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searching for Mitophagy 56 found (98 total)

alternate case: mitophagy

Whi2 (631 words) [view diff] exact match in snippet view article find links to article

nutrient availability on to stress responsive elements and autophagy/mitophagy mechanisms. It is encoded by a 1.46 kbp gene located on chromosome 15

Richard Youle (614 words) [view diff] exact match in snippet view article find links to article

destruction. He also investigated molecular mechanisms of autophagy and mitophagy. He received the NIH Director’s Award in 1992, 2011, and 2015. For 2021

HDAC6 (1,738 words) [view diff] exact match in snippet view article find links to article

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization positive regulation of mitophagy in response to mitochondrial depolarization

Mitochondrial permeability transition pore (3,448 words) [view diff] exact match in snippet view article find links to article

causing ROS-producing mitochondria to undergo selective lysosome-dependent mitophagy during nutrient starvation conditions. Under severe stress/pathologic

Ivan R. Nabi (708 words) [view diff] exact match in snippet view article find links to article

His recent work has identified a role for Gp78 in regulation of basal mitophagy, production of reactive oxygen species and a distinct class of ribosome-studded

Warburg hypothesis (731 words) [view diff] exact match in snippet view article find links to article

123.3191.309. PMID 13298683. Mahla, RS; et al. (2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial

UBXD8 (1,130 words) [view diff] exact match in snippet view article find links to article

the pro-survival protein Mcl1 and excessively stimulates the process of mitophagy. To better understand how lipo-toxicity is caused by saturated fatty acids

Basic helix-loop-helix ARNT-like protein 1 (5,804 words) [view diff] exact match in snippet view article find links to article

and disorganized myofilaments. In addition, mitochondrial fission and mitophagy were suppressed in BMAL1 deficient hESC-cardiomyocytes, which resulted

TSC2 (1,786 words) [view diff] exact match in snippet view article find links to article

positive regulation of macroautophagy anoikis negative regulation of mitophagy negative regulation of TOR signaling protein kinase B signaling Sources:Amigo

Farnesoid X receptor (1,945 words) [view diff] exact match in snippet view article find links to article

drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9

BNIP3 (2,672 words) [view diff] exact match in snippet view article find links to article

PA (July 2009). "Role of BNIP3 and NIX in cell death, autophagy, and mitophagy". Cell Death and Differentiation. 16 (7): 939–46. doi:10.1038/cdd.2009

ATG8 (2,085 words) [view diff] exact match in snippet view article find links to article

phosphorylated by protein kinase A to suppress participation in autophagy/mitophagy. Other homologues are the transport factor GATE-16 (Golgi-associated ATPase

VDAC3 (2,560 words) [view diff] exact match in snippet view article find links to article

observed to target Parkin to defective mitochondria to eliminate them by mitophagy. Failure to eliminate these mitochondria result in the accumulation of

Pacer (protein) (610 words) [view diff] exact match in snippet view article

phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy". The Journal of Cell Biology. 223 (7). doi:10.1083/jcb.202309015. PMC 11090050

Neuroscience Research Australia (1,733 words) [view diff] exact match in snippet view article find links to article

disease. She tested the hypothesis that the Nix protein can rejuvenate mitophagy and mitochondrial function in individuals affected by Parkinson's. NeuRA

RNF41 (647 words) [view diff] exact match in snippet view article find links to article

proliferation protein autoubiquitination apoptotic process negative regulation of mitophagy positive regulation of protein catabolic process Sources:Amigo / QuickGO

CLEC16A (1,269 words) [view diff] exact match in snippet view article find links to article

ubiquitin-dependent protein catabolic process negative regulation of mitophagy cellular response to starvation negative regulation of autophagosome maturation

HSPA1B (1,999 words) [view diff] exact match in snippet view article find links to article

"High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy". Nature. 504 (7479): 291–295. Bibcode:2013Natur.504..291H. doi:10.1038/nature12748

