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searching for Spindle checkpoint 41 found (71 total)

MAD2L1 (1,975 words) [view diff] exact match in snippet view article find links to article

domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15): 5190–9. doi:10.1128/MCB.21

Securin (562 words) [view diff] exact match in snippet view article find links to article

Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin,

CDC20 (3,307 words) [view diff] exact match in snippet view article find links to article

"p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene. 19 (40): 4557–62. doi:10.1038/sj.onc.1203803. ISSN 0950-9232

HORMA domain (202 words) [view diff] exact match in snippet view article find links to article

Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection

NDC80 (1,178 words) [view diff] exact match in snippet view article find links to article

microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation

MAD2L1BP (823 words) [view diff] exact match in snippet view article find links to article

arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached

CHEK1 (3,340 words) [view diff] exact match in snippet view article find links to article

mediated by regulatory proteins. Chk1 has a regulatory role in the spindle checkpoint however the relationship is less clear as compared to checkpoints

Aurora kinase B (4,535 words) [view diff] exact match in snippet view article find links to article

"Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis". Current Biology. 12

TAOK1 (753 words) [view diff] no match in snippet view article find links to article

"A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling". Nat. Cell Biol. 9 (5): 556–64. doi:10.1038/ncb1569. PMID 17417629

Dynactin (2,819 words) [view diff] exact match in snippet view article find links to article

binding between DCTN2/dynamitin and zw10 and has a role in mitotic spindle checkpoint inactivation. During prometaphase, dynactin also helps target polo-like

Andrea Musacchio (1,159 words) [view diff] exact match in snippet view article find links to article

complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint". The EMBO Journal. 21 (10): 2496–506. doi:10.1093/emboj/21.10.2496

NUF2 (945 words) [view diff] exact match in snippet view article find links to article

chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID 11685532

CDC16 (1,291 words) [view diff] exact match in snippet view article find links to article

Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is

CDC27 (1,868 words) [view diff] exact match in snippet view article find links to article

Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is

ZW10 (1,305 words) [view diff] exact match in snippet view article find links to article

required for chromosome motion and congression independent of the spindle checkpoint". Curr. Biol. 17 (11): 973–80. Bibcode:2007CBio...17..973Y. doi:10

Reversine (300 words) [view diff] exact match in snippet view article find links to article

"Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine". The Journal of Cell

TTK (gene) (835 words) [view diff] exact match in snippet view article

Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450

ERCC excision repair 6 like, spindle assembly checkpoint helicase (669 words) [view diff] exact match in snippet view article find links to article

centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint". Cell. 128 (1): 101–114. doi:10.1016/j.cell.2006.11.041. PMID 17218258

SPC24 (370 words) [view diff] no match in snippet view article find links to article

tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10

40S ribosomal protein S27 (1,369 words) [view diff] exact match in snippet view article find links to article

Martin-Lluesma S, Stucke VM, Nigg EA (Sep 2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science. 297

Survivin (780 words) [view diff] exact match in snippet view article find links to article

Marchisio PC, et al. (December 1998). "Control of apoptosis and mitotic spindle checkpoint by survivin". Nature. 396 (6711): 580–584. Bibcode:1998Natur.396.

Deubiquitinating enzyme (4,317 words) [view diff] exact match in snippet view article find links to article

See schematic of the role of DUBs in the cell cycle regulation. The spindle checkpoint (also referred to as the mitotic checkpoint) ensures proper separation

Aurora kinase C (1,969 words) [view diff] exact match in snippet view article find links to article

LY (March 2014). "Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B". Cell Death & Disease. 5

ZWINT (823 words) [view diff] exact match in snippet view article find links to article

and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene. 25 (52): 6901–14. doi:10.1038/sj.onc.1209687.

CDK5RAP2 (1,236 words) [view diff] exact match in snippet view article find links to article

of mitotic cell cycle microtubule bundle formation regulation of spindle checkpoint establishment of mitotic spindle orientation centriole replication

Shugoshin 1 (931 words) [view diff] exact match in snippet view article find links to article

on histone H2A of nucleosome, which is the important substrate of spindle checkpoint kinase BUB1. Centromeric cohesin and H2A-pT120 specify two distinct

MAD1L1 (644 words) [view diff] exact match in snippet view article find links to article

Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". The EMBO Journal. 20 (22): 6371–6382. doi:10.1093/emboj/20.22.6371

MAD2L2 (1,003 words) [view diff] exact match in snippet view article find links to article

Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–187. doi:10.1006/geno.1999.5831. PMID 10366450

NEK2 (1,182 words) [view diff] exact match in snippet view article find links to article

interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling". J. Biol. Chem. 279 (19): 20049–57. doi:10.1074/jbc.M314205200

Shugoshin N terminal protein domain (552 words) [view diff] exact match in snippet view article find links to article

the sister chromatids remaining tethered. Shugoshin also acts as a spindle checkpoint component. It senses tension between sister chromatids during mitosis

Von Hippel–Lindau tumor suppressor (3,599 words) [view diff] exact match in snippet view article find links to article

increases the concentration of MAD2, an important protein of the spindle checkpoint. Also, VHL colocalizes with the microtubule. Thus VHL loss leads to

APC/C activator protein CDH1 (1,553 words) [view diff] exact match in snippet view article find links to article

Furthermore, it is thought to be a possible target of a BUB2-dependent spindle checkpoint pathway. The anaphase-promoting complex/cyclosome (APC/c) is an ubiquitin

ChIP-on-chip (3,057 words) [view diff] exact match in snippet view article find links to article

chromatin assembly/condensation, chromosome segregation, and the mitotic spindle checkpoint Other applications for ChIP-on-chip include DNA replication, recombination

NDRG1 (2,179 words) [view diff] exact match in snippet view article find links to article

by p53 class mediator response to metal ion positive regulation of spindle checkpoint regulation of cell population proliferation cellular response to hypoxia

Makoto Furutani-Seiki (1,372 words) [view diff] exact match in snippet view article find links to article

Matsuura, Shinya (2011-05-15). "Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates". Human Molecular

Paclitaxel (6,401 words) [view diff] exact match in snippet view article find links to article

original on 12 February 2010. Bharadwaj R, Yu H (March 2004). "The spindle checkpoint, aneuploidy, and cancer". Oncogene. 23 (11): 2016–2027. doi:10.1038/sj

Hysteresis (9,125 words) [view diff] exact match in snippet view article find links to article

three designated checkpoints to account for this: G1/S, G2/M, and the spindle checkpoint. Irreversible hysteresis in this context ensures that once a cell

SKA2 (1,492 words) [view diff] exact match in snippet view article find links to article

regulates the maintenance of the metaphase plate and silencing of the spindle checkpoint leading to the onset of anaphase during mitosis. SKA2 also interacts

Cyclin B3 (1,701 words) [view diff] exact match in snippet view article find links to article

required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation". PLoS Genetics

Condensin (9,739 words) [view diff] exact match in snippet view article find links to article

negative regulator. For condensin II, involvement of Polo and the spindle checkpoint kinase Mps1 has been suggested. It has been reported that the CAP-H2

Induced cell cycle arrest (3,291 words) [view diff] exact match in snippet view article find links to article

dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy". Cell Cycle. 4 (10): 1385–8. doi:10.4161/cc