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searching for Amyloid plaques 79 found (141 total)

Florbetaben (18F) (1,509 words) [view diff] exact match in snippet view article

radiotracer developed for routine clinical application to visualize β-amyloid plaques in the brain. It is a fluorine-18 (18F)-labeled stilbene derivative

Avid Radiopharmaceuticals (1,244 words) [view diff] exact match in snippet view article find links to article

tracer called florbetapir (18F). Florbetapir can be used to detect beta amyloid plaques in patients with memory problems using positron emission tomography

Brain positron emission tomography (1,867 words) [view diff] exact match in snippet view article find links to article

Pittsburgh. These amyloid imaging probes permit the visualization of amyloid plaques in the brains of Alzheimer's patients and could assist clinicians in

Henry Engler (164 words) [view diff] exact match in snippet view article find links to article

Alzheimer's patients the substance PIB (Pittsburgh compound B) to detect amyloid plaques in the brain. The results were presented at the World Alzheimer's Conference

Pittsburgh compound B (1,076 words) [view diff] exact match in snippet view article find links to article

which can be used in positron emission tomography scans to image beta-amyloid plaques in neuronal tissue. Due to this property, Pittsburgh compound B may

TMEM59 (787 words) [view diff] exact match in snippet view article find links to article

therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease. Moreover, TMEM59 has been shown to potentiate

TB006 (142 words) [view diff] exact match in snippet view article find links to article

galectin-3, which is suspected to be a factor in the formation of amyloid plaques. Cummings, Jeffrey L.; Osse, Amanda M. Leisgang; Kinney, Jefferson

P3 peptide (1,340 words) [view diff] exact match in snippet view article find links to article

diffuse plaques observed in Alzheimer's disease (AD) brains and pre-amyloid plaques in people affected by Down syndrome. However, p3 peptide's role in

Swedish mutation (560 words) [view diff] exact match in snippet view article find links to article

with the Swedish mutation. As a consequence, the mice can develop amyloid plaques at around 13 months old. It is thought that the Swedish mutation causes

Lixisenatide (1,930 words) [view diff] exact match in snippet view article find links to article

lixisenatide (1 or 10 nmol/kg) or saline of APP/PS1 mice at an age when amyloid plaques had already formed. When analyzing synaptic plasticity in the hippocampus

Rudolph E. Tanzi (4,371 words) [view diff] exact match in snippet view article find links to article

reverse the Abeta42:Abeta40 ratio and thereby prevent the “seeding” of amyloid plaques. Notably, they do not inhibit gamma-secretase. Tanzi and Wagner have

Brain mitochondrial carrier protein 1 (1,733 words) [view diff] exact match in snippet view article find links to article

pro-inflammatory protein known as Glia maturation factor has been found close to amyloid plaques and neurofibrillary tangles in Alzheimer's. It is linked to the expression

TSQ (147 words) [view diff] exact match in snippet view article find links to article

Jensen M S; Silva D S; et al. (2000). "Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains"

Flutemetamol (18F) (509 words) [view diff] exact match in snippet view article

After the substance is given intravenously, it accumulates in beta amyloid plaques in the patient's brain, which thus become visible via positron emission

Geriatric psychiatry (981 words) [view diff] exact match in snippet view article find links to article

Alzheimer, a German psychiatrist and neuropathologist who first identified amyloid plaques and neurofibrillary tangles in a fifty-year-old woman he called Auguste

Alzheimer's research in Australia (269 words) [view diff] exact match in snippet view article find links to article

ultrasound waves activate microglial cells that digest and remove the amyloid plaques. "Who are we". Dementia Australia Research Foundation. Dementia Australia

Β-Methylamino-L-alanine (2,719 words) [view diff] exact match in snippet view article find links to article

co-administered BMAA with serine were found to have 70% less beta-amyloid plaques and neurofibrillary tangles than those administered BMAA alone, suggesting

Zinc transporter 1 (725 words) [view diff] exact match in snippet view article find links to article

M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10

2-Hydroxy-5-methoxybenzaldehyde (188 words) [view diff] case mismatch in snippet view article find links to article

Hideo (2010). "Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains". ACS Medicinal Chemistry Letters. 1

Cholinergic neuron (2,446 words) [view diff] exact match in snippet view article find links to article

distinctive histological hallmarks: Beta amyloid plaques and neurofibrillary tangles. The Beta amyloid plaques are high-molecular weight fibrils and are

