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searching for Tumor suppressor gene 371 found (573 total)

alternate case: tumor suppressor gene

HIC1 (900 words) [view diff] exact match in snippet view article find links to article

MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer". Oncogene. 16 (16): 2159–64. doi:10.1038/sj

development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region

carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. GRCh38: Ensembl release 89: ENSG00000144724 – Ensembl, May 2017

invasion, and progression of various malignant tumors. RFC acts as a tumor suppressor gene. The 5 subunits of replication factor C are 1.RFC1[140KDa] 2.RFC2[40KDa]

several types of human tumours suggest the presence of a potential tumor suppressor gene. This disorder occurs in approximately 1 in 40,000 live births Chromosome

with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. DIRAS3

hepatic stellate cell His laboratory has also discovered a novel tumor suppressor gene, KLF6 that is inactivated in a number of human cancers including

colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. Protein structure prediction methods suggest

reactivated function as a competing endogenous RNA regulating the tumor suppressor gene PTEN. GRCh38: Ensembl release 89: ENSG00000237984 – Ensembl, May

suppressor. Zbtb7 is also involved in the regulation of p53, another tumor suppressor gene. As an oncogene, Zbtb7 is overexpressed in many types of cancer

susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Research. 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430

in humans is encoded by the TUSC3 gene. This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate

LRRC3B gene could be involved in the process of carcinogenesis as a tumor suppressor gene. Haraldson K, Kashuba VI, Dmitriev AA, Senchenko VN, Kudryavtseva

"Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics. 76 (3–4): 176–8. doi:10

malignancies. It is associated with mutations in PTEN on 10q23.3, a tumor suppressor gene otherwise known as phosphatase and tensin homolog, that results

genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the

gene family and demonstration that a human homolog PTCH1 is a key tumor suppressor gene for the Hedgehog signaling pathway as well as the causative gene

and 17 (aqua) and to the 9p21 band (gold) location of the P16 tumor suppressor gene. Adv Anat Pathol. 2008 Sep;15(5):279-86. doi: 10.1097/PAP.0b013e3181832320

Kettering Cancer Center. He is recognized for his research on the tumor suppressor gene, p53, which is mutated in nearly half of cancers. Lowe was born

generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation

the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene. NKX3-1 is an androgen-regulated, prostate-specific homeobox gene

further investigated and resulted in the first reported example of a tumor suppressor gene, RB. Monteiro, Alvaro N.A.; Waizbort, Ricardo (2007-05-30). "The

Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers

a protein that in humans is encoded by the WTAP gene. The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional

In particular, he distinguished himself for having isolated the tumor suppressor gene, the RB2/p130, subsequently demonstrating how the same gene, introduced

Xia Laboratory. He is best known for his discovery of the PALB2 tumor suppressor gene, a notable scientific advance in the field of cancer genetics. Xia

decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding

decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding

gene domain of 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann

"Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth

of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three

defined a direct link between ALOX15 gene activity and an established tumor-suppressor gene located in close chromosomal proximity. Kelavkar and Badr (1999)

first arrived at Wistar, one of his research priorities was the tumor suppressor gene wt1 and its role in the development of Wilms' tumor. Rauscher's

loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer". Proceedings of the National Academy of Sciences

on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein

suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536. Wiemann

modulates transcriptional activation. It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and

Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human

this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three

commonly (96% of patients) an abnormality in the WT1 gene (Wilms tumor suppressor gene). These abnormalities include changes in certain exons (9 and 8)

Lerman M, Roth J, Minna JD (Oct 2001). "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to

cells. Moreover, UV radiation frequently leads to mutations in the tumor suppressor gene p53 in photocarcinogenesis. Determination of photocarcinogenicity

has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms

Nahmias C (June 2006). "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma". Molecular and Cellular

"Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5

phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity of cancer tumors to insulin

prostate cancer occur through chromoplexy, such as disruption of the tumor suppressor gene PTEN or creation of the TMPRSS2-ERG fusion gene.[citation needed]

Though its function is not fully understood, it appears to be a tumor suppressor gene that restricts cell growth and division. Versions of FLCN have been

familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene". Cancer Res. 64 (15): 5113–7. doi:10.1158/0008-5472.CAN-04-0307

suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536. "Entrez

Hong WK, Lotan R (2003). "Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and

the arm of chromosome 17. NF2 is caused by a mutation on the NF2 tumor suppressor gene on chromosome 22. Schwannomatosis is caused by various mutations

Porteous DJ, Smyth JF, Gabra H, Watson JE (2001). "WWOX: A candidate tumor suppressor gene involved in multiple tumor types". Proc. Natl. Acad. Sci. U.S.A

"Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. doi:10.1006/bbrc

determines whether the expression of Myc leads to tumor formation. The tumor suppressor gene TP53 has also been shown to be regulated by a CPE. Cell lines that

exploited a synthetic lethal approach, arose by means of an inactivated tumor suppressor gene (BRCA1 and 2), a treatment which received FDA approval in 2016 (PARP

internal auditory canal and sigmoid sinus). The von Hippel–Lindau tumor suppressor gene generally has a germline mutation. This suppressor gene is also

P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21):

internal auditory canal and sigmoid sinus). The von Hippel–Lindau tumor suppressor gene generally has a germline mutation. This suppressor gene is also

kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region". Mol Cell Biol. 16 (3): 868–76. doi:10.1128/mcb.16.3.868

found to play a key role in memory formation within neurons and tumor-suppressor gene activation in cancer treatment respectively. Epigenetic priming

tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene". Oncogene. 15 (15): 1797–803. doi:10.1038/sj.onc.1201535. PMID 9362446

PMID 10949932. Oh JJ, West AR, Fishbein MC, Slamon DJ (2002). "A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3"

suggest that CDO1 (human cysteine dioxygenase type I) acts as a tumor suppressor gene and may potentially serve as a biomarker for cancer. Stipanuk MH

autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41. PMID 9500467

anchorage-independent growth. Hence, it has been proposed as a novel tumor suppressor gene. In colorectal cancer cells, RPRML is a target of Wnt/β-catenin

"MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes".

Lo KW, Welch WR, Berkowitz RS, Mok SC (April 2006). "Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and

CHEK1, a protein kinase that is encoded by the CHEK1 gene CHEK2, a tumor suppressor gene that encodes the CHK2 kinase This disambiguation page lists articles

and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants

as the sole tumor suppressor gene in this region. These genetic data suggest that CUX1 may be a haploinsufficient tumor suppressor gene. In addition

Shepard has made seminal contributions to gene therapy of cancer, to tumor suppressor gene targeted small molecule therapeutics, and to drugs which target

of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells". Biochem. Biophys

Meth JL, von Klitzing C, et al. (2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21):

"Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer

agents decrease the amount of cellular DNA methylation, allowing for tumor suppressor gene expression. DNA methyltransferase Garcia-Manero G (November 2008)

PMID 15489334. Liang H, Samanta S, Nagarajan L (2005). "SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells"

is believed to be a target of transcriptional suppression by the tumor suppressor gene WT1. Pax 2 is a transcription factor controlled by the signaling

Gunduz M, Ouchida M, et al. (2006). "Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and

"Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5

been thought that mutations in the retinoblastoma gene, the first tumor suppressor gene to be discovered, would be limited to the rare eye cancer retinoblastoma

Hirohashi S, Ohki M, Inazawa J (Dec 2005). "ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion

in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9". Oncogene. 26 (1): 148–57. doi:10.1038/sj.onc.1209767

was a member of the international team that discovered PTC1, a tumor suppressor gene that plays a critical role in the development of hereditary and

homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene". Cell. 68 (4): 621–2. doi:10.1016/0092-8674(92)90136-Z. PMID 1310897

a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product". Cancer Res. 56 (13): 2881–5. PMID 8674032. Min JH, Yang

homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene". Cell. 68 (4): 621–2. doi:10.1016/0092-8674(92)90136-Z. PMID 1310897

(February 2008). "The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers". J. Clin. Invest. 118 (2): 640–50. doi:10

Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics. 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110

generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation

unknown, however, Gelbard et al. studied 12 oncogenes or known tumor suppressor gene “hotspots” where mutations in these regions are known to cause other

generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation

postdoc, he started to study Wilms' tumor and characterized the tumor suppressor gene WT1 and WTX. In 2003, he recognized that certain patients with lung

Coignet LJ, Lingen MW (Jan 2006). "NOL7 is a nucleolar candidate tumor suppressor gene in cervical cancer that modulates the angiogenic phenotype". Oncogene

M, et al. (2006). "Identification of RASSF8 as a candidate lung tumor suppressor gene". Oncogene. 25 (28): 3934–3938. doi:10.1038/sj.onc.1209422. PMID 16462760

fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the

identified as a key responsible for the oncogenic activity, reducing the tumor suppressor gene PTEN expression and activating AKT/mTOR pathway. This cluster might

inherited metabolic disorder MCC (gene), a candidate colorectal tumor suppressor gene Merkel cell carcinoma, a rare and aggressive cancer of the skin

Li–Fraumeni syndrome and malignant rhabdoid tumors. A mutation in the tumor suppressor gene TP53 is usually characterized in this disease. Choroid plexus carcinomas

proliferation or apoptosis, in accordance to its congruence with the TP53 tumor suppressor gene The Hp53int1 gene was found to have no paralogs. Using NCBI BLAST

fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the

"Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 (35): 5502–9. doi:10.1038/sj

J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell

"Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31". Nat Genet. 27 (4): 392–8. doi:10.1038/86891

protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31". Oncogene. 20 (47): 6946–54. doi:10.1038/sj

hydrolysis reactions. ADAM11 The ADAM11 gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region

Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG (2006). "Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient

"Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1". Mol. Cell. Biol

R, Bi M, Guo L, Lu SH (Mar 2003). "ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein

suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536. Gao B

suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536. Wiemann

Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer. 124 (4): 793–8. doi:10.1002/ijc

region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates". Genomics. 60 (2): 161–71. doi:10.1006/geno.1999.5911

deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene". Clinical Cancer Research. 11 (3): 1119–28. doi:10.1158/1078-0432

multiple mutations in different subsystems (an oncogene and a tumor suppressor gene) are the most effective at causing cancer. For example, a mutation

Loss of a tumor suppressor gene locus according to the two-hit model: In the first hit, the tumor suppressor gene on one of the two chromosomes is affected

PMID 15009212. Kashuba VI, Li J, Wang F, et al. (2004). "RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies". Proc. Natl. Acad.

(2001). "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22". Oncogene. 20 (31): 4169–79. doi:10.1038/sj

Schwarz LE, Rosenthal A, Scherneck S (May 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene

MW, Gutmann DH, Lal A (November 2008). "The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling

Yankovsky N (Dec 2003). "Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species-

characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence

intraepithelial carcinoma. Mutation is found in TP53 gene which is a tumor suppressor gene even in precursor lesion suggesting early involvement of this gene

a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product". Cancer Research. 56 (13): 2881–5. PMID 8674032. "GenAtlas

Katoh M (2003). "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26". Int. J. Oncol. 22 (5): 1155–9. doi:10

Yankovsky N (Dec 2003). "Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species-

White S, Heath JK, Arden K, Maruta H (Oct 2000). "p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted

chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065

is a protein that in humans is encoded by the PRDM2 gene. This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily

2006). "Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous

X, Yan T, Wang L, Torbenson MS, Cai J (Nov 2011). "ARID2: a new tumor suppressor gene in hepatocellular carcinoma". Oncotarget. 2 (11): 886–91. doi:10

(July 2002). "Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt

I.; Opazo, Juan C. (2016). "Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage"

Kuramochi M, Fukuhara H, Nobukuni T, et al. (2001). "TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer" (PDF). Nat. Genet. 27 (4):

2010). "Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer". Cancer Research. 70 (1): 367–77. doi:10

nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development

"Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31". Leukemia. 14 (12): 2128–34. doi:10.1038/sj.leu.2401935

"Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors". J. Cell Biol

S, et al. (2004). "A novel apoptotic pathway induced by the drs tumor suppressor gene". Oncogene. 23 (17): 2977–87. doi:10.1038/sj.onc.1207419. PMID 15021917

and chronic periodontitis. This is based on the high amounts of tumor suppressor gene p53 mutations and k-ras arginine mutations found in patients with

core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene". Epigenetics. 6 (12): 1444–53. doi:10.4161/epi.6.12.18492. PMC 3256333

"Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27". Oncogene. 20 (8):

and d isoforms are not. In these conditions, they regulate the tumor suppressor gene CDON. It has been shown that miR-181 targets the homeobox protein

genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the

Science. 2012-12-01. Retrieved 2021-09-20. "A newly discovered tumor suppressor gene affects melanoma survival". EurekAlert!. Retrieved 2021-09-20. "Yardena

Sutherland GR, Callen DF (2002). "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3"

Lavie O, Dong SM, Beller U, Sidransky D (August 2003). "The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix"

(Emet Prize Laureates, 2003). Rotter's research focuses on the p53 tumor suppressor gene (Weizmann Institute of Science, n.d.). Rotter and her team believe

includes loss of heterozygosity on the 17p chromosome. The p53 (a tumor suppressor gene in the normal population) genome on 17p in neurofibrosarcoma patients

immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15". The Journal of Cancer Research. 62:

Risinger JI, Gumbs C, et al. (June 1998). "Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias". Cancer Res. 58 (12): 2500–3. PMID 9635567

factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene". Cancer Res. 64 (1): 102–107. doi:10.1158/0008-5472.CAN-03-2622

rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A". The Journal of Biological Chemistry. 268 (7): 4580–3. doi:10

Grant JW, Kleihues P, Hegi ME (1995) Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas

factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010). GRCh38: Ensembl

anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG". Oncogene. 25 (56): 7373–80. doi:10.1038/sj.onc.1209732. PMID 16767159

PMID 12168954. Schott DR, Chang JN, Deng G, et al. (1994). "A candidate tumor suppressor gene in human breast cancers". Cancer Res. 54 (6): 1393–6. PMID 8137235

Cho YE, Kim SM, Kim JY, Lee S, Park JH (Oct 2007). "The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death". Cell Death Differ. 14

rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A". The Journal of Biological Chemistry. 268 (7): 4580–3. doi:10

Cho YE, Kim SM, Kim JY, Lee S, Park JH (Oct 2007). "The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death". Cell Death Differ. 14

Schweinfest C (March 1994). "Localization of a candidate colon tumor-suppressor gene (DRA) to 7q22-q31.1 by fluorescence in situ hybridization". Genomics

Zhang HY, Yao XB (September 2006). "Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription

Hirohashi S (Aug 1994). "Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation". Biochemical

identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi:10.1038/sj.onc.1205365

Cancer", Vogelstein, et al., suggested that colon cells lose the APC tumor suppressor gene and become a small polyp. Next, they suggested that k-Ras becomes

et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells". Oncol. Res. 12 (11–12): 491–500. doi:10

296.5569: 920-922. Yuan Zhu, et al. "Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma." Cancer

"Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70

gene (NF1) on chromosome 17. This loss of function mutation in the tumor suppressor gene can cause tumors on the nerves called neurofibromas. These appear

homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene". Cell. 68 (4): 621–2. doi:10.1016/0092-8674(92)90136-Z. PMID 1310897

that hypermethylate. The CCDB provides pertinent data as to which tumor-suppressor gene silences the gene expression of cervical cancer.[citation needed]

that DFNA5 is regulated by P53 strongly suggests that DFNA5 is a tumor suppressor gene. GRCh38: Ensembl release 89: ENSG00000105928 – Ensembl, May 2017

strong cross-talk between the pathways regulating cyclin B and the tumor suppressor gene p53. In general levels of p53 and cyclin B are negatively correlated

(2003). "Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas". Cancer

transforming activity. In mice, the gene is known as TPL2 and is a tumor-suppressor gene whose absence contributes to the development and progression of

BL, Walsh GL, Hong WK, Mao L (August 2000). "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers". Clinical Cancer

mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics. 53 (2): 184–90. doi:10.1006/geno

(August 2009). "miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1". Mol. Cancer Res. 7 (8): 1234–43. doi:10.1158/1541-7786.MCR-08-0507

M, Suzuki H, et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. 129 (1): 156–69.

activity is stimulated. WRNp also physically interacts with p53, a tumor suppressor gene that stops the formation of tumors and the progression of cancers

Dang CV (1997). "Genomic organization of human MXI1, a putative tumor suppressor gene". Genomics. 32 (3): 466–70. doi:10.1006/geno.1996.0144. PMID 8838813

(February 2011). "Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis". Oncogene. 30

promotes the polyubiquitination and subsequent degradation of the tumor suppressor gene p53, thereby enabling the immortalization of infected cells. Strains

Schuuring E, et al. (June 2013). "Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors"

K (2007). "Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response

coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene". International Journal of Cancer. 87 (6): 794–7. doi:10

Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase

PMID 16215635. Wu M, Huang C, Gan K, et al. (2006). "LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit

SA, Vandyke K, Kok C, To LB, Zannettino AC (2014). "SAMSN1 is a tumor suppressor gene in multiple myeloma". Neoplasia. 16 (7): 572–85. doi:10.1016/j.neo

Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Proc Natl

involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and

mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1". J Biol Chem. 273 (12): 6704–9. doi:10.1074/jbc.273.12.6704

cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics. 59 (3): 275–81. doi:10.1006/geno

PMID 9843584. Woods DF, Bryant PJ (August 1991). "The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate

apoptosis such as BCR/ABL, Bcl-2, Bax protein, and cytochrome C. The tumor suppressor gene p53 is also important in the cell cycle regulation of K562 cells

Phosphatase and tensin homolog (Pten) is originally identified as a tumor suppressor gene. Recent studies found that Pten also suppressed axon regeneration

of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs". Oncogene. 17 (26): 3479–91. doi:10.1038/sj

Phosphatase and tensin homolog (Pten) is originally identified as a tumor suppressor gene. Recent studies found that Pten also suppressed axon regeneration

(January 2011). "Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer". Cancer Research. 71 (2): 572–82. doi:10

