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searching for Cas9 221 found (326 total)

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Guide RNA (2,232 words) [view diff] exact match in snippet view article find links to article

can also be designed to be used for targeted editing, such as with CRISPR-Cas9. RNA-editing Guide RNA was discovered in 1990 by B. Blum, N. Bakalara, and
Germline mutation (2,921 words) [view diff] exact match in snippet view article find links to article
protein Cas9 to break the DNA backbones at specific target sequences. This system has shown a higher specificity than TALENs or ZFNs due to the Cas9 protein
Site-directed mutagenesis (2,868 words) [view diff] exact match in snippet view article find links to article
to site-directed mutagenesis. Since 2013, the development of the CRISPR/Cas9 technology, based on a prokaryotic viral defense system, has also allowed
Epigenome editing (2,992 words) [view diff] exact match in snippet view article find links to article
proteins, Transcription Activator-Like Effectors (TALEs) and nuclease deficient Cas9 fusions (CRISPR). Comparing genome-wide epigenetic maps with gene expression
CRISPR/Cas Tools (1,257 words) [view diff] exact match in snippet view article find links to article
D. (2017-01-10). "Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA". Journal
DNA-binding domain (2,344 words) [view diff] exact match in snippet view article find links to article
complementarity to target DNA sites. Cas9 can be used as a customizable RNA-guided DNA-binding platform. Domain Cas9 can be functionalized with regulatory
He Jiankui (4,732 words) [view diff] exact match in snippet view article find links to article
evolution, including that of CRISPR, He learned gene-editing techniques (CRISPR/Cas9) as a postdoctoral researcher at Stanford University in California. He Jiankui
Mutagenesis (molecular biology technique) (2,864 words) [view diff] exact match in snippet view article
more specific changes can be made. Since 2013, development of the CRISPR/Cas9 technology, based on a prokaryotic viral defense system, has allowed for
Andrea Crisanti (scientist) (1,068 words) [view diff] exact match in snippet view article
malaria incidence. In 2018, Crisanti and colleagues demonstrated that CRISPR/Cas9 can be programmed to attack a conserved region of the sex determination gene
De-extinction (5,113 words) [view diff] exact match in snippet view article find links to article
advancing with the help of the CRISPR/Cas systems, particularly CRISPR/Cas9. The CRISPR/Cas9 system was originally discovered as part of the bacterial immune
IRAK3 (708 words) [view diff] exact match in snippet view article find links to article
encoded by the IRAK3 gene. Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced
Trichome (2,773 words) [view diff] exact match in snippet view article find links to article
marker for plant research to improve gene editing methods such as CRISPR/Cas9. Trichomes also serve as models for cell differentiation as well as pattern
Missense mRNA (1,012 words) [view diff] exact match in snippet view article find links to article
substitutions, novel technologies that co-inject gRNA and hCas9 mRNA of the CRISPR/Cas9 system, in conjunction with single-strand oligodeoxynucleotide (ssODN) donor
Saccharomyces boulardii (1,709 words) [view diff] exact match in snippet view article find links to article
at 37 °C (98.6 °F). In addition, the popular genome-editing tool CRISPR-Cas9 was proven to be effective in S. boulardii. Boulard first isolated this yeast
Rodolphe Barrangou (475 words) [view diff] exact match in snippet view article find links to article
Advisory Board of Intellia Therapeutics. His research focuses on CRISPR-Cas9 in bacteria. In 2017, Barrangou was named Editor-in-Chief of The CRISPR Journal
Candida albicans (9,298 words) [view diff] exact match in snippet view article find links to article
knowledge on essential genes can be used to discover novel antifungals. CRISPR/Cas9 has been adapted to be used in C. albicans. Several studies have been performed
Trans-activating crRNA (403 words) [view diff] exact match in snippet view article find links to article
crRNA/tracrRNA hybrid. This hybrid acts as a guide for the endonuclease Cas9, which cleaves the invading nucleic acid. CRISPR Deltcheva E, Chylinski K
Functional genomics (3,747 words) [view diff] exact match in snippet view article find links to article
of disrupted genes can be assigned based on observed phenotypes. CRISPR-Cas9 has been used to delete genes in a multiplexed manner in cell-lines. Quantifying
Dharmacon (554 words) [view diff] exact match in snippet view article find links to article
CRISPR-Cas9 IP licensed to GE Dharmacon™ Edit-R™ Gene Engineering System | The Scientist Magazine® GE Healthcare Dharmacon Advances CRISPR Cas9 Gene Engineering
Catgrip (478 words) [view diff] exact match in snippet view article find links to article
one, two or three metal ions. An example is given by residues 586-590 of Cas9 endonuclease (pdb code 4oge) where the mainchain CO groups from residues
Anopheles (5,347 words) [view diff] exact match in snippet view article find links to article
eradicate Anopheles gambiae, the main vector for malaria, with a CRISPR-Cas9 gene drive system. This system aims to eradicate the species through introducing
Senolytic (1,448 words) [view diff] exact match in snippet view article find links to article
lysosomal β-galactosidase (a common senescence marker) Crispr/Cas9 BIRC5 Gene Knockout: Crispr/Cas9 is used to trigger apoptosis in relation to a specified
Gene knock-in (1,568 words) [view diff] exact match in snippet view article find links to article
inserted with a CRISPR/Cas9 system, which allows for much more accurate and successful gene insertions. The speed of CRISPR/Cas9-mediated gene knock-in
Transcription activator-like effector nuclease (3,140 words) [view diff] exact match in snippet view article find links to article
editing with engineered nucleases. Alongside zinc finger nucleases and CRISPR/Cas9, TALEN is a prominent tool in the field of genome editing. TAL effectors
Myostatin-related muscle hypertrophy (620 words) [view diff] exact match in snippet view article find links to article
S, et al. (December 2015). "Generation of gene-target dogs using CRISPR/Cas9 system". Journal of Molecular Cell Biology. 7 (6): 580–3. doi:10.1093/jmcb/mjv061
Duchenne muscular dystrophy (6,182 words) [view diff] exact match in snippet view article find links to article
Duchenne muscular dystrophy (DMD). Researchers used a technique called CRISPR/Cas9-mediated genome editing, which can precisely remove a mutation in the dystrophin
Lei Stanley Qi (567 words) [view diff] exact match in snippet view article find links to article
Stanford University. Qi led the development of the first catalytically dead Cas9 lacking endonuclease activity (dCas9), which is the basis for CRISPR interference
SKBR3 (361 words) [view diff] exact match in snippet view article find links to article
cancers. The cell line has also been examined for applications in CRISPR/Cas9 gene editing, antibody resistance in transfections, and HER2-based cancer