Optineurin (1,202 words) [view diff] exact match in snippet view article find links to article

Golgi to plasma membrane protein transport parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization positive regulation of xenophagy

HSPA1L (2,317 words) [view diff] exact match in snippet view article find links to article

"High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy". Nature. 504 (7479): 291–5. Bibcode:2013Natur.504..291H. doi:10.1038/nature12748

Transcription factor Sp1 (3,440 words) [view diff] exact match in snippet view article find links to article

Lemasters JJ, Nishina S, et al. (November 2020). "Iron loss triggers mitophagy through induction of mitochondrial ferritin". EMBO Reports. 21 (11): e50202

CD38 (3,825 words) [view diff] exact match in snippet view article find links to article

cell response against viral infection in lupus patients by suppressing mitophagy". Science Advances. 8 (24): eabo4271. Bibcode:2022SciA....8O4271C. doi:10

CD38 (3,825 words) [view diff] exact match in snippet view article find links to article

cell response against viral infection in lupus patients by suppressing mitophagy". Science Advances. 8 (24): eabo4271. Bibcode:2022SciA....8O4271C. doi:10

Tomatidine (537 words) [view diff] exact match in snippet view article find links to article

2017). "Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway". Scientific Reports. 7: 46208. Bibcode:2017NatSR

Sequestosome 1 (1,644 words) [view diff] exact match in snippet view article find links to article

regulation of transcription by RNA polymerase II protein phosphorylation mitophagy response to mitochondrial depolarisation macroautophagy endosome organization

Autophagy-related protein 13 (840 words) [view diff] exact match in snippet view article find links to article

autophagosome assembly positive regulation of protein targeting to mitochondrion mitophagy response to mitochondrial depolarisation regulation of macroautophagy

LRRK2 (2,253 words) [view diff] exact match in snippet view article find links to article

imbalance, leading to excess mitochondrial clearance from dendrites by mitophagy. LRRK2 is also a substrate for chaperone-mediated autophagy. Disease-associated

FBXO7 (1,464 words) [view diff] exact match in snippet view article find links to article

Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy". Nature Neuroscience. 16 (9): 1257–65. doi:10.1038/nn.3489. PMC 3827746

Supercomplex (1,566 words) [view diff] exact match in snippet view article find links to article

(2009). "Coenzyme Q deficiency triggers mitochondria degradation by mitophagy". Autophagy. 5 (1): 19–33. doi:10.4161/auto.5.1.7174. hdl:10261/40287

CDC37 (1,482 words) [view diff] exact match in snippet view article find links to article

of interferon-gamma-mediated signaling pathway positive regulation of mitophagy in response to mitochondrial depolarization regulation of protein kinase

SMURF1 (1,916 words) [view diff] exact match in snippet view article find links to article

pathway, planar cell polarity pathway parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization substrate localization to

Adult development (14,531 words) [view diff] exact match in snippet view article find links to article

but similar to the first, the third article explores the process of mitophagy - removal of damaged mitochondria - and how it may inhibit the progression

Serine protease HTRA2, mitochondrial (1,928 words) [view diff] exact match in snippet view article find links to article

organization cellular response to oxidative stress negative regulation of mitophagy in response to mitochondrial depolarization positive regulation of cysteine-type

Carolyn Sue (1,024 words) [view diff] exact match in snippet view article find links to article

Investigating the Nix pathway as an alternative approach to activating mitophagy in neurons, to improve the maintenance of healthy mitochondrial populations

Acyl-CoA:lysocardiolipin acyltransferase-1 (946 words) [view diff] exact match in snippet view article find links to article

mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy". Mol. Cell. Biol. 32 (21): 4493–4504. doi:10.1128/MCB.01092-12. PMC 3486149

Macrophage (10,342 words) [view diff] exact match in snippet view article find links to article

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial

Pseudomonas aeruginosa (10,005 words) [view diff] exact match in snippet view article find links to article

014. PMID 30459101. Kirienko NV, Ausubel FM, Ruvkun G (February 2015). "Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa"

ATM serine/threonine kinase (5,684 words) [view diff] exact match in snippet view article find links to article

mitochondrial homeostasis, as a regulator of mitochondrial autophagy (mitophagy) whereby old, dysfunctional mitochondria are removed. Increased ATM activity

Wolfram syndrome (5,032 words) [view diff] exact match in snippet view article find links to article

WFS2. In some cases, mutation of the gene can lead to premature aging, mitophagy and mitochondrial dysfunction. In studies using mice, WFS2 caused a decrease

Judith Klein-Seetharaman (448 words) [view diff] exact match in snippet view article find links to article

to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells". Nature Cell Biology. 15 (10): 1197–205. doi:10.1038/NCB2837

Complications of diabetes (7,353 words) [view diff] exact match in snippet view article find links to article

CNN. 2011-09-19. Kobayashi S, Liang Q (February 2015). "Autophagy and mitophagy in diabetic cardiomyopathy". Biochimica et Biophysica Acta (BBA) - Molecular

Sonodynamic therapy (9,348 words) [view diff] exact match in snippet view article find links to article

effects to treat glioblastoma. Apoptosis was successfully induced and mitophagy was inhibited in glioma cells. This is an example of how SDT can be used

P53 (13,339 words) [view diff] exact match in snippet view article find links to article

process necroptosis cellular response to UV-C negative regulation of mitophagy regulation of mitochondrial membrane permeability involved in apoptotic

TP53-inducible glycolysis and apoptosis regulator (3,453 words) [view diff] exact match in snippet view article find links to article

fructose 1,6-bisphosphate metabolic process autophagy negative regulation of mitophagy cellular response to cobalt ion response to ischemia fructose 2,6-bisphosphate

List of immune cells (789 words) [view diff] exact match in snippet view article find links to article

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial

Cancer stem cell (10,356 words) [view diff] exact match in snippet view article find links to article

Łos MJ (September 2013). "Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer

Sankar Ghosh (2,448 words) [view diff] exact match in snippet view article find links to article

(2018) An essential role for ECSIT in mitochondrial complex I assembly and mitophagy in macrophages. Cell Rep. 22:2654-2666. Oh, H., Grinberg-Bleyer, Y., Liao

MROH9 (2,166 words) [view diff] exact match in snippet view article find links to article

inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy". Acta Pharmaceutica Sinica B. 12 (2): 838–852. doi:10.1016/j.apsb.2021

Pyoverdine (4,008 words) [view diff] exact match in snippet view article find links to article

Kirienko, Natalia V.; Ausubel, Frederick M.; Ruvkun, Gary (2015-02-10). "Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa"

Timeline of aging research (18,823 words) [view diff] exact match in snippet view article find links to article

Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage". Nutrients. 14 (5): 1114. doi:10

Seamus Martin (biochemist) (1,192 words) [view diff] exact match in snippet view article

in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy. Molecular Cell 55:451-66. Henry CM and Martin SJ (2017) Caspase-8 Acts

Atg8ylation (1,693 words) [view diff] exact match in snippet view article find links to article

autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation". The Journal of Cell Biology. 215 (6): 857–874. doi:10

Patrick Purdon (2,354 words) [view diff] exact match in snippet view article find links to article

Richard J (ed.). "Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila". eLife. 7: e35878. doi:10.7554/eLife.35878. PMC 6008047

TMEM39B (2,517 words) [view diff] exact match in snippet view article find links to article

capsid/autophagosome colocalization, survival of virus-infected cells, and mitophagy in HeLa cells infected with Sindbis virus. This may suggest that TMEM39B

Pparg coactivator 1 alpha (3,863 words) [view diff] exact match in snippet view article find links to article

DA (2015). "Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle". American Journal of Physiology. 308 (9): C710-719

January–March 2022 in science (14,793 words) [view diff] exact match in snippet view article find links to article

Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage". Nutrients. 14 (5): 1114. doi:10