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Longer titles found: Proteasome (prosome, macropain) subunit, alpha 1 (view), Proteasome ATPase (view), Proteasome accessory factor E (view), Proteasome endopeptidase complex (view), Proteasome inhibitor (view), Immunoproteasome (view)

searching for Proteasome 270 found (821 total)

alternate case: proteasome

KIAA0368 (542 words) [view diff] exact match in snippet view article find links to article

Proteasome-associated protein ECM29 homolog is a protein that in humans is encoded by the KIAA0368 gene. GRCh38: Ensembl release 89: ENSG00000136813 -
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome (265 words) [view diff] exact match in snippet view article find links to article
associated with a deletion in the transcription gene POMP, which codes proteasome maturation protein. This prevents the correct formation of filaggrin from
POMP (555 words) [view diff] exact match in snippet view article find links to article
Proteasome maturation protein is a protein that in humans is encoded by the POMP gene. It is a short-lived maturation factor required for 20S proteasome
ATG7 (978 words) [view diff] exact match in snippet view article find links to article
degradation and its recycling. The sequence associates with the ubiquitin- proteasome system, UPS, required for the unique development of an autophagosomal
DNAJB2 (654 words) [view diff] exact match in snippet view article find links to article
neuronal shuttling factor for the sorting of chaperone clients to the proteasome". Curr. Biol. 15 (11): 1058–64. doi:10.1016/j.cub.2005.04.058. PMID 15936278
RAD23B (1,845 words) [view diff] exact match in snippet view article find links to article
N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic
RPN1 (815 words) [view diff] exact match in snippet view article find links to article
subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. The human version of this proteasome subunit is PSMD2
Ubiquitin bacterial (1,308 words) [view diff] exact match in snippet view article find links to article
Pup-proteasome system and a novel ORF-proteasome system that needed to be addressed and therefore was denoted UBact. The conjugation-proteasome components
Aggresome (1,481 words) [view diff] exact match in snippet view article find links to article
proteolytic degradation of the misfolded/damaged proteins involving ubiquitin–proteasome and autophagy–lysosome systems, and formation of detergent-insoluble aggresomes
Housekeeping gene (4,577 words) [view diff] exact match in snippet view article find links to article
NM_002792 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7), PSMB1 NM_002793 Homo sapiens proteasome (prosome, macropain) subunit
Ubiquitin carboxyl-terminal hydrolase L5 (667 words) [view diff] exact match in snippet view article find links to article
Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes". EMBO J. 25 (19): 4524–36. doi:10
Ubiquitin D (1,102 words) [view diff] exact match in snippet view article find links to article
U, Princiotta MF, Bennink JR, Krausslich HG, Yewdell JW (Nov 2000). "Proteasome inhibition interferes with gag polyprotein processing, release, and maturation
PSMG1 (481 words) [view diff] exact match in snippet view article find links to article
Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene. GRCh38: Ensembl release 89: ENSG00000183527 - Ensembl, May 2017
Jan Löwe (592 words) [view diff] exact match in snippet view article find links to article
Technische Universität München, for his thesis work on the structure of the proteasome completed at the Max Planck Institute of Biochemistry under the supervision
EIF3S6 (1,091 words) [view diff] exact match in snippet view article find links to article
Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/s0014-5793(02)03147-2. PMID 12220626
IFI35 (682 words) [view diff] exact match in snippet view article find links to article
associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". The Journal of Biological Chemistry.
Ataxin 3 (1,537 words) [view diff] exact match in snippet view article find links to article
valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis". Molecular
ID1 (1,952 words) [view diff] exact match in snippet view article find links to article
TK, Leung SC, Fung MK, Wang X, et al. (September 2008). "Id-1 induces proteasome-dependent degradation of the HBX protein". Journal of Molecular Biology
SHFM1 (832 words) [view diff] exact match in snippet view article find links to article
26S proteasome complex subunit DSS1 is a protein that in humans is encoded by the SHFM1 gene. The product of this gene has been localized within the split
CDC34 (1,325 words) [view diff] exact match in snippet view article find links to article
and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21
UBB+1 (311 words) [view diff] exact match in snippet view article find links to article
discovery it has been shown in vitro and in vivo that UBB+1 inhibits the proteasome and gives rise to downstream effects (e.g. a behavioral phenotype; impaired
KIF22 (1,069 words) [view diff] exact match in snippet view article find links to article
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj
RPS27A (924 words) [view diff] exact match in snippet view article find links to article
Kanayama H, Tanaka K, Aki M, et al. (1992). "Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells". Cancer Res. 51 (24):
PTBP1 (1,418 words) [view diff] exact match in snippet view article find links to article
requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This
SIAH2 (1,158 words) [view diff] exact match in snippet view article find links to article
family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin
COPS4 (902 words) [view diff] exact match in snippet view article find links to article
signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin
COPS8 (903 words) [view diff] exact match in snippet view article find links to article
signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin
UBE2I (2,840 words) [view diff] exact match in snippet view article find links to article
the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells". J. Biol. Chem. 273 (10): 5892–902
PAAF1 (486 words) [view diff] exact match in snippet view article find links to article
(May 2005). "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases". Molecular and Cellular
Von Hippel–Lindau tumor suppressor (3,187 words) [view diff] exact match in snippet view article find links to article
polyubiquitylation of HIF1A, ensuring that this protein will be degraded by the proteasome. In hypoxic conditions, HIF1A subunits accumulate and bind to HIFB. This
Neurodegeneration (6,416 words) [view diff] exact match in snippet view article find links to article
eukaryotic cells use to remove troublesome proteins or organelles: ubiquitin–proteasome: protein ubiquitin along with enzymes is key for the degradation of many
AnkB F-Box (187 words) [view diff] exact match in snippet view article find links to article
involved in the ubiquitination of proteins targeted for degradation by the proteasome. AnkB F-box is a protein that assembles host cell polyubiquitinated proteins
