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searching for Stop codon 205 found (385 total)

alternate case: stop codon

List of gaited horse breeds (396 words) [view diff] exact match in snippet view article find links to article

neurological circuits related to limb movement and motion, causes a "premature 'stop codon'" in horses with lateral ambling gaits. Such breeds include the following:

Mutant protein (128 words) [view diff] exact match in snippet view article find links to article

changes by e.g. truncation of C-terminus after introducing premature stop codon. Site-directed mutagenesis Phi value analysis missense mutation nonsense

Aromatase deficiency (1,682 words) [view diff] exact match in snippet view article find links to article

Resulting in a stop codon after 21 codons 0.0 Male C to A substitution in intron V, at 3' splicing acceptor site before exon VI Premature stop codon - Male Insertion

Mdx mouse (159 words) [view diff] case mismatch in snippet view article find links to article

mutation in its DMD gene, changing the amino acid coding for a glutamine to STOP codon. This causes the muscle cells to produce a small, nonfunctional dystrophin

APOBEC1 (2,785 words) [view diff] exact match in snippet view article find links to article

inhibition of viral replication. Its function relies on introducing a stop codon into apolipoprotein B (ApoB) mRNA, which alters lipid metabolism in the

MRNA surveillance (3,394 words) [view diff] exact match in snippet view article find links to article

NMD are currently disputed. A premature stop codon must be recognized as different from a normal stop codon so that only the former triggers a NMD response

Tissue alpha-L-fucosidase (877 words) [view diff] exact match in snippet view article find links to article

PMID 10094192. Yang M, Allen H, DiCioccio RA (1993). "A mutation generating a stop codon in the alpha-L-fucosidase gene of a fucosidosis patient". Biochem. Biophys

Trace amine-associated receptor (2,036 words) [view diff] exact match in snippet view article find links to article

population. There is a polymorphism in TAAR2 (rs8192646) producing a premature stop codon at amino acid 168 in 10–15% of Asians. TAAR9 (formerly TRAR3) appears

Nonsense suppressor (856 words) [view diff] exact match in snippet view article find links to article

also be suppressed with suppressor initiator tRNAs, such as the amber stop codon suppressor tRNAfMet2(CUA). The amber initiator tRNA is charged with methionine

Ribosome display (966 words) [view diff] exact match in snippet view article find links to article

genetically fused to a spacer sequence lacking a stop codon before its end. The lack of a stop codon prevents release factors from binding and triggering

Pyrobaculum asR3 small RNA (186 words) [view diff] exact match in snippet view article find links to article

The tpi mRNA has a conserved structural element located close to the stop codon. Binding of the asR3 may be able to compete against the formation of the

Computational gene (1,236 words) [view diff] exact match in snippet view article find links to article

coding regions, the number of exons and introns, the position of start and stop codon, and the automata theoretical variables (symbols, states, and transitions)

Ribosome display (966 words) [view diff] exact match in snippet view article find links to article

genetically fused to a spacer sequence lacking a stop codon before its end. The lack of a stop codon prevents release factors from binding and triggering

Cephalodiscidae mitochondrial code (370 words) [view diff] exact match in snippet view article find links to article

the Hemichordata, except that it uses UAA for tyrosine rather than as a stop codon. This code shares with many other mitochondrial codes the reassignment

APOBEC (754 words) [view diff] exact match in snippet view article find links to article

with the codon CAA at codon 2153 and deaminates it into UAA, producing a stop codon that results in mRNA that is translated into the intestinal apoB-48 isoform

Messenger RNP (1,048 words) [view diff] exact match in snippet view article find links to article

decay if the exon-exon junction is more than 50-55 nt downstream of the stop codon. As described in a 2022 review, long-term memory utilizes messenger RNP

Alloprotein (657 words) [view diff] exact match in snippet view article find links to article

encode a "stop" signal. If one of these can be substituted by another stop codon, then that codon can in principle be "reassigned" (along with requisite

SYNE2 (1,178 words) [view diff] exact match in snippet view article find links to article

replacing YPMLRYTNGPPPT in isoforms with KASH). Utilization of an alternative stop codon in exon 115, which is followed by a distinct 3' UTR, generates deltaKASH2

SDHB (2,957 words) [view diff] exact match in snippet view article find links to article

nucleotide position 136 causing the conversion of C to U and thus generating a stop codon resulting in the translation of the edited transcripts to a truncated

Ribosome shunting (1,301 words) [view diff] exact match in snippet view article find links to article

After read through sORF A, the 80S scanning ribosome disassembles at the stop codon, which is the shunt take-off site. The 40S ribosomal subunits keep combining

Iodothyronine deiodinase (2,460 words) [view diff] exact match in snippet view article find links to article

termination of a peptide through a stop codon. In point mutation experiments with Deiodinase 1 changing UGA to the stop codon TAA resulted in a complete loss

Kohlschütter–Tönz syndrome (2,147 words) [view diff] exact match in snippet view article find links to article

This duplication that caused the frameshift resulted in a premature stop codon in the ROGDI gene after the 19th amino acid. A mutation called c.507delC

Periannan Senapathy (4,068 words) [view diff] exact match in snippet view article find links to article

the splice junctions of eukaryotic genes could have originated from the stop codon ends of the Open Reading Frames (ORFs) in random DNA sequences based on

Nidovirales (897 words) [view diff] exact match in snippet view article find links to article

UUUAAAC heptanucleotide 'slippery' sequence located upstream of the ORF1a stop codon and a putative RNA pseudoknot structure.[citation needed] Many proteins

IFNA10 (481 words) [view diff] exact match in snippet view article find links to article

Hendrix LC, Bollon AP (1985). "Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon"