Siraj AK, Hussain A, Bu R, Gutiérrez MI (February 2003). "The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid

Bronson R, Vande Woude GF (January 2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene. 26 (2): 269–76. doi:10.1038/sj.onc.1209790. PMID 16819504

Sukegawa J, Lee S, et al. (July 1995). "Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural

autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41. PMID 9500467

alpha's role during granulocyte differentiation and CEBPA's role as a tumor suppressor gene is critically important in the prognosis of acute myeloid leukemia

M, Bubendorf L, Srikantan V, et al. (2001). "ANX7, a candidate tumor suppressor gene for prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4575–80

"Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer". Cancer Letters. 202

environmental stress resistance. In mouse embryos Pax3 blocks the tumor suppressor gene p53, which is necessary for controlled proliferation and genomic

Reed RA, Malkina A, Boctor B, Slamon DJ (April 2006). "3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through

Seminal contribution to the establishment of the theory of the tumor suppressor gene in the mechanism of human carcinogenesis 2008 Anthony James Pawson

DNA. Deletions in tumor cells may represent the inactivation of a tumor suppressor gene, and may have diagnostic, prognostic, or therapeutic implications

hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations" (PDF). Hepatology. 47 (6): 1955–63. doi:10.1002/hep.22256

in a wide range of tissues. Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for TSC disease. TSC1 and TSC2 proteins form a physical

required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene". Oncogene. 30 (16): 1956–1962. doi:10.1038/onc.2010.568. PMC 3230933

"Cloning a calcium channel alpha2delta-3 subunit gene from a putative tumor suppressor gene region at chromosome 3p21.1 in conventional renal cell carcinoma"

involvement is typically limited to the kidneys WT1: The Wilms' tumor suppressor gene regulates the expression of many genes involved in kidney and urogenital

Grade 3 (the highest histologic grade), mutations are found in a tumor suppressor gene, commonly p53 or PTEN. In 20% of endometrial hyperplasias and 50%

involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. The tetraspanin

Familial Adenomatous Polyposis is caused by a deletion of the APC tumor suppressor gene on the long (q) arm of chromosome 5. This chromosomal change results

Business Journal. Retrieved 18 February 2014. "Common variant of p53 tumor suppressor gene linked to increased inflammatory responses". ScienceDaily. Retrieved

the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer". Int. J. Cancer. 106 (4): 505–9. doi:10.1002/ijc

exhibit an increased P53 expression likely due to a deficit in the tumor suppressor gene. These indications give the impression of a migrating limbus because

Colitti CV, Rock CO, Berkowitz RS (June 1998). "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer". Oncogene. 16 (18): 2381–7.

a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product". Cancer Res. 56 (13): 2881–5. PMID 8674032. Zhou MI, Wang

Cancer Institute of New Jersey, known for his discovery of the PALB2 tumor suppressor gene Marilyn Kozak, RWJMS Professor of Biochemistry, discoverer of the

carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the

"Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation". Genes, Chromosomes & Cancer.

Burgess WH, Linehan WM, Klausner RD (1997). "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the

replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene". Molecular and Cellular Biology. 23 (2): 493–509. doi:10.1128/mcb

1999). "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21". Genomics. 59 (1): 59–65. doi:10.1006/geno

bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma". Tumour Biology. 27 (4): 221–6. doi:10.1159/000093057

endothelial growth factor receptor) which leads to increased levels of tumor suppressor gene called PEG3. Other angiogenic growth factors that decorin inhibits

Giono LE, Kimmelman AC, et al. (December 2001). "KLF6, a candidate tumor suppressor gene mutated in prostate cancer". Science. 294 (5551): 2563–6. Bibcode:2001Sci

promotes S-phase entry. Fbw7 is known to be a haplo-insufficient tumor suppressor gene implicated in several sporadic carcinomas, for which one mutant

Mhashilkar AM, Yang XH, et al. (June 2002). "The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory

of Medicine. Yu X, Li Z, Chan MT, Wu WK (2015). "PAQR3: a novel tumor suppressor gene". American Journal of Cancer Research. 5 (9): 2562–2568. PMC 4633890

promotes S-phase entry. Fbw7 is known to be a haplo-insufficient tumor suppressor gene implicated in several sporadic carcinomas, for which one mutant

Mhashilkar AM, Yang XH, et al. (June 2002). "The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory

pancreatic cysts, but yields are variable, between 25-50%. VHL tumor suppressor gene mutations (associated with Von Hippel-Lindau disease) are associated

Ghee S, Hastie ND (December 1999). "Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein". The Journal of

deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene". Clinical Cancer Research. 11 (3): 1119–1128. doi:10.1158/1078-0432

