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searching for T cell 202 found (4039 total)

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DNA vaccine (8,381 words) [view diff] no match in snippet view article find links to article

Antigen presentation by both MHC class I and class II molecules Polarise T-cell response toward type 1 or type 2 Immune response focused on the antigen
T-cell surface glycoprotein CD3 epsilon chain (1,591 words) [view diff] exact match in snippet view article find links to article
CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays
T-cell surface glycoprotein CD3 zeta chain (615 words) [view diff] no match in snippet view article find links to article
T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in
TAL1 (1,404 words) [view diff] no match in snippet view article find links to article
T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in
CD3D (1,049 words) [view diff] no match in snippet view article find links to article
T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene. CD3D has been shown to interact with CD8A. CD3 (immunology)
CD3G (1,024 words) [view diff] exact match in snippet view article find links to article
T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene. T cell antigen receptor (TCR) is associated on the
TLX3 (837 words) [view diff] no match in snippet view article find links to article
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene. RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox
TLX1 (1,104 words) [view diff] no match in snippet view article find links to article
T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11. TLX1 has been shown to interact
TAL2 (573 words) [view diff] no match in snippet view article find links to article
T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene. TAL2 is a member of the basic helix-loop-helix
Stevens–Johnson syndrome (5,843 words) [view diff] exact match in snippet view article find links to article
leukocyte antigen (i.e. HLA) serotypes (i.e. genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues
PD-L1 (2,846 words) [view diff] exact match in snippet view article find links to article
delivers a signal that inhibits TCR-mediated activation of IL-2 production and T cell proliferation. The mechanism involves inhibition of ZAP70 phosphorylation
Pralatrexate (634 words) [view diff] no match in snippet view article find links to article
peripheral T-cell lymphoma (PTCL). Pralatrexate was approved for medical use in the United States in September 2009, as the first treatment for Peripheral T-cell
TCF7 (723 words) [view diff] exact match in snippet view article find links to article
transcription factor 7 (T-cell specific, HMG-box)". van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1
Primate T-lymphotropic virus (2,998 words) [view diff] no match in snippet view article find links to article
T-lymphotropic viruses (STLVs). PTLVs are named for their ability to cause adult T-cell leukemia/lymphoma, but in the case of HTLV-1 it can also cause a demyelinating
CD8A (1,282 words) [view diff] no match in snippet view article find links to article
within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting
TLX2 (409 words) [view diff] no match in snippet view article find links to article
T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene. TLX2 has been shown to interact with YWHAH. GRCh38: Ensembl
GATA3 (3,740 words) [view diff] no match in snippet view article find links to article
Eléouet JF, Labastie MC, Chrétien S, Mattéi MG, Roméo PH (Jul 1991). "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family"
CD69 (2,275 words) [view diff] exact match in snippet view article find links to article
and many other cell types in the immune system. It is also implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs. The
CD1b (769 words) [view diff] no match in snippet view article find links to article
T-cell surface glycoprotein CD1b is a protein that in humans is encoded by the CD1B gene. CD1b belongs to group 1 of CD1 family of transmembrane glycoproteins
Belinostat (360 words) [view diff] no match in snippet view article find links to article
tumors. It was approved in July 2014 by the US FDA to treat peripheral T-cell lymphoma. In 2007 preliminary results were released from the Phase II clinical
CD43 (1,283 words) [view diff] no match in snippet view article find links to article
function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Defects in the CD43 molecule are associated with the development
Pathophysiology of HIV/AIDS (1,841 words) [view diff] exact match in snippet view article find links to article
T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4+ T cell counts rebound. A good CD8+ T
PDCD1LG2 (2,040 words) [view diff] exact match in snippet view article find links to article
in immune tolerance and autoimmunity. Both PD-L1 and PD-L2 can inhibit T cell proliferation and inflammatory cytokine production. Blocking PD-L2 has been
Co-stimulation (1,920 words) [view diff] exact match in snippet view article find links to article
T cell. This interaction promotes and enhances the TCR signaling, but can also be bi-directional. The co-stimulatory signal is necessary for T cell proliferation
FOXN1 (834 words) [view diff] no match in snippet view article find links to article
keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy
IL2RA (2,548 words) [view diff] exact match in snippet view article find links to article
CD8+ and CD4+ T lymphocytes), where it is considered to be a marker of T cell activation. Additionally, expression of the IL-2 receptor alpha subunit
Nelarabine (277 words) [view diff] no match in snippet view article find links to article
chemotherapy medication used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Nelarabine is a
LILRB1 (1,162 words) [view diff] exact match in snippet view article find links to article
(Dec 1993). "A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation". Cellular Immunology. 152 (2): 371–82. doi:10.1006/cimm.1993
Lymphocyte function-associated antigen 1 (946 words) [view diff] exact match in snippet view article find links to article
leukocytes. Additionally, LFA-1 is involved in the process of cytotoxic T cell mediated killing as well as antibody mediated killing by granulocytes and
LIGHT (protein) (1,807 words) [view diff] exact match in snippet view article
a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response". Journal of Immunology.
