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searching for C-terminus 319 found (1631 total)

alternate case: c-terminus

Pax genes (1,191 words) [view diff] exact match in snippet view article find links to article

and PAX7), a complete homeodomain to the C-terminus. An octapeptide as well as a Pro-Ser-Thr-rich C terminus may also be present. Pax proteins are important

Benign familial neonatal seizures (2,580 words) [view diff] exact match in snippet view article find links to article

1, primarily located in the voltage sensitive S4 segment through the C-terminus. Of these mutations, 5 are nonsense mutations, 13 are missense mutations

GPR87 (297 words) [view diff] no match in snippet view article find links to article

extracellular N terminus, 7 transmembrane regions, and an intracellular C terminus.[supplied by OMIM] GRCh38: Ensembl release 89: ENSG00000138271 – Ensembl

D-alanine—D-alanine ligase (338 words) [view diff] exact match in snippet view article find links to article

D-alanine—D-alanine ligase is thought to be involved in substrate binding, while the C-terminus is thought to be a catalytic domain. As of late 2007, 8 structures have

Carboxypeptidase B (264 words) [view diff] exact match in snippet view article find links to article

preferentially cleaves off basic amino acids arginine and lysine from the C-terminus of a peptide. This enzyme is secreted by the pancreas, and it travels

Type XVIII collagen (753 words) [view diff] no match in snippet view article find links to article

collagen which can be cleaved to form endostatin. The endostatin is from the c terminus end of the collagen XVIII, and is known to have an inhibitory effect on

Signal peptide (1,777 words) [view diff] exact match in snippet view article find links to article

long) present at the N-terminus (or occasionally nonclassically at the C-terminus or internally) of most newly synthesized proteins that are destined toward

Periplakin (1,064 words) [view diff] exact match in snippet view article find links to article

N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein

Pancreatic lipase family (1,721 words) [view diff] no match in snippet view article find links to article

toward the N terminus is an α/β hydrolase, whereas the one toward the C terminus plays a role in binding to colipase, a protein needed in order for the

BACH2 (995 words) [view diff] exact match in snippet view article find links to article

N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus. GRCh38: Ensembl release 89: ENSG00000112182 – Ensembl, May 2017 GRCm38:

TOX3 (767 words) [view diff] exact match in snippet view article find links to article

structure by unwinding and bending DNA. The protein TOX3 has a glutamine-rich C-terminus due to CAG repeats. TOX3 is located on human chromosome band 16q12.1.

Cyanogen bromide (1,486 words) [view diff] exact match in snippet view article find links to article

used to modify biopolymers, fragment proteins and peptides (cuts the C-terminus of methionine), and synthesize other compounds. The compound is classified

P73 (1,132 words) [view diff] exact match in snippet view article find links to article

differing at either at the C- or the N-terminus. Currently, six different C-terminus splicing variants have been found in normal cells. The p73 gene encodes

TRPC (1,184 words) [view diff] exact match in snippet view article find links to article

TRP box motif containing the invariant EWKFAR sequence at the proximal C-terminus. These channels are non-selectively permeable to cations, with a prevalence

Protein tag (2,683 words) [view diff] exact match in snippet view article find links to article

end of the target protein, so they are either C-terminus or N-terminus specific or are both C-terminus and N-terminus specific. Some tags are also inserted

Congenital stationary night blindness (2,878 words) [view diff] exact match in snippet view article find links to article

LRRs (LRR1-11) flanked by cysteine-rich LRRs (LRRNT and LRRCT). At the C-terminus of the protein there is a putative GPI anchor site. Although the function

Neuromedin N (521 words) [view diff] exact match in snippet view article find links to article

whose sequences are found on the pro neurotensin/neuromedin N precursor C-terminus. Both sequences of neuromedin N as well as neurotensin are flanked by

MAP3K4 (1,109 words) [view diff] no match in snippet view article find links to article

MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression

Generalized epilepsy with febrile seizures plus (3,419 words) [view diff] case mismatch in snippet view article find links to article

1807delMFYE C-Terminus F1808L C-Terminus Yes Hyperexcitable W1812G C-Terminus F1831S C-Terminus M1841T C-Terminus S1846fsX1856 C-Terminus R1882X C-Terminus D1886Y

EPI-001 (1,307 words) [view diff] exact match in snippet view article find links to article

the anitens novel molecular mechanism from anti androgens that bind the C-terminus ligand-binding domain and have the stem class "lutamide" (such as flutamide

Integrase (1,288 words) [view diff] exact match in snippet view article find links to article

protein consisting of three domains- N-terminus, catalytic core domain, and C-terminus, which each have distinct properties and functions contributing to the

NFKB2 (1,276 words) [view diff] exact match in snippet view article find links to article

hereditary endocrine and immuneodeficiences. The mutation occurs at the C-terminus of NFKB2 and it causes common variable immunodeficienciency which in turn

Versican (2,427 words) [view diff] no match in snippet view article find links to article

Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene. Versican is a large

Hefutoxin (276 words) [view diff] exact match in snippet view article find links to article

an amidated C terminus and is the shortest scorpion toxin reported so far. The κ- hefutoxin2 is built up of 23 residues with free C-terminus. The toxin

SYT1 (1,503 words) [view diff] no match in snippet view article find links to article

2010. Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (Mar 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to

DnaC (1,405 words) [view diff] exact match in snippet view article find links to article

prokaryotic loading factor found in Escherichia coli that complexes with the C-terminus of helicase dnaB during the initial stages of prokaryotic DNA replication

Claudin (1,301 words) [view diff] exact match in snippet view article find links to article

epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudins are small (20–24/27 kilodalton (kDa)) transmembrane

GRIN1 (1,306 words) [view diff] exact match in snippet view article find links to article

alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing

FLAG-tag (846 words) [view diff] exact match in snippet view article find links to article

blotting. The peptide sequence of the FLAG-tag from the N-terminus to the C-terminus is: DYKDDDDK (1012 Da). Additionally, FLAG-tags may be used in tandem

SNX6 (221 words) [view diff] no match in snippet view article find links to article

the retromer complex. The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation

Orange carotenoid N-terminal domain (531 words) [view diff] no match in snippet view article find links to article

residues from the N-terminus and approximately 150 residues from the C terminus. This domain is implicated in binding the phycobilisome complex, which

Beta sheet (3,137 words) [view diff] exact match in snippet view article find links to article

C-terminus, β-strands too can be said to be directional. They are usually represented in protein topology diagrams by an arrow pointing toward the C-terminus

Integral membrane protein (1,144 words) [view diff] no match in snippet view article find links to article

have the N terminus on the far side and C terminus on the cytosolic side. Group II proteins have the C terminus on the far side and N terminus in the cytosol

Cupiennin (740 words) [view diff] exact match in snippet view article find links to article

are characterised by a more hydrophobic N-terminal chain region and a C-terminus composed preferentially of polar and charged residues. Their distinguishing

Phosphofructokinase 2 (4,253 words) [view diff] exact match in snippet view article find links to article

activated which phosphorylates either Serine 466 or Serine 483 in the C-terminus. Alternatively, Protein Kinase B may also phosphorylate these regulatory

GIPC1 (1,893 words) [view diff] exact match in snippet view article find links to article

the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling. GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS

Lens fiber major intrinsic protein (860 words) [view diff] exact match in snippet view article find links to article

PMID 1505237. Girsch SJ, Peracchia C (1992). "Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26". Curr. Eye Res. 10 (9):

Tropomodulin (1,575 words) [view diff] exact match in snippet view article find links to article

N-terminus half and a C-Terminus half. The N-terminus half is seen to be mostly extended, unstructured, and flexible and the C-terminus half is seen to be

Mutant protein (128 words) [view diff] exact match in snippet view article find links to article

leading to disease) or wide-range amino acid changes by e.g. truncation of C-terminus after introducing premature stop codon. Site-directed mutagenesis Phi

