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searching for DNA-binding domain 301 found (446 total)

WRKY protein domain (1,126 words) [view diff] exact match in snippet view article find links to article

significant area of plant research for the past 20 years. The WRKY DNA-binding domain recognizes the W-box (T)TGAC(C/T) (and variants of this sequence)

Zinc finger (4,882 words) [view diff] exact match in snippet view article find links to article

as tandem repeats with two, three, or more fingers comprising the DNA-binding domain of the protein. These tandem arrays can bind in the major groove of

TCF/LEF family (2,039 words) [view diff] exact match in snippet view article find links to article

However, since the protein structure of beta-catenin did not reveal any DNA-binding domain, it was still unclear how nuclear beta-catenin could regulate Wnt

TBX19 (285 words) [view diff] exact match in snippet view article find links to article

a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the

HOXD1 (626 words) [view diff] exact match in snippet view article find links to article

of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription

Basic helix–loop–helix (1,402 words) [view diff] exact match in snippet view article find links to article

Basic helix–loop–helix DNA-binding domain Basic helix–loop–helix structural motif of ARNT. Two α-helices (blue) are connected by a short loop (red). Identifiers

RFX2 (699 words) [view diff] no match in snippet view article find links to article

transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory

T-box (1,078 words) [view diff] exact match in snippet view article find links to article

and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is

RFX3 (613 words) [view diff] no match in snippet view article find links to article

transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory

RFX4 (667 words) [view diff] no match in snippet view article find links to article

transcription factors that contain a highly conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory

Integrase (1,288 words) [view diff] exact match in snippet view article find links to article

Zn(II) cation), a catalytic core domain (RNaseH fold), a C-terminal DNA-binding domain (SH3 fold). Crystal and NMR structures of the individual domains and

POU2F1 (1,924 words) [view diff] no match in snippet view article find links to article

"Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with

Eomesodermin (1,817 words) [view diff] exact match in snippet view article find links to article

encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors, which control

Leafy (678 words) [view diff] no match in snippet view article find links to article

flowers earlier. The LEAFY protein has two conserved domains: the DNA binding domain, a helix-turn-helix motif buried inside a unique 7-helix fold and

Rfx family member 8, lacking rfx dna binding domain (83 words) [view diff] no match in snippet view article find links to article

RFX family member 8, lacking RFX DNA binding domain is a protein that in humans is encoded by the RFX8 gene. GRCh38: Ensembl release 89: ENSG00000196460

TBX22 (1,333 words) [view diff] exact match in snippet view article find links to article

phylogenetically conserved family of proteins that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the

GCM transcription factors (535 words) [view diff] exact match in snippet view article find links to article

domain as a new class of Zn-containing DNA-binding domain with no similarity to any other DNA-binding domain. The GCM domain consists of a large and

Replication protein A1 (1,549 words) [view diff] exact match in snippet view article find links to article

subunit of human replication protein A contains a single-stranded DNA-binding domain". J. Biol. Chem. 273 (7): 3932–6. doi:10.1074/jbc.273.7.3932. PMID 9461578

Heat shock factor protein 1 (2,454 words) [view diff] no match in snippet view article find links to article

Heat shock factor protein 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. HSF1 is highly conserved in eukaryotes and is the primary

JARID2 (1,141 words) [view diff] no match in snippet view article find links to article

embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID). In vitro studies of

Retinoic acid receptor beta (1,275 words) [view diff] exact match in snippet view article find links to article

heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure

Inhibitor of DNA-binding protein (1,201 words) [view diff] exact match in snippet view article find links to article

proteins also contain the HLH-dimerization domain but lack the basic DNA-binding domain and thus regulate bHLH transcription factors when they heterodimerize

DMP1 (1,076 words) [view diff] no match in snippet view article find links to article

phosphorylation sites, a functional Arg-Gly-Asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein

C-Repeat Binding Factor (98 words) [view diff] no match in snippet view article find links to article

Response Element Binding factors (DREBs), they are a subfamily of AP2 DNA binding domain transcription factors. Stockinger, E. J., Gilmour, S. J. & Thomashow

MAEB RNA motif (457 words) [view diff] exact match in snippet view article find links to article

MAEB were considered. One is that the MAEB stem-loop is really a DNA-binding domain of a dimeric protein, and that the two subunits of this protein bind

Adenosine deaminase z-alpha domain (267 words) [view diff] no match in snippet view article find links to article

deaminase (ADAR), an RNA-editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured

Retinoid X receptor alpha (2,892 words) [view diff] exact match in snippet view article find links to article

assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix". Eur. J. Biochem. 224 (2):

EGR2 (2,066 words) [view diff] exact match in snippet view article find links to article

mice, the protein coding ability of the Krox20 gene (including the DNA-binding domain of the zinc finger) is diminished. These mice are unable to survive

Retinoid X receptor gamma (1,087 words) [view diff] case mismatch in snippet view article find links to article

HOMODIMERIC ASSEMBLY OF THE RXR ON DNA 1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1

TBX2 (2,740 words) [view diff] exact match in snippet view article find links to article

a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors

FOXO4 (2,764 words) [view diff] exact match in snippet view article find links to article

leukemia. The fusion proteins formed by these translocations lack the DNA-binding domain, causing the protein to lose function. In gastric cancers (GC), it

TBX5 (gene) (2,467 words) [view diff] exact match in snippet view article

a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the

DNAJC1 (492 words) [view diff] exact match in snippet view article find links to article

Solution Structure of RSGI RUH-037, a myb DNA-binding domain in human cDNA 2cqr: Solution structure of RSGI RUH-043, a myb DNA-binding domain in human cDNA

TEAD1 (4,085 words) [view diff] no match in snippet view article find links to article

the TEAD family share a highly conserved DNA binding domain called the TEA domain. This DNA binding domain has a consensus DNA sequence 5’-CATTCCA/T-3’

Sp3 transcription factor (517 words) [view diff] exact match in snippet view article find links to article

regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function

Vitamin D receptor (2,646 words) [view diff] exact match in snippet view article find links to article

resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures". Clin. Endocrinol. 41 (5): 581–90. doi:10.1111/j

3H domain (269 words) [view diff] exact match in snippet view article find links to article

de novo NAD synthesis pathway regulators. TM1602 has an N-terminal DNA-binding domain and a C-terminal 3H regulatory domain. The N-terminal domain appears

Retinoid X receptor beta (1,150 words) [view diff] case mismatch in snippet view article find links to article

HOMODIMERIC ASSEMBLY OF THE RXR ON DNA 1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1

PARP4 (990 words) [view diff] no match in snippet view article find links to article

to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl)

PKNOX2 (564 words) [view diff] no match in snippet view article find links to article

sequence-specific transcription factors that share a highly conserved DNA binding domain and play a crucial role in cell proliferation, differentiation and

OLIG2 (3,206 words) [view diff] exact match in snippet view article find links to article

in length, 32 kDa in size and contains one basic helix-loop-helix DNA-binding domain. It is one of the three members of the bHLH family. The other two