HERC3 (486 words) [view diff] exact match in snippet view article find links to article
and Rab5. Since HERC3 can itself be ubiquitinated and degraded by the proteasome, it likely has roles in both vesicular traffic and ubiquitin-dependent
ANAPC4 (774 words) [view diff] exact match in snippet view article find links to article
cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight
Salinosporamide (479 words) [view diff] exact match in snippet view article find links to article
Paul R.; Fenical, William (2003). "Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New
COPS6 (1,320 words) [view diff] exact match in snippet view article find links to article
signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin
MYO18B (505 words) [view diff] exact match in snippet view article find links to article
interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j
Jack Dixon (scientist) (456 words) [view diff] exact match in snippet view article
Dixon JE, Xu P, et al. Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function. Proceedings of the National Academy of Sciences
UBE2D3 (1,253 words) [view diff] exact match in snippet view article find links to article
spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation". The Biochemical Journal. 358 (Pt 1): 137–45. doi:10
KIF14 (577 words) [view diff] exact match in snippet view article find links to article
organization olfactory bulb development microtubule depolymerization proteasome-mediated ubiquitin-dependent protein catabolic process cerebellar Purkinje
UBE2A (1,045 words) [view diff] exact match in snippet view article find links to article
Matzuk MM (2003). "RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 550–5. Bibcode:2003PNAS
Daniela Stock (674 words) [view diff] exact match in snippet view article find links to article
Structure of 20S proteasome from yeast at 2.4 Å resolution (1997) Groll et al. Nature 386 (6624), 463 Crystal structure of the 20S proteasome from the archaeon
Nuclear bodies (1,579 words) [view diff] exact match in snippet view article find links to article
subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome". Molecular Biology of the Cell. 13 (8): 2771–82
TAP2 (1,199 words) [view diff] exact match in snippet view article find links to article
(1995). "Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines". Immunology. 83 (3):
Aaron Ciechanover (859 words) [view diff] exact match in snippet view article find links to article
Irwin Rose, of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and
C20orf27 (3,042 words) [view diff] exact match in snippet view article find links to article
(June 2000). "The proteasome activator 11 S REG or PA28: chimeras implicate carboxyl-terminal sequences in oligomerization and proteasome binding but not
Lung microbiota (1,671 words) [view diff] exact match in snippet view article find links to article
only polyubiquitinated (IκB-κ is targeted for degradation by the 26 S proteasome, allowing NF-κB translocation to the nucleus and activation the transcription
IκBα (1,505 words) [view diff] exact match in snippet view article find links to article
protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha". J. Biol. Chem. 273
COPS2 (1,247 words) [view diff] exact match in snippet view article find links to article
complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219
COP9 signalosome complex subunit 3 (993 words) [view diff] exact match in snippet view article find links to article
complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219
RHOBTB2 (720 words) [view diff] exact match in snippet view article find links to article
T, Hamaguchi M (2007). "DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation". Biochem. Biophys. Res. Commun. 360 (3):
TUBA8 (846 words) [view diff] exact match in snippet view article find links to article
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj
Delta-aminolevulinic acid dehydratase (1,915 words) [view diff] exact match in snippet view article find links to article
ion binding catalytic activity lyase activity identical protein binding proteasome core complex binding Cellular component cytosol extracellular exosome
ERCC8 (gene) (1,276 words) [view diff] exact match in snippet view article
O, et al. (2006). "CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne
Atrophy (873 words) [view diff] exact match in snippet view article find links to article
K+ channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway". FASEB J. 20 (9): 1531–3. doi:10.1096/fj.05-5350fje. PMID 16723379
AAA proteins (1,346 words) [view diff] exact match in snippet view article find links to article
luminal proteins are extracted from the ER and degraded in the cytosol by proteasomes. Substrate retrotranslocation and extraction is assisted by the Cdc48p(Ufd1p/Npl4p)
COPS7A (708 words) [view diff] exact match in snippet view article find links to article
complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219
FOXF2 (169 words) [view diff] exact match in snippet view article find links to article
development embryonic camera-type eye morphogenesis protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal
COP9 constitutive photomorphogenic homolog subunit 5 (1,395 words) [view diff] exact match in snippet view article find links to article
signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin
ALPL (1,545 words) [view diff] exact match in snippet view article find links to article
an Asp(289)→Val mutation fails to reach the cell surface and undergoes proteasome-mediated degradation". Journal of Biochemistry. 134 (1): 63–70. doi:10
SMURF1 (980 words) [view diff] exact match in snippet view article find links to article
via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi:10.1515/BC.2008.036. PMID 18208356
Sec61 alpha 1 (671 words) [view diff] exact match in snippet view article find links to article
transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469
Alpha-tubulin 3C (1,167 words) [view diff] exact match in snippet view article find links to article
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj
Selinexor (2,598 words) [view diff] exact match in snippet view article find links to article
resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal
Unfolded protein response (3,318 words) [view diff] exact match in snippet view article find links to article
the ubiquitin-proteasome pathway, as it is tagged by multiple ubiquitin molecules, targeting it for degradation by cytosolic proteasomes. Successful protein
TUBA1B (874 words) [view diff] exact match in snippet view article find links to article
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj
PTPN23 (505 words) [view diff] exact match in snippet view article find links to article
(2006). "The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation" (PDF). Front. Biosci. 11: 2138–43. doi:10.2741/1956. hdl:2434/18210
Gigaxonin (744 words) [view diff] exact match in snippet view article find links to article
folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway". Curr. Biol. 15 (22): 2050–5. doi:10.1016/j.cub.2005.10.052.
