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Longer titles found: Huntingtin-associated protein 1 (view), Huntingtin-interacting protein 1 (view), Huntingtin Interacting Protein (view)

searching for Huntingtin 116 found (205 total)

alternate case: huntingtin

Dimitri Krainc (1,351 words) [view diff] exact match in snippet view article find links to article

P., and Krainc, D. (2011) Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway. Nature Medicine

(AD).   Pridopidine exhibits a neuroprotective effect against mutant Huntingtin (mHTT)-induced cell death in mouse primary HD neurons and human HD iPSCs

Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol.

40-kDa huntingtin-associated protein also known as (Coagulation factor VIII associated 1) is a protein that in humans is encoded by the F8A1, F8A2, and

Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene. GRCh38: Ensembl release 89: ENSG00000130787

for cell survival. It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription

Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA (December 1997). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin"

proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess

oligomerization events and associated structures involving the protein encoded by huntingtin exon-1, which may provide a potential avenue for therapeutic intervention

Gowan K, Lee JE (August 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proceedings of the National

D'Souza-Schorey C (March 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752

associated sorting protein 2". Horn SC, Lalowski M, Goehler H, et al. (2007). "Huntingtin interacts with the receptor sorting family protein GASP2". Journal of

ankyrin-like repeat in synphilin 1 with an aggresome-targeting signal from huntingtin was sufficient for aggresome formation upon inhibition of the proteasome

Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics

and its expression is highly regulated. Examples of FICD include HYPE (Huntingtin Yeast Interacting Partner E) in humans, Fic-1 in C. elegans, and dfic

other synucleinopathies and is involved in spinal-cord injury; mutant huntingtin, which causes Huntington's disease; islet amyloid polypeptide (amylin)

family". Hattula K, Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Current Biology. 10 (24):

The A subunit, a founding member of the HEAT repeat protein family (huntingtin, EF3, PP2A, TOR1), is the scaffold required for the formation of the heterotrimeric

EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447

family member 5C". Engelender S, Sharp AH, Colomer V, et al. (1998). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin"

EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

(2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease

Hrp65-2 Hectochlorin HS1 (actin binding protein) Helicase II Hsp27 HIP1 (Huntingtin Interacting protein 1) Hsp70 Histactophilin Hsp90 Histidine rich protein

Kumar PD, Mizukami I, Smithson GM, Bradley SV, et al. (November 2001). "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

scaffold for other factors, including the chaperone like protein HYPK (Huntingtin Interacting Protein K) and Naa50, the catalytic acetyltransferase subunit

Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

MJ, et al. (2003). "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci

; Björkblom, B.; Coffey, E.; Bagnato, C.; Han, D. (2009). "Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating

(Jan 2006). "Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity"

interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity". Hum

Muchowski PJ (2003). "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

"Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently". The Journal of Biological Chemistry

(December 2015). "Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat". Brain. 138 (Pt 12): 3632–3653. doi:10

therapy updates". FierceBiotech. Retrieved July 29, 2020. "Exciting new Huntingtin lowering tool described - HDBuzz - Huntington's disease research news"

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (September 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics

depression and psychosis. The disease is caused by a mutation in the Huntingtin gene, on chromosome 4, which causes abnormally large numbers of glutamate

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10

Manajit; Hartl, F. Ulrich (2016). "Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors". Molecular Cell. 63 (6):

BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E (September 2003). "Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled

BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E (September 2003). "Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

(September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10

Lunkes, A, […], Mandel, J.-L. and Trottier Y. Proteases acting on mutant Huntingtin generate cleaved products that differentially build up cytoplasmic and

PMC 2119948. PMID 8120099. Engelender S, Sharp AH, Colomer V, et al. (1998). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin"

Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

Kurschner C, Ellerby LM, Peltier JM, Botas J, Hughes RE (May 2007). "Huntingtin interacting proteins are genetic modifiers of neurodegeneration". PLOS

shock response in cells expressing full-length polyglutamine-expanded huntingtin". PLOS ONE. 7 (5): e37929. Bibcode:2012PLoSO...737929C. doi:10.1371/journal

T, Hamby A, Massa SM (August 2005). "Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease

the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin". Experimental Cell Research. 313 (3): 538–50. doi:10.1016/j.yexcr.2006

(2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis"

Chaves, Gepoliano; Stanley, John; Pourmand, Nader (2019-08-23). "Mutant Huntingtin Affects Diabetes and Alzheimer's Markers in Human and Cell Models of Huntington's

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS (Nov 2001). "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for

transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Hum. Mol. Genet. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647. PMID 10441327

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

PMID 15741236. Ralser M, Nonhoff U, Albrecht M, et al. (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated

EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447

(Sep 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65

(Mar 2007). "Aggregate-centered redistribution of proteins by mutant huntingtin". Biochemical and Biophysical Research Communications. 354 (1): 39–44

Nicholson DW (February 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol.

S2CID 86447340. Jones AL (1999). "The localization and interactions of huntingtin". Philos. Trans. R. Soc. Lond. B Biol. Sci. 354 (1386): 1021–7. doi:10

Edwardson JM, Wang CT, Gong B, et al. (2003). "Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II". J. Biol

1007/BF03402003. PMC 2039936. PMID 11984006. Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated

NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin". Nature Medicine. 15 (12): 1407–1413. doi:10.1038/nm.2056. ISSN 1546-170X

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10

EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

PMC 2754410. PMID 19479823. Caviston JP, Holzbaur EL (April 2009). "Huntingtin protein is an essential integrator of intracellular vesicular trafficking"

"Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation". Proceedings of the National

YF (February 2002). "Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12)

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

(September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–865

interaction partners are involved in the N-terminal acetylation by NatA. Huntingtin interacting protein K (HYPK) interacts with hNatA on the ribosome to affect

(Sep 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65

NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin". Nature Medicine. 15 (12): 1407–1413. doi:10.1038/nm.2056. ISSN 1546-170X

interaction partners are involved in the N-terminal acetylation by NatA. Huntingtin interacting protein K (HYPK) interacts with hNatA on the ribosome to affect

deletion or single nucleotide insertion within the polyglutamine tract of huntingtin exon 1 would shift the CAG, polyglutamineen coding frame by +1 (+1 frame

repeats in exons or introns can cause disease. For example, the human gene huntingtin (Htt) typically contains 6–29 tandem repeats of the nucleotides CAG (encoding

et al. (May 2006). "Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1". The Journal of Biological Chemistry. 281 (20): 14474–85

et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

(September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65

transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Human Molecular Genetics. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647.

transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Human Molecular Genetics. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647.

; Zamore, P. D.; Aronin, N. (2007). "Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral

which promote ATP hydrolysis. BiP is also a validated substrate of HYPE (Huntingtin Yeast Interacting Partner E), which can adenylate BiP at multiple residues

Worley, Paul; Holzbaur, Erika L.F.; Ross, Christopher A. (1997-12-01). "Huntingtin-associated Protein 1 (HAP1) Interacts with the p150Glued Bubunit of Dynactin"

Marmorstein R (10 May 2018). "Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK". Structure. 26 (7): 925–935.e8. doi:10.1016/j

Bertolotti, Anne (2006-11-24). "Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast". The Journal of Biological

Horvath S, Loo JA, Yang XW (12 July 2012). "Network organization of the huntingtin proteomic interactome in mammalian brain". Neuron. 75 (1): 41–57. doi:10

(September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65

(RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro". The Journal of Biological Chemistry. 284 (18): 11845–53

(September 2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Molecular Cell. 15 (6): 853–65

EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10

members of the XMAP215/Dis1 family. Each domain consists of six HEAT (Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A and

"Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression". Cell. 150 (5): 895–908. doi:10.1016/j.cell.2012.08.002. PMC 3444165

in the Huntington disease gene / allele-specific silencing of mutant huntingtin". Molecular Therapy. 19 (12): 2178–85. doi:10.1038/mt.2011.201. PMC 3242664

Chighladze E, Arbez N, Boronina T, Herbrich S, Cole RN, et al. (May 2012). "Huntingtin protein interactions altered by polyglutamine expansion as determined

Marchi P, Ascardi C, Alberti L, Di Pardo A, et al. (January 2010). "Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein

demonstrate that treatment with rapamycin facilitates the clearance of huntingtin aggregates. Perhaps the same treatment may be useful in clearing Aβ deposits

PJ (December 2003). "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–1772. Bibcode:2003Sci

WJ, Olejniczak M (2018). "Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases". Frontiers in Neuroscience. 12: 75. doi:10.3389/fnins

the behaviour of disease-related proteins and peptides, such as Aβ42, huntingtin and FUS, which are involved in the onset of Alzheimer's, Huntington's

together is called the NatA complex. The NatA complex also binds to HYPK (Huntingtin-interacting protein K) which can stabilize the NatA complex. NatA targets

For instance, SQSTM1/p62, often found in Lewy bodies, tau tangles, and huntingtin aggregates, is the prototype of autophagy receptor that regulates the

Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity". Cell Reports. 27 (1): 59–70.e4. doi:10.1016/j