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alternate case: conformational change

Lactose synthase (488 words) [view diff] exact match in snippet view article find links to article

events to occur, meaning the conformational change needs to occur after the binding of the substrate. If the conformational change is induced before the binding

the 50S subunit joins, it hydrolyzes GTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome

molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell

activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen

flippases undergo conformational change from E1 to E2 (E1 and E2 stand for different conformations of flippases). Further conformational change is induced by

GDP/GTP structural cycles of human Arf1 and Arf6 feature a unique conformational change that affects the beta2beta3 strands connecting switch 1 and switch

the acetyl-CoA. Only when this citryl-CoA has formed will another conformational change cause thioester hydrolysis and release coenzyme A. This ensures

relationship, but binding induces a conformational change and activates the receptor. This conformational change is often the result of small changes

There is evidence that upon ligand binding at the α subunit, a conformational change occurs in the β subunit that allows it to additionally bind to IL-10

plentiful in the cell, it binds to the protein, which causes a conformational change in the protein. The repressor complex then binds to its operator

structures: no amount of re-orientation of a molecule as a whole or conformational change converts one chemical into its enantiomer. Chemical structures with

embedded 11-cis-retinal, whose light excitation causes a cis-trans conformational change that begins the process of chemical signalling to the brain. It

found between the two. Lymphotactins can go through a reversible conformational change which changes its binding shifts. In normal tissues, XCL1 is found

of SERDs involves binding to the estrogen receptor, leading to a conformational change that facilitates recruitment of cellular machinery to degrade the

their respective chaperones which then allows them undergo a large conformational change that allows them to either bind to their substrates with higher

recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed

an intermediate plasminogen structure suggests that plasminogen conformational change to the open form is initiated through KR-5 transiently peeling away

binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55

predominantly leucine in the d position of the heptad repeat. A conformational change in a heptad repeat in the SARS-CoV-2 spike protein facilitates entry

NADPH binds, followed by the substrate. Binding of NADPH induces a conformational change (Enzyme•NADPH → Enzyme*•NADPH) that involves hinge-like movement

ATP7A, also known as Menkes' protein (MNK), is a copper-transporting P-type ATPase which uses the energy arising from ATP hydrolysis to transport Cu(I)

catalysts to dephosphorylate the light-chains on myosin, which causes a conformational change in the myosin and relaxes the muscle. The enzyme is highly conserved

transducin activated. Transducin is activated by metarhodopsin II, a conformational change in rhodopsin caused by the absorption of a photon by the rhodopsin

travel to the brain. The light causes a conformational change in a protein called rhodopsin. This conformational change sets in motion a series of molecular

serine side chain to twist, causing a conformational change in the second subunit. This conformational change also causes the serine to no longer be

that protein misfolding of GALT, which may lead to an unfavorable conformational change that impacts its thermal stability and substrate-binding affinity

heparin stimulation of Factor IXa and Xa inhibition depends on a conformational change within antithrombin involving the reactive site loop and is thus

protein which is accessible from the periplasm. On binding, a large conformational change takes place which makes the sugar binding site accessible from the

symported Na+. After ion and substrate binding have taken place, some conformational change must occur. From the conformational differences between the structure

the associated electric field induces a conformational change in the potassium channel. The conformational change distorts the shape of the channel proteins

modification of glutamyl (Glu) residues. These Gla residues induce a conformational change from a 3 10 helix to an alpha helix on binding to Calcium. In the

activator protein, causing a conformational change in the DNA-binding domain of the activator. This conformational change "turns on" the activator by allowing

At this site acetylation or methylation can take place causing a conformational change to the chromatin. At the active chromatin sequence site deacetylation

role in the enzyme's catalytic activity. Studies have shown that conformational change of this loop region from the open conformation to the closed conformation

At this site acetylation or methylation can take place causing a conformational change to the chromatin. At the active chromatin sequence site deacetylation

protein. RydC is known to bind the Hfq protein, which causes a conformational change in the RNA molecule. The Hfq/RydC complex is then thought to bind

have two conformational states. The binding of the ligand causes conformational change in the other subunits of the multimeric protein. Although the subunits

of coal combustion. Magnesium acetate has been found to cause a conformational change in Escherichia coli enzyme Primase. In this experiment Mg(OAc)2

IV is important for translocation, as it undergoes a significant conformational change and enters the A site on the 30S ribosomal subunit, pushing the

hydrophobic residues. Upon binding, the receptor often undergoes a conformational change and may bind further, signaling ligands to activate a signaling

into an all-trans form. In the retina, this conversion induces a conformational change in the surrounding opsin protein pigment, leading to signaling through

allosterically activated by the magnesium/ATP complex, associated with a conformational change upon nucleotide binding that depends upon interactions with Q89

a conformational change, bringing the two JAKs close enough to phosphorylate each other. The JAK autophosphorylation induces a conformational change within

If these receptors are ligand-gated ion channels, a resulting conformational change opens the ion channels, which leads to a flow of ions across the

hormones. When a GPCR is activated by its extracellular ligand, a conformational change is induced in the receptor that is transmitted to an attached intracellular

and inorganic phosphate (Pi) is released. This step also causes a conformational change in the enzyme that promotes the release of GDP. GDP is involved

