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searching for Presenilin-2 23 found (32 total)

Presenilin (2,110 words) [view diff] no match in snippet view article find links to article

presenilin 1 (PS-1) and PSEN2 (on chromosome 1 in humans) that codes for presenilin 2 (PS-2). Both genes show conservation between species, with little difference

Calsenilin (1,332 words) [view diff] no match in snippet view article find links to article

with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424

Caspase 6 (1,632 words) [view diff] exact match in snippet view article find links to article

J, Schindzielorz A, Grünberg J, Haass C (1999). "Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis"

KCNIP4 (704 words) [view diff] no match in snippet view article find links to article

characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem. 277 (17):

Calpain-1 catalytic subunit (1,077 words) [view diff] no match in snippet view article find links to article

Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K (1998). "The presenilin 2 loop domain interacts with the mu-calpain C-terminal region". Int. J

Genetic heterogeneity (1,248 words) [view diff] no match in snippet view article find links to article

encode the amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) that cause the autosomal dominant, early-onset form of familial

KCND2 (1,213 words) [view diff] no match in snippet view article find links to article

characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J. Biol. Chem. 277

CIB1 (2,206 words) [view diff] no match in snippet view article find links to article

calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. Cell Biol. 145 (6): 1277–92. doi:10.1083/jcb.145.6.1277

Chromosome 1 (3,290 words) [view diff] no match in snippet view article find links to article

oxidase PRCC (1q23) PRR9 encoding protein Proline rich 9 PSEN2 (1q42): presenilin 2 (Alzheimer disease 4) PTGS2 (1q31) PTPN14 (1q32-41) PTPN7 (1q32) RABIF:

SFRS2IP (487 words) [view diff] exact match in snippet view article find links to article

et al. (1999). "Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1

Kv channel interacting protein (503 words) [view diff] no match in snippet view article find links to article

characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem. 277 (17):

SRI (gene) (1,046 words) [view diff] no match in snippet view article

Pettingell WP, Moir RD, Brownawell AM, Cheng I, Tanzi RE, Kim TW (May 2000). "Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor". The Journal

Notch signaling pathway (11,025 words) [view diff] exact match in snippet view article find links to article

layers during early skin development. Furthermore, it has found that presenilin-2 works in conjunction with ARF4 to regulate Notch signaling during this

Bcl-2-like protein 1 (2,223 words) [view diff] exact match in snippet view article find links to article

D'Adamio L (Aug 1999). "Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death"

P3 peptide (1,340 words) [view diff] no match in snippet view article find links to article

"Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin 1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of

CREB-binding protein (5,272 words) [view diff] no match in snippet view article find links to article

activity is decreased in the absence of these proteins (presenilin 1 or presenilin 2). Additionally, in mouse models of AD, it has been shown that there is

MFN2 (3,346 words) [view diff] no match in snippet view article find links to article

"Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2". Aging Cell. 11 (5): 885–93. doi:10.1111/j.1474-9726.2012.00858.x. hdl:10261/112103

Alzheimer's disease in the Hispanic/Latino population (6,438 words) [view diff] exact match in snippet view article find links to article

familial AD are amyloid precursor protein (APP), Presenilin-1 (PSEN-1), presenilin-2 (PSEN-2). Onset of sporadic AD has both genetic and environmental risk

Rudolph E. Tanzi (4,371 words) [view diff] no match in snippet view article find links to article

neurotoxicity. 1995: Cloned and discovered first mutations in AD gene presenilin 2; collaborated on the cloning of presenilin 1. 1999: Mapped the BACE2

APH-1 (2,524 words) [view diff] no match in snippet view article find links to article

PMID 21335653. Meckler X, Checler F (June 2016). "Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments". The

CRISPR gene editing (19,892 words) [view diff] no match in snippet view article find links to article

specifically amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2). Over 300 mutations have been detected in these genes, resulting

Alzheimer's disease in African Americans (4,470 words) [view diff] no match in snippet view article find links to article

beta 40 ratio is a sign of disease progression. Presenilin 1 (PS1) and Presenilin 2 (PS2) are the cleaving enzymes in the γ-secretase complex. There are

Nicolas Bazan (4,359 words) [view diff] exact match in snippet view article find links to article

43:3511-3521, 2002 Lukiw WJ, Gordon WC, Rogaev EI, Thompson H, Bazan NG: Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity