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Longer titles found: Dihydrofolate reductase deficiency (view), Dihydrofolate reductase inhibitor (view)

searching for Dihydrofolate reductase 41 found (388 total)

Trimethoprim/polymyxin (45 words) [view diff] no match in snippet view article find links to article

The drug combination trimethoprim/polymyxin (INNs, trade name Polytrim) is an antimicrobial solution for topical ophthalmic use in the treatment of acute

Dihydropteroate (133 words) [view diff] exact match in snippet view article find links to article

dihydropteroate synthetase inhibition is comparable to that of dihydrofolate reductase inhibition by trimethoprim, another bacteriostatic agent. Combinations

4-Aminosalicylic acid (1,800 words) [view diff] exact match in snippet view article find links to article

dihydrofolate at the binding site of dihydrofolate reductase (DHFR). The binding of Hydroxy-H2PteGlu to dihydrofolate reductase will block the enzymatic activity

Beta bulge (692 words) [view diff] case mismatch in snippet view article find links to article

They are also of functional importance in the proteins DHFR (Dihydrofolate Reductase) and SOD (Superoxide Dismutase), where loops containing bulges

Bruce Donald (1,291 words) [view diff] exact match in snippet view article find links to article

symmetry, was used in the structure determination of the enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Cryptosporidium hominis, an

REPIN1 (1,190 words) [view diff] exact match in snippet view article find links to article

originally was first identified in a study focusing on replication of dihydrofolate reductase gene (dhfr) in Chinese hamsters, with it initiating near stable

Mir-24 microRNA precursor family (578 words) [view diff] exact match in snippet view article find links to article

(August 2007). "A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance". Proceedings of the National

Ross D. King (1,518 words) [view diff] exact match in snippet view article find links to article

structure-activity relationships of trimethoprim analogues binding to dihydrofolate reductase". Proceedings of the National Academy of Sciences of the United

Neural tube defect (5,814 words) [view diff] exact match in snippet view article find links to article

though at least one study have shown slow and variable activity of dihydrofolate reductase in human liver. A diet rich in natural folate (350 μg/d) can show

Sugauli, Bihar (798 words) [view diff] exact match in snippet view article find links to article

Gleisner, J. M.; Blakley, R. L. (2 December 1975). "Bovine liver dihydrofolate reductase: purification and properties of the enzyme". Biochemistry. 14 (24):

NAD+ kinase (1,452 words) [view diff] exact match in snippet view article find links to article

Johnson-Farley N, Bertino JR, Abali EE (Feb 2013). "Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs". Molecular

Bacardi (3,778 words) [view diff] exact match in snippet view article find links to article

Gleisner, J. M.; Blakley, R. L. (2 December 1975). "Bovine liver dihydrofolate reductase: purification and properties of the enzyme". Biochemistry. 14 (24):

Vitamer (1,244 words) [view diff] exact match in snippet view article find links to article

to tetrahydrofolate, a second biologically active vitamer, by dihydrofolate reductase. The liver has a limited capacity to metabolize folic acid into

Vitamer (1,244 words) [view diff] exact match in snippet view article find links to article

to tetrahydrofolate, a second biologically active vitamer, by dihydrofolate reductase. The liver has a limited capacity to metabolize folic acid into

Dan T. Major (807 words) [view diff] case mismatch in snippet view article find links to article

Mechanics Simulations: A Case Study of the Hydride Transfer in Dihydrofolate Reductase". Journal of Chemical Theory and Computation. 8 (7): 2484–2496

Y. D. Sharma (professor) (1,243 words) [view diff] exact match in snippet view article

heterozygosity at four microsatellite loci flanking Plasmodium vivax dihydrofolate reductase gene". Molecular and Biochemical Parasitology. 153 (2): 178–185

Gordon Hammes (993 words) [view diff] case mismatch in snippet view article find links to article

Catalysis: Single-Molecule and Transient Kinetics Investigation of Dihydrofolate Reductase". Biochemistry. 44 (51): 16835–16843. doi:10.1021/bi051378i. PMID 16363797

Gordon Hammes (993 words) [view diff] case mismatch in snippet view article find links to article

Catalysis: Single-Molecule and Transient Kinetics Investigation of Dihydrofolate Reductase". Biochemistry. 44 (51): 16835–16843. doi:10.1021/bi051378i. PMID 16363797

ACTG2 (1,017 words) [view diff] case mismatch in snippet view article find links to article

Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes". Mol. Cell. Biol. 23 (6): 1961–7. doi:10.1128/MCB

Degron (1,521 words) [view diff] exact match in snippet view article find links to article

of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis". The Journal of Biological Chemistry

Cauliflower mosaic virus (2,796 words) [view diff] exact match in snippet view article find links to article

seriously limit the size of DNA insert clonable in CaMV. The bacterial dihydrofolate reductase DHFR gene has been successfully cloned into the CaMV genome, in

Protein dynamics (2,549 words) [view diff] exact match in snippet view article find links to article

dynamics are important for function, e.g. enzyme catalysis in dihydrofolate reductase (DHFR), yet they are also posited to facilitate the acquisition

Sarcocystis neurona (1,642 words) [view diff] exact match in snippet view article find links to article

been recognized and confirmed. Treatment has been confined to dihydrofolate reductase inhibitors including sulfonamides and pyrimethamine over the years

Photopharmacology (3,790 words) [view diff] exact match in snippet view article find links to article

azobenzene is phototrexate. Phototrexate is an inhibitor of human dihydrofolate reductase and is an analogue of methotrexate, a chemotherapy agent. When

Hit selection (1,707 words) [view diff] exact match in snippet view article find links to article

Cleary MA (2010). "A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling". PLOS ONE

OLIG2 (3,206 words) [view diff] exact match in snippet view article find links to article

"1H nuclear magnetic resonance studies of Lactobacillus casei dihydrofolate reductase: effects of substrate and inhibitor binding on the histidine residues"

Gary B. Fogel (1,845 words) [view diff] exact match in snippet view article find links to article

Jonathan; Fogel, Gary B. (October 2011). "Structural-based analysis of dihydrofolate reductase evolution". Molecular Phylogenetics and Evolution. 61 (1): 212–230

Carol Fierke (645 words) [view diff] exact match in snippet view article find links to article

"Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli". Biochemistry. 26 (13): 4085–4092. doi:10

Retrometabolic drug design (2,829 words) [view diff] exact match in snippet view article find links to article

agents, soft angiotensin converting enzyme (ACE) inhibitors, soft dihydrofolate reductase (DHFR) inhibitors, soft cancineurin inhibitors (soft immunosuppressants)

Sarcocystis (4,452 words) [view diff] exact match in snippet view article find links to article

experimentally infected sheep. In horses, treatment has been confined to dihydrofolate reductase inhibitors such as the sulfonamides and pyrimethamine. Sulfadiazine

Theophylline (2,290 words) [view diff] case mismatch in snippet view article find links to article

Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors". Archiv der Pharmazie. 349 (8): 602–613. doi:10.1002/ardp

Myc (6,672 words) [view diff] exact match in snippet view article find links to article

Corcos D (August 1991). "Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc". Oncogene. 6 (8): 1453–7. PMID 1886715

Mass drug administration (5,313 words) [view diff] no match in snippet view article find links to article

"In vitro selection of Plasmodium falciparum lines resistant to dihydrofolate-reductase inhibitors and cross resistance studies". Jpn. J. Med. Sci. Biol

Strictly standardized mean difference (3,541 words) [view diff] exact match in snippet view article find links to article

Bereswill S (ed.). "A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling". PLOS ONE

Interface force field (2,760 words) [view diff] exact match in snippet view article find links to article

and energetics of ligand binding to proteins:Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system". Proteins: Structure, Function

Thymidine kinase (11,263 words) [view diff] exact match in snippet view article find links to article

medium with methotrexate or aminopterin that inhibit the enzyme dihydrofolate reductase thus blocking the de novo synthesis of thymidine monophosphate

Force field (chemistry) (9,925 words) [view diff] exact match in snippet view article

and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system". Proteins. 4 (1): 31–47.

Origin of replication (12,561 words) [view diff] exact match in snippet view article find links to article

regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone". Nucleic Acids Research. 39 (8): 3141–55. doi:10

Somatic evolution in cancer (9,913 words) [view diff] exact match in snippet view article find links to article

resistance came from studies of methotrexate. Methotrexate inhibits the dihydrofolate reductase (DHFR) gene. However, methotrexate therapy appears to select for

Intracellular delivery (8,788 words) [view diff] exact match in snippet view article find links to article

"Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase". Nature. 275 (5681): 617–624. Bibcode:1978Natur.275..617C. doi:10

Treatment of lung cancer (6,590 words) [view diff] exact match in snippet view article find links to article

as an antimetabolite. Pemetrexed inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. Pemetrexed induces