BRCT domain (276 words) [view diff] no match in snippet view article find links to article

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that

ADF/Cofilin family (1,915 words) [view diff] no match in snippet view article find links to article

and includes the central alpha helix, the N-terminus extension, and the C terminus helix. The N-terminus extension consists of a tilted loop that facilitates

M protein (Streptococcus) (1,652 words) [view diff] exact match in snippet view article

molecule is the M protein produced by certain streptococcal bacteria. At its C-terminus within the cell wall, M proteins embody a motif that is now known to be

Holin (1,253 words) [view diff] exact match in snippet view article find links to article

transmembrane domains (TMDs) with the N-terminus in the periplasm and the C-terminus in the cytoplasm. They generally have over 95 residues. Examples of class

DNA polymerase (7,100 words) [view diff] exact match in snippet view article find links to article

C-terminus "polymerase relic" region, despite being unnecessary for polymerase activity, is thought to be essential to cell vitality. The C-terminus region

Substance P (5,300 words) [view diff] exact match in snippet view article find links to article

Gln Gln Phe Phe Gly Leu Met (RPKPQQFFGLM) with an amide group at the C-terminus. Substance P is released from the terminals of specific sensory nerves

ATM serine/threonine kinase (5,695 words) [view diff] exact match in snippet view article find links to article

repeats directly bind to the C-terminus of NBS1. The FAT domain interacts with ATM's kinase domain to stabilize the C-terminus region of ATM itself. The

HIV-1 protease (2,369 words) [view diff] exact match in snippet view article find links to article

PR. PR is located between the reverse transcriptase (which is at the C-terminus of PR) and the p6pol (which is at the N-terminus of PR) of the transframe

Ferredoxin fold (81 words) [view diff] exact match in snippet view article find links to article

which adopts a ferredoxin fold with an extra β-strand at the C-terminus (shown in red). The ribbon is colored from blue (N-terminus) to red (C-terminus).

Glutamate decarboxylase (4,776 words) [view diff] no match in snippet view article find links to article

This interaction occurs at the 30-50bp CAM-binding domain (CaMBD) in its C terminus and is necessary for proper regulation of GABA production. Unlike vertebrates

Transmembrane protein (2,278 words) [view diff] no match in snippet view article find links to article

have the N terminus on the far side and C terminus on the cytosolic side. Group II proteins have the C terminus on the far side and N terminus in the cytosol

Coronavirus envelope protein (1,897 words) [view diff] exact match in snippet view article find links to article

The balance of evidence suggests the most common orientation has the C-terminus oriented toward the cytoplasm. Studies of SARS-CoV-2 E protein are consistent

Interleukin 15 (4,458 words) [view diff] exact match in snippet view article find links to article

a 316 bp 5'-untranslated region (UTR), 486 bp coding sequence and the C-terminus 400 bp 3'-UTR region. The other isoform (IL-15 SSP) has a short signal

Pol (HIV) (157 words) [view diff] exact match in snippet view article

The Gag-Pol region containing the protease gene flanked by p6pol at the N-terminus and reverse transcriptase at the C-terminus.

Ubiquitin D (2,244 words) [view diff] exact match in snippet view article find links to article

an ATP-dependent ubiquitin activating enzyme. The carboxyl terminal (C-terminus) of ubiquitin is linked to the cysteine residue of the E1 protein by a

Tyrocidine (1,351 words) [view diff] exact match in snippet view article find links to article

a head-to-tail fashion involving the N-terminus of the D-Phe1 and the C-terminus of the L-Leu10 (See figure 4). There is no general biochemical solution

Α-Amylase (2,302 words) [view diff] no match in snippet view article find links to article

C terminus. This domain is organised as a five-stranded antiparallel β-sheet. Several α-amylases contain an all-β domain, usually at the C terminus.

Phage display (4,630 words) [view diff] exact match in snippet view article find links to article

by adding an 8-10 amino acid linker between the cDNA and pIII at the C-terminus. pVIII is the main coat protein of Ff phages. Peptides are usually fused

COPG2 (1,032 words) [view diff] exact match in snippet view article find links to article

"Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77–85. doi:10.1078/0171-9335-00222. PMID 11893085

Phospholipase C (2,691 words) [view diff] exact match in snippet view article find links to article

N-terminus. Alpha-toxin has an additional 120 residues in the C-terminus. The C-terminus of the alpha-toxin has been reported as a "C2-like" domain, referencing

Muscarinic toxin 7 (214 words) [view diff] no match in snippet view article find links to article

rendered with BIOVA Discovery Visual Studio. Muscarinic Toxin 7 (yellow ribbon) bound to the Muscarinic M1 receptor (Red -> Blue indicates N -> C terminus)

Essential thrombocythemia (2,154 words) [view diff] no match in snippet view article find links to article

that cause a reading shift, which then leads to the formation of a novel C terminus. There are two common types of CALR mutations, type 1 and type 2. Type

Epiregulin (1,149 words) [view diff] exact match in snippet view article find links to article

homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands

ATP2A2 (228 words) [view diff] exact match in snippet view article find links to article

hydrolase activity ATP binding P-type calcium transporter activity protein C-terminus binding lutropin-choriogonadotropic hormone receptor binding P-type proton-exporting

Delta atracotoxin (2,268 words) [view diff] exact match in snippet view article find links to article

and Tyr25, and is flanked by Ile21 at its N-terminus and Trp7 near its C-terminus, so this region represents a significant non-polar surface on the molecule

Glucagon-like peptide-1 receptor (4,085 words) [view diff] exact match in snippet view article find links to article

domains (TM1-TM7), an extracellular N-terminus, and an intracellular C-terminus. It belongs to the class B family of G protein-coupled receptors, also

NOBOX (2,187 words) [view diff] no match in snippet view article find links to article

encoded by 8 exons. It has a proline rich C terminus and contains putative SH3 and WW domains. This C terminus is believed to be critical in its transcriptional

Autochaperone (146 words) [view diff] no match in snippet view article find links to article

domain. When the passenger domain is translocated, starting with its C terminus, the autochaperone domain is first out. This would result in the formation

COPG (997 words) [view diff] exact match in snippet view article find links to article

"Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2). Germany: 77–85. doi:10.1078/0171-9335-00222

L-type calcium channel (2,004 words) [view diff] exact match in snippet view article find links to article

EF-hand motifs on the N-terminus. Both the N and C terminus are in the cytosolic space with the C-terminus being much longer than the N-terminus. The β subunit

Ku (protein) (1,707 words) [view diff] exact match in snippet view article

the opposite subunit. In some cases a fourth domain is present at the C-terminus, which binds to DNA-dependent protein kinase catalytic subunit. Both subunits

UBE2D3 (1,253 words) [view diff] exact match in snippet view article find links to article

Wang X, Shi Y, Wang J, Huang G, Jiang X (Sep 2008). "Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation"

CENPF (1,346 words) [view diff] no match in snippet view article find links to article

1006/bbrc.1995.1959. PMID 7612011. Zhu X, Chang KH, He D, et al. (1995). "The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore

GOPC (1,213 words) [view diff] no match in snippet view article find links to article

PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM] GOPC has

Cholecystokinin (3,029 words) [view diff] exact match in snippet view article find links to article

resides in the C-terminus of the peptide. Most CCK peptides have a sulfate group attached to a tyrosine located seven residues from the C-terminus (see tyrosine

Metabotropic receptor (625 words) [view diff] no match in snippet view article find links to article

terminus is located on the extracellular side of the membrane and its C terminus is on the intracellular side. The 7 transmembrane spanning domains, with

Group-specific antigen (1,572 words) [view diff] exact match in snippet view article find links to article

needed] The p24 capsid protein (CA) is a 24 kDa protein fused to the C-terminus of MA in the unprocessed HIV Gag polyprotein. After viral maturation,

RHEB (2,661 words) [view diff] exact match in snippet view article find links to article

hypervariable region ending at the C-terminus in a CAAX motif (C – cysteine, A – aliphatic amino acid, X – C-terminus amino acid). The protein is a lipid-anchored

KLK6 (1,866 words) [view diff] no match in snippet view article find links to article

Arg is towards the N terminus and a general amino acid is towards the C terminus. It is believed to follow a similar pathway to other serine-type proteases

EIF3M (597 words) [view diff] no match in snippet view article find links to article

1038/msb4100134. PMC 1847948. PMID 17353931. Perez-Romero P, Fuller AO (2005). "The C terminus of the B5 receptor for herpes simplex virus contains a functional region

Ras GTPase (4,042 words) [view diff] exact match in snippet view article find links to article

Tripeptide (aaX) is then cleaved from the C-terminus by a specific prenyl-protein specific endoprotease and the new C-terminus is methylated by a methyltransferase

WDTC1 (347 words) [view diff] exact match in snippet view article find links to article

protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus. Reduced expression or disruption of WDTC1 gene is associated with obesity

Physalaemin (546 words) [view diff] case mismatch in snippet view article find links to article

membrane, PHY takes on a helical confirmation from the Pro4 residue to the C-Terminus. This helical conformation is essential to allow the binding of PHY to

Cadherin cytoplasmic region (200 words) [view diff] exact match in snippet view article find links to article

biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding

STUB1 (1,481 words) [view diff] no match in snippet view article find links to article

containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). The CHIP protein encoded by this gene binds

Glutamine synthetase (3,036 words) [view diff] exact match in snippet view article find links to article

rings of GS together. Each subunit possesses a C-terminus and an N-terminus in its sequence. The C-terminus (helical thong) stabilizes the GS structure by

Hypomagnesemia with secondary hypocalcemia (1,033 words) [view diff] exact match in snippet view article find links to article

Q1260fsX1283 C-terminus , c.del Ex 25 - 27 C-terminus c.del Ex 26 Y1533X C-terminus No c.5017-18delT L1673fsX1675 C-terminus No c.del Ex 31 + 32 C-terminus No c

Occludin (2,898 words) [view diff] exact match in snippet view article find links to article

extracellular domain 2 (48 aa) transmembrane domain 4 (22 aa) C-terminus domain (257 aa) The C-terminus domain has been shown experimentally to be required for

Peptide YY (2,673 words) [view diff] exact match in snippet view article find links to article

and Y5 receptors. It is thought that the Y1 receptor requires both the C-terminus and N-terminus for recognition, binding and then subsequent activation

Exosortase (399 words) [view diff] exact match in snippet view article find links to article

sortases. Archaeosortase A recognizes the signal PGF-CTERM, found at the C-terminus of some archaeal S-layer proteins. Following processing by archaeosortase

TRPP (427 words) [view diff] exact match in snippet view article find links to article

All of the members of this group contain a coiled coil region in their C-terminus involved in the interaction with the polycystin-1 group. TRPP1 and TRPP3

Glucagon-like peptide-2 receptor (812 words) [view diff] no match in snippet view article find links to article

Yusta B, Drucker DJ (Jun 2005). "The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced

ABCA1 (2,084 words) [view diff] exact match in snippet view article find links to article

relatively unknown, there has been some determination of the c-terminus. The ABCA1 c-terminus contains a PDZ domain, responsible for mediating protein-protein

Carboxypeptidase (816 words) [view diff] exact match in snippet view article find links to article

containing the sequence -Pro-Xaa (Pro is proline, Xaa is any amino acid on the C-terminus of a peptide) is called "prolyl carboxypeptidase". Some, but not all,

Beta-propeller (2,034 words) [view diff] exact match in snippet view article find links to article

attributed to increased hydrophobic interactions due to mutations at the C-terminus of the beta-propeller. The beta-propeller domain of the influenza virus

SYT13 (503 words) [view diff] no match in snippet view article find links to article

extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include

Ginger milk curd (417 words) [view diff] exact match in snippet view article find links to article

occurs, the ginger protease cuts open the κ-casein so that the hydrophilic C-terminus and the hydrophobic N-terminus separate. This disrupts the stability of

S-tag (216 words) [view diff] exact match in snippet view article find links to article

distinct structure. On DNA-level the S-tag can be attached to the N- or C-terminus of any protein. After gene expression, such a tagged protein can be detected

LOXL4 (660 words) [view diff] exact match in snippet view article find links to article

collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that

NHL repeat (461 words) [view diff] exact match in snippet view article find links to article

type II, ascorbate-dependent monooxygenase family which catalyse the C-terminus alpha-amidation of biological peptides. In many it occurs in tandem arrays

Glia maturation factor (115 words) [view diff] exact match in snippet view article find links to article

diagram of the crystal structure of GMFG. Spectral coloring is from blue (N-terminus) to red (C-terminus). Secondary structural elements are indicated

Terminus (play) (197 words) [view diff] no match in snippet view article

daughter (B), and a serial killer who has sold his soul to the Devil (C). Terminus premiered at the Abbey Theatre in Dublin on 9 June 2007, before transferring

PDLIM5 (1,032 words) [view diff] no match in snippet view article find links to article

100-amino acid PDZ domain in the N-terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found

GIPC3 (860 words) [view diff] no match in snippet view article find links to article

the GIPC3 gene. GIPC3 is a member of the GIPC (GAIP-interacting protein C terminus) gene family that also includes GIPC1 and GIPC2. The encoded protein,

CLCN5 (4,885 words) [view diff] exact match in snippet view article find links to article

(named A to R), an intracellular N- terminal domain and a cytoplasmic C-terminus containing two cystathionine beta-synthase (CBS) domains which are known

Opioid receptor (4,427 words) [view diff] exact match in snippet view article find links to article

extracellular loops, three intracellular loops, and an intracellular carboxyl C-terminus. Three GPCR extracellular loops provide a compartment where signaling

PIP5K1C (842 words) [view diff] exact match in snippet view article find links to article

focal adhesion plaques, and binds the FERM domain of talin through its C-terminus. GRCh38: Ensembl release 89: ENSG00000186111 – Ensembl, May 2017 GRCm38:

KKXX (amino acid sequence) (311 words) [view diff] no match in snippet view article

KKXX and for some proteins XKXX is a target peptide motif located in the C terminus in the amino acid structure of a protein responsible for retrieval of

Glypican 2 (865 words) [view diff] exact match in snippet view article find links to article

gene is at locus 7q22.1 and encodes for a 579 amino acid protein. The C-terminus of GPC2 has the GPI attachment site, at G554, and the N-terminus encodes

KSR1 (553 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function metal ion binding protein C-terminus binding protein binding ATP binding MAP-kinase scaffold activity protein kinase activity

INPP5B (627 words) [view diff] exact match in snippet view article find links to article

associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been

Insulin receptor substrate 1 (4,304 words) [view diff] exact match in snippet view article find links to article

domain ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail. Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous

TRIM27 (1,049 words) [view diff] exact match in snippet view article find links to article

germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the

TOP3B (743 words) [view diff] exact match in snippet view article find links to article

aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct

Interferon-alpha/beta receptor (2,617 words) [view diff] exact match in snippet view article find links to article

degron, preventing its internalization. Following receptor agonism, the C-terminus of IFNAR is phosphorylated, followed by its ubiquitination and internalization

Pertactin (430 words) [view diff] exact match in snippet view article find links to article

is region 2 (R2) which contains Pro-Gln-Pro (PQP) repeats towards the C-terminus. This protein’s contribution to immunity is still premature. Reports suggest

Rhinolophus bat coronavirus HKU2 (267 words) [view diff] exact match in snippet view article find links to article

spike protein shares similar deletions with group 2 coronaviruses in the C-terminus. Murinae Zoonosis Lau, SK; Woo, PC; Li, KS; Huang, Y; Wang, M; Lam, CS;

HIC2 (577 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function DNA binding protein C-terminus binding metal ion binding nucleic acid binding DNA-binding transcription factor activity

EIF2A (1,000 words) [view diff] no match in snippet view article find links to article

Weiser DC, Sikes S, Li S, Shenolikar S (Nov 2004). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional

BAG2 (720 words) [view diff] no match in snippet view article find links to article

BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein

TATA-binding protein (3,218 words) [view diff] exact match in snippet view article find links to article

of the protein. This region modulates the DNA binding activity of the C-terminus, and modulation of DNA-binding affects the rate of transcription complex

LOXL3 (658 words) [view diff] exact match in snippet view article find links to article

collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that

SYT3 (679 words) [view diff] no match in snippet view article find links to article

PMID 10531343. Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to

Glycolipid (1,589 words) [view diff] exact match in snippet view article find links to article

lipid moiety bound to a carbohydrate complex. They can be bound to the C-terminus of a protein and have various functions associated with the different

Alpha helix (5,204 words) [view diff] exact match in snippet view article find links to article

clear that all the backbone carbonyl oxygens point downward (toward the C-terminus) but splay out slightly, and the H-bonds are approximately parallel to

KLRC2 (1,230 words) [view diff] no match in snippet view article find links to article

proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family

Transcription factor Sp1 (3,441 words) [view diff] exact match in snippet view article find links to article

trans-activation. SP1 most notably contains three zinc finger protein motifs at its C-terminus, by which it binds directly to DNA and allows for interaction of the protein

Nociceptin receptor (3,363 words) [view diff] no match in snippet view article find links to article

the nociceptin receptor by alanine substitution of glutamine 286 at the C terminus of transmembrane segment VI: evidence from a site-directed mutagenesis

Rubicon homology domain (444 words) [view diff] exact match in snippet view article find links to article

and form at least 4 zinc finger motifs. Amino acid residues toward the C-terminus of the RH domain of Rubicon have been shown to be essential for interaction

Transcription factor Sp1 (3,441 words) [view diff] exact match in snippet view article find links to article

trans-activation. SP1 most notably contains three zinc finger protein motifs at its C-terminus, by which it binds directly to DNA and allows for interaction of the protein

Rubicon homology domain (444 words) [view diff] exact match in snippet view article find links to article

and form at least 4 zinc finger motifs. Amino acid residues toward the C-terminus of the RH domain of Rubicon have been shown to be essential for interaction

BAG5 (581 words) [view diff] exact match in snippet view article find links to article

shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three

Cysteine-rich protein (757 words) [view diff] exact match in snippet view article find links to article

secretion peptide signal at the N-terminus and a cysteine-rich region at the C-terminus. In an oxidising environment cysteines cross-link to form disulphide bonds

SCNN1B (3,035 words) [view diff] exact match in snippet view article find links to article

ubiquitin-protein ligase named Nedd4-2. Nedd4-2 ligates ubiquitin to the C-terminus of the ENaC subunit which marks the protein for degradation. At present

Limulus clotting factor C (394 words) [view diff] exact match in snippet view article find links to article

initiating a cascade leading to coagulin formation. From the N-terminus to the C-terminus, the domains are: EGF-like domain 3 Sushi domains one LCCL domain and

Rab (G-protein) (1,327 words) [view diff] exact match in snippet view article

Specifically, Rabs are anchored via prenyl groups on two cysteines in the C-terminus. Rab escort proteins (REPs) deliver newly synthesized and prenylated Rab

KLRC4 (941 words) [view diff] no match in snippet view article find links to article

proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located

RCBTB1 (577 words) [view diff] exact match in snippet view article find links to article

gene in vascular smooth muscle cells induced cellular hypertrophy. The C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this

Thermosome (602 words) [view diff] exact match in snippet view article find links to article

the second ring when ADP is bound to the first ring. The N-terminus and C-terminus of thermosomes are arranged in an anti-parallel fashion and their interactions

INTS6 (665 words) [view diff] exact match in snippet view article find links to article

a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In

Ku70 (2,195 words) [view diff] exact match in snippet view article find links to article

Bax-dependent apoptosis. Interactions between Ku70 and Bax occurs in the C-terminus of Ku70 and the N-terminus of Bax. These specific interactions result

NAGPA (701 words) [view diff] exact match in snippet view article find links to article

homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma

HBXIP (731 words) [view diff] exact match in snippet view article find links to article

gene. This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is

ASIC4 (593 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

KLRB1 (1,104 words) [view diff] no match in snippet view article find links to article

is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like

DYNLT1 (892 words) [view diff] exact match in snippet view article find links to article

binding identical protein binding cytoskeletal motor activity protein C-terminus binding Cellular component cytoplasm Golgi apparatus secretory vesicle

Maltase-glucoamylase (1,284 words) [view diff] exact match in snippet view article find links to article

similar throughout the N and C-termini. Further studies have found that the C-terminus is composed of 21 more amino acid residues than the N-terminus, which

Hepatitis C virus nonstructural protein 5A (1,179 words) [view diff] no match in snippet view article find links to article

phosphorylated by host cellular protein kinase at the center and near the C terminus, whereas p58 is a form of hyper-phosphorylated NS5A at the center of the

Cav1.3 (3,339 words) [view diff] exact match in snippet view article find links to article

recently been discovered that alternative splicing, particularly in the C-terminus, affects the pharmacological properties of Cav1.3. Strikingly, up to 8-fold

Sortase A (698 words) [view diff] exact match in snippet view article find links to article

is engineered to be at the C-terminus of the protein. A (Gly)n molecule is engineered to contain the label at its C-terminus. Finally, both N and C-termini

FOXN3 (717 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function DNA binding protein C-terminus binding protein binding DNA-binding transcription factor activity sequence-specific DNA

Β-Endorphin (2,766 words) [view diff] exact match in snippet view article find links to article

inwardly-rectifying potassium channel. When a Gβγ or Gα(GTP) molecule binds to the C-terminus of the potassium channel, it becomes active, and potassium ions are pumped

Dishevelled (1,387 words) [view diff] exact match in snippet view article find links to article

(N-terminus) domain, a PDZ (central) domain, a carboxyl-terminal DEP (C-terminus) domain, and two regions with positively charged amino acid residues.

Alexandria Union Station (776 words) [view diff] no match in snippet view article find links to article

Washington, D.C. Terminus Preceding station Southern Railway Following station Seminary toward Birmingham Main Line Washington, D.C. Terminus Preceding station

FPG IleRS zinc finger (738 words) [view diff] no match in snippet view article find links to article

bifunctional base excision repair enzymes. Fpg binds one ion of zinc at the C terminus, which contains four conserved and essential cysteines. Endonuclease VIII

Tensin (720 words) [view diff] exact match in snippet view article find links to article

filaments and contains a phosphotyrosine-binding (PTB) domain at the C-terminus, which interacts with the cytoplasmic tail of β integrins. These interactions

CendR (590 words) [view diff] exact match in snippet view article find links to article

with its receptor only when the second basic residue is exposed at the C-terminus. C-terminal CendR motif engages with widely expressed neuropilin-1 receptors

Uridine monophosphate synthase (3,560 words) [view diff] exact match in snippet view article find links to article

C-terminus in most eukaryotes (e.g., Metazoa, Amoebozoa, Plantae, and Heterolobosea), the inverted fusion, which is to say OPRTase at the C-terminus and

Thiosulfate dehydrogenase (1,519 words) [view diff] no match in snippet view article find links to article

distance of 8.1 Å which assists with rapid electron transfer. Both the N and C terminus domains contain 4 α helices (surrounding the heme in the corresponding

DAPK3 (843 words) [view diff] exact match in snippet view article find links to article

binding protein binding identical protein binding ATP binding protein C-terminus binding Cellular component PML body actin filament membrane raft nucleus

DNM1 (1,472 words) [view diff] exact match in snippet view article find links to article

kinase binding microtubule binding RNA binding GTPase activity protein C-terminus binding D2 dopamine receptor binding protein-containing complex binding

ATP2B2 (977 words) [view diff] exact match in snippet view article find links to article

binding calcium ion binding metal ion binding calmodulin binding protein C-terminus binding protein binding ATP binding hydrolase activity P-type calcium

KCNN1 (668 words) [view diff] exact match in snippet view article find links to article

Zhang BM, Kohli V, Adachi R, et al. (2001). "Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by

KCNN1 (668 words) [view diff] exact match in snippet view article find links to article

Zhang BM, Kohli V, Adachi R, et al. (2001). "Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by

Plant peptide hormone (1,928 words) [view diff] exact match in snippet view article find links to article

leaves. It was found to be an 18-amino acid peptide processed from the C-terminus of a 200-amino acid precursor, which is called prosystemin. CLV3/ESR-related

Desmosome (1,221 words) [view diff] exact match in snippet view article find links to article

needed] The inner dense plaque, also about 15–20 nm in length, contains the C-terminus end of desmoplakin and their attachment to keratin intermediate filaments

Ap180 (403 words) [view diff] exact match in snippet view article find links to article

and lymphoid leukemias where some translocations map to this gene. The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis

X8 protein domain (277 words) [view diff] no match in snippet view article find links to article

The domain is also found in an Olive pollen allergen as well as at the C terminus of family 17 glycosyl hydrolases. Simpson C, Thomas C, Findlay K, Bayer

SCNN1G (3,401 words) [view diff] exact match in snippet view article find links to article

ubiquitin-protein ligase named Nedd4-2. Nedd4-2 ligates ubiquitin to the C-terminus of the ENaC subunit which marks the protein for degradation. At present

PROP1 (957 words) [view diff] exact match in snippet view article find links to article

transcription repressor activity, RNA polymerase II-specific protein C-terminus binding DNA-binding transcription activator activity, RNA polymerase II-specific

Basal cell adhesion molecule (1,272 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function laminin receptor activity protein C-terminus binding protein binding laminin binding transmembrane signaling receptor

C-terminal processing peptidase (255 words) [view diff] exact match in snippet view article find links to article

Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala

ATP1B1 (1,011 words) [view diff] exact match in snippet view article find links to article

sodium:potassium-exchanging transporter activity ATPase activity protein C-terminus binding protein binding MHC class II protein complex binding ATPase activator

Caveolae (1,461 words) [view diff] exact match in snippet view article find links to article

scaffolding domain, long hairpin transmembrane domain and cytoplasmic C-terminus. Caveolins are synthesized as monomers and transported to the Golgi apparatus

HESX1 (1,024 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function sequence-specific DNA binding protein C-terminus binding chromatin binding protein binding protein N-terminus binding DNA-binding

Constitución (Line C Buenos Aires Underground) (134 words) [view diff] no match in snippet view article

Preceding station Buenos Aires Underground Following station San Juan towards Retiro Line C Terminus

Ocular albinism type 1 (2,871 words) [view diff] exact match in snippet view article find links to article

trans-membrane regions but very rarely in the much conserved cytoplasmic C-terminus. Populations belonging to different ethnic groups have been extensively

Scotophilus bat coronavirus 512 (389 words) [view diff] exact match in snippet view article find links to article

spike protein shares similar deletions with group 2 coronaviruses in the C-terminus. Murinae Zoonosis taxonomy. "Taxonomy browser (Scotophilus bat coronavirus

TAS2R10 (1,384 words) [view diff] no match in snippet view article find links to article

GPCR proteins range in size from 25-150 amino acids attached to the C- terminus and can be 80-480 Å in length. In mammals, bitter taste is used as a

AN1 zinc finger (658 words) [view diff] no match in snippet view article find links to article

alpha/beta fold. This domain was first identified as a zinc finger at the C terminus of AN1 SWISSPROT, a ubiquitin-like protein in Xenopus laevis. The AN1-type

Extracellular matrix protein 1 (798 words) [view diff] exact match in snippet view article find links to article

receptor binding signal transducer activity protease binding protein C-terminus binding protein binding enzyme binding laminin binding Cellular component

Glucagon receptor (1,332 words) [view diff] exact match in snippet view article find links to article

Glucagon, the Receptor activity-modifying protein, and the G-protein C-terminus has been determined using a computational and experimental approach. A

SH3 domain (933 words) [view diff] exact match in snippet view article find links to article

chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus). Identifiers Symbol SH3_1 Pfam PF00018 Pfam clan CL0010 ECOD 4.1.1 InterPro

Angiomotin (2,243 words) [view diff] exact match in snippet view article find links to article

coiled-coil domains at N-terminus and consensus PDZ-binding domain at the C-terminus. Angiomotin is expressed predominantly in endothelial cells of capillaries

CD63 (1,581 words) [view diff] exact match in snippet view article find links to article

deletion and point mutants were used to investigate the role of the C-terminus, which contains a putative lysosomal-targeting/internalisation motif (GYEVM)

Synovial sarcoma (1,519 words) [view diff] exact match in snippet view article find links to article

(19 June 2020). "When used together SS18–SSX fusion-specific and SSX C-terminus immunohistochemistry are highly specific and sensitive for the diagnosis

Proteoglycan 4 (3,667 words) [view diff] exact match in snippet view article find links to article

N-terminus of lubricin is associated with its SMB-like domains, whereas the C-terminus is associated with the hemopexin-like domain. Due to the protein's overall

TCF4 (1,156 words) [view diff] exact match in snippet view article find links to article

polymerase II-specific bHLH transcription factor binding E-box binding protein C-terminus binding protein binding identical protein binding TFIIB-class transcription

FXYD2 (957 words) [view diff] exact match in snippet view article find links to article

members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane

Zinc finger (4,882 words) [view diff] exact match in snippet view article find links to article

motif consists of a β-hairpin at the N-terminus and an α-helix at the C-terminus that each contribute two ligands for zinc binding, although a loop and

Prokaryotic ubiquitin-like protein (1,725 words) [view diff] exact match in snippet view article find links to article

from Pup and Ubiquitin, UBact does not contain a di-glycine motif at its C-terminus. Rather, it usually ends with the sequence R[T/S]G[E/Q] (see figure 3)

Adnaviria (1,666 words) [view diff] exact match in snippet view article find links to article

rod-shaped virus 2 (SIRV2). The four-helix bundle is found at the end (C-terminus) of the protein while the beginning (N-terminus) of the protein has an

ASIC2 (991 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

Lactase (2,101 words) [view diff] exact match in snippet view article find links to article

epithelial cells. It is oriented with the N-terminus outside the cell and the C-terminus in the cytosol. LPH contains two catalytic glutamic acid sites. In the

Type IV collagen C4 domain (381 words) [view diff] exact match in snippet view article find links to article

domain (or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens. Each type IV collagen contains a long triple-helical

Cyclic nucleotide-gated channel alpha 3 (971 words) [view diff] exact match in snippet view article find links to article

ion channel activity voltage-gated potassium channel activity protein C-terminus binding intracellular cAMP-activated cation channel activity Cellular

Fusion protein (2,305 words) [view diff] no match in snippet view article find links to article

fragments are typically added to reduce flexibility of either the N or C terminus of the target protein, which reinforces thermostability and stabilizes

ASIC3 (965 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

Syncytin-1 (2,024 words) [view diff] exact match in snippet view article find links to article

ectodomain of ASCT1 and ASCT2, extracellular loop 2 (ECL2), contains at its C-terminus a 21 residue hypervariable region between human, mouse, and hamster receptors

Chemokine receptor (1,559 words) [view diff] exact match in snippet view article find links to article

intracellular and three extracellular hydrophilic loops, and an intracellular C-terminus containing serine and threonine residues that act as phosphorylation sites

Utrophin (1,315 words) [view diff] exact match in snippet view article find links to article

to express dystrophin. The tertiary structure of utrophin contains a C-terminus that consists of protein–protein interaction motifs that interact with

Kir6.2 (1,212 words) [view diff] exact match in snippet view article find links to article

rectifier potassium channel activity ATP binding protein binding protein C-terminus binding heat shock protein binding Cellular component integral component

PFKM (1,932 words) [view diff] exact match in snippet view article find links to article

metal ion binding kinase activity fructose binding kinase binding protein C-terminus binding catalytic activity protein binding identical protein binding phosphofructokinase

KCNJ12 (1,195 words) [view diff] no match in snippet view article find links to article

Art JJ, Nakajima Y, Nakajima S (Jun 2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's

H2AFJ (487 words) [view diff] exact match in snippet view article find links to article

12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. GRCh38: Ensembl release

SNX17 (785 words) [view diff] exact match in snippet view article find links to article

(2001). "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): 1045–50. doi:10

POU3F4 (1,138 words) [view diff] exact match in snippet view article find links to article

in POU3F4 Frameshift truncation and extension mutations at the POU3F4 C-terminus Physical anomalies caused by POU3F4 mutations that have been recognized

N-acetyltransferase (1,638 words) [view diff] exact match in snippet view article find links to article

formation of a Cisplatin adduct with the active-site cysteine residue. The C-terminus helps bind acetyl CoA and differs among NATs including prokaryotic homologues

Cenderitide (1,374 words) [view diff] exact match in snippet view article find links to article

heart failure. Cenderitide is created by the fusion of the 15 amino acid C-terminus of the snake venom dendroaspis natriuretic peptide (DNP) with the full

Munc-18 (806 words) [view diff] exact match in snippet view article find links to article

fusion It has also been shown in one study that Munc-18 binds to the C-terminus of synaptobrevin, suggesting that this protein plays an important role

ELK1 (2,465 words) [view diff] exact match in snippet view article find links to article

encoded by the Fos gene, Elk1 needs to be phosphorylated by MAPKs at its C-terminus. MAPKs are the final effectors of signal transduction pathways that begin

SEMA3F (1,081 words) [view diff] no match in snippet view article find links to article

collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development

KLRD1 (1,386 words) [view diff] no match in snippet view article find links to article

is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence

BAG domain (356 words) [view diff] no match in snippet view article find links to article

four BAG repeats. The BAG domain is a conserved region located at the C terminus of the BAG-family proteins that binds the ATPase domain of Hsc70/Hsp70

Mucin 17 (434 words) [view diff] exact match in snippet view article find links to article

PMID 20926598. Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that

Fimbrial usher protein (436 words) [view diff] exact match in snippet view article find links to article

domain) and two IG-like domains (each about 80 residues long) at the C-terminus (CTD1 and CTD2). Although the degree of sequence similarity of these proteins

Mef2 (1,906 words) [view diff] exact match in snippet view article find links to article

heterodimerize, and a classic nuclear localization sequence (NLS) in the C-terminus of Mef2A, -C, and – D ensures nuclear localization of the protein. D-Mef2

Monte Compatri-Pantano (Rome Metro) (115 words) [view diff] no match in snippet view article

Preceding station Rome Metro Following station Graniti towards San Giovanni Line C Terminus

Junctional adhesion molecule (1,824 words) [view diff] exact match in snippet view article find links to article

protein interaction modules that target short amino acid sequences at the C-terminus of proteins, to form tight junctions in both epithelial and endothelial

SNTG1 (608 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function actin binding protein C-terminus binding structural molecule activity Cellular component cytoplasm ruffle membrane syntrophin

PIAS4 (1,159 words) [view diff] exact match in snippet view article find links to article

ligase binding SUMO transferase activity transferase activity protein C-terminus binding Cellular component cytoplasm PML body nuclear matrix transferase

NEDD8 (2,836 words) [view diff] exact match in snippet view article find links to article

Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochemical and Biophysical Research Communications

Mitosis inducer protein kinase cdr2 (672 words) [view diff] exact match in snippet view article find links to article

sequence characteristic of serine/threonine protein kinase activity. The C-terminus, while non-catalytic, is necessary for proper localization of Cdr2 during

CCL1 (1,363 words) [view diff] exact match in snippet view article find links to article

suppress the apoptotic activity of CCL1, removing three amino acids from the C-terminus of CCL1 reduces CCR8 binding but converts CCL1 to a more potent CCR8 agonist

Glutathione S-transferase (4,293 words) [view diff] exact match in snippet view article find links to article

forms through direct protein–protein interactions between GSTP and the C-terminus of JNK, effectively preventing the action of JNK and thus its induction

FXYD1 (776 words) [view diff] exact match in snippet view article find links to article

members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene

Triosephosphate isomerase (1,178 words) [view diff] exact match in snippet view article find links to article

backbone of each subunit is colored in blue to red from N-terminus to C-terminus. This structural motif is called an αβ-barrel, or a TIM-barrel, and is

Flavodoxin fold (122 words) [view diff] exact match in snippet view article find links to article

chemotactic response in bacteria, PDB accession code 3CHY), which adopts the flavodoxin fold. Ribbon is colored from blue (N-terminus) to red (C-terminus).

Arylomycin (740 words) [view diff] no match in snippet view article find links to article

in the signal peptidase Ala-X-Ala recognition motif. Additionally, the C terminus of the arylomycins is seen to be within hydrogen bonding distance of the

N-type calcium channel (2,070 words) [view diff] exact match in snippet view article find links to article

AJ, Raingo J, Lipscombe D (October 2006). "Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels".

Cleavage and polyadenylation specificity factor (1,898 words) [view diff] no match in snippet view article find links to article

zinc-finger motifs near the N terminus and a CCCH zinc knuckle at the C terminus. Two isoforms of CPSF-30 exist and can be found in CPSF complexes. The

Tyrosine-protein kinase CSK (977 words) [view diff] exact match in snippet view article find links to article

non-membrane spanning protein tyrosine kinase activity metal ion binding protein C-terminus binding protein binding identical protein binding protein tyrosine kinase

Microtubule (7,911 words) [view diff] exact match in snippet view article find links to article

tyrosine from alpha-tubulin. This reaction exposes a glutamate at the new C-terminus. As a result, microtubules that accumulate this modification are often

KCNJ3 (1,129 words) [view diff] no match in snippet view article find links to article

Chen L, Kawano T, Bajic S, et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's

HLA-B (1,889 words) [view diff] case mismatch in snippet view article find links to article

POSITIONING OF THE C-TERMINUS 1a9e: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS 1agb: ANTAGONIST

Tight junction (2,079 words) [view diff] exact match in snippet view article find links to article

consists of four transmembrane domains and both the N-terminus and the C-terminus of the protein are intracellular. It forms two extracellular loops and

TAX1BP3 (726 words) [view diff] exact match in snippet view article find links to article

PMC 3433589. PMID 22876914. Rousset R, Fabre S, Desbois C, et al. (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain

ASIC1 (1,330 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

KCNK3 (1,050 words) [view diff] exact match in snippet view article find links to article

activity protein heterodimerization activity growth factor activity protein C-terminus binding protein binding Cellular component integral component of membrane

KCNJ6 (1,377 words) [view diff] no match in snippet view article find links to article

Kaziro Y, Itoh H, Art JJ, et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's

PIAS1 (1,351 words) [view diff] exact match in snippet view article find links to article

specific binding SUMO transferase activity transferase activity protein C-terminus binding Cellular component PML body nuclear speck nucleoplasm nucleus

TFCP2 (1,486 words) [view diff] exact match in snippet view article find links to article

function DNA-binding transcription factor activity DNA binding protein C-terminus binding protein binding sequence-specific DNA binding DNA-binding transcription

Pestivirus (3,937 words) [view diff] exact match in snippet view article find links to article

a significant amount is secreted into the medium of infected. Erns's C-terminus serves as a membrane anchor, a retention/secretion signal, a binding site

Polycystin 1 (839 words) [view diff] no match in snippet view article find links to article

stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus". The Journal of Clinical Investigation. 114 (10): 1433–43. doi:10.1172/JCI21753

RBCK1 (1,088 words) [view diff] exact match in snippet view article find links to article

ligases, HOIL-1 is able to catalyze oxyester bond formation between the C-terminus of a ubiquitin monomer and Ser/Thr of a different protein. This recently

Pacer (protein) (589 words) [view diff] exact match in snippet view article

regulation of PI3KC3. Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated

Complement component 5 (1,114 words) [view diff] exact match in snippet view article find links to article

streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". Biochem. J. 273 (Pt 3): 635–40. doi:10.1042/bj2730635. PMC 1149811.

Oxaloacetate decarboxylase (1,349 words) [view diff] exact match in snippet view article find links to article

coordination of a Zn2+ metal ion by several residues at the hydrophilic C-terminus. The alpha subunit, which is ~65kDa, is a biotinylated peripheral membrane

SmeT (1,855 words) [view diff] exact match in snippet view article find links to article

the rest of α4, α5, α6, and α7 form the effector binding pocket in the C-terminus. α8 and α9 allow the dimerization of the protein. Hydrophobic interactions

VAMP1 (926 words) [view diff] exact match in snippet view article find links to article

HJ, Dahl R, Petersen TE (November 1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing". Biochemical and Biophysical Research

Collagen, type I, alpha 1 (1,810 words) [view diff] exact match in snippet view article find links to article

acid in the protein strand. Sometimes one end of the gene (called the C-terminus) is altered, which interferes with the association of the protein strands

DYNLL1 (1,545 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function protein domain specific binding protein C-terminus binding protein binding cytoskeletal motor activity cytoskeletal protein

C5a receptor (1,767 words) [view diff] no match in snippet view article find links to article

receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a". Journal of Medicinal Chemistry. 41 (18):

Tropomyosin 3 (888 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 1mv4: TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin 2g9j: Complex of TM1a(1-14)Zip with TM9a(251-284):

Mercury(II) reductase (1,464 words) [view diff] no match in snippet view article

residues (Cys-558' and Cys-559') are found near the surface near the C terminus. The buried cysteine residues function as the site of catalysis whereas

Auxin binding protein (1,593 words) [view diff] no match in snippet view article find links to article

the lumen of the ER correlates with an additional signal located at the C terminus, represented by the sequence Lys-Asp-Glu-Leu, known to be responsible

Rimantadine (1,857 words) [view diff] no match in snippet view article find links to article

ammonium group (with neighboring water molecules) is positioned towards the C terminus with the amantadane group is positioned towards the N-terminus when bound

ERCC4 (3,315 words) [view diff] exact match in snippet view article find links to article

the C terminus of the XPF protein., but residues in the nuclease domain are not present. A DNA binding "helix-hairpin-helix" domain at the C-terminus of

Copine (385 words) [view diff] exact match in snippet view article find links to article

proteins that exhibit a single C2 domain. The core domain located at the C-terminus part of the copine is found to have a unique and conserved primary sequence

Rimantadine (1,857 words) [view diff] no match in snippet view article find links to article

ammonium group (with neighboring water molecules) is positioned towards the C terminus with the amantadane group is positioned towards the N-terminus when bound

Arrestin beta 2 (1,965 words) [view diff] no match in snippet view article find links to article

determined by their intact N domain and the nuclear export signal at the C terminus". The Journal of Biological Chemistry. 278 (13): 11648–53. doi:10.1074/jbc

SLC22A12 (1,080 words) [view diff] no match in snippet view article find links to article

regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus". J. Biol. Chem. 279 (44): 45942–50. doi:10.1074/jbc.M406724200. PMID 15304510

MPDZ (1,136 words) [view diff] exact match in snippet view article find links to article

multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8

Poneratoxin (1,434 words) [view diff] exact match in snippet view article find links to article

are formed by residues 3–9 at the N-terminus, and residues 17–24 at the C-terminus, and they are connected by the beta-turn at residues 11–16. From a three-dimensional

Asparagine endopeptidase (1,932 words) [view diff] exact match in snippet view article find links to article

the LGMN gene (previous symbol PRSC1). It hydrolyzes substrates at the C-terminus of asparagine residues. Discovered in 1996 in beans, its homologues have

Laminin subunit alpha-1 (1,008 words) [view diff] exact match in snippet view article find links to article

binding extracellular matrix structural constituent protein binding protein C-terminus binding glycosphingolipid binding Cellular component extracellular matrix

PPP2CA (1,716 words) [view diff] exact match in snippet view article find links to article

phosphatase activity GABA receptor binding metal ion binding protein C-terminus binding protein binding hydrolase activity protein heterodimerization

Epiplakin (909 words) [view diff] no match in snippet view article find links to article

consists of 13 domains which are all similar to the B domain located at the C terminus of the human epidermal and cardiac muscle protein desmoplakin. The domains

ARR3 (828 words) [view diff] no match in snippet view article find links to article

dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif". J. Biol. Chem. 277 (9): 7356–62. doi:10.1074/jbc

MYO1C (918 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function protein C-terminus binding nucleotide binding actin binding signaling receptor binding cytoskeletal motor activity calmodulin

Sterol regulatory element-binding protein 2 (1,451 words) [view diff] exact match in snippet view article find links to article

repressor activity, RNA polymerase II-specific E-box binding protein C-terminus binding protein binding DNA-binding transcription factor activity, RNA

Dourdan-la-Forêt station (82 words) [view diff] no match in snippet view article find links to article

Preceding station RER Following station Dourdan towards Pontoise, Versailles Château Rive Gauche or Saint-Quentin-en-Yvelines RER C Terminus

Baculoviridae (2,862 words) [view diff] exact match in snippet view article find links to article

oligomerization and fusion domain and a hydrophobic transmembrane domain near the C-terminus (7 aa).[citation needed] It is produced in both early and late phases

Lysine carboxypeptidase (2,161 words) [view diff] exact match in snippet view article find links to article

specifically a carboxypeptidase (sub-subclasses 16-18) which acts on a C-terminus to break off one amino acid. The overall category of metallocarboxypeptidases

Argininosuccinate synthase (1,737 words) [view diff] exact match in snippet view article find links to article

subunits contain a number of salt bridges and hydrogen bonds, and the C-terminus of each subunit is involved in oligomerization by interacting with the

HCN channel (1,568 words) [view diff] exact match in snippet view article find links to article

K+-permeable channels, and a cyclic nucleotide-binding domain (CNBD) in the C-terminus. HCN isoforms are highly conserved in their core transmembrane regions

Soluble guanylyl cyclase (1,169 words) [view diff] exact match in snippet view article find links to article

determined (pdb code 3HLS). The 250-residue guanylate cyclase domain at the C-terminus of sGC is highly conserved in soluble and membrane bound guanylyl cyclases

Tabtoxin (1,045 words) [view diff] no match in snippet view article find links to article

differing by having an extra threonine attached by a peptide bond to the C terminus. Tabtoxin is required by BR2(R) for both chlorosis and lesion formation

DnaQ (1,473 words) [view diff] exact match in snippet view article find links to article

binds the θ subunit and carries out the exonuclease function and the C-terminus binds the α subunit responsible for polymerase activity. A Q-linker peptide

MAP2K1 (1,478 words) [view diff] exact match in snippet view article find links to article

Molecular function protein N-terminus binding kinase activity protein C-terminus binding ATP binding transferase activity protein serine/threonine kinase

YY1 (1,909 words) [view diff] exact match in snippet view article find links to article

transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". Journal of Cellular

TAS2R14 (2,021 words) [view diff] no match in snippet view article find links to article

chimeric Gα16 (type of Gαq), harboring 44 gustducin specific sequence at its C terminus, or Gαqi5, a Gαq protein containing the five carboxyl-terminal amino acids

Homeobox protein NANOG (2,462 words) [view diff] exact match in snippet view article find links to article

of hNanog is rich in serine, threonine and proline residues, and the C-terminus contains a tryptophan-rich domain. The homeodomain in hNANOG ranges from

Secretion (2,981 words) [view diff] exact match in snippet view article find links to article

use this pathway have the capability to form a beta-barrel with their C-terminus which inserts into the outer membrane, allowing the rest of the peptide

SNTB1 (1,034 words) [view diff] exact match in snippet view article find links to article

Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (Mar 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain

ID1 (1,953 words) [view diff] exact match in snippet view article find links to article

DNA-binding transcription factor activity protein self-association protein C-terminus binding protein binding DNA-binding transcription factor activity, RNA

P2X purinoreceptor (2,639 words) [view diff] no match in snippet view article find links to article

through specific members of the SNARE protein family. A YXXXK motif in the C terminus is common to all P2X subunits and seems to be important for trafficking

Beta-2 microglobulin (2,118 words) [view diff] case mismatch in snippet view article find links to article

POSITIONING OF THE C-TERMINUS 1a9e: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS 1agb: ANTAGONIST

Butyrylcholinesterase (2,228 words) [view diff] exact match in snippet view article find links to article

Altamirano CV, Lockridge O (October 1999). "Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers".

SMG6 (1,738 words) [view diff] exact match in snippet view article find links to article

17. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a PilT N-terminus (PIN) domain. This structure

Nebulette (919 words) [view diff] exact match in snippet view article find links to article

N-terminus, and a serine-rich region adjacent to an SH3 domain at its C-terminus. Though nebulette shares structural features with nebulin, nebulin is

MSMB (2,098 words) [view diff] exact match in snippet view article find links to article

remarkable similarity despite having only 51% of amino acids in common. The C-terminus domain of MSMB contains two two-stranded β-sheets; these have no resemblance

L-gulonolactone oxidase (2,432 words) [view diff] exact match in snippet view article find links to article

helices that make up the structure of L-gulonolactone oxidase. Lime green is showing the N-terminus. Red is displaying the C-terminus end of the protein.

Ubiquitin carboxy-terminal hydrolase L1 (2,637 words) [view diff] exact match in snippet view article find links to article

H, Kito K, Caskey LS, Yeh ET, Kamitani T (Oct 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochemical and Biophysical Research Communications

Peptidoglycan binding domain (674 words) [view diff] no match in snippet view article find links to article

three-helical bundle with a left-handed twist. It is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. Examples

Kisspeptin (3,317 words) [view diff] exact match in snippet view article find links to article

RFamides which all share a common arginine-phenylalanine-NH2 motif at their C-terminus. Among these conserved amino acids are arginine and phenylalanine residues

Myosin light-chain kinase (1,731 words) [view diff] case mismatch in snippet view article find links to article

binding to myosin light chain. This myosin binding domain is located at the C-Terminus end of the kinase. On the other side of the kinase at the N-Terminus end

Von Willebrand factor (1,998 words) [view diff] exact match in snippet view article find links to article

shear flow, calcium binding, and a "vicinal disulfide" at the A2-domain’s C-terminus. The A3 domain: Acts as the primary collagen binding site for VWF, binding

Insect olfactory receptor (548 words) [view diff] exact match in snippet view article find links to article

reversed topology, with an intracellular N-terminus and an extracellular C-terminus. Differently to mammalian ORs, insect ORs form a heteromer with a fixed

Melanin-concentrating hormone receptor 1 (2,033 words) [view diff] exact match in snippet view article find links to article

activity neuropeptide receptor activity signaling receptor binding protein C-terminus binding hormone binding neuropeptide binding peptide binding Cellular

CDKN2B (1,386 words) [view diff] exact match in snippet view article find links to article

proteins that share the N-terminal sequence but completely differ in the C-terminus. CDKN2B tumor suppressor gene product p15 has been shown to interact with

P2RX7 (3,366 words) [view diff] no match in snippet view article find links to article

proteins induce membrane blebbing and interact with the P2X7 receptor C terminus". The Journal of Biological Chemistry. 277 (37): 34017–23. doi:10.1074/jbc

5-HT3 receptor (2,395 words) [view diff] exact match in snippet view article find links to article

involved in receptor trafficking and regulation; and a short extracellular C-terminus (Fig.1). Whereas extracellular domain is the site of action of agonists

Latrotoxin (2,273 words) [view diff] exact match in snippet view article find links to article

and activate the α-LTX precursor molecules by means of hydrolysis. The C-terminus too is recognized by these furin-like proteases and is also cleaved. α-LTX

Ligand-gated ion channel (2,607 words) [view diff] no match in snippet view article find links to article

final half of the LBD and then finishing with helix 4 of the TMD at the C terminus. This means there are three links between the TMD and the extracellular

Ficain (1,346 words) [view diff] exact match in snippet view article find links to article

structure of ficain from Ficus carica, rainbow colored, N-terminus blue, C-terminus red. Identifiers EC no. 3.4.22.3 CAS no. 9001-33-6 Databases IntEnz IntEnz

DAX1 (1,842 words) [view diff] exact match in snippet view article find links to article

Murashita M, Mukai T, Imanaka K, Fujieda K (Oct 1996). "Truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked

Landover station (607 words) [view diff] no match in snippet view article find links to article

Preceding station Pennsylvania Railroad Following station Washington, D.C. Terminus Philadelphia, Wilmington and Baltimore Railroad Lanham toward Philadelphia

Coronin (1,757 words) [view diff] exact match in snippet view article find links to article

N-terminus and ending with a tryptophane-aspartic acid (WD) dipeptide at the C-terminus. The WD domain has no intrinsic catalytic activity and is thought to serve

Transmembrane protein 217 (1,089 words) [view diff] exact match in snippet view article find links to article

alpha helices. The N-terminus and C-terminus of the protein are predicted to be facing the cytosol with the C-terminus containing a long predicted coiled

Thermostability (2,222 words) [view diff] exact match in snippet view article find links to article

protein. Cyclizing enzymes by covalently linking the N-terminus to the C-terminus has been applied to increase the thermostability of many enzymes. Intein

Zuotin (338 words) [view diff] exact match in snippet view article find links to article

"neck" of RAC. The four-helix-bundle RAC head domain is located at the C-terminus and binds the small (40S) subunit. The J domain-Ssz1p complex, located

Alanine racemase (1,390 words) [view diff] no match in snippet view article find links to article

covalently linked via an aldimine linkage to a lysine residue, which is at the C terminus of the first beta-strand of the alpha/beta barrel. Reaction mechanisms

Metabotropic glutamate receptor 1 (2,342 words) [view diff] no match in snippet view article find links to article

Robbins MJ, Willis AC, McIlhinney RA (January 1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins:

Transmissible gastroenteritis virus (1,145 words) [view diff] exact match in snippet view article find links to article

domains within the E2 protein. A 20 residue hydrophobic segment at the C-terminus anchors the protein in the lipid membrane. The rest of the protein is

Dystonin (1,478 words) [view diff] exact match in snippet view article find links to article

microtubule plus-end binding metal ion binding integrin binding protein C-terminus binding protein binding actin binding microtubule binding structural molecule

CTGF (1,537 words) [view diff] exact match in snippet view article find links to article

function fibronectin binding insulin-like growth factor binding protein C-terminus binding protein binding growth factor activity integrin binding heparin

EP300 (4,193 words) [view diff] no match in snippet view article find links to article

"Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4". J. Biol. Chem. 278 (6):

Leguminous lectin family (526 words) [view diff] no match in snippet view article find links to article

terminus of mature conA thus corresponds to that of the alpha chain and the C terminus to the beta chain. Sharon N, Lis H (1990). "Legume lectins--a large family

Pemphigoid (5,868 words) [view diff] exact match in snippet view article find links to article

skin. The major basement membrane zone proteins identified include : C-terminus of BP180 BP230 Laminin 332(also known as laminin 5 or epiligrin) Alpha-6-beta-4