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searching for Alpha-synuclein 74 found (152 total)

Contursi Terme (987 words) [view diff] exact match in snippet view article find links to article

led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders

Squalamine (732 words) [view diff] exact match in snippet view article find links to article

displace alpha-synuclein from neuronal membranes both in vitro, in isolated cells, and in a C. elegans Parkinson disease model. Since alpha synuclein accumulates

RNF19A (711 words) [view diff] exact match in snippet view article find links to article

ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript

Trodusquemine (453 words) [view diff] exact match in snippet view article find links to article

and lifespan in mouse models of Alzheimer's disease; reduction in alpha-synuclein aggregation and increase in healthspan and lifespan in a C.elegans

Site-directed spin labeling (690 words) [view diff] exact match in snippet view article find links to article

fibrils and the structure of membrane bound Parkinson's disease protein alpha-synuclein. A 2012 study generated a high resolution structure of IAPP fibrils

Mir-7 microRNA precursor (1,373 words) [view diff] exact match in snippet view article find links to article

PMID 20230785. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry

I-cell (431 words) [view diff] exact match in snippet view article find links to article

magnification of the alpha synuclein intraneuronal inclusions aggregated to form Lewy bodies. Stains used: mouse monoclonal alpha-synuclein antibody; counterstained

Mir-153 microRNA precursor family (768 words) [view diff] exact match in snippet view article find links to article

PMID 20152932. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry

TPPP (962 words) [view diff] exact match in snippet view article find links to article

PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol

Hsp70 (5,631 words) [view diff] exact match in snippet view article find links to article

human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that

Patrik Brundin (1,662 words) [view diff] exact match in snippet view article find links to article

of alpha-synuclein aggregates between neurons and developed corresponding animal models. This work contributed to the recognition of alpha-synuclein as

ATP13A2 (712 words) [view diff] exact match in snippet view article find links to article

caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation". Human Molecular Genetics. 23 (11): 2791–801. doi:10

FKBP2 (838 words) [view diff] exact match in snippet view article find links to article

genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci...302.1769W. doi:10

DNAJA2 (747 words) [view diff] exact match in snippet view article find links to article

genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci...302.1769W. doi:10

DJ-1 (1,884 words) [view diff] exact match in snippet view article find links to article

2004). "DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLOS Biology. 2 (11): e362. doi:10.1371/journal

Conformational ensembles (837 words) [view diff] exact match in snippet view article find links to article

M (December 2009). "Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements". Journal

Clinical neurochemistry (2,611 words) [view diff] exact match in snippet view article find links to article

rest and bradykinesia. In some rare forms, protein aggregation of alpha-synuclein and parkin can elicit symptoms of Parkinson's disease. For a variety

Tamir Gonen (1,133 words) [view diff] exact match in snippet view article find links to article

the first novel structure was determined by MicroED for the protein alpha-synuclein at 1.4Å resolution in collaboration with David Eisenberg and in 2016

Minzasolmin (154 words) [view diff] exact match in snippet view article find links to article

Martin; Biere, Anja-Leona (17 July 2023). "In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's

Tubulin alpha-1A chain (1,773 words) [view diff] exact match in snippet view article find links to article

Clayton DF, George JM (November 2001). "Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells". Brain Research. Molecular

Protein phosphorylation (7,955 words) [view diff] case mismatch in snippet view article find links to article

MG; Crowther, RA; Jakes, R; Hasegawa, M; Goedert, M (26 May 1998). "alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and

Coproporphyrinogen III oxidase (2,088 words) [view diff] exact match in snippet view article find links to article

Melamed E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase". Journal of Molecular

MAP1B (1,060 words) [view diff] exact match in snippet view article find links to article

"Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200

DNAJC5 (1,887 words) [view diff] exact match in snippet view article find links to article

Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC (November 2005). "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration". Cell. 123

C7orf31 (631 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

RPH3A (1,097 words) [view diff] exact match in snippet view article find links to article

PMID 12937130. Dalfó E, Barrachina M, Rosa JL, et al. (2004). "Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease"

2,4-dienoyl-CoA reductase 1 (536 words) [view diff] exact match in snippet view article find links to article

Murata M, Toda T (2008). "Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89–94. doi:10

C11orf52 (652 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

YWHAE (1,633 words) [view diff] case mismatch in snippet view article find links to article

Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci

GRK5 (1,986 words) [view diff] exact match in snippet view article find links to article

"Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". The Journal of Biological Chemistry. 275 (1): 390–7. doi:10.1074/jbc

Eva Braak (396 words) [view diff] exact match in snippet view article find links to article

PMID 1759558. Braak, E.; Sandmann-Keil, D.; Rüb, U.; Gai WP, R.A.I (2001). "Alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower

Torsin A (910 words) [view diff] exact match in snippet view article find links to article

J, Ozelius LJ, et al. (2001). "A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study". Am

C11orf53 (473 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–34100. doi:10

Breakthrough Prize in Life Sciences (351 words) [view diff] exact match in snippet view article find links to article

amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson's disease and Multiple

Dimitri Krainc (1,333 words) [view diff] exact match in snippet view article find links to article

G.A. and Krainc, D. (2011) Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell, 146(1):37-52

C6orf201 (887 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

MAPK8IP1 (1,424 words) [view diff] case mismatch in snippet view article find links to article

Hsu LJ, Rockenstein E, Takenouchi T, Mallory M, Masliah E (2002). "alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal

Amyloid plaques (3,370 words) [view diff] exact match in snippet view article find links to article

Checler F (September 2002). "Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's

Proprotein convertase subtilisin/kexin type 1 inhibitor (582 words) [view diff] no match in snippet view article find links to article

to its potent ability to block the aggregation of beta amyloid and alpha synuclein in vitro, and to block oligomer cytotoxicity in cells. Recent data

Vesicular monoamine transporter 2 (2,015 words) [view diff] exact match in snippet view article find links to article

(2008). "Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells". Cell. Mol. Neurobiol. 28 (1): 35–47

Cytochrome c oxidase subunit III (2,391 words) [view diff] exact match in snippet view article find links to article

Melamed E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase". Journal of Molecular

Neuroprotection (3,640 words) [view diff] exact match in snippet view article find links to article

S2CID 32651665. Li W, Lee MK (June 2005). "Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3

Bcl-2-associated death promoter (1,980 words) [view diff] case mismatch in snippet view article find links to article

Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci

Ana Maria Cuervo (1,113 words) [view diff] exact match in snippet view article find links to article

Lansbury, PT; Sulzer, D (27 August 2004). "Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy". Science. 305 (5688): 1292–5. Bibcode:2004Sci

Dopamine receptor D3 (3,175 words) [view diff] exact match in snippet view article find links to article

although some variants may be subject to nonsense-mediated decay (NMD). Alpha-synuclein (α-Syn) aggregation via Lewy bodies inclusion, a pathogenic signature

LRRK2 (1,929 words) [view diff] exact match in snippet view article find links to article

nsons/Young-Onset-Parkinsons. Singleton AB (August 2005). "Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin"

C1orf131 (1,307 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". J. Biol. Chem. 286 (39) (39th ed.): 34088–34100. doi:10.1074/jbc

Tardigrade specific proteins (1,649 words) [view diff] exact match in snippet view article find links to article

(October 2003). "A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders". Journal

VDAC1 (4,079 words) [view diff] exact match in snippet view article find links to article

Kelly L, He Y, Waliczek T, Kordower JH (September 2014). "Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental

Cardiolipin (3,849 words) [view diff] exact match in snippet view article find links to article

abnormality and electron transport chain impairment in mice lacking alpha-synuclein". Molecular and Cellular Biology. 25 (22): 10190–10201. doi:10.1128/MCB

DMAC1 (1,592 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". J Biol Chem. 286 (39): 34088–34100. doi:10.1074/jbc.M111.243907.

KIAA0825 (1,749 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

CFAP299 (1,107 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

Parkinson's Foundation (3,078 words) [view diff] exact match in snippet view article find links to article

Parkinson's Foundation found evidence that Parkinson's requires the alpha-synuclein protein, a now well-known hallmark of the disease. In 2011, the Parkinson's

Sirtuin 2 (3,418 words) [view diff] exact match in snippet view article find links to article

MB, Hyman BT, Kazantsev AG (Jul 2007). "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. 317 (5837):

Pituitary pars intermedia dysfunction (2,770 words) [view diff] exact match in snippet view article find links to article

Donaldson MT, Miller L, Cribb AE (February 2005). "Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine

CLPB (2,098 words) [view diff] exact match in snippet view article find links to article

over 10-fold. Indeed, PARL-activated Skd3 is capable of disassembling alpha-synuclein fibrils in vitro. Even though the bacterial orthologue, ClpB, contributes

Ujjwal Maulik (1,910 words) [view diff] case mismatch in snippet view article find links to article

S.; Dey, A.; Maulik, U. (11 August 2021). "Studying the Effect of Alpha-Synuclein and Parkinson's Disease Linked Mutants on Inter Pathway Connectivity's"

William Langston (2,136 words) [view diff] exact match in snippet view article find links to article

Langston JW (Feb 2004). "Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications". Ann Neurol. 55 (2): 174–9. doi:10.1002/ana

FICD (2,276 words) [view diff] case mismatch in snippet view article find links to article

Montenegro, Paola; Cannon, Jason; Rochet, Jean-Christophe (2019-05-31). "Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications

Mitophagy (4,131 words) [view diff] case mismatch in snippet view article find links to article

Oliveira, CR; Cardoso, SM (2011). "Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011: 693761. doi:10.4061/2011/693761

Copy number variation (5,557 words) [view diff] case mismatch in snippet view article find links to article

Johnson J, Singleton A, Hague S, Kachergus J, et al. (October 2003). "alpha-Synuclein locus triplication causes Parkinson's disease". Science. 302 (5646):

Ccdc60 (1,286 words) [view diff] exact match in snippet view article find links to article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

BEND2 (protein) (1,795 words) [view diff] exact match in snippet view article

proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10

Astrocyte (9,291 words) [view diff] case mismatch in snippet view article find links to article

Ingelsson M, et al. (December 2017). "Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes". The Journal of Neuroscience. 37 (49): 11835–11853

Natural killer cell (9,180 words) [view diff] exact match in snippet view article find links to article

disease, levels of Natural killer cells are elevated as they degrade alpha-synuclein aggregates, destroy senescent neurons, and attenuate the neuroinflammation

Ubiquitin C (4,261 words) [view diff] case mismatch in snippet view article find links to article

Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E (March 2008). "alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role

Royal Medal (457 words) [view diff] exact match in snippet view article find links to article

Biology "for identifying and characterising assembled tau protein and alpha-synuclein and showing that they form the inclusions of Alzheimer's and Parkinson's

Nancy Bonini (2,940 words) [view diff] exact match in snippet view article find links to article

Trojanowski JQ, Lee VM, Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295(5556):865-8

Rudolph E. Tanzi (4,371 words) [view diff] exact match in snippet view article find links to article

chaperones targeting metal-induced aggregation of beta-amyloid in AD and of alpha-synuclein and Lewy bodies in Parkinson's disease. In 2000, Tanzi and Steven Wagner

Alzheimer's Disease Neuroimaging Initiative (4,886 words) [view diff] case mismatch in snippet view article find links to article

Ju-Hee (2016-05-01). "Cerebrospinal Fluid Amyloid β1-42, Tau, and Alpha-Synuclein Predict the Heterogeneous Progression of Cognitive Dysfunction in Parkinson's

David F. Clayton (1,835 words) [view diff] exact match in snippet view article find links to article

neural circuit for song production learning, one of which encodes the alpha-synuclein protein, a key player in Parkinson's and other neurodegenerative diseases

List of women neuroscientists (8,913 words) [view diff] exact match in snippet view article find links to article

(fl. from 1980s), neuroscientist noted for identifying the protein alpha-synuclein as the major component of Lewy bodies Tara Spires-Jones (born 1976)

CSNK1D (14,738 words) [view diff] exact match in snippet view article find links to article

van Rossum M, Selenko P (December 2014). "Efficient modification of alpha-synuclein serine 129 by protein kinase CK1 requires phosphorylation of tyrosine