Denileukin diftitox (237 words) [view diff] no match in snippet view article find links to article
the U.S. Food and Drug Administration (FDA) for treatment of Cutaneous T-cell lymphoma (CTCL). There is some evidence tying it to vision loss, and in
ZBTB7B (570 words) [view diff] exact match in snippet view article find links to article
DNA-templated regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of transcription
CD74 (2,221 words) [view diff] exact match in snippet view article find links to article
transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74
Mogamulizumab (653 words) [view diff] exact match in snippet view article find links to article
or refractory CCR4+ adult T-cell leukemia/lymphoma (ATCLL) and in 2014, for relapsed or refractory CCR4+ cutaneous T cell lymphoma (CTCL). The latter
Adenosine deaminase (3,014 words) [view diff] no match in snippet view article find links to article
associated with pulmonary inflammation, thymic cell death, and defective T-cell receptor signaling. Conversely, mutations causing this enzyme to be overexpressed
RUNX1 (3,631 words) [view diff] no match in snippet view article find links to article
Speck, NA (June 1993). "Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor". Mol Cell
Alopecia mucinosa (626 words) [view diff] no match in snippet view article find links to article
Alopecia mucinosa, also known as Follicular mucinosis, Mucinosis follicularis, Pinkus' follicular mucinosis, and Pinkus' follicular mucinosis–benign primary
HIV/AIDS research (5,105 words) [view diff] exact match in snippet view article find links to article
virus particles bud from an infected T cell, enter the blood/extracellular fluid, and then infect another T cell. A 2015 study proposes a more realistic
Feline leukemia virus (2,713 words) [view diff] no match in snippet view article find links to article
license for a new treatment aid termed Lymphocyte T-Cell Immunomodulator (LTCI). Lymphocyte T-Cell Immunomodulator is manufactured and distributed exclusively
HIV-associated pruritus (63 words) [view diff] no match in snippet view article find links to article
skin, that occurs in up to 30% of HIV infected people, occurs when the T-cell count drops below 400 per cubic mm.: 417  Skin lesion James, William D.;
CD1E (818 words) [view diff] no match in snippet view article find links to article
T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene. This gene encodes a member of the CD1 family
Primary cutaneous CD-30 positive T-cell lymphoproliferative disorders (90 words) [view diff] no match in snippet view article find links to article
Primary cutaneous CD-30 positive T-cell lymphoproliferative disorders are a family of skin-localized extranodal lymphoid neoplasms that develop from mature
Aplastic anemia (4,363 words) [view diff] exact match in snippet view article find links to article
white blood cells attack the bone marrow. Acquired aplastic anemia is a T-cell mediated autoimmune disease, in which regulatory T cells are decreased and
Prostvac (705 words) [view diff] exact match in snippet view article find links to article
and attack prostate cancer cells by triggering a specific and targeted T cell immune response to cancer cells that express the tumor-associated antigen
Pleomorphic T-cell lymphoma (75 words) [view diff] no match in snippet view article find links to article
Pleomorphic T-cell lymphoma (also known as "Non-mycosis fungoides CD30− pleomorphic small/medium sized cutaneous T-cell lymphoma") is a cutaneous condition
NFATC2 (1,445 words) [view diff] exact match in snippet view article find links to article
protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors
Beta-2 microglobulin (2,117 words) [view diff] exact match in snippet view article find links to article
presentation of exogenous peptide antigen via MHC class I, TAP-dependent T cell differentiation in thymus immune system process interferon-gamma-mediated
Mir-711 microRNA precursor family (283 words) [view diff] no match in snippet view article find links to article
mechanisms. miR-711 is able to distinguish between malignant cutaneous T-cell lymphomas and benign skin disorders with high accuracy. miR-711 has been
Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma (64 words) [view diff] no match in snippet view article find links to article
Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma is a cutaneous condition that usually presents as solitary or generalized plaques, nodules
Human T-lymphotropic virus 2 (1,254 words) [view diff] no match in snippet view article find links to article
human retroviruses. Of the four subtypes, HTLV-2 may be linked to Cutaneous T-cell lymphoma (CTCL). In one study involving cultured lymphocytes from patients
PTPRJ (1,336 words) [view diff] exact match in snippet view article find links to article
present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation
Acute leukemia (398 words) [view diff] no match in snippet view article find links to article
lymphoblastic leukemia including T-cell acute lymphoblastic leukemia. Types of T-cell acute lymphoblastic leukemia include adult T-cell leukemia/lymphoma and (precursor)
TCF/LEF family (2,038 words) [view diff] exact match in snippet view article find links to article
The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like
TCL (GTPase) (269 words) [view diff] no match in snippet view article
is unrelated to TCL1A, a proto-oncogene implicated in the development of T-Cell Leukemias. TCL1A Ridley A. (2006). "Rho GTPases and actin dynamics in membrane
Hematologic disease (537 words) [view diff] no match in snippet view article find links to article
lymphoma Splenic marginal zone lymphoma Hepatosplenic T-cell lymphoma Angioimmunoblastic T-cell lymphoma (AILT) Myelomas Multiple myeloma Waldenström
IGSF2 (594 words) [view diff] exact match in snippet view article find links to article
et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies". J. Immunol.
