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searching for C-terminus 319 found (1634 total)

alternate case: c-terminus

Pax genes (1,191 words) [view diff] exact match in snippet view article find links to article

and PAX7), a complete homeodomain to the C-terminus. An octapeptide as well as a Pro-Ser-Thr-rich C terminus may also be present. Pax proteins are important

Benign familial neonatal seizures (2,580 words) [view diff] exact match in snippet view article find links to article

1, primarily located in the voltage sensitive S4 segment through the C-terminus. Of these mutations, 5 are nonsense mutations, 13 are missense mutations

GPR87 (297 words) [view diff] no match in snippet view article find links to article

extracellular N terminus, 7 transmembrane regions, and an intracellular C terminus.[supplied by OMIM] GRCh38: Ensembl release 89: ENSG00000138271 – Ensembl

D-alanine—D-alanine ligase (338 words) [view diff] exact match in snippet view article find links to article

D-alanine—D-alanine ligase is thought to be involved in substrate binding, while the C-terminus is thought to be a catalytic domain. As of late 2007, 8 structures have

Carboxypeptidase B (264 words) [view diff] exact match in snippet view article find links to article

preferentially cleaves off basic amino acids arginine and lysine from the C-terminus of a peptide. This enzyme is secreted by the pancreas, and it travels

Type XVIII collagen (753 words) [view diff] no match in snippet view article find links to article

collagen which can be cleaved to form endostatin. The endostatin is from the c terminus end of the collagen XVIII, and is known to have an inhibitory effect on

Signal peptide (1,777 words) [view diff] exact match in snippet view article find links to article

long) present at the N-terminus (or occasionally nonclassically at the C-terminus or internally) of most newly synthesized proteins that are destined toward

Periplakin (1,064 words) [view diff] exact match in snippet view article find links to article

N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein

BACH2 (995 words) [view diff] exact match in snippet view article find links to article

N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus. GRCh38: Ensembl release 89: ENSG00000112182 – Ensembl, May 2017 GRCm38:

TOX3 (767 words) [view diff] exact match in snippet view article find links to article

structure by unwinding and bending DNA. The protein TOX3 has a glutamine-rich C-terminus due to CAG repeats. TOX3 is located on human chromosome band 16q12.1.

Pancreatic lipase family (1,730 words) [view diff] no match in snippet view article find links to article

toward the N terminus is an α/β hydrolase, whereas the one toward the C terminus plays a role in binding to colipase, a protein needed in order for the

Cyanogen bromide (1,486 words) [view diff] exact match in snippet view article find links to article

used to modify biopolymers, fragment proteins and peptides (cuts the C-terminus of methionine), and synthesize other compounds. The compound is classified

P73 (1,132 words) [view diff] exact match in snippet view article find links to article

differing at either at the C- or the N-terminus. Currently, six different C-terminus splicing variants have been found in normal cells. The p73 gene encodes

TRPC (1,184 words) [view diff] exact match in snippet view article find links to article

TRP box motif containing the invariant EWKFAR sequence at the proximal C-terminus. These channels are non-selectively permeable to cations, with a prevalence

Congenital stationary night blindness (2,878 words) [view diff] exact match in snippet view article find links to article

LRRs (LRR1-11) flanked by cysteine-rich LRRs (LRRNT and LRRCT). At the C-terminus of the protein there is a putative GPI anchor site. Although the function

Protein tag (2,683 words) [view diff] exact match in snippet view article find links to article

end of the target protein, so they are either C-terminus or N-terminus specific or are both C-terminus and N-terminus specific. Some tags are also inserted

Neuromedin N (521 words) [view diff] exact match in snippet view article find links to article

whose sequences are found on the pro neurotensin/neuromedin N precursor C-terminus. Both sequences of neuromedin N as well as neurotensin are flanked by

MAP3K4 (1,109 words) [view diff] no match in snippet view article find links to article

MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression

Generalized epilepsy with febrile seizures plus (3,419 words) [view diff] case mismatch in snippet view article find links to article

1807delMFYE C-Terminus F1808L C-Terminus Yes Hyperexcitable W1812G C-Terminus F1831S C-Terminus M1841T C-Terminus S1846fsX1856 C-Terminus R1882X C-Terminus D1886Y

EPI-001 (1,307 words) [view diff] exact match in snippet view article find links to article

the anitens novel molecular mechanism from anti androgens that bind the C-terminus ligand-binding domain and have the stem class "lutamide" (such as flutamide

NFKB2 (1,276 words) [view diff] exact match in snippet view article find links to article

hereditary endocrine and immuneodeficiences. The mutation occurs at the C-terminus of NFKB2 and it causes common variable immunodeficienciency which in turn

Integrase (1,288 words) [view diff] exact match in snippet view article find links to article

protein consisting of three domains- N-terminus, catalytic core domain, and C-terminus, which each have distinct properties and functions contributing to the

Hefutoxin (276 words) [view diff] exact match in snippet view article find links to article

an amidated C terminus and is the shortest scorpion toxin reported so far. The κ- hefutoxin2 is built up of 23 residues with free C-terminus. The toxin

SYT1 (1,503 words) [view diff] no match in snippet view article find links to article

2010. Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (Mar 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to

Versican (2,427 words) [view diff] no match in snippet view article find links to article

Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene. Versican is a large

DnaC (1,405 words) [view diff] exact match in snippet view article find links to article

prokaryotic loading factor found in Escherichia coli that complexes with the C-terminus of helicase dnaB during the initial stages of prokaryotic DNA replication

Claudin (1,301 words) [view diff] exact match in snippet view article find links to article

epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudins are small (20–24/27 kilodalton (kDa)) transmembrane

GRIN1 (1,306 words) [view diff] exact match in snippet view article find links to article

alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing

FLAG-tag (846 words) [view diff] exact match in snippet view article find links to article

blotting. The peptide sequence of the FLAG-tag from the N-terminus to the C-terminus is: DYKDDDDK (1012 Da). Additionally, FLAG-tags may be used in tandem

Integral membrane protein (1,144 words) [view diff] no match in snippet view article find links to article

have the N terminus on the far side and C terminus on the cytosolic side. Group II proteins have the C terminus on the far side and N terminus in the cytosol

Orange carotenoid N-terminal domain (531 words) [view diff] no match in snippet view article find links to article

residues from the N-terminus and approximately 150 residues from the C terminus. This domain is implicated in binding the phycobilisome complex, which

SNX6 (221 words) [view diff] no match in snippet view article find links to article

the retromer complex. The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation

Phosphofructokinase 2 (4,253 words) [view diff] exact match in snippet view article find links to article

activated which phosphorylates either Serine 466 or Serine 483 in the C-terminus. Alternatively, Protein Kinase B may also phosphorylate these regulatory

Cupiennin (740 words) [view diff] exact match in snippet view article find links to article

are characterised by a more hydrophobic N-terminal chain region and a C-terminus composed preferentially of polar and charged residues. Their distinguishing

Beta sheet (3,137 words) [view diff] exact match in snippet view article find links to article

C-terminus, β-strands too can be said to be directional. They are usually represented in protein topology diagrams by an arrow pointing toward the C-terminus

Lens fiber major intrinsic protein (860 words) [view diff] exact match in snippet view article find links to article

PMID 1505237. Girsch SJ, Peracchia C (1992). "Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26". Curr. Eye Res. 10 (9):

GIPC1 (1,893 words) [view diff] exact match in snippet view article find links to article

the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling. GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS

Tropomodulin (1,575 words) [view diff] exact match in snippet view article find links to article

N-terminus half and a C-Terminus half. The N-terminus half is seen to be mostly extended, unstructured, and flexible and the C-terminus half is seen to be

ADF/Cofilin family (1,915 words) [view diff] no match in snippet view article find links to article

and includes the central alpha helix, the N-terminus extension, and the C terminus helix. The N-terminus extension consists of a tilted loop that facilitates

Mutant protein (128 words) [view diff] exact match in snippet view article find links to article

leading to disease) or wide-range amino acid changes by e.g. truncation of C-terminus after introducing premature stop codon. Site-directed mutagenesis Phi

BRCT domain (276 words) [view diff] no match in snippet view article find links to article

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that

Substance P (5,300 words) [view diff] exact match in snippet view article find links to article

Gln Gln Phe Phe Gly Leu Met (RPKPQQFFGLM) with an amide group at the C-terminus. Substance P is released from the terminals of specific sensory nerves

DNA polymerase (7,106 words) [view diff] exact match in snippet view article find links to article

C-terminus "polymerase relic" region, despite being unnecessary for polymerase activity, is thought to be essential to cell vitality. The C-terminus region

M protein (Streptococcus) (1,652 words) [view diff] exact match in snippet view article

molecule is the M protein produced by certain streptococcal bacteria. At its C-terminus within the cell wall, M proteins embody a motif that is now known to be

Holin (1,253 words) [view diff] exact match in snippet view article find links to article

transmembrane domains (TMDs) with the N-terminus in the periplasm and the C-terminus in the cytoplasm. They generally have over 95 residues. Examples of class

HIV-1 protease (2,369 words) [view diff] exact match in snippet view article find links to article

PR. PR is located between the reverse transcriptase (which is at the C-terminus of PR) and the p6pol (which is at the N-terminus of PR) of the transframe

ATM serine/threonine kinase (5,695 words) [view diff] exact match in snippet view article find links to article

repeats directly bind to the C-terminus of NBS1. The FAT domain interacts with ATM's kinase domain to stabilize the C-terminus region of ATM itself. The

Ferredoxin fold (81 words) [view diff] exact match in snippet view article find links to article

which adopts a ferredoxin fold with an extra β-strand at the C-terminus (shown in red). The ribbon is colored from blue (N-terminus) to red (C-terminus).

Glutamate decarboxylase (4,776 words) [view diff] no match in snippet view article find links to article

This interaction occurs at the 30-50bp CAM-binding domain (CaMBD) in its C terminus and is necessary for proper regulation of GABA production. Unlike vertebrates

Coronavirus envelope protein (1,897 words) [view diff] exact match in snippet view article find links to article

The balance of evidence suggests the most common orientation has the C-terminus oriented toward the cytoplasm. Studies of SARS-CoV-2 E protein are consistent

Transmembrane protein (2,278 words) [view diff] no match in snippet view article find links to article

have the N terminus on the far side and C terminus on the cytosolic side. Group II proteins have the C terminus on the far side and N terminus in the cytosol

Ubiquitin D (2,244 words) [view diff] exact match in snippet view article find links to article

an ATP-dependent ubiquitin activating enzyme. The carboxyl terminal (C-terminus) of ubiquitin is linked to the cysteine residue of the E1 protein by a

Interleukin 15 (4,458 words) [view diff] exact match in snippet view article find links to article

a 316 bp 5'-untranslated region (UTR), 486 bp coding sequence and the C-terminus 400 bp 3'-UTR region. The other isoform (IL-15 SSP) has a short signal

Pol (HIV) (157 words) [view diff] exact match in snippet view article

The Gag-Pol region containing the protease gene flanked by p6pol at the N-terminus and reverse transcriptase at the C-terminus.

Tyrocidine (1,351 words) [view diff] exact match in snippet view article find links to article

a head-to-tail fashion involving the N-terminus of the D-Phe1 and the C-terminus of the L-Leu10 (See figure 4). There is no general biochemical solution

Delta atracotoxin (2,268 words) [view diff] exact match in snippet view article find links to article

and Tyr25, and is flanked by Ile21 at its N-terminus and Trp7 near its C-terminus, so this region represents a significant non-polar surface on the molecule

Phage display (4,630 words) [view diff] exact match in snippet view article find links to article

by adding an 8-10 amino acid linker between the cDNA and pIII at the C-terminus. pVIII is the main coat protein of Ff phages. Peptides are usually fused

Epiregulin (1,149 words) [view diff] exact match in snippet view article find links to article

homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands

Phospholipase C (2,691 words) [view diff] exact match in snippet view article find links to article

N-terminus. Alpha-toxin has an additional 120 residues in the C-terminus. The C-terminus of the alpha-toxin has been reported as a "C2-like" domain, referencing

ATP2A2 (228 words) [view diff] exact match in snippet view article find links to article

hydrolase activity ATP binding P-type calcium transporter activity protein C-terminus binding lutropin-choriogonadotropic hormone receptor binding P-type proton-exporting

COPG2 (1,032 words) [view diff] exact match in snippet view article find links to article

"Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77–85. doi:10.1078/0171-9335-00222. PMID 11893085

NOBOX (2,190 words) [view diff] no match in snippet view article find links to article

encoded by 8 exons. It has a proline rich C terminus and contains putative SH3 and WW domains. This C terminus is believed to be critical in its transcriptional

Muscarinic toxin 7 (214 words) [view diff] no match in snippet view article find links to article

rendered with BIOVA Discovery Visual Studio. Muscarinic Toxin 7 (yellow ribbon) bound to the Muscarinic M1 receptor (Red -> Blue indicates N -> C terminus)

Essential thrombocythemia (2,154 words) [view diff] no match in snippet view article find links to article

that cause a reading shift, which then leads to the formation of a novel C terminus. There are two common types of CALR mutations, type 1 and type 2. Type

Glucagon-like peptide-1 receptor (4,085 words) [view diff] exact match in snippet view article find links to article

domains (TM1-TM7), an extracellular N-terminus, and an intracellular C-terminus. It belongs to the class B family of G protein-coupled receptors, also

Α-Amylase (2,302 words) [view diff] no match in snippet view article find links to article

C terminus. This domain is organised as a five-stranded antiparallel β-sheet. Several α-amylases contain an all-β domain, usually at the C terminus.

COPG (997 words) [view diff] exact match in snippet view article find links to article

"Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2). Germany: 77–85. doi:10.1078/0171-9335-00222

L-type calcium channel (2,004 words) [view diff] exact match in snippet view article find links to article

EF-hand motifs on the N-terminus. Both the N and C terminus are in the cytosolic space with the C-terminus being much longer than the N-terminus. The β subunit

Autochaperone (146 words) [view diff] no match in snippet view article find links to article

domain. When the passenger domain is translocated, starting with its C terminus, the autochaperone domain is first out. This would result in the formation

UBE2D3 (1,253 words) [view diff] exact match in snippet view article find links to article

Wang X, Shi Y, Wang J, Huang G, Jiang X (Sep 2008). "Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation"

CENPF (1,346 words) [view diff] no match in snippet view article find links to article

1006/bbrc.1995.1959. PMID 7612011. Zhu X, Chang KH, He D, et al. (1995). "The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore

Cholecystokinin (3,029 words) [view diff] exact match in snippet view article find links to article

resides in the C-terminus of the peptide. Most CCK peptides have a sulfate group attached to a tyrosine located seven residues from the C-terminus (see tyrosine

RHEB (2,661 words) [view diff] exact match in snippet view article find links to article

hypervariable region ending at the C-terminus in a CAAX motif (C – cysteine, A – aliphatic amino acid, X – C-terminus amino acid). The protein is a lipid-anchored

KLK6 (1,866 words) [view diff] no match in snippet view article find links to article

Arg is towards the N terminus and a general amino acid is towards the C terminus. It is believed to follow a similar pathway to other serine-type proteases

Group-specific antigen (1,572 words) [view diff] exact match in snippet view article find links to article

needed] The p24 capsid protein (CA) is a 24 kDa protein fused to the C-terminus of MA in the unprocessed HIV Gag polyprotein. After viral maturation,

EIF3M (597 words) [view diff] no match in snippet view article find links to article

1038/msb4100134. PMC 1847948. PMID 17353931. Perez-Romero P, Fuller AO (2005). "The C terminus of the B5 receptor for herpes simplex virus contains a functional region

GOPC (1,213 words) [view diff] no match in snippet view article find links to article

PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM] GOPC has

Physalaemin (546 words) [view diff] case mismatch in snippet view article find links to article

membrane, PHY takes on a helical confirmation from the Pro4 residue to the C-Terminus. This helical conformation is essential to allow the binding of PHY to

Ku (protein) (1,709 words) [view diff] exact match in snippet view article

the opposite subunit. In some cases a fourth domain is present at the C-terminus, which binds to DNA-dependent protein kinase catalytic subunit. Both subunits

Glutamine synthetase (3,036 words) [view diff] exact match in snippet view article find links to article

rings of GS together. Each subunit possesses a C-terminus and an N-terminus in its sequence. The C-terminus (helical thong) stabilizes the GS structure by

Ras GTPase (4,042 words) [view diff] exact match in snippet view article find links to article

Tripeptide (aaX) is then cleaved from the C-terminus by a specific prenyl-protein specific endoprotease and the new C-terminus is methylated by a methyltransferase

TRPP (427 words) [view diff] exact match in snippet view article find links to article

All of the members of this group contain a coiled coil region in their C-terminus involved in the interaction with the polycystin-1 group. TRPP1 and TRPP3

WDTC1 (347 words) [view diff] exact match in snippet view article find links to article

protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus. Reduced expression or disruption of WDTC1 gene is associated with obesity

STUB1 (1,481 words) [view diff] no match in snippet view article find links to article

containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). The CHIP protein encoded by this gene binds

Cadherin cytoplasmic region (200 words) [view diff] exact match in snippet view article find links to article

biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding

ABCA1 (2,084 words) [view diff] exact match in snippet view article find links to article

relatively unknown, there has been some determination of the c-terminus. The ABCA1 c-terminus contains a PDZ domain, responsible for mediating protein-protein

Beta-propeller (2,034 words) [view diff] exact match in snippet view article find links to article

attributed to increased hydrophobic interactions due to mutations at the C-terminus of the beta-propeller. The beta-propeller domain of the influenza virus

Ginger milk curd (417 words) [view diff] exact match in snippet view article find links to article

occurs, the ginger protease cuts open the κ-casein so that the hydrophilic C-terminus and the hydrophobic N-terminus separate. This disrupts the stability of

Peptide YY (2,673 words) [view diff] exact match in snippet view article find links to article

and Y5 receptors. It is thought that the Y1 receptor requires both the C-terminus and N-terminus for recognition, binding and then subsequent activation

Hypomagnesemia with secondary hypocalcemia (1,033 words) [view diff] exact match in snippet view article find links to article

Q1260fsX1283 C-terminus , c.del Ex 25 - 27 C-terminus c.del Ex 26 Y1533X C-terminus No c.5017-18delT L1673fsX1675 C-terminus No c.del Ex 31 + 32 C-terminus No c

Occludin (2,898 words) [view diff] exact match in snippet view article find links to article

extracellular domain 2 (48 aa) transmembrane domain 4 (22 aa) C-terminus domain (257 aa) The C-terminus domain has been shown experimentally to be required for

Glia maturation factor (115 words) [view diff] exact match in snippet view article find links to article

diagram of the crystal structure of GMFG. Spectral coloring is from blue (N-terminus) to red (C-terminus). Secondary structural elements are indicated

Carboxypeptidase (816 words) [view diff] exact match in snippet view article find links to article

containing the sequence -Pro-Xaa (Pro is proline, Xaa is any amino acid on the C-terminus of a peptide) is called "prolyl carboxypeptidase". Some, but not all,

SYT13 (503 words) [view diff] no match in snippet view article find links to article

extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include

Carboxypeptidase (816 words) [view diff] exact match in snippet view article find links to article

containing the sequence -Pro-Xaa (Pro is proline, Xaa is any amino acid on the C-terminus of a peptide) is called "prolyl carboxypeptidase". Some, but not all,

SYT13 (503 words) [view diff] no match in snippet view article find links to article

extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include

Glucagon-like peptide-2 receptor (812 words) [view diff] no match in snippet view article find links to article

Yusta B, Drucker DJ (Jun 2005). "The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced

Metabotropic receptor (670 words) [view diff] no match in snippet view article find links to article

terminus is located on the extracellular side of the membrane and its C terminus is on the intracellular side. The 7 transmembrane spanning domains, with

Interferon-alpha/beta receptor (2,617 words) [view diff] exact match in snippet view article find links to article

degron, preventing its internalization. Following receptor agonism, the C-terminus of IFNAR is phosphorylated, followed by its ubiquitination and internalization

Exosortase (399 words) [view diff] exact match in snippet view article find links to article

sortases. Archaeosortase A recognizes the signal PGF-CTERM, found at the C-terminus of some archaeal S-layer proteins. Following processing by archaeosortase

HIC2 (577 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function DNA binding protein C-terminus binding metal ion binding nucleic acid binding DNA-binding transcription factor activity

PDLIM5 (1,032 words) [view diff] no match in snippet view article find links to article

100-amino acid PDZ domain in the N-terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found

LOXL4 (660 words) [view diff] exact match in snippet view article find links to article

collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that

S-tag (216 words) [view diff] exact match in snippet view article find links to article

distinct structure. On DNA-level the S-tag can be attached to the N- or C-terminus of any protein. After gene expression, such a tagged protein can be detected

KSR1 (553 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function metal ion binding protein C-terminus binding protein binding ATP binding MAP-kinase scaffold activity protein kinase activity

GIPC3 (860 words) [view diff] no match in snippet view article find links to article

the GIPC3 gene. GIPC3 is a member of the GIPC (GAIP-interacting protein C terminus) gene family that also includes GIPC1 and GIPC2. The encoded protein,

NHL repeat (461 words) [view diff] exact match in snippet view article find links to article

type II, ascorbate-dependent monooxygenase family which catalyse the C-terminus alpha-amidation of biological peptides. In many it occurs in tandem arrays

EIF2A (1,000 words) [view diff] no match in snippet view article find links to article

Weiser DC, Sikes S, Li S, Shenolikar S (Nov 2004). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional

Rhinolophus bat coronavirus HKU2 (267 words) [view diff] exact match in snippet view article find links to article

spike protein shares similar deletions with group 2 coronaviruses in the C-terminus. Murinae Zoonosis Lau, SK; Woo, PC; Li, KS; Huang, Y; Wang, M; Lam, CS;

TATA-binding protein (3,218 words) [view diff] exact match in snippet view article find links to article

of the protein. This region modulates the DNA binding activity of the C-terminus, and modulation of DNA-binding affects the rate of transcription complex

SYT3 (679 words) [view diff] no match in snippet view article find links to article

PMID 10531343. Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to

Glypican 2 (865 words) [view diff] exact match in snippet view article find links to article

gene is at locus 7q22.1 and encodes for a 579 amino acid protein. The C-terminus of GPC2 has the GPI attachment site, at G554, and the N-terminus encodes

KKXX (amino acid sequence) (311 words) [view diff] no match in snippet view article

KKXX and for some proteins XKXX is a target peptide motif located in the C terminus in the amino acid structure of a protein responsible for retrieval of

Transcription factor Sp1 (3,441 words) [view diff] exact match in snippet view article find links to article

trans-activation. SP1 most notably contains three zinc finger protein motifs at its C-terminus, by which it binds directly to DNA and allows for interaction of the protein

PIP5K1C (842 words) [view diff] exact match in snippet view article find links to article

focal adhesion plaques, and binds the FERM domain of talin through its C-terminus. GRCh38: Ensembl release 89: ENSG00000186111 – Ensembl, May 2017 GRCm38:

Terminus (play) (197 words) [view diff] no match in snippet view article

daughter (B), and a serial killer who has sold his soul to the Devil (C). Terminus premiered at the Abbey Theatre in Dublin on 9 June 2007, before transferring

Rab (G-protein) (1,327 words) [view diff] exact match in snippet view article

Specifically, Rabs are anchored via prenyl groups on two cysteines in the C-terminus. Rab escort proteins (REPs) deliver newly synthesized and prenylated Rab

Nociceptin receptor (3,363 words) [view diff] no match in snippet view article find links to article

the nociceptin receptor by alanine substitution of glutamine 286 at the C terminus of transmembrane segment VI: evidence from a site-directed mutagenesis

Insulin receptor substrate 1 (4,304 words) [view diff] exact match in snippet view article find links to article

domain ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail. Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous

SCNN1B (3,035 words) [view diff] exact match in snippet view article find links to article

ubiquitin-protein ligase named Nedd4-2. Nedd4-2 ligates ubiquitin to the C-terminus of the ENaC subunit which marks the protein for degradation. At present

Alpha helix (5,204 words) [view diff] exact match in snippet view article find links to article

clear that all the backbone carbonyl oxygens point downward (toward the C-terminus) but splay out slightly, and the H-bonds are approximately parallel to

TOP3B (743 words) [view diff] exact match in snippet view article find links to article

aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct

TRIM27 (1,049 words) [view diff] exact match in snippet view article find links to article

germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the

Glycolipid (1,596 words) [view diff] exact match in snippet view article find links to article

lipid moiety bound to a carbohydrate complex. They can be bound to the C-terminus of a protein and have various functions associated with the different

INPP5B (627 words) [view diff] exact match in snippet view article find links to article

associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been

Pertactin (430 words) [view diff] exact match in snippet view article find links to article

is region 2 (R2) which contains Pro-Gln-Pro (PQP) repeats towards the C-terminus. This protein’s contribution to immunity is still premature. Reports suggest

Cav1.3 (3,339 words) [view diff] exact match in snippet view article find links to article

recently been discovered that alternative splicing, particularly in the C-terminus, affects the pharmacological properties of Cav1.3. Strikingly, up to 8-fold

LOXL3 (661 words) [view diff] exact match in snippet view article find links to article

collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that

Hepatitis C virus nonstructural protein 5A (1,179 words) [view diff] no match in snippet view article find links to article

phosphorylated by host cellular protein kinase at the center and near the C terminus, whereas p58 is a form of hyper-phosphorylated NS5A at the center of the

BAG2 (720 words) [view diff] no match in snippet view article find links to article

BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein

DYNLT1 (892 words) [view diff] exact match in snippet view article find links to article

binding identical protein binding cytoskeletal motor activity protein C-terminus binding Cellular component cytoplasm Golgi apparatus secretory vesicle

ASIC4 (593 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

FOXN3 (717 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function DNA binding protein C-terminus binding protein binding DNA-binding transcription factor activity sequence-specific DNA

KLRB1 (1,104 words) [view diff] no match in snippet view article find links to article

is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like

BAG5 (581 words) [view diff] exact match in snippet view article find links to article

shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three

KLRC2 (1,230 words) [view diff] no match in snippet view article find links to article

proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family

Ku70 (2,195 words) [view diff] exact match in snippet view article find links to article

Bax-dependent apoptosis. Interactions between Ku70 and Bax occurs in the C-terminus of Ku70 and the N-terminus of Bax. These specific interactions result

Rubicon homology domain (444 words) [view diff] exact match in snippet view article find links to article

and form at least 4 zinc finger motifs. Amino acid residues toward the C-terminus of the RH domain of Rubicon have been shown to be essential for interaction

Cysteine-rich protein (757 words) [view diff] exact match in snippet view article find links to article

secretion peptide signal at the N-terminus and a cysteine-rich region at the C-terminus. In an oxidising environment cysteines cross-link to form disulphide bonds

Alexandria Union Station (777 words) [view diff] no match in snippet view article find links to article

Washington, D.C. Terminus Preceding station Southern Railway Following station Seminary toward Birmingham Main Line Washington, D.C. Terminus Preceding station

Methyl-CpG-binding domain (570 words) [view diff] no match in snippet view article find links to article

by another layer formed by the alpha1 helix and a hairpin loop at the C terminus. These layers are both amphipathic, with the alpha1 helix and the beta

Limulus clotting factor C (394 words) [view diff] exact match in snippet view article find links to article

initiating a cascade leading to coagulin formation. From the N-terminus to the C-terminus, the domains are: EGF-like domain 3 Sushi domains one LCCL domain and

Uridine monophosphate synthase (3,560 words) [view diff] exact match in snippet view article find links to article

C-terminus in most eukaryotes (e.g., Metazoa, Amoebozoa, Plantae, and Heterolobosea), the inverted fusion, which is to say OPRTase at the C-terminus and

KLRC4 (941 words) [view diff] no match in snippet view article find links to article

proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located

RCBTB1 (577 words) [view diff] exact match in snippet view article find links to article

gene in vascular smooth muscle cells induced cellular hypertrophy. The C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this

Maltase-glucoamylase (1,284 words) [view diff] exact match in snippet view article find links to article

similar throughout the N and C-termini. Further studies have found that the C-terminus is composed of 21 more amino acid residues than the N-terminus, which

HBXIP (731 words) [view diff] exact match in snippet view article find links to article

gene. This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is

ATP2B2 (977 words) [view diff] exact match in snippet view article find links to article

binding calcium ion binding metal ion binding calmodulin binding protein C-terminus binding protein binding ATP binding hydrolase activity P-type calcium

Thiosulfate dehydrogenase (1,519 words) [view diff] no match in snippet view article find links to article

distance of 8.1 Å which assists with rapid electron transfer. Both the N and C terminus domains contain 4 α helices (surrounding the heme in the corresponding

NAGPA (701 words) [view diff] exact match in snippet view article find links to article

homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma

DAPK3 (843 words) [view diff] exact match in snippet view article find links to article

binding protein binding identical protein binding ATP binding protein C-terminus binding Cellular component PML body actin filament membrane raft nucleus

KCNN1 (668 words) [view diff] exact match in snippet view article find links to article

Zhang BM, Kohli V, Adachi R, et al. (2001). "Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by

INTS6 (665 words) [view diff] exact match in snippet view article find links to article

a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In

Thermosome (602 words) [view diff] exact match in snippet view article find links to article

the second ring when ADP is bound to the first ring. The N-terminus and C-terminus of thermosomes are arranged in an anti-parallel fashion and their interactions

DNM1 (1,472 words) [view diff] exact match in snippet view article find links to article

kinase binding microtubule binding RNA binding GTPase activity protein C-terminus binding D2 dopamine receptor binding protein-containing complex binding

Sortase A (698 words) [view diff] exact match in snippet view article find links to article

is engineered to be at the C-terminus of the protein. A (Gly)n molecule is engineered to contain the label at its C-terminus. Finally, both N and C-termini

PROP1 (957 words) [view diff] exact match in snippet view article find links to article

transcription repressor activity, RNA polymerase II-specific protein C-terminus binding DNA-binding transcription activator activity, RNA polymerase II-specific

Dishevelled (1,387 words) [view diff] exact match in snippet view article find links to article

(N-terminus) domain, a PDZ (central) domain, a carboxyl-terminal DEP (C-terminus) domain, and two regions with positively charged amino acid residues.

Plant peptide hormone (1,928 words) [view diff] exact match in snippet view article find links to article

leaves. It was found to be an 18-amino acid peptide processed from the C-terminus of a 200-amino acid precursor, which is called prosystemin. CLV3/ESR-related

SCNN1G (3,401 words) [view diff] exact match in snippet view article find links to article

ubiquitin-protein ligase named Nedd4-2. Nedd4-2 ligates ubiquitin to the C-terminus of the ENaC subunit which marks the protein for degradation. At present

HESX1 (1,024 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function sequence-specific DNA binding protein C-terminus binding chromatin binding protein binding protein N-terminus binding DNA-binding

Caveolae (1,461 words) [view diff] exact match in snippet view article find links to article

scaffolding domain, long hairpin transmembrane domain and cytoplasmic C-terminus. Caveolins are synthesized as monomers and transported to the Golgi apparatus

HESX1 (1,024 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function sequence-specific DNA binding protein C-terminus binding chromatin binding protein binding protein N-terminus binding DNA-binding

Caveolae (1,461 words) [view diff] exact match in snippet view article find links to article

scaffolding domain, long hairpin transmembrane domain and cytoplasmic C-terminus. Caveolins are synthesized as monomers and transported to the Golgi apparatus

FPG IleRS zinc finger (738 words) [view diff] no match in snippet view article find links to article

bifunctional base excision repair enzymes. Fpg binds one ion of zinc at the C terminus, which contains four conserved and essential cysteines. Endonuclease VIII

ATP1B1 (1,011 words) [view diff] exact match in snippet view article find links to article

sodium:potassium-exchanging transporter activity ATPase activity protein C-terminus binding protein binding MHC class II protein complex binding ATPase activator

Desmosome (1,221 words) [view diff] exact match in snippet view article find links to article

needed] The inner dense plaque, also about 15–20 nm in length, contains the C-terminus end of desmoplakin and their attachment to keratin intermediate filaments

Proteoglycan 4 (3,667 words) [view diff] exact match in snippet view article find links to article

N-terminus of lubricin is associated with its SMB-like domains, whereas the C-terminus is associated with the hemopexin-like domain. Due to the protein's overall

Plant peptide hormone (1,928 words) [view diff] exact match in snippet view article find links to article

leaves. It was found to be an 18-amino acid peptide processed from the C-terminus of a 200-amino acid precursor, which is called prosystemin. CLV3/ESR-related

Tensin (720 words) [view diff] exact match in snippet view article find links to article

filaments and contains a phosphotyrosine-binding (PTB) domain at the C-terminus, which interacts with the cytoplasmic tail of β integrins. These interactions

X8 protein domain (277 words) [view diff] no match in snippet view article find links to article

The domain is also found in an Olive pollen allergen as well as at the C terminus of family 17 glycosyl hydrolases. Simpson C, Thomas C, Findlay K, Bayer

Ocular albinism type 1 (2,871 words) [view diff] exact match in snippet view article find links to article

trans-membrane regions but very rarely in the much conserved cytoplasmic C-terminus. Populations belonging to different ethnic groups have been extensively

Synovial sarcoma (1,519 words) [view diff] exact match in snippet view article find links to article

(19 June 2020). "When used together SS18–SSX fusion-specific and SSX C-terminus immunohistochemistry are highly specific and sensitive for the diagnosis

Extracellular matrix protein 1 (798 words) [view diff] exact match in snippet view article find links to article

receptor binding signal transducer activity protease binding protein C-terminus binding protein binding enzyme binding laminin binding Cellular component

TAS2R10 (1,384 words) [view diff] no match in snippet view article find links to article

GPCR proteins range in size from 25-150 amino acids attached to the C- terminus and can be 80-480 Å in length. In mammals, bitter taste is used as a

TCF4 (1,156 words) [view diff] exact match in snippet view article find links to article

polymerase II-specific bHLH transcription factor binding E-box binding protein C-terminus binding protein binding identical protein binding TFIIB-class transcription

CendR (590 words) [view diff] exact match in snippet view article find links to article

with its receptor only when the second basic residue is exposed at the C-terminus. C-terminal CendR motif engages with widely expressed neuropilin-1 receptors

Basal cell adhesion molecule (1,272 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function laminin receptor activity protein C-terminus binding protein binding laminin binding transmembrane signaling receptor

Prokaryotic ubiquitin-like protein (1,725 words) [view diff] exact match in snippet view article find links to article

from Pup and Ubiquitin, UBact does not contain a di-glycine motif at its C-terminus. Rather, it usually ends with the sequence R[T/S]G[E/Q] (see figure 3)

Lactase (2,101 words) [view diff] exact match in snippet view article find links to article

epithelial cells. It is oriented with the N-terminus outside the cell and the C-terminus in the cytosol. LPH contains two catalytic glutamic acid sites. In the

Scotophilus bat coronavirus 512 (389 words) [view diff] exact match in snippet view article find links to article

spike protein shares similar deletions with group 2 coronaviruses in the C-terminus. Murinae Zoonosis taxonomy. "Taxonomy browser (Scotophilus bat coronavirus

POU3F4 (1,138 words) [view diff] exact match in snippet view article find links to article

in POU3F4 Frameshift truncation and extension mutations at the POU3F4 C-terminus Physical anomalies caused by POU3F4 mutations that have been recognized

Adnaviria (1,666 words) [view diff] exact match in snippet view article find links to article

rod-shaped virus 2 (SIRV2). The four-helix bundle is found at the end (C-terminus) of the protein while the beginning (N-terminus) of the protein has an

Angiomotin (2,243 words) [view diff] exact match in snippet view article find links to article

coiled-coil domains at N-terminus and consensus PDZ-binding domain at the C-terminus. Angiomotin is expressed predominantly in endothelial cells of capillaries

CD63 (1,581 words) [view diff] exact match in snippet view article find links to article

deletion and point mutants were used to investigate the role of the C-terminus, which contains a putative lysosomal-targeting/internalisation motif (GYEVM)

ELK1 (2,465 words) [view diff] exact match in snippet view article find links to article

encoded by the Fos gene, Elk1 needs to be phosphorylated by MAPKs at its C-terminus. MAPKs are the final effectors of signal transduction pathways that begin

KCNJ12 (1,195 words) [view diff] no match in snippet view article find links to article

Art JJ, Nakajima Y, Nakajima S (Jun 2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's

Ap180 (403 words) [view diff] exact match in snippet view article find links to article

and lymphoid leukemias where some translocations map to this gene. The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis

Glucagon receptor (1,332 words) [view diff] exact match in snippet view article find links to article

Glucagon, the Receptor activity-modifying protein, and the G-protein C-terminus has been determined using a computational and experimental approach. A

ASIC3 (965 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

PFKM (1,932 words) [view diff] exact match in snippet view article find links to article

metal ion binding kinase activity fructose binding kinase binding protein C-terminus binding catalytic activity protein binding identical protein binding phosphofructokinase

C-terminal processing peptidase (255 words) [view diff] exact match in snippet view article find links to article

Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala

SH3 domain (933 words) [view diff] exact match in snippet view article find links to article

chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus). Identifiers Symbol SH3_1 Pfam PF00018 Pfam clan CL0010 ECOD 4.1.1 InterPro

Cyclic nucleotide-gated channel alpha 3 (971 words) [view diff] exact match in snippet view article find links to article

ion channel activity voltage-gated potassium channel activity protein C-terminus binding intracellular cAMP-activated cation channel activity Cellular

FXYD2 (957 words) [view diff] exact match in snippet view article find links to article

members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane

ELK1 (2,465 words) [view diff] exact match in snippet view article find links to article

encoded by the Fos gene, Elk1 needs to be phosphorylated by MAPKs at its C-terminus. MAPKs are the final effectors of signal transduction pathways that begin

KCNJ12 (1,195 words) [view diff] no match in snippet view article find links to article

Art JJ, Nakajima Y, Nakajima S (Jun 2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's

N-acetyltransferase (1,638 words) [view diff] exact match in snippet view article find links to article

formation of a Cisplatin adduct with the active-site cysteine residue. The C-terminus helps bind acetyl CoA and differs among NATs including prokaryotic homologues

SH3 domain (933 words) [view diff] exact match in snippet view article find links to article

chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus). Identifiers Symbol SH3_1 Pfam PF00018 Pfam clan CL0010 ECOD 4.1.1 InterPro

Munc-18 (806 words) [view diff] exact match in snippet view article find links to article

fusion It has also been shown in one study that Munc-18 binds to the C-terminus of synaptobrevin, suggesting that this protein plays an important role

Fusion protein (2,305 words) [view diff] no match in snippet view article find links to article

fragments are typically added to reduce flexibility of either the N or C terminus of the target protein, which reinforces thermostability and stabilizes

KLRD1 (1,386 words) [view diff] no match in snippet view article find links to article

is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence

Utrophin (1,314 words) [view diff] exact match in snippet view article find links to article

to express dystrophin. The tertiary structure of utrophin contains a C-terminus that consists of protein–protein interaction motifs that interact with

Kir6.2 (1,212 words) [view diff] exact match in snippet view article find links to article

rectifier potassium channel activity ATP binding protein binding protein C-terminus binding heat shock protein binding Cellular component integral component

Chemokine receptor (1,559 words) [view diff] exact match in snippet view article find links to article

intracellular and three extracellular hydrophilic loops, and an intracellular C-terminus containing serine and threonine residues that act as phosphorylation sites

Mucin 17 (434 words) [view diff] exact match in snippet view article find links to article

PMID 20926598. Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that

Syncytin-1 (2,024 words) [view diff] exact match in snippet view article find links to article

ectodomain of ASCT1 and ASCT2, extracellular loop 2 (ECL2), contains at its C-terminus a 21 residue hypervariable region between human, mouse, and hamster receptors

SNX17 (785 words) [view diff] exact match in snippet view article find links to article

(2001). "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): 1045–50. doi:10

NEDD8 (2,836 words) [view diff] exact match in snippet view article find links to article

Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochemical and Biophysical Research Communications

SEMA3F (1,081 words) [view diff] no match in snippet view article find links to article

collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development

PIAS4 (1,159 words) [view diff] exact match in snippet view article find links to article

ligase binding SUMO transferase activity transferase activity protein C-terminus binding Cellular component cytoplasm PML body nuclear matrix transferase

Cenderitide (1,374 words) [view diff] exact match in snippet view article find links to article

heart failure. Cenderitide is created by the fusion of the 15 amino acid C-terminus of the snake venom dendroaspis natriuretic peptide (DNP) with the full

H2AFJ (487 words) [view diff] exact match in snippet view article find links to article

12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. GRCh38: Ensembl release

Type IV collagen C4 domain (381 words) [view diff] exact match in snippet view article find links to article

domain (or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens. Each type IV collagen contains a long triple-helical

Mef2 (1,906 words) [view diff] exact match in snippet view article find links to article

heterodimerize, and a classic nuclear localization sequence (NLS) in the C-terminus of Mef2A, -C, and – D ensures nuclear localization of the protein. D-Mef2

CCL1 (1,363 words) [view diff] exact match in snippet view article find links to article

suppress the apoptotic activity of CCL1, removing three amino acids from the C-terminus of CCL1 reduces CCR8 binding but converts CCL1 to a more potent CCR8 agonist

Monte Compatri-Pantano (Rome Metro) (115 words) [view diff] no match in snippet view article

Preceding station Rome Metro Following station Graniti towards San Giovanni Line C Terminus

SNTG1 (608 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function actin binding protein C-terminus binding structural molecule activity Cellular component cytoplasm ruffle membrane syntrophin

KCNJ6 (1,377 words) [view diff] no match in snippet view article find links to article

Kaziro Y, Itoh H, Art JJ, et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's

ASIC1 (1,330 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

DYRK2 (585 words) [view diff] no match in snippet view article find links to article

PMC 139241. PMID 12477932. Wang X, Li W, Parra JL, et al. (2003). "The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains Multiple Regulatory

KCNK3 (1,050 words) [view diff] exact match in snippet view article find links to article

activity protein heterodimerization activity growth factor activity protein C-terminus binding protein binding Cellular component integral component of membrane

KCNJ3 (1,129 words) [view diff] no match in snippet view article find links to article

Chen L, Kawano T, Bajic S, et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's

Polycystin 1 (839 words) [view diff] no match in snippet view article find links to article

stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus". The Journal of Clinical Investigation. 114 (10): 1433–43. doi:10.1172/JCI21753

ASIC1 (1,330 words) [view diff] exact match in snippet view article find links to article

are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel through which ions selectively flow from the

BAG domain (356 words) [view diff] no match in snippet view article find links to article

four BAG repeats. The BAG domain is a conserved region located at the C terminus of the BAG-family proteins that binds the ATPase domain of Hsc70/Hsp70

Junctional adhesion molecule (1,824 words) [view diff] exact match in snippet view article find links to article

protein interaction modules that target short amino acid sequences at the C-terminus of proteins, to form tight junctions in both epithelial and endothelial

KCNK3 (1,050 words) [view diff] exact match in snippet view article find links to article

activity protein heterodimerization activity growth factor activity protein C-terminus binding protein binding Cellular component integral component of membrane

Oxaloacetate decarboxylase (1,349 words) [view diff] exact match in snippet view article find links to article

coordination of a Zn2+ metal ion by several residues at the hydrophilic C-terminus. The alpha subunit, which is ~65kDa, is a biotinylated peripheral membrane

Glutathione S-transferase (4,293 words) [view diff] exact match in snippet view article find links to article

forms through direct protein–protein interactions between GSTP and the C-terminus of JNK, effectively preventing the action of JNK and thus its induction

PIAS1 (1,351 words) [view diff] exact match in snippet view article find links to article

specific binding SUMO transferase activity transferase activity protein C-terminus binding Cellular component PML body nuclear speck nucleoplasm nucleus

Neurotensin receptor 1 (1,632 words) [view diff] exact match in snippet view article find links to article

extended conformation nearly perpendicular to the membrane, with the C-terminus oriented toward the receptor core. Key interactions involve charged residues

Cleavage and polyadenylation specificity factor (1,898 words) [view diff] no match in snippet view article find links to article

zinc-finger motifs near the N terminus and a CCCH zinc knuckle at the C terminus. Two isoforms of CPSF-30 exist and can be found in CPSF complexes. The

Microtubule (7,911 words) [view diff] exact match in snippet view article find links to article

tyrosine from alpha-tubulin. This reaction exposes a glutamate at the new C-terminus. As a result, microtubules that accumulate this modification are often

DYNLL1 (1,545 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function protein domain specific binding protein C-terminus binding protein binding cytoskeletal motor activity cytoskeletal protein

C5a receptor (1,767 words) [view diff] no match in snippet view article find links to article

receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a". Journal of Medicinal Chemistry. 41 (18):

Flavodoxin fold (122 words) [view diff] exact match in snippet view article find links to article

chemotactic response in bacteria, PDB accession code 3CHY), which adopts the flavodoxin fold. Ribbon is colored from blue (N-terminus) to red (C-terminus).

VAMP1 (926 words) [view diff] exact match in snippet view article find links to article

HJ, Dahl R, Petersen TE (November 1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing". Biochemical and Biophysical Research

Pestivirus (3,937 words) [view diff] exact match in snippet view article find links to article

a significant amount is secreted into the medium of infected. Erns's C-terminus serves as a membrane anchor, a retention/secretion signal, a binding site

FXYD1 (776 words) [view diff] exact match in snippet view article find links to article

members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene

Tropomyosin 3 (888 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 1mv4: TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin 2g9j: Complex of TM1a(1-14)Zip with TM9a(251-284):

Mitosis inducer protein kinase cdr2 (672 words) [view diff] exact match in snippet view article find links to article

sequence characteristic of serine/threonine protein kinase activity. The C-terminus, while non-catalytic, is necessary for proper localization of Cdr2 during

Complement component 5 (1,114 words) [view diff] exact match in snippet view article find links to article

streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". Biochem. J. 273 (Pt 3): 635–40. doi:10.1042/bj2730635. PMC 1149811.

Poneratoxin (1,434 words) [view diff] exact match in snippet view article find links to article

are formed by residues 3–9 at the N-terminus, and residues 17–24 at the C-terminus, and they are connected by the beta-turn at residues 11–16. From a three-dimensional

Tyrosine-protein kinase CSK (977 words) [view diff] exact match in snippet view article find links to article

non-membrane spanning protein tyrosine kinase activity metal ion binding protein C-terminus binding protein binding identical protein binding protein tyrosine kinase

Tight junction (2,079 words) [view diff] exact match in snippet view article find links to article

consists of four transmembrane domains and both the N-terminus and the C-terminus of the protein are intracellular. It forms two extracellular loops and

Collagen, type I, alpha 1 (1,810 words) [view diff] exact match in snippet view article find links to article

acid in the protein strand. Sometimes one end of the gene (called the C-terminus) is altered, which interferes with the association of the protein strands

Rimantadine (1,857 words) [view diff] no match in snippet view article find links to article

ammonium group (with neighboring water molecules) is positioned towards the C terminus with the amantadane group is positioned towards the N-terminus when bound

Arrestin beta 2 (1,965 words) [view diff] no match in snippet view article find links to article

determined by their intact N domain and the nuclear export signal at the C terminus". The Journal of Biological Chemistry. 278 (13): 11648–53. doi:10.1074/jbc

HLA-B (1,889 words) [view diff] case mismatch in snippet view article find links to article

POSITIONING OF THE C-TERMINUS 1a9e: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS 1agb: ANTAGONIST

RBCK1 (1,088 words) [view diff] exact match in snippet view article find links to article

ligases, HOIL-1 is able to catalyze oxyester bond formation between the C-terminus of a ubiquitin monomer and Ser/Thr of a different protein. This recently

Arylomycin (740 words) [view diff] no match in snippet view article find links to article

in the signal peptidase Ala-X-Ala recognition motif. Additionally, the C terminus of the arylomycins is seen to be within hydrogen bonding distance of the

TAX1BP3 (726 words) [view diff] exact match in snippet view article find links to article

PMC 3433589. PMID 22876914. Rousset R, Fabre S, Desbois C, et al. (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain

SLC22A12 (1,082 words) [view diff] no match in snippet view article find links to article

regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus". J. Biol. Chem. 279 (44): 45942–50. doi:10.1074/jbc.M406724200. PMID 15304510

Sterol regulatory element-binding protein 2 (1,451 words) [view diff] exact match in snippet view article find links to article

repressor activity, RNA polymerase II-specific E-box binding protein C-terminus binding protein binding DNA-binding transcription factor activity, RNA

Triosephosphate isomerase (1,178 words) [view diff] exact match in snippet view article find links to article

backbone of each subunit is colored in blue to red from N-terminus to C-terminus. This structural motif is called an αβ-barrel, or a TIM-barrel, and is

ERCC4 (3,315 words) [view diff] exact match in snippet view article find links to article

the C terminus of the XPF protein., but residues in the nuclease domain are not present. A DNA binding "helix-hairpin-helix" domain at the C-terminus of

SmeT (1,855 words) [view diff] exact match in snippet view article find links to article

the rest of α4, α5, α6, and α7 form the effector binding pocket in the C-terminus. α8 and α9 allow the dimerization of the protein. Hydrophobic interactions

MYO1C (918 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function protein C-terminus binding nucleotide binding actin binding signaling receptor binding cytoskeletal motor activity calmodulin

SmeT (1,855 words) [view diff] exact match in snippet view article find links to article

the rest of α4, α5, α6, and α7 form the effector binding pocket in the C-terminus. α8 and α9 allow the dimerization of the protein. Hydrophobic interactions

ARR3 (828 words) [view diff] no match in snippet view article find links to article

dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif". J. Biol. Chem. 277 (9): 7356–62. doi:10.1074/jbc

Mercury(II) reductase (1,464 words) [view diff] no match in snippet view article

residues (Cys-558' and Cys-559') are found near the surface near the C terminus. The buried cysteine residues function as the site of catalysis whereas

Laminin subunit alpha-1 (1,008 words) [view diff] exact match in snippet view article find links to article

binding extracellular matrix structural constituent protein binding protein C-terminus binding glycosphingolipid binding Cellular component extracellular matrix

Pacer (protein) (589 words) [view diff] exact match in snippet view article

regulation of PI3KC3. Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated

PPP2CA (1,716 words) [view diff] exact match in snippet view article find links to article

phosphatase activity GABA receptor binding metal ion binding protein C-terminus binding protein binding hydrolase activity protein heterodimerization

TAS2R14 (2,021 words) [view diff] no match in snippet view article find links to article

chimeric Gα16 (type of Gαq), harboring 44 gustducin specific sequence at its C terminus, or Gαqi5, a Gαq protein containing the five carboxyl-terminal amino acids

Auxin binding protein (1,593 words) [view diff] no match in snippet view article find links to article

the lumen of the ER correlates with an additional signal located at the C terminus, represented by the sequence Lys-Asp-Glu-Leu, known to be responsible

Baculoviridae (2,862 words) [view diff] exact match in snippet view article find links to article

oligomerization and fusion domain and a hydrophobic transmembrane domain near the C-terminus (7 aa).[citation needed] It is produced in both early and late phases

Asparagine endopeptidase (1,932 words) [view diff] exact match in snippet view article find links to article

the LGMN gene (previous symbol PRSC1). It hydrolyzes substrates at the C-terminus of asparagine residues. Discovered in 1996 in beans, its homologues have

ID1 (1,953 words) [view diff] exact match in snippet view article find links to article

DNA-binding transcription factor activity protein self-association protein C-terminus binding protein binding DNA-binding transcription factor activity, RNA

MPDZ (1,136 words) [view diff] exact match in snippet view article find links to article

multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8

Copine (385 words) [view diff] exact match in snippet view article find links to article

proteins that exhibit a single C2 domain. The core domain located at the C-terminus part of the copine is found to have a unique and conserved primary sequence

Argininosuccinate synthase (1,737 words) [view diff] exact match in snippet view article find links to article

subunits contain a number of salt bridges and hydrogen bonds, and the C-terminus of each subunit is involved in oligomerization by interacting with the

YY1 (1,909 words) [view diff] exact match in snippet view article find links to article

transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". Journal of Cellular

DnaQ (1,473 words) [view diff] exact match in snippet view article find links to article

binds the θ subunit and carries out the exonuclease function and the C-terminus binds the α subunit responsible for polymerase activity. A Q-linker peptide

Epiplakin (909 words) [view diff] no match in snippet view article find links to article

consists of 13 domains which are all similar to the B domain located at the C terminus of the human epidermal and cardiac muscle protein desmoplakin. The domains

Lysine carboxypeptidase (2,161 words) [view diff] exact match in snippet view article find links to article

specifically a carboxypeptidase (sub-subclasses 16-18) which acts on a C-terminus to break off one amino acid. The overall category of metallocarboxypeptidases

HCN channel (1,568 words) [view diff] exact match in snippet view article find links to article

K+-permeable channels, and a cyclic nucleotide-binding domain (CNBD) in the C-terminus. HCN isoforms are highly conserved in their core transmembrane regions

Butyrylcholinesterase (2,228 words) [view diff] exact match in snippet view article find links to article

Altamirano CV, Lockridge O (October 1999). "Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers".

MAP2K1 (1,478 words) [view diff] exact match in snippet view article find links to article

Molecular function protein N-terminus binding kinase activity protein C-terminus binding ATP binding transferase activity protein serine/threonine kinase

Beta-2 microglobulin (2,118 words) [view diff] case mismatch in snippet view article find links to article

POSITIONING OF THE C-TERMINUS 1a9e: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS 1agb: ANTAGONIST

Soluble guanylyl cyclase (1,177 words) [view diff] exact match in snippet view article find links to article

determined (pdb code 3HLS). The 250-residue guanylate cyclase domain at the C-terminus of sGC is highly conserved in soluble and membrane bound guanylyl cyclases

L-gulonolactone oxidase (2,432 words) [view diff] exact match in snippet view article find links to article

helices that make up the structure of L-gulonolactone oxidase. Lime green is showing the N-terminus. Red is displaying the C-terminus end of the protein.

SNTB1 (1,034 words) [view diff] exact match in snippet view article find links to article

Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (Mar 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain

Secretion (2,981 words) [view diff] exact match in snippet view article find links to article

use this pathway have the capability to form a beta-barrel with their C-terminus which inserts into the outer membrane, allowing the rest of the peptide

Homeobox protein NANOG (2,462 words) [view diff] exact match in snippet view article find links to article

of hNanog is rich in serine, threonine and proline residues, and the C-terminus contains a tryptophan-rich domain. The homeodomain in hNANOG ranges from

Latrotoxin (2,273 words) [view diff] exact match in snippet view article find links to article

and activate the α-LTX precursor molecules by means of hydrolysis. The C-terminus too is recognized by these furin-like proteases and is also cleaved. α-LTX

Tabtoxin (1,045 words) [view diff] no match in snippet view article find links to article

differing by having an extra threonine attached by a peptide bond to the C terminus. Tabtoxin is required by BR2(R) for both chlorosis and lesion formation

Nebulette (919 words) [view diff] exact match in snippet view article find links to article

N-terminus, and a serine-rich region adjacent to an SH3 domain at its C-terminus. Though nebulette shares structural features with nebulin, nebulin is

DAX1 (1,842 words) [view diff] exact match in snippet view article find links to article

Murashita M, Mukai T, Imanaka K, Fujieda K (Oct 1996). "Truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked

Melanin-concentrating hormone receptor 1 (2,033 words) [view diff] exact match in snippet view article find links to article

activity neuropeptide receptor activity signaling receptor binding protein C-terminus binding hormone binding neuropeptide binding peptide binding Cellular

Ubiquitin carboxy-terminal hydrolase L1 (2,637 words) [view diff] exact match in snippet view article find links to article

H, Kito K, Caskey LS, Yeh ET, Kamitani T (Oct 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochemical and Biophysical Research Communications

Dourdan-la-Forêt station (64 words) [view diff] no match in snippet view article find links to article

Preceding station RER Following station Dourdan towards Pontoise, Versailles Château Rive Gauche or Saint-Quentin-en-Yvelines RER C Terminus

SMG6 (1,738 words) [view diff] exact match in snippet view article find links to article

17. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a PilT N-terminus (PIN) domain. This structure

Von Willebrand factor (1,998 words) [view diff] exact match in snippet view article find links to article

shear flow, calcium binding, and a "vicinal disulfide" at the A2-domain’s C-terminus. The A3 domain: Acts as the primary collagen binding site for VWF, binding

Thermostability (2,222 words) [view diff] exact match in snippet view article find links to article

protein. Cyclizing enzymes by covalently linking the N-terminus to the C-terminus has been applied to increase the thermostability of many enzymes. Intein

Alanine racemase (1,390 words) [view diff] no match in snippet view article find links to article

covalently linked via an aldimine linkage to a lysine residue, which is at the C terminus of the first beta-strand of the alpha/beta barrel. Reaction mechanisms

Transmissible gastroenteritis virus (1,145 words) [view diff] exact match in snippet view article find links to article

domains within the E2 protein. A 20 residue hydrophobic segment at the C-terminus anchors the protein in the lipid membrane. The rest of the protein is

MSMB (2,098 words) [view diff] exact match in snippet view article find links to article

remarkable similarity despite having only 51% of amino acids in common. The C-terminus domain of MSMB contains two two-stranded β-sheets; these have no resemblance

Myosin light-chain kinase (1,731 words) [view diff] case mismatch in snippet view article find links to article

binding to myosin light chain. This myosin binding domain is located at the C-Terminus end of the kinase. On the other side of the kinase at the N-Terminus end

Kisspeptin (3,317 words) [view diff] exact match in snippet view article find links to article

RFamides which all share a common arginine-phenylalanine-NH2 motif at their C-terminus. Among these conserved amino acids are arginine and phenylalanine residues

Landover station (607 words) [view diff] no match in snippet view article find links to article

Preceding station Pennsylvania Railroad Following station Washington, D.C. Terminus Philadelphia, Wilmington and Baltimore Railroad Lanham toward Philadelphia

Episodic ataxia (3,132 words) [view diff] exact match in snippet view article find links to article

Slower , V408A C-terminus 68% Unchanged Faster Faster Shorter mean open time, more and larger sIPSCs in Mice ,,,,,,, R417X C-terminus 2% 9mV positive

Pemphigoid (5,868 words) [view diff] exact match in snippet view article find links to article

skin. The major basement membrane zone proteins identified include : C-terminus of BP180 BP230 Laminin 332(also known as laminin 5 or epiligrin) Alpha-6-beta-4

Batroxobin (2,033 words) [view diff] exact match in snippet view article find links to article

exosite 2 causes an interaction with a second fibrinogen molecule at the C-terminus of the y’-chain. Consequently, when thrombin binds a yA/yA fibrinogen

CTGF (1,537 words) [view diff] exact match in snippet view article find links to article

function fibronectin binding insulin-like growth factor binding protein C-terminus binding protein binding growth factor activity integrin binding heparin

CDKN2B (1,386 words) [view diff] exact match in snippet view article find links to article

proteins that share the N-terminal sequence but completely differ in the C-terminus. CDKN2B tumor suppressor gene product p15 has been shown to interact with

Ficain (1,346 words) [view diff] exact match in snippet view article find links to article

structure of ficain from Ficus carica, rainbow colored, N-terminus blue, C-terminus red. Identifiers EC no. 3.4.22.3 CAS no. 9001-33-6 Databases IntEnz IntEnz

Klampenborg station (495 words) [view diff] no match in snippet view article find links to article

Elsinore–Copenhagen–Roskilde–Næstved Regional train Hellerup towards Næstved Preceding station S-train Following station Ordrup towards Frederikssund C Terminus

EP300 (4,193 words) [view diff] no match in snippet view article find links to article

"Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4". J. Biol. Chem. 278 (6):

Dystonin (1,478 words) [view diff] exact match in snippet view article find links to article

microtubule plus-end binding metal ion binding integrin binding protein C-terminus binding protein binding actin binding microtubule binding structural molecule

Peptidoglycan binding domain (674 words) [view diff] no match in snippet view article find links to article

three-helical bundle with a left-handed twist. It is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. Examples

5-HT3 receptor (2,440 words) [view diff] exact match in snippet view article find links to article

involved in receptor trafficking and regulation; and a short extracellular C-terminus (Fig.1). Whereas extracellular domain is the site of action of agonists

Sigma factor (2,045 words) [view diff] exact match in snippet view article find links to article

(domains) that are generally conserved: N-terminus --------------------- C-terminus 1.1 2 3 4 The regions are further subdivided. For example, region 2 includes

P2RX7 (3,366 words) [view diff] no match in snippet view article find links to article

proteins induce membrane blebbing and interact with the P2X7 receptor C terminus". The Journal of Biological Chemistry. 277 (37): 34017–23. doi:10.1074/jbc

Massy–Palaiseau station (154 words) [view diff] no match in snippet view article find links to article

towards Saint-Rémy-lès-Chevreuse Massy–Verrières towards Pontoise RER C Terminus Preceding station Transilien Following station Igny towards Versailles-Chantiers

Metabotropic glutamate receptor 1 (2,342 words) [view diff] no match in snippet view article find links to article

Robbins MJ, Willis AC, McIlhinney RA (January 1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins:

Guanine nucleotide exchange factor (2,253 words) [view diff] no match in snippet view article find links to article

family members. The PH domain is located immediately adjacent to the C terminus of the DH domain. Together, these two domains constitute the minimum structural

Insect olfactory receptor (548 words) [view diff] exact match in snippet view article find links to article

reversed topology, with an intracellular N-terminus and an extracellular C-terminus. Differently to mammalian ORs, insect ORs form a heteromer with a fixed