Insulin-degrading enzyme (2,373 words) [view diff] exact match in snippet view article find links to article
to several locations, including the cytosol, peroxisomes, endosomes, proteasome complexes, and the surface of cerebrovascular endothelial cells. Based
William J. Lennarz (1,342 words) [view diff] exact match in snippet view article find links to article
mouse PNGase Png1P to study the interaction of this protein with the proteasome. GST fusion proteins of each protein being observed in the study were
40S ribosomal protein S13 (1,001 words) [view diff] exact match in snippet view article find links to article
complementation to study the function of the Drosophila and human 26S proteasome subunit S13". Mol. Cell. Biol. 23 (15): 5320–30. doi:10.1128/MCB.23.15
GPS1 (910 words) [view diff] exact match in snippet view article find links to article
complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219
SMURF2 (1,315 words) [view diff] exact match in snippet view article find links to article
Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling"
Anne Bertolotti (1,272 words) [view diff] exact match in snippet view article find links to article
(2012-10-26). "Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition". Molecular Cell. 48 (2): 242–253. doi:10.1016/j.molcel.2012
UBE2R2 (488 words) [view diff] exact match in snippet view article find links to article
process protein K48-linked ubiquitination protein monoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination
40S ribosomal protein S7 (731 words) [view diff] exact match in snippet view article find links to article
2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J Biol Chem
SMURF2 (1,315 words) [view diff] exact match in snippet view article find links to article
Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling"
William J. Lennarz (1,342 words) [view diff] exact match in snippet view article find links to article
mouse PNGase Png1P to study the interaction of this protein with the proteasome. GST fusion proteins of each protein being observed in the study were
SLC25A46 (1,072 words) [view diff] exact match in snippet view article find links to article
(March 2017). "Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria". Molecular
UBE2H (710 words) [view diff] exact match in snippet view article find links to article
K48-linked ubiquitination ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein K11-linked
Nitric oxide synthase 2 (inducible) (612 words) [view diff] exact match in snippet view article
2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A
Leucine (3,817 words) [view diff] exact match in snippet view article find links to article
4]. Additionally, HMB may have antagonistic effects on the ubiquitin–proteasome pathway, a system that degrades intracellular proteins [5, 6]. Evidence
Irwin Rose (767 words) [view diff] exact match in snippet view article find links to article
died in 2016. Rose, I (11 August 2005). "Early work on the ubiquitin proteasome system, an interview with Irwin Rose". Cell Death & Differentiation. Springer
UBR1 (893 words) [view diff] exact match in snippet view article find links to article
transferase activity GO:0001948 protein binding Cellular component cytoplasm proteasome complex cytosol ubiquitin ligase complex Biological process negative regulation
BTRC (gene) (3,341 words) [view diff] exact match in snippet view article
Perrakis A, Medema RH, Freire R (October 2006). "Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery". Current
Sarah Tabrizi (2,862 words) [view diff] exact match in snippet view article find links to article
July 2011). "Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry". The EMBO Journal. 30 (15): 3065–3077
SKP2 (3,947 words) [view diff] exact match in snippet view article find links to article
each stage of the cell cycle due to periodic proteolysis; the ubiquitin-proteasome system mediates the degradation of these mitotic regulatory proteins,
Plasminogen activator (1,079 words) [view diff] exact match in snippet view article find links to article
hydrolase activity serine-type endopeptidase activity chaperone binding proteasome core complex binding protein antigen binding endopeptidase activity enzyme
Serum amyloid A (733 words) [view diff] exact match in snippet view article find links to article
sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition". Journal of Immunology. 174 (12): 8125–34. doi:10.4049/jimmunol
ZNF350 (739 words) [view diff] exact match in snippet view article find links to article
"Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage". Molecular and
COPS7B (625 words) [view diff] exact match in snippet view article find links to article
complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7
HNRNPLL (392 words) [view diff] exact match in snippet view article find links to article
"Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical
NDC80 (1,170 words) [view diff] exact match in snippet view article find links to article
(September 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". The Journal of Biological
Plitidepsin (603 words) [view diff] exact match in snippet view article find links to article
a proteasome inhibitor and an immunomodulator. It may be used after two prior lines of therapy if refractory and/or intolerant to both a proteasome inhibitor
RBX1 (1,510 words) [view diff] exact match in snippet view article find links to article
PM (Dec 1999). "Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1". Cellular and Molecular Biology
CUL1 (1,062 words) [view diff] exact match in snippet view article find links to article
and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001
NS2 (HCV) (1,152 words) [view diff] exact match in snippet view article
implication is that the carboxy-terminal domain – which is also home to the proteasome region of NS2 – are not important in particle production. This theory
MAPK12 (932 words) [view diff] exact match in snippet view article find links to article
"p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response". J. Biol
HLA-B associated transcript 3 (894 words) [view diff] exact match in snippet view article find links to article
protein binding polyubiquitin modification-dependent protein binding proteasome binding GO:0001948 protein binding ubiquitin-specific protease binding
RNF12 (678 words) [view diff] exact match in snippet view article find links to article
protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors
KAT5 (2,893 words) [view diff] exact match in snippet view article find links to article
Scheffner M, Khochbin S, Trouche D (Apr 2002). "Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation". The
NGLY1 (2,921 words) [view diff] exact match in snippet view article find links to article
putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway". Biochemical and Biophysical Research Communications. 287 (5):
NGLY1 (2,921 words) [view diff] exact match in snippet view article find links to article
putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway". Biochemical and Biophysical Research Communications. 287 (5):
USP5 (989 words) [view diff] exact match in snippet view article find links to article
(2002). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome"
UBE2G1 (684 words) [view diff] exact match in snippet view article find links to article
protein catabolic process protein ubiquitination protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
BRCC3 (813 words) [view diff] exact match in snippet view article find links to article
Deshaies RJ (Jan 2004). "JAMM: a metalloprotease-like zinc site in the proteasome and signalosome". PLoS Biology. 2 (1): E2. doi:10.1371/journal.pbio.0020002
P21 (3,907 words) [view diff] exact match in snippet view article find links to article
1021/bi00027a039. PMID 7612628. Almond JB, Cohen GM (April 2002). "The proteasome: a novel target for cancer chemotherapy". Leukemia. 16 (4): 433–43. doi:10
Bark isolate (166 words) [view diff] exact match in snippet view article find links to article
triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice". Cancer
CLCN3 (1,051 words) [view diff] exact match in snippet view article find links to article
nascent CFTR prevents its maturation and accelerates its degradation by the proteasome". EMBO J. 17 (23): 6879–87. doi:10.1093/emboj/17.23.6879. PMC 1171036
Cyclin (1,770 words) [view diff] exact match in snippet view article find links to article
fluctuations in cyclin gene expression and destruction by the ubiquitin mediated proteasome pathway, induce oscillations in Cdk activity to drive the cell cycle.
Chromosome 13 (1,538 words) [view diff] exact match in snippet view article find links to article
protein 2 NUPL1: encoding protein Nucleoporin p58/p45 POMP: encoding proteasome maturation protein PCCA: propionyl Coenzyme A carboxylase, alpha polypeptide
KHDRBS3 (1,258 words) [view diff] exact match in snippet view article find links to article
targets the alternative splicing factor T-STAR for degradation by the proteasome". Human Molecular Genetics. 13 (14): 1525–34. doi:10.1093/hmg/ddh165.
CEBPG (856 words) [view diff] exact match in snippet view article find links to article
et al. (2003). "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer". Oncogene. 22 (9): 1273–80. doi:10.1038/sj
Tom Maniatis (2,017 words) [view diff] exact match in snippet view article find links to article
others from the Harvard Medical School in 1994. The company invented the proteasome inhibitor Velcade (Bortezomid). ProScript was acquired by Millennium/Takeda
STUB1 (1,463 words) [view diff] exact match in snippet view article find links to article
ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling". Current Biology. 11 (20): 1569–77. doi:10.1016/S0960-9822(01)00487-0
Open reading frame (1,692 words) [view diff] exact match in snippet view article find links to article
J.; Payre, F.; Plaza, S. (2015). "Pri sORF peptides induce selective proteasome-mediated protein processing". Science. 349 (6254): 1356–1358. Bibcode:2015Sci
ID3 (gene) (1,262 words) [view diff] exact match in snippet view article
Dodds SG, Christy BA (1999). "Degradation of Id proteins by the ubiquitin-proteasome pathway". FASEB J. 13 (15): 2257–64. doi:10.1096/fasebj.13.15.2257. PMID 10593873
TBX21 (1,349 words) [view diff] exact match in snippet view article find links to article
by RNA polymerase II negative regulation of interleukin-2 production proteasome-mediated ubiquitin-dependent protein catabolic process regulation of T
ETV4 (1,069 words) [view diff] exact match in snippet view article find links to article
Totsuka Y, Kohgo T, Shindoh M (Feb 2005). "E1AF degradation by a ubiquitin-proteasome pathway". Biochemical and Biophysical Research Communications. 327 (2):
TUBA1A (1,798 words) [view diff] exact match in snippet view article find links to article
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj
Gal4 transcription factor (2,205 words) [view diff] exact match in snippet view article find links to article
transcription as are Tra1, TAF9, and SAGA/MED15 complex. A subunit of the 26 S proteasome Sug2 regulatory protein has a molecular and functional interaction with
BHLHB2 (1,124 words) [view diff] exact match in snippet view article find links to article
Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". The Journal of Biological Chemistry. 276 (18): 15306–15
KDELR1 (1,819 words) [view diff] exact match in snippet view article find links to article
of misfolded proteins. They also observed aggregates of the ubiquitin-proteasome system (a degradation system); this suggests that there was saturation
DNAJB6 (1,104 words) [view diff] exact match in snippet view article find links to article
with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells". Biology of Reproduction
N-myc-interactor (1,163 words) [view diff] exact match in snippet view article find links to article
associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10
WFS1 (1,186 words) [view diff] exact match in snippet view article find links to article
protein ligase binding calcium-dependent protein binding calmodulin binding proteasome binding Cellular component integral component of membrane endoplasmic
E1 (652 words) [view diff] exact match in snippet view article find links to article
ubiquitination reaction, which targets a protein for degradation via a proteasome] E1 regulatory sequence for the insulin gene Estrone, a hormone Pyruvate
ACVR1C (894 words) [view diff] exact match in snippet view article find links to article
S, Fu G, et al. (2008). "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like
Securin (562 words) [view diff] exact match in snippet view article find links to article
APCCdc20 complex ubiquitinates securin and targets it for degradation by 26S proteasome. This results in free separase that is able to destroy cohesin and initiate
Ileal sodium/bile acid cotransporter (1,025 words) [view diff] exact match in snippet view article find links to article
of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes". The Journal of Biological Chemistry. 279 (43):
Transaldolase deficiency (1,144 words) [view diff] exact match in snippet view article find links to article
formation of the protein. The deletion of Ser171 leads to inactivation and proteasome-mediated degradation of TALDO1. This shows the pentose phosphate pathway
Plasmin (1,547 words) [view diff] exact match in snippet view article find links to article
hydrolase activity serine-type endopeptidase activity chaperone binding proteasome core complex binding protein antigen binding endopeptidase activity enzyme
Transaldolase deficiency (1,144 words) [view diff] exact match in snippet view article find links to article
formation of the protein. The deletion of Ser171 leads to inactivation and proteasome-mediated degradation of TALDO1. This shows the pentose phosphate pathway
E2 (646 words) [view diff] exact match in snippet view article find links to article
E-2 may refer to: Ubiquitin-conjugating enzyme, a protein component of proteasome-mediated protein degradation E2 regulatory sequence for the insulin gene
ANKRD1 (4,275 words) [view diff] exact match in snippet view article find links to article
cardiomyocytes than endothelial cells; and CARP is degraded by the 26S proteasome via a PEST degron. In animal models of disease and injury, CARP has been
HHEX (1,510 words) [view diff] exact match in snippet view article find links to article
2003). "The transcriptional repressor protein PRH interacts with the proteasome". The Biochemical Journal. 374 (Pt 3): 667–75. doi:10.1042/BJ20030769
Robert Huber (1,211 words) [view diff] exact match in snippet view article find links to article
D; Bochtler, M; Bartunik, H. D.; Huber, R (1997). "Structure of 20S proteasome from yeast at 2.4 a resolution". Nature. 386 (6624): 463–71. Bibcode:1997Natur
Max Planck Institute of Biochemistry (654 words) [view diff] exact match in snippet view article find links to article
Machines and Signaling (Brenda Schulman / Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Proteins) Cellular and Molecular Biophysics (Petra
B-cell maturation antigen (1,522 words) [view diff] exact match in snippet view article find links to article
cell therapy directed against BCMA in myeloma patients refractory to a proteasome inhibitor or immunomodulatory drug, and who had received an anti-CD38
Daratumumab (1,531 words) [view diff] exact match in snippet view article find links to article
relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease
KCTD13 (370 words) [view diff] exact match in snippet view article find links to article