Visceral leishmaniasis (7,880 words) [view diff] exact match in snippet view article find links to article
antigen specific T cell proliferation and IFN-γ secretion. Co-culture of T cells with B cells decreased the percentage of CD4+ T cell proliferation and
ITGAE (1,537 words) [view diff] exact match in snippet view article find links to article
fraction of splenic marginal zone lymphomas, and enteropathy-associated T cell lymphoma. The chief ligand for αEβ7 is E-cadherin, a cellular adhesion molecule
Bexarotene (1,467 words) [view diff] exact match in snippet view article find links to article
antineoplastic (anti-cancer) agent used for the treatment of cutaneous T cell lymphoma (CTCL). It is a third-generation retinoid. It was approved by the
Asymptomatic carrier (2,261 words) [view diff] no match in snippet view article find links to article
tuberculosis, and COVID-19, although the latter is often associated with "robust T-cell immunity" in more than a quarter of patients studied. While the mechanism
TBX21 (2,366 words) [view diff] exact match in snippet view article find links to article
phenotypes (Th2 and Th17). In a typical scenario it is thought that IFNg and T cell receptor (TCR) signalling initiates the expression of Tbet, and once TCR
Interleukin 35 (1,669 words) [view diff] exact match in snippet view article find links to article
IL-35 can block the development of Th1 and Th17 cells by limiting early T cell proliferation. IL-35 is a dimeric protein composed of IL-12α and IL-27β
ICAM-1 (2,409 words) [view diff] no match in snippet view article find links to article
immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. ICAM-1 is a transmembrane protein possessing an amino-terminus
Timeline of immunology (2,182 words) [view diff] no match in snippet view article find links to article
Ralph M. Steinman 1974 – Immune Network Hypothesis (Niels Jerne) 1974 – T-cell restriction to MHC (Rolf Zinkernagel and (Peter C. Doherty) 1975 – Generation
List of distinct cell types in the adult human body (704 words) [view diff] exact match in snippet view article find links to article
granulocyte and precursors??? Mast cell Helper T cell Regulatory T cell Cytotoxic T cell Natural killer T cell B cell(/lymphocyte) Left atrium, left ventricle
Parapsoriasis (196 words) [view diff] no match in snippet view article find links to article
develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma. The word "parapsoriasis" was formed in 1902. The parapsoriasis
CCL19 (1,396 words) [view diff] exact match in snippet view article find links to article
also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds
CCR2 (1,920 words) [view diff] exact match in snippet view article find links to article
alpha-beta T cell proliferation homeostasis of number of cells within a tissue positive regulation of inflammatory response positive regulation of T cell activation
CXCL13 (518 words) [view diff] exact match in snippet view article find links to article
origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas
Interleukin-6 receptor (1,438 words) [view diff] exact match in snippet view article find links to article
Yamamoto M, Yamamoto N (1994). "Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear
HLA-A (3,411 words) [view diff] no match in snippet view article find links to article
stabilizes interactions between the t-cell receptor on cytotoxic (CD8+) T-lymphocytes and the Class I MHC. The T-cell receptor also has the potential to
Lenzilumab (1,120 words) [view diff] exact match in snippet view article find links to article
pathway driving the serious and life-threatening chimeric antigen receptor T cell (CAR-T) associated cytokine release syndrome (CRS). GM-CSF is produced by
CD83 (2,266 words) [view diff] exact match in snippet view article find links to article
differentiated cTECs called thymic nurse cells are tested for function of their αβ T cell receptor (TCR); a nonreactive TCR leads to thymocyte death by neglect. Successful
Terminal deoxynucleotidyl transferase (3,518 words) [view diff] no match in snippet view article find links to article
Studies using TdT knockout mice have found drastic reductions (10-fold) in T-cell receptor (TCR) diversity compared with that of normal, or wild-type, systems
CCR10 (1,257 words) [view diff] exact match in snippet view article find links to article
receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. GRCh38: Ensembl release 89: ENSG00000184451
Lipid raft (6,643 words) [view diff] case mismatch in snippet view article find links to article
T Cell Activation". Immunity. 9 (2): 239–46. doi:10.1016/S1074-7613(00)80606-8. PMID 9729044. Brdička, Tomáš; Černý, Jan; Hořejší, Václav (1998). "T Cell
TCF7L2 (4,358 words) [view diff] no match in snippet view article find links to article
Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans,
Interferon gamma (6,477 words) [view diff] exact match in snippet view article find links to article
histocompatibility complex (MHC) class II expression on APCs; induce CD8+ cytotoxic T cell differentiation, activation, and proliferation; and activate macrophages
CD37 (1,539 words) [view diff] no match in snippet view article find links to article
Z (August 2000). "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular
LYL1 (633 words) [view diff] exact match in snippet view article find links to article
(July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif"
NFATC1 (1,107 words) [view diff] exact match in snippet view article find links to article
a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins
Thymosin (697 words) [view diff] no match in snippet view article find links to article
categorized as biological response modifiers. Thymosins are important for proper T-cell development and differentiation. The discovery of thymosins in the mid 1960s
HLA-DR (2,293 words) [view diff] no match in snippet view article find links to article
generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as
Ornithine decarboxylase (2,082 words) [view diff] no match in snippet view article find links to article
with AMXT 1501 depleted the polyamine pool and inhibited T-cell proliferation and suppressed T-cell inflammation. Recent studies have shown the importance
GLI3 (1,196 words) [view diff] exact match in snippet view article find links to article
regulation of alpha-beta T cell differentiation in utero embryonic development transcription, DNA-templated negative thymic T cell selection positive regulation
Tuberculous lymphadenitis (773 words) [view diff] exact match in snippet view article find links to article
cells and (Langhans cells), surrounded by epithelioid cells aggregates, T cell lymphocytes and fibroblasts. Granulomatous tubercules eventually develop
CD1A (988 words) [view diff] no match in snippet view article find links to article
structural information available in the PDB for UniProt: P06126 (Human T-cell surface glycoprotein CD1a) at the PDBe-KB. Melián A, Beckman EM, Porcelli
GLI3 (1,196 words) [view diff] exact match in snippet view article find links to article
regulation of alpha-beta T cell differentiation in utero embryonic development transcription, DNA-templated negative thymic T cell selection positive regulation
Tuberculous lymphadenitis (773 words) [view diff] exact match in snippet view article find links to article
cells and (Langhans cells), surrounded by epithelioid cells aggregates, T cell lymphocytes and fibroblasts. Granulomatous tubercules eventually develop
CD1A (988 words) [view diff] no match in snippet view article find links to article
structural information available in the PDB for UniProt: P06126 (Human T-cell surface glycoprotein CD1a) at the PDBe-KB. Melián A, Beckman EM, Porcelli
CD46 (1,159 words) [view diff] exact match in snippet view article find links to article
regulation of gene expression positive regulation of T cell proliferation positive regulation of memory T cell differentiation complement activation, classical
Akiko Iwasaki (1,743 words) [view diff] exact match in snippet view article find links to article
human papillomavirus, respiratory virus infections, influenza infection, T cell immunity, commensal bacteria, COVID-19, and long COVID. Iwasaki was elected
GPR15 (1,503 words) [view diff] exact match in snippet view article find links to article
physiological role remains elusive. It seems to play a role in homing of single T cell types to the colon. In human, GPR15 controls together with α4β7-integrin
Toxic shock syndrome (3,419 words) [view diff] exact match in snippet view article find links to article
II, on professional antigen presenting cells, with T-cell receptors, on T cells. In typical T-cell recognition, an antigen is taken up by an antigen-presenting
CCL20 (1,549 words) [view diff] exact match in snippet view article find links to article
resulting in increased regional CCL20 expression and subsequent pathogenic CD4+ T cell accumulation at the same spinal cord level. CCL20 expression was observed
Concanavalin A (2,270 words) [view diff] exact match in snippet view article find links to article
is known for its ability to stimulate mouse T-cell subsets giving rise to four functionally distinct T cell populations, including precursors to regulatory
B-cell maturation antigen (1,937 words) [view diff] exact match in snippet view article find links to article
preclinical and phase I clinical studies. A Phase 1b/2 study of JNJ-4528, a CAR-T cell therapy directed against BCMA in myeloma patients refractory to a proteasome
PTPN2 (1,202 words) [view diff] exact match in snippet view article find links to article
Nguyen TH, Coxe MA (2019). "PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity". Nat. Immunol. 20 (10): 1335–1347
60S ribosomal protein L14 (907 words) [view diff] no match in snippet view article find links to article
Hurwitz JL (1994). "Restricted usage of T-cell receptor V alpha sequence and variable-joining pairs after normal T-cell development and bone marrow transplantation"
CXCR3 (2,235 words) [view diff] exact match in snippet view article find links to article
in response to CCR3 ligands, thus enhancing the polarization of effector T cell recruitment. Binding of CXCL9, CXCL10, and CXCL11 to CXCR3 is able to elicit
Sonic hedgehog protein (7,133 words) [view diff] exact match in snippet view article find links to article
development bud outgrowth involved in lung branching limb bud formation T cell differentiation in thymus embryonic pattern specification positive regulation
Death receptor 3 (1,592 words) [view diff] exact match in snippet view article find links to article
splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms
Signs and symptoms of HIV/AIDS (3,356 words) [view diff] exact match in snippet view article find links to article
individual. AIDS, the final stage of HIV infection, is defined by low CD4+ T cell counts (fewer than 200 per μL), various opportunistic infections, cancers
TNFRSF18 (2,107 words) [view diff] exact match in snippet view article find links to article
on CD25+CD4+ regulatory T cells and its expression is upregulated on all T cell subsets after activation. GITR is also expressed on murine neutrophils and
60S ribosomal protein L6 (1,058 words) [view diff] no match in snippet view article find links to article
specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate
MAP2K4 (1,031 words) [view diff] exact match in snippet view article find links to article
liver formation. Analysis of chimeric mice identified a role for Map2k4 in T cell cytokine production and proliferation. Map2k4-deficient chimeric mice frequently
Jurkat cells (579 words) [view diff] exact match in snippet view article find links to article
line of human T lymphocyte cells that are used to study acute T cell leukemia, T cell signaling, and the expression of various chemokine receptors susceptible