FLI1 (2,018 words) [view diff] exact match in snippet view article find links to article

Melot T, Peter M, et al. (September 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359

POLR2I (970 words) [view diff] no match in snippet view article find links to article

subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed

GCM1 (840 words) [view diff] exact match in snippet view article find links to article

sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. In cancer

TCF7L1 (892 words) [view diff] no match in snippet view article find links to article

signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular

Mineralocorticoid receptor (1,632 words) [view diff] case mismatch in snippet view article find links to article

THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN 1rgd: STRUCTURE REFINEMENT OF THE GLUCOCORTICOID RECEPTOR-DNA BINDING DOMAIN FROM NMR DATA BY RELAXATION

Transcription factor Sp1 (3,441 words) [view diff] no match in snippet view article find links to article

encoding transcription factor Sp1 and functional analysis of the DNA binding domain". Cell. 51 (6): 1079–90. doi:10.1016/0092-8674(87)90594-0. PMID 3319186

TEAD2 (2,030 words) [view diff] exact match in snippet view article find links to article

transcriptional enhancer factor (TEF) family), which contain the TEA/ATTS DNA-binding domain. Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4.

ZRF1 (586 words) [view diff] exact match in snippet view article find links to article

family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is

Jun dimerization protein (4,166 words) [view diff] exact match in snippet view article find links to article

(INHAT) region is from position 35 to 135, which is located before the DNA-binding domain. JDP2 is expressed ubiquitously but is detected mainly in the cerebellum

ZNF366 (880 words) [view diff] exact match in snippet view article find links to article

human monocyte-derived dendritic cells (mo-DCs). DC-SCRIPT contains a DNA-binding domain (11 C2H2 zinc (Zn) fingers), flanked by a proline-rich and an acidic

BPTF (1,104 words) [view diff] exact match in snippet view article find links to article

reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation

Gene knockdown (1,611 words) [view diff] no match in snippet view article find links to article

have two important functional components: a DNA binding domain and a DNA cleaving domain. The DNA binding domain is a sequence-specific transcription activator-like

Apetala 2 (953 words) [view diff] no match in snippet view article find links to article

called ANT, which is composed of two AP2 domains homologous with the DNA binding domain of ethylene response element binding proteins. Another study by Maes

TEAD4 (1,017 words) [view diff] exact match in snippet view article find links to article

(TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4.

GATA zinc finger (488 words) [view diff] exact match in snippet view article find links to article

sequence, to the N-terminal zinc module of the glucocorticoid receptor DNA-binding domain. The helix and the loop connecting the 2 beta-sheets interact with

CGGBP1 (877 words) [view diff] exact match in snippet view article find links to article

167 amino acids and a mass of 20kDa and includes a C2H2 zinc finger DNA-binding domain. The human gene is on chromosome 3 at 3p11.1, right next to the centromere

Steroid hormone receptor (2,749 words) [view diff] no match in snippet view article find links to article

domain between the different receptors. DNA binding domain: This centrally located highly conserved DNA binding domain (DBD) consists of two non-repetitive

Homeotic selector gene (1,409 words) [view diff] exact match in snippet view article find links to article

regulation. Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. Changes in the expression and function of

GTF2F2 (1,054 words) [view diff] case mismatch in snippet view article find links to article

1bby: DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, MINIMIZED AVERAGE 1f3u: CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF 2bby: DNA-BINDING

Fatty acid metabolism regulator protein FadR (355 words) [view diff] exact match in snippet view article find links to article

member of the GntR family of bacterial transcription regulators. The DNA-binding domain is well conserved for this family, whereas the C-terminal effector-binding

KilA-N domain (293 words) [view diff] exact match in snippet view article find links to article

In molecular biology, the KilA-N domain is a conserved DNA-binding domain found at the N-terminus of the poxvirus D6R/NIR proteins. It is also found in

GTF2F2 (1,054 words) [view diff] case mismatch in snippet view article find links to article

1bby: DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, MINIMIZED AVERAGE 1f3u: CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF 2bby: DNA-BINDING

GATA transcription factor (995 words) [view diff] no match in snippet view article find links to article

non-vertebrates, GATA transcription factors contain one zinc finger DNA binding domain (ZNI). In humans, GATA transcription factors contain two zinc finger

FOXK1 (519 words) [view diff] case mismatch in snippet view article find links to article

structure and Dynamics of DNA-Binding Domain of Myocyte Nuclear Factor 2d2w: Solution structure and Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor

Telomeric repeat-binding factor 1 (2,474 words) [view diff] exact match in snippet view article find links to article

Yoshimura S, Aimoto S, Nishimura Y (1998). "Solution structure of the DNA-binding domain of human telomeric protein, hTRF1". Structure. 6 (8): 1057–65. doi:10

PAX3 (4,308 words) [view diff] no match in snippet view article find links to article

Q− isoform. PAX3 encodes a transcription factor with an N-terminal DNA binding domain consisting of a paired box (PD) encoded by exons 2, 3, and 4, and

IRF2 (1,192 words) [view diff] no match in snippet view article find links to article

REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE 1irg: INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES 2irf:

SOX6 (1,178 words) [view diff] exact match in snippet view article find links to article

transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind

MYBL2 (1,486 words) [view diff] exact match in snippet view article find links to article

CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES 2d9a: Solution Structure of RSGI RUH-050, a myb DNA-binding domain in mouse cDNA

RFX1 (1,448 words) [view diff] no match in snippet view article find links to article

domains including a highly conserved, centrally located, winged helix DNA binding domain as well as a dimerization domain located in the C-terminal region

H2TH domain (709 words) [view diff] exact match in snippet view article find links to article

molecular biology, the H2TH domain (helix-2turn-helix domain) is a DNA-binding domain found in DNA glycosylase/AP lyase enzymes, which are involved in base

Van der Woude syndrome (1,579 words) [view diff] no match in snippet view article find links to article

nine transcription factors with a highly conserved helix-turn-helix DNA binding domain called the Smad-interferon regulatory factor binding domain (SMIR)

Z-DNA (4,310 words) [view diff] no match in snippet view article find links to article

Z-RNA and the B–Z junction. Biological studies suggested that the Z-DNA binding domain of ADAR1 may localize this enzyme that modifies the sequence of the

Steroidogenic factor 1 (3,478 words) [view diff] exact match in snippet view article find links to article

for transcriptional interactions. A 30-amino acid extension of the DNA-binding domain known as the A-box stabilizes monomeric binding by acting as a DNA

Retinoic acid receptor alpha (2,847 words) [view diff] no match in snippet view article find links to article

Moore DD (May 1996). "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors". Science. 272 (5266): 1336–9

THAP1 (680 words) [view diff] exact match in snippet view article find links to article

protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4

ARID5B (641 words) [view diff] exact match in snippet view article find links to article

Whitson R, Itakura K, Chen Y (Aug 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry. 40 (31): 9142–50. doi:10

GntR-like bacterial transcription factors (369 words) [view diff] exact match in snippet view article find links to article

effector-binding or oligomerisation domain at the C-terminus. The DNA-binding domain is well conserved in structure for the whole of the GntR family, consisting

Sleeping Beauty transposon system (2,762 words) [view diff] exact match in snippet view article find links to article

various combinations of changes. Further work has shown that the DNA-binding domain consists of two paired sequences, which are homologous to sequence

Retinoic acid receptor gamma (1,208 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 1exa: ENANTIOMER

Iron dependent repressor (696 words) [view diff] no match in snippet view article find links to article

of iron-regulated and manganese-regulated repressors show that the DNA binding domain contains three alpha-helices and a pair of antiparallel beta-strands

HMGN1 (1,019 words) [view diff] exact match in snippet view article find links to article

relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved

CDC5L (1,355 words) [view diff] exact match in snippet view article find links to article

structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein 2din: Solution structure of the Myb_DNA-binding domain of human Cell division

ZFN (70 words) [view diff] exact match in snippet view article find links to article

finger nuclease, a nuclease enzyme coupled to a zinc finger-based DNA-binding domain The Zero-Configuration File Network, an open-source network program

Liver receptor homolog-1 (1,418 words) [view diff] case mismatch in snippet view article find links to article

DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter 2ff0: Solution Structure of Steroidogenic Factor 1 DNA Binding Domain

INSM1 (630 words) [view diff] exact match in snippet view article find links to article

is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker

FOXJ1 (1,996 words) [view diff] no match in snippet view article find links to article

2, band 5, sub-band 1. FOXJ1 has a conserved 100 amino acid long DNA binding domain. This gene encodes a member of the forkhead family of transcription

SoxC group (591 words) [view diff] no match in snippet view article find links to article

The SoxC proteins have 2 domains, the first an Sry-related HMG box DNA binding domain that is located near the N-terminal and the second a trans-activation

JPH2 (932 words) [view diff] no match in snippet view article find links to article

contains an evolutionarily conserved nuclear localization signal and a DNA binding domain. During (heart) disease, stress-activated calpain converts the full

Replication protein A3 (920 words) [view diff] exact match in snippet view article find links to article

subunit of human replication protein A contains a single-stranded DNA-binding domain". The Journal of Biological Chemistry. 273 (7): 3932–6. doi:10.1074/jbc

Aureochromes (758 words) [view diff] no match in snippet view article find links to article

photoreceptors is unique in a way because of the presence of a bZIP (DNA binding domain) along with LOV (light perception) domain which makes it function

Two-hybrid screening (6,112 words) [view diff] exact match in snippet view article find links to article

transcription factor is split into two separate fragments, called the DNA-binding domain (DBD or often also abbreviated as BD) and activating domain (AD).

MAFG (2,631 words) [view diff] exact match in snippet view article find links to article

Morohashi A, Yamamoto M, Tanaka T (Apr 2002). "Solution structure of the DNA-binding domain of MafG". Nature Structural Biology. 9 (4): 252–6. doi:10.1038/nsb771

KIAA1826 (371 words) [view diff] no match in snippet view article find links to article

MSANTD4 Identifiers Aliases MSANTD4, KIAA1826, Myb/SANT DNA binding domain containing 4 with coiled-coils External IDs MGI: 1925350; HomoloGene: 34935;

Aled Edwards (2,130 words) [view diff] exact match in snippet view article find links to article

Edwards, A. M.; Frappier, L. (1995-10-06). "Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1". Cell. 83

Replication protein A2 (1,479 words) [view diff] exact match in snippet view article find links to article

subunit of human replication protein A contains a single-stranded DNA-binding domain". The Journal of Biological Chemistry. 273 (7): 3932–6. doi:10.1074/jbc

Small nucleolar RNA SNORA73 (712 words) [view diff] case mismatch in snippet view article find links to article

its ADPRylation (PAR) function. SNORA73 Interacts with the PARP1 DNA-Binding Domain. In addition, the snoRNA-activated PARP1 ADPRylates DDX21 in cells

Meiotic recombination checkpoint (3,047 words) [view diff] exact match in snippet view article find links to article

are required for progression through meiosis and sporulation. The DNA-binding domain of Ndt80 has been isolated, and the structure reveals that this protein

DM domain (575 words) [view diff] exact match in snippet view article find links to article

1101/gad.14.14.1750. PMC 316782. PMID 10898790. "Proteins matched: DM DNA-binding domain (IPR001275) filtered by species (Homo sapiens)". InterPro. "Family:

RAR-related orphan receptor alpha (2,662 words) [view diff] exact match in snippet view article find links to article

DNA-binding domain containing two zinc fingers, a hinge domain, and a C-terminal ligand-binding domain. Within the ROR family, the DNA-binding domain

TetR (981 words) [view diff] exact match in snippet view article find links to article

binds this cavity, it causes a conformational change that affects the DNA-binding domain so that TetR is no longer able to bind DNA. As a result, TetA and

ELF4 (602 words) [view diff] no match in snippet view article find links to article

(October 1996). "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties". Oncogene. 13

Enhanceosome (558 words) [view diff] no match in snippet view article find links to article

Double-stranded DNA is shown in green and pink; the ATF-2/c-Jun coiled-coil DNA binding domain is shown in purple; interferon response factors are shown in beige;

SOX5 (773 words) [view diff] no match in snippet view article find links to article

v t e PDB gallery 1i11: SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN, SOX-5 HMG BOX FROM MOUSE

Heat shock factor (743 words) [view diff] no match in snippet view article find links to article

HSF-type DNA-binding Structure of the dimeric DNA binding domain of the yeast heat shock factor (cyan and green) bound to DNA (brown) based on PDB: 3HTS

Pho4 (859 words) [view diff] exact match in snippet view article find links to article

indispensable for transcription of the PHO5, PHO81 and PHO84 genes. The DNA-binding domain of PHO4 consists of two helices, designated H1 and H2, separated by

TEAD3 (590 words) [view diff] exact match in snippet view article find links to article

(TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4.

B3 (489 words) [view diff] exact match in snippet view article find links to article

classification for blind sport B3 domain, a highly conserved plant DNA-binding domain Procyanidin B3, a plant phenolic compound ATC code B03 Antianemic

CodY protein family (151 words) [view diff] no match in snippet view article find links to article

CodY c-terminal dna binding domain of transcriptional pleiotropic repressor cody. Identifiers Symbol CodY Pfam PF06018 Pfam clan CL0161 InterPro IPR010312

FOXI1 (714 words) [view diff] no match in snippet view article find links to article

transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family". Proceedings of the National Academy of Sciences of the United

KMT2C (958 words) [view diff] exact match in snippet view article find links to article

leukemia (MLL) family and encodes a nuclear protein with an AT-hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain

Sp4 transcription factor (920 words) [view diff] no match in snippet view article find links to article

v t e PDB gallery 1va1: Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 1)

HSF4 (741 words) [view diff] exact match in snippet view article find links to article

Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X (Jun 2002). "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner

Sp2 transcription factor (801 words) [view diff] exact match in snippet view article find links to article

carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity

Extraskeletal myxoid chondrosarcoma (1,554 words) [view diff] exact match in snippet view article find links to article

including EWSR1, the transactivation domain of EWSR1 is fused to the DNA-binding domain of NR4A3. Several types of fusion products can be observed, depending

Pioneer factor (2,798 words) [view diff] exact match in snippet view article find links to article

head box factors (which contain a winged helix DNA-binding domain that mimics the DNA-binding domain of the linker H1 histone), and NF-Y (whose NF-YB

E2F5 (1,232 words) [view diff] no match in snippet view article find links to article

are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation

Interferon regulatory factors (1,098 words) [view diff] no match in snippet view article find links to article

regulatory factor transcription factor interferon regulatory factor-2 dna binding domain, nmr, minimized average structure Identifiers Symbol IRF Pfam PF00605

Epstein–Barr virus nuclear antigen 1 (997 words) [view diff] exact match in snippet view article find links to article

Epstein Barr virus nuclear antigen-1, DNA-binding domain Identifiers Symbol EBV-NA1 Pfam PF02905 InterPro IPR004186 SCOP2 1b3t / SCOPe / SUPFAM

RFX5 (1,239 words) [view diff] exact match in snippet view article find links to article

of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants

HOXB5 (1,048 words) [view diff] exact match in snippet view article find links to article

Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome

SOX13 (1,013 words) [view diff] no match in snippet view article find links to article

v t e PDB gallery 1i11: SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN, SOX-5 HMG BOX FROM MOUSE

SNAPC4 (533 words) [view diff] no match in snippet view article find links to article

RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal

THAP6 (434 words) [view diff] exact match in snippet view article find links to article

2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10

Centromere protein B (1,175 words) [view diff] no match in snippet view article find links to article

at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric

KLF5 (1,187 words) [view diff] exact match in snippet view article find links to article

oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB

POU2F3 (523 words) [view diff] case mismatch in snippet view article find links to article

gallery 1pou: THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN

NFATC1 (1,107 words) [view diff] no match in snippet view article find links to article

1a66: SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES 1nfa: HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR, 10 STRUCTURES

Li–Fraumeni syndrome (2,097 words) [view diff] exact match in snippet view article find links to article

TP53 mutations, the majority of which are missense mutations in the DNA-binding domain. These missense mutations cause a decrease in the ability of p53 to

THAP2 (388 words) [view diff] exact match in snippet view article find links to article

2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10

PAX9 (1,470 words) [view diff] no match in snippet view article find links to article

a PAX9 gene suggests that the loss of function due to the absence DNA binding domain is a mechanism that causes oligodontia. Those who express the PAX9

THAP4 (444 words) [view diff] exact match in snippet view article find links to article

2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10

JARID1B (1,072 words) [view diff] exact match in snippet view article find links to article

Whitson R, Itakura K, Chen Y (August 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry. 40 (31): 9142–50. doi:10

E2F2 (1,241 words) [view diff] no match in snippet view article find links to article

domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation

Estrogen-related receptor beta (800 words) [view diff] no match in snippet view article find links to article

v t e PDB gallery 1lo1: ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA

CEBPE (1,130 words) [view diff] no match in snippet view article find links to article

Koeffler HP (May 1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters"

ELK1 (2,465 words) [view diff] exact match in snippet view article find links to article

Alternative splicing produces ∆Elk1. This variant lacks part of the DNA-binding domain that allows interaction with SRF. On the other hand, sElk1 has an

RNA-binding protein EWS (1,750 words) [view diff] exact match in snippet view article find links to article

I, de Jong P, Rouleau G (October 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359

MAF (gene) (1,273 words) [view diff] exact match in snippet view article

Robinson PN, Sperling K, Singh JR (Mar 2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract"

SNAPC3 (568 words) [view diff] no match in snippet view article find links to article

RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal

TCF3 (1,186 words) [view diff] no match in snippet view article find links to article

Baltimore D (February 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell. 60 (4):

Germ cell nuclear factor (1,010 words) [view diff] no match in snippet view article find links to article

embryonic function of germ cell nuclear factor is dependent on the DNA binding domain". The Journal of Biological Chemistry. 277 (52): 50660–7. doi:10.1074/jbc

E2F3 (1,222 words) [view diff] no match in snippet view article find links to article

domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation

THAP7 (403 words) [view diff] exact match in snippet view article find links to article

2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10

ID3 (gene) (1,271 words) [view diff] exact match in snippet view article

of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers

Protein AATF (1,226 words) [view diff] no match in snippet view article find links to article

shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis

ZBP1 (2,535 words) [view diff] exact match in snippet view article find links to article

Z-DNA-binding domains (Zα and Zβ) at its N-terminus along with a DNA binding domain (D3). The role of ZBP1 in DNA sensing has been questioned. It has

CII protein (1,610 words) [view diff] exact match in snippet view article find links to article

motif (15), located between residues 26 and 45. On either side of the DNA-binding domain are domains crucial for tetramer formation, located in residues 9-25

IRF6 (1,547 words) [view diff] exact match in snippet view article find links to article

Family members share a highly conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The function

SNAPC2 (641 words) [view diff] no match in snippet view article find links to article

RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal

Zinc finger transcription factor (561 words) [view diff] exact match in snippet view article find links to article

upregulate the expression of the gene(s) in question while using the same DNA-binding domain. The expression of a gene can also be downregulated by blocking elongation

HMGA1 (1,511 words) [view diff] exact match in snippet view article find links to article

2005.12.002. PMID 16403635. Reeves R, Nissen MS (May 1990). "The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide

FOXA2 (1,552 words) [view diff] exact match in snippet view article find links to article

pioneering property is conferred by the factors’ highly conserved DNA-binding domain, which is structurally similar to the linker histones H1 and H5 This

TANGO2 (1,368 words) [view diff] no match in snippet view article find links to article

227 245 - GCMF Chorion-specific transcription factors (with a GCM DNA binding domain) 151 165 - YBXF Y-box binding transcription factors 158 170 - RUSH

SAND DNA-binding protein domain (377 words) [view diff] no match in snippet view article find links to article

SAND remains to be determined. Nevertheless, it is thought to be a DNA binding domain despite its beta structure. This function can be inferred by studying

PIAS3 (2,265 words) [view diff] no match in snippet view article find links to article

cells. This interaction is mediated via PIAS3 binding to the STAT3 DNA binding domain. Hence, STAT3 transcriptional activity is inhibited by the physical

ESAM (gene) (519 words) [view diff] exact match in snippet view article

"The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in

ZFP161 (559 words) [view diff] exact match in snippet view article find links to article

et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc

FOXP2 (5,881 words) [view diff] exact match in snippet view article find links to article

mutation causing an arginine-to-histidine substitution (R553H) in the DNA-binding domain is thought to be the abnormality in KE. This would cause a normally

TRIM16 (525 words) [view diff] exact match in snippet view article find links to article

gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant". Mol. Endocrinol. 12 (11): 1733–48. doi:10.1210/mend.12.11

DUXAP8 (118 words) [view diff] exact match in snippet view article find links to article

involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene

Estrogen-related receptor gamma (1,243 words) [view diff] no match in snippet view article find links to article

constitutively active conformation 1lo1: ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA 1s9p: crystal structure of the ligand-binding

SNAPC1 (713 words) [view diff] no match in snippet view article find links to article

et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". J. Biol

POLR2A (1,339 words) [view diff] exact match in snippet view article find links to article

in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed

BZIP Maf (255 words) [view diff] exact match in snippet view article find links to article

A, Yamamoto M, Tanaka T (April 2002). "Solution structure of the DNA-binding domain of MafG". Nat. Struct. Biol. 9 (4): 252–6. doi:10.1038/nsb771. PMID 11875518

Myocyte-specific enhancer factor 2A (1,449 words) [view diff] exact match in snippet view article find links to article

genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM] Myocyte-specific enhancer factor 2A has been shown

NRF1 (1,451 words) [view diff] exact match in snippet view article find links to article

activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators". Genes Dev. 7 (12A):

Single-stranded binding protein (1,016 words) [view diff] no match in snippet view article find links to article

Waksman G (June 1997). "Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined

PBX1 (1,819 words) [view diff] no match in snippet view article find links to article

Baltimore D (February 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell. 60 (4):

KLF11 (1,397 words) [view diff] exact match in snippet view article find links to article

two putative nuclear localization signals within the zinc finger DNA-binding domain". Journal of Cellular Biochemistry. 101 (3): 712–22. doi:10.1002/jcb

Catabolite Control Protein A (464 words) [view diff] no match in snippet view article find links to article

forms a "regulatory" domain. A short linker connects the N-terminal DNA binding domain and the C-terminal regulatory domain, which partially contacts DNA

BED zinc finger (297 words) [view diff] exact match in snippet view article find links to article

containing 5 Aravind L (September 2000). "The BED finger, a novel DNA-binding domain in chromatin-boundary-element-binding proteins and transposases".

PAX2 (1,868 words) [view diff] no match in snippet view article find links to article

Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain". ACS Chemical Biology. 12 (3): 724–734. doi:10.1021/acschembio.6b00782

Serum response factor (1,718 words) [view diff] exact match in snippet view article find links to article

interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1". J. Biol. Chem. 276 (13): 10413–22

NUCKS1 (662 words) [view diff] exact match in snippet view article find links to article

PMID 12368243. Grundt K, Skjeldal L, Anthonsen HW, et al. (2002). "A putative DNA-binding domain in the NUCKS protein". Arch. Biochem. Biophys. 407 (2): 168–75. doi:10

IRF1 (1,827 words) [view diff] no match in snippet view article find links to article

IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, which is highly conserved among all IRF proteins. Beyond its function

Keratinocyte (2,756 words) [view diff] exact match in snippet view article find links to article

cells from differentiating into keratinocytes. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft

Transcription factor IIIB 50 kDa subunit (515 words) [view diff] no match in snippet view article find links to article

et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". J. Biol

RNA polymerase II (3,100 words) [view diff] no match in snippet view article find links to article

with several other polymerase subunits, the RPB1 subunit forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed

MTA3 (1,763 words) [view diff] exact match in snippet view article find links to article

v t e PDB gallery 2crg: Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein

Estrogen-related receptor alpha (1,995 words) [view diff] no match in snippet view article find links to article

v t e PDB gallery 1lo1: ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA 1xb7: X-ray structure of ERRalpha LBD in complex with a PGC-1alpha

Protein fold class (961 words) [view diff] no match in snippet view article find links to article

domain, the beta-propeller domain, the immunoglobulin fold and B3 DNA binding domain. α+β proteins are a class of structural domains in which the secondary

Leucine zipper (2,049 words) [view diff] no match in snippet view article find links to article

Another DNA binding domain, the Helix-loop-helix (HLH) dimer, is shown bound to DNA fragment — each alpha helix represents a monomer.

EGR1 (1,496 words) [view diff] exact match in snippet view article find links to article

fibrosis in mice. It may also be involved in ovarian function The DNA-binding domain of EGR-1 consists of three zinc finger domains of the Cys2His2 type

ETS1 (1,811 words) [view diff] exact match in snippet view article find links to article

Joubert I, de Jong P, Rouleau G (Sep 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359

DEK (gene) (1,036 words) [view diff] case mismatch in snippet view article

v t e PDB gallery 1q1v: Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif

GLI1 (2,311 words) [view diff] no match in snippet view article find links to article

[Y/F]JXCX3GCX3[F/Y]X5LX2HX4H[T/S]GEKP. The Gli1 and Gli2 protein zinc finger DNA binding domain have been shown to bind to the DNA consensus GLI binding site GACCACCCA

Thyroid hormone receptor beta (1,743 words) [view diff] case mismatch in snippet view article find links to article

Hormone Receptor Interactions 2h6w: 2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA

Monodnaviria (3,019 words) [view diff] exact match in snippet view article find links to article

inactivation of the endonuclease's HUH domain. The HUH domain then became a DNA-binding domain. At the same time, these viruses' manner of replication changed from

RFC1 (2,249 words) [view diff] no match in snippet view article find links to article

SH (September 1998). "DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C". Nucleic Acids Research

Protein SET (1,281 words) [view diff] exact match in snippet view article find links to article

oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb

Chromosome 2 (2,534 words) [view diff] no match in snippet view article find links to article

Rna binding motif protein 44 RFX8: Rfx family member 8, lacking rfx dna binding domain RIF1: replication timing regulatory factor 1 RNU4ATAC: RNA, U4atac

Ecdysone receptor (1,037 words) [view diff] exact match in snippet view article find links to article

namely an N-terminal transcriptional activation domain (A/B domain), a DNA-binding domain (C domain, highly conserved between receptors), a linker region (D

Protein SET (1,281 words) [view diff] exact match in snippet view article find links to article

oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb

PATZ1 (1,015 words) [view diff] no match in snippet view article find links to article

for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription

SFPQ (1,243 words) [view diff] no match in snippet view article find links to article

novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and Cellular Biology. 21

Arginine repressor ArgR (391 words) [view diff] no match in snippet view article find links to article

Arginine repressor, DNA binding domain Identifiers Symbol Arg_repressor Pfam PF01316 SCOP2 1aoy / SCOPe / SUPFAM

LuxR-type DNA-binding HTH domain (877 words) [view diff] exact match in snippet view article find links to article

Ruterjans H, Bernhard F (May 2003). "Structural analysis of the DNA-binding domain of the Erwinia amylovora RcsB protein and its interaction with the

GT198 (2,345 words) [view diff] exact match in snippet view article find links to article

protein with its monomer contains 217 amino acids. It comprises a DNA-binding domain and forms a protein homodimer or heterodimer. GT198 protein binds

TP63 (2,377 words) [view diff] exact match in snippet view article find links to article

EEC-patient-derived skin keratinocytes carrying heterozygous p63 DNA-binding domain mutations as the cellular model to characterize the global gene regulatory

TBX6 (610 words) [view diff] exact match in snippet view article find links to article

a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the

Tetrapeptide repeat homeobox 1 (121 words) [view diff] exact match in snippet view article find links to article

involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene

Constitutive androstane receptor (2,238 words) [view diff] no match in snippet view article find links to article

Moore DD (May 1996). "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors". Science. 272 (5266): 1336–9

KDM2A (956 words) [view diff] no match in snippet view article find links to article

based mechanism. It has recently been demonstrated that a ZF-CxxC DNA binding domain within FBXL11/KDM2A has the capacity to interact with non-methylated

RUNX2 (2,246 words) [view diff] exact match in snippet view article find links to article

member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for osteoblastic differentiation and skeletal morphogenesis

Hormone receptor (2,015 words) [view diff] exact match in snippet view article find links to article

Katherine; Green, Douglas R.; Kriwacki, Richard W. (2014-06-01). "The DNA-binding domain mediates both nuclear and cytosolic functions of p53". Nature Structural

BCL-6 corepressor (1,146 words) [view diff] no match in snippet view article find links to article

Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction

M. Radhakrishna Pillai (scientist) (1,436 words) [view diff] exact match in snippet view article

Ramkumar; Radhakrishna Pillai, M. (2006). "Homology modeling of the DNA-binding domain of human Smad5: a molecular model for inhibitor design". Journal of

Frank Rauscher III (489 words) [view diff] exact match in snippet view article find links to article

Sykes SM, Rauscher FJ, Schultz DC, McMahon SB., Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis., Journal of Biological Chemistry

PARP2 (1,307 words) [view diff] no match in snippet view article find links to article

to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl)

TADA2L (1,104 words) [view diff] no match in snippet view article find links to article

v t e PDB gallery 1x41: Solution structure of the Myb-like DNA binding domain of human Transcriptional adaptor 2-like, isoform B 2aqe: Structural and functional

MBD1 (1,240 words) [view diff] exact match in snippet view article find links to article

Tsuruzoe S, Ohki I, Shirakawa M, Kawasuji M, Nakao M (2004). "Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression

PAWR (1,352 words) [view diff] no match in snippet view article find links to article

putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis

Designer baby (9,030 words) [view diff] exact match in snippet view article find links to article

Zinc-finger nucleases (ZFNs) are enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger recognizes between 9 and 18

Peroxisome proliferator-activated receptor gamma (2,091 words) [view diff] no match in snippet view article find links to article

self-association retinoid X receptor binding protein heterodimerization activity DNA binding domain binding LBD domain binding DNA-binding transcription factor activity

Molecular tweezers (1,944 words) [view diff] no match in snippet view article find links to article

Lys-specific molecular tweezer, CLR01, modulates aggregation of mutant p53 DNA binding domain and inhibits its toxicity, Biochemistry, 2015; 54: 3729–3738. E Lump

Peptidoglycan recognition protein 2 (4,715 words) [view diff] exact match in snippet view article find links to article

contains intrinsically disordered region with hepatitis B virus (HBV) DNA-binding domain. The C-terminal segment is also longer than in other mammalian PGLYRPs

Newcomb Cleveland Prize (217 words) [view diff] no match in snippet view article find links to article

Hypothetical Structure Common to a New Class of DNA Binding Proteins The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite 1987 Margaret

MED15 (1,614 words) [view diff] no match in snippet view article find links to article

Piskacek M (November 2009). "9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons)". Nature Precedings. doi:10.1038/npre

DpnI (512 words) [view diff] no match in snippet view article find links to article

comprises an N-terminal catalytic domain and a C-terminal winged helix DNA binding domain, both of which show specificity for the methylated GATC sequence.

Hepatocyte nuclear factors (585 words) [view diff] exact match in snippet view article find links to article

disease: MODY 5) The HNF3 subfamily members contain a winged helix DNA-binding domain and bind to DNA as monomers. HNF3α/FOXA1 (forkhead box A1) HNF3β/FOXA2

RUNX1 (3,635 words) [view diff] no match in snippet view article find links to article

T-ALL patients have RUNX1 mutations which are clustered around the DNA binding domain of RUNX1. Those mutations are proposed to cause loss-of-function and

TALE-likes (3,029 words) [view diff] no match in snippet view article find links to article

related strains differ in the composition of repeats that make up their DNA binding domain. Repeat composition determines DNA binding preference. In particular

HNRPU (1,291 words) [view diff] exact match in snippet view article find links to article

binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA

Ewing sarcoma (4,387 words) [view diff] exact match in snippet view article find links to article

de Jong P, Rouleau G (September 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359

IRF9 (1,005 words) [view diff] exact match in snippet view article find links to article

localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors". Proc. Natl. Acad

Jrk (1,281 words) [view diff] no match in snippet view article find links to article

regulate transcription. This domain is a 60 amino acid region with a DNA binding domain, which is followed by two amphipathic alpha-helices which are connected

VapBC (1,268 words) [view diff] exact match in snippet view article find links to article

own operon, repressing transcription of both components through a DNA-binding domain in VapB. In some organisms, vapBC loci have been assigned other potential

MTA1 (3,836 words) [view diff] exact match in snippet view article find links to article

v t e PDB gallery 2crg: Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein

Ectrodactyly–ectodermal dysplasia–cleft syndrome (2,617 words) [view diff] no match in snippet view article find links to article

mutations associated with EEC "involve amino acid substitutions in the DNA binding domain common to all known p63 isoforms". The findings of their study propose

KDM2B (1,477 words) [view diff] no match in snippet view article find links to article

recognizes and bind non-methylated DNA in CpG islands through its ZF-CxxC DNA binding domain. KDM2B consequently recruits the non-canonical polycomb repressive

Gene knockout (2,563 words) [view diff] no match in snippet view article find links to article

Transcription activator-like effector nucleases (TALENs) also contain a DNA binding domain and a nuclease that can cleave DNA. The DNA binding region consists

SND1 (1,746 words) [view diff] no match in snippet view article find links to article

PMID 11124528. S2CID 46217878. Rushton JJ, Ness SA (2001). "The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb

STAT5A (1,831 words) [view diff] no match in snippet view article find links to article

facilitates protein-protein interactions for transcriptional regulation DNA binding domain (aa331-496): permits binding to consensus gamma-interferon activation

Homeobox (4,386 words) [view diff] no match in snippet view article find links to article

that this gene contained a 180 base pair sequence that encoded a DNA binding domain, which William McGinnis termed the "homeobox". The existence of additional

David Moore (biologist) (1,777 words) [view diff] no match in snippet view article

Gametchu, Bahiru; Goodman, Howard M. (June 1986). "Conservation of the DNA binding domain and other properties between porcine and rat glucocorticoid receptors"

Pdr1p (1,267 words) [view diff] exact match in snippet view article find links to article

protein-protein interaction via hydrogen bonding. A study found that DNA-binding domain of Pdr1p was sufficient for recognizing its endogenous target genes

USF1 (4,538 words) [view diff] exact match in snippet view article find links to article

induces a conformational change of the USF protein and exposes its DNA-binding domain for interaction. This increased structural exposure enhances DNA binding

ZNF839 (1,473 words) [view diff] no match in snippet view article find links to article

modification. In addition, it was found that when a C2H2-zinc finger and p53 DNA binding domain fusion transcription factor was created, it increased the transcription

Transposon mutagenesis (2,213 words) [view diff] exact match in snippet view article find links to article

the entire system, and Inh encodes an inhibitor of transposase. The DNA-binding domain of Tnp resides in the 55 N-terminal amino acids, and so these residues

Meganuclease (2,295 words) [view diff] no match in snippet view article find links to article

meganucleases for genome engineering is the incorporation of the DNA binding domain from transcription activator-like (TAL) effectors into hybrid nucleases

Arc system (1,366 words) [view diff] no match in snippet view article find links to article

alpha helices, and six beta sheets. Amino acids 134-234 have the DNA binding domain which can activate or suppress gene expression. There are 76 DNA binding

Sex-determining region Y protein (5,172 words) [view diff] exact match in snippet view article find links to article

domain, which contains nuclear localization sequences and acts as the DNA-binding domain. The C-terminal domain has no conserved structure, and the N-terminal

Homing endonuclease (2,573 words) [view diff] exact match in snippet view article find links to article

Roey, P.; Fox, KM; et al. (July 2001). "Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate". EMBO J. 20 (14):

Q-system (genetics) (1,520 words) [view diff] no match in snippet view article

HACK system to convert existing GAL4 transgenic insertions to QF2. DNA binding domain of QF2 fused with VP16 transcriptional activator domain was successfully

Optogenetics (11,930 words) [view diff] exact match in snippet view article find links to article

to a DNA-binding domain and PIF to a transcriptional activation domain, transcriptional activation of genes recognized by the DNA-binding domain could

Simiispumavirus pantrosch (4,440 words) [view diff] no match in snippet view article find links to article

transcription activation domain at its C-terminus and a centrally located DNA binding domain. The Bet protein is required for viral replication, as it counteracts

DnaA (4,283 words) [view diff] no match in snippet view article find links to article

PMC 4696014. PMID 23746253. Roth A, Messer W (May 1995). "The DNA binding domain of the initiator protein DnaA". The EMBO Journal. 14 (9): 2106–2111

PROX1 (1,103 words) [view diff] no match in snippet view article find links to article

sequence-specific DNA binding transcription corepressor activity DNA binding domain binding DNA-binding transcription factor activity LBD domain binding

Non-POU domain-containing octamer-binding protein (2,467 words) [view diff] no match in snippet view article find links to article

novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and Cellular Biology. 21

Protein–protein interaction (8,383 words) [view diff] exact match in snippet view article find links to article

expression constructs are made: one protein (X) is fused to the Gal4 DNA-binding domain (DB) and a second protein (Y) is fused to the Gal4 activation domain

FAM110A (772 words) [view diff] exact match in snippet view article find links to article

00 EVI1-myleoid transforming protein MEL1 (MDS1/EVI1-like gene 1) DNA-binding domain 2 612 628 (-) 1.00 C2H2 zinc finger transcription factors 37 Zinc

Papillomaviridae (7,370 words) [view diff] no match in snippet view article find links to article

by a relatively unstructured hinge region to a well-characterized DNA binding domain. E2 facilitates the binding of E1 to the viral origin of replication

Single-strand DNA-binding protein (425 words) [view diff] no match in snippet view article find links to article

Waksman G (June 1997). "Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined

Transactivation domain (2,777 words) [view diff] no match in snippet view article find links to article

transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain". Cell. 58 (4): 741–53. doi:10.1016/0092-8674(89)90108-6. PMID 2504497

Rhabdomyosarcoma (5,953 words) [view diff] no match in snippet view article find links to article

commonly, t(1;13)(p36, q15). Both involve the translocation of a DNA binding domain of either PAX3 or PAX7, a member of the Paired Box family of transcription

Hox gene (6,108 words) [view diff] exact match in snippet view article find links to article

referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox)

ZSWIM9 (2,146 words) [view diff] exact match in snippet view article find links to article

protein-DNA or protein-protein interactions. There is a conserved FAR1 DNA-binding domain from amino acids 97-128. This indicates that ZSWIM9, a member of the

Nicotinamide ribonucleoside uptake transporters (1,421 words) [view diff] no match in snippet view article find links to article

NR uptake occur in the C-terminal part of NadR. A helix-turn-helix DNA binding domain present in NadR of S. enterica serovar Typhimurium could not be found

Gal4 transcription factor (2,205 words) [view diff] no match in snippet view article find links to article

PMID 1557122. S2CID 4344434. Pan T, Coleman JE (March 1990). "The DNA binding domain of GAL4 forms a binuclear metal ion complex". Biochemistry. 29 (12):

Myocardin (1,821 words) [view diff] exact match in snippet view article find links to article

The SAP DNA-binding domain is shown in purple and spans amino acids 541–807. The basic region, in turquoise, spans amino acids 280-295. The glutamine-rich

Zinc finger protein 226 (3,870 words) [view diff] exact match in snippet view article find links to article

domain that determines DNA sequence recognition suggests a novel DNA-binding domain". Genes & Development. 9 (8): 984–94. doi:10.1101/gad.9.8.984. PMID 7774815

CRISPR activation (2,739 words) [view diff] no match in snippet view article find links to article

a process called transcription. Transcriptional activators have a DNA binding domain and a domain for activation of transcription. The activation domain

ZNF821 (1,223 words) [view diff] exact match in snippet view article find links to article

nuclear localization signal. This STPR domain is a double-stranded DNA-binding domain with similar traits to the silkworm FMBP-1 STPR domain and is thought

Wafik El-Deiry (3,601 words) [view diff] exact match in snippet view article find links to article

the tumor suppressor p53. Nikola Pavletich later crystallized the DNA-binding domain of p53 with the DNA binding site and showed that p53 amino acid residues

NBPF1 (2,276 words) [view diff] no match in snippet view article find links to article

signals. These nuclear localization signals in NBPF1 and a conserved DNA binding domain similar to the transcription factor STAT3/dna complex or STAT1/dna

Ctenophora (12,514 words) [view diff] exact match in snippet view article find links to article

receptors from the ctenophore Mnemiopsis leidyi lack a zinc-finger DNA-binding domain: Lineage-specific loss or ancestral condition in the emergence of

Complete androgen insensitivity syndrome (7,058 words) [view diff] exact match in snippet view article find links to article

Wang TY, Wang W, Hwu YM (July 1999). "A frame shift mutation in the DNA-binding domain of the androgen receptor gene associated with complete androgen insensitivity

Protein engineering (7,486 words) [view diff] exact match in snippet view article find links to article

involves the fusion of a 3-methyladenine DNA glycosylase to tetR DNA-binding domain. This has been shown to increase mutation rates by over 800 time in

FAM43A (1,640 words) [view diff] no match in snippet view article find links to article

tagggagttGGGGggaggg GCMF Chorion-specific transcription factors with a GCM DNA binding domain 1742 - 0.919 attaCCCGcacctc SORY SOX/SORY sex/testes determining and

Deficiency of RbAp48 protein and memory loss (2,436 words) [view diff] no match in snippet view article find links to article

Piskacek, Martin (2009). "9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons)". Nature Precedings. doi:10.1038/npre

DNA-3-methyladenine glycosylase (2,620 words) [view diff] exact match in snippet view article find links to article

Ohki I, Shirakawa M, Kawasuji M, Nakao M (Oct 2003). "Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression

Steven McKnight (2,873 words) [view diff] no match in snippet view article find links to article

Landschulz, W. H.; Johnson, P. F.; McKnight, S. L. (1989-03-31). "The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite". Science. 243

FAN1 (1,817 words) [view diff] no match in snippet view article find links to article

This portion of FAN1 contains three domains: an SAP domain (primary-DNA binding domain), a TPR domain (mediating interdomain interaction and dimerization

Telomeric repeat-binding factor 2 (3,340 words) [view diff] case mismatch in snippet view article find links to article

1vfc: Solution Structure Of The DNA Complex Of Human Trf2 1w0u: HTRF2 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA. 1xg1: Solution structure of Myb-domain

Genetic engineering techniques (6,765 words) [view diff] no match in snippet view article find links to article

the best features of both (e.g. megaTAL that are a fusion of a TALE DNA binding domain and a meganuclease). Recent research has also focused on developing

Jan-Åke Gustafsson (1,330 words) [view diff] no match in snippet view article find links to article

fragment, first determination a 3-D structure of a nuclear receptor (the DNA binding domain of the glucocorticoid receptor), discovery of the first physiological

ADAR (4,802 words) [view diff] no match in snippet view article find links to article

Alfken J, Kim YG, Mian IS, Nishikura K, Rich A (August 1997). "A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine

Zinc finger nuclease treatment of HIV (3,400 words) [view diff] exact match in snippet view article find links to article

(1989). "Three-dimensional solution structure of a single zinc finger DNA-binding domain". Science. 245 (4918): 635–637. Bibcode:1989Sci...245..635L. doi:10

TMEM155 (1,208 words) [view diff] exact match in snippet view article find links to article

interactive domain 1B 1083 GCACagcgc EVI1 MEL1 (MDS1/EVI1-like gene 1) DNA-binding domain 2 139 cagtgaaGATGgggtct SMAD Smad3 transcription factor involved in

SKIDA1 (2,216 words) [view diff] exact match in snippet view article find links to article

proteins Ski, Ski-like protein, and dachshund. It is potentially a DNA-binding domain. The other domain, DUF4854, is also found in EPOP, near its C-terminus

Regulator gene glucosyltransferases (Rgg/SHP) systems (1,131 words) [view diff] no match in snippet view article

homodimers, and each monomer has two functional domains: an N-terminal DNA binding domain with a helix-turn-helix (HTH) motif, and a C-terminal peptide binding

Catenin beta-1 (12,347 words) [view diff] no match in snippet view article find links to article

the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. Plakoglobin (also called γ-catenin)

Synechocystis sp. PCC 6803 (3,536 words) [view diff] exact match in snippet view article find links to article

trees of individual TF family, multiple sequence alignments of the DNA-binding domain and ortholog identification from any selected genomes. Archean Eon

Systematic evolution of ligands by exponential enrichment (4,747 words) [view diff] exact match in snippet view article find links to article

system – Method for identifying the sequence-specific target site of a DNA-binding domain Hak-Hagir A (1978). "[The Hak-Hagir skin conduit]". Zeitschrift für

BEND2 (protein) (1,817 words) [view diff] exact match in snippet view article

Lai EC (March 2013). "The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors". Genes & Development

MECOM (4,864 words) [view diff] no match in snippet view article find links to article

may be regulated by phosphorylation of serine196, in its N-terminal DNA binding domain. All of these involve erratic cellular development and differentiation

THAP3 (2,330 words) [view diff] exact match in snippet view article find links to article

2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends in Biochemical Sciences. 28 (2):

Small Maf (3,041 words) [view diff] exact match in snippet view article find links to article

M706863200. PMID 17875642. Kusunoki, H (2002). "Solution structure of the DNA-binding domain of MafG". Nat. Struct. Biol. 9 (4): 252–6. doi:10.1038/nsb771. PMID 11875518

Orphan gene (4,621 words) [view diff] exact match in snippet view article find links to article

of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain". The Journal of Biological Chemistry. 273 (43): 28504–28509. doi:10

Anticancer gene (6,791 words) [view diff] exact match in snippet view article find links to article

with the CTD. This domain also aids in the binding of the central DNA-binding domain (DBD) to specific DNA sequences; the CTD is a positive regulator of

Nucleoid (17,312 words) [view diff] no match in snippet view article find links to article

CadC. CadC contains a periplasmic sensory domain and a cytoplasmic DNA binding domain. Sensing of an acidic environment by its periplasmic sensory domain

Robert Clarke (academic) (2,910 words) [view diff] exact match in snippet view article

William L. (December 10, 2006). "Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity

Multiple Epidermal Growth Factor-like Domains 8 (3,523 words) [view diff] no match in snippet view article find links to article

TATA-less promoters Chorion-specific transcription factors with a GCM DNA binding domain Signal transducer and activator of transcription Heat shock factors

CUX1 (4,649 words) [view diff] exact match in snippet view article find links to article

91:7757–61. Andres V, Chiara MD, and Mahdavi V. "A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of

Kevin Struhl (4,611 words) [view diff] exact match in snippet view article find links to article

Harrison, Stephen C; Struhl, Kevin (1990). "Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA". Nature. 347 (6293): 575–578.

Protein acetylation (4,899 words) [view diff] no match in snippet view article find links to article

cell undergoes stress. Acetylation sites have been observed on the DNA binding domain (K164 and K120) and the C terminus. Acetylation sites demonstrate

C6orf118 (2,735 words) [view diff] exact match in snippet view article find links to article

combines the transcriptional activation domain of EWSR1 with the DNA-binding domain of FLI1. EWSR1-FLI1 deregulate genes involved in tumorigenesis. Thus

Loop extrusion (5,226 words) [view diff] exact match in snippet view article find links to article

that can be randomly encountered on the DNA. CTCF: The C-terminal DNA-binding domain of CTCF has been shown to directly interact with SA2 and SCC1 subunits

Non-canonical base pairing (11,719 words) [view diff] no match in snippet view article find links to article

Ethayathulla A, Tse P, Nguyen S, Viadiu H (2012). "Structure of p73 DNA binding domain tetramer modulates p73 transactivation". Proceedings of the National