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searching for Spindle checkpoint 39 found (66 total)

alternate case: spindle checkpoint

MAD2L1 (1,967 words) [view diff] exact match in snippet view article find links to article

domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15): 5190–9. doi:10.1128/MCB.21
Securin (562 words) [view diff] exact match in snippet view article find links to article
Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin,
CDC20 (3,290 words) [view diff] exact match in snippet view article find links to article
"p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene. 19 (40): 4557–62. doi:10.1038/sj.onc.1203803. ISSN 0950-9232
HORMA domain (202 words) [view diff] exact match in snippet view article find links to article
Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection
NDC80 (1,170 words) [view diff] exact match in snippet view article find links to article
microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation
MAD2L1BP (823 words) [view diff] exact match in snippet view article find links to article
arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached
CHEK1 (3,416 words) [view diff] exact match in snippet view article find links to article
mediated by regulatory proteins. Chk1 has a regulatory role in the spindle checkpoint however the relationship is less clear as compared to checkpoints
Aurora B kinase (4,670 words) [view diff] exact match in snippet view article find links to article
"Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis". Current Biology. 12
TAOK1 (727 words) [view diff] no match in snippet view article find links to article
"A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling". Nat. Cell Biol. 9 (5): 556–64. doi:10.1038/ncb1569. PMID 17417629
Dynactin (2,848 words) [view diff] exact match in snippet view article find links to article
binding between DCTN2/dynamitin and zw10 and has a role in mitotic spindle checkpoint inactivation. During prometaphase, dynactin also helps target polo-like
Andrea Musacchio (1,133 words) [view diff] exact match in snippet view article find links to article
complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint". The EMBO Journal. 21 (10): 2496–506. doi:10.1093/emboj/21.10.2496
NUF2 (938 words) [view diff] exact match in snippet view article find links to article
chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID 11685532
ZW10 (1,258 words) [view diff] exact match in snippet view article find links to article
required for chromosome motion and congression independent of the spindle checkpoint". Curr. Biol. 17 (11): 973–80. doi:10.1016/j.cub.2007.04.056. PMC 2570756
CDC16 (1,296 words) [view diff] exact match in snippet view article find links to article
Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is
ERCC excision repair 6 like, spindle assembly checkpoint helicase (661 words) [view diff] exact match in snippet view article find links to article
centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint". Cell. 128 (1): 101–114. doi:10.1016/j.cell.2006.11.041. PMID 17218258
CDC27 (1,871 words) [view diff] exact match in snippet view article find links to article
Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is
TTK (gene) (814 words) [view diff] exact match in snippet view article
Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450
SPC24 (370 words) [view diff] no match in snippet view article find links to article
tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10
Reversine (300 words) [view diff] exact match in snippet view article find links to article
"Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine". The Journal of Cell
40S ribosomal protein S27 (1,348 words) [view diff] exact match in snippet view article find links to article
Martin-Lluesma S, Stucke VM, Nigg EA (Sep 2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science. 297
Conly Rieder (1,152 words) [view diff] exact match in snippet view article find links to article
required for chromosome motion and congression independent of the spindle checkpoint. Current Biology 17:973-980. Ban, K.H., J.Z. Torres, J. J. Miller
AURKC (2,008 words) [view diff] exact match in snippet view article find links to article
LY (March 2014). "Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B". Cell Death & Disease. 5
MAD1L1 (513 words) [view diff] exact match in snippet view article find links to article
Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. 20 (22): 6371–82. doi:10.1093/emboj/20.22.6371. PMC 125308
Deubiquitinating enzyme (4,258 words) [view diff] exact match in snippet view article find links to article
See schematic of the role of DUBs in the cell cycle regulation. The spindle checkpoint (also referred to as the mitotic checkpoint) ensures proper separation
ZWINT (814 words) [view diff] exact match in snippet view article find links to article
and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene. 25 (52): 6901–14. doi:10.1038/sj.onc.1209687.
CDK5RAP2 (1,236 words) [view diff] exact match in snippet view article find links to article
mitotic cell cycle • microtubule bundle formation • regulation of spindle checkpoint • establishment of mitotic spindle orientation • centriole replication
MAD2L2 (1,001 words) [view diff] exact match in snippet view article find links to article
Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–187. doi:10.1006/geno.1999.5831. PMID 10366450
NEK2 (1,172 words) [view diff] exact match in snippet view article find links to article
interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling". J. Biol. Chem. 279 (19): 20049–57. doi:10.1074/jbc.M314205200
Fisetin (1,959 words) [view diff] exact match in snippet view article find links to article
fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint". Carcinogenesis. 30 (6): 1032–1040. doi:10.1093/carcin/bgp101. PMC 2691139
Shugoshin N terminal protein domain (552 words) [view diff] exact match in snippet view article find links to article
the sister chromatids remaining tethered. Shugoshin also acts as a spindle checkpoint component. It senses tension between sister chromatids during mitosis
SGOL1 (1,226 words) [view diff] exact match in snippet view article find links to article
on histone H2A of nucleosome, which is the important substrate of spindle checkpoint kinase BUB1. Centromeric cohesin and H2A-pT120 specify two distinct
Von Hippel–Lindau tumor suppressor (3,187 words) [view diff] exact match in snippet view article find links to article
increases the concentration of MAD2, an important protein of the spindle checkpoint. Thus VHL-loss leads to a weakened checkpoint and subsequently chromosome
APC/C activator protein CDH1 (1,569 words) [view diff] exact match in snippet view article find links to article
Furthermore, it is thought to be a possible target of a BUB2-dependent spindle checkpoint pathway. The anaphase-promoting complex/cyclosome (APC/c) is an ubiquitin
NDRG1 (2,175 words) [view diff] exact match in snippet view article find links to article
p53 class mediator • response to metal ion • positive regulation of spindle checkpoint • regulation of cell population proliferation • cellular response
Paclitaxel (5,943 words) [view diff] exact match in snippet view article find links to article
09/01/2008. Accessed 10-2-21. Bharadwaj R, Yu H (March 2004). "The spindle checkpoint, aneuploidy, and cancer". Oncogene. 23 (11): 2016–27. doi:10.1038/sj
ChIP-on-chip (2,938 words) [view diff] exact match in snippet view article find links to article
chromatin assembly/condensation, chromosome segregation, and the mitotic spindle checkpoint Other applications for ChIP-on-chip include DNA replication, recombination
SKA2 (1,448 words) [view diff] exact match in snippet view article find links to article
regulates the maintenance of the metaphase plate and silencing of the spindle checkpoint leading to the onset of anaphase during mitosis. SKA2 also interacts
Survivin (8,364 words) [view diff] exact match in snippet view article find links to article
Marchisio PC, Altieri DC (1999). "Control of apoptosis and mitotic spindle checkpoint by survivin". Nature. 396 (6711): 580–4. doi:10.1038/25141. PMID 9859993
Induced cell cycle arrest (3,267 words) [view diff] exact match in snippet view article find links to article
dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy". Cell Cycle. 4 (10): 1385–8. doi:10.4161/cc