homooligomerization cell migration protein ubiquitination stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation
Eukaryotic translation initiation factor 4 gamma 1 (1,635 words) [view diff] exact match in snippet view article find links to article
Schneider RJ (Apr 1999). "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway". Science. 284 (5413): 499–502. doi:10.1126/science.284.5413.499
IRF3 (1,480 words) [view diff] exact match in snippet view article find links to article
Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation". Mol. Cell. Biol. 18 (5): 2986–96. doi:10.1128/MCB
Chromosome 21 (2,026 words) [view diff] exact match in snippet view article find links to article
centrosomal pericentrin PDXK: encoding enzyme Pyridoxal kinase PSMG1: Proteasome assembly chaperone 1 RNR4: RNA, ribosomal 45S cluster 4 RRP1: encoding
ARNTL (4,946 words) [view diff] exact match in snippet view article find links to article
(CK1 ε or CK1 δ), targeting these proteins for degradation by the 26S proteasome. The TTFL loop of nocturnal mice transcription levels of the Bmal1 gene
Cyclin-dependent kinase 9 (1,391 words) [view diff] exact match in snippet view article find links to article
and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001
PRPF19 (896 words) [view diff] exact match in snippet view article find links to article
"Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome". Biochem. J. 388 (Pt 2): 593–603. doi:10.1042/BJ20041517. PMC 1138967
SEC61B (902 words) [view diff] exact match in snippet view article find links to article
transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469
Said Sebti (927 words) [view diff] exact match in snippet view article find links to article
development of the drug now called PTX-100. The proteasome. In 2009 the Sebti lab discovered a new proteasome inhibitor called PI-083 Prescient Therapeutics
UBE2B (964 words) [view diff] exact match in snippet view article find links to article
pathway synaptonemal complex organization response to UV response to drug proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination
DNA damage-inducible transcript 3 (5,471 words) [view diff] exact match in snippet view article find links to article
"Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells". Endocrinology. 148 (7): 3258–70.
Manas Kumar Santra (560 words) [view diff] exact match in snippet view article find links to article
Labile Cholesterol Tethered MG132 Nanoparticle for Targeting Ubiquitin-Proteasome System in Cancer". ChemistrySelect. 1 (16): 5099–5106. doi:10.1002/slct
Caveolin 1 (1,549 words) [view diff] exact match in snippet view article find links to article
2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proceedings of the National Academy
HLA-DR3 (673 words) [view diff] exact match in snippet view article find links to article
Ja; Gough, Sc (Jul 1999). "Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium
Rosenthal fiber (244 words) [view diff] exact match in snippet view article find links to article
protein 27, protein beta-1), ubiquitin, vimentin, plectin, c-Jun, the 20 S proteasome, and synemin. Wippold FJ, Perry A, Lennerz J (May 2006). "Neuropathology
X-linked spinal muscular atrophy type 2 (1,604 words) [view diff] exact match in snippet view article find links to article
neurodegenerative disorders associated with defects in the ubiquitin-proteasome pathway. The severity of SMAX2 does not waiver regardless of the type
HIF1A (6,305 words) [view diff] exact match in snippet view article find links to article
(June 2001). "Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7". FEBS Letters. 498 (1): 62–6. doi:10.1016/S0014-5793(01)02499-1
Retinoic acid receptor gamma (1,195 words) [view diff] exact match in snippet view article find links to article
Voorhees JJ, Fisher GJ (Mar 2002). "Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT
Respiratory complex I (6,171 words) [view diff] exact match in snippet view article find links to article
disease is unclear, it is likely that mitochondrial dysfunction, along with proteasome inhibition and environmental toxins, may play a large role. In fact, the
UBE2D2 (1,289 words) [view diff] exact match in snippet view article find links to article
for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome". Molecular and Cellular Biology. 20 (13): 4691–8. doi:10.1128/MCB.20
Siddhartha Mukherjee (4,484 words) [view diff] exact match in snippet view article find links to article
behavior of normal stem cells, as well as cancer cells. Two such chemicals – proteasome inhibitors and activin inhibitors – are under clinical trials. Mukerjee's
GSK3A (485 words) [view diff] exact match in snippet view article find links to article
of peptidyl-serine phosphorylation cellular response to interleukin-3 proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation
TAP1 (1,200 words) [view diff] exact match in snippet view article find links to article
A, Trowsdale J (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing"
3C-like protease (1,674 words) [view diff] exact match in snippet view article find links to article
"Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors". ACS Medicinal Chemistry Letters. 10 (7): 1086–1092. doi:10
RFWD2 (557 words) [view diff] exact match in snippet view article find links to article
ubiquitin-dependent protein catabolic process post-translational protein modification proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
Tetherin (2,370 words) [view diff] exact match in snippet view article find links to article
tetherin. Sendai virus proteins HN and F direct tethrin to endosomes or proteasome for degradation. CHIKV protein nsP1 interacts with tetherin by disrupting
TSC2 (1,836 words) [view diff] exact match in snippet view article find links to article
Tuberin, therefore preventing its ubiquitination and degradation in the proteasome. Alternative splicing results in multiple transcript variants encoding
UBE3C (419 words) [view diff] exact match in snippet view article find links to article
ligase activity ubiquitin conjugating enzyme activity Cellular component proteasome complex intracellular anatomical structure nucleus cytoplasm Biological
Sodium diethyldithiocarbamate (402 words) [view diff] exact match in snippet view article find links to article
Dictionary Cvek B, Dvorak Z (2007). "Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals". Curr. Pharm. Des. 13 (30):
BRICHOS family (273 words) [view diff] exact match in snippet view article find links to article
protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation". Am. J. Respir. Cell Mol. Biol
HLA-DMA (996 words) [view diff] exact match in snippet view article find links to article
Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (Nov 1991). "Second proteasome-related gene in the human MHC class II region". Nature. 353 (6345): 667–8
TBCB (504 words) [view diff] exact match in snippet view article find links to article
folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway". Curr. Biol. 15 (22): 2050–5. doi:10.1016/j.cub.2005.10.052.
