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searching for Caspase 8 70 found (145 total)

alternate case: caspase 8

Necroptosis (1,667 words) [view diff] exact match in snippet view article find links to article

co-regulation is the ability of caspase 8 to inhibit the formation of the necrosome by cleaving RIPK1. Conversely, caspase 8 inhibition of necroptosis can

Eosinophil cationic protein (2,337 words) [view diff] no match in snippet view article find links to article

epithelial cell death via apoptosis and necrosis. ECP triggers apoptosis by caspase-8 activation through mitochondria-independent pathway. Increases in chromatin

CASP8AP2 (832 words) [view diff] exact match in snippet view article find links to article

identified by its interaction with the death-effector domain (DED) of caspase 8. Researches of FLASH protein suggested that this protein may be a component

TRAIL (1,335 words) [view diff] no match in snippet view article find links to article

(TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is caspase-8-dependent. Caspase-8 activates downstream effector caspases including procaspase-3

KCNK13 (1,000 words) [view diff] no match in snippet view article find links to article

(IL-1β). It also plays a role in cell shrinkage during apoptosis via caspase-8 cleavage. Tandem pore domain potassium channel GRCh38: Ensembl release

FOXO3 (2,272 words) [view diff] no match in snippet view article find links to article

FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP". The Journal of Biological Chemistry. 279 (2): 1513–1525

Baculoviral IAP repeat-containing protein 3 (1,388 words) [view diff] no match in snippet view article find links to article

Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17

Huntingtin-interacting protein 1 (871 words) [view diff] no match in snippet view article find links to article

induction of apoptosis. HIP1’s pro apoptotic effect may involve activation of caspase-8 and a novel HIP1 protein interactor HIPPI. HIP1’s non-pathological activity

Envelope glycoprotein GP120 (2,547 words) [view diff] exact match in snippet view article find links to article

Kumar D, Singhal PC (2009). "Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis". Ren Fail. 31 (4): 303–12. doi:10.1080/08860220902780101

MADD (gene) (1,247 words) [view diff] no match in snippet view article

DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3. The Journal of biological chemistry, 276(50), 47202–47211. https://doi

NUAK1 (808 words) [view diff] exact match in snippet view article find links to article

induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation". Oncogene

Baculoviral IAP repeat-containing protein 2 (1,883 words) [view diff] no match in snippet view article find links to article

Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17

HLA-DR4 (2,119 words) [view diff] no match in snippet view article find links to article

rheumatoid arthritis, Autoimmune hepatitis, type 1 diabetes. DRB1*04:06: caspase-8 autoantibodies silicosis-systemic sclerosis (SSc)-systemic lupus erythematosus

Death receptor 4 (1,026 words) [view diff] no match in snippet view article find links to article

TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8". J. Immunol. 169 (6): 2851–60. doi:10.4049/jimmunol.169.6.2851. PMID 12218097

HHV Latency Associated Transcript (1,471 words) [view diff] no match in snippet view article find links to article

showed that the products from the first 4,658 nucleotides of LAT inhibited caspase-8 and caspase-9 cellular death factors. Further research has shown that

MAP3K14 (1,290 words) [view diff] exact match in snippet view article find links to article

Kumar A, Liu L, Hood L (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812

Early 35 kDa protein (1,249 words) [view diff] no match in snippet view article find links to article

2001). "Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex". Nature. 410 (6827): 494–7. doi:10.1038/35068604. PMID 11260720

Ectodysplasin A2 receptor (525 words) [view diff] exact match in snippet view article find links to article

"Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism". J. Biol. Chem. 279 (40): 41873–81. doi:10.1074/jbc

Low-affinity nerve growth factor receptor (4,235 words) [view diff] exact match in snippet view article find links to article

allowing aggregation and activation of Caspase 8 and subsequent activation of the Caspase cascade. However, Caspase 8 induction does not appear to be involved

IKK2 (1,527 words) [view diff] exact match in snippet view article find links to article

Liu L, Hood L (September 2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812

Msh homeobox 2 (1,566 words) [view diff] no match in snippet view article find links to article

deletion of the Msx2 gene increased apoptosis by enhancing the caspase-3/caspase-8 signaling pathway". The Journal of International Medical Research. 46

Nigella (1,303 words) [view diff] no match in snippet view article find links to article

November 2005). "Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells"

Autocrine signaling (2,105 words) [view diff] no match in snippet view article find links to article

TNFα signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis. Recent studies have reported

Farnesoid X receptor (2,072 words) [view diff] no match in snippet view article find links to article

Algeciras-Schimnich A, Ke N, Reed JC, et al. (February 2002). "Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional

Abexinostat (685 words) [view diff] no match in snippet view article find links to article

Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells". International Journal of Cell Biology. 2010:

CD48 (2,192 words) [view diff] exact match in snippet view article find links to article

Hwang YI, Chang KY, Lee WJ (2002). "CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner

Tumor necrosis factor receptor 1 (2,146 words) [view diff] exact match in snippet view article find links to article

Liu L, Hood L (September 2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–4460. doi:10.1038/sj.onc.1203812

Plectin (2,459 words) [view diff] exact match in snippet view article find links to article

"Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis". Molecular

RFFL (483 words) [view diff] no match in snippet view article find links to article

PMID 15302935. McDonald ER, El-Deiry WS (April 2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands

Phytosphingosine (161 words) [view diff] exact match in snippet view article find links to article

Weon-Ik (February 2003). "Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells". Clinical Cancer

CCAR1 (563 words) [view diff] no match in snippet view article find links to article

PMID 14743216. S2CID 11683986. McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands

Boswellic acid (897 words) [view diff] no match in snippet view article find links to article

(2002). "Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer

Centroblast (638 words) [view diff] exact match in snippet view article find links to article

Razq; Gommerman, Jennifer L.; Martin, Alberto (2013-12-15). "AID and Caspase 8 Shape the Germinal Center Response through Apoptosis". The Journal of

Emricasan (473 words) [view diff] no match in snippet view article find links to article

Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, et al. (May 2016). "The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce

RNF34 (574 words) [view diff] no match in snippet view article find links to article

1038/ng1285. PMID 14702039. McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands

CRADD (939 words) [view diff] exact match in snippet view article find links to article

Kumar A, Liu L, Hood L (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812

UVB-induced apoptosis (1,246 words) [view diff] no match in snippet view article find links to article

Reduction of potassium ions promotes apoptosis and the synthesis of initiator caspase-8 and the effector caspase-3. A study reported in the International Journal

David Wallach (967 words) [view diff] no match in snippet view article find links to article

family. Among the molecules first cloned at his lab are the protease caspase-8, the adaptor protein FADD (MORT1), the cell-death inhibitory protein cFlip

FAF1 (934 words) [view diff] no match in snippet view article find links to article

PMID 8524870. Juo P, Kuo CJ, Yuan J, Blenis J (1998). "Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade". Curr. Biol

Pramipexole (4,584 words) [view diff] no match in snippet view article find links to article

PMID 7538908. Wang L, Du F, Wang X (May 2008). "TNF-alpha induces two distinct caspase-8 activation pathways". Cell. 133 (4): 693–703. doi:10.1016/j.cell.2008

PYCARD (1,338 words) [view diff] no match in snippet view article find links to article

G, Inohara N (2003). "ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis". Biochem. Biophys. Res. Commun. 303 (1): 69–73. doi:10

David A. Cheresh (535 words) [view diff] exact match in snippet view article find links to article

M., Cheresh,D.A. Potentiation of neuroblastoma metastasis by loss of caspase 8. 'Nature' 439:95-99, 2006. Alavi, A., Hood, J.D., Frausto, R., Stupack

Cardiolipin (3,792 words) [view diff] no match in snippet view article find links to article

apoptosis of the cells, as evidenced by cytochrome c (cyt c) release, Caspase-8 activation, MOMP induction and NLRP3 inflammasome activation. During apoptosis

Douglas R. Green (954 words) [view diff] no match in snippet view article find links to article

Green, D. R. (2014). "RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3". Cell. 157 (5): 1189–202. doi:10.1016/j.cell.2014.04.018. PMC 4068710

Pseudoenzyme (1,389 words) [view diff] no match in snippet view article find links to article

conventional protease cFLIP binds and inhibits the cysteine protease, Caspase-8, to block extrinsic apoptosis Regulation of protein localisation in a

Rhododendrol (2,161 words) [view diff] case mismatch in snippet view article find links to article

expression of caspase-3 and caspase-8. Caspase proteins are crucial mediators of apoptosis, with caspase-3 and caspase-8 being death proteases. Considering

SUMO1 (2,334 words) [view diff] no match in snippet view article find links to article

Kuo CJ, Yuan J, Blenis J (September 1998). "Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade". Current

South Park (14,897 words) [view diff] no match in snippet view article find links to article

Wikholm; et al. (February 18, 2003). "kep1 interacts genetically with dredd/Caspase-8, and kep1 mutants alter the balance of dredd isoforms". Proc Natl Acad

Cantharidin (3,902 words) [view diff] no match in snippet view article find links to article

TNF-α (TNF = tumor necrosis factor), FASL, ROS, caspase-4, caspase-6, caspase-8, caspase-9, caspase-12, protein kinase R-like ER kinase, inositol-requiring

DFFA (1,405 words) [view diff] no match in snippet view article find links to article

"Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas". The Journal of Pathology. 192 (2):

Reactive oxygen species (8,525 words) [view diff] exact match in snippet view article find links to article

subsequent recruitment of Fas-associated protein with death domain and caspase 8 as well as apoptosis induction. In the intrinsic pathway, ROS function

Laucysteinamide A (500 words) [view diff] exact match in snippet view article find links to article

(2008-02-19). "The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8". Proceedings of the National Academy of Sciences. 105 (7): 2313–2318

Protein domain (8,443 words) [view diff] case mismatch in snippet view article find links to article

(DED-DED). Caspase proteases trigger apoptosis via proteolytic cascades. Pro-caspase-8 and pro-caspase-9 bind to specific adaptor molecules via DED domains,

P3 peptide (1,340 words) [view diff] no match in snippet view article find links to article

Kusiak JW (2002). "Aβ 17–42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis". Brain. 125 (9): 2036–43. doi:10.1093/brain/awf205

Jean Pieters (1,182 words) [view diff] exact match in snippet view article find links to article

Wymann, Matthias P; Pieters, Jean (21 December 2021). "Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently

C-Raf (8,674 words) [view diff] no match in snippet view article find links to article

Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J (June 2000). "The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways"

American ginseng (4,949 words) [view diff] no match in snippet view article find links to article

HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage". Toxicology and Applied Pharmacology. 194

AIM2 (2,826 words) [view diff] no match in snippet view article find links to article

To form the PANoptosome, the AIM2 inflammasome further interacts with caspase-8, FADD, RIPK3, and RIPK1 in response to specific pathogens, including Francisella

Imd pathway (2,455 words) [view diff] no match in snippet view article find links to article

orthologue = Tak1 TAB2: human orthologue = TAB2 Dredd: human orthologue = caspase-8 FADD: human orthologue = FADD Key/Ikkγ: human orthologue = NEMO Ird5:

Apoptosome (4,346 words) [view diff] no match in snippet view article find links to article

Wolfgang J.; Schulze-Osthoff, Klaus; Lauer, Ulrich M. (16 August 2002). "Caspase-8 and Apaf-1-independent Caspase-9 Activation in Sendai Virus-infected Cells

Molecular Inversion Probe (4,910 words) [view diff] no match in snippet view article find links to article

between the polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and the risk for endometrial cancer. A recent study has demonstrated

Serpin (14,371 words) [view diff] no match in snippet view article find links to article

serine (granzyme B; albeit weakly) and cysteine proteases (caspase 1 and caspase 8). In comparison to their mammalian counterparts, viral serpins contain

MAP4K4 (3,301 words) [view diff] exact match in snippet view article find links to article

Liu L, Hood L (September 2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812

Netrin receptor DCC (5,119 words) [view diff] no match in snippet view article find links to article

dependent on either the mitochondrial apoptosis pathway or the death receptor/caspase-8 pathway. In the absence of ligand, DCC interacts with caspase-9 (likely

Seamus Martin (biochemist) (1,192 words) [view diff] no match in snippet view article

Mitophagy. Molecular Cell 55:451-66. Henry CM and Martin SJ (2017) Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory

Anticancer gene (6,791 words) [view diff] no match in snippet view article find links to article

proteins that contain a cytoplasmic death domain. Once TRAIL is bound, Fas, caspase-8, and caspase-10 associate with the death domain forming death-inducing

Arsenic trioxide (medication) (6,680 words) [view diff] exact match in snippet view article

Kiyoi, H.; Saito, H.; Naoe, T. (2000). "Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis". Leukemia. 14 (10):

Kidney ischemia (4,566 words) [view diff] exact match in snippet view article find links to article

risk factors in the development of ischemic injury. Activation of pro-caspase 8 initiates apoptosis via signaling from cell-surface death receptors such

Role of microglia in disease (5,130 words) [view diff] no match in snippet view article find links to article

Nitsch R, Bechmann I, Weber JR, Henneke P (November 2007). "TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia"

Fungi of New Zealand (7,903 words) [view diff] exact match in snippet view article find links to article

Anfal; Hafedth, Qutaiba (1 July 2019). "Immunohistochemical Detection of Caspase 8 Expression and Apoptotic index Activities of Tephrosia purpurea Crude