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searching for CRISPR 274 found (695 total)

alternate case: cRISPR

Functional genomics (3,747 words) [view diff] exact match in snippet view article find links to article

strength of putative enhancers are assayed by this method. Perturb-seq couples CRISPR mediated gene knockdowns with single-cell gene expression. Linear models
Editas Medicine (1,156 words) [view diff] exact match in snippet view article find links to article
clinical-stage biotechnology company which is developing therapies based on CRISPR–Cas9 gene editing technology. Editas is based in Cambridge, Massachusetts
CRISPR Therapeutics (472 words) [view diff] exact match in snippet view article find links to article
CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug. In fiscal year 2019, the company had revenues of $289.59 million
Vertex Pharmaceuticals (3,115 words) [view diff] exact match in snippet view article find links to article
acquire Exonics Therapeutics for up to $1 billion and collaborate with CRISPR Therapeutics, boosting its development of treatments for Duchenne muscular
Eradication of suffering (1,360 words) [view diff] exact match in snippet view article find links to article
varying degrees of pleasure. The development of gene editing techniques like CRISPR has raised the prospect that "scientists can identify the causes of certain
Tristromaviridae (728 words) [view diff] exact match in snippet view article find links to article
evolved from a Cas4 endonuclease, a conserved component of the adaptive CRISPR-Cas immunity, presenting the first described case of exaptation of an enzyme
Colitis (1,073 words) [view diff] exact match in snippet view article find links to article
suggesting some patients may benefit from an elimination diet. In the lab, the CRISPR-Cas systems effectively killed C. difficile bacteria. Researchers tested
Chen Hu (physician) (706 words) [view diff] exact match in snippet view article
In 2017, he and Deng Hongkui engineered resistance to HIV in mice using CRISPR gene editing, and for the first time used the technique on an AIDS patient
Deng Hongkui (647 words) [view diff] exact match in snippet view article find links to article
hepatitis C. In 2017, he and Chen Hu engineered resistance to HIV in mice using CRISPR gene editing, and for the first time used the technique on an AIDS patient
Nobel Prize in Chemistry (2,203 words) [view diff] exact match in snippet view article find links to article
Jennifer A. Doudna for the development of a method for genome editing known as CRISPR Cas-9 – the first time that two women have jointly won the Nobel Prize in
Pandemic (Cook novel) (162 words) [view diff] exact match in snippet view article
thriller novel by Robin Cook. The book centers around the molecule called CRISPR/Cas9, which can be custom-tailored to find and alter genes in living organisms
LEAPER gene editing (785 words) [view diff] exact match in snippet view article find links to article
University in 2019, the technique, some have claimed, is more efficient than the CRISPR gene editing technique. Initial studies have claimed that editing efiiciencies
Janice Chen (794 words) [view diff] exact match in snippet view article find links to article
in even asymptomatic coronavirus patients. Founded in 2017, Mammoth uses CRISPR as a genetic “search engine” to alert researchers of disease markers it
Andrea Crisanti (scientist) (1,068 words) [view diff] exact match in snippet view article
decreasing malaria incidence. In 2018, Crisanti and colleagues demonstrated that CRISPR/Cas9 can be programmed to attack a conserved region of the sex determination
Rachel Haurwitz (505 words) [view diff] exact match in snippet view article find links to article
Haurwitz is the company's CEO and president. She holds several patents for CRISPR-based technologies. The firm was initially housed in the basement of the
Prime editing (1,653 words) [view diff] exact match in snippet view article find links to article
similar methodologies to precursor genome editing technologies, including CRISPR/Cas9 and base editors. As of 2019, it remains a scientific proof of concept
Krüppel associated box (787 words) [view diff] exact match in snippet view article find links to article
be a common property of the domain. KRAB domains can be fused with dCas9 CRISPR tools to form even stronger repressors. The KRAB domain had initially been
IRAK3 (708 words) [view diff] exact match in snippet view article find links to article
encoded by the IRAK3 gene. Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for
De-extinction (5,113 words) [view diff] exact match in snippet view article find links to article
has been rapidly advancing with the help of the CRISPR/Cas systems, particularly CRISPR/Cas9. The CRISPR/Cas9 system was originally discovered as part of
Insert (molecular biology) (1,356 words) [view diff] exact match in snippet view article
S phases in the cell cycle. CRISPR gene editing based on Clustered regularly interspaced short palindromic repeats (CRISPR) -Cas9 is an enzyme that uses
Yield10 Bioscience (1,270 words) [view diff] exact match in snippet view article find links to article
has had a gene disrupted using CRISPR/Cas9 gene editing technology, resulting in the desired phenotype. The use of CRISPR technology for this purpose could
Saccharomyces boulardii (1,709 words) [view diff] exact match in snippet view article find links to article
grows at 37 °C (98.6 °F). In addition, the popular genome-editing tool CRISPR-Cas9 was proven to be effective in S. boulardii. Boulard first isolated
Duchenne muscular dystrophy (6,182 words) [view diff] exact match in snippet view article find links to article
Duchenne muscular dystrophy (DMD). Researchers used a technique called CRISPR/Cas9-mediated genome editing, which can precisely remove a mutation in the
Organoid (6,861 words) [view diff] exact match in snippet view article find links to article
identify possible treatments. In one example, the genome editing system called CRISPR was applied to human pluripotent stem cells to introduce targeted mutations
Cancer Genome Project (1,673 words) [view diff] exact match in snippet view article find links to article
to patients. The different types of genetic screens being used include CRISPR, chemical mutagenesis, and RNAi. The main areas of focus by the group involve
Cancer Genome Project (1,673 words) [view diff] exact match in snippet view article find links to article
to patients. The different types of genetic screens being used include CRISPR, chemical mutagenesis, and RNAi. The main areas of focus by the group involve
Matthew Porteus (197 words) [view diff] exact match in snippet view article find links to article
Matthew Porteus". CRISPR Therapeutics. Retrieved 23 June 2021. "There Are Now Two Pushes to Treat Sickle Cell Disease With CRISPR". CRISPR Medicine News.
Umeå (2,159 words) [view diff] exact match in snippet view article find links to article
with two universities and over 39,000 enrolled students.[citation needed] CRISPR gene editing was developed by researchers at Umeå University, being awarded
Broad Institute (1,985 words) [view diff] exact match in snippet view article find links to article
of DNA-templated synthesis, phage-assisted directed evolution and Cas9/CRISPR base-editing. Aviv Regev is a computational biologist with interests in
Kim Jin-soo (biologist) (826 words) [view diff] exact match in snippet view article
of ToolGen; a company he founded. ToolGen is a biotech company based on CRISPR technology focusing on human therapies, and molecular breeding in plants
FokI (599 words) [view diff] exact match in snippet view article find links to article
95.18.10570. PMC 27935. PMID 9724744. Tsai, S. Q. et al. (2014). Dimeric CRISPR RNA-guided Fok1 nucleases for highly specific genome editing. Nature Biotechnol
Anopheles (5,347 words) [view diff] exact match in snippet view article find links to article
proposals to eradicate Anopheles gambiae, the main vector for malaria, with a CRISPR-Cas9 gene drive system. This system aims to eradicate the species through
J. Keith Joung (759 words) [view diff] exact match in snippet view article find links to article
TAL effector, TALENs, and the RNA-guided CRISPR/Cas9 system. In addition to demonstrating the use of the CRISPR/Cas9 system in vivo through the zebrafish
HIV/AIDS research (3,697 words) [view diff] exact match in snippet view article find links to article
cell therapies. Excision is a biotechnology company with a first-in-human CRISPR-based one-time gene therapy to be evaluated in individuals with HIV. Research
Biological warfare (9,234 words) [view diff] exact match in snippet view article find links to article
technique called Clustered, Regularly Interspaced, Short Palindromic Repeat (CRISPR-Cas9) is now so cheap and widely available that scientists fear that the
SLC45A4 (235 words) [view diff] exact match in snippet view article find links to article
K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature
Nature's 10 (1,339 words) [view diff] exact match in snippet view article find links to article
Haile-Selassie: Origin seeker Wendy Rogers: Transplant ethicist Deng Hongkui: CRISPR translator John M. Martinis: Quantum builder Greta Thunberg: Climate catalyst
GUIDE-Seq (831 words) [view diff] exact match in snippet view article find links to article
in vitro detection of off-target genome editing events in DNA caused by CRISPR/Cas9 as well as other RNA-guided nucleases in living cells. Similar to LAM-PCR
Maneesha S. Inamdar (1,370 words) [view diff] exact match in snippet view article find links to article
embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-39". Stem Cell Research. 16 (2): 308–310. doi:10
Hertz Nazaire (289 words) [view diff] exact match in snippet view article find links to article
work for Sickle-cell disease around the world, and he supports the use of CRISPR for gene therapy. He is also a published author of an adult coloring book
Missense mRNA (1,012 words) [view diff] exact match in snippet view article find links to article
substitutions, novel technologies that co-inject gRNA and hCas9 mRNA of the CRISPR/Cas9 system, in conjunction with single-strand oligodeoxynucleotide (ssODN)
Senolytic (1,448 words) [view diff] case mismatch in snippet view article find links to article
lysosomal β-galactosidase (a common senescence marker) Crispr/Cas9 BIRC5 Gene Knockout: Crispr/Cas9 is used to trigger apoptosis in relation to a specified
Xenopus (6,025 words) [view diff] exact match in snippet view article find links to article
syndrome) and Megalencephalic leukoencephalopathy. Gene editing by the CRISPR/CAS system has recently been demonstrated in Xenopus tropicalis and Xenopus
Red flour beetle (2,471 words) [view diff] exact match in snippet view article find links to article
experiments. CRISPR technology has been shown to be useful in studying Tribolium castaneum. In one experiment, researchers used CRISPR to knock out the
Sickle cell disease (13,550 words) [view diff] exact match in snippet view article find links to article
a few more people being treated since then. Gene editing platforms like CRISPR/Cas9 have been used to correct the disease-causing mutation in hematopoietic
Eugenics (9,461 words) [view diff] exact match in snippet view article find links to article
revival in bioethical discussions on the usage of new technologies such as CRISPR and genetic screening, with a heated debate on whether these technologies
Kiran Musunuru (1,164 words) [view diff] exact match in snippet view article find links to article
diseases, and is a leading expert in genome-editing techniques, particularly CRISPR-Cas9. His lab was the first to develop an efficient technique to genetically
Kiran Musunuru (1,164 words) [view diff] exact match in snippet view article find links to article
diseases, and is a leading expert in genome-editing techniques, particularly CRISPR-Cas9. His lab was the first to develop an efficient technique to genetically
Michael S. Gilmore (409 words) [view diff] exact match in snippet view article find links to article
was named by Eric Lander in “The Heroes of CRISPR”3 as inspiring Broad Institute interest in developing CRISPR as a tool for therapeutic gene editing. Mike
Ellen R. Sandor (979 words) [view diff] exact match in snippet view article find links to article
scientific phenomena such as the AIDS virus, Neutrinos, Microglia, and CRISPR. Sandor holds a B.A. from Brooklyn College (1963) and an MFA in sculpture
Myostatin-related muscle hypertrophy (620 words) [view diff] exact match in snippet view article find links to article
H, Wei S, et al. (December 2015). "Generation of gene-target dogs using CRISPR/Cas9 system". Journal of Molecular Cell Biology. 7 (6): 580–3. doi:10.1093/jmcb/mjv061
Niren Murthy (438 words) [view diff] exact match in snippet view article find links to article
is a co-founder and scientific advisor for Genedit Inc., the inventor of CRISPR-Gold and the scientific co-founder of Microbial Medical. In addition, BioAmp
Burkholderia cenocepacia (1,126 words) [view diff] exact match in snippet view article find links to article
mitochondria – for which a team at the Broad Institute developed a new kind of CRISPR-free base editor, called DdCBE, using the toxin. See also: Burkholderia
Bioterrorism (8,487 words) [view diff] exact match in snippet view article find links to article
Jennifer (2015-11-09). "The Crispr Quandary". The New York Times. Retrieved 2016-01-24. Ledford, Heidi (2015-06-01). "CRISPR, the disruptor". Nature. 522
Familial amyloid polyneuropathy (1,176 words) [view diff] exact match in snippet view article find links to article
amyloidosis with polyneuropathy were given doses of NTLA-2001, based on a CRISPR gene editing system. Researchers reported mild adverse events and decreases
Monoclonal antibody (4,566 words) [view diff] exact match in snippet view article find links to article
production of recombinant monoclonal antibodies involves repertoire cloning, CRISPR/Cas9, or phage display/yeast display technologies. Recombinant antibody
Transformation (genetics) (6,783 words) [view diff] exact match in snippet view article
button mushroom strain edited with CRISPR/CAS9 to prevent fruit body browning causing a broad discussion about placing CRISPR/CAS9-edited crops on the market
Horizontal Environmental Genetic Alteration Agents (1,434 words) [view diff] exact match in snippet view article find links to article
of infected individuals through sequence-specific editing systems like CRISPR, ZFNs or TALENs. No known infectious agent naturally has the capacity to
Sean Parker (5,655 words) [view diff] exact match in snippet view article find links to article
T-cells engineered using the CRISPR gene-editing technology. The trial was the first in the United States to test CRISPR-modified cells in humans. The
Christine Merlin (2,479 words) [view diff] exact match in snippet view article find links to article
locus. In 2016, Merlin and colleagues demonstrated that both TALENs and CRISPR/Cas9 technologies could be utilized in a similar manner to create highly
Max Perutz Labs (381 words) [view diff] exact match in snippet view article find links to article
Life Sciences and the 2020 Nobel Prize in Chemistry for her work on the CRISPR/Cas9 system, done partly in Vienna. As of June 2019, scientists of the Max
Hyperphosphatasia with mental retardation syndrome (591 words) [view diff] case mismatch in snippet view article find links to article
A mouse model that mirroring the human phenotype has been engineered by Crispr-Cas technology and is available for compound screening. Mabry CC, Bautista
Fluorine-18 (714 words) [view diff] exact match in snippet view article find links to article
modality PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. The dual-modality small molecule
Penicillium chrysogenum (1,387 words) [view diff] exact match in snippet view article find links to article
copies of the penicillin gene cluster. Similar to other filamentous fungi, CRISPR/Cas9-based genome editing techniques are available for editing the genome
Flagship Pioneering (420 words) [view diff] exact match in snippet view article find links to article
technology. In 2013, Flagship helped fund the creation of Editas Medicine to use CRISPR gene editing for the development of pharmacological therapies, originally
Gene cassette (1,314 words) [view diff] exact match in snippet view article find links to article
genetic elements. The usage of CRISPR/Cas9 systems has shown success in inserting genes into eukaryotic genomes. While CRISPR modification is still in its
FGF8 (2,154 words) [view diff] exact match in snippet view article find links to article
FGF8 has been documented to play a role in oralmaxillogacial diseases and CRISPR-cas9 gene targeting on FGF8 may be key in treating these diseases. Cleft
Thermoascus (344 words) [view diff] exact match in snippet view article find links to article
as an Agrobacterium tumefaciens-mediated transformation protocol and a CRISPR-Cas9 gene editing system, which have been used to overexpress genes that
2021 in science (29,969 words) [view diff] exact match in snippet view article find links to article
June – The first, small clinical trial of CRISPR gene editing in which a – lipid nanoparticle formulated – CRISPR (with mCas9) gene editing therapeutic is
Dickson Prize (1,382 words) [view diff] exact match in snippet view article find links to article
"Nanotechnology: Small Things Matter") 2018 Jennifer Doudna (February 1, 2018: "CRISPR Systems: Nature's Toolkit for Genome Editing") 2019 Emery N. Brown (January
Microbiology Society Prize Medal (257 words) [view diff] exact match in snippet view article find links to article
sub-surface biogeochemistry 2019 Jennifer Doudna discovery and developing CRISPR-Cas tools (Lecture given by Christof Fellman) 2020 Martin Blaser the human
Don Merton (2,093 words) [view diff] exact match in snippet view article find links to article
genetic diversity). With technological advances in genome mapping tools like CRISPR, scientists have successfully mapped all of the 147 Kakapo genomes, and
C11orf53 (545 words) [view diff] exact match in snippet view article find links to article
in acidic conditions, which are typical of the tumor microenvironment. CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made
Modifications (genetics) (1,070 words) [view diff] exact match in snippet view article
that no detriments are caused to the organism due to the new modification. CRISPR methods are a specific variation of the aforementioned process of genome
NIMPLY gate (136 words) [view diff] exact match in snippet view article find links to article
gates Fussenegger, Martin; Bojar, Daniel; Kim, Hyojin (9 April 2019). "A CRISPR/Cas9-based central processing unit to program complex logic computation
Reiko Kuroda (445 words) [view diff] exact match in snippet view article find links to article
determined at very early stages of of snail development. Her team later used CRISPR genetic editing to show that this process is dependent on a single gene
In vitro maturation (4,392 words) [view diff] exact match in snippet view article find links to article
of transgenic animals using innovative gene-editing techniques such as CRISPR/Cas9, TALENs and ZFNs for biomedical research. An example includes genetically
Public participation (decision making) (2,307 words) [view diff] exact match in snippet view article
society less highly. For example, a 2016-2017 survey of public opinion on CRISPR gene editing technology showed a “relatively broad consensus among all groups
Molecular Infection Medicine Sweden (397 words) [view diff] exact match in snippet view article find links to article
was the driving force behind the discovery of the mechanisms behind the CRISPR-Cas9 system. MIMS web page – www.mims.umu.se UCMR web page – www.ucmr.umu
Hachimoji DNA (1,482 words) [view diff] exact match in snippet view article find links to article
Science Earliest known life forms Extraterrestrial life Human Nature (2019 CRISPR film documentary) Hypothetical types of biochemistry Nucleic acid analogue
Cas (152 words) [view diff] exact match in snippet view article find links to article
Conditional access system, content protection for digital television Cas9, a CRISPR associated protein This disambiguation page lists articles associated with
Icahn Genomics Institute (1,620 words) [view diff] exact match in snippet view article find links to article
new types of treatments that utilize DNA and RNA based therapies, such as CRISPR, siRNA, RNA vaccines, and CAR T cells, and searching for novel drug targets
Jason Sheltzer (651 words) [view diff] exact match in snippet view article find links to article
as an independent fellow at Cold Spring Harbor Laboratory. Sheltzer uses CRISPR/Cas9 technology to study aneuploidy and cancer genomics. Through the use
Wild-type transthyretin amyloid (1,222 words) [view diff] exact match in snippet view article find links to article
study has demonstrated that NTLA-2001, a therapeutic agent based on the CRISPR-Cas9 system, induces targeted knockout of the transthyretin protein. Because
Japan Prize (710 words) [view diff] exact match in snippet view article find links to article
bacterial immune system CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas and the creation of the CRISPR-Cas9 genome editing system
Oregon Health & Science University (2,933 words) [view diff] case mismatch in snippet view article find links to article
Northwest opened in Lebanon, Oregon. The world's first in-vivo use of the Crispr-Cas9 DNA editing tool was conducted in 2020 at the Casey Eye Institute at
Jeffrey Leiden (1,719 words) [view diff] exact match in snippet view article find links to article
21, 2019. In 2015 Leiden established a collaboration between Vertex and CRISPR Therapeutics that led to the discovery and development of CTX001, the first
Coroner (TV series) (867 words) [view diff] case mismatch in snippet view article
Motion Brathwaite January 13, 2020 (2020-01-13) 351416-14 956,000 11 3 "Crispr Sistr" Winnifred Jong Nathalie Younglai January 20, 2020 (2020-01-20) 351416-15
Narrow-spectrum antibiotic (223 words) [view diff] exact match in snippet view article find links to article
Agents". MedChemComm. 9: 12–21. doi:10.1039/c7md00528h. PMC 5839511. PMID 29527285. Repurposing CRISPR-Cas systems as DNA-based smart antimicrobials v t e
Somatic cell (1,136 words) [view diff] exact match in snippet view article find links to article
1095/biolreprod.112.103481. PMC 4434944. PMID 23153565. "Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease". Retrieved 5 July 2018
Warren Alpert Foundation Prize (372 words) [view diff] exact match in snippet view article find links to article
org/prize-recipients https://warrenalpert.org/prize-recipients "Alpert Prize Recognizes CRISPR Pioneers". Warren Alpert Foundation. Retrieved 10 March 2016. "2015 Waren
Zachary Lippman (547 words) [view diff] exact match in snippet view article find links to article
S2CID 52919995. "CRISPR could bring groundcherries to market". October 2018. Greenwood, Veronique (5 October 2018). "Taming the Groundcherry: With Crispr, a Fussy
Hydroxycarboxylic acid receptor 3 (762 words) [view diff] exact match in snippet view article find links to article
Enten, JF; Lambert, NA; Isom, DG (9 June 2020). "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand
Aedes aegypti (3,611 words) [view diff] exact match in snippet view article find links to article
interrupting the reproductive cycle of these animals. The recent invention of CRISPR/Cas9 based genome editing tool have significantly expanded the scope of
Transhuman (1,389 words) [view diff] exact match in snippet view article find links to article
plausible. Similar commentary later occurred from gamers with the advent of CRISPR gene editing. Transhumans also have played a major role in the Star Trek
Nav1.7 (3,350 words) [view diff] exact match in snippet view article find links to article
antagonists. In 2021, researchers described a novel approach, developing a CRISPR-dCas9 epigenome editing method for a potential treatment of chronic pain
Human genetic enhancement (1,742 words) [view diff] exact match in snippet view article find links to article
created. By using clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9, a gene editing technique, they disabled a gene called CCR5 in the
Trypanosomiasis (919 words) [view diff] exact match in snippet view article find links to article
component in an effort to eradicate the disease. New technologies such as CRISPR allowing cheaper and easier genetic engineering could allow for such measures
Friedreich's ataxia (4,341 words) [view diff] exact match in snippet view article find links to article
frataxin expression and prevent DNA damage in human and mouse fibroblasts. CRISPR Therapeutics received a grant from the Friedreich's Ataxia Research Alliance
Gardnerella vaginalis (1,133 words) [view diff] exact match in snippet view article find links to article
Milda; Zilnyte, Milda; Zvirbliene, Aurelija (2012). "Insights into the CRISPR/Cas system of Gardnerella vaginalis". BMC Microbiology. 12: 301. doi:10
With great power comes great responsibility (1,761 words) [view diff] exact match in snippet view article find links to article
Independent. Retrieved 28 April 2019. Eskander, Veronica (26 April 2019). "Is CRISPR really a gene-ius discovery?". The Daily Campus. Retrieved 28 April 2019
Ralph L. Brinster (3,822 words) [view diff] exact match in snippet view article find links to article
and injection strategies developed by Brinster serve as the basis for the CRISPR/Cas9 system of genetic modification currently used for all types of gene
Methanopyrus (964 words) [view diff] exact match in snippet view article find links to article
reveal the order of tRNA processing events and the maturation of C/D box and CRISPR RNAs in the hyperthermophile Methanopyrus kandleri". Nucleic Acids Research
PARP inhibitor (1,757 words) [view diff] exact match in snippet view article find links to article
Song F, Aleksandrov R, et al. (May 2018). "Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance"
Thermus aquaticus (1,508 words) [view diff] exact match in snippet view article find links to article
chromosome and four plasmids, and its complete genome sequencing revealed CRISPR genes at numerous loci. Thermus aquaticus is generally of cylindrical shape
Endogenous retrovirus (7,074 words) [view diff] exact match in snippet view article find links to article
and to be passed into offspring, until the year 2017, when one lab, using CRISPR-Cas9, removed all 62 retroviruses from the pig genome. The consequences
Tracey Gloster (667 words) [view diff] exact match in snippet view article find links to article
Whitaker, R., Gloster, T. & White, M., (2020) An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity Nature. 577 7791 572-575 Gloster, T. M.
John Scott Medal (415 words) [view diff] exact match in snippet view article find links to article
research Masatoshi Nei evolutionary theory 2016 Emmanuelle Charpentier CRISPR-Cas genome editing Jennifer Doudna Feng Zhang Carl H. June cancer immunology
2020 in science (32,571 words) [view diff] exact match in snippet view article find links to article
diseases successfully treated with CRISPR". New Scientist. Retrieved 1 July 2020. "More early data revealed from landmark CRISPR gene editing human trial". New
Myosin binding protein C, cardiac (8,709 words) [view diff] exact match in snippet view article find links to article
editing to correct a mutation by CRISPR/Cas9 technology. Naturally existing as part of the prokaryotic immune system, the CRISPR/Cas9 system has been used for
Polypyrimidine tract-binding protein (244 words) [view diff] exact match in snippet view article find links to article
Zhou C, Li H, Chen Z, et al. (April 2020). "Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice". Cell. 181 (3):
Embryo (3,065 words) [view diff] exact match in snippet view article find links to article
attempted - see He Jiankui affair) genetic editing of human embryos via CRISPR-Cas9 as a potential avenue for preventing disease; however, this has been
DNA‐templated organic synthesis (249 words) [view diff] exact match in snippet view article find links to article
forward in DNA base editing We’ve evolved an even more powerful form of CRISPR gene editing Koblan, LW; Doman, JL; Wilson, C; Levy, JM; Tay, T; Newby,
Micropeptide (3,880 words) [view diff] no match in snippet view article find links to article
Micropeptides (also referred to as microproteins) are polypeptides with a length of less than 100-150 amino acids that are encoded by short open reading
New Breeding Techniques (970 words) [view diff] exact match in snippet view article find links to article
(three tools are used to achieve this: Zinc finger nuclease; TALENs, and CRISPR/Cas Tools) Genome editing to introduce changes to just a few base pairs
Low-density lipoprotein (5,009 words) [view diff] exact match in snippet view article find links to article
a mean dose of 2.15 gram per day. In 2021, scientists demonstrated that CRISPR gene editing can decrease blood levels of LDL cholesterol in vivo in Macaca
Vence L. Bonham Jr. (1,935 words) [view diff] exact match in snippet view article find links to article
developing country. With the emergence of gene editing technologies such as CRISPR, Bonham has emphasized that SCD is a critical example of the value of respect
Evolution of the brain (4,749 words) [view diff] exact match in snippet view article find links to article
the archaic gene variant NOVA1 present in Neanderthals and Denisovans via CRISPR-Cas9 shows that it has a major impact on neurodevelopment and that such
Wolf Prize in Medicine (228 words) [view diff] exact match in snippet view article find links to article
Emmanuelle Charpentier  France for deciphering and repurposing the bacterial CRISPR/Cas9 immune system for genome editing. Jennifer Doudna  United States for
New England Biolabs (2,015 words) [view diff] exact match in snippet view article find links to article
signed an agreement with ERS Genomics Limited that gave NEB rights to sell CRISPR/Cas9 tools and reagents, used for gene editing. The NEBuilder HiFi DNA Assembly
Joyce Van Eck (341 words) [view diff] exact match in snippet view article find links to article
Generation Using the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-Associated9 System". Plant Physiology. 166 (3): 1292–1297. doi:10.1104/pp
David Kirsch (427 words) [view diff] exact match in snippet view article find links to article
Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." Nature
GENCODE (2,628 words) [view diff] exact match in snippet view article find links to article
latest additions to the GENCODE project was the CRISPR/Cas9 track on human and model organism assemblies. CRISPR is a genome editing technique that uses sequences
Cyriac Roeding (963 words) [view diff] exact match in snippet view article find links to article
a dozen startups, including LTSE (Long-Term Stock Exchange), Synthego (CRISPR genome editing), Karma Science (acquired by Facebook), Cardspring (acquired
Guangxi Medical University (653 words) [view diff] exact match in snippet view article find links to article
Yongxiang (2013-08-08). "Heritable gene targeting in the mouse and rat using a CRISPR-Cas system". Nature Biotechnology. 31 (8): 681–683. doi:10.1038/nbt.2661
Stygiolobus (192 words) [view diff] exact match in snippet view article find links to article
Rod-Shaped Virus and the Interplay of Crenarchaeal Rudiviruses with the CRISPR Antiviral System". Journal of Bacteriology. 190 (20): 6837–6845. doi:10
Bayside, Wisconsin (1,459 words) [view diff] exact match in snippet view article find links to article
Institute, patent holder re: Method to Bioengineer Designer Platelets using CRISPR/Cas9 and Stem Cell Methodologies "2019 U.S. Gazetteer Files". United States
Cancer research (1,919 words) [view diff] exact match in snippet view article find links to article
2013. Retrieved July 23, 2013. Chinese scientists to pioneer first human CRISPR trial Cerwenka, Adelheid; Lanier, Lewis L. (2016). "Natural killer cell
Marcela Maus (672 words) [view diff] exact match in snippet view article find links to article
barrier, infiltrate a tumour and illicit an immune response. Maus has used CRISPR-Cas9 to develop the CAR-T cells that incorporate a molecule called Bi-specific
Whitehead Institute (1,966 words) [view diff] exact match in snippet view article find links to article
Toxoplasma to model conserved aspects of apicomplexan biology, and recently used CRISPR-based genetic screens to identify parasite genes that contribute to infection
Rhodobacter sphaeroides (2,050 words) [view diff] exact match in snippet view article find links to article
its metabolic fluxes. For facilitating genome editing in this species, a CRISPR/Cas9 genome editing tool was developed and expanded. Moreover, partitioning
Mutation breeding (4,122 words) [view diff] exact match in snippet view article find links to article
use of bacterial restriction endonucleases (RE) - for example Fok1 and CRISPR/Cas9 - to study double-stranded breaks in plant DNA began in the mid-nineties
Breakthrough of the Year (1,125 words) [view diff] exact match in snippet view article find links to article
Higgs boson 2013: Cancer immunotherapy 2014: Rosetta comet mission 2015: CRISPR genome-editing method 2016: First observation of gravitational waves 2017:
Limb–girdle muscular dystrophy (1,488 words) [view diff] exact match in snippet view article find links to article
(for different disorders) have increased interest in researchers, with CRISPR/Cas9 and exon-skipping helping these therapeutic goals along. Limb–girdle
Shah M. Faruque (894 words) [view diff] exact match in snippet view article find links to article
cholera epidemics. His team has also conducted cutting-edge research in CRISPR-Cas systems carried by bacterial viruses such as the JSF series of bacteriophages
Women in chemistry (1,519 words) [view diff] exact match in snippet view article find links to article
applied chemistry. 2020 - Emmanuelle Charpentier and Jennifer Doudna - for CRISPR gene editing 2018 – Frances Arnold – directed evolution to engineer enzymes
Schistosomiasis (6,447 words) [view diff] exact match in snippet view article find links to article
that it was not effective despite provoking some immune response. Using CRISPR gene editing technology, researchers decreased the symptoms due to schistosomiasis
Derrick Rossi (1,569 words) [view diff] exact match in snippet view article find links to article
2015 Rossi was scientific co-founder of Intellia Therapeutics, which uses CRISPR gene editing for developing new drugs for treating genetic diseases. In
Michel Sadelain (2,269 words) [view diff] exact match in snippet view article find links to article
Mithat; Sadelain, Michel (2017–03). "Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection" Nature. 543 (7643): 113–117. doi:10.1038/nature21405
NAS Award in Molecular Biology (1,692 words) [view diff] exact match in snippet view article find links to article
immune systems, groundbreaking work that catalyzed the manipulation of the CRISPR-Cas9 pathway for genome engineering. Dianne K. Newman (2016) For her discovery
Triptolide (889 words) [view diff] exact match in snippet view article find links to article
Wu, E. McWhinnie, J. A. Tallarico, Y.Yang, Y. Feng, DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells. Nat. Chem. Biol
Homology directed repair (1,126 words) [view diff] exact match in snippet view article find links to article
Lowder, Levi; Qi, Yiping (2017-04-24). "Plant genome editing with TALEN and CRISPR". Cell & Bioscience. 7 (1): 21. doi:10.1186/s13578-017-0148-4. ISSN 2045-3701
Md. Tofazzal Islam (3,539 words) [view diff] exact match in snippet view article find links to article
technology. He has also developed blast resistant wheat varieties using CRISPR-Cas9 genome editing and also molecular breeding through introgression of
Leber congenital amaurosis (1,821 words) [view diff] exact match in snippet view article find links to article
Casey Eye Institute of the Oregon Health & Science University injected a CRISPR-modified virus into a patient's eye in an attempt to treat LCA10. In the
Synechococcus elongatus (608 words) [view diff] exact match in snippet view article find links to article
sulfoxide (DMSO) as a cryoprotectant. Ungerer and colleagues, 2018, used CRISPR/Cpf1, to perform a mutational analysis of S. elongatus UTEX 2973 by identifying
NAS Award in Chemical Sciences (1,259 words) [view diff] exact match in snippet view article find links to article
co-inventing the technology for efficient site-specific genome engineering using CRISPR/Cas9 nucleases. Armand Paul Alivisatos (2017) For making fundamental contributions
Recombineering (2,138 words) [view diff] exact match in snippet view article find links to article
Engineering, in the Church lab. With the development of CRISPR technologies, construction of CRISPR interference strains in E. coli requires only one-step
Vienna Biocenter (419 words) [view diff] exact match in snippet view article find links to article
Charpentier and Jennifer Doudna for their groundbreaking discoveries on the CRISPR/Cas9 system. Emmanuelle Charpentier was a principal investigator at the
Mitochondrial replacement therapy (4,463 words) [view diff] exact match in snippet view article find links to article
Against Genetic Disease". Wall Street Journal. Fogleman, Sarah (2016-09-20). "CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and
Timeline of Monsanto (711 words) [view diff] exact match in snippet view article find links to article
With $56 Billion Bid". The New York Times. Retrieved September 14, 2016. "Monsanto Buys Rights to CRISPR". The-scientist.com. Retrieved October 3, 2016.
Non-fungible token (5,939 words) [view diff] exact match in snippet view article find links to article
NFTs for the patent disclosures for two Nobel Prize-winning inventions: CRISPR-Cas9 gene editing and cancer immunotherapy. The university will continue
Kynurenic acid (1,388 words) [view diff] exact match in snippet view article find links to article
Enten JF, Lambert NA, Isom DG (June 2020). "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand
The Hastings Center (1,625 words) [view diff] exact match in snippet view article find links to article
the human impact on nature, governance of emerging technologies such as CRISPR gene editing, and wise and compassionate health care. The Hastings Center
CRSP (108 words) [view diff] exact match in snippet view article find links to article
CRSP can refer to: The stock ticker for CRISPR Therapeutics CRSP customs Durable high performance custom snow sports equipment made in Winter Park, CO
Jian-Kang Zhu (2,363 words) [view diff] exact match in snippet view article find links to article
efficient methods for precise gene editing in plants using TALE nucleases and CRISPR/Cas. They developed the first efficient gene targeting method for the model
Diamondback moth (4,266 words) [view diff] exact match in snippet view article find links to article
requires precise research to identify suitable genetic targets. Using the CRISPR/Cas9 system as a targeted gene to identify the abdominal segment, thus removing
Myostatin (4,949 words) [view diff] exact match in snippet view article find links to article
significantly over-represented in the top racing classes. In 2016, the CRISPR/Cas9 system was used to genetically engineer rabbits and goats with no functional
Messenger RNA (5,207 words) [view diff] exact match in snippet view article find links to article
and respiratory inflammatory diseases. Gene editing therapies such as CRISPR may also benefit from using mRNA to induce cells to make the desired Cas
John J. Zhang (1,506 words) [view diff] exact match in snippet view article find links to article
Natural Society. Retrieved 29 October 2016. Regalado, Antonio. "China's CRISPR babies: Read exclusive excerpts from the unseen original research". MIT
Har Gobind Khorana (2,310 words) [view diff] exact match in snippet view article find links to article
scientists referred to his research while advancing genome editing with the CRISPR/Cas9 system. He extended the above to long DNA polymers using non-aqueous
Institute of Genomics and Integrative Biology (2,173 words) [view diff] exact match in snippet view article find links to article
Researchers at CSIR-IGIB also developed the test called FELUDA based on CRISPR gene editing which is highly efficient and fast to combat the testing capacity
Jung-Min Lee (849 words) [view diff] exact match in snippet view article find links to article
active targeted therapy. [1] Her research has expanded to include the use of CRISPR-Cas9 mediated therapeutic editing of genes involved in disease causing such
List of fictional crocodilians (403 words) [view diff] exact match in snippet view article find links to article
in Africa responsible for the deaths of 300 people. Lizzie Rampage 2018 Brad Peyton A giant American crocodile from the Everglades mutated by CRISPR.
Pain management (8,359 words) [view diff] exact match in snippet view article find links to article
adjuvant. In 2021, researchers described a novel type of pain therapy – a CRISPR-dCas9 epigenome editing method for repressing Nav1.7 gene expression which
Eugene Koonin (1,012 words) [view diff] exact match in snippet view article find links to article
Koonin, Eugene V. (2015-09-28). "An updated evolutionary classification of CRISPR–Cas systems". Nature Reviews Microbiology. Nature Portfolio. 13 (11): 722–736
Randy Read (1,251 words) [view diff] exact match in snippet view article find links to article
J.; Wiedenheft, B (2014). "Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli". Science. 345 (6203):
HacDC (530 words) [view diff] exact match in snippet view article find links to article
Group Gentle Hacker's Literary Salon RepRap 3D printer [1] HacDC Spaceblimp CRISPR-Cas9 bacterial gene editing project. Scanning electron microscope refurbishment
Zhang (surname) (2,685 words) [view diff] exact match in snippet view article
(born 1982), neuroscientist and biomedical engineer in optogenetics and CRISPR technologies Guoqi Zhang speciality in electronics Huaguang Zhang speciality
COVID-19 testing (20,041 words) [view diff] exact match in snippet view article find links to article
chain reaction (RT-PCR) test. Other methods used in molecular tests include CRISPR, isothermal nucleic acid amplification, digital polymerase chain reaction
Streptococcus (3,394 words) [view diff] exact match in snippet view article find links to article
Strep B Foundation The UK [[Group B Strep Support charity] Nature-Inspired CRISPR Enzyme Discoveries Vastly Expand Genome Editing . On: SciTechDaily. June
Microscope (3,549 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
Forward genetics (1,430 words) [view diff] exact match in snippet view article find links to article
Grati M, Ohtsuka M, Schilit SL, Quadros RM, Liu XZ (September 2016). "CRISPR: a versatile tool for both forward and reverse genetics research". Human
International Science and Engineering Fair (2,297 words) [view diff] exact match in snippet view article find links to article
SUNY Chancellor Dianne Newman (1987): Microbiologist Feng Zhang (2000): CRISPR researcher Alexandria Ocasio-Cortez (2007): United States Congresswoman
Joe Egender (816 words) [view diff] case mismatch in snippet view article find links to article
Megan (October 18, 2019). "A Netflix Series Explores the Brave New World of Crispr - From malaria-ridden villages in Burkina Faso to fertility clinics in Ukraine
CD9 (3,124 words) [view diff] exact match in snippet view article find links to article
(November 2018). "Ablation of the CD9 receptor in human lung cancer cells using CRISPR/Cas alters migration to chemoattractants including IL-16". Cytokine. 111:
Gregory Hannon (1,245 words) [view diff] exact match in snippet view article find links to article
Therapeutics Institute, aims to act as a hub for genetic screens, cancer models, CRISPR tool design, and computational approaches to big data to understand genetic
Cellectis (776 words) [view diff] exact match in snippet view article find links to article
company employed nearly 300 people in early 2014. With the advent of the CRISPR (clustered regularly interspaced short palindromic repeat) genome editing
Max Planck Institute for Infection Biology (1,008 words) [view diff] exact match in snippet view article find links to article
www.nobelprize.org. Retrieved 7 October 2020. "Emmanuelle Charpentier, CRISPR-Cas9, Max Planck Institute for Infection Biology". Max Planck Unit for the
Cystic fibrosis (15,812 words) [view diff] exact match in snippet view article find links to article
rendered unusable. There has been a functional repair in culture of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Phage
Ark Invest (1,258 words) [view diff] exact match in snippet view article find links to article
technology. These technologies include artificial intelligence, DNA sequencing, CRISPR gene editing, robotics, electric vehicles, energy storage, fintech, 3D printing
Scientific American (3,853 words) [view diff] exact match in snippet view article find links to article
Human Species 2015: Year of the Dwarf Planets and New Views of Mars The CRISPR Revolution Gains Momentum Massive Data Breach Highlights Widespread Cybersecurity
Communication (7,070 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
Target Malaria (1,125 words) [view diff] exact match in snippet view article find links to article
Should We? The New York Times Magazine Ryan, Jackson (6 February 2019). "The CRISPR machines that can wipe out entire species". CNET. Retrieved 20 February
Machine (6,472 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
Science Olympiad (3,311 words) [view diff] exact match in snippet view article find links to article
resources to construct a physical model of a protein that is being used with CRISPR Cas9 to edit plant and animal genomes. This year's event will focus on modifications
ATAC-seq (1,688 words) [view diff] exact match in snippet view article find links to article
KM, Smith SB, Meadows SK, Roberts BS, et al. (October 2015). "CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins". Genome Research. 25 (10):
PerkinElmer (2,903 words) [view diff] case mismatch in snippet view article find links to article
https://www.biospace.com/article/perkinelmer-expands-horizons-with-383m-crispr-tech-acquisition-/?s=79 "PerkinElmer Completes Acquisition of Oxford Immunotec
Chimeric antigen receptor T cell (6,465 words) [view diff] exact match in snippet view article find links to article
times due to a partial deletion of the U3 region. The new gene editing tool CRISPR/Cas9 has recently been used instead of retroviral vectors to integrate the
Technology (8,127 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
Diatom (11,019 words) [view diff] exact match in snippet view article find links to article
possibility to remove it. Furthermore, these systems now allow the use of the CRISPR-Cas genome edition tool, leading to a fast production of functional knock-out
Development, Growth & Differentiation (291 words) [view diff] exact match in snippet view article find links to article
122-129 2014 Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes. 3237 2014 Ken-ichi Nishijima and Shinji Iijima
Vehicle (6,206 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
Viroid (3,029 words) [view diff] exact match in snippet view article find links to article
Report Viroids". Hadidi A (January 2019). "Next-Generation Sequencing and CRISPR/Cas13 Editing in Viroid Research and Molecular Diagnostics". Viruses. 11
Emerging technologies (4,824 words) [view diff] exact match in snippet view article find links to article
Antony, Justin S; Handgretinger, Rupert; Mezger, Markus (20 May 2020). "CRISPR/Cas9 technology: towards a new generation of improved CAR-T cells for anticancer
Rampage (soundtrack) (282 words) [view diff] case mismatch in snippet view article
"Paavos" 1:22 4. "Calm" 3:10 5. "Wydens" 2:14 6. "Kate" 2:15 7. "Lab" 1:09 8. "Crispr" 4:46 9. "Wyoming" 1:21 10. "Antennae" 3:00 11. "C17" 5:50 12. "Cornfield"
Harvey Prize (3,023 words) [view diff] exact match in snippet view article find links to article
Jennifer Doudna, U.S. and Feng Zhang, U.S. – "for leading the development of CRISPR-Cas9 technology, a breakthrough in genetic modification." 2018 – Christos
List of investigational analgesics (816 words) [view diff] exact match in snippet view article find links to article
[56] KCP-506 – nicotinic acetylcholine receptor antagonist [57] LATER – CRISPR-dCas9 gene-editing [58] PAX-01 – undefined mechanism of action [59] List
Kang Zhang (2,561 words) [view diff] exact match in snippet view article find links to article
Callaway EM, Zhang K, Belmonte JC (December 2016). "In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration". Nature. 540 (7631):
Transcriptome instability (360 words) [view diff] exact match in snippet view article find links to article
splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing". Blood Cells, Molecules and Diseases. 69: 10–22. doi:10
Late endosomal/lysosomal adaptor, mapk and mtor activator 1 (538 words) [view diff] exact match in snippet view article find links to article
(April 2017). "Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed
SPATA16 (461 words) [view diff] exact match in snippet view article find links to article
Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models". International Journal of Molecular Sciences
5-Hydroxymethylcytosine (1,744 words) [view diff] exact match in snippet view article find links to article
(16 June 2015). "Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9". mBio. 6 (3): e00648. doi:10.1128/mBio.00648-15. PMC 4471564. PMID 26081634
Scott W. Lowe (983 words) [view diff] exact match in snippet view article find links to article
suppressor genes. He is also known for using genome-editing tools such as CRISPR to create valuable mouse models of different cancers. He moved to Memorial
John Maraganore (928 words) [view diff] exact match in snippet view article find links to article
2021-09-15. Martz, Lauren; Editor, Senior. "Alnylam's strategy to head off CRISPR threat". BioCentury. Retrieved 2021-09-09.CS1 maint: extra text: authors
January–March 2021 in science (13,323 words) [view diff] exact match in snippet view article find links to article
repaired by improving the energy levels in mitochondria. Scientists describe a CRISPR-Cas9 genome editing approach which could be used to treat wet age-related
Tang Prize (1,090 words) [view diff] exact match in snippet view article find links to article
Biopharmaceutical Science Emmanuelle Charpentier  France "for the development of CRISPR/Cas9 as a breakthrough genome editing platform that promises to revolutionize
Spinocerebellar ataxia type 1 (10,037 words) [view diff] exact match in snippet view article find links to article
both CRISPR and Zinc fingers nucleases that rely on double strand breaks trigger contractions and expansions with nearly equal frequency, while CRISPR using
High-throughput screening (4,025 words) [view diff] exact match in snippet view article find links to article
full functional genomics capabilities (genome wide siRNA, shRNA, cDNA and CRISPR) which are complementary to small molecule efforts: Functional genomics
DNA digital data storage (2,888 words) [view diff] exact match in snippet view article find links to article
storage and retrieval information stored in the cell's genetic material. CRISPR gene editing can also be used to insert artificial DNA sequences into the
List of single cell omics methods (4,717 words) [view diff] exact match in snippet view article find links to article
David E, et al. (December 2016). "Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq". Cell. 167 (7): 1883–1896.e15.
Oct-4 (3,917 words) [view diff] exact match in snippet view article find links to article
transcriptional inhibition of cyclin-dependent kinase inhibitors such as p21. CRISPR-Cas9 knockout of the gene in human embryonic stem cells demonstrated that
Croonian Medal (8,713 words) [view diff] exact match in snippet view article find links to article
dystrophin related proteins 2018 Jennifer Doudna, Re-writing the Code of Life: CRISPR Systems and Applications of Gene Editing 2017 Jonathan Felix Ashmore, for
List of Pomona College people (8,153 words) [view diff] exact match in snippet view article find links to article
original on February 15, 2021. Retrieved August 4, 2020. Rogers, Adam. "A CRISPR Cut". Pomona College Magazine (Spring 2015). Pomona College. Archived from
KDM1A (1,709 words) [view diff] exact match in snippet view article find links to article
Kwan EE, Senzer BD, Doench JG, Bauer DE, Pinello L, Liau BB (May 2019). "CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML". Nature
Patricia Piccinini (1,620 words) [view diff] exact match in snippet view article find links to article
Place Is My Place / Rosi Braidotti in conversation with Patricia Piccinini. CRISPR and Emergent Forms of Life / Eben Kirksey. ISBN 9788778751317 Mcdonald,
Plastic (9,934 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
2010s in science and technology (4,867 words) [view diff] exact match in snippet view article find links to article
York Times. Retrieved 21 February 2019. Belluz, Julia (4 March 2019). "CRISPR babies: the Chinese government may have known more than it let on". Vox
Trans-regulatory element (1,295 words) [view diff] exact match in snippet view article find links to article
PMID 26104458. McGinn J, Marraffini LA (January 2019). "Molecular mechanisms of CRISPR-Cas spacer acquisition". Nature Reviews. Microbiology. 17 (1): 7–12. doi:10
Integrated circuit (8,343 words) [view diff] exact match in snippet view article find links to article
Biotechnology Birth control Blood transfusion Dentistry Genetic engineering CRISPR gene editing Genetic testing PCR Hospital Medical imaging Medication Anesthesia
Gene (11,219 words) [view diff] exact match in snippet view article find links to article
Agarwala V, Scott DA, Zhang F (November 2013). "Genome engineering using the CRISPR-Cas9 system". Nature Protocols. 8 (11): 2281–2308. doi:10.1038/nprot.2013
KBM-7 cells (684 words) [view diff] exact match in snippet view article find links to article
Essletzbichler, Patrick; et al. (December 2014). "Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line". Genome Research. 24 (12):
Single cell sequencing (7,747 words) [view diff] exact match in snippet view article find links to article
primer sets for other species would take considerable effort. Recently, a CRISPR-based method named scDASH (single-cell depletion of abundant sequences by
UCK2 (2,384 words) [view diff] exact match in snippet view article find links to article
Glenn JS, Carette JE, Khosla C, Bassik MC (May 2016). "Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification". Nature Chemical
Mosquito (12,571 words) [view diff] exact match in snippet view article find links to article
Environment, Retrieved 11 June 2014 Kyros Kyrou; et al. (Sep 24, 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression
PCSK9 (7,160 words) [view diff] exact match in snippet view article find links to article
acts by means of RNA interference. In 2021, scientists demonstrated that CRISPR gene editing can decrease blood levels of LDL cholesterol in vivo in Macaca
Revival of the woolly mammoth (1,565 words) [view diff] exact match in snippet view article find links to article
potential to become embryonic stem cells. By March 2015 and using the new CRISPR DNA editing technique, Church's team had some woolly mammoth genes edited
Daniel Kevles (1,484 words) [view diff] exact match in snippet view article find links to article
Yale University History Department. Interview with Daniel J. Kevles about CRISPR technology, 5 May 2016, TED.com. Lecture by Daniel J Kevles, "Patenting
Hypotrichosis with juvenile macular dystrophy (962 words) [view diff] exact match in snippet view article find links to article
disorder. A number of studies are looking at gene therapy, exon skipping and CRISPR interference to offer hope for the future. Accurate determination through
Multiple loci VNTR analysis (692 words) [view diff] exact match in snippet view article find links to article
"On-line resources for bacterial micro-evolution studies using MLVA or CRISPR typing". Biochimie. 90 (4): 660–8. doi:10.1016/j.biochi.2007.07.014. PMID 17822824
Anthony L. Komaroff (980 words) [view diff] exact match in snippet view article find links to article
PMID 28006047. S2CID 5078210. Komaroff, AL (2017). "Gene editing using CRISPR: why the excitement?". JAMA. 318 (8): 699–700. doi:10.1001/jama.2017.10159
Capitella teleta (4,580 words) [view diff] exact match in snippet view article find links to article
includes use of gene perturbation techniques such as Morpholino knockdown and CRISPR-Cas9 mutagenesis, and methods for living imaging such as mRNA injection
Public awareness of science (2,966 words) [view diff] exact match in snippet view article find links to article
engagement", especially with emerging science and technology issues, like CRISPR gene editing, that have the potential to become "wicked problems." These
Nathaniel C. Comfort (633 words) [view diff] exact match in snippet view article find links to article
2015). "Slipping Into Eugenics? Nathaniel Comfort on the History Behind CRISPR". Biopolitical Times. Comfort, Nathaniel (July 16, 2015). "Can We Cure Genetic
Boron (10,841 words) [view diff] exact match in snippet view article find links to article
modality PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. The dual-modality small molecule
Sandhoff disease (3,008 words) [view diff] exact match in snippet view article find links to article
showing proof of principle for gene therapy in a human model system using CRISPR and virus gene correction gives the chance for clinical trials to cure the
The Bragg UNSW Press Prize for Science Writing (820 words) [view diff] exact match in snippet view article find links to article
species and shadow places" (Griffith Review) and Jackson Ryan for "How CRISPR could save six billion chickens from the meat grinder" (CNET). The 2020
Virotherapy (3,468 words) [view diff] exact match in snippet view article find links to article
additional to viral gene editing, other genome editing technologies such as CRISPR gene editing have been shown to be more precise with more control over the
Nannochloropsis (2,925 words) [view diff] exact match in snippet view article find links to article
lipid percentages in Nannochloropsis gaditana through applications of the CRISPR-Cas9 reverse-genetics pipeline and nitrogen starving—improving partitioning
Nannochloropsis (2,925 words) [view diff] exact match in snippet view article find links to article
lipid percentages in Nannochloropsis gaditana through applications of the CRISPR-Cas9 reverse-genetics pipeline and nitrogen starving—improving partitioning
Domestication syndrome (1,884 words) [view diff] exact match in snippet view article find links to article
Kunling; Wang, Yanpeng; Zhang, Rui; Zhang, Huawei; Gao, Caixia (2019-04-29). "CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture". Annual
Alternative splicing (7,924 words) [view diff] exact match in snippet view article find links to article
splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing". Blood Cells, Molecules & Diseases. 69: 10–22. doi:10
PAC-1 (1,828 words) [view diff] exact match in snippet view article find links to article
to PAC-1-type compounds. Recent experiments using cancer cell lines with CRISPR deletion of CASP3 are also consistent with this result. The activation of
DARPA (9,756 words) [view diff] exact match in snippet view article find links to article
consisting of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based assays paired with reconfigurable point-of-need and massively multi-plexed
Asad Ullah Khan (2,245 words) [view diff] exact match in snippet view article find links to article
06.015. PMID 28673854. Zuberi, Azna; Misba, Lama; Khan, Asad U (2017). "CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. Coli: An
Essential gene (8,351 words) [view diff] exact match in snippet view article find links to article
can lead to erroneous annotations (here: false negatives). Comparison of CRISPR/cas9 and RNAi screens. Screens to identify essential genes in the human
Association of Biomolecular Resource Facilities (1,817 words) [view diff] exact match in snippet view article find links to article
2016 Emmanuelle Charpentier and Jennifer Doudna for the development of CRISPR/Cas9 Genome Editing Technologies. 2015 John G. White and William Bradshaw
Amyotrophic lateral sclerosis (17,003 words) [view diff] exact match in snippet view article find links to article
which viruses are used to deliver mutant genes to an animal model, and CRISPR/Cas9, which can be used to give an animal model multiple mutated genes.
EteRNA (1,214 words) [view diff] exact match in snippet view article find links to article
OpenTB, Eterna launched OpenCRISPR in August 2017, which challenges players to design single guide RNAs (sgRNAs) used in CRISPR gene editing. The goal of
Glutamate carboxypeptidase II (3,948 words) [view diff] exact match in snippet view article find links to article
modality PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. PSMA can also be used experimentally
Mosquito control (5,080 words) [view diff] exact match in snippet view article find links to article
Galizi, Roberto; Hammond, Andrew M.; Kyrou, Kyros (24 September 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression
Xiaoliang Sunney Xie (1,956 words) [view diff] exact match in snippet view article find links to article
Wensheng; Xie, X. Sunney (2017). "Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging". Cell Res. 27 (2): 298–301. doi:10.1038/cr.2017
Mitochondrial calcium uniporter (677 words) [view diff] exact match in snippet view article find links to article
the mitochondrial calcium uniporter complex resumes. Research using a CRISPR/Cas9 technique has found that MICU1 and MICU2 play other roles as well.
Catherine Abbott (565 words) [view diff] exact match in snippet view article find links to article
important gene mutations they have discovered so far. She is interested in CRISPR/Cas Tools for gene editing. Abbott is a campaigns for diversity within the
Palmitoylethanolamide (5,569 words) [view diff] exact match in snippet view article find links to article
PMID 30929760. Mikaeili H, Yeung C, Habib AM, Wood JN, Okorokov AL, Cox JJ (2019). "CRISPR interference at the FAAH-OUT genomic region reduces FAAH expression". bioRxiv 10
Seaweed farming (5,768 words) [view diff] exact match in snippet view article find links to article
Synthetic Genomics report breakthrough in algae biofuel research". ExxonMobil. "CRISPR-edited algae with high biofuel yield created by ExxonMobil, Craig Venter's
Human Frontier Science Program (1,740 words) [view diff] exact match in snippet view article find links to article
(University of California, Berkeley, USA), "for their seminal work on the CRISPR-Cas9 system". 2017 David Julius (University of California, San Francisco
Biology (26,019 words) [view diff] exact match in snippet view article find links to article
libraries, DNA microarrays, expression vectors, synthetic genomics, and CRISPR gene editing. Many of these tools have wide applications such as creating
Paleogenomics (2,594 words) [view diff] exact match in snippet view article find links to article
as the mammoth. This project, which appears to be possible thanks to the CRISPR/Cas9 technology, is, however, strongly connected to many ethical issues
Woolly mammoth (16,376 words) [view diff] exact match in snippet view article find links to article
the genes in elephant cells with mammoth genes. By 2015 and using the new CRISPR DNA editing technique, one team had some woolly mammoth genes edited into
Macular degeneration (9,453 words) [view diff] exact match in snippet view article find links to article
studied. A number of trials have occurred in humans with encouraging results. CRISPR-Cas9 genome editing may be used to treat wet age-related macular degeneration
Preclinical imaging (6,073 words) [view diff] exact match in snippet view article find links to article
modality PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. The combining of these imaging
Catherina Becker (1,037 words) [view diff] exact match in snippet view article find links to article
; Lyons, D.A.; Becker, T (2020). "Phenotypic screening using synthetic CRISPR gRNAs reveals pro-regenerative genes in spinal cord injury". bioRxiv 10
COVID-19 pandemic in Karnataka (5,462 words) [view diff] exact match in snippet view article find links to article
Indian scientists at Institute of Genomics and Integrative Biology, using CRISPR gene editing tool developed a low cost paper-strip test for COVID-19, which
CCR5 (7,651 words) [view diff] exact match in snippet view article find links to article
1111/j.1468-1293.2007.00455.x. PMID 17461848. S2CID 24900064. "China's CRISPR twins might have had their brains inadvertently enhanced". Technology Review
Marine protists (10,408 words) [view diff] exact match in snippet view article find links to article
Sharma, Amit Kumar; Sparstad, Torfinn; Bones, Atle M.; Winge, Per (2016). "A CRISPR/Cas9 system adapted for gene editing in marine algae". Scientific Reports
Tony Oursler (4,065 words) [view diff] exact match in snippet view article find links to article
' according to Oursler. He suggests connections between the recent DNA CRISPR-Cas encoding of Muybridge’s Horse in Motion, the birth of the film industry
University of Texas Southwestern Medical Center (4,548 words) [view diff] exact match in snippet view article find links to article
for damage suffered following a heart attack. Olson's lab has also used CRISPR/Cas9 methods to cure Duchenne muscular dystrophy in mice as a proof of principle
Amina Zoubeidi (755 words) [view diff] exact match in snippet view article find links to article
BRN2 was essential for NEPC to develop. She firstly used genome editing CRISPR technology to freeze the gene producing the protein driving the emergence
Cerebral organoid (5,415 words) [view diff] case mismatch in snippet view article find links to article
genetic modification will remain present in cells resulting from replication. Crispr/Cas 9 is a method by which this long-lasting genetic modification can be
David Goodsell (1,075 words) [view diff] exact match in snippet view article find links to article
Example of individual protein: Cascade surveillance complex of the Type I CRISPR bacterial immune system from Escherichia coli (2015). The Cascade protein
Francoise Baylis (5,058 words) [view diff] exact match in snippet view article find links to article
changing things for the better." Baylis, F. (2019). Altered Inheritance: CRISPR and the Ethics of Human Genome Editing. Harvard University Press. ISBN 9780674976719
Amyotrophic lateral sclerosis research (2,123 words) [view diff] exact match in snippet view article find links to article
case, motor cells can be grown, and the gene expression is controlled. CRISPR/Cas9 technique can be used to knock-out/in genes that are related to ALS
Bhabha Atomic Research Centre (7,482 words) [view diff] exact match in snippet view article find links to article
regulation of alternate splicing in plants and mammalian cells. Development of CRISPR-Cas mediated genome editing technologies in both basic and applied research
Shijiazhuang (6,466 words) [view diff] exact match in snippet view article find links to article
Chinese-American biochemist. Known for his role in the development of CRISPR technologies. Sun Yingsha, table tennis player. Zhao Tuo, Qin dynasty Chinese