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searching for Alpha-synuclein 64 found (136 total)

alternate case: alpha-synuclein

Contursi Terme (978 words) [view diff] exact match in snippet view article find links to article

led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders
Virginia Man-Yee Lee (863 words) [view diff] exact match in snippet view article find links to article
tau, alpha-synuclein and TDP-43 in mechanisms that compromise neuronal viability. Major accomplishments include discovery of tau, alpha-synuclein and TDP-43
RNF19A (707 words) [view diff] exact match in snippet view article find links to article
ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript
Site-directed spin labeling (690 words) [view diff] exact match in snippet view article find links to article
fibrils and the structure of membrane bound Parkinson's disease protein alpha-synuclein. A 2012 study generated a high resolution structure of IAPP fibrils
Mir-7 microRNA precursor (1,370 words) [view diff] exact match in snippet view article find links to article
PMID 20230785. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry
Mir-153 microRNA precursor family (768 words) [view diff] exact match in snippet view article find links to article
PMID 20152932. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry
TPPP (949 words) [view diff] exact match in snippet view article find links to article
PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol
Hsp70 (4,567 words) [view diff] exact match in snippet view article find links to article
human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that
ATP13A2 (706 words) [view diff] exact match in snippet view article find links to article
caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation". Human Molecular Genetics. 23 (11): 2791–801. doi:10
KLK6 (1,244 words) [view diff] exact match in snippet view article find links to article
Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (Oct 2003). "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis
DNAJA2 (720 words) [view diff] exact match in snippet view article find links to article
genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. doi:10.1126/science.1090389. PMID 14657499
FKBP2 (838 words) [view diff] exact match in snippet view article find links to article
genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci...302.1769W. doi:10
Tauopathy (1,351 words) [view diff] exact match in snippet view article find links to article
Moussaud-Lamodière EL, Delenclos M, Ross OA, McLean PJ (October 2014). "Alpha-synuclein and tau: teammates in neurodegeneration?". Molecular Neurodegeneration
PARK7 (1,836 words) [view diff] exact match in snippet view article find links to article
2004). "DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLOS Biology. 2 (11): e362. doi:10.1371/journal
Conformational ensembles (834 words) [view diff] exact match in snippet view article find links to article
M (December 2009). "Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements". Journal
TUBA1A (1,798 words) [view diff] exact match in snippet view article find links to article
Clayton DF, George JM (November 2001). "Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells". Brain Research. Molecular
Clinical neurochemistry (2,609 words) [view diff] exact match in snippet view article find links to article
rest and bradykinesia. In some rare forms, protein aggregation of alpha-synuclein and parkin can elicit symptoms of Parkinson's disease. For a variety
Breakthrough Prize in Life Sciences (1,982 words) [view diff] exact match in snippet view article find links to article
amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson’s disease and Multiple
Proprotein convertase subtilisin/kexin type 1 inhibitor (441 words) [view diff] no match in snippet view article find links to article
to its potent ability to block the aggregation of beta amyloid and alpha synuclein in vitro, and to block oligomer cytotoxicity in cells. GRCh38: Ensembl
C7orf31 (628 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
MAP1B (1,058 words) [view diff] exact match in snippet view article find links to article
"Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200
DNAJC5 (1,876 words) [view diff] exact match in snippet view article find links to article
Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC (November 2005). "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration". Cell. 123
Eva Braak (392 words) [view diff] exact match in snippet view article find links to article
PMID 1759558. Braak, E.; Sandmann-Keil, D.; Rüb, U.; Gai WP, R.A.I (2001). "Alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower
Coproporphyrinogen III oxidase (2,030 words) [view diff] exact match in snippet view article find links to article
Melamed E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase". Journal of Molecular
GRK5 (1,986 words) [view diff] exact match in snippet view article find links to article
"Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". The Journal of Biological Chemistry. 275 (1): 390–7. doi:10.1074/jbc
C11orf52 (646 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
RPH3A (1,097 words) [view diff] exact match in snippet view article find links to article
PMID 12937130. Dalfó E, Barrachina M, Rosa JL, et al. (2004). "Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease"
2,4-dienoyl-CoA reductase 1 (536 words) [view diff] exact match in snippet view article find links to article
Murata M, Toda T (2008). "Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89–94. doi:10
Torsin A (908 words) [view diff] exact match in snippet view article find links to article
J, Ozelius LJ, et al. (2001). "A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study". Am
YWHAE (1,607 words) [view diff] case mismatch in snippet view article find links to article
Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci
C11orf53 (545 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
Tardigrade specific proteins (761 words) [view diff] exact match in snippet view article find links to article
(October 2003). "A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders". Journal
C6orf201 (859 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
MAPK8IP1 (1,323 words) [view diff] case mismatch in snippet view article find links to article
PMID 11726277. Hashimoto M, Hsu LJ, Rockenstein E, et al. (2002). "alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal
Cytochrome c oxidase subunit III (2,383 words) [view diff] exact match in snippet view article find links to article
Melamed E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase". Journal of Molecular
Bcl-2-associated death promoter (1,975 words) [view diff] case mismatch in snippet view article find links to article
Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci
Neuroprotection (3,658 words) [view diff] exact match in snippet view article find links to article
S2CID 32651665. Li W, Lee MK (June 2005). "Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3
Vesicular monoamine transporter 2 (1,864 words) [view diff] exact match in snippet view article find links to article
(2008). "Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells". Cell. Mol. Neurobiol. 28 (1): 35–47
C1orf131 (1,280 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". J. Biol. Chem. (39th ed.). 286 (39): 34088–34100. doi:10.1074/jbc
Tamir Gonen (1,094 words) [view diff] exact match in snippet view article find links to article
the first novel structure was determined by MicroED for the protein alpha-synuclein at 1.4Å resolution in collaboration with David Eisenberg and in 2016
LRRK2 (1,898 words) [view diff] exact match in snippet view article find links to article
nsons/Young-Onset-Parkinsons. Singleton AB (August 2005). "Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin"
Ana Maria Cuervo (1,069 words) [view diff] exact match in snippet view article find links to article
Lansbury, PT; Sulzer, D (27 August 2004). "Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy". Science. 305 (5688): 1292–5. doi:10
KIAA0825 (1,741 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
Mitophagy (2,662 words) [view diff] case mismatch in snippet view article find links to article
Oliveira, CR; Cardoso, SM (2011). "Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011: 693761. doi:10.4061/2011/693761
CFAP299 (1,090 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
CFAP299 (1,090 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
CLPB (2,090 words) [view diff] exact match in snippet view article find links to article
over 10-fold. Indeed, PARL-activated Skd3 is capable of disassembling alpha-synuclein fibrils in vitro. Even though the bacterial orthologue, ClpB, contributes
VDAC1 (4,089 words) [view diff] exact match in snippet view article find links to article
Kelly L, He Y, Waliczek T, Kordower JH (September 2014). "Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental
Rudolph E. Tanzi (4,977 words) [view diff] exact match in snippet view article find links to article
chaperones targeting metal-induced aggregation of beta-amyloid in AD and of alpha-synuclein and Lewy bodies in Parkinson disease (being carried out by Alterity
DMAC1 (1,559 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". J Biol Chem. 286 (39): 34088–34100. doi:10.1074/jbc.M111.243907.
Sirtuin 2 (3,647 words) [view diff] exact match in snippet view article find links to article
MB, Hyman BT, Kazantsev AG (Jul 2007). "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. 317 (5837):
Astrocyte (7,243 words) [view diff] case mismatch in snippet view article find links to article
Ingelsson M, et al. (December 2017). "Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes". The Journal of Neuroscience. 37 (49): 11835–11853
Copy number variation (5,534 words) [view diff] case mismatch in snippet view article find links to article
Johnson J, Singleton A, Hague S, Kachergus J, et al. (October 2003). "alpha-Synuclein locus triplication causes Parkinson's disease". Science. 302 (5646):
Ccdc60 (1,286 words) [view diff] exact match in snippet view article find links to article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
William Langston (2,130 words) [view diff] exact match in snippet view article find links to article
Langston JW (Feb 2004). "Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications". Ann Neurol. 55 (2): 174–9. doi:10.1002/ana
Autophagy (9,391 words) [view diff] case mismatch in snippet view article find links to article
Cardoso SM (January 2011). "Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011: 693761. doi:10.4061/2011/693761
Ubiquitin C (4,255 words) [view diff] case mismatch in snippet view article find links to article
Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E (March 2008). "alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role
BEND2 (protein) (1,803 words) [view diff] exact match in snippet view article
proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10
Nancy Bonini (2,939 words) [view diff] exact match in snippet view article find links to article
Trojanowski JQ, Lee VM, Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295(5556):865-8
Royal Medal (434 words) [view diff] exact match in snippet view article find links to article
Biology "for identifying and characterising assembled tau protein and alpha-synuclein and showing that they form the inclusions of Alzheimer’s and Parkinson’s
Protein phosphorylation (7,845 words) [view diff] exact match in snippet view article find links to article
"Parkinson's Disease | Elucidating the Role of Phosphorylation in modulating alpha-synuclein aggregation and toxicity in Parkinson's disease and related disorders"
Alzheimer's Disease Neuroimaging Initiative (4,871 words) [view diff] case mismatch in snippet view article find links to article
Ju-Hee (2016-05-01). "Cerebrospinal Fluid Amyloid β1-42, Tau, and Alpha-Synuclein Predict the Heterogeneous Progression of Cognitive Dysfunction in Parkinson's
List of women neuroscientists (6,651 words) [view diff] exact match in snippet view article find links to article
(fl. from 1980s), neuroscientist noted for identifying the protein alpha-synuclein as the major component of Lewy bodies Tara Spires-Jones (born 1976)
CSNK1D (14,714 words) [view diff] exact match in snippet view article find links to article
van Rossum M, Selenko P (December 2014). "Efficient modification of alpha-synuclein serine 129 by protein kinase CK1 requires phosphorylation of tyrosine