Positron emission tomography (8,812 words) [view diff] exact match in snippet view article find links to article

University of Pittsburgh. These probes permit the visualization of amyloid plaques in the brains of Alzheimer's patients and could assist clinicians in

Tarenflurbil (686 words) [view diff] exact match in snippet view article find links to article

potent reducer of levels of beta amyloid, the main constituent of amyloid plaques in Alzheimer's disease, and therefore there was interest in this drug

Gliosis (3,598 words) [view diff] exact match in snippet view article find links to article

unknown. Gliosis and glial scarring occur in areas surrounding the amyloid plaques which are hallmarks of the disease, and postmortem tissues have indicated

Marcus Raichle (999 words) [view diff] exact match in snippet view article find links to article

Raichle ME; Snyder AZ; Morris JC; Head D; Wang S. Mintun MA (2010). "Amyloid plaques disrupt resting state default mode network connectivity in cognitively

Neuroserpin (964 words) [view diff] exact match in snippet view article find links to article

(2006). "Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease". J. Biol. Chem. 281 (39): 29268–77. doi:10.1074/jbc

Sue T. Griffin (513 words) [view diff] exact match in snippet view article find links to article

went on to show how this inflammation contributes to formation of amyloid plaques, neurofibrillary tangles, and Lewy bodies in Alzheimer and Parkinson

Amyloid-related imaging abnormalities (780 words) [view diff] exact match in snippet view article find links to article

become compromised, resulting in increased permeability. Notably, amyloid plaques have been hypothesized to counteract this BBB leakage. However, upon

Li-Huei Tsai (1,749 words) [view diff] exact match in snippet view article find links to article

learning and cognition, profound neural loss in the forebrain, and that amyloid plaques developed within weeks. After moving to MIT in 2006, Tsai began to

Perivascular space (3,935 words) [view diff] exact match in snippet view article find links to article

β-amyloid plaques that characterize Alzheimer's disease. In support of this hypothesis, studies have noted the greater frequency of β-amyloid plaques in

Lisa Mosconi (531 words) [view diff] exact match in snippet view article find links to article

with a specific genetic risk factor for Alzheimer’s disease developed amyloid plaques, linked to the disease, during perimenopause, a time earlier than previously

Visinin-like protein 1 (1,096 words) [view diff] exact match in snippet view article find links to article

(2002). "The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell

Methyl trifluoromethanesulfonate (636 words) [view diff] exact match in snippet view article find links to article

in the production of Pittsburgh Compound B, which first allowed β-amyloid plaques to be imaged in a living brain. Triflate Magic methyl "Methyl

Alzheimer's Disease Neuroimaging Initiative (4,886 words) [view diff] exact match in snippet view article find links to article

which is tested for the AD biomarkers β-amyloid, the main component of amyloid plaques, and tau protein, which forms Alzheimer's brain tau tangles. Magnetic

Florbetapir (18F) (1,412 words) [view diff] exact match in snippet view article

analyzed after death for definitive determination of the presence of amyloid plaques. Of the patients included in the study, 29 who died had autopsies performed

Vascular dementia (2,365 words) [view diff] exact match in snippet view article find links to article

cerebral arteries, leading to breakdown and rupture of the vessels. Since amyloid plaques are a characteristic feature of Alzheimer's disease, vascular dementia

Thioflavin (995 words) [view diff] exact match in snippet view article find links to article

dehydrothiotoluidine with sulfonic acid. It is also used to stain amyloid plaques. Like thioflavin T it binds to amyloid fibrils but not monomers and

Insulin-degrading enzyme (2,076 words) [view diff] exact match in snippet view article find links to article

unclear, though the primary neuropathology observed is the formation of amyloid plaques and neurofibrillary tangles. One hypothesized mechanism of disease

American Association for Geriatric Psychiatry (958 words) [view diff] case mismatch in snippet view article find links to article

articles:[failed verification] Localization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Brains of Living Patients with Alzheimer Disease. Shoghi-Jadid

Causes of Parkinson's disease (3,255 words) [view diff] exact match in snippet view article find links to article

on setparkinsonism and diffuse LBs LBs and LNs; ± tau inclusions; amyloid plaques 30–60 PARK2 Parkin E3 ubiquitin ligase 200+ possible mutations including:

Prevention of dementia (3,923 words) [view diff] exact match in snippet view article find links to article

decrease the level of amyloid beta. This leads to less formation of amyloid plaques seen in Alzheimer's disease. Estrogen may also help in the prevention

2016 in science (16,748 words) [view diff] exact match in snippet view article find links to article

acts as a natural antibiotic in the brain: Alzheimer's-associated amyloid plaques may be a normal part of the immune system, and removing amyloid could

P-type calcium channel (2,825 words) [view diff] exact match in snippet view article find links to article

is a progressive accumulation of β-amyloid protein (Aβ) in brain. Amyloid plaques develop which result in the key symptoms of Alzheimer Disease. Aβ globulomer

Role of microglia in disease (5,051 words) [view diff] exact match in snippet view article find links to article

Plaques result from abnormal proteolytic cleavage of membrane bound APP. Amyloid plaques can stimulate microglia to produce neurotoxic compounds such as cytokines

Neurofibrillary tangle (2,860 words) [view diff] exact match in snippet view article find links to article

parkinsonism linked to chromosome 17 however without detectable β-amyloid plaques. Lytico-Bodig disease (Parkinson-dementia complex of Guam) Ganglioglioma

Transcytosis (2,229 words) [view diff] exact match in snippet view article find links to article

into amyloid-β peptides, including the species that aggregate to form amyloid plaques associated with Alzheimer's disease.[citation needed] Molecules are

Membrane contact site (2,060 words) [view diff] exact match in snippet view article find links to article

resides the disorder of ER-mitochondrial contact sites rather than Amyloid plaques or Neurofibrillary tangles. The presence of enzymes involved in phospholipid

Robert Moir (1,098 words) [view diff] exact match in snippet view article find links to article

causes cold sores and can reach the brain, that might promote both amyloid plaques and tau tangles but was rejected when the third funding reviewer criticized

YoungSoo Kim (1,167 words) [view diff] exact match in snippet view article find links to article

Alzheimer's disease Drug repositioning for chemical-driven clearance of amyloid plaques Chemical-driven outflow of dissociated amyloid burden from brain to

Genetics and abortion (3,581 words) [view diff] exact match in snippet view article find links to article

characterized by the buildup of amyloid precursor protein and subsequent beta-amyloid plaques in the brain. Although most individuals with Down syndrome have these

Intravital microscopy (1,418 words) [view diff] exact match in snippet view article find links to article

to extend toward a laser lesion is reduced in Alzheimer's disease mice. β-amyloid plaques (blue) are always present in brains of Alzheimer patients .

Magnetite (5,373 words) [view diff] exact match in snippet view article find links to article

stress or the production of free radicals. Research suggests that beta-amyloid plaques and tau proteins associated with neurodegenerative disease frequently

Harvey Prize (277 words) [view diff] exact match in snippet view article find links to article

elucidating the structure of amyloid fibrils. Given the involvement of amyloid plaques in numerous diseases, including neurodegenerative disorders, understanding

Aquaporin-4 (3,030 words) [view diff] exact match in snippet view article find links to article

damage and swelling. In people who suffer from Alzheimer's disease, amyloid plaques sometimes develop in brain arteries—a condition is referred to as cerebral

Interleukin 33 (3,015 words) [view diff] exact match in snippet view article find links to article

mice, by reversing the buildup and preventing the new formation of amyloid plaques. Extracellularly, IL-33 is rapidly oxidised. The oxidation process

Mathias Jucker (1,302 words) [view diff] exact match in snippet view article find links to article

PMID 16990547. "Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia". Grathwohl SA, Kälin RE, Bolmont T, Prokop

Down syndrome research (1,809 words) [view diff] exact match in snippet view article find links to article

the precursor of the amyloid protein. Neurofibrillary tangles and amyloid plaques are commonly found in both Down syndrome and Alzheimer's individuals

Agrin (2,328 words) [view diff] exact match in snippet view article find links to article

Rahman MM, Lendel C (August 2021). "Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology". Molecular Neurodegeneration

Early-onset Alzheimer's disease (3,741 words) [view diff] exact match in snippet view article find links to article

then fibrils, beta-sheets, and finally plaques. The presence of β-amyloid plaques in the brain causes the body to recruit and activate microglial cells

The Center for Vital Longevity (761 words) [view diff] exact match in snippet view article find links to article

focuses on predicting the cognitive future of healthy adults by imaging amyloid plaques associated with Alzheimer’s Disease that many healthy people carry

