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searching for Mitophagy 48 found (89 total)

alternate case: mitophagy

Whi2 (631 words) [view diff] exact match in snippet view article find links to article

nutrient availability on to stress responsive elements and autophagy/mitophagy mechanisms. It is encoded by a 1.46 kbp gene located on chromosome 15

Richard Youle (614 words) [view diff] exact match in snippet view article find links to article

destruction. He also investigated molecular mechanisms of autophagy and mitophagy. He received the NIH Director’s Award in 1992, 2011, and 2015. For 2021

HDAC6 (1,738 words) [view diff] exact match in snippet view article find links to article

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization positive regulation of mitophagy in response to mitochondrial depolarization

Mitochondrial permeability transition pore (3,440 words) [view diff] exact match in snippet view article find links to article

causing ROS-producing mitochondria to undergo selective lysosome-dependent mitophagy during nutrient starvation conditions. Under severe stress/pathologic

TSC2 (1,843 words) [view diff] exact match in snippet view article find links to article

positive regulation of macroautophagy anoikis negative regulation of mitophagy negative regulation of TOR signaling protein kinase B signaling Sources:Amigo

UBXD8 (1,130 words) [view diff] exact match in snippet view article find links to article

the pro-survival protein Mcl1 and excessively stimulates the process of mitophagy. To better understand how lipo-toxicity is caused by saturated fatty acids

ATG8 (2,085 words) [view diff] exact match in snippet view article find links to article

phosphorylated by protein kinase A to suppress participation in autophagy/mitophagy. Other homologues are the transport factor GATE-16 (Golgi-associated ATPase

Basic helix-loop-helix ARNT-like protein 1 (5,635 words) [view diff] exact match in snippet view article find links to article

and disorganized myofilaments. In addition, mitochondrial fission and mitophagy were suppressed in BMAL1 deficient hESC-cardiomyocytes, which resulted

Farnesoid X receptor (1,979 words) [view diff] exact match in snippet view article find links to article

drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00524-9

BNIP3 (2,672 words) [view diff] exact match in snippet view article find links to article

PA (July 2009). "Role of BNIP3 and NIX in cell death, autophagy, and mitophagy". Cell Death and Differentiation. 16 (7): 939–46. doi:10.1038/cdd.2009

VDAC3 (2,552 words) [view diff] exact match in snippet view article find links to article

observed to target Parkin to defective mitochondria to eliminate them by mitophagy. Failure to eliminate these mitochondria result in the accumulation of

Warburg hypothesis (1,402 words) [view diff] exact match in snippet view article find links to article

PMC 4303887. PMID 25621294. Mahla, RS; et al. (2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial

RNF41 (647 words) [view diff] exact match in snippet view article find links to article

proliferation protein autoubiquitination apoptotic process negative regulation of mitophagy positive regulation of protein catabolic process Sources:Amigo / QuickGO

HSPA1B (1,959 words) [view diff] exact match in snippet view article find links to article

"High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy". Nature. 504 (7479): 291–295. Bibcode:2013Natur.504..291H. doi:10.1038/nature12748

CD38 (3,825 words) [view diff] exact match in snippet view article find links to article

cell response against viral infection in lupus patients by suppressing mitophagy". Science Advances. 8 (24): eabo4271. Bibcode:2022SciA....8O4271C. doi:10

Optineurin (1,202 words) [view diff] exact match in snippet view article find links to article

Golgi to plasma membrane protein transport parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization positive regulation of xenophagy

BECN1 (1,482 words) [view diff] exact match in snippet view article find links to article

positive regulation of autophagosome assembly autophagy of mitochondrion mitophagy autophagy positive regulation of autophagy response to mitochondrial depolarisation

HSPA1L (2,317 words) [view diff] exact match in snippet view article find links to article

"High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy". Nature. 504 (7479): 291–5. Bibcode:2013Natur.504..291H. doi:10.1038/nature12748

LRRK2 (1,929 words) [view diff] exact match in snippet view article find links to article

imbalance, leading to excess mitochondrial clearance from dendrites by mitophagy. LRRK2 is also a substrate for chaperone-mediated autophagy. Mutations

Transcription factor Sp1 (3,446 words) [view diff] exact match in snippet view article find links to article

Lemasters JJ, Nishina S, et al. (November 2020). "Iron loss triggers mitophagy through induction of mitochondrial ferritin". EMBO Reports. 21 (11): e50202

Sequestosome 1 (1,644 words) [view diff] exact match in snippet view article find links to article

regulation of transcription by RNA polymerase II protein phosphorylation mitophagy response to mitochondrial depolarisation macroautophagy endosome organization

Autophagy-related protein 13 (840 words) [view diff] exact match in snippet view article find links to article

autophagosome assembly positive regulation of protein targeting to mitochondrion mitophagy response to mitochondrial depolarisation regulation of macroautophagy

CLEC16A (1,635 words) [view diff] exact match in snippet view article find links to article

ubiquitin-dependent protein catabolic process negative regulation of mitophagy cellular response to starvation negative regulation of autophagosome maturation

