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searching for DNA mismatch repair 56 found (137 total)

MLH3 (1,528 words) [view diff] exact match in snippet view article find links to article

DNA mismatch repair protein Mlh3 is a protein that in humans is encoded by the MLH3 gene. This gene is a member of the MutL-homolog (MLH) family of DNA

Lewis lung carcinoma (1,355 words) [view diff] exact match in snippet view article find links to article

metabolic mutagens, spontaneous 5–methylcytosine deamination, defective DNA mismatch repair, and reactive oxygen species. Our data also suggest that LLC is a

Magnus von Knebel Doeberitz (1,095 words) [view diff] exact match in snippet view article find links to article

relate to mechanisms of human carcinogenesis by papillomaviruses and DNA mismatch repair deficiency, the identification of novel diagnostic markers and potential

MSH4 (1,522 words) [view diff] no match in snippet view article find links to article

F, Saunières A, Gaudray P, Paquis-Flucklinger V (Jul 2002). "The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role

RNASEH2A (582 words) [view diff] exact match in snippet view article find links to article

ribonuclease H2 complex nucleus nucleoplasm cytosol Biological process DNA mismatch repair DNA replication RNA catabolic process RNA metabolic process nucleic

POLD4 (511 words) [view diff] exact match in snippet view article find links to article

cellular response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA replication DNA mismatch repair Sources:Amigo / QuickGO

Richard Kolodner (635 words) [view diff] exact match in snippet view article find links to article

DNA mismatch repair and the pathways that prevent genome instability. While studying DNA repair in bacteria and yeast, Kolodner identified two DNA mismatch

MSH5 (1,442 words) [view diff] exact match in snippet view article find links to article

encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a

Frameshift mutation (4,728 words) [view diff] exact match in snippet view article find links to article

mutations are more likely to occur in a region of repeat sequence. When DNA mismatch repair does not fix the addition or deletion of bases, these mutations are

POLD2 (899 words) [view diff] exact match in snippet view article find links to article

response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA mismatch repair DNA biosynthetic process Sources:Amigo / QuickGO

POLD3 (740 words) [view diff] exact match in snippet view article find links to article

stimulus telomere maintenance via semi-conservative replication DNA mismatch repair DNA strand elongation involved in DNA replication DNA synthesis involved

Hyperplastic polyp (718 words) [view diff] no match in snippet view article find links to article

potential. This occurs through multiple mutations that affect the DNA-mismatch-repair pathways. As such DNA mutations during replication are not repaired

RPA4 (376 words) [view diff] exact match in snippet view article find links to article

change DNA unwinding involved in DNA replication base-excision repair DNA mismatch repair mitotic recombination telomere maintenance via telomerase reciprocal

Tandem repeat (1,284 words) [view diff] exact match in snippet view article find links to article

instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair". Oncogene. 18 (12): 2143–7. doi:10.1038/sj.onc.1202583. PMID 10321739

Amsterdam criteria (721 words) [view diff] exact match in snippet view article find links to article

Bellizzi AM, Frankel WL (2009). "Colorectal cancer due to deficiency in DNA mismatch repair function: a review". Advances in Anatomic Pathology. 16 (6): 405–417

Locked nucleic acid (1,647 words) [view diff] exact match in snippet view article find links to article

or close to the intended site of modification offers evasion of DNA mismatch repair due to the higher thermodynamic stability it has. Elayadi, Anissa

Chromosome segregation (1,706 words) [view diff] exact match in snippet view article find links to article

Surtees J, Alani E (2014). "Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289

Genetic predisposition (1,779 words) [view diff] exact match in snippet view article find links to article

the most common, and results from inherited pathogenic variants in DNA mismatch repair genes such as MLH1, MSH2, and MSH6. Inheriting these mutations impairs

SETD2 (931 words) [view diff] exact match in snippet view article find links to article

histone H3-K36 trimethylation embryonic cranial skeleton morphogenesis DNA mismatch repair histone lysine methylation forebrain development regulation of double-strand

Replication protein A1 (1,549 words) [view diff] exact match in snippet view article find links to article

stimulus DNA replication regulation of cellular response to heat DNA mismatch repair translesion synthesis transcription-coupled nucleotide-excision repair

Replication protein A3 (920 words) [view diff] exact match in snippet view article find links to article

semi-conservative replication G1/S transition of mitotic cell cycle DNA mismatch repair nucleotide-excision repair, DNA incision, 3'-to lesion regulation

P73 (1,132 words) [view diff] exact match in snippet view article find links to article

positive regulation of apoptotic process regulation of gene expression DNA mismatch repair cell cycle negative regulation of cardiac muscle cell proliferation

Chrysochromulina ericina virus (700 words) [view diff] exact match in snippet view article find links to article

C.; Duarte, Amy; Ogata, Hiroyuki (October 2014). "Development of DNA mismatch repair gene, MutS, as a diagnostic marker for detection and phylogenetic

Thymine-DNA glycosylase (1,613 words) [view diff] exact match in snippet view article find links to article

depyrimidination DNA demethylation base-excision repair DNA repair DNA mismatch repair regulation of gene expression, epigenetic base-excision repair, AP

Giant virus (2,237 words) [view diff] exact match in snippet view article find links to article

were 183 listed. 1Mutator S (MutS) and its homologs are a family of DNA mismatch repair proteins involved in the mismatch repair system that acts to correct

John Burn (geneticist) (1,099 words) [view diff] exact match in snippet view article

PMID 16943400. Dunlop, M. (1997). "Cancer risk associated with germline DNA mismatch repair gene mutations". Human Molecular Genetics. 6 (1): 105–110. doi:10

MAX (gene) (2,166 words) [view diff] exact match in snippet view article

Crouch DH, Durant ST, et al. (February 2003). "Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX". Oncogene. 22 (6): 819–825

Replication protein A2 (1,479 words) [view diff] exact match in snippet view article find links to article

of DNA damage checkpoint regulation of cellular response to heat DNA mismatch repair translesion synthesis transcription-coupled nucleotide-excision repair

Plastid (3,287 words) [view diff] exact match in snippet view article find links to article

chloroplasts of the moss Physcomitrella patens, a protein employed in DNA mismatch repair (Msh1) interacts with proteins employed in recombinational repair

Tioguanine (1,954 words) [view diff] exact match in snippet view article find links to article

et al. (January 2023). "Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance". Cancer Cell.

TREX1 (1,425 words) [view diff] exact match in snippet view article find links to article

recombination regulation of type I interferon production DNA replication DNA mismatch repair nucleic acid phosphodiester bond hydrolysis DNA metabolic process

Tumor suppressor gene (3,415 words) [view diff] exact match in snippet view article find links to article

other tumor suppressors and activation of oncogenes. (e.g., p53 and DNA mismatch repair protein 2 (MSH2)). Certain genes can also act as tumor suppressors

Physcomitrella patens (2,426 words) [view diff] exact match in snippet view article find links to article

PpRAD51 is also essential for resistance to ionizing radiation. The DNA mismatch repair protein PpMSH2 is a central component of the P. patens mismatch repair

Chromosomal crossover (3,779 words) [view diff] exact match in snippet view article find links to article

145631.112. PMC 3589530. PMID 23212949. Kunkel TA, Erie DA (2005). "DNA mismatch repair". Annual Review of Biochemistry. 74 (1): 681–710. doi:10.1146/annurev

Temozolomide (2,971 words) [view diff] exact match in snippet view article find links to article

PMC 3586545. PMID 22237395. Li Z, Pearlman AH, Hsieh P (February 2016). "DNA mismatch repair and the DNA damage response". DNA Repair. 38: 94–101. doi:10.1016/j

Nicola Royle (1,342 words) [view diff] exact match in snippet view article find links to article

terminal deletion syndromes. Royle and her group showed that defects in DNA mismatch repair (MMR), particularly loss of MSH2, in colon cancers causes telomere

Randomness (4,316 words) [view diff] exact match in snippet view article find links to article

Shao Jian; Mithani, Aziz; Harberd, Nicholas P. (January 2018). "DNA mismatch repair preferentially protects genes from mutation". Genome Research. 28

ABL (gene) (3,502 words) [view diff] exact match in snippet view article

ERK1 and ERK2 cascade transitional one stage B cell differentiation DNA mismatch repair Bergmann glial cell differentiation peptidyl-tyrosine phosphorylation

Holliday junction (3,962 words) [view diff] exact match in snippet view article find links to article

Surtees J, Alani E (2014). "Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289

Intraepithelial lymphocyte (2,531 words) [view diff] exact match in snippet view article find links to article

Frankel WL (November 2009). "Colorectal cancer due to deficiency in DNA mismatch repair function: a review". Advances in Anatomic Pathology. 16 (6): 405–417

MUTYH (2,955 words) [view diff] exact match in snippet view article find links to article

process DNA repair metabolism depurination cellular response to DNA damage stimulus DNA mismatch repair base-excision repair Sources:Amigo / QuickGO

DNA ligase 1 (2,893 words) [view diff] exact match in snippet view article find links to article

damage stimulus cell division DNA replication V(D)J recombination DNA mismatch repair DNA ligation involved in DNA repair cell cycle transcription-coupled

Glioma (7,034 words) [view diff] exact match in snippet view article find links to article

levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2". Proceedings of the National Academy of Sciences of the

Proliferating cell nuclear antigen (6,241 words) [view diff] exact match in snippet view article find links to article

regulation of DNA replication response to lipid heart development DNA mismatch repair cellular response to DNA damage stimulus mitotic telomere maintenance

Male infertility (7,688 words) [view diff] exact match in snippet view article find links to article

Common inherited variants in genes that encode enzymes employed in DNA mismatch repair are associated with increased risk of sperm DNA damage and male infertility

Myc (7,405 words) [view diff] exact match in snippet view article find links to article

AG, Gillespie DA, Brown R (February 2003). "Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX". Oncogene. 22 (6): 819–25

Whole genome sequencing (9,500 words) [view diff] exact match in snippet view article find links to article

S2CID 19353116. Supek, Fran; Lehner, Ben (May 2015). "Differential DNA mismatch repair underlies mutation rate variation across the human genome". Nature

Oncogenomics (7,684 words) [view diff] exact match in snippet view article find links to article

synthetically lethal with BRCA-deficiency. Mutations in genes employed in DNA mismatch repair (MMR) cause a high mutation rate. In tumors, such frequent subsequent

Endometrial cancer (10,813 words) [view diff] exact match in snippet view article find links to article

ISBN 978-0-323-06986-1. Guillotin D, Martin SA (November 2014). "Exploiting DNA mismatch repair deficiency as a therapeutic strategy". Experimental Cell Research

Mendel Lectures (857 words) [view diff] case mismatch in snippet view article find links to article

Center / Howard Hughes Medical Institute, Durham, USA "Mechanisms in DNA Mismatch Repair" Nobel Prize 2015 15 103 October 12, 2017 Erich Nigg University of

Biological effects of radiation on the epigenome (3,620 words) [view diff] exact match in snippet view article find links to article

heterochromatin to relax, allowing increased transcription to occur. The DNA mismatch repair gene (MSH2) promoter has shown a hypermethylation pattern when exposed

Tumor antigens recognized by T lymphocytes (2,942 words) [view diff] exact match in snippet view article find links to article

colorectal carcinomas that have hypermutated DNA owing to defects in the DNA mismatch repair pathway. Cancer-germline genes are an important source of tumor-specific

DNA damage theory of aging (11,163 words) [view diff] exact match in snippet view article find links to article

levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2". Proceedings of the National Academy of Sciences. 94 (7):

Somatic evolution in cancer (9,928 words) [view diff] exact match in snippet view article find links to article

levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2". Proceedings of the National Academy of Sciences of the

Oncotype DX Colon Cancer Assay (2,371 words) [view diff] exact match in snippet view article find links to article

et al. Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C

Stress granule (12,563 words) [view diff] exact match in snippet view article find links to article

Protein 2 MOV10 MOV-10 Mov10 RISC Complex RNA Helicase yes MSH6 MSH6 DNA mismatch repair protein Msh6 MSI1 Musashi-1 Musashi RNA Binding Protein 1 yes MSI2