Christine Merlin (2,479 words) [view diff] exact match in snippet view article find links to article
In 2016, Merlin and colleagues demonstrated that both TALENs and CRISPR/Cas9 technologies could be utilized in a similar manner to create highly efficient
15-Cis-phytoene desaturase (896 words) [view diff] exact match in snippet view article find links to article
successful genome editing in fruit such as apples, grapes or bananas using CRISPR/Cas9 systems. In rice, the natural PDS was supplemented by its bacterial homolog
HAP1 cells (908 words) [view diff] exact match in snippet view article find links to article
the Chromosome 15 region by the endonuclease Cas9, which led to the elimination of the fragment. The Cas9 was programmed by short guide RNAs (gRNAs) to
Gene therapy (14,015 words) [view diff] exact match in snippet view article find links to article
moratorium on inheritable human genome edits, including those related to CRISPR-Cas9 technologies but that basic research including embryo gene editing should
Zinc finger nuclease (4,644 words) [view diff] exact match in snippet view article find links to article
used to precisely alter the genomes of higher organisms. Alongside CRISPR/Cas9 and TALEN, ZFN is a prominent tool in the field of genome editing. The DNA-binding
Penicillium chrysogenum (1,387 words) [view diff] exact match in snippet view article find links to article
the penicillin gene cluster. Similar to other filamentous fungi, CRISPR/Cas9-based genome editing techniques are available for editing the genome of Penicillium
Thermoascus (344 words) [view diff] exact match in snippet view article find links to article
Agrobacterium tumefaciens-mediated transformation protocol and a CRISPR-Cas9 gene editing system, which have been used to overexpress genes that correspond
Fluorine-18 (714 words) [view diff] exact match in snippet view article find links to article
PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. The dual-modality small molecule targeting
FGF8 (2,154 words) [view diff] exact match in snippet view article find links to article
been documented to play a role in oralmaxillogacial diseases and CRISPR-cas9 gene targeting on FGF8 may be key in treating these diseases. Cleft lip and/or
List of awards and honors received by Jennifer Doudna (1,591 words) [view diff] exact match in snippet view article find links to article
to biochemistry and genetics, and is most famous for her work on CRISPR-Cas9 genome editing technology. Doudna and Emmanuelle Charpentier were awarded
NIMPLY gate (136 words) [view diff] exact match in snippet view article find links to article
Fussenegger, Martin; Bojar, Daniel; Kim, Hyojin (9 April 2019). "A CRISPR/Cas9-based central processing unit to program complex logic computation in human
C11orf53 (545 words) [view diff] exact match in snippet view article find links to article
acidic conditions, which are typical of the tumor microenvironment. CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the
Molecular Infection Medicine Sweden (397 words) [view diff] exact match in snippet view article find links to article
the driving force behind the discovery of the mechanisms behind the CRISPR-Cas9 system. MIMS web page – www.mims.umu.se UCMR web page – www.ucmr.umu.se "Remote
Kiran Musunuru (1,164 words) [view diff] exact match in snippet view article find links to article
and is a leading expert in genome-editing techniques, particularly CRISPR-Cas9. His lab was the first to develop an efficient technique to genetically modify
Xenopus (6,025 words) [view diff] exact match in snippet view article find links to article
Gerald H.; Grainger, Robert M. (2013-12-01). "Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis". Genesis. 51 (12): 835–843
Genetically modified insect (2,472 words) [view diff] exact match in snippet view article find links to article
Dimitris; Gribble, Matthew; Baker, Dean; Marois, Eric (2015-12-07). "A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector
Wild-type transthyretin amyloid (1,222 words) [view diff] exact match in snippet view article find links to article
has demonstrated that NTLA-2001, a therapeutic agent based on the CRISPR-Cas9 system, induces targeted knockout of the transthyretin protein. Because of
Jung-Min Lee (849 words) [view diff] exact match in snippet view article find links to article
targeted therapy. [1] Her research has expanded to include the use of CRISPR-Cas9 mediated therapeutic editing of genes involved in disease causing such as
Transformation (genetics) (6,783 words) [view diff] case mismatch in snippet view article
mushroom strain edited with CRISPR/CAS9 to prevent fruit body browning causing a broad discussion about placing CRISPR/CAS9-edited crops on the market. Physical
Somatic cell (1,136 words) [view diff] exact match in snippet view article find links to article
103481. PMC 4434944. PMID 23153565. "Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease". Retrieved 5 July 2018. "NIH
PARP inhibitor (1,757 words) [view diff] exact match in snippet view article find links to article
Aleksandrov R, et al. (May 2018). "Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance"
HIV/AIDS research (3,697 words) [view diff] exact match in snippet view article find links to article
Inoue, Mari; Kotaki, Tomohiro; Kameoka, Masanori (17 May 2018). "CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in
Selfish genetic element (10,182 words) [view diff] exact match in snippet view article find links to article
countervailing selection, they are expected to go to fixation in a population. CRISPR-Cas9 technology allows the artificial construction of homing endonuclease systems
David M. Sabatini (1,326 words) [view diff] exact match in snippet view article find links to article
human cells, most notably through the use of RNA interference and the CRISPR-Cas9 system. As of 2016, Sabatini has authored over 250 publications and has an
HIV/AIDS research (3,697 words) [view diff] exact match in snippet view article find links to article
Inoue, Mari; Kotaki, Tomohiro; Kameoka, Masanori (17 May 2018). "CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in
Aedes aegypti (3,611 words) [view diff] exact match in snippet view article find links to article
the reproductive cycle of these animals. The recent invention of CRISPR/Cas9 based genome editing tool have significantly expanded the scope of genome
Human genetic enhancement (1,742 words) [view diff] exact match in snippet view article find links to article
using clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9, a gene editing technique, they disabled a gene called CCR5 in the embryos
Yield10 Bioscience (1,270 words) [view diff] exact match in snippet view article find links to article
acknowledging that its camelina line has had a gene disrupted using CRISPR/Cas9 gene editing technology, resulting in the desired phenotype. The use of CRISPR
Micropeptide (3,880 words) [view diff] no match in snippet view article find links to article
Micropeptides (also referred to as microproteins) are polypeptides with a length of less than 100-150 amino acids that are encoded by short open reading
Gene knockdown (1,603 words) [view diff] exact match in snippet view article find links to article
Braff JL, Moosburner M, Yaung SJ, Church GM (November 2013). "Orthogonal Cas9 proteins for RNA-guided gene regulation and editing" (PDF). Nature Methods
Embryo (3,065 words) [view diff] exact match in snippet view article find links to article
attempted - see He Jiankui affair) genetic editing of human embryos via CRISPR-Cas9 as a potential avenue for preventing disease; however, this has been met
Ralph L. Brinster (3,822 words) [view diff] exact match in snippet view article find links to article
injection strategies developed by Brinster serve as the basis for the CRISPR/Cas9 system of genetic modification currently used for all types of gene changes
Wolf Prize in Medicine (228 words) [view diff] exact match in snippet view article find links to article
Charpentier  France for deciphering and repurposing the bacterial CRISPR/Cas9 immune system for genome editing. Jennifer Doudna  United States for revealing
Eradication of suffering (1,360 words) [view diff] exact match in snippet view article find links to article
; Gould, Fred (2017-09-08). "Evaluating strategies for reversing CRISPR-Cas9 gene drives". Scientific Reports. 7 (1): 11038. Bibcode:2017NatSR...711038V
David Kirsch (427 words) [view diff] exact match in snippet view article find links to article
Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." Nature
Protein & Cell (237 words) [view diff] exact match in snippet view article find links to article
Songyang, Zhou; Ma, Wenbin; Zhou, Canquan; Huang, Junjiu (2015). "CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes". Protein & Cell. 6
MELK (975 words) [view diff] exact match in snippet view article find links to article
PMID 16266996. Lin A, Giuliano CJ, Sayles NM, Sheltzer JM (March 2017). "CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going
New England Biolabs (2,015 words) [view diff] exact match in snippet view article find links to article
agreement with ERS Genomics Limited that gave NEB rights to sell CRISPR/Cas9 tools and reagents, used for gene editing. The NEBuilder HiFi DNA Assembly
Science Olympiad (3,311 words) [view diff] exact match in snippet view article find links to article
that is being used with CRISPR Cas9 to edit plant and animal genomes. This year's event will focus on modifications to Cas9 that make it useful for base-editing
Bayside, Wisconsin (1,459 words) [view diff] exact match in snippet view article find links to article
patent holder re: Method to Bioengineer Designer Platelets using CRISPR/Cas9 and Stem Cell Methodologies "2019 U.S. Gazetteer Files". United States Census
Macular degeneration (9,453 words) [view diff] exact match in snippet view article find links to article
number of trials have occurred in humans with encouraging results. CRISPR-Cas9 genome editing may be used to treat wet age-related macular degeneration
CRISPR Therapeutics (472 words) [view diff] exact match in snippet view article find links to article
Stephan; Handgretinger, Rupert; Ho, Tony W. (21 January 2021). "CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia". New England Journal
Genetic engineering (13,744 words) [view diff] exact match in snippet view article find links to article
Jennifer Doudna and Emmanuelle Charpentier collaborated to develop the CRISPR/Cas9 system, a technique which can be used to easily and specifically alter the
Horizontal Environmental Genetic Alteration Agents (1,434 words) [view diff] exact match in snippet view article find links to article
2015). "Efficient Virus-Mediated Genome Editing in Plants Using the CRISPR/Cas9 System". Molecular Plant. 8 (8): 1288–91. doi:10.1016/j.molp.2015.02.011
Monoclonal antibody (4,566 words) [view diff] exact match in snippet view article find links to article
of recombinant monoclonal antibodies involves repertoire cloning, CRISPR/Cas9, or phage display/yeast display technologies. Recombinant antibody engineering
David R. Liu (2,398 words) [view diff] exact match in snippet view article find links to article
the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions". Nature Biotechnology. 35 (4): 371–376. doi:10
Killifish (2,130 words) [view diff] exact match in snippet view article find links to article
was achieved in Nothobranchius furzeri using a draft genome and the CRISPR/Cas9 system. By targeting multiple genes, including telomerase, the killifish
Genetically modified organism (23,894 words) [view diff] exact match in snippet view article find links to article
nucleases, transcription activator-like effector nucleases (TALENs), and the Cas9-guideRNA system (adapted from CRISPR). TALEN and CRISPR are the two most
Familial amyloid polyneuropathy (1,176 words) [view diff] exact match in snippet view article find links to article
Retrieved 11 August 2018. Gillmore, Julian D. (August 5, 2021). "CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis". The New England Journal
Triptolide (889 words) [view diff] exact match in snippet view article find links to article
McWhinnie, J. A. Tallarico, Y.Yang, Y. Feng, DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells. Nat. Chem. Biol. 2014
Gene cassette (1,314 words) [view diff] exact match in snippet view article find links to article
the uptake and expression of the new genetic elements. The usage of CRISPR/Cas9 systems has shown success in inserting genes into eukaryotic genomes. While
Retinitis pigmentosa (5,753 words) [view diff] exact match in snippet view article find links to article
study by Bakondi et al. at Cedars-Sinai Medical Center showed that CRISPR/Cas9 can be used to treat rats with the autosomal dominant form of retinitis pigmentosa
Hyperphosphatasia with mental retardation syndrome (591 words) [view diff] exact match in snippet view article find links to article
Stumpf A, Pitsch J, Tsortouktzidis D, et al. (January 2021). "A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes
NAS Award in Molecular Biology (1,692 words) [view diff] exact match in snippet view article find links to article
systems, groundbreaking work that catalyzed the manipulation of the CRISPR-Cas9 pathway for genome engineering. Dianne K. Newman (2016) For her discovery
Vienna Biocenter (419 words) [view diff] exact match in snippet view article find links to article
Charpentier and Jennifer Doudna for their groundbreaking discoveries on the CRISPR/Cas9 system. Emmanuelle Charpentier was a principal investigator at the Max Perutz
Myostatin (4,949 words) [view diff] exact match in snippet view article find links to article
significantly over-represented in the top racing classes. In 2016, the CRISPR/Cas9 system was used to genetically engineer rabbits and goats with no functional
Natalia Gomez-Ospina (817 words) [view diff] exact match in snippet view article find links to article
Yan, Shuqi; Camarena, Joab; Lee, Ciaran M. (Aug 2018). "A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing
HacDC (530 words) [view diff] exact match in snippet view article find links to article
Gentle Hacker's Literary Salon RepRap 3D printer [1] HacDC Spaceblimp CRISPR-Cas9 bacterial gene editing project. Scanning electron microscope refurbishment
Broad Institute (1,985 words) [view diff] exact match in snippet view article find links to article
inventor of DNA-templated synthesis, phage-assisted directed evolution and Cas9/CRISPR base-editing. Aviv Regev is a computational biologist with interests
NAS Award in Chemical Sciences (1,259 words) [view diff] exact match in snippet view article find links to article
the technology for efficient site-specific genome engineering using CRISPR/Cas9 nucleases. Armand Paul Alivisatos (2017) For making fundamental contributions
David and Lucile Packard Foundation (790 words) [view diff] exact match in snippet view article find links to article
Fellows' work has contributed to breakthroughs like the creation of the CRISPR-Cas9 gene-editing technique, the discovery of soft tissues in dinosaur fossils
Timeline of biology and organic chemistry (2,719 words) [view diff] exact match in snippet view article find links to article
the most popular high-throughput sequencing system. 2012 – Use of CRISPR-Cas9 as a DNA-editing biotechnology tool. Timeline of medicine and medical technology
Opisthorchiasis (1,974 words) [view diff] exact match in snippet view article find links to article
31 (6): 1156–63. doi:10.4269/ajtmh.1982.31.1156. PMID 6983303. "CRISPR/Cas9 shown to limit impact of certain parasitic diseases". www.bionity.com. Retrieved
Timeline of biology and organic chemistry (2,719 words) [view diff] exact match in snippet view article find links to article
the most popular high-throughput sequencing system. 2012 – Use of CRISPR-Cas9 as a DNA-editing biotechnology tool. Timeline of medicine and medical technology
Theodore Roosevelt High School (Iowa) (1,316 words) [view diff] exact match in snippet view article
MIT neurobiologist, co-inventor of optogenetics, developer of the CRISPR/Cas9 gene editing method, winner of the Perl-UNC Neuroscience Prize John Swanda
Horizon Discovery (1,063 words) [view diff] exact match in snippet view article find links to article
projects. CRISPR/Cas9 is an RNA-guided gene-editing platform derived from Streptococcus pyogenes that makes use of an endonuclease (Cas9) and a synthetic
Transcriptome instability (360 words) [view diff] exact match in snippet view article find links to article
splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing". Blood Cells, Molecules and Diseases. 69: 10–22. doi:10.1016/j
Arabidopsis thaliana (7,264 words) [view diff] exact match in snippet view article find links to article
marker for plant research to improve gene editing methods such as CRISPR/Cas9. In 2005, scientists at Purdue University proposed that A. thaliana possessed
Non-fungible token (5,939 words) [view diff] exact match in snippet view article find links to article
for the patent disclosures for two Nobel Prize-winning inventions: CRISPR-Cas9 gene editing and cancer immunotherapy. The university will continue to own
Diamondback moth (4,266 words) [view diff] exact match in snippet view article find links to article
precise research to identify suitable genetic targets. Using the CRISPR/Cas9 system as a targeted gene to identify the abdominal segment, thus removing
Har Gobind Khorana (2,310 words) [view diff] exact match in snippet view article find links to article
referred to his research while advancing genome editing with the CRISPR/Cas9 system. He extended the above to long DNA polymers using non-aqueous chemistry
Maneesha S. Inamdar (1,370 words) [view diff] case mismatch in snippet view article find links to article
knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-39". Stem Cell Research. 16 (2):
Kathy Niakan (511 words) [view diff] exact match in snippet view article find links to article
healthy embryo. In 2017 her lab published the first major study using CRISPR-Cas9 in human embryos in Nature, demonstrating that the transcription factor Oct4
Max Planck Institute for Infection Biology (1,008 words) [view diff] exact match in snippet view article find links to article
nobelprize.org. Retrieved 7 October 2020. "Emmanuelle Charpentier, CRISPR-Cas9, Max Planck Institute for Infection Biology". Max Planck Unit for the Science
FGF5 (2,274 words) [view diff] exact match in snippet view article find links to article
Qu L, Chen Y (2016). "Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers". PLOS ONE. 11
Research Science Institute (1,326 words) [view diff] exact match in snippet view article find links to article
Institute and MIT neurobiologist, optogenetics pioneer, developer of the CRISPR/Cas9 gene editing method, and "35 Innovators Under 35" laureate Feng Zhang attended
Essential gene (8,351 words) [view diff] exact match in snippet view article find links to article
lead to erroneous annotations (here: false negatives). Comparison of CRISPR/cas9 and RNAi screens. Screens to identify essential genes in the human chronic
SPATA16 (461 words) [view diff] exact match in snippet view article find links to article
Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models". International Journal of Molecular Sciences. 18 (10):
Choroideremia (3,072 words) [view diff] exact match in snippet view article find links to article
safety issues related to the transplanted tissue." A 2015 study used CRISPR/Cas9 to repair mutations in patient-derived induced pluripotent stem cells that
Hilo High School (1,469 words) [view diff] exact match in snippet view article find links to article
Author of Rich Dad, Poor Dad Jennifer Doudna (1981), developer of the CRISPR-Cas9 genome editing method. Recipient of the 2020 Nobel Prize in Chemistry. Doudna
GENCODE (2,628 words) [view diff] exact match in snippet view article find links to article
2018, one of the latest additions to the GENCODE project was the CRISPR/Cas9 track on human and model organism assemblies. CRISPR is a genome editing
Cystic fibrosis (15,812 words) [view diff] exact match in snippet view article find links to article
unusable. There has been a functional repair in culture of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Phage therapy
Kang Zhang (2,561 words) [view diff] exact match in snippet view article find links to article
Zhang K, Belmonte JC (December 2016). "In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration". Nature. 540 (7631):
Late endosomal/lysosomal adaptor, mapk and mtor activator 1 (538 words) [view diff] exact match in snippet view article find links to article
2017). "Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel
Sickle cell disease (13,550 words) [view diff] exact match in snippet view article find links to article
more people being treated since then. Gene editing platforms like CRISPR/Cas9 have been used to correct the disease-causing mutation in hematopoietic stem
Adenoviridae (5,135 words) [view diff] exact match in snippet view article find links to article
M1-specific CD8+ T lymphocytes. Adenovirus has been used for delivery of CRISPR/Cas9 gene editing systems, but high immune reactivity to viral infection has posed
Amyloidosis (4,336 words) [view diff] exact match in snippet view article find links to article
E.; Leonard, John; Sepp-Lorenzino, Laura; Lebwohl, David (2021). "CRISPR-Cas9 in Vivo Gene Editing for Transthyretin Amyloidosis". New England Journal
Organoid (6,861 words) [view diff] exact match in snippet view article find links to article
intestinal cystic fibrosis organoid phenotype could be repaired by CRISPR-Cas9 gene editing in 2013. Follow-up studies by Dekkers et al. in 2016 revealed
Karmella Haynes (1,698 words) [view diff] exact match in snippet view article find links to article
pericentric reporter (94 citations) The impact of chromatin dynamics on Cas9-mediated genome editing in human cells (82 citations) Engineering bacteria
Medical genetics (5,014 words) [view diff] exact match in snippet view article find links to article
Zhou; Ma, Wenbin; Zhou, Canquan; Huang, Junjiu (18 April 2015). "CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes". Protein & Cell. 6
Chimeric antigen receptor T cell (6,465 words) [view diff] exact match in snippet view article find links to article
to a partial deletion of the U3 region. The new gene editing tool CRISPR/Cas9 has recently been used instead of retroviral vectors to integrate the CAR
Diatom (11,019 words) [view diff] exact match in snippet view article find links to article
(16 February 2018). "An Expanded Plasmid-Based Genetic Toolbox Enables Cas9 Genome Editing and Stable Maintenance of Synthetic Pathways in Phaeodactylum
Jian-Kang Zhu (2,363 words) [view diff] exact match in snippet view article find links to article
Plant Biol. 6:441-445. Miki D, Zhang W, Zeng W, Feng Z, Zhu JK. 2018. CRISPR/Cas9-mediated gene targeting in Arabidopsis using sequential transformation. Nature
5-Hydroxymethylcytosine (1,744 words) [view diff] exact match in snippet view article find links to article
June 2015). "Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9". mBio. 6 (3): e00648. doi:10.1128/mBio.00648-15. PMC 4471564. PMID 26081634
MAGESTIC (636 words) [view diff] exact match in snippet view article find links to article
specific variants to be tracked in pools, similar to how Genome-wide CRISPR-Cas9 knockout screens work, only MAGESTIC is more verstile as it allows for not
KBM-7 cells (684 words) [view diff] exact match in snippet view article find links to article
Patrick; et al. (December 2014). "Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line". Genome Research. 24 (12): 2059–206
Japan Prize (710 words) [view diff] exact match in snippet view article find links to article
Interspaced Short Palindromic Repeats)-Cas and the creation of the CRISPR-Cas9 genome editing system, a truly revolutionary technique in genetic engineering
Harvey Prize (3,023 words) [view diff] exact match in snippet view article find links to article
Doudna, U.S. and Feng Zhang, U.S. – "for leading the development of CRISPR-Cas9 technology, a breakthrough in genetic modification." 2018 – Christos H. Papadimitriou
Emerging technologies (4,824 words) [view diff] exact match in snippet view article find links to article
Justin S; Handgretinger, Rupert; Mezger, Markus (20 May 2020). "CRISPR/Cas9 technology: towards a new generation of improved CAR-T cells for anticancer
Michel Sadelain (2,269 words) [view diff] exact match in snippet view article find links to article
Sadelain, Michel (2017–03). "Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection" Nature. 543 (7643): 113–117. doi:10.1038/nature21405
Tang Prize (1,090 words) [view diff] exact match in snippet view article find links to article
Biopharmaceutical Science Emmanuelle Charpentier  France "for the development of CRISPR/Cas9 as a breakthrough genome editing platform that promises to revolutionize
DNA repair (13,771 words) [view diff] exact match in snippet view article find links to article
clustered regularly interspaced short palindromic repeat (shortened to CRISPR-Cas9) was discovered in 2012. The new technology allows anyone with molecular
Tang Prize (1,090 words) [view diff] exact match in snippet view article find links to article
Biopharmaceutical Science Emmanuelle Charpentier  France "for the development of CRISPR/Cas9 as a breakthrough genome editing platform that promises to revolutionize
Genetically modified virus (3,891 words) [view diff] exact match in snippet view article find links to article
Zhang F (April 2015). "In vivo genome editing using Staphylococcus aureus Cas9". Nature. 520 (7546): 186–91. Bibcode:2015Natur.520..186R. doi:10.1038/nature14299
Biohub (1,269 words) [view diff] exact match in snippet view article find links to article
Science Advisory Group. Dr. Doudna is known for her pioneering work on CRISPR-Cas9, a gene-editing technology that has the potential to revolutionize genetics
Shoukhrat Mitalipov (805 words) [view diff] exact match in snippet view article find links to article
attempt at genetically correcting mutant human embryos, using the CRISPR/Cas9 gene modifying tool. Mitalipov and his team experimented upon a larger number
Eugenics (9,461 words) [view diff] exact match in snippet view article find links to article
Alex; Hornblower, Breton; Robb, Brett; Tzertzinis, George (2014). "CRISPR/Cas9 and Targeted Genome Editing: A New Era in Molecular Biology". NEB Expressions
Genetics (9,651 words) [view diff] exact match in snippet view article find links to article
Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, et al. (May 2015). "CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes". Protein & Cell. 6
Joyce Van Eck (341 words) [view diff] exact match in snippet view article find links to article
promoted to Assistant Professor. Van Eck was responsible for the first use of Cas9 for genome editing in tomato. She used a similar genome editing approach
Capitella teleta (4,580 words) [view diff] exact match in snippet view article find links to article
of gene perturbation techniques such as Morpholino knockdown and CRISPR-Cas9 mutagenesis, and methods for living imaging such as mRNA injection. The development
Evolution of the brain (4,749 words) [view diff] exact match in snippet view article find links to article
archaic gene variant NOVA1 present in Neanderthals and Denisovans via CRISPR-Cas9 shows that it has a major impact on neurodevelopment and that such genetic
UCK2 (2,384 words) [view diff] exact match in snippet view article find links to article
Carette JE, Khosla C, Bassik MC (May 2016). "Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification". Nature Chemical Biology
Gene (11,219 words) [view diff] exact match in snippet view article find links to article
Scott DA, Zhang F (November 2013). "Genome engineering using the CRISPR-Cas9 system". Nature Protocols. 8 (11): 2281–2308. doi:10.1038/nprot.2013.143
Nannochloropsis (2,925 words) [view diff] exact match in snippet view article find links to article
percentages in Nannochloropsis gaditana through applications of the CRISPR-Cas9 reverse-genetics pipeline and nitrogen starving—improving partitioning of
Xiaoliang Sunney Xie (1,956 words) [view diff] exact match in snippet view article find links to article
Wensheng; Xie, X. Sunney (2017). "Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging". Cell Res. 27 (2): 298–301. doi:10.1038/cr.2017.9
Domestic pig (7,557 words) [view diff] exact match in snippet view article find links to article
have been engineered to inactivate all 62 PERVs in the genome using CRISPR Cas9 genome editing technology, and eliminated infection from the pig to human
Mitochondrial calcium uniporter (677 words) [view diff] exact match in snippet view article find links to article
mitochondrial calcium uniporter complex resumes. Research using a CRISPR/Cas9 technique has found that MICU1 and MICU2 play other roles as well. They are
Mosquito control (5,080 words) [view diff] exact match in snippet view article find links to article
Roberto; Hammond, Andrew M.; Kyrou, Kyros (24 September 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in
Mosquito (12,571 words) [view diff] exact match in snippet view article find links to article
Environment, Retrieved 11 June 2014 Kyros Kyrou; et al. (Sep 24, 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in
Schistosomiasis (6,447 words) [view diff] exact match in snippet view article find links to article
e0006968. doi:10.1371/journal.pntd.0006968. PMC 6300301. PMID 30532268. "CRISPR/Cas9 shown to limit impact of certain parasitic diseases". www.bionity.com. Retrieved
Glutamate carboxypeptidase II (3,948 words) [view diff] exact match in snippet view article find links to article
PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. PSMA can also be used experimentally
Association of Biomolecular Resource Facilities (1,817 words) [view diff] exact match in snippet view article find links to article
Emmanuelle Charpentier and Jennifer Doudna for the development of CRISPR/Cas9 Genome Editing Technologies. 2015 John G. White and William Bradshaw Amos
Human Frontier Science Program (1,740 words) [view diff] exact match in snippet view article find links to article
(University of California, Berkeley, USA), "for their seminal work on the CRISPR-Cas9 system". 2017 David Julius (University of California, San Francisco, USA)
Alternative splicing (7,924 words) [view diff] exact match in snippet view article find links to article
splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing". Blood Cells, Molecules & Diseases. 69: 10–22. doi:10.1016/j
Huntington's disease (13,326 words) [view diff] exact match in snippet view article find links to article
genome with the erroneous gene that causes HD, using tools such as CRISPR/Cas9. Another strategy to reduce the level of mutant huntingtin is to increase
Surveyor nuclease assay (3,170 words) [view diff] exact match in snippet view article find links to article
transcription activator-like effector nucleases (TALENs) and the RNA-guided CRISPR/Cas9 nuclease system. These methods promote genome editing by introduction of
Boron (10,841 words) [view diff] exact match in snippet view article find links to article
PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. The dual-modality small molecule targeting
Behavioural genetics (7,656 words) [view diff] exact match in snippet view article find links to article
knockouts, floxing, gene knockdown, or genome editing using methods like CRISPR-Cas9. These techniques allow behavioural geneticists different levels of control
XL-413 (242 words) [view diff] exact match in snippet view article find links to article
Wyman SK, et al. (April 2020). "Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair". Nature Communications. 11 (1): 2109. Bibcode:2020NatCo
Amyotrophic lateral sclerosis research (2,123 words) [view diff] exact match in snippet view article find links to article
motor cells can be grown, and the gene expression is controlled. CRISPR/Cas9 technique can be used to knock-out/in genes that are related to ALS, and
RACGAP1 (1,641 words) [view diff] exact match in snippet view article find links to article
biogenesis in breast cancer. Knocking out RACGAP1 in vitro using CRISPR/Cas9 leads to cytokinesis failure. RACGAP1 has been shown to interact with Rnd2
Caenorhabditis elegans (8,986 words) [view diff] exact match in snippet view article find links to article
C. elegans adult with GFP coding sequence inserted into a histone-encoding gene by Cas9-triggered homologous recombination
Preclinical imaging (6,073 words) [view diff] exact match in snippet view article find links to article
PET and fluorescence imaging of genome modified cells, e.g. cancer, CRISPR/Cas9, or CAR T-cells, in an entire mouse. The combining of these imaging modalities
James Wilson (scientist) (687 words) [view diff] exact match in snippet view article
Xu, Chenyu; Morizono, Hiroki (March 2016). "A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice". Nature
Taosheng Huang (1,846 words) [view diff] exact match in snippet view article find links to article
human diseases, and has used induced pluripotent stem cell models and CRISPR/Cas9-produced mouse models in his lab to explore the pathogenesis of mutations
University of Texas Southwestern Medical Center (4,548 words) [view diff] exact match in snippet view article find links to article
damage suffered following a heart attack. Olson's lab has also used CRISPR/Cas9 methods to cure Duchenne muscular dystrophy in mice as a proof of principle
Jian Ma (computer scientist) (611 words) [view diff] exact match in snippet view article
and Tsai SQ. CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity. Nature Biotechnology, 38(11):1317-1327, 2020. Xiong
Malaria (19,552 words) [view diff] exact match in snippet view article find links to article
Fazekas A, Macias VM, Bier E, James AA (December 2015). "Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito
STING-associated vasculopathy with onset in infancy (652 words) [view diff] case mismatch in snippet view article find links to article
Louis created a mouse model of SAVI. Dr. Miner's research team used CRISPR-CAS9 genome editing to introduce a mutation into the mouse STING gene (TMEM173)
Stra8 (678 words) [view diff] exact match in snippet view article find links to article
Research done by Yani Zhang, Yingjie Wang, Qisheng Zuo, and Dong Li found that Cas9/gRNA resulted in a knockout of the Stra8 gene performed in chicken’s cells
Genetically modified crops (15,591 words) [view diff] exact match in snippet view article find links to article
Bi H, Fromm M, Yang B, Weeks DP (November 2013). "Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum
Mouse models of breast cancer metastasis (5,910 words) [view diff] exact match in snippet view article find links to article
associated with a cancer critical gene p53 which was determined via CRISPR-Cas9. The quantitative lineage-tracing strategies have proven to be successful
Md. Tofazzal Islam (3,539 words) [view diff] exact match in snippet view article find links to article
technology. He has also developed blast resistant wheat varieties using CRISPR-Cas9 genome editing and also molecular breeding through introgression of two blast
Aviation biofuel (4,160 words) [view diff] exact match in snippet view article find links to article
(October 18, 2016). "Genome editing of Clostridium autoethanogenum using CRISPR/Cas9". Biotechnology for Biofuels. 9 (1): 219. doi:10.1186/s13068-016-0638-3.
Mitochondrial replacement therapy (4,463 words) [view diff] exact match in snippet view article find links to article
Genetic Disease". Wall Street Journal. Fogleman, Sarah (2016-09-20). "CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical
Anatoly B. Kolomeisky (975 words) [view diff] exact match in snippet view article find links to article
Anatoly B. (2017). "Mechanism of Genome Interrogation: How CRISPR RNA-Guided Cas9 Proteins Locate Specific Targets on DNA". Biophysical Journal. Elsevier BV
Aaron Traywick (1,436 words) [view diff] exact match in snippet view article find links to article
Futurism. January 15, 2017. Retrieved May 6, 2018. "The Power of Crispr Cas9 & How to Create a Clearer Truth w/Aaron Traywick - TOT Revolution". TOT Revolution
W. Mark Saltzman (1,295 words) [view diff] exact match in snippet view article find links to article
"Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9". Circulation Research. 117 (2): 121–8. doi:10.1161/CIRCRESAHA.117.306290
Xenotransplantation (6,780 words) [view diff] exact match in snippet view article find links to article
have been engineered to inactivate all 62 PERVs in the genome using CRISPR Cas9 genome editing technology, and eliminated infection from the pig to human
DNA (cytosine-5)-methyltransferase 3A (2,726 words) [view diff] exact match in snippet view article
splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing". Blood Cells, Molecules and Diseases. 69: 10–22. doi:10.1016/j
Starmus Festival (3,554 words) [view diff] exact match in snippet view article find links to article
microbiologist and biochemist Emmanuelle Charpentier who talked about CRISPR-Cas9, a gene editing technology that revolutionises life sciences, biochemist
Genetically modified food (12,043 words) [view diff] exact match in snippet view article find links to article
nucleases, transcription activator-like effector nucleases (TALENs), and the Cas9-guideRNA system (adapted from CRISPR). TALEN and CRISPR are the two most
Nuclear organization (4,176 words) [view diff] exact match in snippet view article find links to article
At the same time, progress in genome-editing techniques (such as CRISPR/Cas9, ZFNs, and TALENs) have made it easier to test the organizational function
Timeline of Monsanto (711 words) [view diff] exact match in snippet view article find links to article
$56 billion. 2016 Products Monsanto buys a license from Broad Institute of Harvard University and MIT to use the CRISPR/Cas9 gene-editing technology.
Glypican (2,310 words) [view diff] exact match in snippet view article find links to article
GPC2 as a therapeutic target in neuroblastoma. Silencing of GPC2 by CRISPR/Cas9 results in the inhibition of neuroblastoma tumor cell growth. GPC2 silencing
Kathy Feng-Yi Su (861 words) [view diff] exact match in snippet view article find links to article
Gowri; Supeinthiran, Ahiraa; Meier, Rudolf; Su, Kathy F.Y. (2018). "CRISPR/Cas9 deletions in a conserved exon of Distal-less generates gains and losses in
Synthetic biology (11,312 words) [view diff] exact match in snippet view article find links to article
Charpentier and Doudna labs publish in Science the programming of CRISPR-Cas9 bacterial immunity for targeting DNA cleavage. This technology greatly simplified
AI-10-49 (1,524 words) [view diff] exact match in snippet view article find links to article
Deletion of the RUNX1 binding site in these enhancers by genome editing (CRISPR/Cas9) reduced MYC transcript levels and the viability of inv(16) AML cells, indicating
Margaret Goodell (1,022 words) [view diff] exact match in snippet view article find links to article
Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9". Cell Reports. 17 (5): 1453–1461. doi:10.1016/j.celrep.2016.09.092. PMC 5087995
Vera Meyer (996 words) [view diff] exact match in snippet view article find links to article
synthetic biology and systems biology. Gene technology methods, such as CRISPR-Cas9 and the generation of huge omics data pertaining to Aspergillus niger, are
2015 in science (23,564 words) [view diff] exact match in snippet view article find links to article
moratorium on inheritable human genome edits, including those related to CRISPR-Cas9 technologies. 4 December The Earth Institute at Columbia University publishes
Facioscapulohumeral muscular dystrophy (12,807 words) [view diff] exact match in snippet view article find links to article
alteration of genetic code, is being researched. One study tried to use CRISPER-Cas9 to knockout the polyadenylation signal in lab dish models, but was unable
Major histocompatibility complex, class I-related (1,682 words) [view diff] exact match in snippet view article find links to article
Caillaud ME, Lloyd A, Attaf M, et al. (February 2020). "Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic
Jacques Pouysségur (1,358 words) [view diff] exact match in snippet view article find links to article
Numerous anti-cancer targets inactivated by Zinc Finger Nucleases and/or CRISPR-Cas9 (carbonic anhydrases CA9, CA12, CA2, bicarbonate carriers NBC, lactate/H+
Tissue engineering (12,527 words) [view diff] exact match in snippet view article find links to article
Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System". Stem Cell Reviews and Reports. 11 (5): 774–87. doi:10.1007/s12015-015-9600-1
SaPI (1,424 words) [view diff] exact match in snippet view article find links to article
addition, by cloning, of antibacterial genes including those encoding CRISPR/cas9 with spacers targeting conserved chromosomal genes. These cause a lethal
John P. Morrissey (biologist) (1,459 words) [view diff] exact match in snippet view article
Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid. FEMS Yeast Researc 18 (3), 2018; S. foy012. doi:10
List of genetically modified crops (2,041 words) [view diff] exact match in snippet view article find links to article
Ming; Gilbert, Brian; Ayliffe, Michael (2016-07-01). "Applications of CRISPR/Cas9 technology for targeted mutagenesis, gene replacement and stacking of genes
Development, Growth & Differentiation (291 words) [view diff] exact match in snippet view article find links to article
Rapid and efficient generation of GFP-knocked-in Drosophila by the CRISPR-Cas9-mediated genome editing. 2019 Takebayashi-Suzuki, Kimiko, Konishi, H., Miyamoto
Westlake University (1,771 words) [view diff] exact match in snippet view article find links to article
services including animal breeding (mice and rats), rederivation, Tg or Cas9-mediated gene KO/KI/CKO by microinjection, IVF for rescue and expansion,
Single cell sequencing (7,747 words) [view diff] exact match in snippet view article find links to article
Bar-Joseph Z (June 2020). "Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data". Nature Communications. 3055 (1): 3055
Endocrine disruptor (15,829 words) [view diff] exact match in snippet view article find links to article
(thousands of lines) of rodents. The most recent tool used to do this is CRISPR/Cas9 which allows this process to be done more efficiently. Genes may be manipulated
Microbubble (3,800 words) [view diff] exact match in snippet view article find links to article
Yi, Yuping; Bao, Shan (May 2019). "Ultrasound microbubble-mediated CRISPR/Cas9 knockout of C-erbB-2 in HEC-1A cells". Journal of International Medical Research
Marine protists (10,408 words) [view diff] exact match in snippet view article find links to article
Amit Kumar; Sparstad, Torfinn; Bones, Atle M.; Winge, Per (2016). "A CRISPR/Cas9 system adapted for gene editing in marine algae". Scientific Reports. 6:
LMNA-related congenital muscular dystrophy (567 words) [view diff] exact match in snippet view article find links to article
the disease could be found through some advanced therapies such as CRISPR/Cas9. Muscular dystrophy Carboni N, Politano L, Floris M, Mateddu A, Solla E,
BLESS (1,968 words) [view diff] exact match in snippet view article find links to article
be artificially induced using genome editing technologies such as CRISPR-Cas9 or TALEN. These technologies may lead to unintentional modifications of DNA
Pharmacoepigenetics (4,114 words) [view diff] exact match in snippet view article find links to article
assess potential synthetic lethal interactions is using siRNA and CRISPR-Cas9 to modify target genes. CRISPRi and CRISPRa technology allows researchers
S. Matthew Liao (3,229 words) [view diff] exact match in snippet view article find links to article
raised by advances in reproductive technology, such as the use of CRISPR-Cas9 for germline gene editing, ‘three-parent IVF’ or mitochondrial replacement
Live single-cell imaging (2,110 words) [view diff] exact match in snippet view article find links to article
Conner, David A.; Hu, Johnny H.; Seidman, Christine E. (2018-01-24). "CRISPR/Cas9 Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent
SARM1 (3,886 words) [view diff] exact match in snippet view article find links to article
(2021-08-25). "Next generation SARM1 knockout and epitope tagged CRISPR-Cas9-generated isogenic mice reveal that SARM1 does not participate in regulating
Mendel Lectures (853 words) [view diff] exact match in snippet view article find links to article
Charpentier Max Planck Institute for Infection Biology, Berlin, Germany "CRISPR-Cas9: a Bacterial Immune System Repurposed as a Transformative Genome Engineering
Functional cloning (2,994 words) [view diff] exact match in snippet view article find links to article
Bangmei; Jin, Shunqian; Reiser, Michelle; Lockey, Richard F (2015). "CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning". BioTechniques
History of research on Arabidopsis thaliana (3,389 words) [view diff] exact match in snippet view article find links to article
genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9". Nature Biotechnology. 31 (8): 688–691. doi:10.1038/nbt.2654. ISSN 1087-0156
VPS35 (4,037 words) [view diff] exact match in snippet view article find links to article
modulate VPS35 using viral vectors or genome editing techniques like CRISPR/Cas9, however, given VPS35's ubiquitous role in many homeostatic processes, strict
2018 in science (22,164 words) [view diff] exact match in snippet view article find links to article
University and the Chinese Academy of Sciences report the use of CRISPR/Cas9 to develop a variety of rice producing 25-31% more grain than traditional
Sheila Singh (2,559 words) [view diff] exact match in snippet view article find links to article
Preclinical development and evaluation of CAR-T cells targeting CD70. CRISPR-Cas9 genetic screening to identify targets that act to increase sensitivity of
Murine respirovirus (27,870 words) [view diff] exact match in snippet view article find links to article
to process F0. Sendai virus based vector system that can deliver CRISPR/Cas9 for efficient gene editing was created. A set of different recombinant SeV
Clinical metagenomic sequencing (5,187 words) [view diff] exact match in snippet view article find links to article
mtRNA, globin mRNA) using sequence-specific RNA depletion kits. Also CRISPR-Cas9-based approaches can be performed to target and deplete human mitochrondrial
Arabinogalactan protein (8,922 words) [view diff] exact match in snippet view article find links to article
Marco (2017-09-22). "Efficient generation of mutations mediated by CRISPR/Cas9 in the hairy root transformation system of Brassica carinata". PLOS ONE.
List of single cell omics methods (4,717 words) [view diff] exact match in snippet view article find links to article
"Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars". Nature Biotechnology. 36 (5): 469–473. doi:10.1038/nbt
CSNK1D (14,714 words) [view diff] exact match in snippet view article find links to article
Gluenz E, Späth GF, Rachidi N (2017). "Leishmania donovani Using the CRISPR Cas9 Toolkit". BioMed Research International. 2017: 4635605. doi:10.1155/2017/4635605
RNA-directed DNA methylation (14,790 words) [view diff] exact match in snippet view article find links to article
(February 2019). "Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems". Nature Communications. 10 (1): 729. Bibcode:2019NatCo..10
July–September 2020 in science (19,645 words) [view diff] exact match in snippet view article find links to article
deleting gene drives introduced into populations in the wild with CRISPR-Cas9 gene editing. The paper's senior author cautions that the two neutralizing