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searching for Immune checkpoint 194 found (247 total)

Mucosal melanoma (435 words) [view diff] exact match in snippet view article find links to article

capacity to improve survival in clinical and observational studies, immune checkpoint inhibitors (e.g., pembrolizumab) have been tested in mucosal melanomas

Camrelizumab (136 words) [view diff] exact match in snippet view article find links to article

Camrelizumab (SHR-1210) (INN) is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma

Timeline of immunology (2,209 words) [view diff] exact match in snippet view article find links to article

P. Allison is the first to describe the function of the critical immune checkpoint CTLA-4 1995 – Regulatory T cells (Shimon Sakaguchi) 1995 – First Dendritic

Checkpoint inhibitor induced colitis (1,704 words) [view diff] exact match in snippet view article find links to article

or vomiting warrant evaluation with upper endoscopy. Treatment of immune checkpoint inhibitor colitis is based on severity, as defined by the grade of

HLA-G (3,097 words) [view diff] exact match in snippet view article find links to article

counterparts due to it having a more limited polymorphism. HLA-G is a major immune checkpoint, meaning it downregulates the immune system's response. Soluble HLA-G

Abscopal effect (1,126 words) [view diff] exact match in snippet view article find links to article

were extremely rare throughout the 20th century, the clinical use of immune checkpoint blocking antibodies such as ipilimumab or pembrolizumab has greatly

Compugen Ltd. (1,956 words) [view diff] exact match in snippet view article find links to article

as an agriscience division in 1999. PVRIG is a novel B7/CD28-like immune checkpoint target candidate. In June 2016, Compugen announced the selection of

Bladder cancer (6,140 words) [view diff] exact match in snippet view article find links to article

year from diagnosis. These people are treated with chemotherapy and immune checkpoint inhibitors, followed by enfortumab vedotin. Around 500,000 people

Arlene Sharpe (252 words) [view diff] exact match in snippet view article find links to article

collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the

Plinabulin (504 words) [view diff] exact match in snippet view article find links to article

chemotherapy-induced neutropenia and for anti-cancer effects in combination with immune checkpoint inhibitors and in KRAS mutated tumors. Plinabulin blocks the polymerization

Graduate School of Medicine and Faculty of Medicine, Kyoto University (529 words) [view diff] exact match in snippet view article find links to article

in Physiology or Medicine in 2018 for his discovery and theory of immune checkpoint inhibitors. In 1899, College of Medicine (医科大学) and its hospital (now

Immunologic checkpoint (385 words) [view diff] exact match in snippet view article find links to article

An immune checkpoint regulator is a modulator of the immune system, that allows initiation of a productive immune response and prevents the onset of autoimmunity

TNFAIP8L2 (421 words) [view diff] exact match in snippet view article find links to article

preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism. TNFAIP8L2 is a member of

DNA mismatch repair (4,179 words) [view diff] exact match in snippet view article find links to article

mismatch repair mutations were initially observed to associate with immune checkpoint blockade efficacy in a study examining responders to anti-PD1. The

Sialic acid binding ig-like lectin 15 (313 words) [view diff] exact match in snippet view article find links to article

demonstrated that antibody blockade of the Siglec-15/sialic acid glycol-immune checkpoint axis can act as a potential treatment for breast cancer bone metastasis

Tak Wah Mak (1,659 words) [view diff] exact match in snippet view article find links to article

published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint

Myocarditis-myositis-myasthenia gravis overlap syndrome (277 words) [view diff] exact match in snippet view article find links to article

immune-related adverse event primarily associated with the use of immune checkpoint inhibitors (ICIs). These ICIs, which have been incorporated into the

Nanobiotix (1,803 words) [view diff] no match in snippet view article find links to article

Nanobiotix is a biotechnology company that uses nanomedicine to develop new radiotherapy techniques for cancer patients. The company is headquartered in

Immunotherapy (6,093 words) [view diff] case mismatch in snippet view article find links to article

(2015). "Immune Checkpoint Inhibitors". Progress in Tumor Research. 42: 55–66. doi:10.1159/000437178. ISBN 978-3-318-05589-4. PMID 26382943. "Immune Checkpoint

Gestational choriocarcinoma (2,873 words) [view diff] exact match in snippet view article find links to article

reduce the risk of resistance are currently being researched, such as immune checkpoint inhibitors. Studies of gestational choriocarcinoma demonstrate an

Flotetuzumab (195 words) [view diff] exact match in snippet view article find links to article

therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors". Curr. Opin. Hematol. 25 (2): 136–145. doi:10.1097/MOH

CD40 (protein) (2,905 words) [view diff] exact match in snippet view article

in preclinical glioma models, and in fact affect the efficacy of immune checkpoint blockade. This is likely due to the high mutational burden most of

Ana Anderson (504 words) [view diff] exact match in snippet view article find links to article

investigated TIM-3, an immune checkpoint receptor that is involved with immunity to tumors. The blockade of immune checkpoint receptors is a recognized

Nivolumab (4,859 words) [view diff] case mismatch in snippet view article find links to article

Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors". Hormone and Metabolic Research. 51 (3): 145–156. doi:10

Samalizumab (124 words) [view diff] exact match in snippet view article find links to article

chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200". Journal for Immunotherapy of Cancer. 7 (1): 227. doi:10

NT5E (2,273 words) [view diff] exact match in snippet view article find links to article

et al. (January 2020). "2B-mediated feedforward circuit enforces an immune checkpoint". Nature Communications. 11 (1): 515. doi:10.1038/s41467-019-14060-x

Lung cancer (9,743 words) [view diff] exact match in snippet view article find links to article

therapy are combined with newer targeted molecular therapies and immune checkpoint inhibitors. All lung cancer treatment regimens are combined with lifestyle

Tissue-resident memory T cell (3,066 words) [view diff] exact match in snippet view article find links to article

upregulated immune checkpoint receptors. This suggests, that most of the tumor TRM show an exhausted phenotype which may be saved by immune checkpoint inhibitor

Molecular oncology (1,208 words) [view diff] exact match in snippet view article find links to article

cellular and molecular level. Some regulatory proteins, specifically immune checkpoint inhibitors, have been found to reduce the ability of T cells to multiply

Combinatorial ablation and immunotherapy (1,140 words) [view diff] case mismatch in snippet view article find links to article

Oklu, Rahmi; Sheth, Rahul A. (2015). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response

Fibrolamellar hepatocellular carcinoma (2,191 words) [view diff] exact match in snippet view article find links to article

which include extended information on patient outcomes, efficacy of immune checkpoint inhibitors, efficacy of specific drugs and understanding the basis

Cryoimmunotherapy (1,280 words) [view diff] case mismatch in snippet view article find links to article

Cryotherapy". Mehta Amol (2016). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response"

GPER (3,997 words) [view diff] exact match in snippet view article find links to article

GPER agonist, LNS8801, as monotherapy and in combination with the immune checkpoint inhibitor, pembrolizumab, for the treatment of multiple solid tumor

James P. Allison (2,142 words) [view diff] exact match in snippet view article find links to article

that target T-cell inhibitory pathways, which have been labeled as "immune checkpoint therapies". This work ultimately led to the clinical development of

Adenocarcinoma of the lung (4,606 words) [view diff] exact match in snippet view article find links to article

mutations). Therapeutic approaches combining multiple immune checkpoint inhibitors or one immune checkpoint inhibitors and a cytotoxic agent are undergoing

Myasthenia gravis (8,951 words) [view diff] exact match in snippet view article find links to article

drugs, clindamycin, polymyxin B, and nitrofurantoin. Immune checkpoint inhibitors: Immune checkpoint inhibitors promote certain types of autoimmune responses

P-selectin glycoprotein ligand-1 (2,455 words) [view diff] case mismatch in snippet view article find links to article

Otero DC, Magaña J, Bosenberg MW, et al. (May 2016). "PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion". Immunity. 44 (5): 1190–1203

Paraneoplastic syndrome (2,358 words) [view diff] exact match in snippet view article find links to article

[citation needed] Paraneoplastic neurological syndromes may be related immune checkpoint inhibitors (ICIs), one of the underlying causes in inflammatory central

Tyrosine sulfation (747 words) [view diff] exact match in snippet view article find links to article

binding to P-selectin but also enables its pH-selective binding to the immune checkpoint protein VISTA. In 2006, an article was published in the Journal of

Melanoma (16,418 words) [view diff] exact match in snippet view article find links to article

countries, but today (2024) the most common adjuvant treatment is immune checkpoint inhibitor treatment for up to a year post-surgery. In the early 2000s

Jiangsu Hengrui (475 words) [view diff] exact match in snippet view article find links to article

has run clinical trials on anti-cancer drugs such as: An anti-PD-1 immune checkpoint inhibitor camrelizumab for hepatocellular carcinoma; A nonsteroidal

Sarcoma (4,140 words) [view diff] exact match in snippet view article find links to article

still under investigation is the use of cancer immunotherapy (e.g., immune checkpoint inhibitors like anti-PD1, anti-PDL1, and anti-CTLA4 agents) to treat

Antibody Solutions (956 words) [view diff] case mismatch in snippet view article find links to article

of Agonist and Antagonist Human Monoclonal Antibodies Against an Immune Checkpoint Target from the H2L2 Mouse Generation and Selection of Human Monoclonal

Adagrasib (768 words) [view diff] exact match in snippet view article find links to article

disease has progressed on or after platinum-based chemotherapy and an immune checkpoint inhibitor, given either concurrently or sequentially. The FDA granted

Cancer vaccine (3,229 words) [view diff] exact match in snippet view article find links to article

Since tumors often evolve mechanisms to suppress the immune system, immune checkpoint blockade has recently received a lot of attention as a potential treatment

PD-L1 (3,052 words) [view diff] exact match in snippet view article find links to article

et al. (December 2019). "EBV microRNA-BHRF1-2-5p targets the 3'UTR of immune checkpoint ligands PD-L1 and PD-L2". Blood. 134 (25): 2261–2270. doi:10.1182/blood

Ipilimumab (4,338 words) [view diff] exact match in snippet view article find links to article

Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731 – e741. doi:10

CD160 (896 words) [view diff] exact match in snippet view article find links to article

molecules. CD160 is a ligand for HVEM, and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti- PD-1 antibodies

MARCO (2,234 words) [view diff] exact match in snippet view article find links to article

pathways, including immunosuppressive TAMs, T-cell infiltration, and immune checkpoint molecules. Higher infiltration of tumor tissues by macrophages was

Cancer immunology (3,766 words) [view diff] exact match in snippet view article find links to article

cells. monoclonal anti-CTLA4 and anti-PD-1 antibodies are called immune checkpoint inhibitors: CTLA-4 is a receptor upregulated on the membrane of activated

Tumor-infiltrating lymphocytes (2,759 words) [view diff] exact match in snippet view article find links to article

in Lynch syndrome. Also, TILs are associated with most effective immune checkpoint inhibitor therapy in GI cancers. They are an important prognostic

Monalizumab (142 words) [view diff] exact match in snippet view article find links to article

Burg SH, Vivier E (October 2019). "Monalizumab: inhibiting the novel immune checkpoint NKG2A". Journal for Immunotherapy of Cancer. 7 (1): 263. doi:10

Thymoglobulin (833 words) [view diff] exact match in snippet view article find links to article

vitro, including CD25, GITR, and CTLA-4 (aka CD152, functions as immune checkpoint, downregulates immune response). Recent research has suggested that

G1 Therapeutics (2,101 words) [view diff] exact match in snippet view article find links to article

inhibitor, enhances the efficacy of combination chemotherapy and immune checkpoint inhibitor treatment in preclinical models, American Association for

Tislelizumab (1,323 words) [view diff] exact match in snippet view article find links to article

1186/s12890-023-02755-3. PMC 10704633. PMID 38066549. Liu S, Dou L, Li S (2024). "Immune checkpoint inhibitors versus chemotherapy as second-line therapy for advanced

Silvia Formenti (489 words) [view diff] exact match in snippet view article find links to article

lung cancer and melanoma. She showed that in the presence of an immune checkpoint blockade (e.g. CTLA-4) an irradiated metastatic tumor can become an

List of human clusters of differentiation (492 words) [view diff] exact match in snippet view article find links to article

presenting cells Binds: ICOS on T cells CD276 CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of

Kidney cancer (5,187 words) [view diff] exact match in snippet view article find links to article

treatments are often followed by everolimus, axitinib, and sorafenib. Immune checkpoint inhibitors are also in trials for kidney cancer, and some have gained

TNFAIP8 (474 words) [view diff] exact match in snippet view article find links to article

et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99:

Non-small-cell lung cancer (5,532 words) [view diff] exact match in snippet view article find links to article

Calais F, Marchal C, Westeel V (April 2021). "Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with

Laurence Zitvogel (1,622 words) [view diff] exact match in snippet view article find links to article

gut to the tumors, thereby compromising the anticancer effects of immune checkpoint inhibitors (ICIs). Accompanying this, she saw that the relocation

CD83 (2,181 words) [view diff] case mismatch in snippet view article find links to article

Zinser E, et al. (17 April 2020). "The CD83 Molecule - An Important Immune Checkpoint". Frontiers in Immunology. 11: 721. doi:10.3389/fimmu.2020.00721.

Adoptive cell transfer (3,797 words) [view diff] exact match in snippet view article find links to article

remove inhibitory pathways that block T-cell responses, known as immune checkpoint therapy. As of 2015 the technique had expanded to treat cervical cancer

APC Activator (525 words) [view diff] exact match in snippet view article find links to article

clinical trials in combination with chemotherapy (paclitaxel), or immune checkpoint inhibitors, including the PD-1 monoclonal antibody pembrolizumab,

APC Activator (525 words) [view diff] exact match in snippet view article find links to article

clinical trials in combination with chemotherapy (paclitaxel), or immune checkpoint inhibitors, including the PD-1 monoclonal antibody pembrolizumab,

Cell ablation (617 words) [view diff] exact match in snippet view article find links to article

review of treatment modalities and the evidence for combination with immune checkpoint inhibitors". Translational Lung Cancer Research. 10 (6): 2842–2857

Pneumonitis (2,035 words) [view diff] case mismatch in snippet view article find links to article

(2025-04-12). "A Systematic Review of Pneumonitis Following Treatment with Immune Checkpoint Inhibitors and Radiotherapy". Biomedicines. 13 (4): 946. doi:10

PKM2 (4,865 words) [view diff] case mismatch in snippet view article find links to article

(2017-10-13). "Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors". Frontiers in Immunology. 8: 1300

CD200 (1,806 words) [view diff] exact match in snippet view article find links to article

chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200". Journal for Immunotherapy of Cancer. 7 (1): 227. doi:10

Michal Schwartz (2,126 words) [view diff] exact match in snippet view article find links to article

using a form of immunotherapy by modestly blocking the inhibitory immune checkpoint PD1/PD-L1 pathway.[citation needed] This treatment drives an immune-dependent

The Breakthrough: Immunotherapy and the Race to Cure Cancer (606 words) [view diff] exact match in snippet view article find links to article

believers in the form of regulatory approval of CTLA-4, PD-1, and PD-L1 immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies. The book

Zabadinostat (1,094 words) [view diff] exact match in snippet view article find links to article

and enhancing anti-tumour activity, especially when combined with immune checkpoint inhibitors (ICIs), such as anti-PD-1 and anti-CTLA4. In addition,

Transitional cell carcinoma (1,970 words) [view diff] exact match in snippet view article find links to article

Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731 – e741. doi:10

Autoimmune hypophysitis (1,645 words) [view diff] exact match in snippet view article find links to article

this may be an underestimate, especially due to the recent use of immune checkpoint inhibitors for cancer treatments, which have endocrine side effects

MD Anderson Cancer Center (5,247 words) [view diff] case mismatch in snippet view article find links to article

treat brain tumors. 2018: Nobel Prize in Physiology or Medicine for Immune Checkpoint Therapy James P. Allison, professor and chair of immunology at MD

SillaJen (763 words) [view diff] exact match in snippet view article find links to article

Pharmaceuticals to conduct a combination study with Pexa-Vec and Regeneron's immune checkpoint inhibitor cemiplimab for renal cell carcinoma. In July 2017, SillaJen

Chemoimmunotherapy (1,033 words) [view diff] exact match in snippet view article find links to article

levels of suppressive cytokines (TGF-β, TNF, IL-10), expression of immune checkpoint molecules (PD-L1, B7-H4), and other alterations that help the tumor

Warren Alpert Foundation Prize (385 words) [view diff] exact match in snippet view article find links to article

collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the

Head and neck cancer (11,867 words) [view diff] exact match in snippet view article find links to article

activates the immune system to fight cancer. One type of immunotherapy, immune checkpoint blockade, binds to and blocks inhibitory signals on immune cells to

Vedolizumab (2,383 words) [view diff] case mismatch in snippet view article find links to article

"Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical

Dong Chen (451 words) [view diff] exact match in snippet view article find links to article

Liu, Dongfang; Dong, Chen (August 2017). "Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function". Cell

American Association for Cancer Research (1,246 words) [view diff] exact match in snippet view article find links to article

on targeted therapy, and cancer immunotherapy research including immune checkpoint blockade and Chimeric Antigen Receptor (CAR) T-cell therapy. The AACR

Adrenal crisis (4,908 words) [view diff] exact match in snippet view article find links to article

immunotherapy, have been linked to an increased risk of adrenal crisis. Immune checkpoint inhibitors are known to cause endocrine problems, including hypophysitis

Asunercept (778 words) [view diff] exact match in snippet view article find links to article

BJ (2018). "Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism". Cancer Immunol Immunother. 68 (5): 835–847. Bibcode:2017NatCo

Sintilimab (385 words) [view diff] exact match in snippet view article find links to article

March 2019. Ansell SM (January 2019). "Sintilimab: another effective immune checkpoint inhibitor in classical Hodgkin lymphoma". The Lancet. Haematology

Dostarlimab (3,221 words) [view diff] case mismatch in snippet view article find links to article

ClinicalTrials.gov Green AK, Feinberg J, Makker V (March 2020). "A Review of Immune Checkpoint Blockade Therapy in Endometrial Cancer". American Society of Clinical

T cell (9,237 words) [view diff] exact match in snippet view article find links to article

by T cells. Many experiments and clinical trials have focused on immune checkpoint blockers in cancer therapy, with some of these approved as valid therapies

Myeloid-derived suppressor cell (3,266 words) [view diff] exact match in snippet view article find links to article

environment and is necessary for mitochondrial biosynthesis), PDL-1 (an immune checkpoint protein) and LOX1 (promotes fatty acid consumption and fatty acid

TNFRSF18 (2,117 words) [view diff] exact match in snippet view article find links to article

cells to Treg suppression. GITR is in high interest as one of the immune checkpoint molecules that have potential in cancer treatment. GITR signaling

Richard Scolyer (864 words) [view diff] exact match in snippet view article find links to article

Xinyu; Rawson, Robert V. (27 February 2025). "Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma". Nature Medicine: 1–10.

Sotorasib (2,073 words) [view diff] exact match in snippet view article find links to article

non-small cell lung cancer with disease progression after receiving an immune checkpoint inhibitor and/or platinum-based chemotherapy. The major outcomes measured

Elizabeth Jaffee (1,129 words) [view diff] exact match in snippet view article find links to article

tolerance to cancers. These include utilizing treatments like novel immune checkpoint inhibitors and cancer vaccines. Jaffee is a major leader in cancer

Oligoclonal antibody (1,204 words) [view diff] exact match in snippet view article find links to article

PD1/PD-L1, ...). The only oligoclonal antibody treatment against immune checkpoint currently approved is the cocktail of nivolumab (anti-PD1 antibody)

Antihistamine (3,300 words) [view diff] exact match in snippet view article find links to article

cancer therapies has suggested that when consumed in conjunction with immune checkpoint inhibitors some may influence the response of subjects to that particular

James A. Wells (2,042 words) [view diff] case mismatch in snippet view article find links to article

of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1". Journal of the American Chemical Society. 143 (2):

Taminadenant (254 words) [view diff] case mismatch in snippet view article find links to article

Hernandez DC, Allard B, et al. (July 2017). "A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte

Sanford Burnham Prebys (1,966 words) [view diff] case mismatch in snippet view article find links to article

"Clinical Evidence Supporting Therapeutic Potential of Activating the Immune Checkpoint Receptor BTLA in SLE". ACR Meeting Abstracts. Retrieved 2025-05-02

The Cancer Genome Atlas (7,468 words) [view diff] exact match in snippet view article find links to article

KRAS, ARID1A, and PTEN genes; amplification of CD274 and PDCD1LG2 immune checkpoint genes; alterations to genes including MED1, ERBB3, CASP8, HLA-A, and

Yu Dechao (660 words) [view diff] exact match in snippet view article find links to article

January 9, 2019. Ansell, S. M. (2019). "Sintilimab: Another effective immune checkpoint inhibitor in classical Hodgkin lymphoma". The Lancet. Haematology

KLRG1 (1,599 words) [view diff] exact match in snippet view article find links to article

by MHC class I molecules. KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector

Devil facial tumour disease (5,995 words) [view diff] exact match in snippet view article find links to article

DFTD may impact the host immune system directly. Several studies of immune checkpoint molecules, such as PD-1 and PD-L1, have been undertaken in devils

Renal cell carcinoma (10,959 words) [view diff] exact match in snippet view article find links to article

Tony S K; Soo, Ross A (2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet Oncology. 18 (12): e731 – e741. doi:10

Adegramotide (336 words) [view diff] case mismatch in snippet view article find links to article

2024-08-13. "A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Solid Tumors". clinicaltrials

Sum activity of peripheral deiodinases (4,723 words) [view diff] exact match in snippet view article find links to article

be the reason for variations of SPINA-GD in subjects treated with immune checkpoint inhibitors for cancer as well. Endocrine disruptors may have pronounced

Roy S. Herbst (1,334 words) [view diff] exact match in snippet view article find links to article

his colleagues at Yale did early research on the presence of the immune checkpoint protein PD-L1 in tumors that may dictate response to the immunotherapy

Oncolytic virus (8,636 words) [view diff] exact match in snippet view article find links to article

brand name Oncorine. With advances in cancer immunotherapy such as immune checkpoint inhibitors, increased attention has been given to using oncolytic

Dendritic cell (4,110 words) [view diff] exact match in snippet view article find links to article

contribute to the success of cancer immunotherapies, for example with the immune checkpoint blocker anti-PD-1. Altered function of dendritic cells is also known

Viralytics (2,428 words) [view diff] no match in snippet view article find links to article

oncolytic immunotherapeutic agent, CAVATAK (coxsackievirus A21) and immune-checkpoint blockade significantly reduces tumor growth and improves survival

Bone metastasis (2,714 words) [view diff] exact match in snippet view article find links to article

(January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy

Affimer (2,484 words) [view diff] exact match in snippet view article find links to article

development to tackle cancer, both via CAR-T cell therapy and as immune checkpoint inhibitors. Early studies using ex vivo human samples showed low immunogenicity

PBRM1 (1,300 words) [view diff] exact match in snippet view article find links to article

among advanced ccRCC cases with PBRM1 mutations when treated with immune checkpoint inhibitors, there is still debate about the utility of PBRM1 status

Indole-3-acetic acid (2,769 words) [view diff] case mismatch in snippet view article find links to article

Martina; Opitz, Christiane A. (2020-08-17). "IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression". Cell. 182

Camillo Ricordi (1,133 words) [view diff] case mismatch in snippet view article find links to article

and Biotech News. May 11, 2017. Williams R (November 15, 2017). "Immune Checkpoint Found Lacking in Type 1 Diabetes". The Scientist. "2015 Redesign -

ALK positive lung cancer (1,597 words) [view diff] exact match in snippet view article find links to article

clinical trials), developed by Nuvalent. Although treatment with immune checkpoint inhibitors has proved effective with some types of non-small cell

Infliximab (4,035 words) [view diff] case mismatch in snippet view article find links to article

"Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical

Georgina Long (1,092 words) [view diff] exact match in snippet view article find links to article

PMID 32025007. Carlino, Matteo S; Larkin, James; Long, Georgina V (2021). "Immune checkpoint inhibitors in melanoma". The Lancet. 398 (10304): 1002–1014. doi:10

Nonsense-mediated decay (2,900 words) [view diff] exact match in snippet view article find links to article

frameshift-derived neoantigens only contribute to the response to immune checkpoint inhibition if they arise from mutations in parts of the genome that

Cervical cancer (12,823 words) [view diff] exact match in snippet view article find links to article

bleeding in women with advanced cervical cancer. Immunotherapy with immune checkpoint inhibitors, such as pembrolizumab (Keytruda), has also been approved

Ubiquitin ligase (4,428 words) [view diff] case mismatch in snippet view article find links to article

of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1". Journal of the American Chemical Society. 143 (2):

Colorectal cancer (16,748 words) [view diff] exact match in snippet view article find links to article

which are developed by 10–15% of people with CRC. Immunotherapy with immune checkpoint inhibitors is useful for a type of colorectal cancer with mismatch

Dan Theodorescu (902 words) [view diff] exact match in snippet view article find links to article

subtype in bladder tumors, called “C3”, shown to predict response to immune checkpoint therapy. "Dan Theodorescu | Staff Biographies | Cedars-Sinai Cancer

Triple-negative breast cancer (3,423 words) [view diff] exact match in snippet view article find links to article

(ASCO) for metastatic TNBC: mTNBC +PD-L1: 1st line: offered chemo + immune checkpoint inhibitor mTNBC -PD-L1: 1st line: single-agent chemo; 3rd line: sacituzumab

Nathan Chen (17,922 words) [view diff] case mismatch in snippet view article find links to article

Indeterminate Potential (CHIP) is an Independent Risk Factor for Immune Checkpoint Inhibitor Myocarditis [abstract]". Journal of the American College

Nanomaterials and cancer (670 words) [view diff] exact match in snippet view article find links to article

immunotherapies.[citation needed] They can serve as carriers for immune checkpoint inhibitors, vaccines, or other immunomodulatory agents. Intracellular

Antoni Ribas (professor) (1,194 words) [view diff] exact match in snippet view article

combination of two targeted inhibitors that block the BRAF mutation and an immune checkpoint inhibitor drug as their initial treatment. He was again honored for

James L. Gulley (1,490 words) [view diff] exact match in snippet view article find links to article

prostate cancer. His studies involved the use of cancer vaccine and immune checkpoint inhibitors or other strategies to enhance vaccine-mediated killing

Jung-Min Lee (852 words) [view diff] no match in snippet view article find links to article

agents. Lee’s clinical trial is the first to test the modulation of immune-checkpoint activity by increasing the antigenic microenvironment with active

Amelanotic melanoma (3,232 words) [view diff] exact match in snippet view article find links to article

involvement of lymph nodes. Targeted therapies and systemic therapy using immune checkpoint inhibitors might be necessary. Both ipilimumab and nivolumab have

Adjuvant therapy (4,805 words) [view diff] exact match in snippet view article find links to article

observation, improves overall survival. Newer trials incorporating immune checkpoint inhibitors such as the inhibitors to programmed death 1 (PD-1) and

Imugene (831 words) [view diff] exact match in snippet view article find links to article

produce an anticancer effect similar to Keytruda, Opdivo and the other immune checkpoint inhibitor monoclonal antibodies that are transforming treatment of

Diffuse midline glioma (2,793 words) [view diff] exact match in snippet view article find links to article

agents are under investigation. Immunotherapy with beta-interferon and immune checkpoint inhibitors has also had little effect in trials. Neoepitope specific

Prasinezumab (255 words) [view diff] exact match in snippet view article find links to article

Farouk Z (September 2024). "Limitations and potential strategies of immune checkpoint blockade in age-related neurodegenerative disorders". J Physiol Sci

Monoclonal antibody therapy (4,170 words) [view diff] exact match in snippet view article find links to article

PMID 26784573. Sharma P, Allison JP (April 2015). "The future of immune checkpoint therapy". Science. 348 (6230): 56–61. Bibcode:2015Sci...348...56S

Allergic rhinitis (5,823 words) [view diff] no match in snippet view article find links to article

allergic rhinitis onset in children. On the other hand, CTLA-4 is an immune-checkpoint protein that helps mediate and control the body's immune response

Ann Richmond (587 words) [view diff] exact match in snippet view article find links to article

tumor formation and tumor growth. Her team has shown how combining immune checkpoint inhibitors with therapies that target CXCR2, the PI3K/AKT pathway

Autogene cevumeran (428 words) [view diff] exact match in snippet view article find links to article

patients who had undergone surgery then received atezolizumab, an immune checkpoint inhibitor. 16 of the patients on atezolizumab then received autogene

Julie Brahmer (857 words) [view diff] exact match in snippet view article find links to article

tenure at JHU, Brahmer participated as a researcher on a trial for an immune checkpoint inhibitor drug called MDX-1106 (nivolumab). In 2010, she oversaw the

Lymphatic system (7,530 words) [view diff] exact match in snippet view article find links to article

anti-tumor response when patients are treated with immunotherapy such as immune checkpoint blockade treatment. Lymphoid tissue associated with the lymphatic

Siglec (3,968 words) [view diff] exact match in snippet view article find links to article

(January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy

Toni Choueiri (1,694 words) [view diff] exact match in snippet view article find links to article

Allen, E. M. (February 16, 2018). "Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma". Science. 359 (6377):

UK Coronavirus Cancer Monitoring Project (4,522 words) [view diff] exact match in snippet view article find links to article

J.; Lee, Alvin; Purshouse, Karin; Middleton, Gary (2020-09-01). "Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19

Trevor Lawley (2,446 words) [view diff] exact match in snippet view article find links to article

2022). "'Know thyself' – host factors influencing cancer response to immune checkpoint inhibitors". The Journal of Pathology. 257 (4): 513–525. doi:10.1002/path

Dannielle Engle (3,282 words) [view diff] case mismatch in snippet view article find links to article

A., Schmid, M.C. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. (2018) Cancer Research

Jostel's TSH index (2,106 words) [view diff] exact match in snippet view article find links to article

index may predict the development of hypophysitis due to therapy with immune checkpoint inhibitors, e. g. ipilimumab. Thyroid function tests Thyrotroph Thyroid

Stomach cancer (7,985 words) [view diff] case mismatch in snippet view article find links to article

Myeloid-Derived Suppressor Cell Compartment for Inducing Responsiveness to Immune Checkpoint Blockade Is Best Limited to Specific Subtypes of Gastric Cancers"

Cosibelimab (399 words) [view diff] exact match in snippet view article find links to article

prior treatment with anti-PD-1/PD-L1 blocking antibodies or other immune checkpoint inhibitor therapy, uncontrolled or significant cardiovascular disease

Acinic cell carcinoma (5,761 words) [view diff] exact match in snippet view article find links to article

typically display increased immune cell infiltration, upregulation of immune checkpoint molecules, and heightened genomic instability, potentially explaining

Fibrolamellar Registry (681 words) [view diff] case mismatch in snippet view article find links to article

"Clinical Outcomes in Fibrolamellar Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors". Cancers. 14 (21): 5347. doi:10.3390/cancers14215347.

Synthetic lethality (2,804 words) [view diff] exact match in snippet view article find links to article

PMC 3744994. PMID 23836560. Villadolid J, Amin A (October 2015). "Immune checkpoint inhibitors in clinical practice: update on management of immune-related

Merkel-cell carcinoma (5,546 words) [view diff] case mismatch in snippet view article find links to article

Topalian, Suzanne L.; Drake, Charles G.; Pardoll, Drew M. (April 2015). "Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy". Cancer

ZBP1 (2,535 words) [view diff] exact match in snippet view article find links to article

cell death in cancer-associated fibroblasts and effectively reverse immune checkpoint blockade (ICB) resistance in mouse models of melanoma. ZBP1 is also

Prostate cancer (9,190 words) [view diff] exact match in snippet view article find links to article

have defective DNA damage repair benefit from treatment with the immune checkpoint inhibitor drug pembrolizumab and PARP inhibitors, namely olaparib

Cholangiocarcinoma (7,708 words) [view diff] exact match in snippet view article find links to article

as detected by an FDA-approved test. Durvalumab, (Imfinzi) is an immune checkpoint inhibitor that blocks the PD-L1 protein on the surface of immune cells

Immune tolerance (6,091 words) [view diff] exact match in snippet view article find links to article

1038/nrc3606. PMC 4010142. PMID 24213474. Ramsay AG (August 2013). "Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity". British

Immune tolerance (6,091 words) [view diff] exact match in snippet view article find links to article

1038/nrc3606. PMC 4010142. PMID 24213474. Ramsay AG (August 2013). "Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity". British

Merck & Co. (9,748 words) [view diff] exact match in snippet view article find links to article

Merck & Co. will bring in CM-24, an antibody designed to block the immune checkpoint CEACAM1. In January 2016, Merck announced two new partnerships; the

Epitopoietic Research Corporation (1,649 words) [view diff] exact match in snippet view article find links to article

the ability to combine it with bevacizumab, and potentially with immune checkpoint inhibitors – an option that will allow more powerful immune activation

Miriam Merad (2,046 words) [view diff] exact match in snippet view article find links to article

enriched in immunoregulatory molecules (mregDCs) that limit responses to immune checkpoint blockade, and the niches in tumors in which mregDCs operate. The Merad

Immune system (13,520 words) [view diff] exact match in snippet view article find links to article

Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731 – e741. doi:10

BeOne (2,340 words) [view diff] exact match in snippet view article find links to article

PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy". Biochemical and Biophysical Research Communications. 527

Jeffrey Bluestone (1,123 words) [view diff] exact match in snippet view article find links to article

James P. Allison to target CTLA-4 resulted in the development of immune checkpoint therapies also known as immunotherapy.[citation needed] This led to

Breast cancer (15,802 words) [view diff] exact match in snippet view article find links to article

talazoparib) for those with mutations that inactivate BRCA1 or BRCA2. The immune checkpoint inhibitor antibody atezolizumab for those whose tumors express PD-L1

Membrane estrogen receptor (1,985 words) [view diff] exact match in snippet view article find links to article

estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade". eLife. 7. doi:10.7554/eLife.31770. ISSN 2050-084X. PMC 5770157

Hepatocellular carcinoma (10,606 words) [view diff] exact match in snippet view article find links to article

compared to placebo. A host of additional targeted therapies and immune checkpoint inhibitors have been found to be effective. For instance, in the recent

Association for Molecular Pathology (1,194 words) [view diff] case mismatch in snippet view article find links to article

et al. Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: Guideline From the College of American Pathologists

Antineoplastic resistance (3,844 words) [view diff] exact match in snippet view article find links to article

chemotherapy. In breast cancer, particularly in the triple-negative subtype, immune checkpoint blockade has been used successfully in metastatic cases and neoadjuvant

Vijay Kuchroo (2,061 words) [view diff] exact match in snippet view article find links to article

Yu, Shengnan; Wu, Kongming; Luo, Suxia (6 November 2019). "Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4". Molecular Cancer. 18 (1):

TREM2 (4,094 words) [view diff] case mismatch in snippet view article find links to article

Jiang J, Ma Q, Wang Y, et al. (2021). "TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy". Frontiers in Immunology. 12:

Regulatory T cell (9,482 words) [view diff] no match in snippet view article find links to article

antibody ipilimumab was approved for patients with advanced melanoma. Immune-checkpoint molecule PD-1 inhibits activation of both conventional T cells and

List of people from Houston (4,426 words) [view diff] exact match in snippet view article find links to article

Nobel Prize winner in Physiology or Medicine for the invention of immune checkpoint inhibition Malcolm Brenner, former director of the Center for Cell

Sankar Ghosh (2,448 words) [view diff] exact match in snippet view article find links to article

Ghosh, S. (2017) NF-κB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer. Cell 170: 1096–1108. Dainichi, T., Hayden, M.S., Park,

Lingyin Li (1,080 words) [view diff] exact match in snippet view article find links to article

extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint Cell reports, 43(5), 114209. Merad, M., Posey, A. D., Jr, Olivero

Raffaele De Caterina (955 words) [view diff] exact match in snippet view article find links to article

for the short-term prediction of cardiac outcomes in patients on immune checkpoint inhibitors". European Journal of Clinical Investigation. 51 (4): e13400

ERAP1 (3,912 words) [view diff] exact match in snippet view article find links to article

to ERAP1 inhibition, as monotherapy, or in combination with PD-1 immune checkpoint Inhibitor Libtayo® (cemiplimab). GRCh38: Ensembl release 89: ENSG00000164307

Crystal Mackall (3,269 words) [view diff] exact match in snippet view article find links to article

clinical trial of recombinant human interleukin-7, led studies of immune checkpoint inhibitors in pediatric cancers and studied a role for bone marrow

Peter Karl Sorger (3,097 words) [view diff] exact match in snippet view article find links to article

"Combinatorial benefit without synergy in recent clinical trials of immune checkpoint inhibitors". pp. 2020–01.31.20019604. medRxiv 10.1101/2020.01.31.20019604v2

Cellular adoptive immunotherapy (2,170 words) [view diff] exact match in snippet view article find links to article

immunotherapy and dendritic cell therapy. Although immunotherapy with immune checkpoint blockade and targeted therapy was used to treat and improve the survival

Sugemalimab (912 words) [view diff] exact match in snippet view article find links to article

ligand 1 (PD-L1; cluster of differentiation 274; CD274) and possesses immune checkpoint inhibitory and antineoplastic properties. When administered, sugemalimab

Bradley J. Monk (3,247 words) [view diff] exact match in snippet view article find links to article

Stéphanie L.; Secord, Angeles A.; Monk, Bradley (2016). "The role of immune checkpoint inhibition in the treatment of ovarian cancer" (PDF). Gynecologic

POLD1 (7,954 words) [view diff] case mismatch in snippet view article find links to article

S2CID 5338516. Bouffet E, Larouche V, Campbell BB, et al. (March 2016). "Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From

Epithelioid sarcoma (5,913 words) [view diff] exact match in snippet view article find links to article

examining cellular therapy for epithelioid sarcoma specifically. Immune checkpoint inhibitors are approved for use in many types of cancer, though there

Peter Fecci (2,322 words) [view diff] exact match in snippet view article find links to article

immune escape in a variety of cancers. He was the first to explore immune checkpoint blockade as an immunotherapeutic strategy in brain tumor models: “Systemic

List of University of California, Berkeley faculty (15,213 words) [view diff] exact match in snippet view article find links to article

sparking a revolution in cancer therapy through (his) discovery of immune checkpoint blockade" Robert G. Bergman – professor of chemistry (1977–present)

Sanjiv Sam Gambhir (4,769 words) [view diff] case mismatch in snippet view article find links to article

Mayer A.T., Gambhir S.S. (2018). "Reply: Optimizing Strategies for Immune Checkpoint Imaging with Immuno-PET in Preclinical Study". Journal of Nuclear

Treatment of lung cancer (6,590 words) [view diff] exact match in snippet view article find links to article

Tony S K; Soo, Ross A (2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet Oncology. 18 (12): e731 – e741. doi:10

List of National Inventors Hall of Fame inductees (15,291 words) [view diff] case mismatch in snippet view article find links to article

Retrieved October 11, 2023. "NIHF Inductee James Allison Invented Immune Checkpoint Blockade Therapy". www.invent.org. National Inventors Hall of Fame

George Lau (1,642 words) [view diff] no match in snippet view article find links to article

3 clinical trials (HIMALAYA STUDY) established dual blockade with immune-checkpoint inhibitors (CTLA-4 and PD-1/L1) STRIDE (Single T Regular Interval

Outline of cardiology (7,309 words) [view diff] exact match in snippet view article find links to article

toxicity (leads to dilated cardiomyopathy). Another is trastuzumab. Immune checkpoint inhibitors can also lead to cardiotoxicity. Diuretics – The primary

Focused ultrasound for intracranial drug delivery (4,384 words) [view diff] exact match in snippet view article find links to article

antibody (aPD-L1) Brainstem Glioma FUS and intranasally-injected aPD-L1 (immune checkpoint inhibitor) to cross BBB and enhance delivery to mouse brainstem Trastuzumab

Immunoliposome therapy (3,063 words) [view diff] exact match in snippet view article find links to article

the effectiveness of PDS0101 in combination with pembrolizumab, an immune checkpoint inhibitor (sold under the brand name Keytruda). The study is funded

Stichodactyla toxin (8,640 words) [view diff] exact match in snippet view article find links to article

blocking the KV1.3 channel with the ShK domain, MMP-23 may serve as an immune checkpoint to reduce excessive T cell activation during an immune response. In

2023 in science (44,592 words) [view diff] exact match in snippet view article find links to article

metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment". Cell. 186 (9): 1846–1862.e26. doi:10.1016/j

Lifileucel (2,262 words) [view diff] exact match in snippet view article find links to article

treatments, including targeted drugs and immunotherapies such as immune checkpoint inhibitors (ICI). Patients with advanced or metastatic melanoma often

EPIC-Seq (6,409 words) [view diff] no match in snippet view article find links to article

subtypes of DLBCL, DLBCL COO detection, programmed death-ligand 1 immune-checkpoint inhibition response prediction against advanced NSCLC cases, and prognostic