FBXO7 (1,464 words) [view diff] exact match in snippet view article find links to article

Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy". Nature Neuroscience. 16 (9): 1257–65. doi:10.1038/nn.3489. PMC 3827746

Acyl-CoA:lysocardiolipin acyltransferase-1 (946 words) [view diff] exact match in snippet view article find links to article

mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy". Mol. Cell. Biol. 32 (21): 4493–4504. doi:10.1128/MCB.01092-12. PMC 3486149

Supercomplex (1,566 words) [view diff] exact match in snippet view article find links to article

(2009). "Coenzyme Q deficiency triggers mitochondria degradation by mitophagy". Autophagy. 5 (1): 19–33. doi:10.4161/auto.5.1.7174. hdl:10261/40287

CDC37 (1,482 words) [view diff] exact match in snippet view article find links to article

of interferon-gamma-mediated signaling pathway positive regulation of mitophagy in response to mitochondrial depolarization regulation of protein kinase

SMURF1 (1,916 words) [view diff] exact match in snippet view article find links to article

pathway, planar cell polarity pathway parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization substrate localization to

PPARGC1A (3,322 words) [view diff] exact match in snippet view article find links to article

DA (2015). "Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle". American Journal of Physiology. 308 (9): C710-719

Serine protease HTRA2, mitochondrial (1,928 words) [view diff] exact match in snippet view article find links to article

organization cellular response to oxidative stress negative regulation of mitophagy in response to mitochondrial depolarization positive regulation of cysteine-type

ATM serine/threonine kinase (5,639 words) [view diff] exact match in snippet view article find links to article

mitochondrial homeostasis, as a regulator of mitochondrial autophagy (mitophagy) whereby old, dysfunctional mitochondria are removed. Increased ATM activity

Carolyn Sue (944 words) [view diff] exact match in snippet view article find links to article

Investigating the Nix pathway as an alternative approach to activating mitophagy in neurons, to improve the maintenance of healthy mitochondrial populations

Pseudomonas aeruginosa (9,927 words) [view diff] exact match in snippet view article find links to article

014. PMID 30459101. Kirienko NV, Ausubel FM, Ruvkun G (February 2015). "Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa"

Macrophage (10,188 words) [view diff] exact match in snippet view article find links to article

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial

Sonodynamic therapy (9,332 words) [view diff] exact match in snippet view article find links to article

effects to treat glioblastoma. Apoptosis was successfully induced and mitophagy was inhibited in glioma cells. This is an example of how SDT can be used

Judith Klein-Seetharaman (448 words) [view diff] exact match in snippet view article find links to article

to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells". Nature Cell Biology. 15 (10): 1197–205. doi:10.1038/NCB2837

P53 (13,103 words) [view diff] exact match in snippet view article find links to article

process necroptosis cellular response to UV-C negative regulation of mitophagy regulation of mitochondrial membrane permeability involved in apoptotic

Complications of diabetes (6,936 words) [view diff] exact match in snippet view article find links to article

CNN. 2011-09-19. Kobayashi S, Liang Q (February 2015). "Autophagy and mitophagy in diabetic cardiomyopathy". Biochimica et Biophysica Acta (BBA) - Molecular

TP53-inducible glycolysis and apoptosis regulator (3,425 words) [view diff] exact match in snippet view article find links to article

fructose 1,6-bisphosphate metabolic process autophagy negative regulation of mitophagy cellular response to cobalt ion response to ischemia fructose 2,6-bisphosphate

Sankar Ghosh (2,448 words) [view diff] exact match in snippet view article find links to article

(2018) An essential role for ECSIT in mitochondrial complex I assembly and mitophagy in macrophages. Cell Rep. 22:2654-2666. Oh, H., Grinberg-Bleyer, Y., Liao

List of immune cells (786 words) [view diff] exact match in snippet view article find links to article

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial

Cancer stem cell (10,288 words) [view diff] exact match in snippet view article find links to article

Łos MJ (September 2013). "Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer

Pyoverdine (3,953 words) [view diff] exact match in snippet view article find links to article

Kirienko, Natalia V.; Ausubel, Frederick M.; Ruvkun, Gary (2015-02-10). "Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa"

MROH9 (2,277 words) [view diff] exact match in snippet view article find links to article

inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy". Acta Pharmaceutica Sinica B. 12 (2): 838–852. doi:10.1016/j.apsb.2021

Timeline of aging research (17,253 words) [view diff] exact match in snippet view article find links to article

Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage". Nutrients. 14 (5): 1114. doi:10

Patrick Purdon (2,289 words) [view diff] exact match in snippet view article find links to article

Richard J (ed.). "Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila". eLife. 7: e35878. doi:10.7554/eLife.35878. PMC 6008047

TMEM39B (2,517 words) [view diff] exact match in snippet view article find links to article

capsid/autophagosome colocalization, survival of virus-infected cells, and mitophagy in HeLa cells infected with Sindbis virus. This may suggest that TMEM39B

January–March 2022 in science (14,769 words) [view diff] exact match in snippet view article find links to article

Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage". Nutrients. 14 (5): 1114. doi:10