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Longer titles found: Dimerization of catharanthine and vindoline (view), Jun dimerization protein (view), Telomerization (dimerization) (view), Chemically induced dimerization (view), Carbene dimerization (view), Mga, max dimerization protein (view)

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first-in-class of a kind of drug called a "HER dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents

others. It belongs to the class of tetrahydroisoquinoline alkaloids. Dimerization of coclaurine leads to the biscoclaurine alkaloids such as cepharanthine

C181, the last residue of the stalk region in CD8A, is critical for the dimerization, since it forms an inter-subunit disulfide bond. In CD8αα dimers, it

process. Several useful structural isomers of the octenes are obtained by dimerization of isobutene and 1-butene. These branched alkenes are used to alkylate

interact less, and there is a lower thermodynamic drive for dimerization. In the dimerization reactions, the diene and dienophile were equally electron

1765-1772, INIST 9467908 Ellagitannin biosynthesis: laccase-catalyzed dimerization of tellimagrandin II to cornusiin E in Tellima grandiflora. Phytochemistry

effects on protein expression. The receptors are generally activated by dimerization and substrate presentation. Receptor tyrosine kinases are part of the

CH3CH2, R' = CH3, and R" = H. Such reactions are called aldol aldol dimerization. With a mixture of carbonyl precursors, complicated mixtures can occur

of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding

preparations of anol failed to confirm these findings, and it was found that dimerization of anol into dianol and hexestrol can rapidly occur and that the latter

10-amino-acid-long dimerization arm is unable to mediate monomer-monomer interactions. In contrast, in ligand-bound ErbB-1 and unliganded ErbB-2, the dimerization arm

the primary dimer initiation site (DIS) as it is believed to promote dimerization of the viral genome through formation of a "kissing dimer" intermediate

result of the initial dimerization of two cyclobutadienes which preferably forms the syn product, shown below. The further dimerization only produces the

explosives (4,4’-dinitro-3,3’-diazenofuroxan). Furoxanes can be formed by dimerization of nitrile oxides. Clara Cena; Massimo Bertinaria; Donatella Boschi;

chemotherapeutic because of their high degree of toxicity to proliferating cells. Dimerization consists of the bonding of two monomers to form an oligomer, such as

when dimerization is a major side reaction. The success of the reaction is often determined by the relative rates of cycloaddition and dimerization of the

responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak

Milatovich A, Mendel DB, Crabtree GR, Francke U (April 1993). "Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and

as a precursor to specialty polymers. It arises commercially by the dimerization of butadiene in the presence of hydrogen. Some of the 1,6-octadiene is

preventing dimerization and resulting in the formation of translationally inactive monomeric 70S ribosomes. In addition to ribosome dimerization, the joining

polypeptides contains a two domains: a DNA-binding domain and a dimerization domain. The dimerization domain binds to other LexA polypeptides to form dumbbell

bind Zn2+ ions - and domains that facilitate dimerization of Zinc binding domains. It is this dimerization that allows catalysis to occur, since aminoacylase's

C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets

Ethylene (IUPAC name: ethene) is a hydrocarbon which has the formula C2H4 or H2C=CH2. It is a colourless, flammable gas with a faint "sweet and musky"

use of peroxydisulfuric acid gives rise to 1,4‑benzoxazine compounds. Dimerization of isatin with KBH4 in methanol yields Indirubin. This represents the

molecules of the Meldrum's acid are believed to undergo a reductive dimerization to give an alkene linkage with one "Meldrum's acid" ring on each end

clarified that dimerization is not strictly required for ADAR1 enzymatic activity. A recent study demonstrated that ADAR1 dimerization occurs specifically

colorless liquid with a strong odor. 1,5-Cyclooctadiene can be prepared by dimerization of butadiene in the presence of a nickel catalyst, a coproduct being

domain, Dimerization domain, and the Core domain which all play a specific role in the protein's structure and functionality. The dimerization domain contains

to less-substituted cyclopentadiene derivatives, Cp*H is not prone to dimerization. Pentamethylcyclopentadiene is commercially available. It was first prepared

ErbB3 that causes the protrusion of the dimerization loop in subdomain II, activating the protein for dimerization. ErbB3 has been shown to bind the ligands

and antiproliferative roles of interferons. RNase L is activated by dimerization, which occurs upon 2'-5'A binding, and results in cleavage of all RNA

Clematis hirsutissima. Originally isolated in 1792 by M. Heyer, It is the dimerization product of the toxin protoanemonin. One of the likely active agents in

biosynthetically from the aromatic amino acids phenylalanine and tyrosine, via dimerization and oxidative ring-cleavage of arylpyruvic acids, a process that also

of cells. Ligand binding to the extracellular domain induces dimerization. Dimerization of RTKs leads to autophosphorylation of tyrosine in the catalytic

ground state. Unprotected carbene analogs, including germylenes, has a dimerization nature. Free germylenes can be isolated under the stabilization of steric

ATPase domains of GyrB subunits. Binding of 2 ATP molecules leads to dimerization and, therefore, closing of the gates. Hydrolysis, on the contrary, opens

inactive monomers within the cell, their activation relies on dimerization. This dimerization occurs when initiator caspases are recruited to large protein

been shown to possess zinc finger domains. The protein contains a hAT dimerization domain nears its C-terminus. This domain is highly conserved in transposase

A domain The two ATP binding sites display cooperative behavior. The dimerization interface consists of two long helices, one from each monomer, that interact

overturned by compensation mechanisms. In the case of HER2, which acts as a dimerization partner of other EGFRs, constitutive activation leads to hyperproliferation

viral transcription activator protein Tat. Poly A plays roles both in dimerization and genome packaging since it is necessary for cleavage and polyadenylation

subdomain, and appears to undergo a unique conformational change upon dimerization, but its overall structure and mechanism of catalysis remain consistent

oligomerization and dimerization of conjugated dienes. For example, 1,5-cyclooctadiene and 4-vinylcyclohexene are produced by dimerization of 1,3-butadiene

telomerization schemes. For example carboalkoxylation has been coupled with the dimerization of 1,3-butadiene. This step produces a doubly unsaturated C9-ester: 2

work suggests that not a direct inactivation, but an alteration in TPI dimerization might underlie the pathology. This might explain why the disease is rare

to ring strain in the corresponding MCPs. When ring closure and TMM dimerization can be controlled, (3+2) cycloaddition affords isomeric mixtures of

contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds

genes. Acetylation of STAT3 has been suggested to be important for its dimerization, DNA-binding and gene-transcribing ability, and IL-6 JAK-STAT pathways

sunscreen and as an antimicrobial agent. It is derived from the oxidative dimerization of homogentisic acid. It has been both widely and falsely reported that

dimerization interaction. Experimentally, it has been seen that, in vivo, mutating the Dimerization initiation site (DIS) obstructed the dimerization

occurs through phosphorylation by an allosteric inhibitor, inhibiting dimerization and inducing a conformational change. Correct caspase-9 function is required

258 (17): 4271–4273. Uchino, M.; Chauvin, Y.; Lefebvre, G. (1967). "Dimerization of propylene by nickel complexes". Comptes Rendus de l'Académie des Sciences

HBX3− + (BH3) (X=F, Cl, Br, I) 2 BH3 → B2H6 The standard enthalpy of dimerization of BH3 is estimated to be −170 kJ mol−1. The boron atom in BH3 has 6

Comer JD, Vitalis EA, Mangili JA (Dec 1990). "Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein

sequences rich in guanine, such as GGGGC. They may also play a role in the dimerization of non-endogenous RNAs to facilitate the replication of some viruses

cycloadditions. One important process is the dimerization to give propiolactones. A specific example is the dimerization of the ketene of stearic acid to afford

five-membered rings. Thus, in order to prevent dimerization, a bulky moiety such as Mes* is often used. Dimerization frequently occurs in a head-to-tail manner

changes following selective phosphorylation, and its redox-sensitive dimerization. However, mounting evidence demonstrated that occludin is not only present

presence of acid catalysts. It can also be produced from isobutylene by dimerization using an Amberlyst catalyst to produce a mixture of iso-octenes. Hydrogenation

Alder and coworker, the structure was deduced in 1931. The spontaneous dimerization of neat cyclopentadiene at room temperature to form dicyclopentadiene

All GFCK structures that have been determined are dimeric, but their dimerization modes in different classes are different. The vascular endothelial growth

rendering the second dimer ineffective. Further studies have investigated dimerization of UGT enzyme polymorphisms and found both homodimer and heterodimer

octameric quaternary structure, two dimerization types can be seen that in turn, form the octamer structure. Dimerization is an important aspect of protein

{\displaystyle \mathrm {2X^{-}\rightleftharpoons X_{2}+2e^{-}} } (oxidative dimerization of the nucleophile) by the equation:   E n = E 0 + 2.60 {\displaystyle

The following is a partial list of the "G" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)

Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25):

monolignols. Thus, most lignans feature a C18 cores, resulting from the dimerization of C9 precursors. The coupling of the lignols occurs at C8. Eight classes

Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity chromatin binding protein binding

only aids in the formation of the tetrameric quaternary structure by dimerization but also serves as a substrate-binding site to facilitate RNA hydrolysis

proceeded via an endo-selective [4+2] cycloaddition with a Diels–Alder dimerization of 2H-pyran monomers 2a and 2b. Key observations that indicate a natural

Other amino acids involved in molecular functions such as catalysis, dimerization, etc. are also included. The database for the program also contains calculated

M010905200. PMID 11278782. Lee KK, Yonehara S (2002). "Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)"

from studies of the Ni-catalyzed linear- and cyclo-dimerization of ethylenes. Linear dimerization proceeds via beta-hydride elimination of the nickelacyclopentane

the mucous membrane that lines the nasal cavity. Furthermore, partial dimerization of the βk-2C-B will occur, since the nasal passages are slightly basic

protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine

domain upon binding to its recognition site. Cleavage only occurs upon dimerization, when the recognition domain is bound to its cognate site and in the

verified when viruses were exposed to UV light. UV radiation can cause dimerization of RNA, which prevents transcription by RNA polymerase. If the viral

amino acids long. Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves. The domain may

where they are more commonly called surface reconstructions or even dimerization. Surfaces so often support CDWs because they can be described by two-dimensional

bulky substituents on lead can sterically block this dimerization mode. Due to decreasing dimerization energy down Group 14, while monohalogenated stannylenes

all other type II restriction endonucleases. It also has an N-terminal dimerization subdomain formed by a short α-helix, a two-stranded antiparallel -sheet

cofactor and point mutations in the enzyme. A G473D mutation impairs dimerization and catalysis in human sulfite oxidase. Sulfur metabolism Bioinorganic

2". Cheng J, Yu L, Zhang D, Huang Q, Spencer D, Su B (2005-04-08). "Dimerization through the Catalytic Domain Is Essential for MEKK2 Activation". The

deletion of GSL3 leads to decreases in both viral RNA packaging and dimerization, mutagenic studies have shown that it does not eliminate encapsulation

activation of PKR. Binding to dsRNA is believed to activate PKR by inducing dimerization of the kinase domains and subsequent auto-phosphorylation reactions.

leucine zipper (bZIP) domain, which mediates the transcription factor's dimerization and DNA binding properties. The Maf extended homology region (EHR) is

in an equilibrium between homotetrameric and homodimeric forms. The dimerization interface is composed of symmetry-related loops that link identical monomers

Th1 cells, which express IFNγ, are generated by IL-27 through STAT1 dimerization and nuclear localization which subsequently leads to the expression of

operate as a two-headed motor and that motility can be regulated by motor dimerization, leading to the conclusion that KIF1A is monomeric in an inactive state

determination of dimerization of SorCS2 and the other two SorCS proteins with only few monomeric structures found. This dimerization is promoted by deglycosylation

Dimanganese decacarbonyl, which has the chemical formula Mn2(CO)10, is a binary bimetallic carbonyl complex centered around the first row transition metal

from a beta-propiolactone ring. A specific example is derived from the dimerization of the ketene of stearic acid. This ketene is generated by pyrolysis

three antiparallel alpha-helices over a twisted antiparallel beta-sheet. Dimerization of ClpS may occur through its N-terminal domain. This short extended

localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription

proposed to explain transmembrane receptors' mechanism of action. Dimerization: The dimerization model suggests that prior to ligand binding, receptors exist

allosteric ligand promoting dimerization of the identical subunits of the coenzyme pyridoxal phosphate. Such dimerization greatly decreases the Michaelis

licensing. In turn, the process of ORC dimerization is mediated by a cell cycle-dependent Noc3p dimerization cycle in vivo, and this role of Noc3p is

reduction of 1,2-dihalodisilane, by retro-Diels–Alder fragmentation, by dimerization of silylenes, by photofragmentation of cyclopolysilanes, or by rearrangement

the Dynamin protein superfamily. When ATP binds to this domain, EHD dimerization occurs, activating a cascade of reactions that results in the oligomerization

proposed to explain transmembrane receptors' mechanism of action. Dimerization: The dimerization model suggests that prior to ligand binding, receptors exist

to form isooctane. There are also other uses for dimerization. Gasoline produced through dimerization is highly unsaturated and very reactive. It tends

In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors. DP forms a heterodimer

THO with the nuclear cap-binding complex. As a chaperone, ALY promotes dimerization of transcription factors containing basic leucine zipper (bZIP) domains

(2017-01-18). "Mechanism of Single-Site Molecule-Like Catalytic Ethylene Dimerization in Ni-MFU-4l". Journal of the American Chemical Society. 139 (2): 757–762

disproportionation of formaldehyde (to methanol and formate) occurs. The initial dimerization of formaldehyde to give glycolaldehyde (1) occurs via an unknown mechanism

confers selectivity to zinc finger nucleases. Specificity is provided by dimerization, which decreases the probability of off-site cleavage. Each set of zinc

57. doi:10.3389/fnins.2014.00057. PMC 4018553. PMID 24834023. OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a

composed of a kinase domain, as well as leucine zipper and helix-loop-helix dimerization domains, and a carboxy-terminal NEMO-binding domain (NBD). Mutational

ways that RPTP catalytic activity can be regulated (for reviews, see ). Dimerization of identical RPTP proteins at the cell surface leaves the PTP domains

1063/1.2748049. PMID 17655439. Yi, Li; K. N. Houk (July 2001). "The Dimerization of Cyclobutadiene. An ab Initio CASSCF Theoretical Study". Journal of

follows: The dimerization reaction is unselective. By-products include acetaldehyde (due to isomerization). The selectivity and speed of dimerization can be

revealed plausible open and closed states, and also suggested role for dimerization in stabilizing segment 235-290 involved in interfacial interactions and

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent

extremely basic, the salt slowly reacts with acetonitrile, inducing dimerization to CH3C(NH2)=CHCN, which co-crystallizes. Tetramethyl­phosphonium fluoride

μ2-N-bridging mode arises when the free electron pair at nitrogen gives rise to dimerization. These dimeric complexes yield different M-N bond lengths depending on

Excitation to a carbene structure then accounts for the carbene-like dimerization that some persistent carbenes undergo over the course of days. Persistent

M, Ménard R (Nov 2003). "Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family". The Journal of Biological

Gene ontology Molecular function protein dimerization activity nucleotide binding microtubule motor activity protein binding microtubule binding ATP binding

5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity". J.

3-Hydroxybutyraldehyde (acetaldol), an aldol, formally the product of the dimerization of acetaldehyde 4-Hydroxybutyraldehyde, a chemical intermediate Hydroxybutanal

are involved in the alkene metathesis and in the oligomerization and dimerization of ethylene. In alkene metathesis, the Chauvin mechanism invokes the

"Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues"

elemental sulfur. The main route to cyclooctane derivatives involves the dimerization of butadiene, catalysed by nickel(0) complexes such as nickel bis(cyclooctadiene)

Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene. 10 (11): 2085–93. PMID 7784053. Zhang Y, Venkatraj

An example of an aryl organogallium(I) compound, note its reversible dimerization

monomeric nucleases often involve high levels of off-target effects, dimerization is an attractive strategy. In a dimer system, both nucleases must bind

ketones, derivatives functionalized with electrophiles, or products of dimerization. The mechanism of reduction itself depends on the nature of the reducing

Phosphorylation displaces the disordered R domain from positions preventing NBD dimerization and opening. The amino-terminus is part of the lasso motif which anchors

the receptor tyrosine kinase (RTK) pathway, which is initiated by the dimerization of two receptor tyrosine kinase monomers. When the dimer is formed, the

thought that NADP+ binding to the structural site was necessary for dimerization of the enzyme monomers. However, this was shown to be incorrect. On the

PDGF that can bind all three receptor combinations with high affinity. Dimerization is a prerequisite for the activation of the kinase. Kinase activation

begins when 2-bromocyclopentadienone undergoes a spontaneous Diels-Alder dimerization. One ketal of the endo isomer is subsequently selectively deprotected

function calcium ion binding G protein-coupled receptor activity protein dimerization activity transmembrane signaling receptor activity signal transducer

chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain

triphenylmethoxyl radical A, a rearrangement to diphenylphenoxymethyl C and its dimerization. It is unclear to this day whether in this rearrangement the cyclohexadienyl

ketones, derivatives functionalized with electrophiles, or products of dimerization. The mechanism of reduction itself depends on the nature of the reducing

for different protein-protein interactions and creates an additional dimerization interface. Unlike ORF7a, ORF8 lacks a transmembrane helix and is therefore

ortho-Carborane is the organoboron compound with the formula C2B10H12. The prefix ortho is derived from ortho. It is the most prominent carborane. This

PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization". The Journal of Biological Chemistry. 278 (48): 48099–48104. doi:10

Ciruela F, Rhodes A, McIlhinney RA (June 1999). "Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of

makes it an ideal heterobifunctional tool for use in chemically induced dimerization (CID). Additionally, TMP- HTag can be modified to include photo-cleavable

ontology Molecular function G protein-coupled receptor activity protein dimerization activity signal transducer activity neuropeptide receptor activity Cellular

C, Lucas-Meunier E, et al. (2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living

inhibit DNA binding of bHLH proteins. ID proteins also contain the HLH-dimerization domain but lack the basic DNA-binding domain and thus regulate bHLH transcription

function through non-covalent interactions. They may also assist in dimerization, and while they are found in a wide variety of enzymes, they are not

another, the leucines can interact as the teeth in a zipper, allowing dimerization of two proteins. When binding to the DNA, basic amino acid residues bind

similar reaction with phenylazotriphenylmethane in benzene. Again, the dimerization product of the persistent radical (phenylcyclohexydienyl) was absent

produced by hydroformylation of octenes. Isomeric octenes are produced by dimerization of butenes. These alcohol mixtures are used as solvents in paints and

suggesting the hydrophobic interaction is important for dimerization. Results show that the dimerization is essential to function. The active site is highly

Castellino FJ, Geiger JH. (June 2010) “Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg

forms a salt bridge with arginine and a hydrogen bond with glutamine. Dimerization is essential to maintaining function as the active site is found at this

carboxy-terminal tail over the kinase domain. Upon PDGF binding the dimerization of receptor releases the inhibitory conformations due to auto-phosphorylation

responsible for substrate binding C-terminal domain (CTD) which is the dimerization domain (base of the V). Between these domains, there are short charged

published a synthesis of symmetric macrocycles through a cross-metathesis dimerization of starting cycloolefins to afford C14, C18, and C20 dienes in 58-74%

PMID 23666085. S2CID 3025200. Jie, Chen (2014). "Phosphoregulation of the dimerization and functions of end-binding protein 1". Protein & Cell. 5 (10): 795–799

(December 1991). "Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis". The EMBO Journal

practice self-inhibition by dimerization. This is the only flavoprotein known to dimerize for inhibition and this dimerization is thought to be regulated

(A3243G) causes the native conformation to be destabilized, as well as dimerization in the tRNALeu(UUR). The uridine at the anticodon first position of the

is thought to participate in oligomerization, but not in the initial dimerization step. The presence of this region in a number of other complex-forming

receptor (EGFR) on the cell surface. This stimulates ligand-induced dimerization, activating the intrinsic protein-tyrosine kinase activity of the receptor

D-domain (Dimerization domain) is found in the upstream of the F-box domain, which is a conserved dimerization motif located in WD40 repeat F box proteins

extracellular virus. Tecovirimat acts as a molecular glue that promotes the dimerization of VP37. The drug prevents the virus from leaving an infected cell, hindering

Diao W, Dong C, Zhou H, Xie X, Wang Z, Shen Y, Long J (August 2015). "Dimerization of elongator protein 1 is essential for Elongator complex assembly".

reactions, excess of the alkene can be employed to avoid competitive dimerization of the enone. Reverse [2+2] photocycloaddition, decomposition of 1,2-dioxetanedione

distribution. This has been implicated in disorders such as epilepsy. CXCR4 dimerization is dynamic and increases with concentration. Drugs that block the CXCR4

Lillford PJ (1970). "A Kinetic and Equilibrium Study of Hydrogen Bond Dimerization of 2-Pyridone in Hydrogen Bonding Solvent". J. Am. Chem. Soc. 92 (26):

butadiene followed by oxidative dehydrogenation. The acid-catalyzed dimerization of styrene to give a 1,3-diphenylbutene, which then can be transformed

three-stranded antiparallel β-sheet flanked by three α-helices. The dimerization of LC-FACS is stabilized through a salt bridge between Asp15 of sequence

"F" subunit. The two subunits dimerize on the host cell surface. This dimerization is followed by oligomerization involving three additional leukocidin

(less than 10 kDa), and are involved in PSII assembly, stabilisation, dimerization, and photoprotection. Cytochrome b559, which forms part of the reaction

reactions, excess of the alkene can be employed to avoid competitive dimerization of the enone. Reverse [2+2] photocycloaddition, decomposition of 1,2-dioxetanedione

function calcium ion binding G protein-coupled receptor activity protein dimerization activity signal transducer activity transmembrane signaling receptor

Ross S, Wadhams GH, Smith E, Armitage JP, Watts A (2009). "Constitutive dimerization of the G-protein coupled receptor, neurotensin receptor 1, reconstituted

an N-terminal dimerization domain. Consisting of an intricate arrangement of α-helices, the rod domain, together with the dimerization-conducting N terminus

butadiene followed by oxidative dehydrogenation. The acid-catalyzed dimerization of styrene to give a 1,3-diphenylbutene, which then can be transformed

resulting from the dimerization of vitamin A. Gildeuretinol is a deuterated derivative of Vitamin A that is designed to reduce the dimerization of vitamin A

concentration of the chemokine. CCL5 may act as a monomer or a dimer. Dimerization is not necessary for binding to CCR5. Thus, CCL5 in nanomolar concentration

David A.; Aggarwal, Aneel K.; Schildkraut, Ira (1 September 1998). "FokI dimerization is required for DNA cleavage". Proceedings of the National Academy of

Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity transcription coactivator activity

glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition". Cell. 110 (1): 93–105. doi:10.1016/S0092-8674(02)00817-6

fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion". Developmental

or two other molecules of butadiene, i.e., dimerization and trimerization respectively. Via dimerization butadiene is converted to 4-vinylcyclohexene

N-methyltransferase CARM1 methylates and inhibits MDH1 by disrupting its dimerization, which represses malate–aspartate shuttle and inhibits mitochondria respiration

h-TRF1-AS. The protein structure contains a C-terminal Myb motif, a dimerization domain (TERF homology) near its N-terminus and an acidic N-terminus.

Taskén K (March 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in

usually an inactive monomer inhibited by ICAD. This is cleaved before dimerization. Apoptosis is a cell self-destruct process that removes toxic and/or

the Rubottom Oxidation with Bicyclic Silyl Enol Ethers; Synthesis and Dimerization Reactions of Bicyclic Α-Hydroxy Ketones (1994). "Stereochemistry of the

degradation pathways for these catalysts include hydrolysis and oxidation. Dimerization of the alkylidyne units remains possible, as can be seen from complex

}\longrightarrow 2\ [O_{2}F]^{\cdot }} } This radical subsequently undergoes dimerization, entering an equilibrium with tetraoxygen difluoride at temperatures

ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Mol. Endocrinol. 12 (9): 1432–40

published by Guy Salvesen suggests that the apoptosome may induce caspase-9 dimerization and subsequent autocatalysis. Activated caspase-9 stimulates the subsequent

phosphorylation also leads to the covalent dimerization of CSF1R via disulfide bonds. Covalent CSF1R dimerization is important for a series of modifications

employed to improve the cleavage specificity of FokI by modifying the dimerization interface so that only the intended heterodimeric species are active

Bennett, Steven H.; Aggarwal, Varinder K. (2022). "Organocatalytic Dimerization of Succinaldehyde". Organic Syntheses. 99: 139–158. doi:10.15227/orgsyn

interface between TLR4 and MD-2 is formed before binding LPS and the dimerization interface is induced by binding LPS. MD-2 has a β-cup fold structure

Gross, GG (December 2003). "Ellagitannin biosynthesis: Laccase-catalyzed dimerization of tellimagrandin II to cornusiin E in Tellima grandiflora". Phytochemistry

M011311200. PMID 11278883. Zhu CC, Cook LB, Hinkle PM (August 2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated

functional analyses suggest that abundant endogenous phospholipids, receptor dimerization, and the G-protein binding-induced conformational change of the cytoplasmic

the capability to form a protein dimer prior to secretion which causes dimerization to appear. The addition reaction of the same compound and molecules enhances

double bond rule, most alkyl thioketones are unstable with respect to dimerization. The energy difference between the p orbitals of sulfur and carbon is

al. reported the synthesis of the compound in a coupling reaction / dimerization with in-situ desilylation. A Heck variation was reported in 2013. Derivatives

Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor

from disabling A3G, including A3G agonists, ViF destabilizers and ViF dimerization antagonists. The company received seed funding from Trillium Group's

Norbornadiene dimerization

1021/ja00097a045. Webb, Simon P.; Gordon, Mark S. (July 1995). "The dimerization of TiH 4". Journal of the American Chemical Society. 117 (27): 7195–7201

different families, including those that molecularly disrupts the protein dimerization interface or reduces mRNA stability.[citation needed] Absence or insufficiency

Norbornadiene dimerization

With Tony Kosssiakoff and Bart DeVos, they discovered the activation/dimerization mechanism of human growth hormone, a paradigm for cytokine signaling

receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses". J. Biol. Chem. 267

Gene ontology Molecular function protein dimerization activity Cellular component nuclear membrane integral component of membrane nucleus nuclear envelope

catalysis involving alkyne complexes. Cuprous chloride also catalyzes the dimerization of acetylene to vinylacetylene, once used as a precursor to various polymers

ranunculin ↓ – glucose (maceration, enzymatically) protoanemonin ↓ dimerization (spontaneous) anemonin ↓ hydrolyzation 4,7-dioxo-2-decenedioic acid

thermal displacement reactions that afford α-olefin chains. Above 150 °C, dimerization of the α-olefins occurs. Aluminum hydroxide, the byproduct of the synthesis

57. doi:10.3389/fnins.2014.00057. PMC 4018553. PMID 24834023. OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a

PMID 11336703. Zhang Y, Neo SY, Han J, Lin SC (August 2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun

Bouvier M, Jockers R (Jun 2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living

Each subunit consists six β-strands, β A-F, and ten α-helices, α 1–10. Dimerization occurs along the faces of β C and α 3 of both monomers. BPGM is roughly

tinnitus. Tetrandrine is biosynthesized from a free radical coupled dimerization of S-N-methylcoclaurine: Synonyms include fanchinine, hanfangchin A,

PMC 449995. PMID 8605869. Lesage F, Reyes R, Fink M, et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge". EMBO J. 15 (23):

tyrosine phosphorylation. Villin-1 has the ability to dimerize and the dimerization site is located at the amino end of the protein. Villin-1 is an actin

Gene ontology Molecular function nucleotide binding protein dimerization activity GTP binding protein binding hydrolase activity protein kinase binding

to regenerate active catalyst is needed in this reaction. Reductive dimerization of electrophiles has long been known (Wurtz reaction, Ullman reaction

colorless liquid. Together with 2,3-dimethyl-2-butene it can be produced by dimerization of propylene. It is a precursor to the commercial fragrance tonalide

"Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding". The EMBO Journal. 20 (5): 1099–1113. doi:10

Gene ontology Molecular function proton channel activity protein dimerization activity sodium channel activity bicarbonate transmembrane transporter activity

PMID 8900182. Ye ZS, Baltimore D (Dec 1994). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12629–33

binding by a ligand, such as the epidermal growth factor or TGF alpha, dimerization occurs, leading to autophosphorylation on the intracellular tyrosine

betel oil. Chavicol is miscible with alcohol, ether, and chloroform. Dimerization of chavicol gives the neo-lignan magnolol. Chavicol is used as an odorant

biosynthesis. Sulfenyl iodides that are heavily sterically hindered from dimerization are stable. A related class of compounds are the alkylsulfur trichlorides

Paquette's 1982 synthesis of dodecahedrane. The first step involved reductive dimerization of the molecule to give dihydrofulvalene, not simple addition to give

Dimerization equilibrium observed for PS3−.

Dimerization of lactaldehyde leads to a mixture of stereoisomeric 1,4-dioxanes.

the product of this reaction was the expected anol, a highly reactive dimerization product in the mother liquors called dianol was also discovered by Charles

Although the cyclobutadiene derivative is stable (with respect to dimerization), it decomposes upon contact with O2. Samples of cyclobutadiene are unstable

Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain 1u5g: Crystal Structure of the PH Domain of

metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin". J. Biol. Chem

"Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions". Cell. 76 (5): 821–8

regulatory functions.[citation needed] Ligand binding causes two reactions: Dimerization of two monomeric receptor kinases or stabilization of a loose dimer.

and PCF2, where it has been shown to be involved in DNA-binding and dimerization. Finlayson SA (May 2007). "Arabidopsis Teosinte Branched1-like 1 regulates

CV dimer expression, while the wild type has been shown to boost the dimerization of complex V as well as enhance the ATP synthesis rate. Mutations in

57. doi:10.3389/fnins.2014.00057. PMC 4018553. PMID 24834023. OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a

signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor. In either case, the

Kadesch T (1991). "The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity". Genes Dev. 5 (6): 1057–66. doi:10.1101/gad.5.6.1057. PMID 2044953

the DeMayo reaction. Another example is shown below, the photochemical dimerization of cinnamic acid. The two trans alkenes react head-to-tail, and the isolated

"Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys. 399 (1):

produced by hydroformylation of octenes. Isomeric octenes are produced by dimerization of butenes. These alcohol mixtures are used as solvents in paints and

Gene ontology Molecular function protein dimerization activity heparanase activity beta-glucuronidase activity hydrolase activity, acting on glycosyl bonds

Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in

of replication in iterons: Transcriptional autorepression Initiator dimerization Initiator titration Handcuffing Transcriptional auto-repression is thought

doi:10.1074/jbc.273.3.1281. PMID 9430657. Leung IW, Lassam N (1999). "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated

Gene ontology Molecular function protein dimerization activity heparanase activity beta-glucuronidase activity hydrolase activity, acting on glycosyl bonds

chemotherapeutic agents. c-Myc, a transcription factor, can be inhibited during its dimerization with Max protein by molecules such as IIA6B17 and omomyc. Inhibition

step in the oligomeric process involves dimerization of the α-crystallin domain. In metazoans, dimerization by α-crystallin domains proceeds through

bacteria. VCC results of dimerization-impaired monomer and tethered dimer forms of HNP1 demonstrated the importance of dimerization. Replacing the conserved

commercially) focused on fatty alcohols, it has been investigated for the dimerization of ethanol to butanol. Organometallic catalysts have been investigated

similar physical properties. These compounds arise via the acid catalyzed dimerization of isobutene, a reaction that proceeds via the carbocation (CH3)3C+.

cases like the Immunoglobulin family proteins, conserved bulges help dimerization of the Ig domains. They are also of functional importance in the proteins

and IFNGR2, respectively. Binding of IFN-γ to IFNGR1 induces the rapid dimerization of IFNGR1 chains, thereby forming a site that is recognized by the extracellular

dimerization interface) and the virus-type replication-repair nuclease module (VRR_NUC, catalytic site) (Figure 1). DNA binding promotes dimerization

(December 1991). "A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable". The EMBO Journal

organomolybdenum and organotungsten compounds: additive-reductive carbonyl dimerization, spontaneous transformation of methyl ligands into μ-methylene ligands

isomerization of 2,3-dimethyl-1-butene. Another route involves direct dimerization of propylene. It can also be produced by photolysis of tetramethylcyclobutane-1

Bardelle C, Staddon JM (Nov 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. 322 (2): 170–8. doi:10.1016/j

factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription

distinct RNA-binding specificities with implications for RNA packaging and dimerization. J Biol Chem. 2018;293(42):16261‐16276. Antonucci JM, Kim SH, St Gelais

Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in

monomeric GTPases. Much of the SIMIBI class of GTPases is activated by dimerization. Named after the signal recognition particle (SRP), MinD, and BioD, the

indole alkaloids are known. They are produced in living organisms through dimerization of monomeric indole bases, in the following reactions: Mannich reaction

1126/science.283.5404.987. PMID 9974392. Ebie AZ, Fleming KG (February 2007). "Dimerization of the erythropoietin receptor transmembrane domain in micelles". Journal

action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization--a working hypothesis". Pharmacological Reports. 60 (5): 581–7. PMID 19066405

ligand recognition, TLR6 receptor dimerizes with TLR2. Ligand-mediated dimerization is crucial for recruiting the adaptor proteins, which are necessary for

tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization". The International Journal of Biochemistry & Cell Biology. 41 (11):

Cierpicki T, Paduch M, Derewenda ZS, Otlewski J (March 2006). "The dimerization mechanism of LIS1 and its implication for proteins containing the LisH

pancreatic cancer, CARM1 methylates and inhibits MDH1 by disrupting its dimerization, which represses mitochondria respiration and inhibits glutamine utilization

stable complexes with copper(II) salts. Furoxan Furoxan may be formed by dimerization of nitrile oxides Olofson, R. A.; Michelman, J. S. (1965). "Furazan"

Gene ontology Molecular function protein binding protein dimerization activity proton transmembrane transporter activity P-type proton-exporting transporter

center of cyclopentanone. Hydrolysis liberates the alkynyl alcohol. The dimerization of acetylene to vinylacetylene proceeds by insertion of acetylene into

Gene ontology Molecular function protein binding protein dimerization activity guanyl-nucleotide exchange factor activity Cellular component integral component

promote cross-coupling a diene to an olefin. Fe(acac)3 catalyzes the dimerization of isoprene to a mixture of 1,5-dimethyl-1,5-cyclooctadiene and 2,5-dimethyl-1

an unconventional myosin motor, which is functional as a dimer. The dimerization of myosin X is thought to be antiparallel. This behavior has not been

stable complexes with copper(II) salts. Furoxan Furoxan may be formed by dimerization of nitrile oxides Olofson, R. A.; Michelman, J. S. (1965). "Furazan"

Hydrohalogenation Hydrovinylation (including hydroarylation and olefin dimerization and others) Hydroacylation Hydroformylation (refers specifically to the

promote cross-coupling a diene to an olefin. Fe(acac)3 catalyzes the dimerization of isoprene to a mixture of 1,5-dimethyl-1,5-cyclooctadiene and 2,5-dimethyl-1

Cierpicki T, Paduch M, Derewenda ZS, Otlewski J (March 2006). "The dimerization mechanism of LIS1 and its implication for proteins containing the LisH

remaining, unpaired PSBD specifically interacts with one E3 homodimer. PSBD dimerization thus determines the subunit composition of the pyruvate dehydrogenase

1997). "Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro". The Journal of Biological Chemistry. 272 (45):

tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization". The International Journal of Biochemistry & Cell Biology. 41 (11):

produced by separation from crude C4 refinery streams and by ethylene dimerization. The former affords a mixture of 1-and 2-butenes, while the latter affords

achieves tetrahedral coordination geometry. Some [Fe4S4] clusters arise via dimerization of square-shaped [Fe2S2] precursors. Many synthetic analogues are known

protein from Forsythia intermedia, production of (+)-pinoresinol is greatly enriched while production of other products of dimerization is inhibited.

necessary for its clustering at cell–cell contact sites but not for its cis dimerization or trans interaction". J. Biol. Chem. 275 (1): 613–8. doi:10.1074/jbc

are replaced with C–F bonds. Octafluorocyclobutane is produced by the dimerization of tetrafluoroethylene and the reductive coupling of 1,2-dichloro-1,1

crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring"

integral to the complex’s function, most likely due to their importance to dimerization. Substituting these residues has no predicted impact on secondary structure

F3C–CH=SF4 or F3C–CH2–SF5, is an unstable gas that readily undergoes dimerization to form trans-(CF3)(SF3)C=C(CF3)(SF3) at above –50 °C. Mayr, A.; Bastos

autophosphorylation induced by a mechanism of FGF-mediated receptor dimerization. Receptor activation gives rise to a signal transduction cascade that

interactions. Procaspase-8 activation is thought to occur through a dimerization process with other procaspase-8 molecules, known as an induced proximity

Bennett, Steven H.; Aggarwal, Varinder K. (2022). "Organocatalytic Dimerization of Succinaldehyde". Organic Syntheses. 99: 139–158. doi:10.15227/orgsyn

1074/jbc.M103674200. PMID 11555640. Ma K, Vattem KM, Wek RC (May 2002). "Dimerization and release of molecular chaperone inhibition facilitate activation of

have different isoforms, and some combination of isoforms result in dimerization while other combinations do not. For example, beta1 binds both gamma

still recommended in some cases: Cuprous chloride also catalyzes the dimerization of acetylene to vinylacetylene, once used as a precursor to various polymers

readily rearranges by migration of H from P to carbon-2, followed by dimerization. Most phospholes are tertiary, typically P-methyl or P-phenyl. The nonaromaticity

Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A (Sep 2001). "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually

uncharged/deacylated tRNA which causes a conformational change, resulting in dimerization. Dimerization then causes autophosphorylation and activation. Other stressors

location of the active site and dimerization interface that is highly similar to thiolase-fold containing enzymes. The dimerization interface contains both hydrophobic

Stöcklein W, Fürst DO (2003). "The limits of promiscuity: isoform-specific dimerization of filamins". Biochemistry. 42 (2): 430–9. doi:10.1021/bi026501+. PMID 12525170

acidic workup. The Kolbe electrolysis is an electrolytic, decarboxylative dimerization reaction. It gets rid of the carboxyl groups of two acid molecules, and

not yet been elucidated. However, it has been hypothesized that the dimerization of the two naphthoquinone units yields rubicordifolin. Naphthoquinones

Regarding the piggyBac transposase, his laboratory has shown that the dimerization through the Ring Finger Domain present at the C-terminus attenuates the

Molecular function protein binding protein homodimerization activity protein dimerization activity guanyl-nucleotide exchange factor activity Cellular component

melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking". Journal of Biological Chemistry. 284 (34): 22641–22648

holo-complex. MukBEF and JetABC form higher-order assemblies through dimerization mediated by their kleisin subunits, a configuration often referred to

prolonged usage. Reactions within catalytic distillation columns include: dimerization - forming a single molecule from two monomers with weak or strong bonds

and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner". Molecular and Cellular Biology. 18 (9): 5042–5051. doi:10.1128/mcb

ISSN 0368-1769. de SOUSA, J. B.; HO, S. K. (1960). "Disproportionation and Dimerization of the Benzyloxyl Free Radical in Solution". Nature. 186 (4727): 776–778

leukotriene or purine receptors in mediating cell responses and this dimerization may explain some of the discrepancies reported for the ability of these

soluble in most organic solvents. It is prepared by the base-catalysed dimerization of diketene. Commonly used organic bases include imidazole, DABCO, and

filamin binding bile acid transmembrane transporter activity protein dimerization activity actin binding calmodulin binding molecular function identical

(1994-08-10). "Ellagitannins in woods of sessile oak and sweet chestnut dimerization and hydrolysis during wood ageing". Phytochemistry. 36 (5): 1253–1260

crystal structure of the intrinsic dimerization sh3 domain of the ib1 scaffold protein 2fpe: Conserved dimerization of the ib1 src-homology 3 domain 2fpf:

the TIM barrel fold, which consists of eight parallel beta strands). Dimerization was observed in which a helix from each subunit interacts with the other

holo-complex. MukBEF and JetABC form higher-order assemblies through dimerization mediated by their kleisin subunits, a configuration often referred to

± 1.5 kcal/mole at 298 K Entropy: 24.2±0.1 cal/mole.deg Enthalpy of Dimerization for the reaction Sn2Te2->2SnTe(g) :46.9 ± 6.0 kcal/mole Generally Pb

and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner". Molecular and Cellular Biology. 18 (9): 5042–5051. doi:10.1128/mcb

Bouvier M, Jockers R (Jun 2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living

AS, Shamota TV, Schreiner PR, Fokin AA (2011). "Selective reductive dimerization of homocubane series oximes". Russian Journal of Organic Chemistry. 47

David A.; Aggarwal, Aneel K.; Schildkraut, Ira (September 1998). "Fok I dimerization is required for DNA cleavage". Proceedings of the National Academy of

"One-Pot Synthesis Benzils from Aldehydes Via Nhc-Catalyzed Benzoin Dimerization Under Metal-Free Conditions in Water". Journal of the Chilean Chemical

trans-3,4-diethyl-1,2-dithietane 1,1-dioxide, formed by the spontaneous dimerization of the lachrymatory agent syn-propanethial-S-oxide, found in onion. In

ClCF2−CFCl(I) The latter is a precursor to hexafluorobutadiene. Thermal dimerization of chlorotrifluoroethylene gives 1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane

skeletal muscle alpha-actinin cDNA into nonmuscle and myogenic cells: dimerization is not essential for alpha-actinin to bind to microfilaments". Exp. Cell

Chelating bis(allyl) complexes are intermediates in the metal-catalyzed dimerization of butadiene to give vinylcyclohexene and cycloocta-1,5-diene. Complexes

helix-turn-helix motif in transmembrane domain 3 provides the driving force of dimerization. Holins regulate the length of the infection cycle of tailed phages (caudovirales)

protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations

disulfide bonds form between cysteines 48 and 139 on opposite chains. This dimerization has no effect on the catalytic activity of the enzyme. PNMT catalyzes

Molecular function calcium activated cation channel activity protein dimerization activity protein binding voltage-gated chloride channel activity chloride

also a dimer with a Leu389 residue located between the dimers and this dimerization is seen to be essential for its kinase activity and protein stability

binds to the SARAH domain of MST2 and prevents RASSF1A-mediated MST2 dimerization and subsequent downstream pro-apoptotic signaling. Research has shown

"Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch. Biochem. Biophys. 399 (1):

(k at 298 K = 8×106 M s): 2 HNO → N2O + H2O The reaction proceeds via dimerization to hyponitrous acid, H2N2O2, which subsequently undergoes dehydration

finger, two zinc binding domains, termed the B1 and B2 boxes, and an RBCC dimerization domain composed of two alpha helical coiled coil domains. The PML gene

Zhang, Jian; Engelman, Donald M. (1992). "Sequence specificity in the dimerization of transmembrane .alpha.-helixes". Biochemistry. 31 (51): 12719–12725

exposure to the thrombospondin ligand causes CD36 to dimerize. This dimerization has been proposed to play an important role in CD36 signal transduction

Examples of di-vinyl-substituted diphosphenes arise via a ring opening/dimerization process from kinetically unstable 2H-phosphirenes. However, the conjugation

acetaldehyde. With HCl, it gives RhCl2(C2H2)2−. Rh2Cl2(C2H4)4 catalyzes the dimerization of ethylene to 1-butene. Carbonylation affords rhodium carbonyl chloride

Membrane Dipeptidase. Cys 361 Alone Is Involved in Disulfide-Linked Dimerization†." Biochemistry 35.38 (1996): 12511-2517. Web. Nitanai, Yasushi, Yoshinori

donating aldehyde with a proton accepting aldehyde to avoid undesired homo-dimerization. The reaction can be extended to aliphatic aldehydes with base catalysis

for its nuclear localization, centromere/kinetochore targeting, and dimerization". J. Biol. Chem. 270 (33): 19545–50. doi:10.1074/jbc.270.33.19545. PMID 7642639

John C. Stowell (1971). "tert-Alkylnitroso compounds. Synthesis and dimerization equilibriums". J. Org. Chem. 36 (20): 3055–3056. doi:10.1021/jo00819a038

and 84° from Fcis, and the torsion compared to Ftop is about 95°. The dimerization reaction 2SF2 ⇌ FSSF3 is reversible. It also disproportionates: SF2 +

acetaldehyde. With HCl, it gives RhCl2(C2H2)2−. Rh2Cl2(C2H4)4 catalyzes the dimerization of ethylene to 1-butene. Carbonylation affords rhodium carbonyl chloride

demonstrated for part of the sequence believed to have a role in mediating dimerization and oligomerization of the protein. The BK, JC, and SV40 agnoproteins

the formation of hydrogen fluoride and sulfuric acid. In water, the dimerization reaction of hydroxyl radicals can form hydrogen peroxide, while in saline

Examples of di-vinyl-substituted diphosphenes arise via a ring opening/dimerization process from kinetically unstable 2H-phosphirenes. However, the conjugation

of Lithium Superoxide LiO2 in the Gas Phase: Computational Study of Dimerization and Disproportionation Reactions". The Journal of Physical Chemistry

sensitivity by synthesizing cGMP. Low concentrations of calcium cause the dimerization of RETGC-1 proteins through stimulation from guanylate cyclase-activating

Src homology 2 (SH2) domain, a pleckstrin homology (PH) domain, and a dimerization domain. The SH2 domain spans approximately 100 amino acid residues and

receiver domain (D1). Phosphorylation of the receiver domain increases the dimerization affinity by approximately 10-fold over non-phosphorylated domains. Inhibition

PMID 10424431. Fan QR, Long EO, Wiley DC (August 2000). "Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor". The Journal of

nonplanar and can be oxidized to their radical cations. Photolysis leads to dimerization via a [2+2] cycloaddition. Thianthrene is dibenzo-1,4-dithiin. 1,2-Dithiins

Dimerization in Ferrimagnetic Chains and Square Lattices", J. Phys. Condensed Matter 12, 9949 (2000). Aiman Al-Omari and A.H. Nayyar, "Dimerization of

rhodium catalyst. With the six-membered alkyl metal enolate intermediate, dimerization or reaction with an added alpha-beta unsaturated ketone yields a 1,3-substituted

5'-phosphosulfate synthase 2 PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) PCDH15: protocadherin

same strand of DNA become covalently linked. The bond length of this dimerization is shorter than the bond length of normal B-DNA structure which produces

the Nazarov cyclization reaction and in the Rauhut–Currier reaction (dimerization). α,β-Unsaturated thioesters are intermediates in several enzymatic processes

whose 3D structure is known, has unique NMR spectra and is stabilized by dimerization and 28 Cα-H··O=C hydrogen bonds. The PPII helix is not common in transmembrane

ATC domains do so into trimers. The hexamers are then formed by DHO dimerization of two ATC trimers, and this connection does not impact the kinetic properties

(cystine knot) domain at the protein’s C-terminal end: Involved in VWF dimerization. VWF is one of the few proteins carrying ABO blood group antigens. After

and microtubule binding, a central coiled-coil region that mediates dimerization and interaction with partner proteins, and a C-terminal tail domain,

integrins (LFA-1, integrin alphaXbeta2/CR4/p150,95, and Mac-1/CR3) by dimerization with different CD11 subunits. Mutations in the ITGB2 gene lead to absent

This includes and NADPH-binding Domain, FAD-binding domain(s) and a dimerization domain. Each monomer contains 478 residues and one FAD molecule. GR is

Fernandez; Delcroix, D. (2020). "Nickel Catalyzed Olefin Oligomerization and Dimerization". Chemical Reviews. 120 (15): 7919–7983. doi:10.1021/acs.chemrev.0c00076

tumor-bearing host. Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for lymphocyte recruitment

tendency to form dimers in solution, especially in the presence of oxygen. Dimerization greatly lowers the efficiency of subsequent coupling reactions such as

mixture of cis and trans 2-butene: 2 CH2=CH2 → CH3−CH2−CH=CH2 Ethylene dimerization was shown to involve catalysis by the aforementioned ethylene complexes

Gene ontology Molecular function protein dimerization activity SNAP receptor activity calcium-dependent protein binding protein binding SNARE binding Cellular

map out which regions of the protein are necessary for its stability, dimerization, and binding capacity. A study used a technique called in vivo complementation

Bardelle C, Staddon JM (Nov 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Analytical Biochemistry. 322 (2): 170–8. doi:10

aminoacyl-tRNA ligase activity nucleotide binding ligase activity protein dimerization activity ATP binding bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

Dimerization of a carboxylic acid by formation of hydrogen bonds (shown as dotted lines)

Geith, J.; Klapötke, T. M.; Krumm B. (2002). "Synthesis, Properties and Dimerization Study of Isocyanic Acid" (PDF). Z. Naturforsch. 57b (1): 19–25. doi:10

is the beta sheet, leading researchers to hypothesize the presence of dimerization domains within ICAM-1. The protein encoded by this gene is a type of

Héroult M, Lemaître G, et al. (2000). "Glycosaminoglycans promote HARP/PTN dimerization". Biochem. Biophys. Res. Commun. 266 (2): 437–42. doi:10.1006/bbrc.1999

unfolded protein response has a luminal N-terminal ligand-independent dimerization domain". The Journal of Biological Chemistry. 277 (21): 18346–18356.

S2CID 253063290. "Retraction for Lee et al., Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization". Proceedings of the National Academy

characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking". The Journal of Investigative Dermatology

depolarization. Ca2+-binding to the C2B domain confers synaptotagmin dimerization involved in the fusion step of synaptic vesicles by Ca2+-dependent self-clustering

Jin-Hu; Zhu, Rong (2022). "Synthesis of Polydiynes via an Unexpected Dimerization/Polymerization Sequence of C3 Propargylic Electrophiles". Journal of