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Longer titles found: Engineered CAR T cell delivery (view)

searching for CAR T cell 92 found (118 total)

alternate case: cAR T cell

Axicabtagene ciloleucel (1,361 words) [view diff] no match in snippet view article find links to article

Machine Med Lett Drugs Ther. 2018 Jul 16;60(1551):e122-123 "FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma".

Molecular oncology (1,081 words) [view diff] no match in snippet view article find links to article

receptors on the CAR-T cell; through manipulation of these receptors and the molecules that bind them, expression of the CAR-T cell can be amplified.

Malaghan Institute of Medical Research (514 words) [view diff] no match in snippet view article find links to article

began New Zealand's first clinical trial of CAR T-cell therapy, trialling a third-generation CAR T-cell therapy in partnership with Wellington Zhaotai

Leukapheresis (637 words) [view diff] no match in snippet view article find links to article

its use is controversial and rare. Leukapheresis is used in evolving CAR-T cell therapy to obtain leukocytes from a cancer patient or donor which can

Cytokine release syndrome (2,551 words) [view diff] no match in snippet view article find links to article

transfer of autologous T-cells modified with chimeric antigen receptors (CAR-T cell therapy) also causes CRS. Serum samples of patients with CAR-T associated

CancerVax (1,529 words) [view diff] no match in snippet view article find links to article

expressed by the cancer cells. Canvaxin is an example of this therapy. -CAR-T cell therapy: In 2023, the company partnered with research team from the University

Idecabtagene vicleucel (1,009 words) [view diff] no match in snippet view article find links to article

(BCMA)-directed genetically modified autologous chimeric antigen receptor (CAR) T-cell therapy. Each dose is customized using a patient's own T-cells, which

Cancer immunotherapy (12,358 words) [view diff] no match in snippet view article find links to article

for prostate cancer) has been approved. In cell-mediated therapies like CAR-T cell therapy, immune cells are extracted from the patient, genetically engineered

Lisocabtagene maraleucel (1,645 words) [view diff] no match in snippet view article find links to article

constipation, and fever. Lisocabtagene maraleucel, a chimeric antigen receptor (CAR) T cell (CAR-T) therapy, is the third gene therapy approved by the US Food and

Ciltacabtagene autoleucel (1,041 words) [view diff] no match in snippet view article find links to article

antigen)-directed genetically modified autologous chimeric antigen receptor (CAR) T-cell therapy. Each dose is customized using the recipient's own T-cells, which

Brexucabtagene autoleucel (1,248 words) [view diff] no match in snippet view article find links to article

brexucabtagene autoleucel, a CD19-directed chimeric antigen receptor (CAR) T-cell therapy. Participants received a single infusion of brexucabtagene autoleucel

Loncastuximab tesirine (989 words) [view diff] no match in snippet view article find links to article

action, loncastuximab tesirine may be appealing in patients ineligible for CAR-T cell therapy. "Zynlonta- loncastuximab tesirine injection, powder, lyophilized

Donald O'Rourke (267 words) [view diff] no match in snippet view article find links to article

especially the design and investigation of chimeric antigen receptor (CAR T-cell) immune therapies. As principal investigator, O'Rourke led the first-in-human

Timeline of immunology (2,182 words) [view diff] no match in snippet view article find links to article

– First autologous CAR T-cell therapy tisagenlecleucel approved for the treatment of pediatric B-ALL; second autologous CAR T-cell therapy axicabtagene

SIGLEC6 (2,036 words) [view diff] exact match in snippet view article find links to article

and acute myeloid leukemia cells and is being explored as a target of CAR T cell therapy. Siglec-6 was identified in a screen for leptin-binding proteins

Stephan Grupp (1,414 words) [view diff] no match in snippet view article find links to article

the first highly effective childhood cancer immunotherapy and delivered CAR T-cell therapy to the first pediatric patient in the world. Grupp was born to

Precision BioSciences (1,642 words) [view diff] no match in snippet view article find links to article

Sciences to explore using foralumab to aid chimeric antigen receptor (CAR) T cell therapy, and with Philadelphia-based iECURE to advance candidates into

Misty Jenkins (1,249 words) [view diff] no match in snippet view article find links to article

Specifically, Jenkins' research group uses using chimeric antigen receptor (CAR) T cell therapy, a new form of immune-targeted therapy that trains the body's

Memorial Sloan Kettering Cancer Center (3,678 words) [view diff] no match in snippet view article find links to article

"Sloan-Kettering Receives $50 Million From Robertson Foundation". "FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma".