RNA editing (7,437 words) [view diff] exact match in snippet view article find links to article

complementary to a pre-mature stop codon mutation in a dystrophin sequence to activate A-to-I editing of the stop codon to a read through codon in a model

Codon reassignment (1,107 words) [view diff] exact match in snippet view article find links to article

means either swapping one amino acid for another, or in the case of a stop codon, adding an amino acid where there was none before. Since the primary structure

IFNA17 (580 words) [view diff] exact match in snippet view article find links to article

Hendrix LC, Bollon AP (1985). "Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon"

Trinucleotide repeat disorder (2,709 words) [view diff] exact match in snippet view article find links to article

located in introns or in a 3' untranslated region of code beyond the stop codon. The third category, largely producing toxic proteins with polyalanines

C22orf31 (1,227 words) [view diff] exact match in snippet view article find links to article

C22orf31 gene. The C22orf31 mRNA transcript has an upstream in-frame stop codon, while the protein has a domain of unknown function (DUF4662) spanning

Paramecium (3,187 words) [view diff] exact match in snippet view article find links to article

some ciliates, like Stylonychia and Paramecium, only UGA is decoded as a stop codon, while UAG and UAA are reassigned as sense codons (that is, codons that

RNASEH2B (885 words) [view diff] exact match in snippet view article find links to article

embryonic lethality, hence genetically engineered mice with a premature stop codon in exon 7 Rnaseh2b was created. It was hypothesized that growth arrest

Cornish Rex (925 words) [view diff] exact match in snippet view article find links to article

was identified to have a 4 base pair deletion. This induces a premature stop codon in the receptor that is absent in all straight haired cats analyzed. LPAR6

Hereditary gingival fibromatosis (2,052 words) [view diff] exact match in snippet view article find links to article

creates a premature stop codon. Also, it can segregate over generations, most commonly four. Once it causes a premature stop codon, the chromosome loses

GNRHR2 (569 words) [view diff] exact match in snippet view article find links to article

N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces

Karyorelictea (1,131 words) [view diff] case mismatch in snippet view article find links to article

Petroni; Mariusz Nowacki (14 July 2016). "Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination". Cell. 166 (3): 691–702. doi:10

Endoglin (2,845 words) [view diff] exact match in snippet view article find links to article

which converts a tyrosine to stop codon a 39 base pair deletion a 2 base pair deletion which creates an early stop codon Endoglin levels have been found

Endoglin (2,845 words) [view diff] exact match in snippet view article find links to article

which converts a tyrosine to stop codon a 39 base pair deletion a 2 base pair deletion which creates an early stop codon Endoglin levels have been found

Hepadnaviridae (1,704 words) [view diff] exact match in snippet view article find links to article

these envelope protein subunits share both the same frame and the same stop codon, generating nested transcripts on a single open reading frame. The pre-S1

MT-RNR1 (899 words) [view diff] no match in snippet view article find links to article

(July 1998). "Cytochrome c oxidase deficiency associated with the first stop-codon point mutation in human mtDNA". American Journal of Human Genetics. 63

SOBP (1,012 words) [view diff] exact match in snippet view article find links to article

1346-1355 and leads to a frame-shift of the open reading frame introducing a stop codon at amino acid position 490 (S449fsX490). In the jc2J allele, the mutation

Vermiviatum covidum (978 words) [view diff] exact match in snippet view article find links to article

genes and 21 transfer RNA genes. The ND3 gene was found with a premature stop codon. In French specimens, the characteristics were similar but the length

Plasmodium helical interspersed subtelomeric protein (618 words) [view diff] exact match in snippet view article find links to article

pseudogene due to a premature stop codon. However, a missense mutation T1526G or T1526C in RESA-2 that removes this stop codon is commly found. It is associated

Phase variation (1,663 words) [view diff] exact match in snippet view article find links to article

premature stop codon or by changing the sequence of the protein. This often results in a truncated (in the case of a premature stop codon) and/or nonfunctional

Arginine:glycine amidinotransferase (1,603 words) [view diff] exact match in snippet view article find links to article

associated with AGAT involves a tryptophan codon being converted to a stop codon at residue 149. Microarray analysis from one report shows a significant

Pterobranchia (1,232 words) [view diff] exact match in snippet view article find links to article

Amino acids biochemical properties nonpolar polar basic acidic Termination: stop codon

Signature-tagged mutagenesis (346 words) [view diff] exact match in snippet view article find links to article

disrupts is also thus located (it will reside somewhere between a start and stop codon which mark the boundaries of the gene). STM can be used to discover which

ITM2B (717 words) [view diff] no match in snippet view article find links to article

S2CID 221441989. Vidal R, Frangione B, Rostagno A, et al. (1999). "A stop-codon mutation in the BRI gene associated with familial British dementia". Nature

ERV3 (1,355 words) [view diff] exact match in snippet view article find links to article

cell-cell fusion. Despite its origin as an Env gene, ERV3 has a premature stop codon that precludes any cell-cell fusion functionality. However, it does have

Properdin deficiency (1,434 words) [view diff] exact match in snippet view article find links to article

transversion on exon 6 at position 3041, converting a serine codon to a stop codon. Type II properdin deficiency is thought to be caused by one or both of

TAAR2 (946 words) [view diff] exact match in snippet view article find links to article

10–15% of Asians as a result of a polymorphism that produces a premature stop codon at amino acid 168. TCells, B Cells and Peripheral Mononuclear cells express

Eukaryotic chromosome fine structure (989 words) [view diff] exact match in snippet view article find links to article

protein (excepting various mutations). The 3' region downstream from the stop codon is separated into two parts: 3' UTR is never translated, but serves to

Neuroligin (2,607 words) [view diff] exact match in snippet view article find links to article

autism. A frame shift mutation 1186T has been found to cause an early stop codon and premature protein truncation. This mutation results in intracellular

Spiroplasma phage 1-R8A2B (1,384 words) [view diff] exact match in snippet view article find links to article

8% G, and 40% T. (UGA does not specify a stop codon in spiroplasmas; instead, the universal opal stop codon, UGA, codes for tryptophan.) It has 22.9%

UCP3 (1,952 words) [view diff] exact match in snippet view article find links to article

(V102I) was diagnosed in an obese and diabetic. A mutation initializing a stop codon at exon 4 (R143X) and a mutation in the splice donor junction of exon

Metachondromatosis (1,175 words) [view diff] exact match in snippet view article find links to article

causes a frameshift, resulting in a nonsense mutation with a premature stop codon. This causes severe truncation and loss of function in the gene’s protein

HEXA (1,986 words) [view diff] exact match in snippet view article find links to article

(TATC) in exon 11 of the Hex A gene. This insertion leads to an early stop codon, which causes the Hex A deficiency. Children born with Tay–Sachs usually

Hh blood group (1,416 words) [view diff] exact match in snippet view article find links to article

Tyr316Ter mutation in the coding region of FUT1. The mutation introduces a stop codon, leading to a truncated enzyme that lacks 50 amino acids at the C-terminal

Biomolecule (2,385 words) [view diff] exact match in snippet view article find links to article

is incorporated into some proteins at a UGA codon, which is normally a stop codon. Pyrrolysine is incorporated into some proteins at a UAG codon. For instance

Termination factor (904 words) [view diff] exact match in snippet view article find links to article

Protein signal which causes the release of transcribed RNA at a stop codon

Karyorelict nuclear code (251 words) [view diff] case mismatch in snippet view article find links to article

Petroni, Giulio; Nowacki, Mariusz (2016). "Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination". Cell. 166 (3): 691–702. doi:10

Baltimore classification (5,818 words) [view diff] no match in snippet view article find links to article

backward during translation. Suppression of termination: also called stop-codon readthrough, used by various dsRNA, +ssRNA, and ssRNA-RT viruses, certain

Fusion protein (2,305 words) [view diff] exact match in snippet view article find links to article

genetic engineering of a fusion gene. This typically involves removing the stop codon from a cDNA sequence coding for the first protein, then appending the

CRACD-like protein (1,339 words) [view diff] exact match in snippet view article find links to article

Conceptual Translation CRACDL Part 1. The upstream stop codon is orange, the exon boundaries are highlighted blue, the start codon is green, the predicted

Thraustochytrium mitochondrial code (282 words) [view diff] exact match in snippet view article find links to article

the bacterial code (translation table 11) but it contains an additional stop codon (TTA) and also has a different set of start codons. Mitochondria of Thraustochytrium

Hajdu–Cheney syndrome (1,288 words) [view diff] exact match in snippet view article find links to article

destruction of the protein. These PEST domains are removed due to the premature stop codon in the amino acid sequence. All HCS alleles are observed to have premature

Sex-lethal (1,284 words) [view diff] exact match in snippet view article find links to article

transcript includes a "male-specific exon" (exon 3) that contains an early stop codon, resulting in a truncated, non-functional protein. In females, Sxl protein

Hypogammaglobulinemia (1,955 words) [view diff] exact match in snippet view article find links to article

the maternally inherited allele had a mutation resulting in a premature stop codon in exon 13. Neither mutation was found in 100 healthy control subjects

Porphobilinogen deaminase (1,621 words) [view diff] exact match in snippet view article find links to article

"Acute intermittent porphyria caused by a C----T mutation that produces a stop codon in the porphobilinogen deaminase gene". Hum. Genet. 85 (6): 631–4. doi:10

Queuosine (499 words) [view diff] exact match in snippet view article find links to article

Bienz M, Kubli E (November 1981). "Wild-type tRNATyrG reads the TMV RNA stop codon, but Q base-modified tRNATyrQ does not". Nature. 294 (5837): 188–190.

Theta defensin (972 words) [view diff] exact match in snippet view article find links to article

genes which are transcribed to mRNA but not translated due to a premature stop codon. When the mature defensin that would be expressed is chemically synthesised

Condylostoma nuclear code (332 words) [view diff] case mismatch in snippet view article find links to article

Petroni, Giulio; Nowacki, Mariusz (2016). "Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination". Cell. 166 (3): 691–702. doi:10

Parduczia (354 words) [view diff] case mismatch in snippet view article find links to article

Giulio; Nowacki, Mariusz (28 July 2016). "Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination". Cell. 166 (3): 691–702. doi:10

Actinin (1,649 words) [view diff] exact match in snippet view article find links to article

significant role in muscle metabolism. This deficiency is due to a premature stop codon polymorphism (R577X). The R577X gene was higher in endurance athletes

Abruzzo–Erickson syndrome (907 words) [view diff] exact match in snippet view article find links to article

severely truncated proteins can result from the introduction of a premature stop codon can result from nonsense, splice-site, or frame shift sequence changes

Factor D (2,047 words) [view diff] exact match in snippet view article find links to article

serine codon (Ser42 in the unprocessed methionine form of Factor D) with a stop codon (TAG) in the Factor D gene on chromosome 19 has been documented as a cause

MT-CYB (1,863 words) [view diff] no match in snippet view article find links to article

"Mitochondrial myopathy and complex III deficiency in a patient with a new stop-codon mutation (G339X) in the cytochrome b gene". Journal of the Neurological

HSD3B1 (1,423 words) [view diff] exact match in snippet view article find links to article

AF, Smillie KJ, Mason JI (June 2002). "A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase

Saturation mutagenesis (735 words) [view diff] exact match in snippet view article find links to article

'NNS' have the benefit of encoding all 20 amino acids, but still encode a stop codon 3% of the time. Alternative codons such as 'NDT', 'DBK' avoid stop codons

RhoBTB (657 words) [view diff] exact match in snippet view article find links to article

divergent than most of the others and the transcript didn’t terminate in a stop codon like the rest. The authors, however, didn’t comment on this and RhoBTB

SARS-CoV-2 Mu variant (2,333 words) [view diff] exact match in snippet view article find links to article

a frame-shift deletion of four nucleotides in ORF3a that generates a stop codon two amino acids. The mutation is labeled as V256I, N257Q, and P258*. The

Unconventional myosin-Va (1,884 words) [view diff] exact match in snippet view article find links to article

recessive disorder. This defect is due a mutation in which a premature stop codon in the globular tail disrupt melanosome transport producing partial albinism

TMEM144 (1,186 words) [view diff] exact match in snippet view article find links to article

sequence. DNA annotations mark an upstream in-frame stop codon, start codon, exon borders, stop codon, polyadenylation signals, and polyadenylation sites

Coffin–Lowry syndrome (2,077 words) [view diff] exact match in snippet view article find links to article

despite activation by ERK. The most common mutation in RPS6KA3 is an early stop codon that fails to produce a functional protein, indicating that disease etiology

Apolipoprotein C-I (1,552 words) [view diff] exact match in snippet view article find links to article

penultimate amino acid, i.e. glutamine, in the signal sequence, resulting in a stop codon. Click on genes, proteins and metabolites below to link to respective

Hepatitis D (6,023 words) [view diff] exact match in snippet view article find links to article

isoforms are produced from the same reading frame which contains an UAG stop codon at codon 196, which normally produces only the small-HDAg. However, editing

Polyadenylation (7,094 words) [view diff] exact match in snippet view article find links to article

nucleotides long on average. The stabilising ones start at the stop codon, and without them the stop codon (UAA) is not complete as the genome only encodes the

Pathophysiology (3,038 words) [view diff] exact match in snippet view article find links to article

Colberg, J; Caro, JF (Jun 1995). "Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity". The Journal of Clinical

Familial adenomatous polyposis (3,838 words) [view diff] exact match in snippet view article find links to article

"ApcMin" mouse model was described in 1990 and carries an Apc allele with a stop codon at position 850. Heterozygosity for this mutation results in a fully penetrant

ABCD syndrome (1,725 words) [view diff] exact match in snippet view article find links to article

C to T transition resulting, at the amino acid level, in a premature stop codon." Then, they went back and defined that Shah-Waardenburg syndrome consisted

Hexosaminidase (1,464 words) [view diff] exact match in snippet view article find links to article

(TATC) in exon 11 of the Hex A gene. This insertion leads to an early stop codon, which causes the Hex A deficiency. Children born with Tay–Sachs usually

Leigh syndrome (3,180 words) [view diff] exact match in snippet view article find links to article

Robert D.S. (July 2019). "Adult-onset Leigh syndrome linked to the novel stop codon mutation m.6579G>A in MT-CO1". Mitochondrion. 47: 294–297. doi:10.1016/j

FAAH2 (369 words) [view diff] exact match in snippet view article find links to article

function. ClinVar reports a missense mutation that produces an early stop codon (Trp392Ter) is associated with Meckel-like syndrome. UniProt Variant Viewer

Glycophorin C (3,060 words) [view diff] exact match in snippet view article find links to article

deletion in exons 3 and 4 or to a frameshift mutation causing a premature stop codon in the glycophorin C gene, and persons with this phenotype are less susceptible

C8orf58 (609 words) [view diff] exact match in snippet view article find links to article

Features Transcript Variant 1 1, 2, 3, 4, 5, 6, 7 2062 One upstream in-frame stop codon. Transcript Variant 2 1, 2, 3, 4, 5, 6, 7 2038 Alternate in-frame splice

C1orf74 (870 words) [view diff] exact match in snippet view article find links to article

in humans. The transcript contains two exons and one upstream in-frame stop codon. The 5' UTR of this transcript is 343 nucleotides long and the 3' UTR

Fibroblast growth factor receptor 3 (1,844 words) [view diff] exact match in snippet view article find links to article

the child cannot breathe. There are two types. TD type I is caused by a stop codon mutation that is located in part of the gene coding for the extracellular

Loxodes (3,270 words) [view diff] exact match in snippet view article find links to article

UAG incorporate glutamine, and UGA is assigned to tryptophan or as a stop codon. This variant code is also used by other ciliates. The most recent phylogenetic

Hydrolethalus syndrome (1,505 words) [view diff] exact match in snippet view article find links to article

explicitly connected to HLS in humans. Homozygous mutations removing the stop codon in exon 4 of HYLS1 result in a different genomic sequence disruption to

Filariasis (2,876 words) [view diff] exact match in snippet view article find links to article

had an extra 29 amino acid long extension. The WbSXP-1 variant, where a stop codon has been introduced at the amino acid position 153 has been shown to be

Zinc transporter ZIP12 (2,884 words) [view diff] exact match in snippet view article find links to article

had a heterozygous deletion in SLC39A12. In another study, a premature stop codon was detected in one copy of SLC39A12 for one autistic subject. Altered

Intersectin 1 (1,238 words) [view diff] exact match in snippet view article find links to article

(ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics. 53 (3): 369–76. doi:10.1006/geno.1998.5521. PMID 9799604.

ATPase Domain 3B (452 words) [view diff] exact match in snippet view article find links to article

the strongest factor in breast cancer survival rates. A mutation in the stop codon means that ATAD3B has a 62 amino acid longer UTR. Merle, Nicolas; Féraud

Growth hormone-binding protein (2,742 words) [view diff] exact match in snippet view article find links to article

non-translation of the intracellular domain due to the presence of a stop codon. This truncated version of GHR is cleaved more frequently into GHBP and

CRISPR gene editing (20,510 words) [view diff] exact match in snippet view article find links to article

complementary to a pre-mature stop codon mutation in a dystrophin sequence to activate A-to-I editing of the stop codon to a read through codon in a model

Fungal prion (2,738 words) [view diff] exact match in snippet view article find links to article

it forms amyloid fibrils and is sequestered, leading to more frequent stop codon read-through and the development of novel phenotypes. With over 20 prion-like

WormBase (2,315 words) [view diff] case mismatch in snippet view article find links to article

the gene from the START (Methionine) codon up to (and including) the STOP codon. Any gene can code for multiple proteins as a result of alternative splicing

Lactate dehydrogenase b (622 words) [view diff] exact match in snippet view article find links to article

by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes

Phenylalanine hydroxylase (3,687 words) [view diff] exact match in snippet view article find links to article

strain using CRISPR/Cas9. Codon 7, GAG, in the Pah gene was altered to the stop codon TAG, depicting an intentional point mutation. Two to six-month-old, male

Cytochrome c oxidase subunit III (2,391 words) [view diff] no match in snippet view article find links to article

(July 1998). "Cytochrome c oxidase deficiency associated with the first stop-codon point mutation in human mtDNA". American Journal of Human Genetics. 63

Blue–white screen (1,821 words) [view diff] case mismatch in snippet view article find links to article

This occurs when the insert is "in frame" with the LacZα gene and a STOP codon is absent in the insert. This can lead to the expression of a fusion protein

Allergic bronchopulmonary aspergillosis (3,823 words) [view diff] exact match in snippet view article find links to article

cystic fibrosis patients and a ZNF77 mutation resulting in a premature stop codon in asthmatics and ABPA patients). By allowing Aspergillus spores to persist

Point mutation (4,371 words) [view diff] exact match in snippet view article find links to article

means that a codon coding for the amino acid glycine may be changed to a stop codon, causing the proteins that should have been produced to be deformed and

Condylostoma (2,271 words) [view diff] exact match in snippet view article find links to article

not translation is ended seems to be dependent on the location of the "stop codon" in the transcript and how close they are to the 3′ end of the mRNA. Condylostoma

NDUFA12 (1,196 words) [view diff] exact match in snippet view article find links to article

cytosine to tyrosine mutation at position 178 that leads to a premature stop codon has been found in place of arginine at amino acid 60, leading to delayed

C9orf152 (701 words) [view diff] exact match in snippet view article find links to article

consists of 2698 base pairs. Nucleotides 66-68 encode an upstream in frame stop codon. C9orf152 has orthologs in mammals, birds, reptiles and amphibians. No

Cathepsin D (2,623 words) [view diff] exact match in snippet view article find links to article

duplication in exon 6 could alter the reading frame and causes a premature stop codon at position 255. Over-expression of cathepsin D stimulates tumorigenicity

Uridine monophosphate synthase (3,560 words) [view diff] exact match in snippet view article find links to article

model organism Caenorhabditis elegans. The rad-6 strain has a premature stop codon eliminating the orotidine 5’-decarboxylase domain of the protein; this

Chromosome 4 open reading frame 50 (524 words) [view diff] exact match in snippet view article find links to article

exons, a coding sequence of 6370 nucleotides, and an upstream in-frame stop codon. Other genes in the gene neighborhood include: CRMP1 and JAKMIP1 C4orf50

Familial Danish dementia (1,085 words) [view diff] exact match in snippet view article find links to article

stereotyped behavior. FDD is caused by a 10-nucleotide duplication prior to the stop codon of the BRI2/ITM2B gene. In healthy people, BRI2 is produced as an immature

List of genetic codes (615 words) [view diff] exact match in snippet view article find links to article

Amino-acid biochemical properties Nonpolar Polar Basic Acidic Termination: stop codon *

Interleukin 8 (3,456 words) [view diff] exact match in snippet view article find links to article

in the 3' untranslated region (3' UTR) of IL-8 immediately after the stop codon. The 3' UTR of CXCL8 also contains adenylate-uridylate-rich elements (AREs)

STAG3 (gene) (1,357 words) [view diff] exact match in snippet view article

sperm. To elaborate, a missense mutation, which resulted in a premature stop codon, leading to a complete loss of function in STAG3 caused infertility in

Non-proteinogenic amino acids (2,864 words) [view diff] exact match in snippet view article find links to article

amino acids do not have a dedicated codon, but are added in place of a stop codon when a specific sequence is present, UGA codon and SECIS element for selenocysteine

Gene knockout (2,563 words) [view diff] exact match in snippet view article find links to article

Frameshift mutation resulting from a single base pair deletion, causing altered amino acid sequence and premature stop codon

C2orf74 (2,326 words) [view diff] exact match in snippet view article find links to article

font. The 5'UTR of this protein is shown to have an upstream in frame stop codon (red), and an upstream in frame start codon (green). The putative N-terminal

Ectrodactyly–ectodermal dysplasia–cleft syndrome (2,617 words) [view diff] exact match in snippet view article find links to article

as a nonsense mutation. The frameshift mutation introduces a premature stop codon that affected the α isotope, but does not affect the β and γ isotopes

Mitochondrion (18,655 words) [view diff] exact match in snippet view article find links to article

Arginine Stop codon Invertebrates AGA, AGG Arginine Serine Fungi CUA Leucine Threonine All of the above AUA Isoleucine Methionine UGA Stop codon Tryptophan

Androgen insensitivity syndrome (12,546 words) [view diff] exact match in snippet view article find links to article

mutation can affect all downstream functional domains if a premature stop codon or framing error results; such a mutation can result in a completely unusable

SBDS (1,580 words) [view diff] no match in snippet view article find links to article

this syndrome are at positions 183–184 (TA→CT) resulting in a premature stop-codon (K62X) and a frameshift mutation at position 258 (2T→C) resulting in a

UPF0602 (1,059 words) [view diff] exact match in snippet view article find links to article

1. This variant contains a total of 8 exons with an upstream in-frame stop codon located within the first exon, a disordered region, and a domain of unknown

CXorf65 (1,266 words) [view diff] exact match in snippet view article find links to article

mutation due to a 19 bp deletion in exon 2. This results in a premature stop codon 126 bp from the start of translation. Human CXorf65 is ubiquitously expressed

Formylation (2,838 words) [view diff] exact match in snippet view article find links to article

alter exon splicing leading to a frameshift mutation and a premature stop codon. Individuals with the MTFMT c.626C>T mutation were found to have reduced

FAM131A (929 words) [view diff] exact match in snippet view article find links to article

signals, polyadenylation sites, disordered region, region excluded from isoform 2, and stop codon. Amino acids conserved from distant orthologs are bolded.

Titin (4,671 words) [view diff] exact match in snippet view article find links to article

splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect. mRNA splicing factors such as RBM20 and SLM2

Shapiro–Senapathy algorithm (6,804 words) [view diff] exact match in snippet view article find links to article

neighboring intron or lose a partial exon, which may result in a premature stop codon. The result may be a truncated protein that would have lost its function

MiR-155 (10,217 words) [view diff] exact match in snippet view article find links to article

binding site is located 46–53 base pairs downstream from the SPI1 mRNA stop codon. The requisite "seed sequence" base-pairing is denoted by the bold dashes

KIAA0922 (1,306 words) [view diff] exact match in snippet view article find links to article

of the 3' and 5' ends (especially due to the presence of an upstream stop codon in the exonic region). Protein TMEM131L is an integral membrane protein

TBC1D4 (1,508 words) [view diff] exact match in snippet view article find links to article

not effect the short isoform of the protein, it introduces a premature stop codon in the long isoform, resulting in the absence of the long isoform protein

HLA-G (3,097 words) [view diff] exact match in snippet view article find links to article

encodes the cytoplasmic tail. Exon 7 and 8 are not translated due to a stop codon present in exon 6. HLA-G can be expressed under at least seven isoforms

C16orf86 (2,429 words) [view diff] exact match in snippet view article find links to article

at a amino acid 1 Methionine and goes until amino acid 317, which is a stop codon. There are 2 isoforms of C16orf86, which is uncharacterized protein C16orf86

SPATS1 (957 words) [view diff] exact match in snippet view article find links to article

possibly due to it being produced at low levels because of an immature stop codon. Bioinformatic analysis suggests that the protein does not have transmembrane

Phage display (4,630 words) [view diff] exact match in snippet view article find links to article

without greatly affecting pVI's role in phage assembly. This means that the stop codon in the cDNA is no longer an issue. However, phage display of cDNA is always

BED (file format) (1,495 words) [view diff] exact match in snippet view article

longer displayed in a thicker way on a graphical representation (e.g.: the stop codon of a gene) No 9 itemRgb RGB value in the form R, G, B (e.g. 255,0,0) determining

PDE6B (2,159 words) [view diff] exact match in snippet view article find links to article

near the first exon combined with a point mutation, which introduces a stop codon in exon 7. In addition to the rd1 mouse, a missense mutation (R560C) in

Mycoplasma pneumoniae (4,676 words) [view diff] exact match in snippet view article find links to article

pneumoniae uses the codon UGA to code for tryptophan rather than using it as a stop codon. Mycoplasma pneumoniae has a reduced metabolome in comparison to other

Transfer RNA (8,271 words) [view diff] exact match in snippet view article find links to article

inserted into E. coli, causing it to initiate protein synthesis at the UAG stop codon, as long as it is preceded by a strong Shine-Dalgarno sequence. At initiation

Attenuator (genetics) (2,243 words) [view diff] exact match in snippet view article

interruption and will only stall during translation termination at the stop codon. At this point the ribosome physically shields both sequences 1 and 2

Extrachromosomal DNA (5,349 words) [view diff] exact match in snippet view article find links to article

Amino acids biochemical properties nonpolar polar basic acidic Termination: stop codon

GLIMMER (2,898 words) [view diff] exact match in snippet view article find links to article

Scoring of ORF in GLIMMER 3.0 is done in reverse order i.e., starting from stop codon and moves back towards the start codon. Reverse scanning helps in identifying

Nuclear cap-binding protein complex (1,489 words) [view diff] exact match in snippet view article find links to article

translated a new nuclear cap-binding protein complex-bound mRNA has a stop codon that is found more than 50-55 nucleotides upstream of an exon-junction

SMIM19 (2,273 words) [view diff] exact match in snippet view article find links to article

alternative ones, along with an upstream in-frame stop codon. Not all variants contain the upstream in-frame stop codon as it is present in the portion of the 5'

Circular permutation in proteins (3,511 words) [view diff] exact match in snippet view article find links to article

1-2-3-1-2-3. Next, a start codon is introduced before the first domain 2 and a stop codon after the second domain 1, removing redundant sections and resulting in

Single-domain antibody (3,905 words) [view diff] exact match in snippet view article find links to article

occasionally produce single domain antibodies by the random creation of a stop codon in the light chain. Human single-domain antibodies targeting various tumor

UBALD1 (1,173 words) [view diff] exact match in snippet view article find links to article

exon 1, causing a frameshift of codons and earlier occurrence of its stop codon. Isoform 3 also lacks the PHA03247 domain. The protein encoded by UBALD1

Ensembl Genomes (2,996 words) [view diff] exact match in snippet view article find links to article

variants How the variant affects the protein synthesis (e.g. generating a stop codon) Comparison with other databases to find equal known variants There are

Eastern equine encephalitis (6,163 words) [view diff] exact match in snippet view article find links to article

create a polyprotein that contains the non-structural proteins, P1234. A stop codon exists between the genes for nsP3 and nsP4, so many polyproteins are P123

MUTYH (2,955 words) [view diff] exact match in snippet view article find links to article

Consequently, a frameshift occurred due to the insertion and a premature stop codon was read at 438 on the gene. Pilomatricoma was the phenotypic manifestation

Chloroplast DNA (5,889 words) [view diff] exact match in snippet view article find links to article

non-functional pseudogene by adding an AUG start codon or removing a premature UAA stop codon. The editosome recognizes and binds to cis sequence upstream of the editing

RAD52 (3,093 words) [view diff] exact match in snippet view article find links to article

De Vivo I, Colditz GA, Hunter DJ (Oct 2002). "No association between a stop codon polymorphism in RAD52 and breast cancer risk". Cancer Epidemiology, Biomarkers

Elizabeth Maywood (1,272 words) [view diff] exact match in snippet view article find links to article

vector contained noncanonical amino acids (ncAA) and an ectopic amber stop codon resulting in a silencing mutation. When arrhythmic SCN slices lacking

Molecular autopsy (1,912 words) [view diff] exact match in snippet view article find links to article

potassium channel to cause a shift of amino acids. This shift is where the stop codon at an amino acid is introduced and needed. This can severely impact the

List of restriction enzyme cutting sites: Ba–Bc (2,404 words) [view diff] no match in snippet view article find links to article

PMC 146408. PMID 9016548. Rowland GC, Lim PP, Glass RE (July 1992). "'Stop-codon-specific' restriction endonucleases: their use in mapping and gene manipulation"

Eilat virus (1,413 words) [view diff] exact match in snippet view article find links to article

Reading Frame which is an incessant stretch of codons that do not contain a stop codon). Four nonstructural proteins are encoded on two-thirds of the genome

Fam78b (692 words) [view diff] exact match in snippet view article find links to article

in Homo sapiens located on the 3' end of the mRNA at 88-95 after the stop codon (bp 167,091,390-167,091,397 on chromosome 1). Stem loop from 155-172 of

Rex mutation (2,829 words) [view diff] exact match in snippet view article find links to article

transcription machinery to sense the end of the gene prematurely. The stop codon generated by the deletion may be shortening the protein by 19 amino acids

TEDC2 (1,503 words) [view diff] exact match in snippet view article find links to article

the 6 TEDC2 isoforms. Green = contains a start codon. Red = contains a stop codon. Check = Exon included in the final mRNA transcript. -- = exon is excluded

Potato mop-top virus (2,306 words) [view diff] exact match in snippet view article find links to article

or minor CP, which is produced by translational read-through of the CP stop codon. The third segment, RNA-TGB encodes triple gene block of movement proteins

GENCODE (2,646 words) [view diff] no match in snippet view article find links to article

{ENSEMBL,HAVANA} 3 feature-type {gene,transcript,exon,CDS,UTR,start_codon,stop_codon,Selenocysteine} 4 genomic start location integer-value (1-based) 5 genomic

Lily virus X (1,913 words) [view diff] exact match in snippet view article find links to article

protein, while also encoding for RNA-dependent RNA polymerase (RdRp). The stop codon of the 24 kDa ORF and the start codon of the 12 kDa ORF overlap one another

MYH9 (6,349 words) [view diff] exact match in snippet view article find links to article

with the first ATG of the open reading frame localized in exon 2 and the stop codon in exon 41. It encodes non-muscle myosin heavy chain IIA (NMHC IIA), a

Killer-cell immunoglobulin-like receptor (4,273 words) [view diff] exact match in snippet view article find links to article

the cytoplasmic tail to be long or short, depending on the site of the stop codon. These single nucleotide alterations in the nucleotide sequence fundamentally

Secreted frizzled-related protein 1 (6,321 words) [view diff] exact match in snippet view article find links to article

67delG) and a single-base change (G450A), which generates an in-frame stop codon. These three mutations were found within the first exon, which was shown

C19orf47 (440 words) [view diff] exact match in snippet view article find links to article

SIXFRAME. Exon-exon boundaries are in blue, start codon is in green, and stop codon is red. PolyA signal sequence is shown in dark orange, polyA sites are

FAM120AOS (2,932 words) [view diff] exact match in snippet view article find links to article

FAM120AOS isoform 1 is 5922 bp long and contains an upstream in-frame stop codon (taa) at 807-809 bp. There are 12 known isoforms of the human FAM120AOS

C6orf222 (1,399 words) [view diff] exact match in snippet view article find links to article

transcript that is 3,750 base pairs long. There is a unique upstream, in-frame stop codon in the 5’UTR region from base pairs 86-88 of the mRNA. The gene PNPLA1

C5orf22 (1,029 words) [view diff] exact match in snippet view article find links to article

alpha-helix. B-sheet:Beta-pleated sheet. NLS:Nuclear localization signal.Stop: Stop codon. miRNA site: miRNA site with target score of 98%, indicated by miRDB.

Epigenetics (18,196 words) [view diff] exact match in snippet view article find links to article

PSI+ state and express dormant genetic features normally terminated by stop codon mutations. Prion-based epigenetics has also been observed in Saccharomyces

STAU1 (2,553 words) [view diff] exact match in snippet view article find links to article

involves direct binding of STAU1 to SBS, which is located downstream of the stop codon of the target mRNA. Once STAU1 is bound to the target mRNA, an interaction

LENG9 (1,513 words) [view diff] exact match in snippet view article find links to article

is located 119 bp upstream of the start codon as well as an in-frame stop codon at 1087 bp to 1089 bp. In humans, LENG9 has two mRNA unspliced transcript

Transcription-translation coupling (2,238 words) [view diff] exact match in snippet view article find links to article

translation when the ribosome pauses[citation needed] or encounters a premature stop codon. This allows the transcription termination factor Rho to bind the mRNA

Pathophysiology of obesity (2,353 words) [view diff] exact match in snippet view article find links to article

Colberg, J; Caro, JF (Jun 1995). "Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity". The Journal of Clinical

Spizellomyces punctatus (2,435 words) [view diff] exact match in snippet view article find links to article

leucine codons. tRNALeu recognizes the UAG codon as leucine instead of the stop codon. tRNAs form secondary structures that are composed of helical stems. Predicted

Labrador Retriever coat colour genetics (3,101 words) [view diff] exact match in snippet view article find links to article

R.; Rothuizen, J.; van Oost, B (2000). "Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) in Labrador

Osteogenesis imperfecta (15,404 words) [view diff] exact match in snippet view article find links to article

Larsson S, et al. (September 2018). "Homozygosity for CREB3L1 premature stop codon in first case of recessive osteogenesis imperfecta associated with OASIS-deficiency

SMIM23 (1,806 words) [view diff] exact match in snippet view article find links to article

Conceptual Translation of SMIM23. Labeled are the start and stop codon, exon splice sites, polyadenylation signal as well as singly conserved based highlighted

Gene therapy of the human retina (5,010 words) [view diff] exact match in snippet view article find links to article

mutation in a receptor tyrosine kinase gene, mertk results in a premature stop codon and impaired phagocytosis function by RPE cells. This mutation causes

Artificial gene synthesis (7,073 words) [view diff] exact match in snippet view article find links to article

fusion proteins, as the 6bp scar sequence codes for a tyrosine and a stop codon, causing translation to be terminated after the first domain is expressed

Cruciferin (1,498 words) [view diff] exact match in snippet view article find links to article

investigations, CRU3, one of the main cruciferin genes, introduced a premature stop codon, leading to the occurrence of ssp1. The disulfide bonds in question do

Impulsivity (15,737 words) [view diff] exact match in snippet view article find links to article

Zhifeng; Wedenoja, Juho; et al. (2010). "A population-specific HTR2B stop codon predisposes to severe impulsivity". Nature. 468 (7327): 1061–6. Bibcode:2010Natur

TMED5 (1,931 words) [view diff] exact match in snippet view article find links to article

Conceptual translation of TMED5. Labeled are the start and stop codon, exon splice sites, domains and motifs, polyadenylation signals, predicted RNA and

Progeroid syndromes (8,748 words) [view diff] exact match in snippet view article find links to article

precursor, and insertions in the ZMPSTE24, which lead to a premature stop codon. Individuals with RD exhibit growth retardation starting in the uterus

C19Orf81 (1,156 words) [view diff] exact match in snippet view article find links to article

Translational sequence for C19Orf81. The start codon is green, the stop codon is red and the legend is color coded accordingly.

List of restriction enzyme cutting sites: A (3,046 words) [view diff] no match in snippet view article find links to article

1099/00221287-131-4-951. PMID 2985742. Rowland GC, Lim PP, Glass RE (July 1992). "'Stop-codon-specific' restriction endonucleases: their use in mapping and gene manipulation"

SBK3 (2,118 words) [view diff] exact match in snippet view article find links to article

polyadenylation signal ‘TATAAA’ is found 622 bases downstream from the stop codon. SBK3 has a large conserved catalytic domain specific to the protein kinase

Glossary of genetics and evolutionary biology (15,980 words) [view diff] exact match in snippet view article find links to article

nonsense mutation A type of point mutation which results in a premature stop codon in the transcribed mRNA sequence, thereby causing the premature termination

TMEM212 (1,636 words) [view diff] exact match in snippet view article find links to article

exons, a coding sequence of 1881 nucleotides, and an upstream in-frame stop codon. The coding sequence is the 36-660 bases of the gene TMEM212. Other genes

Aldehyde tag (2,928 words) [view diff] exact match in snippet view article find links to article

a chemical reporter using various techniques, including methods like stop codon suppression and aldehyde tagging. Limiting the use of aldehydes and ketones

De novo gene birth (13,540 words) [view diff] exact match in snippet view article find links to article

becoming constitutively expressed through a mutation that disrupts the stop codon. Genes experiencing high translational readthrough tend to have intrinsically

Substitution model (8,854 words) [view diff] exact match in snippet view article find links to article

would involve the possibility of passing through a state with a premature stop codon. An alternative (and commonly used) way to write the instantaneous rate

De novo mutation (10,140 words) [view diff] exact match in snippet view article find links to article

offspring. Nonsense Mutation Lastly a nonsense mutation causes a premature stop codon in, which leads to a discontinuation of protein synthesis for that transcript

Epitranscriptomic sequencing (6,385 words) [view diff] exact match in snippet view article find links to article

by m6A-CLIP reveals that m6A is enriched at last exon but not around stop codon. In m6A-CLIP and miCLIP, RNA is fragmented to ~20-80nt first, then the

RNA-targeting small molecule drugs (4,401 words) [view diff] exact match in snippet view article find links to article

patients with DMD who have a single mutation in the DMD gene causing a stop codon to appear prematurely (nonsense mutation). Compared to the number of drug

GPATCH2L (1,905 words) [view diff] exact match in snippet view article find links to article

secondary structure of human GPATCH2L (5’UTR) shows one stem-loop, inframe stop codon, start codon, and exon boundaries. In this stem-loop, g and g are not

RBM10 (5,530 words) [view diff] exact match in snippet view article find links to article

alternative splicing to exclude exon 6 or 12, which generates a premature stop codon in the transcripts, leading to their degradation through nonsense-mediated