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an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, butRuslan Medzhitov (566 words) [view diff] exact match in snippet view article find links to article
Hughes Medical Institute. His research focuses on the analysis of the innate immune system, inflammatory response, innate control of the adaptive immunity,Ceragenin (514 words) [view diff] exact match in snippet view article find links to article
also seen in antimicrobial peptides, which form part of the body's innate immune system, they avoid many of the difficulties associated with their use asKLRD1 (1,386 words) [view diff] exact match in snippet view article find links to article
signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2TIRAP (179 words) [view diff] exact match in snippet view article find links to article
is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs)C3b (1,157 words) [view diff] exact match in snippet view article find links to article
complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization: tagging pathogens, immune complexesComplement component 5a (1,654 words) [view diff] exact match in snippet view article find links to article
membrane attack complex (MAC), one of the most basic weapons of the innate immune system, formed as an automatic response to intrusions from foreign particlesSeung-Yong Seong (1,416 words) [view diff] exact match in snippet view article find links to article
South Korean immunologist and microbiologist known for his study of innate immune system response and his development of the damage-associated molecular patternMuramyl dipeptide (419 words) [view diff] exact match in snippet view article find links to article
leucine-rich repeat family, is a cytoplasmic receptor involved in host innate immune system defense. Mutations in the CARD15 gene encoding NOD2 protein haveLeucophenga varia (149 words) [view diff] exact match in snippet view article find links to article
which has impacted the evolution of the Diptericin gene of its innate immune system. "Leucophenga varia Report". Integrated Taxonomic Information SystemImmunological memory (2,961 words) [view diff] exact match in snippet view article find links to article
the basis of vaccination. Emerging resources show that even the innate immune system can initiate a more efficient immune response and pathogen eliminationThioester-containing protein 1 (1,740 words) [view diff] exact match in snippet view article find links to article
protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 throughGiardiasis (5,501 words) [view diff] no match in snippet view article find links to article
Giardiasis is a parasitic disease caused by Giardia duodenalis (also known as G. lamblia and G. intestinalis). Infected individuals who experience symptomsMihai Netea (2,195 words) [view diff] exact match in snippet view article find links to article
University Nijmegen Medical Center. Netea's field of study includes the innate immune system and its capacity to "memorize" infections, as well as its recognitionAsparagine endopeptidase (1,932 words) [view diff] no match in snippet view article find links to article
Asparagine endopeptidase (AEP, mammalian legumain, δ-secretase; EC 3.4.22.34) is a proteolytic enzyme from C13 peptidase family which hydrolyses a peptideAureolysin (1,715 words) [view diff] exact match in snippet view article find links to article
virulence, or ability to cause disease, by cleaving host factors of the innate immune system as well as regulating S. aureus secreted toxins and cell wall proteinsParaoxonase (1,791 words) [view diff] exact match in snippet view article find links to article
Evidence also suggests that this family of enzymes has some role in our innate immune system. There are three known paraoxonases, which are encoded by the genesApolipoprotein B (4,836 words) [view diff] no match in snippet view article find links to article
Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Its measurement is commonly used to detect risk of atherosclerotic cardiovascularInterleukin 8 (3,456 words) [view diff] exact match in snippet view article find links to article
secreted and is an important mediator of the immune reaction in the innate immune system response. IL-8, also known as monocyte-derived neutrophil chemotacticMARCO (2,234 words) [view diff] exact match in snippet view article find links to article
cell signaling events that lead to inflammation. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatoryNLRP (2,056 words) [view diff] exact match in snippet view article find links to article
recognizing signals of antigens in the cell. NLRP proteins are part of the innate immune system and detect conserved pathogen characteristics, or pathogen-associatedHydrophis cyanocinctus (822 words) [view diff] exact match in snippet view article find links to article
and skin. Gene-encoded AMPs represent the main component of an innate immune system that protects snakes from microbial infections. Sea snakes inhabitLow-density lipoprotein (6,996 words) [view diff] no match in snippet view article find links to article
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. TheseCell–cell recognition (2,051 words) [view diff] exact match in snippet view article find links to article
and B cells. Cell–cell recognition is especially important in the innate immune system, which identifies pathogens very generally. Central to this processPlant defensin (3,924 words) [view diff] exact match in snippet view article find links to article
pathogens and parasites. Defensins are integral components of the innate immune system and belong to the ancient superfamily of antimicrobial peptides (AMPs)High Affinity K+ transporter HAK5 (2,308 words) [view diff] exact match in snippet view article find links to article
which is involved in the innate immune system for living cells. PAMPs are the main molecules that run the innate immune system. They consist of eitherBlau syndrome (1,387 words) [view diff] exact match in snippet view article find links to article
sparked investigation into its function as part of the innate immune system. The innate immune system recognizes pathogen-associated molecular patterns, includingPassive antibody therapy (2,923 words) [view diff] exact match in snippet view article find links to article
laboratory to elicit an immune response instead of relying on the innate immune system to fight disease. It has a long history from the 18th century forImmunoediting (1,356 words) [view diff] exact match in snippet view article find links to article
involves the initiation of an antitumor immune response. Cells of the innate immune system recognize the presence of a growing tumor which has undergone stromalUrticarial vasculitis (715 words) [view diff] exact match in snippet view article find links to article
ability to link the two important arms of the immune system – the innate immune system: a broad defence system; and the adaptive immune system: the strongDial (soap) (587 words) [view diff] case mismatch in snippet view article
2013. Retrieved 10 May 2012. Dayan, Nava; Wertz, Philip W. (2011). Innate Immune System of Skin and Oral Mucosa: Properties and impact in pharmaceutics,Richard Smeyne (606 words) [view diff] exact match in snippet view article find links to article
interactions of the peripheral immune system with that of the brain’s innate immune system immune as well as the role of viruses in the etiology of Parkinson’sTonsil (1,585 words) [view diff] exact match in snippet view article find links to article
PMID 35582809. Braunstein, Michael J. (2023). "Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort". Nature Immunology. 24Induced-self antigen (534 words) [view diff] exact match in snippet view article find links to article
(2002-04-12). "Decoding the patterns of self and nonself by the innate immune system". Science. 296 (5566): 298–300. Bibcode:2002Sci...296..298M. CiteSeerX 10Margie Profet (1,318 words) [view diff] exact match in snippet view article find links to article
Phospholipase A2—the major allergen in bee venom -- "is sensed by the innate immune system" and induces an immune response in mice that can protect againstPolly Matzinger (2,271 words) [view diff] exact match in snippet view article find links to article
proposal that the innate immune system was the real gatekeeper of immune system responses. He also theorized that the innate immune system used ancient pattern-recognitionAPOBEC (782 words) [view diff] exact match in snippet view article find links to article
APOBEC family proteins are widely expressed in cells of the human innate immune system. These enzymes, when misregulated, are a major source of mutationSIGLEC10 (754 words) [view diff] exact match in snippet view article find links to article
motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405)Slow virus (600 words) [view diff] exact match in snippet view article find links to article
Bradford BM, Mabbott NA (December 2012). "Prion disease and the innate immune system". Viruses. 4 (12): 3389–3419. doi:10.3390/v4123389. PMC 3528271.RNA interference (15,409 words) [view diff] exact match in snippet view article find links to article
divided into two separate branches: the innate immune system and the adaptive immune system. The innate immune system is the first defense against infectionJohannes F. Coy (840 words) [view diff] exact match in snippet view article find links to article
monocytes (EDIM) - detection method of biomarkers in cells of the innate immune system in blood samples Automated flow cytrometry method Flow cytometry-basedEF-Tu receptor (1,511 words) [view diff] exact match in snippet view article find links to article
and portions that extend beyond the membrane. They are part of the innate immune system and bind to and prevent the proliferation of pathogens with the PAMPsDSCAM (3,755 words) [view diff] exact match in snippet view article find links to article
antibody-based immune systems. Instead, invertebrates rely on their innate immune system to eliminate infectious entities. The task of detecting and respondingVernix caseosa (1,335 words) [view diff] case mismatch in snippet view article find links to article
Narendran V, Visscher MO (2011). "Vernix Caseosa and Innate Immunity". Innate Immune System of Skin and Oral Mucosa. John Wiley & Sons, Ltd. pp. 145–169. doi:10CTAG1B (2,389 words) [view diff] exact match in snippet view article find links to article
macrophages and dendritic cells provides a link between CTAG1B, the innate immune system, and possibly the adaptive immune response against CTAG1B. GRCh38:Rudolph E. Tanzi (4,371 words) [view diff] exact match in snippet view article find links to article
Abeta to be a potent antimicrobial peptide (AMP) in the brain's innate immune system. After showing that the beta-amyloid protein protects against variousUterine natural killer cells (1,098 words) [view diff] exact match in snippet view article find links to article
Uterine natural killer cells do not have a fundamental role in the innate immune system and therefore, are not cytotoxic. Throughout pregnancy, there isCFHR5 (719 words) [view diff] exact match in snippet view article find links to article
which plays an important role in the regulation of a branch of the innate immune system called the alternative complement pathway. Like complement factorMMP8 (1,257 words) [view diff] exact match in snippet view article find links to article
production, suggesting a role for MMP-8 in the regulation of the innate immune system. GRCh38: Ensembl release 89: ENSG00000118113 – Ensembl, May 2017Leucine-rich repeat receptor like protein kinase (1,423 words) [view diff] exact match in snippet view article find links to article
the expression of PDF1.2 (defensin) gene being component of plant innate immune system. Expression of these defense genes would result in more productionImiquimod (1,685 words) [view diff] exact match in snippet view article find links to article
several immunological levels synergistically. Imiquimod stimulates the innate immune system by activating toll-like receptor 7 (TLR7), commonly involved in pathogenNeil Gow (microbiologist) (828 words) [view diff] exact match in snippet view article
"An integrated model of the recognition of Candida albicans by the innate immune system". Nature Reviews Microbiology. 6 (1): 67–78. doi:10.1038/nrmicro1815Plant lipid transfer proteins (1,062 words) [view diff] case mismatch in snippet view article find links to article
Ovchinnikova TV (2016). "Lipid Transfer Proteins As Components of the Plant Innate Immune System: Structure, Functions, and Applications". Acta Naturae. 8 (2): 47–61Glucan (1,686 words) [view diff] exact match in snippet view article find links to article
Andrea; Underhill, David (29 June 2009). "β-glucan recognition by the innate immune system". Immunological Reviews. 230 (1): 38–50. doi:10.1111/j.1600-065XCARD (domain) (1,439 words) [view diff] exact match in snippet view article
Tschopp J (2004). "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases". Cell. 117 (5): 561–74. doi:10.1016/jAsian water monitor (4,180 words) [view diff] case mismatch in snippet view article find links to article
Water Monitor) Reveals Adaptations in the Blood Coagulation and Innate Immune System". Frontiers in Ecology and Evolution. 10. Frontiers Media S.A. doi:10Five-prime cap (2,004 words) [view diff] exact match in snippet view article find links to article
is more common in higher eukaryotes and thought to be part of the innate immune system to recognize mRNAs from other organisms. In multicellular eukaryotesAntigen (2,434 words) [view diff] exact match in snippet view article find links to article
component of vaccines plays an essential role in the activation of the innate immune system. An immunogen is an antigen substance (or adduct) that is able toLung microbiota (1,725 words) [view diff] case mismatch in snippet view article find links to article
Kawai, Taro; Akira, Shizuo (2011). "Pathogen Recognition by the Innate Immune System". International Reviews of Immunology. 30 (1): 16–34. doi:10.3109/08830185Kupffer cell (1,861 words) [view diff] exact match in snippet view article find links to article
conserved in mice and humans and is a critical component of the innate immune system. Kupffer cells are incredibly plastic cells that have the capabilityHuman milk immunity (3,105 words) [view diff] exact match in snippet view article find links to article
mammary gland and milk production evolved as a part of the human innate immune system, with its immunological protective role predating its nutritionalNecroptosis (1,667 words) [view diff] exact match in snippet view article find links to article
necroptosis. TLRs are a class of receptors that function in the innate immune system to recognize conserved components of pathogens, such as flagellinCancer cell (2,344 words) [view diff] case mismatch in snippet view article find links to article
'evil twin' cancer cells". ScienceDaily. Retrieved 2025-02-24. "The Innate Immune System: NK Cells". Community College of Baltimore County. Archived fromTheiler's murine encephalomyelitis virus (1,153 words) [view diff] exact match in snippet view article find links to article
hypothesis for the initiation is that an infection stimulates the innate immune system, specifically perivascular microglia. This allows the entrance ofCholesterol embolism (1,438 words) [view diff] exact match in snippet view article find links to article
vasculitis; complement is a group of proteins that forms part of the innate immune system. Complement levels are frequently reduced in cholesterol embolismCathepsin F (994 words) [view diff] exact match in snippet view article find links to article
mortality due to bacterial diseases. Understanding the workings of its innate immune system, in various embryonic developmental stages, may help the associatedJanet Mary Lord (681 words) [view diff] exact match in snippet view article find links to article
Greenwood; Alexander Panda; Janet M Lord (1 August 2010). "Aging of the innate immune system". Current Opinion in Immunology. 22 (4): 507–513. doi:10.1016/J.COIFDC-SP (1,089 words) [view diff] exact match in snippet view article find links to article
surfactant proteins A and D, which are thought to be involved in the innate immune system of the lung. These proteins allow for the phagocytosis of bacteriaAnthony Gordon (clinical scientist) (1,260 words) [view diff] exact match in snippet view article
28 December 2023. Gordon, Anthony. Genetic polymorphisms of the innate immune system : influence on susceptibility and outcome in severe sepsis and septicHoward L. Weiner (2,350 words) [view diff] exact match in snippet view article find links to article
from the institutes' Directors office for the investigation of the innate immune system in Alzheimer's Disease. Of 750 applications for the award, only 20Sepsis (13,631 words) [view diff] exact match in snippet view article find links to article
are recognized by the pattern recognition receptors (PRRs) of the innate immune system, which may be membrane-bound or cytosolic. There are four familiesKarin E. de Visser (613 words) [view diff] exact match in snippet view article find links to article
she started working on the interaction between the adaptive and innate immune system. She spent two years in California, before returning to the NetherlandsRadial immunodiffusion (1,959 words) [view diff] exact match in snippet view article find links to article
liquid or semifluid media. Squire JD, Leiding JW (2022). "Testing the innate immune system". Allergic and Immunologic Diseases. pp. 725–735. doi:10.1016/B978-0-323-95061-9Drew Weissman (1,980 words) [view diff] exact match in snippet view article find links to article
of Pennsylvania to start his laboratory in order to study RNA and innate immune system biology. He is now the Roberts Family Professor in Vaccine ResearchClassical complement pathway (1,885 words) [view diff] exact match in snippet view article find links to article
the target cell membranes to lysing. Because of its role in the innate immune system classical complement has been implicated in a number of pathogenWaxworm (1,457 words) [view diff] exact match in snippet view article find links to article
fungal pathogens. Waxworms prove valuable in such studies because the innate immune system of insects is strikingly similar to that of mammals. Waxworms surviveRhabdoviridae (2,697 words) [view diff] exact match in snippet view article find links to article
for specific encapsulation. P protein interferes with the host's innate immune system through inhibition of the activities of interferon regulatory factorColostrum (5,897 words) [view diff] exact match in snippet view article find links to article
immune components of colostrum include the major components of the innate immune system, such as lactoferrin, lysozyme, lactoperoxidase, complement, andJoan Massagué (1,400 words) [view diff] exact match in snippet view article find links to article
lung cancers, and the interplay of metastatic stem cells with the innate immune system. On January 13, 2020, a study by Massagué-led Sloan Kettering InstituteArbitrium (1,286 words) [view diff] exact match in snippet view article find links to article
infection. Additionally, they found similarities between the human innate immune system and the bacterial defense system against phages. It appears thatVirus-like particle (2,644 words) [view diff] case mismatch in snippet view article find links to article
"Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System". Vaccines. 6 (3): 37. doi:10.3390/vaccines6030037. PMC 6161069.Animal testing on invertebrates (899 words) [view diff] exact match in snippet view article find links to article
PMID 23535125. Schulenburg H, Kurz CL, Ewbank JJ (2004). "Evolution of the innate immune system: the worm perspective". Immunol. Rev. 198: 36–58. doi:10.1111/j.0105-2896Ken Raymond (1,306 words) [view diff] exact match in snippet view article find links to article
the project has begun to explore siderophore interactions with the innate immune system during bacterial infections. Throughout the years the iron projectOcular immune system (1,800 words) [view diff] exact match in snippet view article find links to article
that may contain microorganisms. Other components of the ocular innate immune system include tears, epithelial cells, keratocytes, corneal nerves, theInterleukin-1 receptor associated kinase (3,637 words) [view diff] exact match in snippet view article find links to article
Interleukin 1 is a cytokine that acts locally and systemically in the innate immune system. IL-1a and IL-1ß are known for causing inflammation, but can alsoAlpha-2-Macroglobulin (1,662 words) [view diff] exact match in snippet view article find links to article
(1999). "Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system". Developmental and Comparative Immunology. 23 (4–5): 375–390. doi:10Bifidobacterium (2,458 words) [view diff] exact match in snippet view article find links to article
"Potential of probiotics as biotherapeutic agents targeting the innate immune system" (PDF). African Journal of Biotechnology. February 2005. "Probiotics:Sujata Sharma (1,156 words) [view diff] exact match in snippet view article find links to article
of Peptidoglycan Recognition Protein which is a component of the innate immune system and are conserved from insects to mammals, have given a new directionMariana J. Kaplan (378 words) [view diff] exact match in snippet view article find links to article
significantly advanced the understanding of the pathogenic role of the innate immune system in systemic autoimmune diseases, atherosclerosis, and immune-mediatedAkiko Iwasaki (1,760 words) [view diff] exact match in snippet view article find links to article
; Medzhitov, R. (2010). "Regulation of adaptive immunity by the innate immune system". Science. 327 (5963): 291–295. Bibcode:2010Sci...327..291I. doi:10Tim Sparwasser (867 words) [view diff] exact match in snippet view article find links to article
DNA sequences containing specific CpG motifs activate cells of the innate immune system and can therefore be used as adjuvants in experimental vaccinationIFNK (2,561 words) [view diff] exact match in snippet view article find links to article
IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system". Journal of Immunology. 169 (9). Baltimore, Md.: 4822–4830. doi:10Animal heme-dependent peroxidases (877 words) [view diff] exact match in snippet view article find links to article
superfamily: Reconstructed evolution of critical enzymes of the innate immune system". Proteins. 72 (2): 589–605. doi:10.1002/prot.21950. PMID 18247411Vishva Dixit (3,466 words) [view diff] exact match in snippet view article find links to article
at the molecular level. During his tenure, he has worked on the innate immune system, particularly its role in orchestrating an inflammatory responseYu-Shan Lin (1,185 words) [view diff] exact match in snippet view article find links to article
17, 2018). "Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones". PLOS Biology. 16 (9):Immunology (4,206 words) [view diff] exact match in snippet view article find links to article
immunology. The immune system has been divided into a more primitive innate immune system and, in vertebrates, an acquired or adaptive immune system. The latterAutolysin (1,393 words) [view diff] exact match in snippet view article find links to article
cell surface peptidoglycan to prevent detection by the Drosophila innate immune system". eLife. 3: e02277. doi:10.7554/eLife.02277. PMC 3971415. PMID 24692449Margaret Ackerman (740 words) [view diff] exact match in snippet view article find links to article
HIV and Herpes simplex virus. Her vaccines look to make use of the innate immune system, the early response system that protects us from pathogens untilClouding of consciousness (2,821 words) [view diff] exact match in snippet view article find links to article
mold exposure. This may be due to mycotoxin exposure and consequent innate immune system activation and inflammation, including in the central nervous systemCurli (1,701 words) [view diff] exact match in snippet view article find links to article
(Pathogen-associated molecular pattern); its β-sheet structure is recognized in the innate immune system and activates the TLR2 (Toll-Like Receptor 2). This then causes aElina Zúñiga (2,559 words) [view diff] exact match in snippet view article find links to article
cells (mDCs). This change in phenotype and function enables the innate immune system with the enhanced ability to process and present antigens and recognizeZizania latifolia (1,020 words) [view diff] exact match in snippet view article find links to article
(Zizania latifolia) infected with Ustilago esculenta stimulates innate immune system, via induction of human β-defensin-2. ISHS Acta Horticulturae 841:Allergy to cats (2,477 words) [view diff] exact match in snippet view article find links to article
enters through the nose or mouth, antigen presenting cells of the innate immune system analyze the allergen and present antigenic peptides to helper T cellsTRAF3IP2 (1,139 words) [view diff] exact match in snippet view article find links to article
"Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection". PLOS ONE. 2 (7): e631. Bibcode:2007PLoSOTRIM14 (1,278 words) [view diff] exact match in snippet view article find links to article
cell show increased transcription of eighteen genes involved in the innate immune system. They are ifna, il6 (ifnb2), isg15, raf-1, NF-kB (nf-kb1, rela, nf-kb2Omptin (1,329 words) [view diff] exact match in snippet view article find links to article
bacteria produce proteases that can target components of the host's innate immune system. Omptin proteases function as a defense mechanism against antimicrobialRetinal gene therapy using lentiviral vectors (1,503 words) [view diff] exact match in snippet view article find links to article
the lentivirus, all of them falling under either activity by the innate immune system or adaptive immune system. In the cases of some HIV-1-derived lentiviralBjörn Dahlbäck (1,340 words) [view diff] exact match in snippet view article find links to article
"Complement inhibitor C4b-binding protein—friend or foe in the innate immune system?". Molecular Immunology. 40 (18): 1333–1346. doi:10.1016/j.molimmCoagulin (1,625 words) [view diff] exact match in snippet view article find links to article
reaction at the final stage of hemolymph coagulation is an important innate immune system of horseshoe crabs. In comparison, mammalian blood coagulation differsAcute generalized exanthematous pustulosis (2,729 words) [view diff] exact match in snippet view article find links to article
stimulation involves subverting the antigen presentation pathways of the innate immune system. A drug or metabolite covalently binds with a host protein to formSchreckstoff (3,605 words) [view diff] exact match in snippet view article find links to article
Marchant and D. P. Chivers. 2009. Epidermal club cells and the innate immune system of minnows. Proceedings of the Royal Society B 98:891-897. HamiltonLactobacillus acidophilus (3,318 words) [view diff] exact match in snippet view article find links to article
community, providing the organism with intestinal health benefits. The innate immune system of L. acidophilus also produces antimicrobial peptides. The groupGWAS in allergy (834 words) [view diff] exact match in snippet view article find links to article
receptors ( LTRs ) type, a family of proteins that form part of the innate immune system . These receptors are transmembrane and recognize molecular patternsGendered impact of the COVID-19 pandemic (10,380 words) [view diff] exact match in snippet view article find links to article
response to infections, and specifically to viruses. Alterations in the innate immune system, including the pattern recognition receptors, Toll-like receptorsInterleukin (4,194 words) [view diff] exact match in snippet view article find links to article
secreted and is an important mediator of the immune reaction in the innate immune system response. Interleukin 9 (IL-9) is a cytokine that supports IL-2 independentVincent Racaniello (2,583 words) [view diff] exact match in snippet view article find links to article
Racaniello has also begun to study how these viruses evade the host innate immune system, in particular interferon type I response. Infection of culturedBorrelia burgdorferi (4,080 words) [view diff] exact match in snippet view article find links to article
immune system that allow for rapid and long-lasting responses. The innate immune system allows for a rapid, non-specific response to a pathogen. While theAlveolar macrophage (3,913 words) [view diff] exact match in snippet view article find links to article
lipoglycans and lipoproteins that are recognized by cells of the innate immune system through the TLRs. Upon binding of PAMPs to TLRs, the TLR triggersList of enzymes (3,650 words) [view diff] exact match in snippet view article find links to article
Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, andWang Yanyi (1,526 words) [view diff] exact match in snippet view article find links to article
working on her thesis about pattern recognition signaling of the innate immune system as it relates to viruses, especially in regard to the Type 1 IFNMessenger RNA (6,206 words) [view diff] exact match in snippet view article find links to article
function of genes in cell culture. It is thought to be part of the innate immune system as a defense against double-stranded RNA viruses. MicroRNAs (miRNAs)Retinol (5,130 words) [view diff] exact match in snippet view article find links to article
mucosa through its metabolite, retinoic acid (RA). As part of the innate immune system, toll-like receptors in skin cells respond to pathogens and cellAutoimmunity (5,880 words) [view diff] exact match in snippet view article find links to article
classical autoimmune diseases at one extreme and diseases driven by the innate immune system at the other extreme. Within this scheme, the full spectrum of autoimmunityMammary gland (5,471 words) [view diff] exact match in snippet view article find links to article
Penninger, J. M. (2006). "Evolution of the mammary gland from the innate immune system?". BioEssays. 28 (6): 606–616. doi:10.1002/bies.20423. PMID 16700061Calprotectin (2,176 words) [view diff] exact match in snippet view article find links to article
organisms. Mammals strictly limit metal availability as a part of the innate immune system, and this helps prevent infection by microbes and fungi. CalprotectinMexican free-tailed bat (3,939 words) [view diff] exact match in snippet view article find links to article
McCracken, G. F. (2009). "Roosting ecology and variation in adaptive and innate immune system function in the Brazilian free-tailed bat (Tadarida brasiliensis)"Myocarditis (6,426 words) [view diff] exact match in snippet view article find links to article
apoptosis of cardiac muscle cells (myocytes) and activation of the innate immune system. Over the next 1–4 weeks, viral replication continues with subsequentGluten (6,936 words) [view diff] exact match in snippet view article find links to article
pathogenesis is not yet well understood, but the activation of the innate immune system, the direct negative effects of gluten and probably other wheat componentsList of human clusters of differentiation (492 words) [view diff] exact match in snippet view article find links to article
Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificityNovavax COVID-19 vaccine (5,773 words) [view diff] exact match in snippet view article find links to article
adjuvant demonstrates its protection against the virus by inducing innate immune system rapidly. At the local site of injection, the adjuvant recruits antigenPlasmodium berghei (2,679 words) [view diff] exact match in snippet view article find links to article
OCLC 742299021. Clayton AM, Dong Y, Dimopoulos G (2014). "The Anopheles innate immune system in the defense against malaria infection". Journal of Innate ImmunityStevens–Johnson syndrome (5,826 words) [view diff] exact match in snippet view article find links to article
this involves subverting the antigen presentation pathways of the innate immune system. The drug or metabolite covalently binds with a host protein to formT-cell receptor (5,378 words) [view diff] exact match in snippet view article find links to article
only when an infection or inflammatory stimulus is detected by the innate immune system, known as a "danger signal". This two-signal system makes sure thatGustav Gaudernack (2,281 words) [view diff] exact match in snippet view article find links to article
mouse myeloma protein λ315. He further became interested in the innate immune system, in particular monocytes, and generated monocyte-specific monoclonalMycobacterium tuberculosis (8,559 words) [view diff] exact match in snippet view article find links to article
"trained immunity", which refers to the enhanced response of the innate immune system. Unlike adaptive immunity, trained immunity involves long-lastingDouglas Scherr (2,302 words) [view diff] exact match in snippet view article find links to article
currently developing a novel class of compounds that utilize the innate immune system to fight urologic tumors. He is working on the development of a non-invasiveMonoclonal antibody therapy (4,217 words) [view diff] exact match in snippet view article find links to article
Monoclonal antibody therapy can aid the immune system because the innate immune system responds to the environmental factors it encounters by discriminatingInterleukin-1 family (6,093 words) [view diff] exact match in snippet view article find links to article
molecules in the context of altered pH, they are recognized by the innate immune system as molecules that should not be in extracellular space. Cell stressBile salt hydrolase (2,089 words) [view diff] exact match in snippet view article find links to article
Indirectly, bile acids shape the gut microbiota by regulating the innate immune system or activating cellular signaling machinery that excludes certainAspergillus fumigatus (4,593 words) [view diff] exact match in snippet view article find links to article
distribution in the environment. However, in healthy individuals, the innate immune system is an efficacious barrier to A. fumigatus infection. A large portionCd1-restricted T cell (1,585 words) [view diff] exact match in snippet view article find links to article
infected. Natural killer T (NKT) cells represent unusual cells of the innate immune system because they express a surface receptor that is generated by somaticUstilago esculenta (861 words) [view diff] exact match in snippet view article find links to article
(Zizania latifolia) infected with Ustilago esculenta stimulates innate immune system, via induction of human β-defensin-2. ISHS Acta Horticulturae 841:Mississippi gopher frog (2,997 words) [view diff] exact match in snippet view article find links to article
in its immune system that are unique to Rana sevosa. The frog's innate immune system is adept at recognizing outside prokaryotic pathogens. Rana sevosaBombus hortorum (2,968 words) [view diff] exact match in snippet view article find links to article
may affect the response to the parasite by triggering the bee's innate immune system, up-regulated effector genes that defend the host. Bombus hortorumPlant disease epidemiology (2,369 words) [view diff] exact match in snippet view article find links to article
signals. In responses to infections, plants have a two-branched innate immune system. The first branch has to recognize and respond to molecules thatMosquito-borne disease (6,955 words) [view diff] exact match in snippet view article find links to article
Mosquito-borne flaviviruses also encode viral antagonists to the innate immune system in order to cause persistent infection in mosquitoes and a broadHFE H63D gene mutation (2,659 words) [view diff] exact match in snippet view article find links to article
H63D syndrome patients experience nonspecific activation of the innate immune system, which can additionally lead to spontaneously occurring, passiveEbola vaccine (6,259 words) [view diff] exact match in snippet view article find links to article
doses of VP35. This challenge resulted in the activation of the innate immune system and the production of anti-EBOV antibodies. The primates were thenPlatelet (8,530 words) [view diff] exact match in snippet view article find links to article
Cox D, Kerrigan SW, Watson SP (June 2011). "Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation". Journal ofJonathan C. Kagan (3,468 words) [view diff] exact match in snippet view article find links to article
centers (SMOCs), which are considered the signaling organelles of the innate immune system. Kagan's lab has used synthetic biology to engineer the TLR-myddosomeHsp70 (5,785 words) [view diff] exact match in snippet view article find links to article
diseases like retinopathy, Toll like receptors are integral part of innate immune system and eHSP70 binds to toll like receptors and activates the MyD88 pathwayHantavirus pulmonary syndrome (5,913 words) [view diff] exact match in snippet view article find links to article
facilitate prolonged spread of the virus throughout the body. The innate immune system recognizes hantavirus infection by detection of viral RNA. This triggersAIM2 (2,826 words) [view diff] exact match in snippet view article find links to article
oligonucleotide/oligosaccharide binding (OB) folds. AIM2 is a component of the innate immune system that functions as a cytoplasmic dsDNA sensor playing a role in antiviralRhesus macaque (8,597 words) [view diff] exact match in snippet view article find links to article
influenza on a cellular level in each tissue. Both viruses stimulated innate immune system inflammation, but the 1918 flu stimulated stronger and more persistentLip licker's dermatitis (2,658 words) [view diff] exact match in snippet view article find links to article
damaged with the increased skin permeability. As the response of the innate immune system, proinflammatory cytokines are released facing the damage to theSurfactant protein A1 (3,387 words) [view diff] exact match in snippet view article find links to article
J (Jun 1997). "Collectins: collectors of microorganisms for the innate immune system". BioEssays. 19 (6): 509–18. doi:10.1002/bies.950190610. PMID 9204768Surface modification of biomaterials with proteins (3,306 words) [view diff] exact match in snippet view article find links to article
proteins surrounding the implant serve to "hide" the implant from the innate immune system. However, if the implant is coated in allergenic proteins, the patient'sAnimal testing (22,046 words) [view diff] exact match in snippet view article find links to article
early-stage discovery screens. Because of similarities between the innate immune system of insects and mammals, insects can replace mammals in some typesDrug rash with eosinophilia and systemic symptoms (4,307 words) [view diff] exact match in snippet view article find links to article
stimulation involves subverting the antigen presentation pathways of the innate immune system. The drug or metabolite covalently binds with a host protein to formBNIP3 (2,693 words) [view diff] exact match in snippet view article find links to article
death usually occurs with autophagy rather than by autophagy. The innate immune system is generally not known to exhibit memory traits, but emerging researchAgeing (12,275 words) [view diff] exact match in snippet view article find links to article
infection, due to over-activation and a decrease in the precision of the innate immune system dysbiosis of gut microbiome (e.g., loss of microbial diversity, expansionChemorepulsion (2,898 words) [view diff] exact match in snippet view article find links to article
Neutrophils are critical constituents of the innate immune systemCoeliac disease (15,863 words) [view diff] exact match in snippet view article find links to article
and involve the release of interleukin 15 and activation of the innate immune system by a shorter gluten peptide (p31–43/49). This would trigger killingStaphylococcus aureus (13,914 words) [view diff] exact match in snippet view article find links to article
S. aureus species as well as increased virulence via evading the innate immune system and optimising persistent infections.[citation needed] The list ofPaired receptors (3,057 words) [view diff] case mismatch in snippet view article find links to article
Eriko; McVicar, Daniel W. (May 2008). "Paired Receptor Systems of the Innate Immune System". Current Protocols in Immunology. 81 (1): Appendix-1X. doi:10.1002/0471142735William Federspiel (1,226 words) [view diff] exact match in snippet view article find links to article
designed to remove the chemical molecules that orchestrate the body's innate immune system. By 2012, ALung's clinical trials on the Hemolung found that theMilk (15,661 words) [view diff] exact match in snippet view article find links to article
MR, Penninger JM (2006). "Evolution of the mammary gland from the innate immune system?". BioEssays. 28 (6): 606–16. doi:10.1002/bies.20423. PMID 16700061Cellular adoptive immunotherapy (2,170 words) [view diff] exact match in snippet view article find links to article
expansion, efficacy, and persistence. Natural killer cells belong to the innate immune system, while they perform anti-tumor functions in a very similar mechanismSAAL1 (2,146 words) [view diff] exact match in snippet view article find links to article
protein-interaction network of interferon-stimulated genes extends the innate immune system landscape". Nature Immunology. 20 (4): 493–502. doi:10.1038/s41590-019-0323-3Chinese red-headed centipede (4,127 words) [view diff] exact match in snippet view article find links to article
leads to the development of numerous antimicrobial peptides in its innate immune system. An antimicrobial peptide named scolopendrasin VII was discoveredCD4+ T cells and antitumor immunity (4,000 words) [view diff] exact match in snippet view article find links to article
granzymes into an infected cell. (Abbas and Lichtman, 2005) Finally, the innate immune system has also been associated with immunosurveillance (Dunn et al., 2004)Nicotine (14,454 words) [view diff] exact match in snippet view article find links to article
other cognitive symptoms of schizophrenia. Immune cells of both the innate immune system and adaptive immune systems frequently express the α2, α5, α6, α7CRISPR (11,900 words) [view diff] exact match in snippet view article find links to article
ancestral effector module, which likely functioned as an independent innate immune system. The highly conserved cas1 and cas2 genes of the adaptor module evolvedHantavirus hemorrhagic fever with renal syndrome (7,271 words) [view diff] exact match in snippet view article find links to article
facilitate prolonged spread of the virus throughout the body. The innate immune system recognizes hantavirus infection by detection of viral RNA. This triggersCohesin (6,843 words) [view diff] exact match in snippet view article find links to article
macrophages leads to impairment of inflammatory response of the innate immune system and restricts transcriptional response of primary macrophages toUlcerative colitis (16,298 words) [view diff] exact match in snippet view article find links to article
patients in clinical remission, indicating the involvement of the innate immune system in the etiology. Fexofenadine, an antihistamine drug used in treatmentMorphine (14,053 words) [view diff] exact match in snippet view article find links to article
One study successfully showed that dendritic cells, part of the innate immune system, display opiate receptors. Dendritic cells are responsible for producingToxoplasma gondii (12,717 words) [view diff] exact match in snippet view article find links to article
gondii infection stimulates production of IL-2 and IFN-γ by the innate immune system. Continuous IFN-γ production is necessary for control of both acuteJochen Reiser (1,713 words) [view diff] exact match in snippet view article find links to article
(CKD) as well as for acute kidney injury (AKI). suPAR may link the innate immune system functionally to the kidney – a novel, potentially fundamental conceptVirtual colony count (4,186 words) [view diff] exact match in snippet view article find links to article
example, defensins are antimicrobial peptides that are part of the innate immune system of many organisms including humans. They are divided into severalZebrafish (12,480 words) [view diff] exact match in snippet view article find links to article
used as a model organism to study vertebrate innate immunity. The innate immune system is capable of phagocytic activity by 28 to 30 h postfertilizationContact dermatitis (2,856 words) [view diff] exact match in snippet view article find links to article
contact dermatitis. This disrupts the skin barrier and activates the innate immune system. Keratinocytes in the epidermis can be actually affected by irritantsPostural orthostatic tachycardia syndrome (9,953 words) [view diff] exact match in snippet view article find links to article
have been identified in small cohorts of POTS patients. Signs of innate immune system activation with elaboration of pro-inflammatory cytokines has alsoSelective serotonin reuptake inhibitor (16,564 words) [view diff] exact match in snippet view article find links to article
are a subset of immune cells responsible for host defense in the innate immune system. Macrophages can release cytokines and other chemicals to cause anDonald F. Weaver (1,221 words) [view diff] exact match in snippet view article find links to article
"Amyloid beta is an early responder cytokine and immunopeptide of the innate immune system". Alzheimer's & Dementia: Translational Research & Clinical InterventionsFrances Platt (2,602 words) [view diff] exact match in snippet view article find links to article
1016/s0140-6736(00)02161-9 A pivotal study showing that activation of the innate immune system is a common hallmark of lysosomal disorders of the brain and a newOzone (18,252 words) [view diff] exact match in snippet view article find links to article
immune protection. Neutrophils, another important cell type of the innate immune system that primarily targets bacterial pathogens, are found to be presentSarah Tabrizi (3,638 words) [view diff] exact match in snippet view article find links to article
cellular degeneration in prion disease, identified a key role for the innate immune system in the pathogenesis of Huntington’s disease, published the firstCarcinogenesis (13,994 words) [view diff] exact match in snippet view article find links to article
KM, Cidlowski JA (November 2011). "Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome". The Journal of BiologicalLeptin (13,127 words) [view diff] exact match in snippet view article find links to article
leptin/leptin receptors in modulation of T cell activity and the innate immune system was shown in experimentation with mice. It modulates the immune responseSputnik V COVID-19 vaccine (13,917 words) [view diff] exact match in snippet view article find links to article
adjuvants due to the presence of viral components that stimulate the innate immune system. "Голикова назвала сроки выпуска первых партий вакцин НИЦ ГамалеиEpigenetic clock (7,305 words) [view diff] exact match in snippet view article find links to article
T-cell function and the complement system, a key component of the innate immune system where it promotes inflammation ATP8B4: encodes for a lipid transporterReproductive immunology (4,976 words) [view diff] exact match in snippet view article find links to article
immune attack. While natural killer cells (NK cells), part of the innate immune system, are cytotoxic and responsible for attacking pathogens and infectedMicrobiome (11,925 words) [view diff] exact match in snippet view article find links to article
host and microbes and recognition of the consortia by the worm's innate immune system. The major strength of this system is that it does offer the abilityHigh-dose chemotherapy (4,283 words) [view diff] exact match in snippet view article find links to article
having a higher incidence of infections. Genetic differences in the innate immune system may also affect the duration and severity of infectious episodesMendel Lectures (857 words) [view diff] case mismatch in snippet view article find links to article
Cambridge Institute, University of Cambridge, UK "A Small RNA-based Innate Immune System Guards the Integrity of Germ Cell Genomes" 15 106 March 8, 2018 ElenaSiderocalin (3,390 words) [view diff] exact match in snippet view article find links to article
RK (Aug 2009). "Siderocalins: siderophore-binding proteins of the innate immune system" (PDF). Biometals. 22 (4): 557–64. doi:10.1007/s10534-009-9207-6Bacteroides thetaiotaomicron (4,665 words) [view diff] exact match in snippet view article find links to article
IL-10. T-cells are stimulated by IL-10 and is expressed via the innate immune system through macrophages and DC. B. thetaiotaomicron OMVs in individualsTrypanosoma brucei (12,738 words) [view diff] exact match in snippet view article find links to article
and T. evansi) is not human infective because it is susceptible to innate immune system 'trypanolytic' factors present in the serum of some primates, includingPhage therapy (13,088 words) [view diff] exact match in snippet view article find links to article
bacteriophages can induce an immune response. Macrophages, key cells of the innate immune system, play a central role in mediating this response. The most frequentMedical textiles (4,698 words) [view diff] exact match in snippet view article find links to article
most permanent synthetic biomaterials are considered foreign by the innate immune system. This can lead to a foreign body reaction when implanted. ProductsMilk fat globule membrane (6,355 words) [view diff] exact match in snippet view article find links to article
S2CID 1964967. Newburg DS (April 2009). "Neonatal protection by an innate immune system of human milk consisting of oligosaccharides and glycans". JournalMarine microbiome (8,073 words) [view diff] exact match in snippet view article find links to article
host and microbes and recognition of the consortia by the worm's innate immune system. The major strength of this system is that it does offer the abilityMultiple sclerosis drug pipeline (9,437 words) [view diff] exact match in snippet view article find links to article
that blocks cell replication and immune responses, It targets the innate immune system (mast cells and microglia) and has shown efficacy in the progressiveAnticancer gene (6,791 words) [view diff] exact match in snippet view article find links to article
of apoptosis. This defensin traditionally works as a part of the innate immune system, working as an antimicrobial defense. However, this peptide is currentlyType IX secretion system (2,047 words) [view diff] exact match in snippet view article find links to article
other pathogen-associated molecular patterns (PAMPs), by a host's innate immune system, resulting in complement cascades. These plasma proteins meet thePaucimannosylation (6,235 words) [view diff] exact match in snippet view article find links to article
Paucimannosidic glycans were suggested to play roles in the nematodal innate immune system by impacting the nematode's ability to fight and survive pathogenicLactobacillus vaccine (10,570 words) [view diff] exact match in snippet view article find links to article
the lumen into mucosal tissues. This minimizes activation of the innate immune system, a process termed "immune exclusion". Furthermore, the selective