Neuroscience of aging (2,156 words) [view diff] exact match in snippet view article find links to article

altered activation posits that decreased neural efficiency driven by amyloid plaques and decreased dopamine functionality lead to compensatory activation

Lytico-bodig disease (2,175 words) [view diff] exact match in snippet view article find links to article

cyanobacterial toxin BMAA produces dense neurofibrillary tangles and sparse amyloid plaques similar to that found in the brains of Chamorro villagers in Guam who

Low-affinity nerve growth factor receptor (4,235 words) [view diff] exact match in snippet view article find links to article

life and activities. The neuropathological hallmarks of AD include amyloid plaques and neurofibrillary tangles, which lead to neuronal death. Studies

Variant Creutzfeldt–Jakob disease (4,536 words) [view diff] exact match in snippet view article find links to article

confirmatory features should be present: Numerous widespread kuru-type amyloid plaques surrounded by vacuoles in both the cerebellum and cerebrum – florid

Birefringence (6,588 words) [view diff] exact match in snippet view article find links to article

diagnose Duchenne muscular dystrophy. Birefringence can be observed in amyloid plaques such as are found in the brains of Alzheimer's patients when stained

Creutzfeldt–Jakob disease (7,661 words) [view diff] exact match in snippet view article find links to article

protein Not reported Marked accumulation of protease-resistant prion protein Presence of amyloid plaques in brain tissue May be present May be present

Imatinib (6,702 words) [view diff] exact match in snippet view article find links to article

selectively increases the production and accumulation of neurotoxic beta-amyloid plaques, which suggests that molecules which target GSAP and are able to cross

Medical imaging (7,317 words) [view diff] exact match in snippet view article find links to article

metabolic activity by measuring regional glucose metabolism, and beta-amyloid plaques using tracers such as Pittsburgh compound B (PiB). Historically less

Cholesterol signaling (1,790 words) [view diff] exact match in snippet view article find links to article

cholesterol induces APP hydrolysis and the eventual accumulation of amyloid plaques tau phosphorylation. The ApoE isotype4 is the greatest risk factor

Apolipoprotein E (6,407 words) [view diff] exact match in snippet view article find links to article

that "Just as removing smoke does not extinguish a fire, reducing amyloid plaques may not affect the course of Alzheimer's disease." The role that the

3DISCO (2,624 words) [view diff] exact match in snippet view article find links to article

iDISCO was used for functional studies of brain activity or for mapping amyloid plaques, microglia, vasculature and other properties of brains in Alzheimer

Donanemab (2,035 words) [view diff] exact match in snippet view article find links to article

et al. (December 2012). "A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice". Neuron. 76 (5): 908–20. doi:10.1016/j

PLD3 (2,967 words) [view diff] exact match in snippet view article find links to article

PLD3 loss-of-function does not significantly affect the burden of amyloid plaques on AD development in mice. PLD3 loss-of-function in this study did

Anti-amyloid drugs (2,309 words) [view diff] exact match in snippet view article find links to article

brain volume loss. Others say it may be attributed to the reduction in amyloid plaques. Accelerated brain volume loss has been reported with lecanemab, aducanumab

Reelin (15,031 words) [view diff] exact match in snippet view article find links to article

with an earlier study showing the presence of Reelin associated with amyloid plaques in a transgenic AD mouse model. A large genetic study of 2008 showed

Perlecan (11,012 words) [view diff] exact match in snippet view article find links to article

of perlecan may be in different cell types. The development of beta-amyloid plaques on the brain is associated with onset of Alzheimer's disease. These

CRISPR gene editing (19,890 words) [view diff] exact match in snippet view article find links to article

accumulation of intracellular neurofibrillary tangles and extracellular amyloid plaques in the brain. Three pathogenic genes that cause early onset AD in humans

Zhenyu Yue (2,346 words) [view diff] exact match in snippet view article find links to article

Bin; Yue, Zhenyu (July 2023). "Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence". Nature Cell Biology. 25 (7): 963–974

Plasma gelsolin (9,129 words) [view diff] exact match in snippet view article find links to article

Aβ A peptide of 36–43 amino acids that is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. LTA A major constituent

Alzheimer's disease and COVID-19 (3,555 words) [view diff] exact match in snippet view article find links to article

classical RAS. Administration of ACE2 activating drugs can reduce amyloid plaques and prevent cognitive symptoms in mouse models of AD. One of the targets