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Longer titles found: DNA ligase (NAD+) (view), DNA ligase 1 (view), DNA ligase 3 (view), DNA ligase 4 (view)

searching for DNA ligase 80 found (191 total)

alternate case: dNA ligase

In vitro recombination (429 words) [view diff] exact match in snippet view article find links to article

by digestion, ligase the foreign DNA into the vector with the enzyme DNA ligase. And DNA is inserted by introducing the DNA into bacteria cells by transformation

Non-homologous end joining (3,683 words) [view diff] exact match in snippet view article find links to article

necessitating a specialized NHEJ polymerase. The DNA ligase IV complex, consisting of the catalytic subunit DNA ligase IV and its cofactor XRCC4 (Dnl4 and Lif1

Omenn syndrome (515 words) [view diff] no match in snippet view article find links to article

and RAG2), Interleukin-7 receptor-α (IL7Rα), DCLRE1C-Artemis, RMRP-CHH, DNA-Ligase IV, common gamma chain, WHN-FOXN1, ZAP-70 and complete DiGeorge syndrome

LIG4 syndrome (400 words) [view diff] case mismatch in snippet view article find links to article

IV syndrome) is an extremely rare condition caused by mutations in the DNA Ligase IV (LIG4) gene. Some mutations in this gene are associated with a resistance

Non-homologous end-joining factor 1 (1,652 words) [view diff] exact match in snippet view article find links to article

diversity in the antibody repertoire of the immune system. XLF interacts with DNA ligase IV and XRCC4 and is thought to be involved in the end-bridging or ligation

DNA mismatch repair (4,179 words) [view diff] exact match in snippet view article find links to article

lagging-strand DNA transiently contains nicks (before being sealed by DNA ligase) and provides a signal that directs mismatch proofreading systems to the

Baldomero Olivera (425 words) [view diff] exact match in snippet view article find links to article

neuromuscular synapses. He discovered and first characterized E. coli DNA ligase, a key enzyme of genetic engineering and recombinant DNA technology. Olivera

Tom Blundell (2,180 words) [view diff] exact match in snippet view article find links to article

nerve growth factor, the RAD51-BRCA2 DNA recombination complex, and the DNA ligase shown at right. His group has written several broadly used bioinformatics

RecQ helicase (1,899 words) [view diff] exact match in snippet view article find links to article

WRN also physically interacts with the major NHEJ factor X4L4 (XRCC4-DNA ligase 4 complex). X4L4 stimulates WRN exonuclease activity that likely facilitates

Nucleotidyltransferase (398 words) [view diff] exact match in snippet view article find links to article

of the 5'-dRP group by a'-elimination reaction, and 5) nick sealing by DNA ligase (36, 37) Nucleotidyltransferases at the U.S. National Library of Medicine

Dubowitz syndrome (1,190 words) [view diff] exact match in snippet view article find links to article

in the DNA ligase IV LIG4 gene. This finding suggests that the molecular basis for at least a subset of Dubowitz syndrome cases is a DNA ligase IV defect

Purine analogue (186 words) [view diff] exact match in snippet view article find links to article

analogues Fludarabine inhibits multiple DNA polymerases, DNA primase, and DNA ligase I, and is S phase-specific (since these enzymes are highly active during

UvrABC endonuclease (493 words) [view diff] exact match in snippet view article find links to article

UvrB in the process, and the last phosphodiester bond is completed by DNA ligase. DNA repair endonuclease Nucleotide excision repair DNA Grossman L, Yeung

Pospiviroidae (480 words) [view diff] exact match in snippet view article find links to article

The termini of the resulting linear monomers are ligated by the host DNA ligase 1 to generate the mature circular viroid RNA. Apscaviroid Apple dimple

DNA polymerase mu (702 words) [view diff] exact match in snippet view article find links to article

end joining (NHEJ) pathway of DNA repair. Pol μ interacts with Ku and DNA ligase IV, which also participate in NHEJ. It is structurally and functionally

Ligase chain reaction (612 words) [view diff] exact match in snippet view article find links to article

was first developed in 1989 by multiple groups, who used thermostable DNA ligase to discriminate between normal and mutant DNA and to amplify the allele-specific

Natural competence (1,906 words) [view diff] exact match in snippet view article find links to article

cell 5-Bacterial cell restriction enzyme 6-Unwound foreign plasmid 7-DNA ligase I: A plasmid of foreign DNA from a dead cell is intercepted by the sex

Deamination (708 words) [view diff] exact match in snippet view article find links to article

activity, followed by a fill-in reaction by its polymerase activity. DNA ligase then forms a phosphodiester bond to seal the resulting nicked duplex product

Stanley Norman Cohen (2,603 words) [view diff] exact match in snippet view article find links to article

the DNA segments aligned themselves and were afterwards joined using DNA ligase. The plasmids were then transferred into a strain of E. coli and plated

AHNAK (1,099 words) [view diff] exact match in snippet view article find links to article

Kysela B (March 2004). "AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation". DNA Repair

Massive parallel sequencing (3,051 words) [view diff] exact match in snippet view article find links to article

sequence extension reaction is not carried out by polymerases but rather by DNA ligase and either one-base-encoded probes or two-base-encoded probes. In its

Simon Boulton (1,928 words) [view diff] exact match in snippet view article find links to article

cell. A special enzyme, DNA ligase (shown here in color), encircles the double helix to repair a broken strand of DNA. DNA ligase is responsible for repairing

Sulfophobococcus (226 words) [view diff] exact match in snippet view article find links to article

preliminary crystallographic analysis of a multiple cofactor-dependent DNA ligase from". Acta Crystallographica Section F. 66 (12). Commerce Place, 350

MUTYH (2,953 words) [view diff] exact match in snippet view article find links to article

it does this by enzymatic activity, namely polymerase and dRP lyase. DNA ligase is used to seal the fragments after dRP excision causes the formation

Protein engineering (7,486 words) [view diff] exact match in snippet view article find links to article

gaps. The USER enzyme treated fragments are mixed and ligated using T4 DNA ligase and subjected to Dpn1 digestion to remove the template DNA. These resulting

Aladin (protein) (1,393 words) [view diff] exact match in snippet view article

nuclear import of aprataxin, a repair protein for single-strand breaks, and DNA ligase I, employed in DNA base excision repair. These decreases in DNA repair

Agata Smogorzewska (675 words) [view diff] exact match in snippet view article find links to article

anaemia and the repair of Watson and Crick DNA crosslinks – Nature, 2013 DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2 – Current

11β-Hydroxysteroid dehydrogenase type 1 (1,336 words) [view diff] exact match in snippet view article find links to article

CK, Shuman S (October 1999). "Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in

Werner syndrome (4,517 words) [view diff] exact match in snippet view article find links to article

protein also physically interacts with the major NHEJ factor X4L4 (XRCC4-DNA ligase 4 complex). X4L4 stimulates WRN exonuclease activity that likely facilitates

TFIP11 (682 words) [view diff] exact match in snippet view article find links to article

break repair via nonhomologous end joining RNA splicing negative regulation of DNA ligase activity mRNA splicing, via spliceosome Sources:Amigo / QuickGO

SMC2 (1,317 words) [view diff] exact match in snippet view article find links to article

SM, Chen DJ, Cary RB (Feb 2003). "In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex". Molecular Biology of the

MYBPC1 (849 words) [view diff] exact match in snippet view article find links to article

(1986). "Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17". Gene. 41 (2–3): 321–5. doi:10.1016/0378-1119(86)90114-9.

Germination (3,817 words) [view diff] exact match in snippet view article find links to article

G, Bhardwaj RM, Jiang Q, Bray CM, West CE (September 2010). "A plant DNA ligase is an important determinant of seed longevity". The Plant Journal. 63

PARP3 (755 words) [view diff] exact match in snippet view article find links to article

glycosyltransferase activity catalytic activity NAD+ ADP-ribosyltransferase activity DNA ligase (ATP) activity protein ADP-ribosylase activity protein binding NAD DNA

Seed (9,452 words) [view diff] exact match in snippet view article find links to article

storage. Upon germination, seeds of Vicia faba undergo DNA repair. A plant DNA ligase that is involved in repair of single- and double-strand breaks during

Triple-A syndrome (1,595 words) [view diff] exact match in snippet view article find links to article

import of aprataxin, a repair protein for DNA single-strand breaks, and DNA ligase I. These decreases in DNA repair proteins may allow accumulation of DNA

Nucleoporin (2,145 words) [view diff] exact match in snippet view article find links to article

to oxidative stress. The import of DNA repair proteins aprataxin and DNA ligase I is selectively decreased, and this may increase the vulnerability of

Bacteriophage experimental evolution (2,791 words) [view diff] exact match in snippet view article find links to article

2002. Experimental genomic evolution: extensive compensation for loss of DNA ligase activity in a virus. Mol. Biol. Evol. 19:230-238. Burch, C. L., and L

PARP2 (1,307 words) [view diff] exact match in snippet view article find links to article

ontology Molecular function transferase activity DNA binding protein binding DNA ligase (ATP) activity glycosyltransferase activity NAD+ ADP-ribosyltransferase

Illumina dye sequencing (1,984 words) [view diff] exact match in snippet view article find links to article

and left adapters will need to be attached by T7 DNA Polymerase and T4 DNA ligase after sonication. Strands that fail to have adapters ligated are washed

Mycobacterium smegmatis (2,153 words) [view diff] exact match in snippet view article find links to article

requires the Ku protein and a specialized poly-functional ATP-dependent DNA ligase (ligase D). NHEJ is efficient but inaccurate. Sealing of blunt DNA ends

MRE11A (2,149 words) [view diff] exact match in snippet view article find links to article

endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using

CCDC176 (678 words) [view diff] case mismatch in snippet view article find links to article

likely interaction is with LIG4, a human gene that encodes the protein DNA Ligase IV. Two experiments in a publication of 1030 unique reactions support

ADP-ribosylation (3,535 words) [view diff] exact match in snippet view article find links to article

remove the overhanging 5' flap. The last step of DNA repair involves DNA ligase which brings the final DNA strands together in a phosphodiester bond.

Regulatory sequence (2,839 words) [view diff] case mismatch in snippet view article find links to article

non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand breaks within

Aprataxin (1,511 words) [view diff] case mismatch in snippet view article find links to article

Aprataxin removes AMP from DNA ends following abortive ligation attempts by DNA Ligase IV during non-homologous end joining, thereby permitting subsequent attempts

SETMAR (1,594 words) [view diff] case mismatch in snippet view article find links to article

"The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining"

NTHL1 (1,349 words) [view diff] exact match in snippet view article find links to article

Tomkinson AE, Wallace SS, Pederson DS (2011). "Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair". Mol. Cell. Biol. 31

Bloom syndrome (2,759 words) [view diff] exact match in snippet view article find links to article

N, Lieber MR, Koyama H (2004). "Genetic interactions between BLM and DNA ligase IV in human cells". J. Biol. Chem. 279 (53): 55433–42. doi:10.1074/jbc

MLH1 (3,414 words) [view diff] exact match in snippet view article find links to article

repair genes) include DNA polymerase delta, PCNA, RPA, HMGB1, RFC and DNA ligase I, plus histone and chromatin modifying factors. Only a minority of sporadic

Ancestry-informative marker (1,568 words) [view diff] exact match in snippet view article find links to article

endonuclease, which modifies the DNA sequence. This enzyme can be used with DNA ligase (connecting two different DNA), modifying DNA by inserting DNA from other

TOP2B (2,287 words) [view diff] case mismatch in snippet view article find links to article

non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks within

PNKP (1,881 words) [view diff] exact match in snippet view article find links to article

links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV". EMBO J. 23 (19): 3874–85. doi:10.1038/sj.emboj.7600375. PMC 522785

Hematopoietic stem cell (4,500 words) [view diff] exact match in snippet view article find links to article

polymerase mu and NHEJ factor 1 (NHEJ1, also known as Cernunnos or XLF). DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks

DNA-deoxyinosine glycosylase (1,346 words) [view diff] exact match in snippet view article find links to article

phosphodiester backbone at the specified location. DNA polymerase and DNA ligase then completes the process by incorporating the correct base pair and

ClickSeq (1,160 words) [view diff] exact match in snippet view article find links to article

mechanical or enzymatic fragmentation of the sample RNA Removal of RNA/DNA ligase enzymes: In ClickSeq, there are no RNA or DNA ligation steps, as are commonly

Senescence (7,159 words) [view diff] exact match in snippet view article find links to article

attenuation of DNA repair and response pathways that depends on HSC quiescence. DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks

Stem cell theory of aging (2,579 words) [view diff] exact match in snippet view article find links to article

attenuation of DNA repair and response pathways that depends on HSC quiescence. DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks

Genome instability (4,560 words) [view diff] exact match in snippet view article find links to article

perfect copy of DNA. Mutations of proteins such as DNA polymerase or DNA ligase can lead to impairment of replication and lead to spontaneous chromosomal

HIV integration (2,137 words) [view diff] exact match in snippet view article find links to article

5’ dinucleotide "flaps" on the HIV DNA. Lastly, it is thought that the DNA ligase enzymes join the remaining unbound segment of the HIV and host DNA strands

OB-fold (912 words) [view diff] exact match in snippet view article find links to article

junction branch migration complex) Minichromosome maintenance (MCM) proteins DNA ligase III RecO (recombination mediator) OB-folds are structurally similar to

Penelope Jeggo (1,620 words) [view diff] case mismatch in snippet view article find links to article

Jeggo studied aging and stem cells. She found that the inability of DNA Ligase IV to repair breaks in stem cell DNA contributes to the aging of our cells

Deoxyribozyme (4,795 words) [view diff] exact match in snippet view article find links to article

Although each repeating unit in a RNA strand owns a free hydroxyl group, the DNA ligase takes just one of them as a branching starting point. This cannot be done

PARP1 (4,239 words) [view diff] exact match in snippet view article find links to article

ontology Molecular function transferase activity DNA binding R-SMAD binding DNA ligase (ATP) activity protein N-terminus binding glycosyltransferase activity

DNA-PKcs (3,754 words) [view diff] exact match in snippet view article find links to article

transcription regulator complex nucleoplasm DNA-dependent protein kinase-DNA ligase 4 complex nonhomologous end joining complex extracellular matrix nucleus

Transformation efficiency (2,952 words) [view diff] exact match in snippet view article find links to article

Retrieved 2023-01-25. Ymer S (December 1991). "Heat inactivation of DNA ligase prior to electroporation increases transformation efficiency". Nucleic

Thermococcus (3,022 words) [view diff] exact match in snippet view article find links to article

Mardanov AV, Polyakov KM, Volkov VV, et al. (December 2012). "ATP-dependent DNA ligase from Thermococcus sp. 1519 displays a new arrangement of the OB-fold domain"

Memory (16,670 words) [view diff] case mismatch in snippet view article find links to article

non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks within

University of Utah College of Science (3,897 words) [view diff] exact match in snippet view article find links to article

Mathematicians Baldomero Olivera – discovered and first characterized E. coli DNA ligase, a key enzyme of genetic engineering and recombinant DNA technology Thomas

List of University of Utah people (5,516 words) [view diff] exact match in snippet view article find links to article

Fellow Baldomero Olivera – discovered and first characterized E. coli DNA ligase, a key enzyme of genetic engineering and recombinant DNA technology Thomas

DNA damage (naturally occurring) (10,128 words) [view diff] exact match in snippet view article

mdanderson.org. Abdou I, Poirier GG, Hendzel MJ, Weinfeld M (January 2015). "DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of

RAD9A (3,997 words) [view diff] exact match in snippet view article find links to article

endonuclease 1 (APE1), polymerase β (Polβ), Flap endonuclease 1 (FEN1), and DNA ligase I. During DNA replication, a number of point mutations can occur, where

IFFO1 (1,758 words) [view diff] exact match in snippet view article find links to article

differentiation of erythroid and megakaryocytic lineages XRCC4: work with DNA ligase IV and DNA-dependent protein kinase in DNA repair of double-stranded breaks

Reprogramming (5,387 words) [view diff] exact match in snippet view article find links to article

PMID 16585517. Abdou I, Poirier GG, Hendzel MJ, Weinfeld M (January 2015). "DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of

Proximity extension assay (927 words) [view diff] exact match in snippet view article find links to article

PEA is derived from the proximity ligation assay (PLA) which uses a DNA ligase enzyme to unite the sequences of the proximity probes instead of a DNA

Glossary of cellular and molecular biology (0–L) (29,380 words) [view diff] exact match in snippet view article

removed and replaced with DNA, and the Okazaki fragments are joined by DNA ligase. lampbrush chromosome A transcriptionally active, highly de-condensed

Stress granule (12,460 words) [view diff] case mismatch in snippet view article find links to article

receptor LEMD3 LEMD3 Inner nuclear membrane protein Man1 LIG3 DNA Ligase 3 DNA Ligase 3 LIN28A LIN28A Lin-28 Homolog A LIN28B LIN28B Lin-28 Homolog B

Epigenetics in learning and memory (6,235 words) [view diff] case mismatch in snippet view article find links to article

non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks within

Zoe Shabarova (1,945 words) [view diff] exact match in snippet view article find links to article

Retrieved 2023-11-19. A.V. Tsytovich, N.G. Dolinnaia, Z.A. Shabarova. T4-DNA ligase: Substrate properties of synthetic DNA-duplexes with structural anomalies

Glossary of cellular and molecular biology (M–Z) (24,915 words) [view diff] exact match in snippet view article

synthesized discontinuously by DNA polymerase and later linked together by DNA ligase to create the lagging strand during DNA replication. Okazaki fragments