Granulomatous slack skin (157 words) [view diff] no match in snippet view article find links to article
typically presents in middle-aged adults.: 735  It is a form of cutaneous T-cell lymphoma and a variant of mycosis fungoides. List of cutaneous conditions
Jurkat cells (579 words) [view diff] exact match in snippet view article find links to article
line of human T lymphocyte cells that are used to study acute T cell leukemia, T cell signaling, and the expression of various chemokine receptors susceptible
CEACAM1 (1,472 words) [view diff] exact match in snippet view article find links to article
extracellular region integral component of plasma membrane extracellular exosome T cell receptor complex cell-cell junction cell surface plasma membrane adherens
MAP2K4 (1,031 words) [view diff] exact match in snippet view article find links to article
liver formation. Analysis of chimeric mice identified a role for Map2k4 in T cell cytokine production and proliferation. Map2k4-deficient chimeric mice frequently
Fiona Powrie (1,118 words) [view diff] exact match in snippet view article find links to article
Here, she extended her earlier work in rats to mice and developed the "T cell transfer" model, one of the most prominent models of intestinal inflammation
Attenuated vaccine (4,240 words) [view diff] exact match in snippet view article find links to article
make antibodies, are activated in two ways: T cell-dependent and T-cell independent activation. In T-cell dependent activation of B cells, B cells first
Immunosenescence (3,555 words) [view diff] no match in snippet view article find links to article
with anergy and T-cell exhaustion, immunosenescence belongs among the major immune system dysfunctional states. However, while T-cell anergy is a reversible
Immunopathology (1,245 words) [view diff] exact match in snippet view article find links to article
antigen presentation, producing immunosuppressive molecules, and inhibiting T cell function. This can lead to the development and progression of cancer. Immunotherapy
PHF6 (1,101 words) [view diff] no match in snippet view article find links to article
also frequently mutated in human hematological malignancies, including T-cell acute lymphoblastic Leukemia (T-ALL) and Acute Myeloid Leukemia (AML) and
MEF2D (1,265 words) [view diff] exact match in snippet view article find links to article
Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases
Berlin Patient (1,619 words) [view diff] exact match in snippet view article find links to article
CD4 T cell count decline, and in another case due to a cancer diagnosis. Another cohort member is displaying clear evidence of declining CD4 T cell counts
Interleukin 23 (2,192 words) [view diff] case mismatch in snippet view article find links to article
Ancel CM, Coussens PM (2020). "paratuberculosis Drives an Innate Th17-Like T Cell Response Regardless of the Presence of Antigen-Presenting Cells". Frontiers
Mark M. Davis (668 words) [view diff] no match in snippet view article find links to article
supervised by Leroy E. Hood. Davis is well known for identifying the first T-cell receptor genes, which are responsible for T lymphocytes ability to "see"
Growth factor (1,131 words) [view diff] exact match in snippet view article find links to article
Interleukins IL-1- Cofactor for IL-3 and IL-6. Activates T cells. IL-2 – T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells
Perforin-1 (1,410 words) [view diff] no match in snippet view article find links to article
of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Perforin is thought to act
XCR1 (1,234 words) [view diff] exact match in snippet view article find links to article
spleen develop into XCR1+ DCs in the small intestine, T cell zones of Peyer's patches, and T cell zones and sinuses of mesenteric lymph nodes. XCR1+ DCs
IFNB1 (857 words) [view diff] exact match in snippet view article find links to article
(1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5
Interleukin-23 receptor (1,589 words) [view diff] exact match in snippet view article find links to article
Gram-negative bacterium positive regulation of T cell proliferation positive regulation of memory T cell differentiation positive regulation of interleukin-17
OR10G3 (379 words) [view diff] no match in snippet view article find links to article
Lenstra JA, Howard S, Shan W, Deshpande P, Hood L (Jun 1994). "The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and
OR4E2 (366 words) [view diff] no match in snippet view article find links to article
subfamily E, member 2". Koop BF, Rowen L, Wang K, et al. (1994). "The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and
Chromosome 14 (1,831 words) [view diff] exact match in snippet view article find links to article
protein TMEM260 TRAJ56: encoding protein T cell receptor alpha joining 56 TRAV12-2: encoding protein T cell receptor alpha variable 12-2 TSHR: thyroid
FUT7 (1,001 words) [view diff] no match in snippet view article find links to article
(May 2003). "Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element". Blood
IFNB1 (857 words) [view diff] exact match in snippet view article find links to article
(1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5
Poikiloderma vasculare atrophicans (1,357 words) [view diff] no match in snippet view article find links to article
can also be idiopathic. PVA may be considered a rare variant of cutaneous T-cell lymphoma, a non-Hodgkin's form of lymphoma affecting the skin. It may also
Decay-accelerating factor (962 words) [view diff] exact match in snippet view article find links to article
positive regulation of CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell cytokine production complement activation, classical
CYLD (gene) (1,547 words) [view diff] no match in snippet view article
familial cylindromatosis-type. CYLD gene mutations are also associated with T-Cell Acute Lymphoblastic Leukemia, multiple myeloma, hepatocellular carcinoma
Interferon gamma release assay (583 words) [view diff] no match in snippet view article find links to article
as positive control. A single CD4+ T-cell mega pool (CD4+ pool) consisted of 221 predicted HLA class II CD4+ T-cell epitope peptides covering the entire
Ralph M. Steinman (1,705 words) [view diff] exact match in snippet view article find links to article
that dendritic cells link innate to adaptive immunity, including adaptive T cell-mediated immunity. He studied the initiation of antibody responses in tissue
KDM5A (1,598 words) [view diff] no match in snippet view article find links to article
interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity
Chromosome 3 (1,978 words) [view diff] no match in snippet view article find links to article
similarity 19 member A4, C-C motif chemokine like TCAIM: encoding protein T-cell activation inhibitor, mitochondrial TDGF1: Teratocarcinoma-derived growth
Epstein–Barr virus latent membrane protein 1 (509 words) [view diff] exact match in snippet view article find links to article
EBV-associated B cell lymphatic cancers, and the malignant NK cells of NK/T cell lymphatic cancers. Pratt, Z; Zhang, J; Sugden, B. (2012). "The latent membrane
Tazemetostat (731 words) [view diff] no match in snippet view article find links to article
tazemetostat are at increased risk of developing secondary malignancies including: T-cell lymphoblastic lymphoma (a type of blood cancer that affects the lymphatic
Interleukin 13 (3,008 words) [view diff] exact match in snippet view article find links to article
cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. Interleukin-13 is a central
Structure and genome of HIV (3,936 words) [view diff] no match in snippet view article find links to article
agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune
Linker for activation of T cells (2,288 words) [view diff] exact match in snippet view article find links to article
known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded
Fas receptor (2,675 words) [view diff] exact match in snippet view article find links to article
(December 2020). "A critical role for fas-mediated off-target tumor killing in T cell immunotherapy". Cancer Discovery. 11 (3): 599–613. doi:10.1158/2159-8290
DUSP22 (683 words) [view diff] exact match in snippet view article find links to article
PMID 11346645. Alonso A, Merlo JJ, Na S, et al. (2002). "Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity
PDE4B (1,442 words) [view diff] exact match in snippet view article find links to article
"Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication". Proceedings of the National
PRKD2 (940 words) [view diff] no match in snippet view article find links to article
"Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation". J. Biol. Chem. 280 (14): 13762–70. doi:10.1074/jbc
GLUT1 (2,591 words) [view diff] no match in snippet view article find links to article
on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. GLUT1 accounts for 2 percent of the protein
Nuclear receptor 4A1 (2,530 words) [view diff] exact match in snippet view article find links to article
of Nuclear receptor 4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overcomes T cell tolerance and exaggerates effector function
Panobinostat (1,282 words) [view diff] exact match in snippet view article find links to article
August 2012[update], it is being tested against Hodgkin's Lymphoma, cutaneous T cell lymphoma (CTCL) and other types of malignant disease in Phase III clinical
Checkpoint inhibitor (2,093 words) [view diff] exact match in snippet view article find links to article
immune cell activity. Among PD-L1 functions is a key regulatory role on T cell activities. It appears that (cancer-mediated) upregulation of PD-L1 on the
CCL17 (3,871 words) [view diff] exact match in snippet view article find links to article
CCR4 is also expressed by T cells involved in adult T-cell leukemia/lymphoma and cutaneous T cell lymphomas, making its ligands (namely CCL17) an attractive
Ribosomal protein S6 (378 words) [view diff] exact match in snippet view article find links to article
decay protein biosynthesis G1 phase mitotic cell cycle placenta development T cell proliferation involved in immune response rRNA processing activation-induced
SEMA7A (1,457 words) [view diff] no match in snippet view article find links to article
as well as in the newborn and adult thymus, indicative of a development T-cell role. In wild type neurons, addition of Sema7A under in vitro conditions
Chromosome 7 (2,947 words) [view diff] exact match in snippet view article find links to article
encoding protein T cell receptor beta constant 1 TRBC2 encoding protein T cell receptor beta constant 2 TRGV1: encoding protein T cell receptor gamma variable
Experimental autoimmune encephalomyelitis (2,134 words) [view diff] no match in snippet view article find links to article
acute disseminated encephalomyelitis (ADEM). EAE is also the prototype for T-cell-mediated autoimmune disease in general.[citation needed] EAE development
NAGly receptor (1,148 words) [view diff] exact match in snippet view article find links to article
intraepithelial T cell differentiation negative regulation of tumor necrosis factor production CD8-positive, gamma-delta intraepithelial T cell differentiation
Drug rash with eosinophilia and systemic symptoms (4,291 words) [view diff] exact match in snippet view article find links to article
HLA-DQ, or HLA-DR proteins may bind to a T-cell receptor to stimulate the receptor-bearing parent T cell to initiate attacks on self tissues. Alternatively
Chlormethine (1,740 words) [view diff] exact match in snippet view article find links to article
administration of mechlorethamine has efficacy in mycosis fungoides-type cutaneous T cell lymphoma. Another use of chlormethine is in the synthesis of pethidine (meperidine)
TGF beta receptor 2 (960 words) [view diff] exact match in snippet view article find links to article
cell apoptotic process response to steroid hormone positive regulation of T cell tolerance induction receptor-mediated endocytosis response to organic substance
Cell culture (8,400 words) [view diff] no match in snippet view article find links to article
Mitchell LA, Décarie D, Tingle AJ, Nepom GT (March 1998). "Promiscuous T-cell recognition of a rubella capsid protein epitope restricted by DRB1*0403
Wiskott–Aldrich syndrome protein (2,588 words) [view diff] exact match in snippet view article find links to article
Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". The Journal of Experimental Medicine. 194
ADAM8 (617 words) [view diff] exact match in snippet view article find links to article
inflammatory response cellular response to hypoxia positive regulation of T cell migration positive regulation of tumor necrosis factor (ligand) superfamily
Vaccine (14,389 words) [view diff] no match in snippet view article find links to article
smallpox and polio vaccines, are able to induce killer T-cell (TC or CTL) responses, helper T-cell (TH) responses and antibody immunity. However, attenuated
IRF1 (1,861 words) [view diff] exact match in snippet view article find links to article
alpha-beta T cell proliferation CD8-positive, alpha-beta T cell differentiation regulation of innate immune response negative regulation of regulatory T cell differentiation
TXK (gene) (718 words) [view diff] no match in snippet view article
"Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function". J. Biol. Chem. 271 (33): 19641–4. doi:10.1074/jbc.271
Ephrin B1 (1,097 words) [view diff] exact match in snippet view article find links to article
Biological process positive regulation of T cell proliferation nervous system development cell-cell signaling T cell costimulation multicellular organism development
ETV6 (4,620 words) [view diff] exact match in snippet view article find links to article
frameshift mutations in the'ETV6 gene have been associated with ~12% of adult T cell Acute lymphoblastic leukemia cases. These mutations involve insertions or
VCAM-1 (774 words) [view diff] no match in snippet view article find links to article
immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The VCAM-1 gene contains six or seven immunoglobulin domains
Science and technology in Canada (1,448 words) [view diff] no match in snippet view article find links to article
discovery in genetics, which include stem cells, site-directed mutagenesis, T-cell receptor and the identification of the genes that cause Fanconi anemia,
TIM (498 words) [view diff] no match in snippet view article find links to article
also known as T-cell immunoglobulin and mucin-domain 1 (TIM-1) HAVCR2 (Hepatitis A virus cellular receptor 2), also known as T-cell immunoglobulin and
Coronary artery disease (10,706 words) [view diff] exact match in snippet view article find links to article
related directly to T cell function and the control of differentiation. Butyrophilin (BTN1A1) is a known co-regulator for T cell activation. Fibromodulin
List of MeSH codes (G05) (865 words) [view diff] no match in snippet view article
gene rearrangement, alpha-chain t-cell antigen receptor MeSH G05.330.801.211 – gene rearrangement, beta-chain t-cell antigen receptor MeSH G05.330.801
TIM (498 words) [view diff] no match in snippet view article find links to article
also known as T-cell immunoglobulin and mucin-domain 1 (TIM-1) HAVCR2 (Hepatitis A virus cellular receptor 2), also known as T-cell immunoglobulin and
Palindromic sequence (823 words) [view diff] exact match in snippet view article find links to article
is exposed to antibiotic tetracyclin, it does not survive. Diversity of T cell receptor (TCR) genes is generated by nucleotide insertions upon V(D)J recombination
Coronary artery disease (10,706 words) [view diff] exact match in snippet view article find links to article
related directly to T cell function and the control of differentiation. Butyrophilin (BTN1A1) is a known co-regulator for T cell activation. Fibromodulin
Interleukin 12 receptor, beta 1 subunit (1,291 words) [view diff] exact match in snippet view article find links to article
regulation of memory T cell differentiation cellular response to interferon-gamma signal transduction positive regulation of activated T cell proliferation positive
SIGLEC6 (2,036 words) [view diff] exact match in snippet view article find links to article
and acute myeloid leukemia cells and is being explored as a target of CAR T cell therapy. Siglec-6 was identified in a screen for leptin-binding proteins
CDC classification system for HIV infection (1,576 words) [view diff] no match in snippet view article find links to article
HIV and present with one of the following: A CD4+ T-cell count below 200 cells/μl (or a CD4+ T-cell percentage of total lymphocytes of less than 14%)
CD300A (571 words) [view diff] exact match in snippet view article find links to article
membrane ficolin-1-rich granule membrane Biological process regulation of T cell receptor signaling pathway immune system process negative regulation of
Decoy receptor 3 (1,243 words) [view diff] exact match in snippet view article find links to article
regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A
IRF1 (1,861 words) [view diff] exact match in snippet view article find links to article
alpha-beta T cell proliferation CD8-positive, alpha-beta T cell differentiation regulation of innate immune response negative regulation of regulatory T cell differentiation
SIRPG (548 words) [view diff] no match in snippet view article find links to article
antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation". Blood. 105 (6): 2421–7. doi:10.1182/blood-2004-07-2823.
