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searching for De novo synthesis 91 found (144 total)

alternate case: de novo synthesis

Guanosine monophosphate (567 words) [view diff] no match in snippet view article find links to article

Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer
Inositol-phosphate phosphatase (2,353 words) [view diff] exact match in snippet view article find links to article
inhibition and modulation. There are at least 2 known steps in the de novo synthesis of myo-inositol from glucose 6-phosphate. In the first step, glucose
Amrubicin (288 words) [view diff] exact match in snippet view article find links to article
cancer. Amrubicin was the first anthracycline derivative created by de novo synthesis and was first published in 1989 by scientists from Sumitomo. Ueoka
AIR synthetase (FGAM cyclase) (578 words) [view diff] exact match in snippet view article
cyclo-ligase (AIR synthetase) is the fifth enzyme (EC 6.3.3.1) in the de novo synthesis of purine nucleotides. It catalyzes the reaction to form 5-aminoimidazole
GMP synthase (1,271 words) [view diff] exact match in snippet view article find links to article
converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which
6-Diazo-5-oxo-L-norleucine (987 words) [view diff] no match in snippet view article find links to article
(CAD) Pyrimidine-De-Novo-Synthesis CTP synthase (CTPS) Pyrimidine-De-Novo-Synthesis FGAR amidotransferase Purine-De-Novo-Synthesis Guanosine monophosphate
CAD protein (1,156 words) [view diff] no match in snippet view article find links to article
enzyme involved in the first three steps of pyrimidine biosynthesis. De-novo synthesis starts with cytosolic carbamoylphosphate synthetase II which uses
Triacsin C (448 words) [view diff] exact match in snippet view article find links to article
(lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering
Stearoyl-CoA 9-desaturase (3,134 words) [view diff] no match in snippet view article find links to article
single double bond between the C9 and C10 of long-chain acyl-CoAs from de-novo synthesis. This enzyme belongs to the family of oxidoreductases, specifically
Sphingosine kinase (627 words) [view diff] exact match in snippet view article find links to article
commonly referred to as a long-chain base (LCB), which is N-acylated. De novo synthesis of LCBs begins with the condensation of palmitoyl-CoA with serine
Phosphatidic acid phosphatase 2c (499 words) [view diff] exact match in snippet view article find links to article
PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction
Naegleria gruberi (521 words) [view diff] exact match in snippet view article find links to article
cytoskeleton, including flagella. This "transformation" includes de novo synthesis of basal bodies (or centrioles). It was first characterized in 1899
Dihydroorotate dehydrogenase (quinone) (677 words) [view diff] exact match in snippet view article
DHOQOs is both part of the electron transport chain and the pyrimidine de novo synthesis, it has been explored as a possible target for cancer treatment, immunological
Pfl RNA motif (635 words) [view diff] exact match in snippet view article find links to article
purH, which catalyzes the formylation of the intermediate AICAR in de novo synthesis of purines. The formyl group is taken from formyltetrahydrofolate
Undecaprenyl phosphate (1,151 words) [view diff] exact match in snippet view article find links to article
undecaprenyl phosphate. This type of synthesis is referred to as de novo synthesis where a complex molecule is created from simpler molecules as opposed
Phosphatidic acid (3,086 words) [view diff] exact match in snippet view article find links to article
bonded to carbon-2, and a phosphate group bonded to carbon-3. Besides de novo synthesis, PA can be formed in three ways: By phospholipase D (PLD), via the
Leflunomide (1,877 words) [view diff] exact match in snippet view article find links to article
dihydroorotate dehydrogenase (DHODH), which plays a key role in the de novo synthesis of uridine monophosphate (rUMP), which is required for the synthesis
Ribose 5-phosphate (1,491 words) [view diff] exact match in snippet view article find links to article
PRPP is essential for both the de novo synthesis of purines and for the purine salvage pathway. The de novo synthesis pathway begins with the activation
Tumor metabolome (2,576 words) [view diff] exact match in snippet view article find links to article
and phospholipid synthesis, a high rate of pyrimidine and purine de novo synthesis, a low ratio of Adenosine triphosphate and Guanosine triphosphate
Aminocoumarin (670 words) [view diff] exact match in snippet view article find links to article
from genetic mutation in the gyrB subunit. Other mechanisms include de novo synthesis of a coumarin-resistant gyrase B subunit by the novobiocin producer
Lirentelimab (458 words) [view diff] exact match in snippet view article find links to article
Lirentelimab inhibits mast cells' IgE-mediated degranulation and de novo synthesis of prostaglandin D2 in vitro. Mild-to-moderate infusion reactions
David Bennett (neurologist) (576 words) [view diff] exact match in snippet view article
"in recognition of methods he developed with colleagues to measure de novo synthesis of amyloid-beta (Abeta)." Bennett is the principal investigator of
George Stark (2,378 words) [view diff] exact match in snippet view article find links to article
transcarbamylase is one of the first three enzymes necessary for de novo synthesis of pyrimidine nucleotides, and after Stark was able to isolate this
Barbara Illingworth Brown (1,156 words) [view diff] case mismatch in snippet view article find links to article
Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy
RB-120 (304 words) [view diff] exact match in snippet view article find links to article
mediated response and production of second messenger, without need for de novo synthesis of any neurotransmitters. Noble F, Smadja C, Valverde O, Maldonado
Phosphatase (1,483 words) [view diff] exact match in snippet view article find links to article
Reichard, P (1986). "Interrelations between substrate cycles and de novo synthesis of pyrimidine deoxyribonucleoside triphosphates in 3T6 cells". Proceedings
Methanesulfonyl fluoride (1,020 words) [view diff] exact match in snippet view article find links to article
inhibitor of AChE and its inhibition of AChE is only overcome by de novo synthesis of new AChE in each tissue. The recovery of AChE activity in the brain
Formylation (2,827 words) [view diff] exact match in snippet view article find links to article
aminopeptidase. Two formylation reactions are required in the eleven step de novo synthesis of inosine monophosphate (IMP), the precursor of the purine ribonucleotides
Glycerol 3-phosphate (645 words) [view diff] exact match in snippet view article find links to article
kinase. + ATP → + ADP Glycerol 3-phosphate is a starting material for de novo synthesis of glycerolipids. In eukaryotes, it is first acylated on its sn-1
Pyridoxine 5'-phosphate synthase (1,259 words) [view diff] exact match in snippet view article find links to article
Garrido-Franco M (April 2003). "Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond". Biochimica et Biophysica Acta. 1647 (1–2):
Capecitabine (1,103 words) [view diff] exact match in snippet view article find links to article
monophosphate (ThMP), the active form of thymidine which is required for the de novo synthesis of DNA. One of the brand names is Xeloda, marketed by Genentech. Others
Sphingomyelin (1,964 words) [view diff] exact match in snippet view article find links to article
Sphingomyelin de novo synthesis pathway
Ornithine decarboxylase (2,082 words) [view diff] exact match in snippet view article find links to article
Kang S, Wang T, Gnanaprakasam JR, Yao Y, et al. (December 2020). "De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and
Library (biology) (1,204 words) [view diff] exact match in snippet view article
Alternatively, mutations can be targeted to specific codons during de novo synthesis or saturation mutagenesis to construct one or more point mutants of
Glycerol 1-phosphate (358 words) [view diff] exact match in snippet view article find links to article
+ H+ → + NAD(P)+ Glycerol 1-phosphate is a starting material for de novo synthesis of ether lipids, such as those derived from archaeol and caldarchaeol
DNA synthesis (1,799 words) [view diff] exact match in snippet view article find links to article
quickly from DNA through next generation sequencing technologies, de novo synthesis of DNA is a major bottleneck in the process. Only one nucleotide can
NAPQI (725 words) [view diff] exact match in snippet view article find links to article
administration)), which is processed by cells to L-cysteine and used in the de novo synthesis of GSH. Cytochrome P450 oxidase Liver failure Centrilobular necrosis
FNR regulon (1,423 words) [view diff] exact match in snippet view article find links to article
FNR in vivo. The formation of [4Fe–4S] FNR from apoFNR is part of de novo synthesis of active FNR. The reaction requires cysteine desulphurase which catalyzes
1-Deoxysphingolipids (2,298 words) [view diff] exact match in snippet view article find links to article
are toxic. 1-DeoxySLs has a similar pattern to sphingolipids during de novo synthesis. The reaction is catalyzed by the enzyme serine palmitoyltransferase
Nicotinamide riboside (1,803 words) [view diff] exact match in snippet view article find links to article
group and are referred to as ‘amidated’ pathways. The pathways for de novo synthesis from tryptophan and from NA salvage are ‘deamidated’ pathways, which
Pyrobaculum (1,162 words) [view diff] exact match in snippet view article find links to article
reduction of sulfur and arsenic, were identified. Pathways for the de novo synthesis of nearly all required cofactors and metabolites were identified.