Virotherapy (3,501 words) [view diff] exact match in snippet view article find links to article

Chimeric antigen receptor T cell (CAR T cell) are a type of immunotherapy that makes use of viral gene editing. CAR T cell use an ex vivo method in which

B-cell maturation antigen (1,937 words) [view diff] no match in snippet view article find links to article

preclinical and phase I clinical studies. A Phase 1b/2 study of JNJ-4528, a CAR-T cell therapy directed against BCMA in myeloma patients refractory to a proteasome

Cellular adoptive immunotherapy (2,170 words) [view diff] exact match in snippet view article find links to article

treating solid tumors than other cellular adoptive immunotherapies such as CAR T cell therapy. Chimeric antigen receptor T-cells (CAR-T) are predominantly used

Todd M. Allen (854 words) [view diff] no match in snippet view article find links to article

towards a functional cure of HIV, including chimeric antigen receptor (CAR) T cell immunotherapy and gene editing approaches capable of protecting against

Crystal Mackall (2,787 words) [view diff] no match in snippet view article find links to article

Distinguished Lectureship 2018 Top 10 Clinical Research Award for New CAR-T Cell Therapy for Relapsed Leukemia 2019 American Academy of Dermatology Lila

Michel Sadelain (2,452 words) [view diff] exact match in snippet view article find links to article

target for CAR therapy in mice. Following the establishment of clinical CAR T cell manufacturing by Dr. Isabelle Rivière at MSK, Sadelain's team was the

Bluebird bio (1,409 words) [view diff] no match in snippet view article find links to article

announced a collaboration with bluebird bio regarding bb2121 Anti-BCMA CAR-T Cell Therapy. In May 2020, the Food and Drug Administration (FDA) issued a

COH04S1 (550 words) [view diff] exact match in snippet view article find links to article

accepted blood cancer patients who received a bone marrow transplant, or a CAR T cell therapy at least three months before volunteering, as well as meeting

Juno Therapeutics (828 words) [view diff] no match in snippet view article find links to article

signed an agreement with Opus Bio, Inc for a chimeric antigen receptor (CAR-T) cell product candidate targeting CD22. In April 2015 the company entered into

Zelig Eshhar (395 words) [view diff] no match in snippet view article find links to article

Retrieved 19 September 2014.[dead link] Brower, Vicki (April 1, 2015). "The CAR T-Cell Race". The Scientist. "Awards". www.esgct. Retrieved 12 December 2017

Immunopathology (1,245 words) [view diff] no match in snippet view article find links to article

inhibitors, which block molecules that inhibit T cell activation, and CAR-T cell therapy, which involves modifying T cells to recognize and attack cancer

Fuda Cancer Hospital-Guangzhou (973 words) [view diff] no match in snippet view article find links to article

intervention (CMI), combined immunotherapy for cancer (CIC including NK and CAR-T cell immunotherapy), and personalized treatment which both prolongs and improves

Diffuse large B-cell lymphoma (8,143 words) [view diff] no match in snippet view article find links to article

the cytokine release syndrome (21% of cases), neurotoxicity, i.e. the CAR-T cell-related encephalopathy syndrome (9% of cases), and the hemophagocytic

Autotransplantation (1,261 words) [view diff] no match in snippet view article find links to article

Is There Still a Role for Autologous Stem Cell Transplantation in the CAR T-Cell Era?". Cancers (Basel). 16 (11). doi:10.3390/cancers16111987. PMC 11171011

Prescient Therapeutics (2,313 words) [view diff] no match in snippet view article find links to article

on the development of a universal CAR-T platform (OmniCAR), enhanced CAR-T cell manufacturing & function (CellPryme) and on two small molecule drug targeted

Certificate of need (1,556 words) [view diff] no match in snippet view article find links to article

restrict the availability of CAR T-cell cancer therapy to only the largest (predominantly urban) hospitals by classifying CAR T-cell therapy a "new" provision

Nirali N. Shah (1,198 words) [view diff] no match in snippet view article find links to article

trials focus on exploring and optimizing chimeric antigen receptor T cell (CAR-T cell) based strategies and other antibody based therapies to target surface

Antigenic escape (1,583 words) [view diff] no match in snippet view article find links to article

antigens, as well demonstrated after checkpoint blockade immunotherapy and CAR-T cell therapy though more recent data indicate that this may be prevented by

LILRB4 (1,447 words) [view diff] no match in snippet view article find links to article

W, Li Z, Zhang N, An Z, Zhang CC (October 2018). "A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML". Molecular Therapy. 26 (10): 2487–2495

Alvin J. Siteman Cancer Center (4,188 words) [view diff] no match in snippet view article find links to article

system. This "trains" the immune cells to attack tumor cells. 2017 — CAR-T cell therapy and using Zika virus to fight brain cancer In a clinical trial

COVID-19 (33,237 words) [view diff] exact match in snippet view article find links to article

steroid-refractory cytokine release syndrome induced by a different cause, CAR T cell therapy, in 2017. There is no randomised, controlled evidence that tocilizumab

Tocilizumab (3,661 words) [view diff] no match in snippet view article find links to article

approved tocilizumab for cytokine release syndrome, a side effect of CAR-T cell therapies. In June 2021, the US Food and Drug Administration (FDA) issued

American Association for Cancer Research (1,246 words) [view diff] no match in snippet view article find links to article

including immune checkpoint blockade and Chimeric Antigen Receptor (CAR) T-cell therapy. The AACR Foundation for the Prevention and Cure of Cancer is

Leukemia (8,165 words) [view diff] exact match in snippet view article find links to article

PMC 6376657. PMID 30764841. Zheng PP, Kros JM, Li J (June 2018). "Approved CAR T cell therapies: ice bucket challenges on glaring safety risks and long-term

Lenzilumab (1,120 words) [view diff] no match in snippet view article find links to article

reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts". Blood. 133 (7): 697–709. doi:10.1182/blood-2018-10-881722

Cytokine storm (2,786 words) [view diff] exact match in snippet view article find links to article

(March 2018). "Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel". Journal of Hematology & Oncology. 11 (1): 35

Human genetic enhancement (10,491 words) [view diff] exact match in snippet view article find links to article

committee approval statement, ethical, legal norms and human morality. CAR T cell therapy, which is intended to be a new treatment aims to change the genetics

H. Lee Moffitt Cancer Center & Research Institute (2,979 words) [view diff] no match in snippet view article find links to article

of non-Hodgkin's lymphoma. Yescarta is a Chimeric Antigen Receptor (CAR) T cell therapy, also known as CAR-T. Moffitt Cancer Center's Frederick Locke

High-dose chemotherapy and bone marrow transplant (6,147 words) [view diff] no match in snippet view article find links to article

discontinued, a rising therapy for cancer that is similar to HDC/BMT is CAR-T cell therapy, which is a type of immunotherapy. CAR T therapy collects the

Imugene (831 words) [view diff] no match in snippet view article find links to article

activity with mice being cured of their cancer with the CF33-CD19 and CAR T-cell combination, as well as prolonged protective anti-tumour immunity. Solid

Mantle cell lymphoma (4,549 words) [view diff] no match in snippet view article find links to article

Rajashri; Dhamne, Hemant; Yang, Dong-Hua; Zhao, Hong-Bing (31 March 2023). "CAR T-Cell therapy for the management of mantle cell lymphoma". Molecular Cancer

David G. Maloney (1,737 words) [view diff] no match in snippet view article find links to article

CD19-specific CAR. Preliminary results point toward high rates of remission after CAR T-cell infusion. Maloney grew up in Yakima, Washington. He and his wife, Susan

Transcription activator-like effector nuclease (3,147 words) [view diff] case mismatch in snippet view article find links to article

Duchateau P, Poirot L (September 2015). "A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy". Molecular Therapy. 23 (9):

Suzanne Farid (400 words) [view diff] no match in snippet view article find links to article

Farid, Suzanne; Titchener-Hooker, Nigel; Shah, Nilay (2020). "Autologous CAR T-cell therapies supply chain: challenges and opportunities?". Cancer Gene Therapy

Helixmith (1,203 words) [view diff] no match in snippet view article find links to article

(CMT, phase 1/2a). Helixmith’s pipeline extends to CAR-T cell therapy and AAV gene therapy. In CAR-T cell therapy, the company aims at eradicating various

Combinatorial ablation and immunotherapy (1,150 words) [view diff] no match in snippet view article find links to article

and distant tumors. Combining immunotherapy (ie: checkpoint inhibitors, CAR-T cell therapy) and vaccine adjuvants (ie: interferon, saponin) with ablation

Adenosine A2A receptor (5,133 words) [view diff] no match in snippet view article find links to article

of A2AR in this setting has shown to increase tumor clearance through CAR T-cell therapy in mice. Targeting of the A2A receptor is an attractive option

Glypican 2 (865 words) [view diff] no match in snippet view article find links to article

et al. (January 2023). "Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma". Journal for Immunotherapy of Cancer. 11 (1):

John M. Maris (598 words) [view diff] no match in snippet view article find links to article

Dream Team. The research group would use genomics to identify targets for CAR T-cell therapy. In January 2013, Maris co-authored Combination Therapy Targeting

Cell therapy (4,181 words) [view diff] no match in snippet view article find links to article

because of the introduction of new cell and gene therapy products, such as CAR T-cell therapies and allogeneic therapies. Cell and gene therapies require manufacturer

Cancer immunology (3,766 words) [view diff] no match in snippet view article find links to article

Fraietta JA (May 2019). "An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer". American Journal of Hematology. 94 (S1):

Trodusquemine (1,136 words) [view diff] no match in snippet view article find links to article

(March 2022). "PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity". Cancer Discovery. 12 (3): 752–773. doi:10.1158/2159-8290

Affimer (2,484 words) [view diff] no match in snippet view article find links to article

are in discovery and preclinical development to tackle cancer, both via CAR-T cell therapy and as immune checkpoint inhibitors. Early studies using ex vivo

Siddhartha Mukherjee (5,474 words) [view diff] no match in snippet view article find links to article

KN01. doi:10.1158/1535-7163.TARG-17-KN01. Craig, Jessica (10 May 2016). "CAR T-cell start-up launched". mdedge.com. Frontline Medical Communications Inc.

T cell receptor T cell therapy (632 words) [view diff] no match in snippet view article find links to article

3389/fimmu.2019.02250. PMC 6798078. PMID 31681259. "TCR Vs. CAR-T: What is CAR-T Cell, TCR Therapy, and What are They Used For?". Akadeum Life Sciences. 2020-11-23

Li Ka Shing Foundation (2,582 words) [view diff] no match in snippet view article find links to article

University of Sydney to support Australia's first clinical trial testing CAR T-cell immunotherapy in patients with advanced pancreatic cancer—November 2018

Chandler Park (2,780 words) [view diff] no match in snippet view article find links to article

June 2020, he was interviewed to discuss CAR-T Cell and provided information on upcoming treatments for CAR-T cell. Park is also one of the contributing

Caspase-9 (4,330 words) [view diff] exact match in snippet view article find links to article

their targets is critical. One of the various ways to exert control over CAR T cell is through drug-controlled synthetic systems. iCasp9 was created by modifying

Single-domain antibody (3,898 words) [view diff] no match in snippet view article find links to article

(March 2022). "A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer". Molecular Therapy

Bioinstructive material (819 words) [view diff] no match in snippet view article find links to article

and release of genetically engineered T cells. It is an evolution of CAR-T cell therapy. T cells are extracted from the patient and mixed with a genetically

Tumor-infiltrating lymphocytes (2,756 words) [view diff] no match in snippet view article find links to article

efficacy. Lymphocyte Tumor-Infiltrating Dendritic Cell Cancer Immunotherapy CAR T-Cell therapy T-cells Teixeira, Luis; Rothé, Françoise; Ignatiadis, Michail;

Glypican 1 (1,777 words) [view diff] no match in snippet view article find links to article

potential target for cancer therapy, including antibody-drug conjugates, CAR-T cell therapy, radiotherapy, bispecific T cell engager and immunotoxins in preclinical

Craig B. Thompson (2,348 words) [view diff] exact match in snippet view article find links to article

Abatacept (Orencia) for autoimmune diseases and for use in T cell cloning and CAR T cell production. Thompson's work with Stanley Korsmeyer establishing the existence

Anjana Rao (1,412 words) [view diff] exact match in snippet view article find links to article

James P.; Rao, Anjana (2019-02-27). "NR4A transcription factors limit CAR T cell function in solid tumours". Nature. 567 (7749): 530–534. Bibcode:2019Natur

Intracellular delivery (8,788 words) [view diff] no match in snippet view article find links to article

a functional human HBB gene (European and US approvals granted 2022). CAR-T cell immunotherapies: Tisagenlecleucel (branded as Kymriah) for the treatment

Paul A. Hopper (1,281 words) [view diff] exact match in snippet view article find links to article

In 2019 Hopper founded Chimeric Therapeutics to develop a solid tumor CAR T cell therapy licensed from the lab of Professors Christine Brown and Michael

List of prizes known as the Nobel or the highest honors of a field (10,839 words) [view diff] no match in snippet view article find links to article

esteemed Prix Galien Foundation Best Biotechnology Product Award for CAR-T cell therapy, Kymriah® - Novartis US". pharma.us.novartis.com. "TKS Publisher

Sotio (1,170 words) [view diff] no match in snippet view article find links to article

bioprocessonline.com. Retrieved 2022-03-15. "Sotio licences Unum Therapeutics' CAR-T cell portfolio". european-biotechnology.com. 31 August 2020. Retrieved 2022-03-15

Uğur Şahin (6,116 words) [view diff] no match in snippet view article find links to article

broad range of antigens for immunotherapy. Chimeric antigen receptor (CAR)-T cell therapies (CARVAC) are promising immunotherapies for treating B-cell-derived

Eran Elinav (2,491 words) [view diff] no match in snippet view article find links to article

non-antibiotic-disrupted gut microbiome associated with clinical responses to CD19-CAR-T cell cancer immunotherapy". Nature Medicine. 29 (4): 906–916. doi:10.1038/s41591-023-02234-6

Aggressive lymphoma (1,402 words) [view diff] no match in snippet view article find links to article

against diffuse large B-cell lymphoma are chimeric antigen receptor (CAR) T cell therapy and therapeutic blocking of programmed cell death protein 1 pathway

List of people from Houston (4,244 words) [view diff] no match in snippet view article find links to article

the Center for Cell & Gene Therapy at Baylor College of Medicine and CAR T-cell therapy pioneer Denton Cooley, heart surgeon Michael DeBakey, heart surgeon

He Jiankui affair (12,403 words) [view diff] no match in snippet view article find links to article

their own cancer cells after CRISPR editing. The experiment was based on CAR T-cell therapy by which the T cells, obtained from the individuals were removed

GEMoaB Monoclonals (726 words) [view diff] no match in snippet view article find links to article

Sciences, Cellex Cell Professionals, and Intellia Therapeutics Launch New CAR T-Cell Company". Blackstone. 22 June 2021. Retrieved 12 February 2024. M. Cartellieri

The Immune Response Corporation (1,741 words) [view diff] no match in snippet view article find links to article

Fortune Magazine. August 30, 2017. "Press Announcements - FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma".

Nirogacestat (837 words) [view diff] case mismatch in snippet view article find links to article

Kinetics/Pharmacodynamics of ALLO-715 to Evaluate an Anti-BCMA Allogeneic CAR T Cell Therapy With or Without Nirogacestat in Subjects With Relapsed/Refractory

Timeline of biotechnology (24,488 words) [view diff] no match in snippet view article find links to article

method without expensive viral vectors, enabling e.g. novel anti-cancer CAR-T cell therapies. [relevant?]Wastewater surveillance, which substantially expanded

Pierre Charneau (860 words) [view diff] no match in snippet view article find links to article

Retrieved 2019-01-30. "Novartis receives first ever FDA approval for a CAR-T cell therapy, Kymriah(TM) (CTL019), for children and young adults with B-cell

TEDxTauranga (1,312 words) [view diff] no match in snippet view article find links to article

Words have the Power to end suffering of LGBTQ youth" Rob Weinkove - "CAR T-cell therapy: Reprogramming the immune system to treat Cancer " David Downs

2022 in science (49,140 words) [view diff] no match in snippet view article find links to article

method without expensive viral vectors, enabling e.g. novel anti-cancer CAR-T cell therapies. 26 August – Researchers report the development of greenhouses

AmadeoLab (2,282 words) [view diff] no match in snippet view article find links to article

sulfate proteoglycan 4 in glioblastoma and neurospheres:Implications for CAR-T cell therapy" (PDF). Sci. Transl. Med. 10. "Le aree di ricerca in INT". istitutotumori

Off-target genome editing (6,846 words) [view diff] case mismatch in snippet view article find links to article

Miskin J, Wonnacott K, Keir C (March 2017). "Global Manufacturing of CAR T Cell Therapy". Molecular Therapy: Methods & Clinical Development. 4: 92–101

Primary cutaneous diffuse large B-cell lymphoma, leg type (2,669 words) [view diff] exact match in snippet view article find links to article

007. PMID 29126866. S2CID 25304758. Chavez JC, Locke FL (June 2018). "CAR T cell therapy for B-cell lymphomas". Best Practice & Research. Clinical Haematology