CXCR4 (2,639 words) [view diff] exact match in snippet view article find links to article
in targeting ubiquitylated proteins for degradation via the ubiquitin proteasome system. Evidence in numerous animal models suggests ubiquitin is anti-inflammatory
EGR1 (1,482 words) [view diff] exact match in snippet view article find links to article
et al. (October 2002). "Regulation of Egr-1 by association with the proteasome component C8". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
CDKN1B (5,124 words) [view diff] exact match in snippet view article find links to article
Fiorentino M, Draetta GF, Jessup JM, Pagano M (February 1997). "Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in
PLK4 (2,205 words) [view diff] exact match in snippet view article find links to article
Autophosphorylation of PLK4 results in ubiquitination and subsequent destruction by the proteasome. PLK4 has been shown to interact with Stratifin. GRCh38: Ensembl release
PTPRF (1,443 words) [view diff] exact match in snippet view article find links to article
Neckers LM (Feb 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin
TRIM11 (465 words) [view diff] exact match in snippet view article find links to article
the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066
NREP (353 words) [view diff] exact match in snippet view article find links to article
expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system". The Journal of Biological Chemistry. 275 (6): 4215–9. doi:10
HES7 gene (2,152 words) [view diff] exact match in snippet view article find links to article
for the somite segmentation clock. The cyclic nature of HES7 relies on proteasome-mediated degradation. Each cycle of HES7 expression coincides with the
Pulse-chase analysis (405 words) [view diff] exact match in snippet view article find links to article
2006). "Glycine-alanine repeats impair proper substrate unfolding by the proteasome". EMBO J. 25 (8): 1720–9. doi:10.1038/sj.emboj.7601058. PMC 1440830. PMID 16601692
Phytoplasma (5,232 words) [view diff] exact match in snippet view article find links to article
degradation in a ubiquitin/proteasome-dependent manner that, at least for SAP54, is dependent on interactions with the proteasome shuttle factor RAD23. Interestingly
TRIM9 (494 words) [view diff] exact match in snippet view article find links to article
negative regulation of SNARE complex assembly synaptic vesicle exocytosis proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
Activating transcription factor 2 (2,250 words) [view diff] exact match in snippet view article find links to article
the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells". J. Biol. Chem. 273 (10): 5892–902
DDB1 (1,400 words) [view diff] exact match in snippet view article find links to article
nucleotide-excision repair, DNA incision UV-damage excision repair DNA repair proteasome-mediated ubiquitin-dependent protein catabolic process DNA damage response
Constitutive androstane receptor (2,229 words) [view diff] exact match in snippet view article find links to article
PMID 8020947. Choi HS, Seol W, Moore DD (Jan 1996). "A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily". The
ARHGEF9 (500 words) [view diff] exact match in snippet view article find links to article
via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi:10.1515/BC.2008.036. PMID 18208356
Satoshi Ōmura (1,782 words) [view diff] exact match in snippet view article find links to article
well as: a specific inhibitor of protein kinase named staurosporine; a proteasome inhibitor named lactacystin; a fatty acid biosynthesis inhibitor named
Jan-Michael Peters (811 words) [view diff] exact match in snippet view article find links to article
studies, Peters discovered p97-ATPase and first characterized the 26S proteasome. Between 1992 and 1993, Peters continued working with Werner W. Franke
ZNF364 (368 words) [view diff] exact match in snippet view article find links to article
epidermal growth factor receptor signaling pathway protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination
C1D (726 words) [view diff] exact match in snippet view article find links to article
PMID 16189514. S2CID 4427026. Rothbarth K, Stammer H, Werner D (2002). "Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing
Mothers against decapentaplegic homolog 2 (1,935 words) [view diff] exact match in snippet view article find links to article
Feng XH (November 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling"
ITCH (464 words) [view diff] exact match in snippet view article find links to article
protein K48-linked ubiquitination regulation of protein deubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process regulation of hematopoietic
ACO1 (642 words) [view diff] exact match in snippet view article find links to article
(Apr 2007). "Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway". Molecular and Cellular Biology. 27 (7): 2423–30. doi:10.1128/MCB
Von Willebrand factor type C domain (570 words) [view diff] exact match in snippet view article find links to article
as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes
RUNX2 (2,174 words) [view diff] exact match in snippet view article find links to article
inability to escape the cell cycle. Molecularly, It has been proposed that proteasome inhibition by MG132 can stabilize Runx2 protein levels in late G1 and
IFI27 (613 words) [view diff] exact match in snippet view article find links to article
signaling pathway regulation of protein export from nucleus apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process modulation by host
Sudip Chattopadhyay (1,056 words) [view diff] exact match in snippet view article find links to article
of Blue Light Signaling in Arabidopsis, Is Degraded in the Dark by a Proteasome-mediated Pathway Independent of COP1 and SPA1". Journal of Biological
Arrestin beta 1 (1,489 words) [view diff] exact match in snippet view article find links to article
of insulin secretion involved in cellular response to glucose stimulus proteasome-mediated ubiquitin-dependent protein catabolic process phototransduction
Antibody-drug conjugate (2,280 words) [view diff] exact match in snippet view article find links to article
has progressed despite prior treatment with an immunomodulatory agent, proteasome inhibitor and anti-CD38 antibody Blenrep Moxetumomab pasudotox AstraZeneca
TFAP2A (3,046 words) [view diff] exact match in snippet view article find links to article
factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer
GPX3 (1,438 words) [view diff] exact match in snippet view article find links to article
(December 2009). "Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells". Free Radical Biology & Medicine.