LFA-1. This induces an intermediate extended conformation. The conformational change stimulates a recruitment of proteins to form an activation complex

mechanism remains unknown, it is expected to work by forcing a conformational change in the pore domain of the channel. This part of the channel is expected

revealed that the asymmetric binding of Go-protein to GPR156 triggers conformational change of its cytoplasmic face without altering dimer interface.  Although

residues interact with L-ornithine. The binding of CP induces a global conformational change, while the binding of L-ornithine only induces movement of the SMG

thylakoid membrane). The breakdown of the proton gradient leads to conformational change in CF1—providing enough energy in the process to convert ADP to

particular molecule under study. In particular, rare events such as conformational change, which are masked in an ensemble, may be observed. There are many

the all-trans-retinal configuration. Opsin therefore undergoes a conformational change to metarhodopsin II. Metarhodopsin II activates a G protein known

hydrophobic pockets of the NHR core that is formed following the conformational change in gp41 that creates the six-helix bundle. These pockets could potentially

chemokine is SDF-1. Following SDF-1 binding, the integrin undergoes a conformational change of the alpha and beta domains that is necessary to confer high binding

the surface of the target cell. Upon binding, gp120 undergoes a conformational change, which causes the formation of the coreceptor binding site on gp120

specificity for its target DNA sequence. Binding of the enzyme induces a conformational change in the DNA, bending it by about 50°. DNA bending results in the

was the first to propose that protein denaturation was a purely conformational change, i.e., corresponded to protein unfolding and not to some chemical

significant since it explained that rather than the ligand inducing a conformational change (as in induced fit), the ligand can select a preexisting (relatively

purine ligands via a natural aptamer domain. This binding causes a conformational change in the mRNA that can affect translation by revealing an expression

Testin (also known as TESS) is a protein that in humans is encoded by the TES gene located on chromosome 7. TES is a 47 kDa protein composed of 421 amino

initiates a conformational change of the AAA domain ring into the “closed” configuration, movement of the buttress, and a conformational change in the linker

highly polar ones. Binding of the NADPH coenzyme causes a massive conformational change, reorienting a loop, effectively locking the coenzyme in place.

protein types including phosphatases, ion channels, and kinases. This conformational change is associated with undergoing various cellular processes: including

chains to the adenine and ribose rings of the nucleotide. This conformational change shifts DnaK from a closed to an open conformation and allows the

protein types including phosphatases, ion channels, and kinases. This conformational change is associated with undergoing various cellular processes: including

of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated

structure is formed, katanin hydrolyzes ATP, and likely undergoes a conformational change that puts mechanical strain on the tubulin subunits, which destabilizes

leads to create a dimer between procaspases, which generates a conformational change. This dimerization is essential to create the active site; a p12

and dnaC form dimers with six dnaC polypeptides. This is due to a conformational change of dnaC. These dimers a specific structure, containing a small lobe

than in the E. coli variety, so it is likely that a much smaller conformational change is necessary for catalysis. The ATP binding domain of argininosuccinate

protein, activation of a ribozyme, release of silencing RNA (siRNA), conformational change, and/or binding other nucleic acids. Riboregulators contain two

receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of

excitatory neurotransmitter, binds to the Gria2 resulting in a conformational change. This leads to the opening of the channel converting the chemical

accomplished by TCR binding is still debated. Mechanisms involving conformational change of TCR, TCR aggregation and kinetic segregation have been suggested

the alpha-1 subunits bind glycine and undergo a conformational change, inducing a conformational change in the pentamer, causing the ion-channel to open

verification] As AMP binds both Bateman domains the γ subunit undergoes a conformational change which exposes the catalytic domain found on the α subunit. It is

products. Activation refers to the opening of ion channels, i.e. the conformational change that allows ions to pass. "The Activation Energy of Chemical Reactions"

50S ribosome subunit. The type A streptogramin binding causes a conformational change to the 50S subunit, which increases the activity of the type B streptogramin

anchors. When an agonistic ligand binds to the opioid receptor, a conformational change occurs, and the GDP molecule is released from the Gα sub-unit. This

their putative DAMP or PAMP ligands. These receptors undergo a conformational change, exposing their PYD. Generally, an adaptor protein (ASC) containing

to one of the four heme groups, the protein undergoes a drastic conformational change that sharply increases the oxygen affinity of the other three subunits

These regulatory elements bind small molecules which results in a conformational change within the 5’UTR of the mRNA. The changes in the mRNA secondary

must bind to each of the calmodulins to induce the co-operative conformational change that opens the gate, which explains why this process has a Hill

mechanism from the B-DNA configuration to the Z-DNA configuration. The conformational change from B-DNA to the Z-DNA structure was unknown at the atomic level

binding to the extracellular part of the receptor induces a rotation (conformational change) of part of the receptor's transmembrane helices. The rotation alters

mechanisms.[citation needed] Some allosteric modulators induce a conformational change in their target receptor which increases the binding affinity and/or

ligand can bind to a protomer in either conformation. Only the conformational change alters the affinity of a protomer for the ligand. The regulators

turnover by MAPK8-dependent phosphorylation of ITCH and a subsequent conformational change in ITCH. This mechanism is discrete from the direct activation of

becomes inactive. However, when C3b undergoes its post-cleavage conformational change, a binding site for a plasma protein called Factor B is also exposed

The exercise brought into focus the necessity of accommodating conformational change and the difficulty of discriminating between conformers. It also

ATPase during the transport cycle. This phosphate transfer powers a conformational change in the enzyme that helps drive ion transport.[citation needed] The

before and after the reaction. It has been suggested that this conformational change occurs following phosphorylation, with the negatively charged Asp-62

the loop that connects the adjacent EF-hand motifs and causes a conformational change in the EF-hand motif so it interacts with the pore to cause quick

the bromodomain containing protein BRD4. This release leads to a conformational change in 7SK RNA and the ejection of HEXIM. hnRNPs stabilize the complex

phosphorylase, the less active "b" form can itself be activated without the conformational change. 5'AMP acts as an allosteric activator, whereas ATP is an inhibitor

presence of cAMP, each R subunit binds 2 cAMP molecules and causes a conformational change in the R subunits that releases the C subunits to phosphorylate

regulatory domain. When tetracycline binds this cavity, it causes a conformational change that affects the DNA-binding domain so that TetR is no longer able

receptor antagonism, enzyme inhibition, or ion channel blockade. A conformational change in the target is induced by the stimulus which results in a change

active, a ligand must bind to the receptor and cause a conformational change. This conformational change causes the alpha subunit to dissociate from the complex

phosphate backbone of ssDNA. This interaction presumably causes a conformational change in the actively bound subunit, providing for the efficient release

NTP binding causes the RdRp to undergo a conformational change. Active site closure – the conformational change, initiated by the correct NTP binding, results

near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance. Kolodziejczyk R, Kochman M, Bujacz G,

mitochondrial matrix depending on the state. A substrate induced conformational change occurs when citrate enters from the matrix side and binds to the

orient the ß- and γ-phosphate groups. The NPL then undergoes a conformational change to form a hydrogen bond between Ser27 and the ß-phosphate group

As the endosomes acidify, LRP2 release its cargo and undergoes a conformational change which collapses the binding pockets to inhibit ligands rebinding

reductase—folate complex: Catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features, Biochemistry 34, 11037-11048

beta-barrel structures. The GTP-binding domain I undergoes a dramatic conformational change upon GTP hydrolysis to GDP, allowing EF-Tu to dissociate from aa-tRNA

important when some of the binding energy can be used to cause a conformational change in the receptor, resulting in altered behavior for example of an

disease-associated G5703A mutation in human mitochondrial DNA causes a conformational change and a marked decrease in steady-state levels of mitochondrial tRNA(Asn)"

neurotransmitters to a GPCR activates the receptor by causing a conformational change, which in turn activates the bound G protein on the intracellular-side

these ions also activate the remaining dimer of two A units via a conformational change. Factor XIIIa (dimer of two active A units) crosslinks fibrins within

The chemical energy from the phosphodiester bonds results in a conformational change which is transferred to other domains (especially the HWD and the

extracellular domain to the transmembrane regions, resulting in a conformational change of the ASIC to its open state. However, it remains fairly inconclusive

Mad2 requiring a novel, so far poorly understood, mechanism of conformational change. Mismatches in chromosome number (aneuploidies) during meiosis are

membranes, and this proves to be integral to the transmission of conformational change; secreted PrP lacking the anchor component is unaffected by the

sensors undergo a conformational change in response to calcium concentration spikes during neuronal firing; this conformational change modulates the conformation

"Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase

to the allosteric sites of nicotinic receptors, which causes a conformational change. This allosteric modulation increases the nicotinic receptor's response

activates voltage-gated sodium channel, which through a complex conformational change, allows more sodium ions to enter the neuron, leading to further

Once the neurotransmitter binds to the receptor, it will cause a conformational change that will allow ions to directly flow into the cell. The second

glutamate molecules, undergoes a conformational change that resembles the opening of a clam shell. This conformational change opens an ion channel within the

early events of elongation. The binding of streptogramin A causes a conformational change that increases the ribosomal binding activity of streptogramin B

at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change". Acta Crystallographica Section D. 54 (Pt 6 Pt 2): 1319–35. Bibcode:1998AcCrD

araC, araC binds with the arabinose and acts as an activator. This conformational change in the araC no longer can form a loop, and the linear gene segment

heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens". The Journal of Neuroscience. 24 (48):

that the presence of NAS causes CysB to undergo a conformational change. This conformational change allows CysB to bind properly to all the half sites

state and post cleavage state, it was determined there is no gross conformational change upon metabolite binding, which is indicative of a preorganized active

Myosin functions as an ATPase utilizing ATP to produce a molecular conformational change of part of the myosin and produces movement. Movement of the filaments

which digest their content. But the acidic condition triggers a conformational change in the envelope of the virion, making its membrane fuse with the

from the fact that subunit addition at the minus end requires a conformational change of the subunits. Note that each subunit is structurally polar and

with the aromatic ring of the bithionol molecule. This allosteric, conformational change interferes with the ability of the active site of soluble adenylyl

mechanism theory, which postulated that ATP synthesis is dependent on a conformational change in ATP synthase generated by rotation of the gamma subunit. The

activity of the repressor by binding allosterically, resulting in a conformational change of the protein, which suppresses its interactions with RNA polymerase

protein binds cyclic adenosine monophosphate (cAMP), which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters

with another helix in the activating cyclin. Activation induces a conformational change where the helix rotates and moves closer to the N-lobe.[citation

prevent further DNA replication, Lobucavir is thought to cause a conformational change that blocks optimal polymerase activity two to three nucleotides

dimerizes with the corresponding cyclin, cyclin D, which causes a conformational change at the ATP binding site. CDK activating kinase (CAK) then phosphorylates

In the second step, autophosphorylation of Thr-348 leads to a conformational change in the kinase likely supported by the binding of phospho-Thr-348

GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". J. Biol. Chem. 270 (28): 16955–61. doi:10.1074/jbc

proteins bind in a region distinct from fusidic acid to induce a conformational change which results in liberation of EF-G from the ribosome, allowing

allows for the increased processing of pri-miRNAs through an induced conformational change of the DGCR8 subunit, and also enhances DGCR8's binding specificity

N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". The Journal of Biological Chemistry. 270 (28): 16955–61

seen in most bioactive enzymes. One of these subsites induces a conformational change at Tyr-248 upon binding of a substrate molecule at the primary active

for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin

slow isomerisation of the TAP complex’. It is suggested that the conformational change in structure triggers ATP hydrolysis and so initiates peptide transport

guanosine triphosphate (GTP). The exchange of GDP for GTP induces a conformational change of RAS to allow it to bind to Raf-1. Raf-1 is then activated through

developing molecular mechanisms to target and kill pathogens: shape and conformational change of the neutrophil (which allows for transendothelial migration of

influence of an electrochemical gradient. When exposed to a stimulus, a conformational change occurs in the transmembrane region of the protein to open or close

short complementary peptide sequences, causing an “induced fit” conformational change that alters the calmodulin-binding proteins’ activity as desired

compared with the conformations produced by estradiol. The specific conformational change induced by Menerba allows ERβ to bind to an estrogen response element

structural change in the ER. The biological significance of this conformational change was revealed in studies that demonstrated that tamoxifen-resistant

pyrophosphate (TPP). The binding of TPP to the enzyme incurs no major conformational change to the enzyme; instead, the enzyme has two flexible loops at the

calcium saturation activates the kinase and allows it to undergo a conformational change which permits the kinase to bind to its phosphorylation target sites

can be seen as negligible. This change in states is mediated by a conformational change in the protein that has yet to be discovered. Since the alpha helical

N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". The Journal of Biological Chemistry. 270 (28): 16955–61

sequestered by the DNA-binding domain and is released through a conformational change in the DNA-binding domain upon binding to its recognition site.

2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation".

S, Palmer M (November 1999). "Streptolysin O: inhibition of the conformational change during membrane binding of the monomer prevents oligomerization

the second DNA strand is excluded. The binding of NTPs causes a conformational change and subsequent hydrolysis allows the dnaB to translocate along the

the A site, C74 of the tRNA stacking with U2590 (2555) induces a conformational change in the ribosome, resulting in movement of U2541 (2506), U2620 (2585)

Khosla C (December 2007). "Transglutaminase 2 undergoes a large conformational change upon activation". PLOS Biology. 5 (12): e327. doi:10.1371/journal

and SDS solutions. These denaturants cause loss of activity and conformational change. A loss of enzyme activity occurs at much lower concentrations of

results suggest that KTN is inherently flexible, undergoing a large conformational change through a hinge motion. The KTN domains of Kef channels interact

structure of citrate synthase revealed a striking example of a conformational change undergone by an enzyme on combination with its substrate by a process

a conformational change occurs. This conformational change in the G protein allows Gα to bind GTP. This leads to yet another conformational change in

Sebti SM, et al. (November 2005). "Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis". Molecular and Cellular Biology. 25

displacement during gap-filling. During the endonuclease activity, conformational change in DNA occurs in a way that exposes the abasic site by bending the

and regions of the brain. As it binds to a glycine receptor, a conformational change is induced, and the channel created by the receptor opens. As the

subunit of the ribosome. Initial dalfopristin binding results in a conformational change of the ribosome, allowing for increased binding by quinupristin

the enzymatic reaction and was shown to be depended upon a slow conformational change of the enzyme. The function of pyridoxal phosphate is to facilitate

instructions encoded in nucleotides. Instead, they replicate by inducing a conformational change in normally folded cellular prion proteins (PrPc) into a misfolded

prevents the substrate from binding to the enzyme inhibitor through conformational change upon allosteric binding. In the presence of a non-competitive inhibitor

Behavior of Heteromeric α1β Glycine Receptors: An Attempt to Detect a Conformational Change before the Channel Opens". Journal of Neuroscience. 24 (48): 10924–10940

some cases) in a pre-pore state. Following this, the large-scale conformational change occurs in which the membrane spanning section is formed and inserted

three central components believed to contribute to this long-range conformational change event are the pH-coupled N2 iron-sulfur cluster, the quinone reduction

skeletal muscle, as it is in cardiac muscle; Cav1.1 undergoes a conformational change which allosterically activates RyR1. In hypokalemic periodic paralysis

enhances the ability of GKRP to bind and inactivate GK. F6P induces a conformational change in GKRP which promotes the formation of the glucokinase-GKRP complex

S2CID 37649159. Viricel W; Mbarek A; Leblond J (2015). "Switchable Lipids: Conformational Change for Fast pH-Triggered Cytoplasmic Delivery" (PDF). Angewandte Chemie

subsequent release of ADP. This process leads to a conformational change in the pump. The conformational change exposes the Na+ ions to the extracellular region

initiating endosome acidification. This acidification results in a conformational change of the viral glycoprotein, initiating membrane fusion of the viral

and a tyrosine on loop C. Upon interaction, the loop undergoes a conformational change and rotates down to cap the molecule in the binding site. Through

active site. Initial activation of the enzyme by PRPP is caused by a conformational change in a "glutamine loop", which repositions to be able to accept glutamine

target protein Binding of cGMP to the regulatory domain induces a conformational change which stops the inhibition of the catalytic core by the N-terminus

IFNAR1. When bound to IFN-ω, the SD1 of IFNAR1 undergoes a major conformational change that is not seen when unbound or bound to IFN-α2. A study reported

3'-UAC-5' anticodon. IF1 binds the 30S subunit first, instigating a conformational change that allows for the additional binding of IF2 and IF3. IF2 ensures

between folding and functional energy landscapes for adenylate kinase conformational change". Nature Communications. 1 (8): 111. Bibcode:2010NatCo...1..111O

begin at the plasma membrane. Phosphorylation by MAPKs results in a conformational change of Elk1. As seen in Figure 2, Raf kinase acts upstream of MAPKs

When an agonist binds to the site, all present subunits undergo a conformational change and the channel is opened and a pore with a diameter of about 0

physically blocks the ion channels when they are open, causing a conformational change in the channel proteins. This increases the affinity of dioscorine

1986). "Control of primer formation for ColE1 plasmid replication: conformational change of the primer transcript". Cell. 44 (1): 125–136. doi:10.1016/0092-8674(86)90491-5

interactions to occur. In its inactive state, the complex experiences a conformational change that causes both sites to be covered, preventing its primary functions

gated phosphate release. The hydrolysis of eIF2-GTP provides the conformational change to change the scanning complex into the 48S Initiation complex with

reaction phosphoglycerate kinase undergoes a substrate induced conformational change similar to another metabolic enzyme called hexokinase. Because two

GPCR. Binding of a primary messenger to these receptors results in conformational change of the receptor. The α subunit, with the help of guanine nucleotide

β2 microglobulin-free heavy chains of HLA-B27 undergo a facile conformational change in which the C-terminal end of domain two, consisting of a long

(GPCR). When a GPCR is activated by its extracellular ligand, a conformational change is induced in the receptor that is transmitted to an attached intracellular

2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation".

binding and hydrolysis of ATP. The hydrolysis of ATP also causes a conformational change within the nitrogenase complex, bringing the Fe protein and MoFe

the extracellular domain of the hERG channel, this propagates a conformational change and inhibits the current. This change makes the activation gate

assembly of pre-catalytic spliceosome RNA splicing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) Sources:Amigo / QuickGO

enzyme activity and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit. Pertussis toxin is

In the second step, autophosphorylation of Thr-348 leads to a conformational change in the kinase likely supported by the binding of phospho-Thr-348

and dUMP. The mutant TS is unable to accomplish the C-terminal conformational change needed to break covalent bonds to form dTMP, thus showing the proposed

adjacent monomer. The binding of D4 to the membrane surface triggers a conformational change in domain 3, which rotates β5 away from β4, exposing β4 allowing

Following ATP binding and hydrolysis, the complex undergoes a conformational change, flipping a cholesterol molecule into the outer membrane leaflet

the transfer of energy from ATP to the protein myosin causes a conformational change when connecting to actin during muscle contraction. It takes multiple

inactive. Ligand binding to one subunit would induce an immediate conformational change of that subunit from the inactive to the active conformation, a

first followed by the lactate anion. The protein then undergoes a conformational change to a new 'closed conformation that exposes both the proton and lactate

residues that either change their spatial arrangement due to a conformational change induced by glucose or reside in the glucose-binding pocket whereby

binds NADH. Binding of NADH to the Rossmann fold triggers small conformational change typical in the binding of NADH to most dehydrogenases resulting

Bioscience Database. Maki-Yonekura S, Yonekura K, Namba K (April 2010). "Conformational change of flagellin for polymorphic supercoiling of the flagellar filament"

residues that either change their spatial arrangement due to a conformational change induced by glucose or reside in the glucose-binding pocket whereby

that the loss of the hydrogen bonding from glutamate leads to a conformational change that distorts the active site and alters the substrate binding,

channels along the membrane of the endoplasmic reticulum causing a conformational change, which opens the channels and subsequently releases Ca2+ ions into

plate. The binding of two acetylcholine molecules results in a conformational change in the receptor that opens the sodium-potassium channel of the nicotinic

blue-shifted fluorescent protein will be fluorescent. However, a conformational change caused by calcium binding repositions the red-shifted fluorescent

to troponin. Troponin and the associated tropomyosin undergo a conformational change after calcium binding and expose the myosin binding sites on actin

retinal pigment covalently linked to the protein, that results in a conformational change of the molecule that is transmitted to the pump protein associated

"Reversible deactivation of beta-lactamase by quinacillin. Extent of the conformational change in the isolated transitory complex". The Biochemical Journal. 237

binds to the GR inducing a conformational change and GC-GR dimerization. It was previously thought that this conformational change was necessary to dissociate

(Arp2/3 complex) and induce an activating conformational change of the Arp2/3 complex. Due to this conformational change, NPFs initiate polymerization of a new

might present a consumption of catalytic energy. Nevertheless, the conformational change produced in a subunit when changing from the B state to the U state

with a proline residue the alpha helix is broken, introducing a conformational change to the C-terminal domain, separating it from the N-terminal domain

arrestin to the plasma membrane. Receptor binding induces a global conformational change that involves the movement of the two arrestin domains and the release

through a conformational change when it is bound to the pre-mRNA, it transitions from an open state to a closed, folded state. The conformational change results

of the cell. Laniquidar works to inhibit the efflux by causing a conformational change of P-gp. This hinders ATP hydrolysis and the substrate can not be

Hanein D, Matsudaira P, DeRosier DJ (October 1997). "Evidence for a conformational change in actin induced by fimbrin (N375) binding". J. Cell Biol. 139 (2):

phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange

Pseudin-2 binding to the cell membrane of the bacteria results in a conformational change in which the peptide forms an α-helical shape, which allows it to

buried by the binding. Overall binding takes place with very little conformational change in either protein. There are three clusters of residues on eVP24

fitting to build a model. A comparison of the structures suggested a conformational change that involves pivoting of a transmembrane, four-helix bundle (M1

with C3b before to form the C3bB complex. It is proposed that this conformational change of Factor B in the C3bB complex allows Factor B to fit into the

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

called corepressors are bound by the repressor protein, causing a conformational change to the active site. The activated repressor protein binds to the

JC, van Aalten DM (August 2003). "Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes". The

altered to high affinity through an external agonist which causes a conformational change within the integrin, increasing their affinity. An example of this

1074/jbc.M110027200. PMID 11700327. Fu L, Liang JJ (February 2002). "Conformational change and destabilization of cataract gammaC-crystallin T5P mutant". FEBS

phospholipids, suggesting that the binding to the membrane induces a conformational change allowing it to become susceptible to MinE activation. MinD activity

made accessible after the riboswitch undergoes a ligand-induced conformational change. In translational repression, the SD is sequestered upon ligand

occurs as the subunits pull closer and close the active site. This conformational change results in the active, closed holoenzyeme. In PLP-deficient murine

When the G protein interacts with the receptor, it undergoes a conformational change that results in the replacement of the GDP molecule that was bound

was the first to propose that protein denaturation was a purely conformational change. Mathematics genius, Chen Jingrun invented the Chen's theorem and

Batrachotoxin irreversibly binds to the Na+ channels which causes a conformational change in the channels that forces the sodium channels to remain open.

Miyahara I, Nakajima Y, Hirotsu K, Kagamiyama H (March 2003). "Conformational change in aspartate aminotransferase on substrate binding induces strain

the binding to calmodulin, pp60 SRC (a protein kinase) causes a conformational change in MYLK, activating it and resulting in an increase in phosphorylation

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

fusion activity from strain to strain of both influenza A and C. Conformational change in HEF structure that occur at low pH results in the separation

non-competitively to the RT enzyme (figure 3). The binding causes conformational change in the three-dimensional structure of the enzyme and creates the

symmetric geometry usually shown. The molecule undergoes significant conformational change upon complexation. 18-Crown-6 has a high affinity for the hydronium

the cytoplasm hydrolyzes the Ran-GTP to GDP, and this causes a conformational change in Ran, ultimately reducing its affinity for importin. Importin

directly to the procaspase-9 binding site, but likely induces a conformational change that renders procaspase-9 binding less favorable. Hsp70 is shown

ribosomes are sensitized to modeccin if EF2 is unbound to GTP. A conformational change to the 60S ribosomal subunit is induced by EF2, which is favourable

and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented

Atanasov, Victor; Omar, Yasser (2010-01-01). "Quanta of local conformational change: conformons in α-helical proteins". New Journal of Physics. 12 (5):

back of the macromolecule from the movement it had made or the conformational change it underwent to its original state can be prevented, as is the case

Rhoades lab aims to elucidate the principles that link protein conformational change with structure-function relationships, focusing on understanding

sensitivity to protease digestion in the presence of pRNA. This conformational change may allow TIP5 to interact with other proteins that are required

fusion activity from strain to strain of both influenza A and C. Conformational change in HEF structure that occur at low pH results in the separation

human SUV3p exhibits multiple-substrate unwinding activity upon conformational change". Biochemistry. 43 (16): 4781–90. doi:10.1021/bi0356449. PMID 15096047

dephosphorylation. Upon ATP binding in this pocket, it is believed that a conformational change occurs allowing the rotation of the CA domain to come into contact

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

ribosomes are sensitized to modeccin if EF2 is unbound to GTP. A conformational change to the 60S ribosomal subunit is induced by EF2, which is favourable

Atanasov, Victor; Omar, Yasser (2010-01-01). "Quanta of local conformational change: conformons in α-helical proteins". New Journal of Physics. 12 (5):

When activated MAPK binds to MKB this causes a conformational change of the DUSP region which activates MKP and activated MKP dephosphorylates MAPK thereby

functions:[citation needed] Troponin C binds to calcium ions to produce a conformational change in TnI Troponin T binds to tropomyosin, interlocking them to form

Adenosine 1yt2: Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N APO CRYSTAL

regulatory roles. Ig domain interacts with Leptin and is essential for conformational change in the receptor upon ligand binding. CRH2 is essential for leptin

N; Sutcliffe, MJ; Scrutton, NS (2002). "Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring

cognate G proteins upon binding of a ligand. Ligand binding induces a conformational change that allows the GPCR to activate an associated GTPase. RCC1 is the

multipoles would have to be recalculated whenever a molecule underwent a conformational change. DMA has found extensive use in crystal structure prediction for

RSL loop to form an acyl intermediate. The loop then undergoes a conformational change to the relaxed state irreversibly trapping the protease in an inactive

1. Initial interaction between gp120 and CD4. 2. Conformational change in gp120 allows for secondary interaction with CCR5. 3. The distal tips of gp41

soluble renin as well as non-hydrolytic activation of prorenin via a conformational change in prorenin which exposes the catalytic site to angiotensinogen

the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change". Proceedings of the National Academy of Sciences of the United

are low, INSIG and SCAP no longer bind. Then, SCAP undergoes a conformational change that exposes a portion of the protein ('MELADL') that signals it

proteins like calmodulin and troponin C. Recoverin undergoes a conformational change in a [Ca2+]-dependent way. This protein is myristoylated at its

binding, enzyme kinetics, modes of inhibition as well as protein conformational change. Mass spectrometry is also widely applied. It can be used to characterise

The disease progression in prion diseases is probably due to the conformational change of the prion protein (PrP). PrP changes from alpha-helical conformation

by ActA or VCA, the Arp complex is believed to undergo a major conformational change, bringing its two actin-related protein subunits near enough to

ARF6-GTP (ADP-ribosylation factor 6) in the cytosol, which induces a conformational change that exposes its active site. CTA1 then catalyses the ADP-ribosylation

development, and are designed to change the conformation of aurora A. Conformational change in Aurora A leads to release of N-Myc, which is then degraded in

beta-propeller is a critical component of LDLR and aids in a pH based conformational change. At neutral pH the LDLR is in an extended linear conformation and

the resulting endosome LDLR adopts a hairpin conformation. This conformational change in turn induces the dissociation of the LDL-LDLR complex, allowing

lid. Dissociation to the pro-hexamer dimer can be followed by a conformational change that reorients the two αβ-barrel domains to form the pro-octamer

in two steps. First, AMP must be bound by the enzyme to cause a conformational change in the active site, which allows the reaction to take place. The

hydrolysis drives what is commonly referred to as a “pincer-type” conformational change in the protein binding site. Hsp90, while in the open conformation

Frieden C, Nash WE, Strickler RC (September 1995). "An NADH-induced conformational change that mediates the sequential 3 beta-hydroxysteroid dehydrogenase/isomerase

is present. Upon binding by the hormone the receptor undergoes a conformational change releasing the HSP, and the receptor together with the bound hormone

binds to the enzyme inhibitor antithrombin III (AT), causing a conformational change that results in its activation through an increase in the flexibility

Hanein D, Matsudaira P, DeRosier DJ (October 1997). "Evidence for a conformational change in actin induced by fimbrin (N375) binding". The Journal of Cell

membrane and this relocalisation, together with an ELMO-dependent conformational change in Dock180, is sufficient to promote GTP-loading of Rac. RhoG-mediated

for this activity. However, unlike those in the Ras superfamily, conformational change when shuttling between forms only affects switch I, while switch

catalytic efficiency. Binding of cholesterol results in an enzymatic conformational change and a subsequent induced fit of the active site around the cholesterol

strands in two sheets. The active site is buried and requires a conformational change to allow the substrate access. The N2 and N3 N-terminal domains

regulation of gene products. Binding of thyroid hormone results in a conformational change in helix 12 of the TR transactivation domain, which displaces the

remaining three monomers in the tetramer, where it induces a similar conformational change in the other heme sites such that binding of oxygen to these sites

Neurotransmitter binds to the receptor The receptor undergoes a conformational change to allow G-protein complex binding GDP is exchanged with GTP upon

change the tertiary structure, causing the protein to unfold. This conformational change in the protein is thought to be responsible for exposing active

Shah RR, Pedersen LC, Tropsha A, Pope RM, Liu J (April 2004). "A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding

Neurotransmitter binds to the receptor The receptor undergoes a conformational change to allow G-protein complex binding GDP is exchanged with GTP upon

5HT1D receptor agonists. When sumatriptan binds there is major conformational change in both ligand and receptor in the binding pocket. 5-(Nonyloxy)tryptamine

preformed DDR dimers on cell membrane, when collagen is bound, a conformational change probably occurs, which causes cytosolic kinases to rotate to face

used for studies of replication and pathogenesis. Binding causes a conformational change in the viral capsid proteins, and myristic acid is released. The

Rudradip; Bhattacharyya, Maitree (2015). "Transition Metal Induced Conformational Change of Heme Proteins". Spectroscopy Letters. 48 (5): 324–330. Bibcode:2015SpecL

active site of APC. Once cleaved by APC, PCI undergoes a significant conformational change that traps the enzyme in a covalently bonded, inactive state. This

metal binding motif is largely solvent exposed in Apo-ATOX1 and a conformational change is induced upon coordination to Cu(I). Cu(I) is coordinated in a

mediated pathway. Acidification of the late endosome triggers a conformational change in the E proteins, resulting in fusion, followed by uncoating, and

once a red photon has been absorbed, the pigment undergoes a rapid conformational change to form the Pfr state. Here fr indicates that now not red but far-red

phosphorylates the serine residue of the R-SMAD. Phosphorylation induces a conformational change in the MH2 domain of the R-SMAD and its subsequent dissociation

opening to allow the substrate to enter. Therefore, a significant conformational change must occur to provide access and space for a ligand in the active

of residues essential for enzyme activity and the Ca(2+)-induced conformational change". Biochemistry. 43 (28): 9185–94. doi:10.1021/bi049565o. PMID 15248776

compartment then decreases from proton influx, and this causes a conformational change in HA that forces the HA2 subunit to “flip outward.” The HA2 subunit

