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searching for Ectodomain 166 found (209 total)

alternate case: ectodomain

Alpha secretase (950 words) [view diff] exact match in snippet view article find links to article

known as APPsα - into the extracellular environment in a process known as ectodomain shedding. ADAM10 consists of two protein domains, a disintegrin domain

Collagen, type XVII, alpha 1 (3,010 words) [view diff] exact match in snippet view article find links to article

form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form

CELSR2 (493 words) [view diff] exact match in snippet view article find links to article

growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to

CELSR3 (555 words) [view diff] exact match in snippet view article find links to article

growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to

Hepatitis C virus envelope glycoprotein E1 (879 words) [view diff] exact match in snippet view article find links to article

a type 1 transmembrane protein with a highly glycosylated N-terminal ectodomain and a C-terminal hydrophobic anchor. After being synthesized the E1 glycoproteins

Neuropilin (1,055 words) [view diff] exact match in snippet view article find links to article

also be found in soluble forms created by alternative splicing or by ectodomain shedding from the cell surface. The pleiotropic nature of the NRP receptors

TGF beta receptor 2 (960 words) [view diff] exact match in snippet view article find links to article

consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a

Growth hormone-binding protein (2,742 words) [view diff] exact match in snippet view article find links to article

is roughly 60 kDA in size. This cleaving process is called “receptor ectodomain shedding. In humans and rabbits, tumor-necrosis factor alpha converting

ADAM10 (2,465 words) [view diff] exact match in snippet view article find links to article

at the cellular surface. Once cleaved, the sheddases release soluble ectodomains with an altered location and function. Although a single sheddase may

Heparin-binding EGF-like growth factor (2,598 words) [view diff] exact match in snippet view article find links to article

87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences

SORL1 (1,660 words) [view diff] exact match in snippet view article find links to article

CNS. SORL1 is a multi domain single-pass membrane protein whose large ectodomain resides primarily in endosomal tubules, being connected by its transmembrane

Walter Fiers (726 words) [view diff] exact match in snippet view article find links to article

based on the M2 protein on the surface of the influenza A virus. The ectodomain of the M2 protein remains unchanged in all human influenza viruses known

FNDC5 (2,130 words) [view diff] exact match in snippet view article find links to article

comprising a short cytoplasmic domain, a transmembrane segment, and an ectodomain consisting of a ~100 kDa fibronectin type III (FNIII) domain. FNDC5 was

CD163 (2,166 words) [view diff] exact match in snippet view article find links to article

and cerebrospinal fluid., commonly denoted sCD163. It is generated by ectodomain shedding of the membrane bound receptor, which may represent a form of

Desmocollin (732 words) [view diff] exact match in snippet view article find links to article

Protein Data. "RCSB PDB - 5IRY: Crystal structure of human Desmocollin-1 ectodomain". www.rcsb.org. Retrieved 2020-04-25. Desmocollins at the U.S. National

Transferrin receptor 1 (937 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 1cx8: CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR 1de4: HEMOCHROMATOSIS PROTEIN HFE COMPLEXED WITH TRANSFERRIN RECEPTOR

Neprilysin (2,581 words) [view diff] exact match in snippet view article find links to article

Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported

FCGR2A (1,120 words) [view diff] case mismatch in snippet view article find links to article

ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA 1h9v: HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC 2fcb: HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)

L-selectin (2,808 words) [view diff] exact match in snippet view article find links to article

released through the process of ectodomain shedding and are replaced by newly synthesized L-selectin proteins. Ectodomain shedding is largely accomplished

Neuregulin (867 words) [view diff] exact match in snippet view article find links to article

NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds

ErbB (2,736 words) [view diff] exact match in snippet view article find links to article

are homologous to EGFR, but lack sequences within the ligand binding ectodomain. All four ErbB receptor family members are nearly same in the structure

TREM2 (4,092 words) [view diff] exact match in snippet view article find links to article

glycoproteins and lipids. This ectodomain component includes an Ig-like V-type domain, where ligands bind the receptor. The TREM2 ectodomain is modified after protein

IFNAR2 (1,400 words) [view diff] exact match in snippet view article find links to article

the interferon-binding ectodomain of the human interferon receptor 1n6v: Average structure of the interferon-binding ectodomain of the human type I interferon

Beta-secretase 2 (1,651 words) [view diff] exact match in snippet view article find links to article