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

Burgess WH, Linehan WM, Klausner RD (1997). "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the

1016/S0959-8049(00)00158-1. PMID 10959047. Nives Pećina-Šlaus (2003). "Tumor suppressor gene E-cadherin and its role in normal and malignant cells". Cancer Cell

be involved in carcinogenesis (the c-Ha-ras oncogene and the p53 tumor-suppressor gene). Also supporting this mechanism are observations of o-toluidine-induced

Nadji M, Lai S, Trapido E, Meng L (2002). "Mutations in the p53 tumor suppressor gene and early onset breast cancer". Cancer Biology & Therapy. 1 (1):

Y, et al. (2007). "Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression". Cancer

PMID 17961905. Kondo K, Kaelin WG (Mar 2001). "The von Hippel-Lindau tumor suppressor gene". Experimental Cell Research. 264 (1): 117–25. doi:10.1006/excr

menin.[citation needed] MEN1 follows Knudson’s “two-hit” model for tumor suppressor gene carcinogenesis (30). The first hit is a heterozygous MEN1 germline

methylation of HBA1's promoter. Another example is silencing of a tumor suppressor gene p15INK4b, also called CDKN2B, in acute lymphoblastic leukemia and

JH, Mihm MC (Oct 1996). "Cytokine, cell adhesion receptor, and tumor suppressor gene expression in vulvar squamous carcinoma: correlation with prominent

for the repressive effects of Keap1 on Nrf2. Keap1 is not only a tumor suppressor gene, but also a metastasis suppressor gene. Recently, several interesting

with inherited retinoblastoma have alterations in the RB1 gene, a tumor-suppressor gene, and are likely to develop soft-tissue sarcomas as they mature into

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

Shridhar R, Dai Q, et al. (2004). "Cystatin m: a novel candidate tumor suppressor gene for breast cancer". Cancer Res. 64 (19): 6957–64. doi:10.1158/0008-5472

Mutations in the human homologue of Drosophila patched (PTCH1), a tumor suppressor gene on chromosome 9, were identified as the underlying genetic event

and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene". Oncogene. 23 (22): 4037–40. doi:10.1038/sj.onc.1207502. hdl:10171/18813

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

"The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation". Science. 373 (6561): 1327–1335. Bibcode:2021Sci.

Wnt/β-catenin signal transduction pathway and could potentially serve as a tumor-suppressor gene in liver cancer. Interestingly, as many of the genes are mutated

complex formation that includes β-catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. Following phosphorylation of the N-terminal

Heizmann CW, Schäfer BW (October 1997). "Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation"

University of Arizona Thesis The influence of zinc status onp53 tumor suppressor gene expression and p53 target genes in human hepatoblastoma, bronchial

methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia". Nat. Genet. 37 (3): 265–74. doi:10.1038/ng1521

through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association

"The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator". The Journal of Biological

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

currently unknown. The gene has been found to interact with FAT3, a tumor suppressor gene, as well as INTS2 a gene that is involved in snRNA processing and

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

contains the hSNF5/INI1 gene that appears to function as a classic tumor suppressor gene. Most rhabdoid tumors have INI1 deletions whether they occur in

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

Matthew P. Scott has identified the human homolog PTCH1 as a key tumor suppressor gene for the Hedgehog signaling pathway and the causative gene for Nevoid

lesion in cancer-cells, even more frequent than gene mutations. Tumor suppressor gene silencing by CpG island promoter hypermethylation is supposed to

inhibit cellular adhesion. Inactivation of Von Hippel-Lindau (VHL) tumor-suppressor gene and hypoxia suppressed GPR56 in a renal cell carcinoma cell line

Matthew P. Scott has identified the human homolog PTCH1 as a key tumor suppressor gene for the Hedgehog signaling pathway and the causative gene for Nevoid

(July 2002). "Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt

with similar mutations as seen in melanomas,. Mutations in the tumor suppressor gene BAP1 occur in approximately 15% of clear cell renal cell carcinoma

the isolation of the first oncogene from human cancer and of a tumor suppressor gene whose loss of function promotes retinoblastoma. 1995 John W. Cahn

PEDF induces PPAR-gamma expression which in turn induces p53, a tumor suppressor gene involved in cell cycle regulation and apoptosis. Thrombospondin

1999). "Analysis of the RAD54 gene on chromosome 1p as a potential tumor-suppressor gene in parathyroid adenomas". International Journal of Cancer. 83 (1):

three gene products. The WRAP53 gene partially overlaps the p53 tumor suppressor gene in a head-to-head orientation. Transcripts of WRAP53 that overlap

reported. A significant number of individuals with mutations on the rb tumor suppressor gene have also developed the tumor. Such gene encodes for the protein

human cancer. For example, nearly 50% of somatic mutations of the tumor suppressor gene p53 in colorectal cancer are G:C to A:T transitions within CpG sites

human cancer. For example, nearly 50% of somatic mutations of the tumor suppressor gene p53 in colorectal cancer are G:C to A:T transitions within CpG sites

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

"Aflatoxin B1 induces the transversion of G→T in codon 249 of the p53 tumor suppressor gene in human hepatocytes". Proceedings of the National Academy of Sciences

growth of mammary epithelial cells. This gene is also a candidate tumor suppressor gene for human breast cancer. FABP3 is known to interact with TNNI3K

prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. The mouse cells, which appear the growth-arrested, were observed

knockout mice with mutated Nbs1 which were also null of the p53 tumor suppressor gene displayed tumor onset significantly earlier than their p53 wildtype

human cancer. For example, nearly 50% of somatic mutations of the tumor suppressor gene p53 in colorectal cancer are G:C to A:T transitions within CpG sites

targeted in numerous studies. The p63 gene is a homologue of the tumor suppressor gene p53, though this is not indicative that patients with EEC are more

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

negative regulator of cell proliferation, effectively making CDKN1C a tumor suppressor gene. CDKN1C also works during fetal development, preventing the fetus

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

location of the closest human homologue of the Drosophila discs large tumor suppressor gene". Genomics. 30 (3): 613–6. doi:10.1006/geno.1995.1286. PMID 8825652

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

(2018-02-20). Suzuki H (ed.). "Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells". PLOS ONE. 13 (2): e0193275. Bibcode:2018PLoSO

mutagenesis, where the random insertion of a gene interferes with the tumor suppressor gene or stimulates an oncogene. There is currently no approved gene therapy

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

The SKI proto-oncogene is located at a region close to the p73 tumor suppressor gene at the locus 1p36.3 locus of a gene, suggesting a similar function

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

(March 2008). "MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene". Oncogene. 27 (14): 1971–1980. doi:10.1038/sj.onc.1210839. PMC 2705285

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

translation, autophagy, and cell growth. Mutations in the PTEN tumor suppressor gene are the best known genetic deficiencies in cancer which affect mTOR

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

regulators of oncogenesis, PDRM12 represents an ideal candidate tumor suppressor gene for chronic myeloid leukaemia. GRCh38: Ensembl release 89: ENSG00000130711

lung-cancer gene to a region of chromosome 6, and showed that RGS17 is a tumor suppressor gene in this region that shows association with lung cancer risk in highly

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

proto-oncogenes, though the exact mechanism is unknown. Further, the tumor suppressor gene products retinoblastoma and p53 are inactivated by the phosphorylation

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

5q21.1, this mutation is the adenomatous polyposis coli (APC)— a tumor suppressor gene. It is a condition in which hundreds of polyps are found within

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

organism in which it functions. The cdc4 gene is a haplo-insufficient tumor suppressor gene. Knock-out of this gene in mice leads to an embryonic lethal phenotype

marker for the cancer. Notably, DUT expression is regulated by the tumor suppressor gene p53 in order to promote apoptosis of tumor cells.<pmid19015155/>

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

"The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator". The Journal of Biological

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

Zhu F, Guo C, Wang Q, Shi Y, Wang J, Chen Y, Zhang L (May 2013). "Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression

4049/jimmunol.165.8.4522. PMID 11035092. Frisch SM (May 2004). "E1A as a tumor suppressor gene: commentary re S. Madhusudan et al. A multicenter Phase I gene therapy

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

Yeo CJ, Hruban RH, Kern SE (January 1996). "DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1". Science. 271 (5247): 350–3. Bibcode:1996Sci

Mutations and loss of function of the Von Hippel-Lindau (VHL) tumor suppressor gene play a causal role in the pathogenesis of clear cell renal carcinomas

breast tumors was shown to be associated with mutations in the tumor suppressor gene TP53. After the discovery of the Icelandic BRCA2 founder mutation

superfamily generally consists of positive growth regulators, RIG is a tumor-suppressor gene. In contrast to Ras, RIG works as an inhibitor for cell growth,

Oricchio (born 1979), discovered that the protein EphA7 activates the tumor suppressor gene for patients with follicular lymphoma Emīlija Gudriniece (1920–2004)

bi-allelic inactivation of the TSC2 genes, consistent with the "two-hit" tumor suppressor gene model. The second hit event in LAM cells is often loss of the chromosomal

"hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing". The Journal of Clinical Investigation. 120 (8): 2920–30

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

Aflatoxins induce a spectrum of mutations, including in the p53 tumor suppressor gene, which is a mutation seen in many types of cancers. Mutation in

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

in this area have been implicated in leukemia and is home to a tumor suppressor gene that is modified or not present in most tumor gene expression, it's

studies, it appears that IGFBP-3 functions as a low-penetrance tumor suppressor gene. Dysregulation of IGFBP-3 has been implicated in many cancers. Downregulation

methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia". Nat. Genet. 37 (3): 265–74. doi:10.1038/ng1521

Scherneck S, Rosenthal A (December 2004). "ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2". Oncogene. 23 (57): 9295–302. doi:10

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

discovering a gene that causes normal cells to form tumors, and the first tumor suppressor gene David Weinberger, blogger, internet expert, and political consultant

C; Martignetti, J. A; Friedman, S. L (2001). "KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer". Science. 294 (5551): 2563–6. Bibcode:2001Sci

M, Zucca E, Inghirami G, Bertoni F (May 2015). "PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas". Leukemia & Lymphoma. 56 (5): 1223–1228

Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations". Journal of Biological Chemistry. 288 (46): 33387–33397

structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene". Gene. 282 (1–2): 207–14. doi:10.1016/S0378-1119(01)00825-3. PMID 11814693

individuals with PACB were the PIK3CA gene in 12, PTEN tumor suppressor gene in 6, and TP53 tumor suppressor gene in 5 individuals. Less commonly, these cells had

mutations can survive. Phosphatase and tensin homolog (PTEN), another tumor suppressor gene, is itself lost or mutated. Epidermal growth factor receptor, a

imposes an increased risk of breast and ovarian cancer. TP53 – A tumor suppressor gene that is mutated in High grade serous carcinoma. RRSO – Risk reduction

"Mutational analysis of a dominant oncogene (c-Ki-ras-2) and a tumor suppressor gene (p53) in hamster lung tumorigenesis". Molecular Carcinogenesis.

further investigated and resulted in the first reported example of a tumor suppressor gene, RB. Juan Gundlach (1810–1896), naturalist, taxonomist Bartolomeu

normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function". Oncogene. 19 (48): 5435–43. doi:10.1038/sj.onc

induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors". Mutation Research

2004). "Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer". Oncogene. 23 (2): 395–402. doi:10.1038/sj

Paterlini-Bréchot P, Bréchot C. Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas. Hepatology, 30 : 677–681, 1999

H, Wang MB, Srivatsan ES (April 2012). "Cellular senescence and tumor suppressor gene p16". International Journal of Cancer. 130 (8): 1715–1725. doi:10

diseases. Evidence obtained in animals indicates that MYH9 acts as a tumor suppressor gene. Silencing of Myh9 in the epithelial cells in mice was associated

protein (CREB) identifies cysteine-rich protein 61 (CYR61) as a tumor suppressor gene in melanoma". J. Biol. Chem. 284 (38): 26194–26206. doi:10.1074/jbc

Chen M, Yang MH, Chang MM, Tyan YC, Chen YA (September 2019). "Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders

colorectal cancer. CEBPB: Involved in regulating immune responses EGR1: Tumor suppressor gene involved with neuronal plasticity and memory formation FOS: Proto-oncogene

patient. One of the most compelling examples is methylation of the tumor suppressor gene at promoter sequence that codes for MGMT. MGMT is a DNA repair protein

projects include the role of Ap3A bindings in the function of the FHIT tumor suppressor gene, characterization and inhibition of DNA methylation, and discovery

22–44 (abbreviated 1-q22-24); genomic alterations around the TP53 tumor suppressor gene at position 13.1 on the short or "p" arm of chromosome 17; genomic

genes, and a GpG island methylator phenotype (CIMP). CDKN2A is a tumor suppressor gene, while loss of its expression results in enhanced tumorigenesis

telomere length and contributes to cell immortality. Mutations in the tumor suppressor gene TP53 are seen in about 30% of cases of HCC. And mutations in Wnt

they infect, there will be always a chance of integrating into a tumor suppressor gene or an oncogene, leading to oncogenic transformation of the cell

PMID 11250690. Roth JA, Swisher SG, Meyn RE (October 1999). "p53 tumor suppressor gene therapy for cancer". Oncology. 13 (10 Suppl 5): 148–54. PMID 10550840

various malignancies. Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in colorectal

inhibitor 2B antisense RNA Regulation of tumour suppressor genes 12 VEZT/12q22 Vezatin, an adherens junction transmembrane protein Tumor suppressor gene

organism from potentially harmful cells.7 p53, also known as a tumor suppressor gene, is a major regulatory protein in the DNA damage response system