MAP3K7 (1,695 words) [view diff] exact match in snippet view article find links to article
signaling pathway protein phosphorylation JNK cascade positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity
Leukapheresis (637 words) [view diff] exact match in snippet view article find links to article
its use is controversial and rare. Leukapheresis is used in evolving CAR-T cell therapy to obtain leukocytes from a cancer patient or donor which can be
List of MeSH codes (G04) (2,119 words) [view diff] no match in snippet view article
gene rearrangement, alpha-chain t-cell antigen receptor MeSH G04.610.626.325.211 – gene rearrangement, beta-chain t-cell antigen receptor MeSH G04.610.626
Transforming growth factor beta (8,680 words) [view diff] no match in snippet view article find links to article
TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell
ETS1 (1,811 words) [view diff] exact match in snippet view article find links to article
knockout mice have aberrant thymic differentiation, reduced peripheral T cell numbers, reduced IL-2 production, a skewing towards a memory/effector phenotype
Jonathan Sprent (126 words) [view diff] exact match in snippet view article find links to article
research has focused on the formation and activation of T cell leukocytes, and methods to overcome T cell-mediated rejection of transplanted tissue. 1995: J
HLA-DRB5 (1,064 words) [view diff] exact match in snippet view article find links to article
variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor". J. Immunol. 144 (9): 3341–6. doi:10.4049/jimmunol.144.9.3341
BRAF (gene) (5,404 words) [view diff] exact match in snippet view article
proliferation CD4-positive, alpha-beta T cell differentiation positive T cell selection CD4-positive or CD8-positive, alpha-beta T cell lineage commitment response
Diphtheria toxin (1,494 words) [view diff] exact match in snippet view article find links to article
agent. Resimmune is an immunotoxin that is in clinical trials in cutaneous T cell lymphoma patients. It uses diphtheria toxin (truncated by the cell binding
Enterotoxin (1,150 words) [view diff] no match in snippet view article find links to article
different binding mode(s) when it interacts with MHC class II molecules or the T-cell receptor. The beta-grasp domain has some structural similarities to the
Α-Ketoglutaric acid (1,401 words) [view diff] exact match in snippet view article find links to article
that in glutamine deprived conditions, α-ketoglutarate promotes naïve CD4+ T cell differentiation into TH1 whilst inhibiting their differentiation into anti-inflammatory
Insulin receptor (3,785 words) [view diff] exact match in snippet view article find links to article
up-regulated upon T-cell receptor (TCR) activation. Indeed, insulin has been shown when supplied exogenously to promote in vitro T cell proliferation in
Death receptor 6 (1,059 words) [view diff] exact match in snippet view article find links to article
N, Solenberg PJ, Zhang Q, Song HY, Yang DD (July 2001). "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice". Immunity
HLA-DRA (1,145 words) [view diff] exact match in snippet view article find links to article
variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor". J. Immunol. 144 (9): 3341–6. doi:10.4049/jimmunol.144.9.3341
HLA-DRB1 (666 words) [view diff] exact match in snippet view article find links to article
of T cell proliferation T-helper 1 type immune response positive regulation of insulin secretion involved in cellular response to glucose stimulus T cell
Immunotoxin (573 words) [view diff] exact match in snippet view article find links to article
treat T cell leukemias Resimmune, or A-dmDT390-bisFv(UCHT1), an experimental anti-T cell immunotoxin in clinical trials to treat cutaneous T-cell lymphoma
EGR3 (653 words) [view diff] exact match in snippet view article find links to article
system development positive regulation of T cell differentiation in thymus regulation of gamma-delta T cell differentiation positive regulation of transcription
HLA-DRB3 (1,108 words) [view diff] exact match in snippet view article find links to article
variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor". J. Immunol. 144 (9): 3341–6. doi:10.4049/jimmunol.144.9.3341
PTPN7 (1,111 words) [view diff] exact match in snippet view article find links to article
kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through
BATF (gene) (885 words) [view diff] no match in snippet view article
(May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem