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searching for Immune checkpoint 159 found (210 total)

alternate case: immune checkpoint

Mucosal melanoma (435 words) [view diff] exact match in snippet view article find links to article

capacity to improve survival in clinical and observational studies, immune checkpoint inhibitors (e.g., pembrolizumab) have been tested in mucosal melanomas
Camrelizumab (119 words) [view diff] exact match in snippet view article find links to article
Camrelizumab (SHR-1210) (INN) is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma
Timeline of immunology (2,182 words) [view diff] exact match in snippet view article find links to article
P. Allison is the first to describe the function of the critical immune checkpoint CTLA-4 1995 – Regulatory T cells (Shimon Sakaguchi) 1995 – First Dendritic
Checkpoint inhibitor induced colitis (1,705 words) [view diff] exact match in snippet view article find links to article
or vomiting warrant evaluation with upper endoscopy. Treatment of immune checkpoint inhibitor colitis is based on severity, as defined by the grade of
Abscopal effect (1,126 words) [view diff] exact match in snippet view article find links to article
were extremely rare throughout the 20th century, the clinical use of immune checkpoint blocking antibodies such as ipilimumab or pembrolizumab has greatly
Compugen Ltd. (1,976 words) [view diff] exact match in snippet view article find links to article
as an agriscience division in 1999. PVRIG is a novel B7/CD28-like immune checkpoint target candidate. In June 2016, Compugen announced the selection of
Plinabulin (334 words) [view diff] exact match in snippet view article find links to article
chemotherapy-induced neutropenia and for anti-cancer effects in combination with immune checkpoint inhibitors and in KRAS mutated tumors. Plinabulin blocks the polymerization
Arlene Sharpe (252 words) [view diff] exact match in snippet view article find links to article
collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the
Graduate School of Medicine and Faculty of Medicine, Kyoto University (529 words) [view diff] exact match in snippet view article find links to article
in Physiology or Medicine in 2018 for his discovery and theory of immune checkpoint inhibitors. In 1899, College of Medicine (医科大学) and its hospital (now
DNA mismatch repair (4,179 words) [view diff] exact match in snippet view article find links to article
mismatch repair mutations were initially observed to associate with immune checkpoint blockade efficacy in a study examining responders to anti-PD1. The
Immunologic checkpoint (385 words) [view diff] exact match in snippet view article find links to article
An immune checkpoint regulator is a modulator of the immune system, that allows initiation of a productive immune response and prevents the onset of autoimmunity
TNFAIP8L2 (421 words) [view diff] exact match in snippet view article find links to article
preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism. TNFAIP8L2 is a member of
Sialic acid binding ig-like lectin 15 (271 words) [view diff] exact match in snippet view article find links to article
demonstrated that antibody blockade of the Siglec-15/sialic acid glycol-immune checkpoint axis can act as a potential treatment for breast cancer bone metastasis
Tak Wah Mak (1,659 words) [view diff] exact match in snippet view article find links to article
published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint
Myocarditis-myositis-myasthenia gravis overlap syndrome (271 words) [view diff] exact match in snippet view article find links to article
immune-related adverse event primarily associated with the use of immune checkpoint inhibitors (ICIs). These ICIs, which have been incorporated into the
Nivolumab (4,777 words) [view diff] exact match in snippet view article find links to article
Thus, the T cells can kill the cancer cells. This is an example of immune checkpoint blockade. PD-1 is a protein on the surface of activated T cells. If
Nanobiotix (1,779 words) [view diff] no match in snippet view article find links to article
Nanobiotix is a biotechnology company that uses nanomedicine to develop new radiotherapy techniques for cancer patients. The company is headquartered in
Gestational choriocarcinoma (2,873 words) [view diff] exact match in snippet view article find links to article
reduce the risk of resistance are currently being researched, such as immune checkpoint inhibitors. Studies of gestational choriocarcinoma demonstrate an
Immunotherapy (5,399 words) [view diff] case mismatch in snippet view article find links to article
(2015). "Immune Checkpoint Inhibitors". Progress in Tumor Research. 42: 55–66. doi:10.1159/000437178. ISBN 978-3-318-05589-4. PMID 26382943. "Immune Checkpoint
Flotetuzumab (195 words) [view diff] exact match in snippet view article find links to article
therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors". Curr. Opin. Hematol. 25 (2): 136–145. doi:10.1097/MOH
CD40 (protein) (2,845 words) [view diff] exact match in snippet view article
in preclinical glioma models, and in fact affect the efficacy of immune checkpoint blockade. This is likely due to the high mutational burden most of
Lung cancer (9,708 words) [view diff] exact match in snippet view article find links to article
therapy are combined with newer targeted molecular therapies and immune checkpoint inhibitors. All lung cancer treatment regimens are combined with lifestyle
Tissue-resident memory T cell (3,011 words) [view diff] exact match in snippet view article find links to article
upregulated immune checkpoint receptors. This suggests, that most of the tumor TRM show an exhausted phenotype which may be saved by immune checkpoint inhibitor
NT5E (2,141 words) [view diff] exact match in snippet view article find links to article
et al. (January 2020). "2B-mediated feedforward circuit enforces an immune checkpoint". Nature Communications. 11 (1): 515. doi:10.1038/s41467-019-14060-x
Molecular oncology (1,081 words) [view diff] exact match in snippet view article find links to article
cellular and molecular level. Some regulatory proteins, specifically immune checkpoint inhibitors, have been found to reduce the ability of T cells to multiply
Combinatorial ablation and immunotherapy (1,148 words) [view diff] case mismatch in snippet view article find links to article
Oklu, Rahmi; Sheth, Rahul A. (2015). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response
Fibrolamellar hepatocellular carcinoma (2,189 words) [view diff] exact match in snippet view article find links to article
which include extended information on patient outcomes, efficacy of immune checkpoint inhibitors, efficacy of specific drugs and understanding the basis
GPER (4,250 words) [view diff] exact match in snippet view article find links to article
GPER agonist, LNS8801, as monotherapy and in combination with the immune checkpoint inhibitor, pembrolizumab, for the treatment of multiple solid tumor
Paraneoplastic syndrome (2,358 words) [view diff] exact match in snippet view article find links to article
[citation needed] Paraneoplastic neurological syndromes may be related immune checkpoint inhibitors (ICIs), one of the underlying causes in inflammatory central
PD-L1 (2,846 words) [view diff] exact match in snippet view article find links to article
et al. (December 2019). "EBV microRNA-BHRF1-2-5p targets the 3'UTR of immune checkpoint ligands PD-L1 and PD-L2". Blood. 134 (25): 2261–2270. doi:10.1182/blood
James P. Allison (2,156 words) [view diff] exact match in snippet view article find links to article
that target T-cell inhibitory pathways, which have been labeled as "immune checkpoint therapies". This work ultimately led to the clinical development of
Tyrosine sulfation (747 words) [view diff] exact match in snippet view article find links to article
binding to P-selectin but also enables its pH-selective binding to the immune checkpoint protein VISTA. In 2006, an article was published in the Journal of
Cancer vaccine (3,112 words) [view diff] exact match in snippet view article find links to article
Since tumors often evolve mechanisms to suppress the immune system, immune checkpoint blockade has recently received a lot of attention as a potential treatment
Sarcoma (3,903 words) [view diff] exact match in snippet view article find links to article
still under investigation is the use of cancer immunotherapy (e.g., immune checkpoint inhibitors like anti-PD1, anti-PDL1, and anti-CTLA4 agents) to treat
Cryoimmunotherapy (1,720 words) [view diff] case mismatch in snippet view article find links to article
in the 1970s. Mehta Amol (2016). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response"
Jiangsu Hengrui (475 words) [view diff] exact match in snippet view article find links to article
has run clinical trials on anti-cancer drugs such as: An anti-PD-1 immune checkpoint inhibitor camrelizumab for hepatocellular carcinoma; A nonsteroidal
Adagrasib (806 words) [view diff] exact match in snippet view article find links to article
disease has progressed on or after platinum-based chemotherapy and an immune checkpoint inhibitor, given either concurrently or sequentially. The FDA granted
Antibody Solutions (956 words) [view diff] case mismatch in snippet view article find links to article
of Agonist and Antagonist Human Monoclonal Antibodies Against an Immune Checkpoint Target from the H2L2 Mouse Generation and Selection of Human Monoclonal
Melanoma (15,963 words) [view diff] exact match in snippet view article find links to article
countries, but today (2024) the most common adjuvant treatment is immune checkpoint inhibitor treatment for up to a year post-surgery. In the early 2000's
Sanford Burnham Prebys Medical Discovery Institute (2,507 words) [view diff] case mismatch in snippet view article find links to article
Clinical Evidence Supporting Therapeutic Potential of Activating the Immune Checkpoint Receptor BTLA in SLE. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts
CD160 (993 words) [view diff] exact match in snippet view article find links to article
molecules. CD160 is a ligand for HVEM, and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti- PD-1 antibodies
MARCO (2,232 words) [view diff] exact match in snippet view article find links to article
pathways, including immunosuppressive TAMs, T-cell infiltration, and immune checkpoint molecules. Higher infiltration of tumor tissues by macrophages was
Cancer immunology (3,791 words) [view diff] exact match in snippet view article find links to article
cells. monoclonal anti-CTLA4 and anti-PD-1 antibodies are called immune checkpoint inhibitors: CTLA-4 is a receptor upregulated on the membrane of activated
Tumor-infiltrating lymphocytes (2,754 words) [view diff] exact match in snippet view article find links to article
in Lynch syndrome. Also, TILs are associated with most effective immune checkpoint inhibitor therapy in GI cancers. They are an important prognostic
Avelumab (1,471 words) [view diff] exact match in snippet view article find links to article
target for immunotherapy. Therefore, avelumab belongs to the group of immune checkpoint blockade cancer therapies. As of May 2015, according to Merck KGaA
List of human clusters of differentiation (467 words) [view diff] exact match in snippet view article find links to article
T-cells. CD275 ICOSLG or ICOS ligand. CD276 CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of
G1 Therapeutics (2,065 words) [view diff] exact match in snippet view article find links to article
inhibitor, enhances the efficacy of combination chemotherapy and immune checkpoint inhibitor treatment in preclinical models, American Association for
Kidney cancer (4,786 words) [view diff] exact match in snippet view article find links to article
treatments are often followed by everolimus, axitinib, and sorafenib. Immune checkpoint inhibitors are also in trials for kidney cancer, and some have gained
Thymoglobulin (833 words) [view diff] exact match in snippet view article find links to article
vitro, including CD25, GITR, and CTLA-4 (aka CD152, functions as immune checkpoint, downregulates immune response). Recent research has suggested that
Monalizumab (142 words) [view diff] exact match in snippet view article find links to article
Burg SH, Vivier E (October 2019). "Monalizumab: inhibiting the novel immune checkpoint NKG2A". Journal for Immunotherapy of Cancer. 7 (1): 263. doi:10
Head and neck cancer (8,600 words) [view diff] exact match in snippet view article find links to article
activates the immune system to fight cancer. One type of immunotherapy, immune checkpoint blockade, binds to and blocks inhibitory signals on immune cells to
CD83 (2,266 words) [view diff] case mismatch in snippet view article find links to article
Lechmann, Matthias (17 April 2020). "The CD83 Molecule – An Important Immune Checkpoint". Frontiers in Immunology. 11: 721. doi:10.3389/fimmu.2020.00721.
Adoptive cell transfer (4,028 words) [view diff] exact match in snippet view article find links to article
remove inhibitory pathways that block T-cell responses, known as immune checkpoint therapy. As of 2015 the technique had expanded to treat cervical cancer
TNFAIP8 (474 words) [view diff] exact match in snippet view article find links to article
et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99:
Sotorasib (1,773 words) [view diff] exact match in snippet view article find links to article
non-small cell lung cancer with disease progression after receiving an immune checkpoint inhibitor and/or platinum-based chemotherapy. The major outcomes measured
CD200 (1,801 words) [view diff] exact match in snippet view article find links to article
chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200". Journal for Immunotherapy of Cancer. 7 (1): 227. doi:10
PKM2 (4,865 words) [view diff] case mismatch in snippet view article find links to article
(2017-10-13). "Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors". Frontiers in Immunology. 8: 1300
Transitional cell carcinoma (1,988 words) [view diff] exact match in snippet view article find links to article
Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731–e741. doi:10
Vedolizumab (2,341 words) [view diff] case mismatch in snippet view article find links to article
"Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical
Cell ablation (617 words) [view diff] exact match in snippet view article find links to article
review of treatment modalities and the evidence for combination with immune checkpoint inhibitors". Translational Lung Cancer Research. 10 (6): 2842–2857
APC Activator (525 words) [view diff] exact match in snippet view article find links to article
clinical trials in combination with chemotherapy (paclitaxel), or immune checkpoint inhibitors, including the PD-1 monoclonal antibody pembrolizumab,
Autoimmune hypophysitis (1,635 words) [view diff] exact match in snippet view article find links to article
this may be an underestimate, especially due to the recent use of immune checkpoint inhibitors for cancer treatments, which have endocrine side effects
Autoimmune hypophysitis (1,635 words) [view diff] exact match in snippet view article find links to article
this may be an underestimate, especially due to the recent use of immune checkpoint inhibitors for cancer treatments, which have endocrine side effects
The Breakthrough: Immunotherapy and the Race to Cure Cancer (606 words) [view diff] exact match in snippet view article find links to article
believers in the form of regulatory approval of CTLA-4, PD-1, and PD-L1 immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies. The book
Dong Chen (451 words) [view diff] exact match in snippet view article find links to article
Liu, Dongfang; Dong, Chen (August 2017). "Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function". Cell
Zabadinostat (1,094 words) [view diff] exact match in snippet view article find links to article
and enhancing anti-tumour activity, especially when combined with immune checkpoint inhibitors (ICIs), such as anti-PD-1 and anti-CTLA4. In addition,
Padmanee Sharma (476 words) [view diff] exact match in snippet view article find links to article
2019. Sharma, Padmanee; Allison, James P. (2015). "The future of immune checkpoint therapy". Science. 348 (6230): 56–61. doi:10.1126/science.aaa8172
SillaJen (764 words) [view diff] exact match in snippet view article find links to article
Pharmaceuticals to conduct a combination study with Pexa-Vec and Regeneron's immune checkpoint inhibitor cemiplimab for renal cell carcinoma. In July 2017, SillaJen
Sintilimab (382 words) [view diff] exact match in snippet view article find links to article
March 2019. Ansell SM (January 2019). "Sintilimab: another effective immune checkpoint inhibitor in classical Hodgkin lymphoma". The Lancet. Haematology
Antihistamine (3,138 words) [view diff] exact match in snippet view article find links to article
cancer therapies has suggested that when consumed in conjunction with immune checkpoint inhibitors some may influence the response of subjects to that particular
Asunercept (778 words) [view diff] exact match in snippet view article find links to article
BJ (2018). "Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism". Cancer Immunol Immunother. 68 (5): 835–847. Bibcode:2017NatCo
Warren Alpert Foundation Prize (377 words) [view diff] exact match in snippet view article find links to article
collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the
Dostarlimab (3,089 words) [view diff] case mismatch in snippet view article find links to article
ClinicalTrials.gov Green AK, Feinberg J, Makker V (March 2020). "A Review of Immune Checkpoint Blockade Therapy in Endometrial Cancer". American Society of Clinical
T cell (9,026 words) [view diff] exact match in snippet view article find links to article
by T cells. Many experiments and clinical trials have focused on immune checkpoint blockers in cancer therapy, with some of these approved as valid therapies
American Association for Cancer Research (1,251 words) [view diff] exact match in snippet view article find links to article
on targeted therapy, and cancer immunotherapy research including immune checkpoint blockade and Chimeric Antigen Receptor (CAR) T-cell therapy. The AACR
TNFRSF18 (2,107 words) [view diff] exact match in snippet view article find links to article
cells to Treg suppression. GITR is in high interest as one of the immune checkpoint molecules that have potential in cancer treatment. GITR signaling
Sum activity of peripheral deiodinases (4,201 words) [view diff] exact match in snippet view article find links to article
be the reason for variations of SPINA-GD in subjects treated with immune checkpoint inhibitors for cancer as well. Endocrine disruptors may have pronounced
Michal Schwartz (2,304 words) [view diff] exact match in snippet view article find links to article
using a form of immunotherapy by modestly blocking the inhibitory immune checkpoint PD1/PD-L1 pathway.[citation needed] This treatment drives an immune-dependent
The Cancer Genome Atlas (7,468 words) [view diff] exact match in snippet view article find links to article
KRAS, ARID1A, and PTEN genes; amplification of CD274 and PDCD1LG2 immune checkpoint genes; alterations to genes including MED1, ERBB3, CASP8, HLA-A, and
Oligoclonal antibody (1,209 words) [view diff] exact match in snippet view article find links to article
PD1/PD-L1, ...) . The only oligoclonal antibody treatment against immune checkpoint currently approved is the cocktail of nivolumab (anti-PD1 antibody)
Devil facial tumour disease (5,984 words) [view diff] exact match in snippet view article find links to article
DFTD may impact the host immune system directly. Several studies of immune checkpoint molecules, such as PD-1 and PD-L1, have been undertaken in devils
Elizabeth Jaffee (1,022 words) [view diff] exact match in snippet view article find links to article
tolerance to cancers. These include utilizing treatments like novel immune checkpoint inhibitors and cancer vaccines. Jaffee is a major leader in cancer
KLRG1 (1,599 words) [view diff] exact match in snippet view article find links to article
by MHC class I molecules. KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector
James A. Wells (2,036 words) [view diff] case mismatch in snippet view article find links to article
of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1". Journal of the American Chemical Society. 143 (2):
Yu Dechao (658 words) [view diff] exact match in snippet view article find links to article
January 9, 2019. Ansell, S. M. (2019). "Sintilimab: Another effective immune checkpoint inhibitor in classical Hodgkin lymphoma". The Lancet. Haematology
ALK positive lung cancer (1,280 words) [view diff] exact match in snippet view article find links to article
clinical trials), developed by Nuvalent. Although treatment with immune checkpoint inhibitors has proved effective with some types of non-small cell
Dendritic cell (3,972 words) [view diff] exact match in snippet view article find links to article
contribute to the success of cancer immunotherapies, for example with the immune checkpoint blocker anti-PD-1. Altered function of dendritic cells is also known
Roy S. Herbst (1,334 words) [view diff] exact match in snippet view article find links to article
his colleagues at Yale did early research on the presence of the immune checkpoint protein PD-L1 in tumors that may dictate response to the immunotherapy
Oncolytic virus (8,503 words) [view diff] exact match in snippet view article find links to article
brand name Oncorine. With advances in cancer immunotherapy such as immune checkpoint inhibitors, increased attention has been given to using oncolytic
Viralytics (2,428 words) [view diff] no match in snippet view article find links to article
oncolytic immunotherapeutic agent, CAVATAK (coxsackievirus A21) and immune-checkpoint blockade significantly reduces tumor growth and improves survival
Indole-3-acetic acid (2,765 words) [view diff] case mismatch in snippet view article find links to article
Martina; Opitz, Christiane A. (2020-08-17). "IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression". Cell. 182
Affimer (2,484 words) [view diff] exact match in snippet view article find links to article
development to tackle cancer, both via CAR-T cell therapy and as immune checkpoint inhibitors. Early studies using ex vivo human samples showed low immunogenicity
PBRM1 (1,300 words) [view diff] exact match in snippet view article find links to article
among advanced ccRCC cases with PBRM1 mutations when treated with immune checkpoint inhibitors, there is still debate about the utility of PBRM1 status
Colorectal cancer (16,273 words) [view diff] exact match in snippet view article find links to article
which are developed by 10-15% of people with CRC. Immunotherapy with immune checkpoint inhibitors has been found to be useful for a type of colorectal cancer
HLA-G (2,627 words) [view diff] exact match in snippet view article find links to article
counterparts due to it having a more limited polymorphism. HLA-G is a major immune checkpoint, meaning it downregulates the immune system's response. Soluble HLA-G
Infliximab (3,937 words) [view diff] case mismatch in snippet view article find links to article
"Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical
Triple-negative breast cancer (3,411 words) [view diff] exact match in snippet view article find links to article
(ASCO) for metastatic TNBC: mTNBC +PD-L1: 1st line: offered chemo + immune checkpoint inhibitor mTNBC -PD-L1: 1st line: single-agent chemo; 3rd line: sacituzumab
Renal cell carcinoma (10,894 words) [view diff] exact match in snippet view article find links to article
Tony S K; Soo, Ross A (2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet Oncology. 18 (12): e731–e741. doi:10
Diffuse midline glioma (2,460 words) [view diff] exact match in snippet view article find links to article
agents are under investigation. Immunotherapy with beta-interferon and immune checkpoint inhibitors has also had little effect in trials. Neoepitope specific
Dan Theodorescu (902 words) [view diff] exact match in snippet view article find links to article
subtype in bladder tumors, called “C3”, shown to predict response to immune checkpoint therapy. "Dan Theodorescu | Staff Biographies | Cedars-Sinai Cancer
Prostate cancer (8,879 words) [view diff] exact match in snippet view article find links to article
have defective DNA damage repair benefit from treatment with the immune checkpoint inhibitor drug pembrolizumab and PARP inhibitors, namely olaparib
Trevor Lawley (2,000 words) [view diff] exact match in snippet view article find links to article
2022). "'Know thyself' – host factors influencing cancer response to immune checkpoint inhibitors". The Journal of Pathology. 257 (4): 513–525. doi:10.1002/path
Adjuvant therapy (4,529 words) [view diff] exact match in snippet view article find links to article
observation, improves overall survival. Newer trials incorporating immune checkpoint inhibitors such as the inhibitors to programmed death 1 (PD-1) and
Allergic rhinitis (5,347 words) [view diff] no match in snippet view article find links to article
allergic rhinitis onset in children. On the other hand, CTLA-4 is an immune-checkpoint protein that helps mediate and control the body's immune response
Amelanotic melanoma (3,232 words) [view diff] exact match in snippet view article find links to article
involvement of lymph nodes. Targeted therapies and systemic therapy using immune checkpoint inhibitors might be necessary. Both ipilimumab and nivolumab have
Antoni Ribas (professor) (1,194 words) [view diff] exact match in snippet view article
combination of two targeted inhibitors that block the BRAF mutation and an immune checkpoint inhibitor drug as their initial treatment. He was again honored for
Imugene (831 words) [view diff] exact match in snippet view article find links to article
produce an anticancer effect similar to Keytruda, Opdivo and the other immune checkpoint inhibitor monoclonal antibodies that are transforming treatment of
Jung-Min Lee (865 words) [view diff] no match in snippet view article find links to article
[2][3] Lee’s clinical trial is the first to test the modulation of immune-checkpoint activity by increasing the antigenic microenvironment with active
Camillo Ricordi (1,133 words) [view diff] case mismatch in snippet view article find links to article
and Biotech News. May 11, 2017. Williams R (November 15, 2017). "Immune Checkpoint Found Lacking in Type 1 Diabetes". The Scientist. "2015 Redesign -
Monoclonal antibody therapy (4,064 words) [view diff] exact match in snippet view article find links to article
PMID 26784573. Sharma P, Allison JP (April 2015). "The future of immune checkpoint therapy". Science. 348 (6230): 56–61. Bibcode:2015Sci...348...56S
Imugene (831 words) [view diff] exact match in snippet view article find links to article
produce an anticancer effect similar to Keytruda, Opdivo and the other immune checkpoint inhibitor monoclonal antibodies that are transforming treatment of
James L. Gulley (1,490 words) [view diff] exact match in snippet view article find links to article
prostate cancer. His studies involved the use of cancer vaccine and immune checkpoint inhibitors or other strategies to enhance vaccine-mediated killing
Non-small-cell lung cancer (5,301 words) [view diff] exact match in snippet view article find links to article
Calais F, Marchal C, Westeel V (April 2021). "Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with
Toni Choueiri (1,497 words) [view diff] exact match in snippet view article find links to article
Allen, E. M. (February 16, 2018). "Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma". Science. 359 (6377):
Autogene cevumeran (428 words) [view diff] exact match in snippet view article find links to article
patients who had undergone surgery then received atezolizumab, an immune checkpoint inhibitor. 16 of the patients on atezolizumab then received autogene
Julie Brahmer (857 words) [view diff] exact match in snippet view article find links to article
tenure at JHU, Brahmer participated as a researcher on a trial for an immune checkpoint inhibitor drug called MDX-1106 (nivolumab). In 2010, she oversaw the
UK Coronavirus Cancer Monitoring Project (4,522 words) [view diff] exact match in snippet view article find links to article
J.; Lee, Alvin; Purshouse, Karin; Middleton, Gary (2020-09-01). "Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19
Stomach cancer (8,156 words) [view diff] case mismatch in snippet view article find links to article
Myeloid-Derived Suppressor Cell Compartment for Inducing Responsiveness to Immune Checkpoint Blockade Is Best Limited to Specific Subtypes of Gastric Cancers"
Merkel-cell carcinoma (5,542 words) [view diff] case mismatch in snippet view article find links to article
Topalian, Suzanne L.; Drake, Charles G.; Pardoll, Drew M. (April 2015). "Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy". Cancer
Synthetic lethality (2,802 words) [view diff] exact match in snippet view article find links to article
PMC 3744994. PMID 23836560. Villadolid J, Amin A (October 2015). "Immune checkpoint inhibitors in clinical practice: update on management of immune-related
Immune tolerance (6,022 words) [view diff] exact match in snippet view article find links to article
1038/nrc3606. PMC 4010142. PMID 24213474. Ramsay AG (August 2013). "Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity". British
Dannielle Engle (3,282 words) [view diff] case mismatch in snippet view article find links to article
A., Schmid, M.C. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. (2018) Cancer Research
Merck & Co. (9,284 words) [view diff] exact match in snippet view article find links to article
Merck & Co. will bring in CM-24, an antibody designed to block the immune checkpoint CEACAM1. In January 2016, Merck announced two new partnerships; the
Cholangiocarcinoma (7,639 words) [view diff] exact match in snippet view article find links to article
as detected by an FDA-approved test. Durvalumab, (Imfinzi) is an immune checkpoint inhibitor that blocks the PD-L1 protein on the surface of immune cells
Epitopoietic Research Corporation (1,654 words) [view diff] exact match in snippet view article find links to article
the ability to combine it with bevacizumab, and potentially with immune checkpoint inhibitors – an option that will allow more powerful immune activation
Miriam Merad (1,875 words) [view diff] exact match in snippet view article find links to article
enriched in immunoregulatory molecules (mregDCs) that limit responses to immune checkpoint blockade, and the niches in tumors in which mregDCs operate. The Merad
Immune system (13,491 words) [view diff] exact match in snippet view article find links to article
Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731–e741. doi:10
BeiGene (2,448 words) [view diff] exact match in snippet view article find links to article
PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy". Biochemical and Biophysical Research Communications. 527
Membrane estrogen receptor (1,985 words) [view diff] exact match in snippet view article find links to article
estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade". eLife. 7. doi:10.7554/eLife.31770. ISSN 2050-084X. PMC 5770157
Hepatocellular carcinoma (9,623 words) [view diff] exact match in snippet view article find links to article
treatments for advanced HCC. A host of additional targeted therapies and immune checkpoint inhibitors have been found to be effective against this disease. For
Horizontal transfer of mitochondria (1,777 words) [view diff] exact match in snippet view article find links to article
GTPase signaling repressed TNT formation and improves the effect of immune checkpoint inhibitor in a breast cancer model. Mitochondrial transfer occurs
Association for Molecular Pathology (1,194 words) [view diff] case mismatch in snippet view article find links to article
et al. Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: Guideline From the College of American Pathologists
Breast cancer (16,954 words) [view diff] exact match in snippet view article find links to article
talazoparib) for those with mutations that inactivate BRCA1 or BRCA2. The immune checkpoint inhibitor antibody atezolizumab for those whose tumors express PD-L1
Vijay Kuchroo (2,061 words) [view diff] exact match in snippet view article find links to article
Yu, Shengnan; Wu, Kongming; Luo, Suxia (6 November 2019). "Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4". Molecular Cancer. 18 (1):
Antineoplastic resistance (3,900 words) [view diff] exact match in snippet view article find links to article
chemotherapy. In breast cancer, particularly in the triple-negative subtype, immune checkpoint blockade has been used successfully in metastatic cases and neoadjuvant
List of people from Houston (4,143 words) [view diff] exact match in snippet view article find links to article
Nobel Prize winner in Physiology or Medicine for the invention of immune checkpoint inhibition Malcolm Brenner, Former Director of the Center for Cell
Sankar Ghosh (2,448 words) [view diff] exact match in snippet view article find links to article
Ghosh, S. (2017) NF-κB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer. Cell 170: 1096–1108. Dainichi, T., Hayden, M.S., Park,
TREM2 (4,092 words) [view diff] case mismatch in snippet view article find links to article
Jiang J, Ma Q, Wang Y, et al. (2021). "TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy". Frontiers in Immunology. 12:
Regulatory T cell (9,560 words) [view diff] no match in snippet view article find links to article
antibody ipilimumab was approved for patients with advanced melanoma. Immune-checkpoint molecule PD-1 inhibits activation of both conventional T cells and
Crystal Mackall (2,782 words) [view diff] exact match in snippet view article find links to article
clinical trial of recombinant human interleukin-7, led studies of immune checkpoint inhibitors in pediatric cancers and studied a role for bone marrow
Cellular adoptive immunotherapy (2,149 words) [view diff] exact match in snippet view article find links to article
immunotherapy and dendritic cell therapy. Although immunotherapy with immune checkpoint blockade and targeted therapy was used to treat and improve the survival
Peter Karl Sorger (3,097 words) [view diff] exact match in snippet view article find links to article
"Combinatorial benefit without synergy in recent clinical trials of immune checkpoint inhibitors". pp. 2020–01.31.20019604. medRxiv 10.1101/2020.01.31.20019604v2
Raffaele De Caterina (955 words) [view diff] exact match in snippet view article find links to article
for the short-term prediction of cardiac outcomes in patients on immune checkpoint inhibitors". European Journal of Clinical Investigation. 51 (4): e13400
POLD1 (7,977 words) [view diff] case mismatch in snippet view article find links to article
S2CID 5338516. Bouffet E, Larouche V, Campbell BB, et al. (March 2016). "Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From
Jeffrey Bluestone (1,885 words) [view diff] exact match in snippet view article find links to article
James P. Allison to target CTLA-4 resulted in the development of immune checkpoint therapies also known as immunotherapy.[citation needed] This led to
Nathan Chen (16,608 words) [view diff] case mismatch in snippet view article find links to article
Indeterminate Potential (CHIP) is an Independent Risk Factor for Immune Checkpoint Inhibitor Myocarditis [abstract]". Journal of the American College
Epithelioid sarcoma (5,913 words) [view diff] exact match in snippet view article find links to article
examining cellular therapy for epithelioid sarcoma specifically. Immune checkpoint inhibitors are approved for use in many types of cancer, though there
Bradley J. Monk (3,280 words) [view diff] exact match in snippet view article find links to article
Stéphanie L.; Secord, Angeles A.; Monk, Bradley (2016). "The role of immune checkpoint inhibition in the treatment of ovarian cancer" (PDF). Gynecologic
Peter Fecci (2,318 words) [view diff] exact match in snippet view article find links to article
immune escape in a variety of cancers. He was the first to explore immune checkpoint blockade as an immunotherapeutic strategy in brain tumor models: “Systemic
Treatment of lung cancer (6,487 words) [view diff] exact match in snippet view article find links to article
Tony S K; Soo, Ross A (2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet Oncology. 18 (12): e731–e741. doi:10
List of University of California, Berkeley faculty (15,272 words) [view diff] exact match in snippet view article find links to article
sparking a revolution in cancer therapy through (his) discovery of immune checkpoint blockade" Robert G. Bergman – professor of chemistry (1977–present)
George Lau (1,642 words) [view diff] no match in snippet view article find links to article
3 clinical trials (HIMALAYA STUDY) established dual blockade with immune-checkpoint inhibitors (CTLA-4 and PD-1/L1) STRIDE (Single T Regular Interval
Sanjiv Sam Gambhir (4,744 words) [view diff] case mismatch in snippet view article find links to article
Mayer A.T., Gambhir S.S. (2018). "Reply: Optimizing Strategies for Immune Checkpoint Imaging with Immuno-PET in Preclinical Study". Journal of Nuclear
2023 in science (44,436 words) [view diff] exact match in snippet view article find links to article
metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment". Cell. 186 (9): 1846–1862.e26. doi:10.1016/j
Focused ultrasound for intracranial drug delivery (4,384 words) [view diff] exact match in snippet view article find links to article
antibody (aPD-L1) Brainstem Glioma FUS and intranasally-injected aPD-L1 (immune checkpoint inhibitor) to cross BBB and enhance delivery to mouse brainstem Trastuzumab
Outline of cardiology (7,304 words) [view diff] exact match in snippet view article find links to article
toxicity (leads to dilated cardiomyopathy). Another is trastuzumab. Immune checkpoint inhibitors can also lead to cardiotoxicity. Diuretics – The primary
EPIC-Seq (6,303 words) [view diff] no match in snippet view article find links to article
subtypes of DLBCL, DLBCL COO detection, programmed death-ligand 1 immune-checkpoint inhibition response prediction against advanced NSCLC cases, and prognostic
Immunoliposome therapy (3,045 words) [view diff] exact match in snippet view article find links to article
the effectiveness of PDS0101 in combination with pembrolizumab, an immune checkpoint inhibitor (sold under the brand name Keytruda). The study is funded
Stichodactyla toxin (8,630 words) [view diff] exact match in snippet view article find links to article
blocking the KV1.3 channel with the ShK domain, MMP-23 may serve as an immune checkpoint to reduce excessive T cell activation during an immune response. In