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searching for De novo synthesis 91 found (145 total)

alternate case: de novo synthesis

Guanosine monophosphate (567 words) [view diff] no match in snippet view article find links to article

Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer

inhibition and modulation. There are at least 2 known steps in the de novo synthesis of myo-inositol from glucose 6-phosphate. In the first step, glucose

cancer. Amrubicin was the first anthracycline derivative created by de novo synthesis and was first published in 1989 by scientists from Sumitomo. Ueoka

cyclo-ligase (AIR synthetase) is the fifth enzyme (EC 6.3.3.1) in the de novo synthesis of purine nucleotides. It catalyzes the reaction to form 5-aminoimidazole

converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which

(CAD) Pyrimidine-De-Novo-Synthesis CTP synthase (CTPS) Pyrimidine-De-Novo-Synthesis FGAR amidotransferase Purine-De-Novo-Synthesis Guanosine monophosphate

enzyme involved in the first three steps of pyrimidine biosynthesis. De-novo synthesis starts with cytosolic carbamoylphosphate synthetase II which uses

(lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering

commonly referred to as a long-chain base (LCB), which is N-acylated. De novo synthesis of LCBs begins with the condensation of palmitoyl-CoA with serine

PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction

single double bond between the C9 and C10 of long-chain acyl-CoAs from de-novo synthesis. This enzyme belongs to the family of oxidoreductases, specifically

cytoskeleton, including flagella. This "transformation" includes de novo synthesis of basal bodies (or centrioles). It was first characterized in 1899

DHOQOs is both part of the electron transport chain and the pyrimidine de novo synthesis, it has been explored as a possible target for cancer treatment, immunological

purH, which catalyzes the formylation of the intermediate AICAR in de novo synthesis of purines. The formyl group is taken from formyltetrahydrofolate

undecaprenyl phosphate. This type of synthesis is referred to as de novo synthesis where a complex molecule is created from simpler molecules as opposed

bonded to carbon-2, and a phosphate group bonded to carbon-3. Besides de novo synthesis, PA can be formed in three ways: By phospholipase D (PLD), via the

PRPP is essential for both the de novo synthesis of purines and for the purine salvage pathway. The de novo synthesis pathway begins with the activation

dihydroorotate dehydrogenase (DHODH), which plays a key role in the de novo synthesis of uridine monophosphate (rUMP), which is required for the synthesis

and phospholipid synthesis, a high rate of pyrimidine and purine de novo synthesis, a low ratio of Adenosine triphosphate and Guanosine triphosphate

from genetic mutation in the gyrB subunit. Other mechanisms include de novo synthesis of a coumarin-resistant gyrase B subunit by the novobiocin producer

Lirentelimab inhibits mast cells' IgE-mediated degranulation and de novo synthesis of prostaglandin D2 in vitro. Mild-to-moderate infusion reactions

"in recognition of methods he developed with colleagues to measure de novo synthesis of amyloid-beta (Abeta)." Bennett is the principal investigator of

transcarbamylase is one of the first three enzymes necessary for de novo synthesis of pyrimidine nucleotides, and after Stark was able to isolate this

Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy

mediated response and production of second messenger, without need for de novo synthesis of any neurotransmitters. Noble F, Smadja C, Valverde O, Maldonado

Reichard, P (1986). "Interrelations between substrate cycles and de novo synthesis of pyrimidine deoxyribonucleoside triphosphates in 3T6 cells". Proceedings

inhibitor of AChE and its inhibition of AChE is only overcome by de novo synthesis of new AChE in each tissue. The recovery of AChE activity in the brain

aminopeptidase. Two formylation reactions are required in the eleven step de novo synthesis of inosine monophosphate (IMP), the precursor of the purine ribonucleotides

kinase. + ATP → + ADP Glycerol 3-phosphate is a starting material for de novo synthesis of glycerolipids. In eukaryotes, it is first acylated on its sn-1

Garrido-Franco M (April 2003). "Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond". Biochimica et Biophysica Acta. 1647 (1–2):

Sphingomyelin de novo synthesis pathway

Kang S, Wang T, Gnanaprakasam JR, Yao Y, et al. (December 2020). "De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and