BACE2 is the main protease that mediates the release of the amyloidogenic ectodomain of Pmel17 in melanocytes. BACE2 has also been observed in mice to be correlated

Glycoprotein Ib (263 words) [view diff] exact match in snippet view article find links to article

et al. (April 2023). "Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation". Journal of Thrombosis and Haemostasis. 21 (4): 995–1009

Immunoglobulin C2-set domain (611 words) [view diff] exact match in snippet view article find links to article

(ICAM) cell adhesion molecules. CD2 mediates T-cell adhesion via its ectodomain, and signal transduction utilising its 117-amino acid cytoplasmic tail

Betacellulin (1,786 words) [view diff] exact match in snippet view article find links to article

cell types and tissues, the post-translation of the betacellulin can ectodomain shedding, and the proteolytic release the soluble factors can bind and

BMPR1A (1,490 words) [view diff] exact match in snippet view article find links to article

Sebald W (February 2000). "Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2". FEBS Lett. 468 (2–3): 215–9. doi:10

PACSIN3 (651 words) [view diff] exact match in snippet view article find links to article

et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor"

Proteinase 3 (910 words) [view diff] exact match in snippet view article find links to article

humoral response neutrophil degranulation proteolysis membrane protein ectodomain proteolysis positive regulation of GTPase activity cell-cell junction

NRD1 (762 words) [view diff] exact match in snippet view article find links to article

PMID 16710414. Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor

GBA2 (942 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

FCGR2B (2,227 words) [view diff] case mismatch in snippet view article find links to article

ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA 1h9v: HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC 2fcb: HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)

Zinc transporter ZIP4 (146 words) [view diff] exact match in snippet view article find links to article

Kambe T, Andrews GK (January 2009). "Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited

Herpesvirus entry mediator (1,792 words) [view diff] exact match in snippet view article find links to article

diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor

Secretin receptor (907 words) [view diff] exact match in snippet view article find links to article

human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & Signal Transduction. 7 (3): 143–50. PMID 9440501

ADAM28 (603 words) [view diff] exact match in snippet view article find links to article

ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23". J. Biol. Chem. 278 (33): 30469–30477. doi:10.1074/jbc

ADAM19 (1,001 words) [view diff] exact match in snippet view article find links to article

extracellular matrix Biological process heart development membrane protein ectodomain proteolysis proteolysis extracellular matrix organization placenta development

NCR1 (978 words) [view diff] exact match in snippet view article find links to article

et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. doi:10.1016/j.bbrc.2003

TGFBR3 (1,632 words) [view diff] exact match in snippet view article find links to article

and other enzymes present in the ECM. Proteolytic cleavage releases an ectodomain containing two binding sites for TGF-beta. Due to high affinity to its

ADAM8 (617 words) [view diff] exact match in snippet view article find links to article

involved in inflammatory response positive regulation of membrane protein ectodomain proteolysis positive regulation of protein kinase B signaling positive

Stem cell factor (2,954 words) [view diff] exact match in snippet view article find links to article

839068. PMID 19738140. Lev S, Yarden Y, Givol D (May 1992). "A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced

Toll-like receptor (6,771 words) [view diff] exact match in snippet view article find links to article

directly by pathogen-associated molecular patterns (PAMPs). Its receptor ectodomain recognizes the cleaved form of the cytokine spätzle, which is secreted

Frizzled-7 (795 words) [view diff] exact match in snippet view article find links to article

PMID 15489334. Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and

Nipah virus (4,179 words) [view diff] exact match in snippet view article find links to article

C, V and W. There are two envelope glycoproteins. The G glycoprotein ectodomain assembles as a homotetramer to form the viral anti-receptor or attachment

Relaxin/insulin-like family peptide receptor 2 (791 words) [view diff] exact match in snippet view article find links to article

ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc

Presenilin-2 (1,100 words) [view diff] exact match in snippet view article find links to article

apoptotic process amyloid-beta metabolic process proteolysis membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis positive

CD32 (1,163 words) [view diff] exact match in snippet view article find links to article

receptor (CD32) Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32). Identifiers Symbol FCGR2B Alt. symbols FCG2, FCGR2 NCBI gene 2213

DDR1 (1,207 words) [view diff] exact match in snippet view article find links to article

tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene. 9 (1): 211–9. PMID 8302582. Johnson JD, Edman JC, Rutter WJ

PTPN3 (895 words) [view diff] exact match in snippet view article find links to article

transmembrane transporter activity negative regulation of membrane protein ectodomain proteolysis negative regulation of mitotic cell cycle dephosphorylation

ADAM12 (1,579 words) [view diff] exact match in snippet view article find links to article

Matsuura N (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor"

Alpha-2A adrenergic receptor (1,303 words) [view diff] exact match in snippet view article find links to article

regulation of norepinephrine secretion positive regulation of membrane protein ectodomain proteolysis negative regulation of insulin secretion involved in cellular

Toll-like receptor 3 (1,027 words) [view diff] exact match in snippet view article find links to article

(July 2005). "Crystal structure of human toll-like receptor 3 (TLR3) ectodomain". Science. 309 (5734): 581–585. Bibcode:2005Sci...309..581C. doi:10.1126/science

Relaxin/insulin-like family peptide receptor 1 (1,241 words) [view diff] exact match in snippet view article find links to article

ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". The Journal of Biological Chemistry. 278 (10): 7855–62

Viral protein (1,673 words) [view diff] exact match in snippet view article find links to article

central coiled-coil structure. Contains a characteristic elongated β- sheet ectodomain structure that refolds to give a trimer of hairpins. Examples of class

Kinetic-segregation model of T cell activation (1,195 words) [view diff] exact match in snippet view article find links to article

TCR/peptide-MHC complex. Phosphatases CD45 and CD148 with much larger ectodomains than TCR are sterically excluded from the close contact zones, while

KIT (gene) (4,117 words) [view diff] exact match in snippet view article

12129. PMID 8647802. Lev S, Yarden Y, Givol D (May 1992). "A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced

Poliovirus receptor-related 1 (1,379 words) [view diff] exact match in snippet view article find links to article

Cocchi F, Menotti L, Mirandola P, Lopez M, Campadelli-Fiume G (1998). "The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus

Collagen, type XIII, alpha 1 (893 words) [view diff] exact match in snippet view article find links to article

PMID 10865988. Tu H, Sasaki T, Snellman A, et al. (2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan

P2RX3 (642 words) [view diff] exact match in snippet view article find links to article

(2005). "Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory

Ephrin B2 (1,320 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 1iko: CRYSTAL STRUCTURE OF THE MURINE EPHRIN-B2 ECTODOMAIN 1kgy: Crystal Structure of the EphB2-ephrinB2 complex 2hle: Structural and

CORIN (2,017 words) [view diff] exact match in snippet view article find links to article

N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding". The Journal of Biological Chemistry. 290 (3): 1654–1663. doi:10

P2RX7 (3,366 words) [view diff] exact match in snippet view article find links to article

Jindrichova M, Kuzyk P, Li S, Stojilkovic SS, Zemkova H (June 2012). "Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking". Purinergic

CADASIL (1,899 words) [view diff] exact match in snippet view article find links to article

PMID 25824603. Joutel A, Andreux F, Gaulis S, et al. (March 2000). "The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL

NOTCH3 (1,369 words) [view diff] exact match in snippet view article find links to article

Battail N, Piga N, Chapon F, Godfrain C, Tournier-Lasserve E (2000). "The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL

Tumor necrosis factor receptor 2 (1,387 words) [view diff] exact match in snippet view article find links to article

response to growth factor stimulus positive regulation of membrane protein ectodomain proteolysis ageing multicellular organism development cell surface receptor

Dystroglycan (1,615 words) [view diff] exact match in snippet view article find links to article

regulation of cell migration Schwann cell development membrane protein ectodomain proteolysis calcium-dependent cell-matrix adhesion negative regulation

Follicle-stimulating hormone (2,261 words) [view diff] exact match in snippet view article find links to article

"Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor". Proceedings of the National Academy of Sciences of the

Pleiotrophin (1,649 words) [view diff] exact match in snippet view article find links to article

mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region". J. Biol. Chem. 270 (44): 26404–10. doi:10.1074/jbc.270

Enfuvirtide (820 words) [view diff] exact match in snippet view article find links to article

Gao JL, Shen WP, Grimm MC, Deng X, et al. (June 1999). "T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of

Relaxin (2,405 words) [view diff] exact match in snippet view article find links to article

contain a heptahelical transmembrane domain and a large glycosylated ectodomain, distantly related to the receptors for the glycoproteohormones, such

Nidogen-2 (602 words) [view diff] exact match in snippet view article find links to article

Pirilä P, Timpl R, Pihlajaniemi T (Jun 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan

Nicastrin (901 words) [view diff] exact match in snippet view article find links to article

cell proliferation proteolysis T cell proliferation membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis positive

Bone morphogenetic protein 2 (1,374 words) [view diff] exact match in snippet view article find links to article

Sebald W (February 2000). "Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2". FEBS Lett. 468 (2–3): 215–9. Bibcode:2000FEBSL

Nidogen-2 (602 words) [view diff] exact match in snippet view article find links to article

Pirilä P, Timpl R, Pihlajaniemi T (Jun 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan

LINGO1 (4,882 words) [view diff] exact match in snippet view article find links to article

Pangalos MN, Walsh FS, Somers WS (Nov 2006). "The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition". The

CALCRL (1,701 words) [view diff] exact match in snippet view article find links to article

Garcia-Guzman M, Moore JM (September 2010). "Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug

Relaxin (2,405 words) [view diff] exact match in snippet view article find links to article

contain a heptahelical transmembrane domain and a large glycosylated ectodomain, distantly related to the receptors for the glycoproteohormones, such

Collagen, type XXIII, alpha 1 (1,559 words) [view diff] exact match in snippet view article find links to article

of two forms of the molecule: a full-length membrane-bound form and an ectodomain shed form. This characteristic can be also applicable to collagen XXIII

Follicle-stimulating hormone receptor (1,722 words) [view diff] exact match in snippet view article find links to article

"Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor". Proceedings of the National Academy of Sciences of the

Protocadherin (1,810 words) [view diff] exact match in snippet view article find links to article

Ludwig A, Frank M, Saftig P (August 2006). "Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion". The

MAN1A2 (842 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–160. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

Tetherin (2,458 words) [view diff] exact match in snippet view article find links to article

transmembrane of tetherin is predicted to be a single alpha helix. The ectodomain consists of alpha helical coiled-coil region where the coils are slightly

ROCK1 (2,136 words) [view diff] exact match in snippet view article find links to article

regulation of neuron differentiation negative regulation of membrane protein ectodomain proteolysis negative regulation of biomineral tissue development response

Angiotensin-converting enzyme 2 (5,225 words) [view diff] exact match in snippet view article find links to article

2005). "Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV)

Syndecan 1 (2,522 words) [view diff] exact match in snippet view article find links to article

K, Bernfield M (October 2004). "Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1". The Journal of

SPPL2A (715 words) [view diff] exact match in snippet view article find links to article

Biological process membrane protein proteolysis proteolysis membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis regulation

Env (gene) (2,253 words) [view diff] exact match in snippet view article

GM (August 1998). "Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41". EMBO J. 17 (16): 4572–84. doi:10.1093/emboj/17.16.4572.

Anne Joutel (778 words) [view diff] exact match in snippet view article find links to article

S Gaulis, V Domenga, M Cecillon, N Battail, N Piga, et al. 2000. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL

TIMP3 (999 words) [view diff] exact match in snippet view article find links to article

regulation of ERK1 and ERK2 cascade negative regulation of membrane protein ectodomain proteolysis visual perception platelet degranulation response to organic

GCS1 (996 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

RBMX (1,026 words) [view diff] exact match in snippet view article find links to article

negative regulation of mRNA splicing, via spliceosome membrane protein ectodomain proteolysis osteoblast differentiation cellular response to interleukin-1

PRKCQ (2,407 words) [view diff] exact match in snippet view article find links to article

signaling pathway positive regulation of T cell activation membrane protein ectodomain proteolysis positive regulation of NF-kappaB transcription factor activity

Julia Gog (1,250 words) [view diff] exact match in snippet view article find links to article

of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain". PLOS Pathogens. 8 (11): e1002998. doi:10.1371/journal.ppat.1002998.

PEN-2 (406 words) [view diff] exact match in snippet view article find links to article

processing positive regulation of catalytic activity membrane protein ectodomain proteolysis Notch receptor processing amyloid precursor protein catabolic

Transforming growth factor, beta 3 (1,815 words) [view diff] exact match in snippet view article find links to article

Hinck CS, Hinck AP (Mar 2002). "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex". Nature Structural Biology. 9 (3): 203–8. doi:10.1038/nsb766

MANEA (839 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347

Collagen receptor (1,090 words) [view diff] exact match in snippet view article find links to article

level of expression is high in adults as well. DDR1 is a homodimer. Its ectodomain consists of a collagen-binding discoidin domain followed by ~200 residues

Cadherin (3,594 words) [view diff] exact match in snippet view article find links to article

Ribbon representation of a repeating unit in the extracellular E-cadherin ectodomain of the mouse (PDB: 3Q2V) Identifiers Symbol Cadherin Pfam PF00028 InterPro

Pertuzumab (2,276 words) [view diff] exact match in snippet view article find links to article

anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells" (PDF). Cancer Research. 61 (12): 4744–4749

Ephrin (2,476 words) [view diff] exact match in snippet view article find links to article

doi:10.1038/nn1237. PMID 15107857. S2CID 15643420. Himanen JP (Feb 2012). "Ectodomain structures of Eph receptors". Seminars in Cell & Developmental Biology

SNX9 (1,009 words) [view diff] exact match in snippet view article find links to article

formation mitotic cytokinesis positive regulation of membrane protein ectodomain proteolysis receptor-mediated endocytosis plasma membrane tubulation cell

Interferon-alpha/beta receptor (2,617 words) [view diff] exact match in snippet view article find links to article

(alpha, beta and omega) receptor 2 NMR structure of the interferon-binding ectodomain of the human interferon receptor. Identifiers Symbol IFNAR2 Alt. symbols

Alphavirus (3,384 words) [view diff] exact match in snippet view article find links to article

interact with the nucleocapsid through its cytoplasmic domain, while its ectodomain is responsible for binding a cellular receptor. Most alphaviruses lose

Furin (2,288 words) [view diff] exact match in snippet view article find links to article

biosynthetic process protein processing positive regulation of membrane protein ectodomain proteolysis extracellular matrix disassembly extracellular matrix organization

MAN2B2 (1,009 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

MEP1B (913 words) [view diff] exact match in snippet view article find links to article

Roesmann S, et al. (2003). "Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease"

MAN1B1 (942 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

Beta-secretase 1 (1,955 words) [view diff] exact match in snippet view article find links to article

catabolic process proteolysis amyloid-beta metabolic process membrane protein ectodomain proteolysis modulation of chemical synaptic transmission response to radiation

Fibroblast growth factor receptor 2 (1,745 words) [view diff] exact match in snippet view article find links to article

TL (Oct 2000). "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin". Nature. 407 (6807): 1029–34. Bibcode:2000Natur

CDH23 (1,364 words) [view diff] exact match in snippet view article find links to article

containing 27 repeats that show significant homology to the cadherin ectodomain. Expressed in the neurosensory epithelium, the protein is thought to be

Presenilin (2,110 words) [view diff] exact match in snippet view article find links to article

relatively small extracellular regions. These substrates arise following ectodomain shedding. Well over 100 different integral membrane proteins are processed

Syncytin-1 (2,024 words) [view diff] exact match in snippet view article find links to article

indicate this motif contains the ASCT2 binding determinants. The largest ectodomain of ASCT1 and ASCT2, extracellular loop 2 (ECL2), contains at its C-terminus

MGAT5B (920 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

Amphiregulin (3,296 words) [view diff] exact match in snippet view article find links to article

Endo T, Nakagawa T, Miyagawa JI, Yamamori K, et al. (October 2000). "Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte

RNF43 (801 words) [view diff] exact match in snippet view article find links to article

predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively

UNQ1887 (509 words) [view diff] exact match in snippet view article find links to article

regulation of cytosolic calcium ion concentration proteolysis membrane protein ectodomain proteolysis positive regulation of protein binding T cell receptor signaling

GPLD1 (984 words) [view diff] exact match in snippet view article find links to article

cell migration to bone marrow positive regulation of membrane protein ectodomain proteolysis positive regulation of glucose metabolic process hematopoietic

MAN2A1 (1,164 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". Journal of Virology. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993

SPPL2B (733 words) [view diff] exact match in snippet view article find links to article

Biological process membrane protein proteolysis proteolysis membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis regulation

UNQ1887 (509 words) [view diff] exact match in snippet view article find links to article

regulation of cytosolic calcium ion concentration proteolysis membrane protein ectodomain proteolysis positive regulation of protein binding T cell receptor signaling

GPLD1 (984 words) [view diff] exact match in snippet view article find links to article

cell migration to bone marrow positive regulation of membrane protein ectodomain proteolysis positive regulation of glucose metabolic process hematopoietic

Β-Mannosidase (1,171 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

Plexin (1,611 words) [view diff] exact match in snippet view article find links to article

Iwasaki K, Hattori K, Takagi J (June 2016). "Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies". PLOS ONE. 11 (6): e0156719

MMP2 (2,812 words) [view diff] exact match in snippet view article find links to article

interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not

PCDHGC3 (723 words) [view diff] exact match in snippet view article find links to article

region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common

Rhomboid-related protein 2 (563 words) [view diff] exact match in snippet view article find links to article

Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018). "Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent

Interleukin 1 beta (3,273 words) [view diff] exact match in snippet view article find links to article

nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of interferon-gamma production MAPK cascade

FXYD5 (1,216 words) [view diff] exact match in snippet view article find links to article

Vazquez-Levin M, Sznajder JI, Vagin O, Dada LA (June 2016). "The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of

Gisou van der Goot (1,233 words) [view diff] exact match in snippet view article find links to article

Andrea (2011). "Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors".

HM13 (1,137 words) [view diff] exact match in snippet view article find links to article

cytosol membrane protein intracellular domain proteolysis membrane protein ectodomain proteolysis protein homotetramerization signal peptide processing Sources:Amigo

Fibroblast growth factor 1 (2,311 words) [view diff] exact match in snippet view article find links to article

(October 2000). "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin". Nature. 407 (6807): 1029–34. Bibcode:2000Natur

TIMP1 (1,179 words) [view diff] exact match in snippet view article find links to article

proliferation response to hormone negative regulation of membrane protein ectodomain proteolysis negative regulation of endopeptidase activity negative regulation

Presenilin-1 (3,113 words) [view diff] exact match in snippet view article find links to article

damage stimulus heart looping blood vessel development membrane protein ectodomain proteolysis regulation of epidermal growth factor-activated receptor activity

MAN1A1 (985 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347

Cyclin H (1,468 words) [view diff] exact match in snippet view article find links to article

tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene. 9 (1): 211–9. PMID 8302582. Tassan JP, Jaquenoud M, Fry AM

Laron syndrome (2,885 words) [view diff] exact match in snippet view article find links to article

receptor (GHR). These can result in defective hormone binding to the ectodomain or reduced efficiency of dimerization of the receptor after hormone occupancy

Interleukin 10 (4,619 words) [view diff] exact match in snippet view article find links to article

tumor necrosis factor production negative regulation of membrane protein ectodomain proteolysis inflammatory response cellular response to lipopolysaccharide

LU domain (740 words) [view diff] exact match in snippet view article find links to article

Sebald W, Dreyer MK (June 2000). "Crystal structure of the BMP-2-BRIA ectodomain complex". Nature Structural Biology. 7 (6): 492–6. doi:10.1038/75903.

Ephrin receptor (3,454 words) [view diff] exact match in snippet view article find links to article

1038/nn1237. PMID 15107857. S2CID 15643420. Himanen JP (February 2012). "Ectodomain structures of Eph receptors". Semin. Cell Dev. Biol. 23 (1): 35–42. doi:10

Cytotrienin A (736 words) [view diff] exact match in snippet view article find links to article

Takao (2011-09-30). "Cytotrienin A, a translation inhibitor that induces ectodomain shedding of TNF receptor 1 via activation of ERK and p38 MAP kinase".

Tumor necrosis factor (6,233 words) [view diff] exact match in snippet view article find links to article

regulation of interleukin-6 production positive regulation of membrane protein ectodomain proteolysis positive regulation of humoral immune response mediated by

Phlebovirus (2,895 words) [view diff] exact match in snippet view article find links to article

with respect to the viral membrane. This is known because the RVFV Gc ectodomain is crystallized as a dimer. This is opposed to the virion interior of

MGAT4B (1,012 words) [view diff] exact match in snippet view article find links to article

human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347

Dengue virus (7,196 words) [view diff] exact match in snippet view article find links to article

this particle to the host cell. Each E protein monomer comprises three ectodomains, ED1 to ED3, and a transmembrane segment. ED2 includes the dimerization

Cadherin-1 (6,380 words) [view diff] exact match in snippet view article find links to article

cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the

ABO blood group system (5,995 words) [view diff] exact match in snippet view article find links to article

A. (April 2023). "Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation". Journal of Thrombosis and Haemostasis. 21 (4): 995–1009

Beta bend ribbon (722 words) [view diff] exact match in snippet view article find links to article

K, Tessier-Lavigne M, He Z, Garcia KC. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron 2003; 38:177–185

Trastuzumab (6,103 words) [view diff] exact match in snippet view article find links to article

also known as CDKN1B. Trastuzumab has been shown to inhibit HER2/neu ectodomain cleavage in breast cancer cells. Experiments in laboratory animals indicate

Three-finger protein (1,437 words) [view diff] exact match in snippet view article find links to article

Sebald W, Dreyer MK (June 2000). "Crystal structure of the BMP-2-BRIA ectodomain complex". Nature Structural Biology. 7 (6): 492–6. doi:10.1038/75903.

Reticulon 4 receptor (1,577 words) [view diff] exact match in snippet view article find links to article

Bazan JF, McDermott G, et al. (2003). "Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition". Neuron. 38 (2):

Apolipoprotein E (6,407 words) [view diff] exact match in snippet view article find links to article

regulation of amyloid-beta formation positive regulation of membrane protein ectodomain proteolysis vasodilation intracellular transport synaptic transmission

Interferon gamma (6,483 words) [view diff] exact match in snippet view article find links to article

cholinergic response to virus positive regulation of membrane protein ectodomain proteolysis positive regulation of epithelial cell migration positive

Nickel allergy (3,598 words) [view diff] exact match in snippet view article find links to article

(December 2017). "Ni(II) interaction with a peptide model of the human TLR4 ectodomain". Journal of Trace Elements in Medicine and Biology. 44: 151–160. doi:10

PTPRK (4,376 words) [view diff] exact match in snippet view article find links to article

GnT-V in these cells increased the cleavage and shedding of PTPkappa ectodomain and increased migration of WiDr cells in transwell assays. As a result

ANTXR2 (1,282 words) [view diff] exact match in snippet view article find links to article

Gisou van der Goot F (2009). "Systemic Hyalinosis Mutations in the CMG2 Ectodomain Leading to Loss of Function Through Retention in the Endoplasmic Reticulum"

TREM1 (2,762 words) [view diff] exact match in snippet view article find links to article

Vallejo-Cremades MT, et al. (September 2007). "Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes". Journal of Immunology

Gabriella Campadelli-Fiume (1,624 words) [view diff] exact match in snippet view article find links to article

tumor]". Actas Urol Esp (in Spanish). 16 (9): 736–8. PMID 1488928. The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane α-Helix with

Reticulon 4 (1,924 words) [view diff] exact match in snippet view article find links to article

(Aug 2007). "Nogo-B receptor possesses an intrinsically unstructured ectodomain and a partially folded cytoplasmic domain". Biochemical and Biophysical

MYH9 (6,349 words) [view diff] exact match in snippet view article find links to article

migration establishment of T cell polarity myoblast fusion membrane protein ectodomain proteolysis actomyosin structure organization angiogenesis integrin-mediated

Jue Chen (scientist) (1,717 words) [view diff] exact match in snippet view article

N-Terminal Fusion Peptide Solubilizes the Influenza Virus HA2Subunit Ectodomain†". Biochemistry. 37 (39): 13643–13649. doi:10.1021/bi981098l. ISSN 0006-2960

CAR T cell (8,682 words) [view diff] exact match in snippet view article find links to article

antigen recognition domain is exposed to the outside of the cell, in the ectodomain portion of the receptor. It interacts with potential target molecules

Telokin (2,505 words) [view diff] exact match in snippet view article find links to article

was invented. These kind of domains mediates T-cell adhesion via its ectodomain, and signal transduction.[2] KRP presence in different tissues has been

Modoc virus (2,111 words) [view diff] exact match in snippet view article find links to article

of virus particle replication organelles. The NS1 protein has a large ectodomain which is believed to function in the deformation of the ER membrane from

Nicotinic acid adenine dinucleotide phosphate (6,140 words) [view diff] exact match in snippet view article find links to article

NAADP (and cADPR) in humans both have their active synthesis site in the ectodomain. Though this may involve vesicular synthesis but it has been shown that

ERAP1 (3,819 words) [view diff] exact match in snippet view article find links to article

class I proteolysis positive regulation of angiogenesis membrane protein ectodomain proteolysis angiogenesis fat cell differentiation peptide catabolic process