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Longer titles found: Chromosome instability syndrome (view)

searching for Chromosome instability 35 found (61 total)

Ganesh Nagaraju (767 words) [view diff] exact match in snippet view article find links to article

damage responses in mammalian cells, and mechanisms underlying chromosome instability genetic diseases and cancer. The Department of Biotechnology of

Alan D'Andrea (866 words) [view diff] exact match in snippet view article find links to article

D'Andrea's research at the Dana Farber Cancer Institute focuses on chromosome instability and cancer susceptibility. He is currently the director of the Center

FANC proteins (1,066 words) [view diff] exact match in snippet view article find links to article

described in 1927 by Guido Fanconi, a Swiss pediatrician. It is a chromosome instability syndrome characterized by the progressiveness of bone marrow failure

EIF5A2 (792 words) [view diff] exact match in snippet view article find links to article

eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability". BMC Cancer. 11: 199. doi:10.1186/1471-2407-11-199. PMC 3118894

Ubiquitin D (2,244 words) [view diff] exact match in snippet view article find links to article

chromosome instability, apoptosis and immune response. UBD deregulation may induce abnormal alterations in apoptosis, cell division or chromosome instability

MECOM (4,864 words) [view diff] no match in snippet view article find links to article

MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain

DNMT3B (1,443 words) [view diff] exact match in snippet view article find links to article

Hulten M, Qu X, Russo JJ, Viegas-Péquignot E (November 1999). "Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase

Xin Lu (1,005 words) [view diff] exact match in snippet view article find links to article

transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?". Cell. 75 (4): 765–778. doi:10.1016/0092-8674(93)90496-d

Cyclin E1 (1,720 words) [view diff] exact match in snippet view article find links to article

of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found

SMC1B (1,394 words) [view diff] exact match in snippet view article find links to article

(October 2022). "Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line". Proceedings of the National Academy of Sciences

Centre for Gene Regulation and Expression (584 words) [view diff] exact match in snippet view article find links to article

human diseases such as cancer which are often characterised by chromosome instability. Wellcome Trust Wellcome Centre for Human Genetics Wellcome Trust

Stephen C. West (1,292 words) [view diff] case mismatch in snippet view article find links to article

Jena, Germany, and is currently on the SABs of the Center for Chromosome Instability, University of Copenhagen, Denmark, the China Medical University

USP9Y (1,018 words) [view diff] exact match in snippet view article find links to article

PMID 12508125. Richard SM, Knuutila S, Peltomäki P, et al. (2003). "Y chromosome instability in lymphoproliferative disorders". Mutat. Res. 525 (1–2): 103–7

Tumors of the hematopoietic and lymphoid tissues (2,329 words) [view diff] exact match in snippet view article find links to article

repair by an imprecise processes such as non-homologous end joining. Chromosome instability in chronic myeloid leukemia may be due to oxidative damage to DNA

Von Hippel–Lindau tumor suppressor (3,282 words) [view diff] exact match in snippet view article find links to article

Meraldi P, Trek W (2009). "VHL loss causes spindle disorientation and chromosome instability". Nature Cell Biology. 11 (8): 994–1001. doi:10.1038/ncb1912. PMID 19620968

POT1 (1,200 words) [view diff] exact match in snippet view article find links to article

protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Alternatively spliced transcript

Chung Hyung-min (676 words) [view diff] exact match in snippet view article find links to article

Park, SJ; Lim, JJ; Lee, HJ; Lee, SM; Chung, HM (2011). "Effect of chromosome instability on the maintenance and differentiation of human embryonic stem cells

NEK2 (1,182 words) [view diff] exact match in snippet view article find links to article

24081. PMID 9295362. Hayward DG, Fry AM (2006). "Nek2 kinase in chromosome instability and cancer". Cancer Lett. 237 (2): 155–66. doi:10.1016/j.canlet

Adenomatous polyposis coli (3,225 words) [view diff] exact match in snippet view article find links to article

lead to loss of β-catenin regulation, altered cell migration and chromosome instability. Rosenberg et al. found that APC directs cholinergic synapse assembly

Minichromosome maintenance (3,042 words) [view diff] exact match in snippet view article find links to article

BK, Schimenti JC (January 2007). "A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice". Nature Genetics. 39 (1): 93–8

MCT-1 (483 words) [view diff] exact match in snippet view article find links to article

"Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity". Mol. Cancer Res. 7 (4): 536–48. doi:10.1158/1541-7786

STAG3 (gene) (1,357 words) [view diff] exact match in snippet view article

Hieter P (March 2008). "Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers". Proceedings of the National Academy

2,6-Diaminopurine (1,394 words) [view diff] exact match in snippet view article find links to article

Henegariu, O; Liang, L; Stambrook, PJ; Tischfield, JA (20 June 2000). "Chromosome instability contributes to loss of heterozygosity in mice lacking p53". Proceedings

Telomerase (5,697 words) [view diff] exact match in snippet view article find links to article

has an activated telomerase, eliminating the process of death by chromosome instability or loss, absence of apoptosis-induction pathways, and continued

DNA polymerase beta (2,214 words) [view diff] exact match in snippet view article find links to article

A, et al. (June 2002). "Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis". Cancer Research. 62 (12): 3511–4. PMID 12067997

Anaphase lag (1,534 words) [view diff] exact match in snippet view article find links to article

adenocarcinoma of the lung. Those individuals with higher rates of chromosome instability were associated with worse 5-year survival curves. This was similarly

Chromoplexy (922 words) [view diff] exact match in snippet view article find links to article

31;361(6405):eaam8419. Pihan, G. a. (2013). Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer. Frontiers

MRN complex (3,079 words) [view diff] exact match in snippet view article find links to article

TO, Smogorzewska A, Pietrucha B, Weemaes C, Stewart GS (2019). "Chromosome instability syndromes". Nat Rev Dis Primers. 5 (1): 64. doi:10.1038/s41572-019-0113-0

Patient derived xenograft (3,596 words) [view diff] exact match in snippet view article find links to article

heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability". The Journal of Pathology. 208 (5): 643–652. doi:10.1002/path.1936

Subtelomere (2,822 words) [view diff] exact match in snippet view article find links to article

However, the use of inter-chromosomal circularization engenders chromosome instability by creating two centromeres in a single chromosome, causing chromosomal

Chromothripsis (3,134 words) [view diff] exact match in snippet view article find links to article

PMC 2922543. PMID 20663956. Rosin MP, German J (1985). "Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated

Telomeres in the cell cycle (2,640 words) [view diff] exact match in snippet view article find links to article

Bacchetti, S. (May 1992). "Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity"

Spindle checkpoint (9,145 words) [view diff] exact match in snippet view article find links to article

the proper chromosome segregation in each cell cycle preventing chromosome instability (CIN) also known as genome instability. Genomic integrity is now

Bik Kwoon Tye (2,058 words) [view diff] exact match in snippet view article find links to article

, Tye, B. K. & Schimenti, J. C. A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat Genet 39, 93-98, doi:10

Human somatic variation (3,219 words) [view diff] exact match in snippet view article find links to article

Vikkula, Miikka; Schuit, Frans; Fryns, Jean-Pierre (May 2002). "Chromosome instability is common in human cleavage-stage embryos" (PDF). Nature Medicine