
vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities
NEU3 (1,111 words) [view diff] exact match in snippet view article find links to article
ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718–23. Bibcode:2002PNAS
TRIB1 (916 words) [view diff] exact match in snippet view article find links to article
regulatory role in the function of this pathway which mediates proliferation, apoptosis and differentiation in cells. Tribbles-1 is encoded by the trib1 gene
PRKCI (1,710 words) [view diff] exact match in snippet view article find links to article
BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped
BIRC6 (669 words) [view diff] exact match in snippet view article find links to article
inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating
K562 cells (1,374 words) [view diff] exact match in snippet view article find links to article
differentiation, and apoptosis. The growth of these leukemic cells are controlled by either initiating cell differentiation or apoptosis to occur. Cell differentiation
Inositol-phosphate phosphatase (2,363 words) [view diff] exact match in snippet view article find links to article
wide array of cell functions, including but not limited to, cell growth, apoptosis, secretion, and information processing. Inhibition of inositol monophosphatase
IGFBP3 (4,673 words) [view diff] exact match in snippet view article find links to article
IGFBP-7 binds IGF1R, which blocks IGF-1 and IGF-2 binding, resulting in apoptosis. IGFBP-3 was first isolated, characterized, and quantitated in human plasma
GPR65 (1,705 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor whose expression was induced during activation-induced apoptosis of T cells. The group sought to identify which genes were necessary during
TRIM28 (2,250 words) [view diff] exact match in snippet view article find links to article
differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. Its functionality is dependent upon post-translational modifications
DAPK1 (1,168 words) [view diff] exact match in snippet view article find links to article
kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis". Molecular and Cellular Biology. 20 (3): 1044–54. doi:10.1128/MCB.20
Mir-365 microRNA precursor family (888 words) [view diff] exact match in snippet view article find links to article
(March 2012). "Downregulation of BCL2 by miRNAs augments drug-induced apoptosis--a combined computational and experimental approach". Journal of Cell
NSP1 (rotavirus) (694 words) [view diff] exact match in snippet view article
function. NSP1 also inhibits activation of NFkappaB NSP1 inhibits cellular apoptosis by directly interacting p85 subunit of PI3K and thus activating PI3K/Akt
ACVR1C (894 words) [view diff] exact match in snippet view article find links to article
PMID 15489334. Xu G, Zhong Y, Munir S, et al. (2004). "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via
Titanocene Y (1,108 words) [view diff] exact match in snippet view article find links to article
literature under its trivial name of Titanocene Y. Titanocene Y is a cytotoxic apoptosis-inducing and anti-angiogenic drug candidate targeting renal-cell cancer
Proline oxidase (1,538 words) [view diff] exact match in snippet view article find links to article
Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525
BIRC7 (1,131 words) [view diff] exact match in snippet view article find links to article
protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat
Aplastic anemia (4,297 words) [view diff] exact match in snippet view article find links to article
colony formation of hematopoietic progenitor cells in vitro by inducing apoptosis of CD34+ cells of bone marrow. Short-lived aplastic anemia can also be
Isatuximab (3,034 words) [view diff] exact match in snippet view article find links to article
it can induce apoptosis without cross linking. Lastly, Isatuximab reveals direct killing activity when a larger increase in apoptosis is detected in
Isatuximab (3,034 words) [view diff] exact match in snippet view article find links to article
it can induce apoptosis without cross linking. Lastly, Isatuximab reveals direct killing activity when a larger increase in apoptosis is detected in
EIF2A (992 words) [view diff] exact match in snippet view article find links to article
alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis". The Journal of Biological Chemistry. 281 (30): 21458–68. doi:10.1074/jbc
SLC22A13 (449 words) [view diff] exact match in snippet view article find links to article
(2009). "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. doi:10.1038/cdd.2009.21.
DUSP16 (738 words) [view diff] exact match in snippet view article find links to article
expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate
Retinal nerve fiber layer (437 words) [view diff] exact match in snippet view article find links to article
RNFL is a sensitive structure. Some process can excites its natural apoptosis. Harmful situation can make some damage on RNFL such as high intraocular
Dihydroorotate dehydrogenase (1,525 words) [view diff] exact match in snippet view article find links to article
mitochondrial bioenergetics, cell proliferation, ROS production, and apoptosis in certain cell types. DHODH depletion also resulted in increased ROS
Scientific Research Publishing (925 words) [view diff] no match in snippet view article find links to article
Scientific Research Publishing (SCIRP) is an academic publisher of presumably peer-reviewed open-access electronic journals, conference proceedings, and
SERPINB9 (1,041 words) [view diff] exact match in snippet view article find links to article
coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM] Serpin GRCh38: Ensembl release
Envelope glycoprotein GP120 (2,504 words) [view diff] exact match in snippet view article find links to article
attachment to the host CD4 receptor. The HIV viral protein gp120 induces apoptosis of neuronal cells by inhibiting levels of furin and tissue plasminogen
Teplizumab (919 words) [view diff] exact match in snippet view article find links to article
complex associated with the development of anergy, unresponsiveness, and/or apoptosis, particularly of unwanted activated Teff cells. In addition, regulatory
Cutamesine (1,422 words) [view diff] exact match in snippet view article find links to article
These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological
Docetaxel (4,542 words) [view diff] exact match in snippet view article find links to article
inside the cell and cause initiation of apoptosis. Apoptosis is also encouraged by the blocking of apoptosis-blocking bcl-2 oncoprotein. Both in vitro
PTK2 (4,715 words) [view diff] exact match in snippet view article find links to article
FAT" and becomes the domain associated with death signaling. Throughout apoptosis, FAK is an important contributor to cell rounding, loss of focal contacts
P2RX3 (637 words) [view diff] exact match in snippet view article find links to article
bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of
BCL2L11 (1,355 words) [view diff] exact match in snippet view article find links to article
lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative
MOAP1 (606 words) [view diff] exact match in snippet view article find links to article
Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene. The protein encoded by this gene was identified by its interaction
Hopeaphenol (210 words) [view diff] exact match in snippet view article find links to article
wines from North Africa. It shows an opposite effect to vitisin A on apoptosis of myocytes isolated from adult rat heart. Phenolic compounds in wine
MAPK11 (1,209 words) [view diff] exact match in snippet view article find links to article
Russo T, Garaci E, Cozzolino F (2001). "Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2
UGCG (870 words) [view diff] exact match in snippet view article find links to article
functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–3865. ISSN 0008-5472
PLK3 (1,197 words) [view diff] exact match in snippet view article find links to article
(Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12
Adenovirus E1B protein (952 words) [view diff] exact match in snippet view article find links to article
These two proteins are needed to block apoptosis in adenovirus-infected cells. E1B proteins work to prevent apoptosis that is induced by the small adenovirus
Follicular dendritic cell sarcoma (2,537 words) [view diff] exact match in snippet view article find links to article
protein that aids in the clearance of cellular debris and is involved with apoptosis. Clusterin can be stained to help distinguish FDCS and is involved in
GDF15 (669 words) [view diff] exact match in snippet view article find links to article
in regulating inflammatory pathways and to be involved in regulating apoptosis, cell repair and cell growth, which are biological processes observed
GDF15 (669 words) [view diff] exact match in snippet view article find links to article
in regulating inflammatory pathways and to be involved in regulating apoptosis, cell repair and cell growth, which are biological processes observed
Photoaging (2,276 words) [view diff] exact match in snippet view article find links to article
apoptosis occurs if the damage is too severe. However, the apoptotic mechanisms decline with age, and if neither DNA repair mechanism nor apoptosis occurs
MAP3K14 (1,285 words) [view diff] exact match in snippet view article find links to article
target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042–7. Bibcode:1999PNAS...96
Mir-205 (2,654 words) [view diff] exact match in snippet view article find links to article
numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing
SOD2 (3,219 words) [view diff] exact match in snippet view article find links to article
this term was replaced by apoptosis to emphasize its role opposite mitosis in tissue kinetics. In later stages of apoptosis the entire cell becomes fragmented
PFKFB3 (3,708 words) [view diff] exact match in snippet view article find links to article
Pharmacological inhibition of PFKFB3 in vitro also protects neurons from apoptosis induced by NMDAR overexcitation as well as from amyloid-ß peptide-induced
Dynamin-like 120 kDa protein (1,924 words) [view diff] exact match in snippet view article find links to article
inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, and small, round mitochondria. Mutations in this gene have been implicated
Mir-153 microRNA precursor family (768 words) [view diff] exact match in snippet view article find links to article
Liang Y (March 2012). "miR-153 sensitized the K562 cells to As2O3-induced apoptosis". Medical Oncology. 29 (1): 243–7. doi:10.1007/s12032-010-9807-6. PMID 21267675
Stromatoxin (696 words) [view diff] exact match in snippet view article find links to article
in which the channels are expressed. Stromatoxin for example prohibits apoptosis in enterocytes (Grishin et al. 2005) and enhances myogenic constriction
Vitisin A (stilbenoid) (252 words) [view diff] exact match in snippet view article
(+)-epsilon-viniferin and ampelopsin B. It shows an opposite effect to hopeaphenol on apoptosis of myocytes isolated from adult rat heart. Poster at 1st International
Egg cell (1,440 words) [view diff] exact match in snippet view article find links to article
the oocytes. This transfer is followed by the programmed cell death (apoptosis) of the nurse cells. During oogenesis, 15 nurse cells die for every oocyte
Chrysophanol (1,423 words) [view diff] exact match in snippet view article find links to article
it can protect bronchial cells from cigarette smoke extract induced apoptosis. Chrysophanol can also improve the condition of renal interstitial fibrosis
ENDOG (2,404 words) [view diff] exact match in snippet view article find links to article
ENDOG gene. This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus
RNF34 (571 words) [view diff] exact match in snippet view article find links to article
a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic
ADAM15 (1,427 words) [view diff] exact match in snippet view article find links to article
is required for the activation of the FAK and Src pathways to generate apoptosis resistance in response to apoptotic signalling or cell stress. ADAM15
PMS2 (3,222 words) [view diff] exact match in snippet view article find links to article
counteracting p73-mediated apoptosis in a mismatch repair dependent manner. PMS2 can interact with p73 to enhance cisplatin-induced apoptosis by stabilizing p73
Vitisin A (stilbenoid) (252 words) [view diff] exact match in snippet view article
(+)-epsilon-viniferin and ampelopsin B. It shows an opposite effect to hopeaphenol on apoptosis of myocytes isolated from adult rat heart. Poster at 1st International
Egg cell (1,440 words) [view diff] exact match in snippet view article find links to article
the oocytes. This transfer is followed by the programmed cell death (apoptosis) of the nurse cells. During oogenesis, 15 nurse cells die for every oocyte
ADAM15 (1,427 words) [view diff] exact match in snippet view article find links to article
is required for the activation of the FAK and Src pathways to generate apoptosis resistance in response to apoptotic signalling or cell stress. ADAM15
Encephalocele (1,500 words) [view diff] exact match in snippet view article find links to article
ectoderm causes apoptosis in the midline. A disturbance in this separation process at the final closure due to the lack of apoptosis is considered to
ASK (116 words) [view diff] exact match in snippet view article find links to article
Latvian basketball club FK ASK, a Latvian former football club ASK1, apoptosis signal-regulating kinase 1 Aaru Sundarimaarude Katha, a 2013 Malayalam
COX-2 inhibitor (4,432 words) [view diff] exact match in snippet view article find links to article
enzyme has an adverse effect on the tumor suppressor, p53. p53 is an apoptosis transcription factor normally found in the cytosol. When cellular DNA
EGF-like domain (3,064 words) [view diff] no match in snippet view article find links to article
The EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described.
Plicamycin (493 words) [view diff] exact match in snippet view article find links to article
is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor. One elucidated pathway shows it interacts
Chemosterilant (772 words) [view diff] exact match in snippet view article find links to article
sterilization was being studied, known as apoptosis inducing agents. If cells are signaled to perform apoptosis rather than being eliminated by a foreign
Protein kinase N1 (1,755 words) [view diff] exact match in snippet view article find links to article
caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants