Find link

language: af: Afrikaans als: Alemannisch [Alemannic] am: አማርኛ [Amharic] an: aragonés [Aragonese] ar: العربية [Arabic] arz: مصرى [Egyptian Arabic] as: অসমীয়া [Assamese] ast: asturianu [Asturian] az: azərbaycanca [Azerbaijani] azb: تۆرکجه [Southern Azerbaijani] ba: башҡортса [Bashkir] bar: Boarisch [Bavarian] bat-smg: žemaitėška [Samogitian] be: беларуская [Belarusian] be-tarask: беларуская (тарашкевіца) [Belarusian (Taraškievica)] bg: български [Bulgarian] bn: বাংলা [Bengali] bpy: বিষ্ণুপ্রিয়া মণিপুরী [Bishnupriya Manipuri] br: brezhoneg [Breton] bs: bosanski [Bosnian] bug: ᨅᨔ ᨕᨘᨁᨗ [Buginese] ca: català [Catalan] ce: нохчийн [Chechen] ceb: Cebuano ckb: کوردیی ناوەندی [Kurdish (Sorani)] cs: čeština [Czech] cv: Чӑвашла [Chuvash] cy: Cymraeg [Welsh] da: dansk [Danish] de: Deutsch [German] el: Ελληνικά [Greek] en: English eo: Esperanto es: español [Spanish] et: eesti [Estonian] eu: euskara [Basque] fa: فارسی [Persian] fi: suomi [Finnish] fo: føroyskt [Faroese] fr: français [French] fy: Frysk [West Frisian] ga: Gaeilge [Irish] gd: Gàidhlig [Scottish Gaelic] gl: galego [Galician] gu: ગુજરાતી [Gujarati] he: עברית [Hebrew] hi: हिन्दी [Hindi] hr: hrvatski [Croatian] hsb: hornjoserbsce [Upper Sorbian] ht: Kreyòl ayisyen [Haitian] hu: magyar [Hungarian] hy: Հայերեն [Armenian] ia: interlingua [Interlingua] id: Bahasa Indonesia [Indonesian] io: Ido is: íslenska [Icelandic] it: italiano [Italian] ja: 日本語 [Japanese] jv: Basa Jawa [Javanese] ka: ქართული [Georgian] kk: қазақша [Kazakh] kn: ಕನ್ನಡ [Kannada] ko: 한국어 [Korean] ku: Kurdî [Kurdish (Kurmanji)] ky: Кыргызча [Kirghiz] la: Latina [Latin] lb: Lëtzebuergesch [Luxembourgish] li: Limburgs [Limburgish] lmo: lumbaart [Lombard] lt: lietuvių [Lithuanian] lv: latviešu [Latvian] map-bms: Basa Banyumasan [Banyumasan] mg: Malagasy min: Baso Minangkabau [Minangkabau] mk: македонски [Macedonian] ml: മലയാളം [Malayalam] mn: монгол [Mongolian] mr: मराठी [Marathi] mrj: кырык мары [Hill Mari] ms: Bahasa Melayu [Malay] my: မြန်မာဘာသာ [Burmese] mzn: مازِرونی [Mazandarani] nah: Nāhuatl [Nahuatl] nap: Napulitano [Neapolitan] nds: Plattdüütsch [Low Saxon] ne: नेपाली [Nepali] new: नेपाल भाषा [Newar] nl: Nederlands [Dutch] nn: norsk nynorsk [Norwegian (Nynorsk)] no: norsk bokmål [Norwegian (Bokmål)] oc: occitan [Occitan] or: ଓଡ଼ିଆ [Oriya] os: Ирон [Ossetian] pa: ਪੰਜਾਬੀ [Eastern Punjabi] pl: polski [Polish] pms: Piemontèis [Piedmontese] pnb: پنجابی [Western Punjabi] pt: português [Portuguese] qu: Runa Simi [Quechua] ro: română [Romanian] ru: русский [Russian] sa: संस्कृतम् [Sanskrit] sah: саха тыла [Sakha] scn: sicilianu [Sicilian] sco: Scots sh: srpskohrvatski / српскохрватски [Serbo-Croatian] si: සිංහල [Sinhalese] simple: Simple English sk: slovenčina [Slovak] sl: slovenščina [Slovenian] sq: shqip [Albanian] sr: српски / srpski [Serbian] su: Basa Sunda [Sundanese] sv: svenska [Swedish] sw: Kiswahili [Swahili] ta: தமிழ் [Tamil] te: తెలుగు [Telugu] tg: тоҷикӣ [Tajik] th: ไทย [Thai] tl: Tagalog tr: Türkçe [Turkish] tt: татарча/tatarça [Tatar] uk: українська [Ukrainian] ur: اردو [Urdu] uz: oʻzbekcha/ўзбекча [Uzbek] vec: vèneto [Venetian] vi: Tiếng Việt [Vietnamese] vo: Volapük wa: walon [Walloon] war: Winaray [Waray] yi: ייִדיש [Yiddish] yo: Yorùbá [Yoruba] zh: 中文 [Chinese] zh-min-nan: Bân-lâm-gú [Min Nan] zh-yue: 粵語 [Cantonese]

jump to random article

searching for Direct binding 224 found (229 total)

alternate case: direct binding

Polyglutamylation (177 words) [view diff] exact match in snippet view article find links to article

forms of tubulins. These residues, though themselves not involved in direct binding, cause conformational shifts that regulate binding of microtubule associated

sulfate, bismuth oxide and zirconium oxide. Some solutions involve direct binding of heavy elements, for instance iodine, to polymeric chains in order

Fe(II)/Fe(III) coordination sites and the reaction proceeds through the direct binding of myo-inositol followed by attack of the iron center by diatomic oxygen

Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor

(June 2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165". J. Biol. Chem. 278 (26): 23656–65. doi:10

contributed a lot of time to decreasing program load time. He created the direct binding, hashvals, and dynsort implementations for GNU Binutils and glibc. Most

11.4741. PMID 8943374. Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins

11.4741. PMID 8943374. Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins

assembly or activity of retroviral pre-integration complexes through direct binding to the retroviral proteins p55 Gag and matrix, as well as to DNA. Furukawa

usual 5' cap-binding model. This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES)

Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the

interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative

2002). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Molecular Biology of the Cell. 13 (11): 4001–12.

AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S (2000). "Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for

TRPV3. Kunysz EL, Michel AD, Whiting RL (March 1988). "Functional and direct binding studies using subtype selective muscarinic receptor antagonists". British

1038/ng1285. PMID 14702039. Yamamoto Y, Irie K, Asada M, et al. (2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor

calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin

K, Guillier M, Leibovitch SA (Jun 2000). "Stabilization of MyoD by direct binding to p57(Kip2)". The Journal of Biological Chemistry. 275 (25): 18767–76

organization, polymerization, and branching of filamentous actin (F-actin) via direct binding to F-actin regulatory proteins. The first evidence that indicated

(November 1975). "Brain receptors for antipsychotic drugs and dopamine: direct binding assays". Proceedings of the National Academy of Sciences of the United

technique PICh (Proteomics of Isolated Chromatin segments). Subsequently, direct binding to telomeric DNA was demonstrated through a co-crystal structure of

involved in zymosan action. Sato M, Sano H, Iwaki D, et al. (2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation

Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the

minutes. Pharmacologically, like other capsaicinoids, PAVA works by direct binding to receptors (TRPV1) that normally produce the pain and sensation of

anxiolytic actions of kavain and related kavalactones are still debated. Direct binding to the benzodiazepine/flumazenil binding site of the GABA-A receptor

2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7):

regulator in T-lymphocyte development and function. This is through direct binding of miR-31 at its target site in the 3′UTR of FOXP3 mRNA. O'Day, E; Lal

Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood

cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer". Immunity. 3 (6): 801–809. doi:10

PMID 30419600. Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG (May 2001). "Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein

W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin

cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer". Immunity. 3 (6): 801–9. doi:10.1016/1074-7613(95)90069-1

for a component of the Midday Complex. LUX likely represses PRR9 via direct binding to a DNA sequence that has not yet been elucidated. PRR9 protein subsequently

until the start codon. The ribosome can localize to the start site by direct binding, initiation factors, and/or ITAFs (IRES trans-acting factors) bypassing

tyramine and phenethylamine trigger TAAR2 dependant actions, though direct binding has not been demonstrated. Trace amine Trace amine-associated receptor

of the basal transcriptional machinery, all of which do not require direct binding of Elk1 to DNA. Elk1 activation plays a central role in drug addiction