Vincenzo Cerundolo (1,144 words) [view diff] exact match in snippet view article find links to article
V.  1999. Generation of an Immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein. J Immunol
EDEM3 (465 words) [view diff] exact match in snippet view article find links to article
processing response to unfolded protein glycoprotein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process mannose trimming
Far-red (1,042 words) [view diff] exact match in snippet view article find links to article
to phytochrome interacting factors (PIF), and targets the PIFs to the proteasome for degradation. Exposed to a low R:FR environment, Pfr absorbs FR and
ABTB1 (449 words) [view diff] exact match in snippet view article find links to article
complex Biological process translational elongation protein biosynthesis proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis
John S. O'Neill (1,450 words) [view diff] exact match in snippet view article find links to article
peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells". Proceedings of the National Academy of Sciences.
NHLRC1 (458 words) [view diff] exact match in snippet view article find links to article
positive regulation of protein ubiquitination protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein
TXNL1 (500 words) [view diff] exact match in snippet view article find links to article
protein-disulfide reductase (NAD(P)) activity Cellular component cytoplasm proteasome complex nucleus cytosol Biological process cellular response to oxidative
HMG-CoA reductase (3,801 words) [view diff] exact match in snippet view article find links to article
regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system". Molecular Biology of the Cell. 23 (23): 4484–94. doi:10.1091/mbc
HLA-DOB (1,010 words) [view diff] exact match in snippet view article find links to article
Mockridge I, et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing"
Hyaluronidase (2,503 words) [view diff] exact match in snippet view article find links to article
received at least one prior line of therapy including lenalidomide and a proteasome inhibitor. The role of hyaluronidases in cancer has been historically
TOB2 (520 words) [view diff] exact match in snippet view article find links to article
"Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". Eur. J. Biochem. 269 (14): 3596–604. doi:10.1046/j.1432-1033
USP44 (470 words) [view diff] exact match in snippet view article find links to article
spindle assembly checkpoint ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis cell
Cyclin-dependent kinase 1 (2,883 words) [view diff] exact match in snippet view article find links to article
localization to kinetochore apoptotic process cell population proliferation proteasome-mediated ubiquitin-dependent protein catabolic process GO:0007067 mitotic
MAP3K1 (3,022 words) [view diff] exact match in snippet view article find links to article
TRAFs and scaffolding. D. Degradation of canonical Ubiquitin-TRAF3 by the proteasome, release of non-canonical Ubiquitin-TRAF2 and -MAP3Ks into the cytoplasm
Netrin 1 (926 words) [view diff] exact match in snippet view article find links to article
of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron". J. Neurochem. 95 (1): 1–8.
AZIN1 (555 words) [view diff] exact match in snippet view article find links to article
S, et al. (2000). "Degradation of ornithine decarboxylase by the 26S proteasome". Biochem. Biophys. Res. Commun. 267 (1): 1–6. doi:10.1006/bbrc.1999.1706
CSRP2 (576 words) [view diff] exact match in snippet view article find links to article
and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42
Sp1 transcription factor (3,370 words) [view diff] exact match in snippet view article find links to article
mediates degradation of estrogen receptor alpha through activation of proteasomes". Molecular and Cellular Biology. 23 (6): 1843–55. doi:10.1128/MCB.23
CSN3 (gene) (639 words) [view diff] exact match in snippet view article
Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. Netherlands. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2
XPB (1,984 words) [view diff] exact match in snippet view article find links to article
repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor". Nucleic Acids Res. 25 (12): 2274–83
CLSPN (1,003 words) [view diff] exact match in snippet view article find links to article
I, van Vugt MA, Smits VA, et al. (2006). "Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery". Curr. Biol
USP13 (453 words) [view diff] exact match in snippet view article find links to article
GO:1904454, GO:1904455 ubiquitin-like protein-specific protease activity proteasome binding peptidase activity ubiquitin binding GO:0001948 protein binding
PELI1 (507 words) [view diff] exact match in snippet view article find links to article
protein K48-linked ubiquitination interleukin-1-mediated signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation
RFFL (385 words) [view diff] exact match in snippet view article find links to article
transduction by p53 class mediator regulation of fibroblast migration proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process
SPSB1 (494 words) [view diff] exact match in snippet view article find links to article
post-translational protein modification ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
Doubletime (gene) (3,028 words) [view diff] exact match in snippet view article
SLIMB, and it is then targeted for degradation through the ubiquitin-proteasome pathway. Therefore, the phosphorylation of PER by DBT leads to a decrease
NPDC1 (615 words) [view diff] exact match in snippet view article find links to article
novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78
ABCB5 (1,848 words) [view diff] exact match in snippet view article find links to article
with antigen processing and P-glycoprotein interact with subunits of the proteasome". Molecular Immunology. 42 (1): 137–41. doi:10.1016/j.molimm.2004.07.005
CLOCK (3,299 words) [view diff] exact match in snippet view article find links to article
transduction positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process histone acetylation
Vesicular monoamine transporter 2 (1,864 words) [view diff] exact match in snippet view article find links to article
vesicular monoamine transporter type 2 promoter and requirement of 20 S proteasome subunits for transcriptional activity". J. Biol. Chem. 282 (23): 17069–77
FBXW2 (718 words) [view diff] exact match in snippet view article find links to article
Chang GD, Yao TP, Chen H (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc
Thimet oligopeptidase (1,963 words) [view diff] exact match in snippet view article find links to article
thaliana, the enzymes were more recently discovered as part of the 20S proteasome and SA-binding proteins. Different names have been used to identify this
RNF122 (440 words) [view diff] exact match in snippet view article find links to article
endoplasmic reticulum endomembrane system cytoplasm Biological process proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination
SEC61G (492 words) [view diff] exact match in snippet view article find links to article
transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469
UBA1 (2,373 words) [view diff] exact match in snippet view article find links to article