+ H+ → + NAD(P)+ Glycerol 1-phosphate is a starting material for de novo synthesis of ether lipids, such as those derived from archaeol and caldarchaeol

monophosphate (ThMP), the active form of thymidine which is required for the de novo synthesis of DNA. Uridine Triacetate is a potential antidote for cases of suspected

quickly from DNA through next generation sequencing technologies, de novo synthesis of DNA is a major bottleneck in the process. Only one nucleotide can

administration)), which is processed by cells to L-cysteine and used in the de novo synthesis of GSH. Cytochrome P450 oxidase Liver failure Centrilobular necrosis

Alternatively, mutations can be targeted to specific codons during de novo synthesis or saturation mutagenesis to construct one or more point mutants of

FNR in vivo. The formation of [4Fe–4S] FNR from apoFNR is part of de novo synthesis of active FNR. The reaction requires cysteine desulphurase which catalyzes

are toxic. 1-DeoxySLs has a similar pattern to sphingolipids during de novo synthesis. The reaction is catalyzed by the enzyme serine palmitoyltransferase

controlling the degradation rates of LAMP-2A monomers in lysosomes and by de novo synthesis of LAMP-2A molecules. In addition, transport of substrates also depends

reduction of sulfur and arsenic, were identified. Pathways for the de novo synthesis of nearly all required cofactors and metabolites were identified.

Chemotherapeutic agents such as daunorubicin and etoposide enhance the de novo synthesis of ceramide in studies done on mammalian cells. The same results were

Trebitsh, T; Goldschmidt, EE; Riov, J (1993). "Ethylene induces de novo synthesis of chlorophyllase, a chlorophyll degrading enzyme, in citrus fruit

infiltrated in the citric acid cycle is low and acetyl-CoA is available for de novo synthesis of fatty acids and cholesterol. The fatty acids can be used for phospholipid

while others maintain kinetosomes and/or microtubular structures. De novo synthesis of cyst wall precursors in the endoplasmic reticulum also frequently

B; Simmonds HA (1 August 1998). "Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans". Journal

Mita; Nobuhisa Fukuda; Motomu Kanai; Masakatsu Shibasaki (2006). "De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso-Aziridines

PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction

group and are referred to as 'amidated' pathways. The pathways for de novo synthesis from tryptophan and from NA salvage are 'deamidated' pathways, which

Stallforth, Pierre; Adibekian, Alexander; Seeberger, Peter H. (2008). "De Novo Synthesis of ad-Galacturonic Acid Thioglycoside as Key to the Total Synthesis

restricted. Gibellini F, Smith TK (Jun 2010). "The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine". IUBMB Life.

regulating substances – introduction of the gibberellic acid-induced de novo synthesis of hydrolytic enzymes in embryoless seeds of Triticum aestivum as

PC is primarily present as dipalmitoylphosphatidylcholine (DPPC). De novo synthesis of phosphatidylcholine in the lung arises primarily from cytidine

activity and psychostimulant effects of bromantane is activation of the de novo synthesis of dopamine via modulation of gene expression. A selection of quoted

053. Boger, Dale L.; Robarge, Kirk D. (1 November 1988). "Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder

tumors of childhood. TdT has also seen recent application in the De Novo synthesis of oligonucleotides, with TdT-dNTP tethered analogs capable of primer

only to phosphatidate. There are speculated to be involved in the de novo synthesis of glycerolipids. Each of the 3 Lipin proteins found in mammals—Lipin1

Krebs cycle, is converted to citrate and subsequently directed toward de novo synthesis of the free fatty acid palmitate. The first step in the metabolism

inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in the IMPDH1 gene are a cause of

total body pool, the lost creatine must be replaced from diet or de novo synthesis. Cannan RK, Shore A (1928). "The creatine-creatinine equilibrium.

and Lena H. Sun, July 6, 2017". Koblentz, Gregory D. (2017). "The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations

GDP-mannose 4,6-hydro-lyase. The enzyme is a part of the GDP-Fucose de novo synthesis pathway and catalyzes the first step in the process that gives us

and DNA. Pyrimidine biosynthesis can occur through two pathways: de novo synthesis, which relies on L-glutamine as the pathway precursor, and salvage

is the assimilation of single carbon units into biomass. Through de novo synthesis, methylotrophs must form carbon-carbon bonds between 1-Carbon ( C

function of OSM. Like many cytokines OSM is produced from cells by de novo synthesis followed by release through the classical secretion pathway. However

1021/ja0616433. PMID 16683783. S2CID 20852603. Fukuta, Yuhei (2006). "De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso -Aziridines

PMID 15189159. Ikawa Y, Tsuda K, Matsumura S, Inoue T (September 2004). "De novo synthesis and development of an RNA enzyme". Proceedings of the National Academy

Wang, Yong-Gang; Romo, Daniel; Molinski, Tadeusz F. (2012-04-27). "De Novo Synthesis of Benzosceptrin C and Nagelamide H from 7- 15 N-Oroidin: Implications

Trebitsh T, Goldschmidt EE, Riov J (October 1993). "Ethylene induces de novo synthesis of chlorophyllase, a chlorophyll degrading enzyme, in Citrus fruit

mostly by mitosis. Some features of their binary fission are the de novo synthesis of the bothrosome and the cytokinesis, that occurs by vesicle accumulation

dihydrofolate into tetrahydrofolate, a proton shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional

macrophages do not contain preformed IL-1α precursors, but instead rely on de novo synthesis. The IL-1α precursor is processed to its mature 17-kDa form by a Ca2+-activated

Rather, astrocytes produce and distribute cholesterol in the brain. De novo synthesis, both in astrocytes and hepatocytes, occurs by a complex 37-step process

Richard L.; Preston, Chris M.; Sawtell, Nancy M. (2009-03-01). "De novo synthesis of VP16 coordinates the exit from HSV latency in vivo". PLOS Pathogens

essential synthesis steps. Genetic mutations affecting the enzymes of the de novo synthesis pathway may possibly contribute to the disease, although these are

expression of the telomerase coding gene so that they can initiate a de novo synthesis of telomere sequences at internal breakpoints, resulting in the stabilization

Tadashi; Badger, Murray (2008). "Heat stress causes inhibition of the de novo synthesis of antenna proteins and photobleaching in cultured Symbiodinium".

phosphatidylcholine containing specific fatty acids, but are not used for the de-novo synthesis of phosphatidylcholine. In contrast to these finding from rat liver

problematic and virtually precludes the possibility of performing a de novo synthesis of 'M. laboratorium', the origin of the attention in the popular press

inactive pumps after the drug has been eliminated from the blood, and de novo synthesis of new pumps. Although the drugs omeprazole, lansoprazole, pantoprazole

destroyed by combustion, their reformation by a process known as 'de novo synthesis' as the emission gases cool is a probable source of the dioxins measured

inhibitor of this enzyme. Thus, GNMT has been proposed to link the de novo synthesis of methyl groups to the ratio of SAM to SAH, which in turn serves

generate prostaglandins. It was demonstrated that the increase is due to de novo synthesis of fresh enzyme. In 1991, during the investigation of the expression

that inhibit the enzyme dihydrofolate reductase thus blocking the de novo synthesis of thymidine monophosphate. One such medium that is commonly used

to the initial culture, indicating that the algal cells utilized de novo synthesis of fatty acids. It is vital for the lipid content in algal cells to

the cell membrane, and sarcolemma is the one that relies mainly on de novo synthesis of cholesterol. This is important under stressful conditions when

Enrico; Wabitsch, Martin; Papadopoulos, Vassilios (January 2014). "De Novo Synthesis of Steroids and Oxysterols in Adipocytes". Journal of Biological Chemistry

that this fatty acid is introduced to a large extent through the de novo synthesis of phosphatidic acid. His laboratory later identified an activating

pathways unrelated to thymidine, by the enzyme thymidylate synthase (De novo synthesis). This second route is used by the cell under normal conditions, and

needed for the viral RNA replication. Research has demonstrated that de novo synthesis of the NP and P proteins is essential for efficient viral transcription

from commercial suppliers which create oligonucleotides on demand by de novo synthesis. primer dimer (PD) primer walking priming The initiation of nucleic