Holzbaur EL (December 1995). "Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex". The Journal of

Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels"

is possible for the inhibitor to operate via other means including direct binding to the active site. It differs from competitive inhibition in that the

Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin

distinct, pocket protein independent manner. E2F-6 mediates repression by direct binding to polycomb-group proteins or via the formation of a large multimeric

Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (February 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin

Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J (1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon

include direct binding to and activation of sex hormone receptors, direct inhibition of enzymes involved in steroidogenesis, and direct binding to and

2002). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Molecular Biology of the Cell. 13 (11): 4001–12.

PMID 8041791. Ward AC, Monkhouse JL, Hamilton JA, Csar XF (November 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating

exchange factor (GEF) 1". Kirsch KH, Georgescu MM, Hanafusa H (Oct 1998). "Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G". The Journal

2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7):

Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels"

observation that the positional distribution of binding sites matching the direct-binding motif tends to be unimodal, well centered and maximal in the precise

1997). "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments". The Journal of Cell Biology.

alter this binding efficacy. The miR-206 regulation of ERα through the direct binding of miR-206 in the ERα 3' UTR, is a good example of how a miRNA:mRNA

2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7):

perturbation to membrane lipid clusters and activation of phospholipase D2; direct binding of anesthetics to purified reconstituted TREK-1 had no effect on conductance

oocyte-specific genes. Regulation of these oocyte-specific genes is thru direct binding of NOBOX to its promoter regions via the specific consensus sequences

Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP (January 1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels"

Yates JR, Schroer TA (July 2014). "Dynactin integrity depends upon direct binding of dynamitin to Arp1". Molecular Biology of the Cell. 25 (14): 2171–80

SP, Huang DC, Orlowski J, Furthmayr H, Barber DL (December 2000). "Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton

distinct mechanisms: chromatin remodelation via enzyme recruitment and direct binding to enhancer sequences promoting transcription or 3D gene structure supporting

PMID 20406937. Ward AC, Monkhouse JL, Hamilton JA, Csar XF (November 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating

receptors that couple to inhibitory heterotrimeric G-proteins (Gi) via direct binding of the Gβγ subunit of the G-protein to the channel. Gβγ was shown to

Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of Chordin to BMP-4. Cell 86, 589-598. Piccolo, S., Agius, E., Lu, B

Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (December 1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

cytosol thereby inactivating it. CAR can be activated in two ways: by direct binding of a ligand (e.g. TCPOBOP) or indirect regulation by phenobarbital (PB)

and water retention. It has been suggested that this may be due to direct binding to and activation of the estrogen receptor by oxymetholone. Oxymetholone

Taipale, J; Cooper, M. (2002). "Inhibition of Hedgehog Signaling by direct binding of Cyclopamine to Smoothened". Genes Dev. 16 (21): 2743–2748. doi:10

Heemels MT, Neefjes JJ, Kast W, Melief CJ, Ploegh HL (August 1990). "Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro"

Instead of building up a complex at the 5′ cap, the IRES allows for direct binding of the ribosomal complexes to the transcript to begin translation. The

Sano H, Iwaki D, Kudo K, Konishi M, Takahashi H, et al. (July 2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation

S2CID 155219. Kouklis PD, Hutton E, Fuchs E (Nov 1994). "Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins". The

integrin binding protein 1 (CIB1). Trx inhibits ASK1 kinase activity by direct binding to its N-terminal coiled-coil domain (NCC). Trx and CIB1 regulate ASK1

the middle G:C pairs are connected with Asp154, Arg122, and Asn116 (direct binding). Hydrogen bonding between water and Asn116 results in binding at A:T

Domanski P, Handa R, Smalley D, Mullersman J, et al. (December 1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon

S2CID 35231493. Biederer T, Südhof TC (December 2000). "Mints as adaptors. Direct binding to neurexins and recruitment of munc18". The Journal of Biological Chemistry

binding proteins. The SNX-BAR dimer enters the nucleation complex via direct binding or lateral movement on endosomal surface. The increased level of Retromer

Borrelia spielmanii sp. nov. Resists Complement-Mediated Killing by Direct Binding of Immune Regulators Factor H and Factor H-Like Protein 1". Infection

"A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef". Biochem. Biophys. Res. Commun. 238 (1): 234–9. doi:10

2003). "Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1". Biochemical and Biophysical

by Cdr1, Cdr2, and Pom1. Cdk1-cyclin complexes are also governed by direct binding of Cdk inhibitor proteins (CKIs). One such protein, already discussed

(2002). "Onchocerca volvulus microfilariae avoid complement attack by direct binding of factor H". The Journal of Infectious Diseases. 185 (12): 1786–1793

Lewis RS (March 2009). "STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1". Cell. 136 (5): 876–90. doi:10.1016/j

onc.1205658. PMID 12165861. Heinrichs V, Hackl W, Lührmann R (1992). "Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear

(September 1989). "Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil

Fanburg BL, Cochran BH, Guan KL (October 2000). "Regulation of STAT3 by direct binding to the Rac1 GTPase". Science. 290 (5489): 144–7. Bibcode:2000Sci...290

PMID 2391353. Kouklis PD, Hutton E, Fuchs E (1994). "Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins". J.

heterogeneous, including RPS26 (the known DBA10 gene), TSR2 which encodes a direct binding partner of RPS26, and RPS28. The phenotype of DBA patients suggests

S2CID 25191463. Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, et al. (March 2001). "Direct binding of beta-arrestins to two distinct intracellular domains of the delta

PMID 18544533. Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, et al. (March 2001). "Direct binding of beta-arrestins to two distinct intracellular domains of the delta

conserved among ERM proteins and is responsible for membrane association by direct binding to the cytoplasmic domain or tail of integral membrane proteins. ERM

doi:10.1242/jcs.109.2.277. PMID 8838651. Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail

Fanburg BL, Cochran BH, Guan KL (October 2000). "Regulation of STAT3 by direct binding to the Rac1 GTPase". Science. 290 (5489): 144–147. Bibcode:2000Sci.

2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". The Journal of Biological

Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ (March 1993). "Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation

(November 1975). "Brain receptors for antipsychotic drugs and dopamine: direct binding assays". Proceedings of the National Academy of Sciences of the United

complement alternative pathway by Listeria monocytogenes: evidence for direct binding and proteolysis of the C3 component on bacteria". Infection and Immunity

1998). "Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1". Exp. Cell Res. 242 (2): 540–7. doi:10.1006/excr.1998.4136

1998). "Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1". Exp. Cell Res. 242 (2): 540–7. doi:10.1006/excr.1998.4136

models and imply that APC's core mechanistic functions may not require direct binding to β-catenin, but necessitate interactions with Axin. The researchers

PMID 1502153. Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG (May 2001). "Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein

Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

1016/S0378-1119(97)00411-3. PMID 9373149. Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with

MacDonald JI, Gryz EA, Kubu CJ, Verdi JM, Meakin SO (June 2000). "Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines

Tareen SU, Melville MW, Blakely CM, Katze MG (September 2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein

K, Guillier M, Leibovitch SA (June 2000). "Stabilization of MyoD by direct binding to p57(Kip2)". J. Biol. Chem. 275 (25): 18767–76. doi:10.1074/jbc.M907412199

MC, Waterman CM, Alushin GM (November 2020). "Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains". Developmental Cell. 55 (4): 468–482

mediate the effect of ethanol on ion channels in some instances and not direct binding of the free ethanol to the channel. PLD2 is a mechanosensor and directly

(June 2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165". J. Biol. Chem. 278 (26): 23656–23665

PMID 20379614. Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (April 2009). "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the

Taipale, J; Cooper, M. (2002). "Inhibition of Hedgehog Signaling by direct binding of Cyclopamine to Smoothened". Genes Dev. 16 (21): 2743–2748. doi:10

Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division"

S. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol. 1997;138(1):181-92

miR-145. NEDD9-binding regions in the miR-145 locus would allow the direct binding of the NEDD9 3'UTR to the genomic region of miR-145, and some studies

independent of any effects on transcription and can only be due to direct binding of activated glucocorticoid receptor with other proteins or with mRNA

4039406. PMC 1356129. PMID 16344560. Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling". J

Expression of Pim-1 has been shown to be regulated by the JAK/STAT pathway. Direct binding of transcription factors STAT3 and STAT5 to the Pim-1 promoter results

(2003). "Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1". Biochem. Biophys. Res. Commun

"Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain". The Journal of

(2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj

that NPC1 is the critical receptor mediating Ebola infection via its direct binding to the viral GP, and that it is the second "lysosomal" domain of NPC1

pathway. Mol. Cell. Biol. 22:578-586. Hartley, D. and Cooper, G.M. 2000. Direct binding and activation of STAT transcription factors by the herpesvirus saimiri

factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element". Molecular and

Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

migration, proliferation, differentiation, and survival. It functions by direct binding to integrin receptors, as well as other receptors such as NOTCH1 and

Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood

cells can recognize pathogens through different mechanisms including direct binding of pathogens or their components to PAMP receptors on the mast cell

PMID 9811605. S2CID 17181162. Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex

PMID 12036313. Tan SL, Tareen SU, Melville MW, et al. (2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein

activate neurotransmitter receptors either directly or indirectly. Direct-binding agonists can be further characterized as full agonists, partial agonists

cough responses. Its mechanism of action does not appear to involve direct binding to TRPA1 but rather the indirect activation and/or sensitization of

1997.5033. PMID 9441748. Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with

"Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4". Cell. 86 (4): 589–98. doi:10.1016/s0092-8674(00)80132-4

PMC 359202. PMID 7935391. Tang J, Feng GS, Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated

reduction of chromium(VI) to chromium(III). The second process includes the direct binding of chromium(V), produced by reduction in the cell, and chromium(IV)

PMC 2164984. PMID 10508865. Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with

Tareen SU, Melville MW, Blakely CM, Katze MG (September 2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein

receptor affinity for the serotonergic 5-HT1A and 5-HT2B subtypes, though direct binding to the serotonin transporter was not observed. A later study confirmed

Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G (March 2001). "Direct binding of beta-arrestins to two distinct intracellular domains of the delta

49.35179. PMID 10575001. Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

suppressor kinase LKB1 coactivates ERα in the cell nucleus through direct binding, recruiting it to the promoter of ERα-responsive genes. LKB1's catalytic

1074/mcp.M400077-MCP200. PMID 15659558. Mansharamani M, Wilson KL (2005). "Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of

C000302200. PMID 10833507. Biederer T, Südhof TC (2001). "Mints as adaptors. Direct binding to neurexins and recruitment of munc18". J. Biol. Chem. 275 (51): 39803–6

PMC 2132999. PMID 9647647. Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with

1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033. Haren L, Merdes A (2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail

PMC 15167. PMID 9892664. Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A". The Journal of Cell Biology. 184 (1): 67–82. doi:10

Castagnino P, Biesova Z, Wong WT, Fazioli F, Gill GN, Di Fiore PP (1995). "Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine- and

PMC 15167. PMID 9892664. Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

adhered to the glomerular basement membrane (GBM). Another mechanism is direct binding of antibodies to GBM antigens such as C1q, nucleosomal proteins, heparin

doi:10.1038/414865a. PMID 11780052. Meyer HH, Wang Y, Warren G (2002). "Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47

Increased expression of DDX3X by HIF1A in hypoxia is initiated by the direct binding of HIF1A to the HIF1A response element, as verified with chromatin immunoprecipitation

dithiolene coordination in the reduced enzyme form could facilitate direct binding of the S=O. In the reduction of Mo and protonation of the oxo-group

antagonist. The most common mechanism of nuclear receptor action involves direct binding of the nuclear receptor to a DNA hormone response element. This mechanism

M008453200. PMID 11010978. Biederer T, Südhof TC (2001). "Mints as adaptors. Direct binding to neurexins and recruitment of munc18". J. Biol. Chem. 275 (51): 39803–6

C100359200. PMID 11483589. Tang J, Feng GS, Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated

referred to as the non-canonical inflammasome. Caspase-11 activation by direct binding to LPS represents a novel and unprecedented mechanism for caspase activation

behavior. One function of androgen receptor that is independent of direct binding to its target DNA sequence is facilitated by recruitment via other DNA-binding

transport in migration. Another neuronal role for NSF is indicated by its direct binding to the GluR2 subunit of AMPA type glutamate receptors (which detect

S2CID 23696667. Biederer T, Südhof TC (2001). "Mints as adaptors. Direct binding to neurexins and recruitment of munc18". J. Biol. Chem. 275 (51): 39803–39806

M509590200. PMID 16291744. Liu F, Hill DE, Chernoff J (December 1996). "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the

shown. Other TRP channels that directly bind PIP2 are TRPM8 and TRPML. Direct binding does not exclude PIP2 from affecting the channel by indirect mechanisms

(2001). "Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I". Neuron. 28 (2): 449–59

Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (December 1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with

S2CID 54381509. Lee FJ, Liu F, Pristupa ZB, Niznik HB (April 2001). "Direct binding and functional coupling of alpha-synuclein to the dopamine transporters

Sugiyama Y, Tomoda K, Tanaka T, Arata Y, Yoneda-Kato N, Kato J (2001). "Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of

senescence. The p21 gene contains several p53 response elements that mediate direct binding of the p53 protein, resulting in transcriptional activation of the gene

death. HR can be activated in two main ways: directly and indirectly. Direct binding of the virulence factors to the NLRs can result in the activation of

MS, Lischetti T, Streicher W, Kragh Nielsen T, et al. (March 2013). "Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression"

directly to the androgen receptor, promoting transcriptional through direct binding to the androgen receptor FXXLF motif region. This control is specific

Roeth JF, Kasper MR, Fleis RI, Przybycin CG, Collins KL (Dec 2002). "Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility

6408. PMC 231642. PMID 8887669. Liu F, Hill DE, Chernoff J (1997). "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the

doi:10.1038/sj.cdd.4401382. PMID 14739942. Wang, G.; et al. (2005). "Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic

about gene regulation and gene stoichiometry to be answered. Beyond direct binding of dCas9 to transcriptionally sensitive positions of loci, dCas9 can

response. Indirect-acting analog causes agonistic effect but without a direct binding to the β-adrenergic receptor, for example, by promoting release of norepinephrine

overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated

Beachy, Philip A. (2002-11-01). "Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened". Genes & Development. 16 (21): 2743–2748

7492. PMID 9344857. Tang J, Feng GS, Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated

activity, since these first studies, has been determined to be due to its direct binding of DNA. More specifically, the neothramycin binds the NH2 of guanine

Hemal H; Yen, Kelvin; Cohen, Pinchas (May 2023). "Casein kinase 2 is a direct binding partner and a functional target of the exercise-mimetic microprotein

PMC 2453698. PMID 18591651. * Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex

that allow recognition of specific pathogen effectors, either through direct binding or by recognition of the effector's alteration of a host protein. Many

function in osteogenesis. These activities may be modulated by its direct binding to decorin and biglycan, two members of a family of small leucine-rich

Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the

the agr effector molecule RNAIII. PSMs, however, are controlled by direct binding of AgrA to the promoter region. PSM-mec RNA has been implicated in the

1006/mgme.1998.2698. PMID 9682218. Fang G, Yu H, Kirschner MW (1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex

Ryuichi Sakai, Keiya Ozawa, Yoshio Yazaki, Hisamaru Hirai (1996). "Direct Binding of C-terminal Region of p130Graphic to SH2 and SH3 Domains of Src Kinase"

which brings a cluster assembled on the main scaffold protein ISCU. Direct binding of HSC20 to the LYR motif of LYRM7 in a pre-assembled UQCRFS1-LYRM7

5707. PMC 232419. PMID 9315629. Tang J, Feng GS, Li W (1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated

and FtsW), and activates FtsA mediated recruitment of FtsQLB through direct binding of FtsA. However, while FtsA, FtsQLB, FtsI and FtsW are widely conserved

domains are modular and can function in proximity to each other without direct binding. This means that even though the transcription factor is split into

inhibited by a shortage of oxygen because there are yet to be any known direct binding sites for "a lack of oxygen", only whole cell and ion channel responses

chloroplast and its relationship with the SbtB protein as its inhibitor by direct binding. SbtB tends to bind to the membrane when interacting with SbtA. This

S2CID 54381509. Lee FJ, Liu F, Pristupa ZB, Niznik HB (April 2001). "Direct binding and functional coupling of alpha-synuclein to the dopamine transporters

Zhang M (July 2022). "ZG16 promotes T-cell mediated immunity through direct binding to PD-L1 in colon cancer". Biomarker Research. 10 (1): 47. doi:10

activity of androgenic progestins is mediated by two mechanisms: 1) direct binding to and activation of the androgen receptor; and 2) displacement of testosterone

PMID 23713811. Choi HY, Park N, Na JB, Ko ES, Park JY, Yoo JC (2016). "Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility

been found to play a role in erythroid cell differentiation through direct binding with GATA-1. In hematopoietic cells, ZNF521 mRNA is widely expressed

better understood the impacts of the C-terminus on viral life cycle: E1A direct binding of RubBL1 repressing gene activation induced by interferons, and Ku70

inhibition of Smad4 via ubiquitination of Lysine 519 and also though direct binding to phospho-Smad2. Injection of Ecto mRNA in the marginal zone leads

Howell BW, Goffinet A, Mumby MC, Cooper JA, et al. (October 1999). "Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation

(2005). "M. Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1". Exp. Cell Res. 242 (2): 540–547. doi:10.1006/excr.1998.4136

role of RBM4 in translation was substantiated by demonstrating its direct binding to the 3'-UTR of Period1 (Per1), a significant circadian clock gene

the intervening layers of computation. The mechanism mediating this direct binding has not been clarified but several hypotheses have been put forward

functions. For example IQGAP1 is associated with actin dynamics through direct binding of actin and indirect regulation via Cdc42/Rac1, but also modulates

STAU1-mediated mRNA decay (SMD) is an mRNA degradation process that involves direct binding of STAU1 to SBS, which is located downstream of the stop codon of the

Denker, SP. Huang, DC, Orlowski, J, Furthmayr, H and Barber, DL. 2000 Direct binding the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton

activation does not proceed through OXER1; rather, it involves the direct binding of the oxo analog to PPARγ with 5-oxo-15-(S)-hydroxy-ETE being more

also opened up the possibility that anesthetics could work through direct binding to proteins, rather than affect membrane proteins indirectly through

Wu Y, Long W, Chen CX, Hussain Z, Wang S, Chen XZ (December 2007). "Direct binding of alpha-actinin enhances TRPP3 channel activity". Journal of Neurochemistry

demonstrating that MLP can act directly on actin cytoskeleton dynamics through direct binding that stabilizes and crosslinks actin filaments into bundles. Additionally

Xu J, Spiryda LB, Park JS, Jeong KH, McGee EA, Kaiser UB (2002). "Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both

March 2015. "voxeljet AG: EuroMold premiere: 3D printing with Phenolic-Direct-Binding". FinanzNachrichten.de. Retrieved 27 November 2015. "Ford Motor setzt

PMC 2224239. PMID 18160536. Gross DA, Zhan C, Silver DL (December 2011). "Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and

the presence or absence of expression of other CAS family members. Direct binding has also been identified between CASS4 and CRKL, an SH2- and SH3 domain-containing

mediated coeliac disease. Antibody recognition of gluten is complex. Direct binding to gluten such as anti-gliadin antibodies has an ambiguous pathogenesis

binding. The regulation of ion channels by cholesterol can stem from both direct binding interactions and an indirect influence, facilitated by the localization

putative signalling pathway of TNMD is largely unknown due to unidentified direct binding partners. Many knockout mouse models with tendon phenotypes have helped

Slug are able to suppress the expression of the E-cadherin gene via direct binding to its promoter, as well as production of epithelial proteins such as

release of the transcript. RNA Polymerase II is terminated through direct binding of the 3′-end cleavage and polyadenylation (CPA) complex to the enzyme

Thomas, L; Henson, A; Reed, JC; Salsbury, FR; Thorburn, A (2004). "Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related

Berger A, Ivanova E, Gareau C, Scherrer A, Mazroui R, Strub K (2014). "Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes

12613/9243. PMID 9242628. Kirsch KH, Georgescu MM, Hanafusa H (Oct 1998). "Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G". The Journal

coordinately activates many genes involved in amino acid biosynthesis by direct binding to target sites in their promoters. He developed the first “random selection”

are known for their regulatory role in gene transcription either by direct binding to DNA or interacting with other proteins. Although RHCP1 is expressed