PMID 26919560. Tsukamoto S (2016). "Search for Inhibitors of the Ubiquitin-Proteasome System from Natural Sources for Cancer Therapy". Chemical & Pharmaceutical
GSK3B (1,770 words) [view diff] exact match in snippet view article find links to article
hippocampus development beta-catenin destruction complex disassembly proteasome-mediated ubiquitin-dependent protein catabolic process Wnt signaling pathway
RNF24 (335 words) [view diff] exact match in snippet view article find links to article
apparatus endomembrane system Biological process protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination
Herpes simplex virus (6,266 words) [view diff] exact match in snippet view article find links to article
pyrithione inhibits herpes simplex virus replication through interfering with proteasome function and NF-κB activation". Antiviral Research. 100 (1): 44–53. doi:10
NEDD4 (3,390 words) [view diff] exact match in snippet view article find links to article
transporters resulting in their subsequent endocytosis and degradation by the proteasome, including the epithelial sodium channel (ENaC), voltage-gated calcium
Autoinflammatory diseases (2,116 words) [view diff] exact match in snippet view article find links to article
(CANDLE), and dysfunction of proteasome. This syndrome is caused by mutation in the gene, which encodes subunit β type-8 of proteasome (PSMB8 gene). Due to this
TSC1 (2,424 words) [view diff] exact match in snippet view article find links to article
Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC
BTBD2 (760 words) [view diff] exact match in snippet view article find links to article
cytoplasm SCF ubiquitin ligase complex cytosol P-body Biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis
Phosphofructokinase 2 (4,227 words) [view diff] exact match in snippet view article find links to article
"Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation". FEBS
TNFAIP1 (488 words) [view diff] exact match in snippet view article find links to article
migration protein ubiquitination immune response stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process
SCNN1B (3,025 words) [view diff] exact match in snippet view article find links to article
cannot attach a ubiquitin to it. Consequently, proteolysis of ENaC by proteasome is inhibited and ENaC accumulates in the membrane leading to enhanced
CAND1 (953 words) [view diff] exact match in snippet view article find links to article
is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation". The Plant Cell. 16 (7): 1870–82. doi:10
Sulfolobus acidocaldarius (953 words) [view diff] exact match in snippet view article find links to article
Andela Šaric, Ann-Christin Lindås, Nicholas P. Robinson, Buzz Baum: “The proteasome controls ESCRT-III–mediated cell division in an archaeon”; In: Science;
MyoD (3,404 words) [view diff] exact match in snippet view article find links to article
SC, Fung MK, Wang X, Wong KF, Wong YC (September 2008). "Id-1 induces proteasome-dependent degradation of the HBX protein". J. Mol. Biol. 382 (1): 34–43
Janus kinase 2 (3,237 words) [view diff] exact match in snippet view article find links to article
Silvennoinen O (May 2002). "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with
RNF11 (915 words) [view diff] exact match in snippet view article find links to article
ubiquitin-dependent protein catabolic process protein autoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
FBXO2 (551 words) [view diff] exact match in snippet view article find links to article
herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS
Louis Ignarro (2,704 words) [view diff] exact match in snippet view article find links to article
10992-10996. 1996 JM Griscavage, S Wilk and LJ Ignarro. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages
Kufor–Rakeb syndrome (1,343 words) [view diff] exact match in snippet view article find links to article
causes mislocalization of ATP13A2 to the endoplasmic reticulum where the proteasome degrades it through the ER-associated degradation (ERAD) pathway. Heterozygous
Molluscum contagiosum virus (2,667 words) [view diff] exact match in snippet view article find links to article
(August 2013). "Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies"
MARCH6 (618 words) [view diff] exact match in snippet view article find links to article
endoplasmic reticulum mannose trimming ubiquitin-dependent ERAD pathway proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
Cereblon (1,115 words) [view diff] exact match in snippet view article find links to article
regulation of protein homodimerization activity protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation
Plant disease resistance (6,863 words) [view diff] exact match in snippet view article find links to article
Ewan, Richard; Lee, Jack; Nelis, Stuart (1 October 2012). "The ubiquitin-proteasome system: central modifier of plant signalling". New Phytologist. 196 (1):
ARFIP2 (673 words) [view diff] exact match in snippet view article find links to article
Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23): 22021–8. doi:10
USP8 (898 words) [view diff] exact match in snippet view article find links to article
with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells". Biology of Reproduction
OSTM1 (842 words) [view diff] exact match in snippet view article find links to article
involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator
SPRY2 (1,537 words) [view diff] exact match in snippet view article find links to article
Bar-Sagi D (February 2003). "hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl". Current Biology. 13 (4): 308–14. doi:10.1016/S0960-9822(03)00086-1
UBXD5 (645 words) [view diff] exact match in snippet view article find links to article
binding Cellular component cytoplasm cytoskeleton Biological process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo /
Vinyl sulfone (255 words) [view diff] exact match in snippet view article find links to article
Wiley-Interscience. p. 1475. Patterson, Cam; Cyr, Douglas M., eds. (2005). Ubiquitin-Proteasome Protocols. Springer Science & Business Media. p. PA7. ISBN 9781592598953
Dishevelled binding antagonist of beta catenin 1 (DACT1) (954 words) [view diff] exact match in snippet view article
Smad2/3 binding sites in its promoter region. Dact1 is degraded through the proteasome and is described as a Wnt activator, a Wnt suppressor, or alternately
Dally (gene) (825 words) [view diff] exact match in snippet view article
identify it and try to correct the mutation, or directly send it to a proteasome using ubiquitins and degrade it. Notwithstanding, there is another possible
Phospholipase A-2-activating protein (619 words) [view diff] exact match in snippet view article find links to article
process inflammatory response signal transduction ubiquitin recycling proteasome-mediated ubiquitin-dependent protein catabolic process macroautophagy
SNIP1 (598 words) [view diff] exact match in snippet view article find links to article
RH, Grasser WA, Paralkar V, Wang T (2002). "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic
Suppressor of cytokine signaling 1 (1,957 words) [view diff] exact match in snippet view article find links to article
Silvennoinen O (May 2002). "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with