PPAP2A (864 words) [view diff] exact match in snippet view article find links to article
PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction
Lipid signaling (5,635 words) [view diff] exact match in snippet view article find links to article
Chemotherapeutic agents such as daunorubicin and etoposide enhance the de novo synthesis of ceramide in studies done on mammalian cells. The same results were
Chaperone-mediated autophagy (3,623 words) [view diff] exact match in snippet view article find links to article
controlling the degradation rates of LAMP-2A monomers in lysosomes and by de novo synthesis of LAMP-2A molecules. In addition, transport of substrates also depends
Glutaminolysis (1,487 words) [view diff] exact match in snippet view article find links to article
infiltrated in the citric acid cycle is low and acetyl-CoA is available for de novo synthesis of fatty acids and cholesterol. The fatty acids can be used for phospholipid
Microbial cyst (2,512 words) [view diff] exact match in snippet view article find links to article
while others maintain kinetosomes and/or microtubular structures. De novo synthesis of cyst wall precursors in the endoplasmic reticulum also frequently
Α-Linolenic acid (2,124 words) [view diff] exact match in snippet view article find links to article
because the absence of the required 12- and 15-desaturase enzymes makes de novo synthesis from stearic acid impossible. Eicosapentaenoic acid (EPA; 20:5, n−3)
Aziridines (1,684 words) [view diff] case mismatch in snippet view article find links to article
Mita; Nobuhisa Fukuda; Motomu Kanai; Masakatsu Shibasaki (2006). "De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso-Aziridines
Sphingomonas yanoikuyae (889 words) [view diff] case mismatch in snippet view article find links to article
Stallforth, Pierre; Adibekian, Alexander; Seeberger, Peter H. (2008). "De Novo Synthesis of ad-Galacturonic Acid Thioglycoside as Key to the Total Synthesis
CDP-choline pathway (932 words) [view diff] exact match in snippet view article find links to article
restricted. Gibellini F, Smith TK (Jun 2010). "The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine". IUBMB Life.
Dipalmitoylphosphatidylcholine (2,201 words) [view diff] exact match in snippet view article find links to article
PC is primarily present as dipalmitoylphosphatidylcholine (DPPC). De novo synthesis of phosphatidylcholine in the lung arises primarily from cytidine
Galiella rufa (1,549 words) [view diff] exact match in snippet view article find links to article
regulating substances – introduction of the gibberellic acid-induced de novo synthesis of hydrolytic enzymes in embryoless seeds of Triticum aestivum as
Eliezer E. Goldschmidt (885 words) [view diff] exact match in snippet view article find links to article
Trebitsh, T; Goldschmidt, EE; Riov, J (1993). "Ethylene induces de novo synthesis of chlorophyllase, a chlorophyll degrading enzyme, in citrus fruit
Bromantane (3,194 words) [view diff] exact match in snippet view article find links to article
activity and psychostimulant effects of bromantane is activation of the de novo synthesis of dopamine via modulation of gene expression. A selection of quoted
Terminal deoxynucleotidyl transferase (3,518 words) [view diff] case mismatch in snippet view article find links to article
tumors of childhood. TdT has also seen recent application in the De Novo synthesis of oligonucleotides, with TdT-dNTP tethered analogs capable of primer
Inverse electron-demand Diels–Alder reaction (2,643 words) [view diff] exact match in snippet view article find links to article
053. Boger, Dale L.; Robarge, Kirk D. (1 November 1988). "Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder
Phosphatidate phosphatase (1,617 words) [view diff] exact match in snippet view article find links to article
only to phosphatidate. There are speculated to be involved in the de novo synthesis of glycerolipids. Each of the 3 Lipin proteins found in mammals—Lipin1
Fructolysis (1,948 words) [view diff] exact match in snippet view article find links to article
Krebs cycle, is converted to citrate and subsequently directed toward de novo synthesis of the free fatty acid palmitate. The first step in the metabolism
IMPDH1 (1,110 words) [view diff] exact match in snippet view article find links to article
inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in the IMPDH1 gene are a cause of
UCK2 (2,398 words) [view diff] exact match in snippet view article find links to article
and DNA. Pyrimidine biosynthesis can occur through two pathways: de novo synthesis, which relies on L-glutamine as the pathway precursor, and salvage
Seth Lederman (1,317 words) [view diff] case mismatch in snippet view article find links to article
and Lena H. Sun, July 6, 2017". Koblentz, Gregory D. (2017). "The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations
GDP-mannose 4,6-dehydratase (974 words) [view diff] exact match in snippet view article find links to article
GDP-mannose 4,6-hydro-lyase. The enzyme is a part of the GDP-Fucose de novo synthesis pathway and catalyzes the first step in the process that gives us
Creatine (6,539 words) [view diff] exact match in snippet view article find links to article
total body pool, the lost creatine must be replaced from diet or de novo synthesis. Cannan RK, Shore A (1928). "The creatine-creatinine equilibrium.
Ribozyme (5,181 words) [view diff] exact match in snippet view article find links to article
PMID 15189159. Ikawa Y, Tsuda K, Matsumura S, Inoue T (September 2004). "De novo synthesis and development of an RNA enzyme". Proceedings of the National Academy
Oncostatin M (4,317 words) [view diff] exact match in snippet view article find links to article
function of OSM. Like many cytokines OSM is produced from cells by de novo synthesis followed by release through the classical secretion pathway. However
Methylotroph (3,391 words) [view diff] exact match in snippet view article find links to article
is the assimilation of single carbon units into biomass. Through de novo synthesis, methylotrophs must form carbon-carbon bonds between 1-Carbon (C1{\displaystyle
Dihydrofolate reductase (4,581 words) [view diff] exact match in snippet view article find links to article
dihydrofolate into tetrahydrofolate, a proton shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional
Campylobacter jejuni (4,968 words) [view diff] exact match in snippet view article find links to article
of the other amino acids which helps to lower the anabolic cost of de novo synthesis. If other sources of carbon are exhausted, C. jejuni can also utilize
Oseltamivir total synthesis (2,309 words) [view diff] case mismatch in snippet view article find links to article
1021/ja0616433. PMID 16683783. S2CID 20852603. Fukuta, Yuhei (2006). "De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso -Aziridines
Chlorophyllase (1,512 words) [view diff] exact match in snippet view article find links to article
Trebitsh T, Goldschmidt EE, Riov J (October 1993). "Ethylene induces de novo synthesis of chlorophyllase, a chlorophyll degrading enzyme, in Citrus fruit
Oroidin (1,330 words) [view diff] case mismatch in snippet view article find links to article
Wang, Yong-Gang; Romo, Daniel; Molinski, Tadeusz F. (2012-04-27). "De Novo Synthesis of Benzosceptrin C and Nagelamide H from 7- 15 N-Oroidin: Implications
Labyrinthula (1,989 words) [view diff] exact match in snippet view article find links to article
mostly by mitosis. Some features of their binary fission are the de novo synthesis of the bothrosome and the cytokinesis, that occurs by vesicle accumulation
Interleukin-1 family (6,005 words) [view diff] exact match in snippet view article find links to article
macrophages do not contain preformed IL-1α precursors, but instead rely on de novo synthesis. The IL-1α precursor is processed to its mature 17-kDa form by a Ca2+-activated
Cholesterol (8,457 words) [view diff] exact match in snippet view article find links to article
Rather, astrocytes produce and distribute cholesterol in the brain. De novo synthesis, both in astrocytes and hepatocytes, occurs by a complex 37-step process
Lesch–Nyhan syndrome (4,739 words) [view diff] exact match in snippet view article find links to article
essential synthesis steps. Genetic mutations affecting the enzymes of the de novo synthesis pathway may possibly contribute to the disease, although these are
Herpes (8,735 words) [view diff] exact match in snippet view article find links to article
Richard L.; Preston, Chris M.; Sawtell, Nancy M. (2009-03-01). "De novo synthesis of VP16 coordinates the exit from HSV latency in vivo". PLOS Pathogens
Holocentric chromosome (4,774 words) [view diff] exact match in snippet view article find links to article
expression of the telomerase coding gene so that they can initiate a de novo synthesis of telomere sequences at internal breakpoints, resulting in the stabilization
Symbiodinium (7,408 words) [view diff] exact match in snippet view article find links to article
Tadashi; Badger, Murray (2008). "Heat stress causes inhibition of the de novo synthesis of antenna proteins and photobleaching in cultured Symbiodinium".
1-Lysophosphatidylcholine (2,167 words) [view diff] no match in snippet view article find links to article
phosphatidylcholine containing specific fatty acids, but are not used for the de-novo synthesis of phosphatidylcholine. In contrast to these finding from rat liver
Incineration (9,417 words) [view diff] exact match in snippet view article find links to article
destroyed by combustion, their reformation by a process known as 'de novo synthesis' as the emission gases cool is a probable source of the dioxins measured
Mycoplasma laboratorium (3,641 words) [view diff] exact match in snippet view article find links to article
problematic and virtually precludes the possibility of performing a de novo synthesis of 'M. laboratorium', the origin of the attention in the popular press
Discovery and development of proton pump inhibitors (4,718 words) [view diff] exact match in snippet view article find links to article
inactive pumps after the drug has been eliminated from the blood, and de novo synthesis of new pumps. Although the drugs omeprazole, lansoprazole, pantoprazole
GNMT (3,150 words) [view diff] exact match in snippet view article find links to article
inhibitor of this enzyme. Thus, GNMT has been proposed to link the de novo synthesis of methyl groups to the ratio of SAM to SAH, which in turn serves
Discovery and development of cyclooxygenase 2 inhibitors (4,463 words) [view diff] exact match in snippet view article find links to article
generate prostaglandins. It was demonstrated that the increase is due to de novo synthesis of fresh enzyme. In 1991, during the investigation of the expression
Thymidine kinase (11,106 words) [view diff] exact match in snippet view article find links to article
that inhibit the enzyme dihydrofolate reductase thus blocking the de novo synthesis of thymidine monophosphate. One such medium that is commonly used
Algae fuel (11,928 words) [view diff] exact match in snippet view article find links to article
to the initial culture, indicating that the algal cells utilized de novo synthesis of fatty acids. It is vital for the lipid content in algal cells to
Β-Hydroxy β-methylbutyric acid (9,978 words) [view diff] exact match in snippet view article find links to article
the cell membrane, and sarcolemma is the one that relies mainly on de novo synthesis of cholesterol. This is important under stressful conditions when
Vassilios Papadopoulos (2,436 words) [view diff] case mismatch in snippet view article find links to article
Enrico; Wabitsch, Martin; Papadopoulos, Vassilios (January 2014). "De Novo Synthesis of Steroids and Oxysterols in Adipocytes". Journal of Biological Chemistry
Glossary of cellular and molecular biology (M–Z) (19,756 words) [view diff] exact match in snippet view article
from commercial suppliers which create oligonucleotides on demand by de novo synthesis. primer dimer (PD) primer walking priming The initiation of nucleic
Nicolas Bazan (4,361 words) [view diff] exact match in snippet view article find links to article
that this fatty acid is introduced to a large extent through the de novo synthesis of phosphatidic acid. His laboratory later identified an activating
Thymidine kinase in clinical chemistry (9,988 words) [view diff] exact match in snippet view article find links to article
pathways unrelated to thymidine, by the enzyme thymidylate synthase (De novo synthesis). This second route is used by the cell under normal conditions, and