N-terminus of the NFAT proteins. This dephosphorylation results in a conformational change that exposes a nuclear localization signal which promotes nuclear

also interact with MinD only when on the membrane, suggesting a conformational change in MinD upon interacting with phospholipids that makes it vulnerable

suggest this change may sterically and/or electrostatically hinder a conformational change necessary for catalysis. PDB: 1TJW​; Sampaleanu LM, Codding PW,

hydrolyzes into its active form, C3(H2O). This activation induces a conformational change in the thioester domain of C3(H2O) that allows it to bind to a plasma

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

Cindy L. Will; Reinhard Lührmann; Holger Stark (2005-03-18). "Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12

in greater binding affinity for the ligand. As a result of this conformational change, the ligand is effectively locked in place despite tension exerted

This insertion repositions nucleotides of helix 44, transmitting a conformational change over a 70Å distance and rotating the head of the 30S subunit. IF-1

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death". Mol. Cell. 18 (6): 637–50. doi:10.1016/j.molcel

the same residues adopted an open finger-like conformation. Such conformational change was confirmed by NMR spectroscopy, X-ray crystallography and molecular

proposed how BCR-antigen binding induces phosphorylation, including conformational change of the receptor and aggregation of multiple receptors upon antigen

oligomerise to form a large circular pore (figure 2). A concerted conformational change within each monomer then results in two α-helical regions unwinding

in Chemistry in 1997, suggests that ATP synthesis is linked to a conformational change in ATP synthase. This change is triggered by the rotation of the

to move in the lipid bilayer. This movement in turn results in a conformational change in the adjacent S5–S6 helices that form the channel pore and cause

conservation. The conversion of the 128th aspartic acid to glycine causes conformational change according to CD spectral analysis and thermal lability in mutagenic

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

Study of this residue has shown that phosphorylation promotes a conformational change that prevents ATP and substrate binding by steric interference with

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

LACV in arthropod cells. Acidification of the endosome triggers a conformational change in the Gc fusion peptide, uncoating the ribonuclearprotein (RNP)

to a site on the protein other than the active site, causing a conformational change and altering the activity of that given protein or enzyme. Pyruvate

tonoplast by P1/P2. The capsid dissociates from CPB. CPB undergoes a conformational change into TLS (tRNA-like structure). P1/P2 bind to the minus- strand

isomerization) of retinal from cis to trans or vice versa induces a conformational change in the receptor protein. This change acts as a molecular switch

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

vesicle to drop. The lowering of pH in the early-endosome causes a conformational change in the spike protein G. This allows the viral envelope to fuse with

its receptor CCR7 expressed on the T cell. This binding induces a conformational change in the LFA-1 molecule causing it to bind tightly to ICAM-1. This

of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis". J Biol Chem. 290 (16):

of viral entry: 1. Initial interaction between gp120 and CD4. 2. Conformational change in gp120 allows for secondary interaction with CXCR4. 3. The distal

needed] to the Rev-Erb ligand-binding pocket. Rev-Erbβ undergoes a conformational change when complexed with heme, as its structure shows that helices 3

adinazolam, or other benzodiazepines, acts as an agonist by inducing a conformational change in the benzodiazepine receptor which increases the affinity toward

of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis". J Biol Chem. 290 (16):

of viral entry: 1. Initial interaction between gp120 and CD4. 2. Conformational change in gp120 allows for secondary interaction with CXCR4. 3. The distal

ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations"

to a site on the protein other than the active site, causing a conformational change and altering the activity of that given protein or enzyme. Pyruvate

DNA–adenylate intermediate, allows DNA ligase I to institute a conformational change in the DNA for the isolation and subsequent repair of the DNA nick

protein ELMO has been shown to bind DOCK proteins and induce a conformational change which relieves the inhibition and allows G proteins access to the

May AP, Sousa MC (June 2005). "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin

in the cell membrane. Sortilin has also been shown to undergo a conformational change and form a protein dimer in acidic conditions similar to ones found

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

simple noncovalent lock and key mechanism; while yet others use a conformational change-based trapping mechanism that depends on their structural and thermodynamic

differences. The nucleotide differences are unlikely to cause a conformational change in the enzyme but rather site-specific alterations. This seems logical

glucose. As GLUT 1 is a type of carrier protein, it will undergo a conformational change to allow glucose to enter the other side of the plasma membrane

closes off the internal space, the archaeal thermosome undergoes a conformational change to close the openings at each end via the hydrolysis of ATP. The

allows faster electron transfer. A gating mechanism involving the conformational change of the Leu41’s non-polar sidechain further stabilizes the Fe2+ oxidation

neurons. Benzodiazepines bind to the GABAA receptor inducing a conformational change leading to an increased affinity to GABA. The allosteric binding

tract and bladder tissue. Upon binding, the β3 receptor undergoes a conformational change. This induces the activation of adenylate cyclases via G proteins

the active site in the p66 subdomain. Their binding results in a conformational change in the reverse transcriptase that distorts the positioning of the

1016/0959-440x(95)80072-7. PMID 7648318. Orlova A, Egelman EH (Jul 1993). "A conformational change in the actin subunit can change the flexibility of the actin filament"

Gerstein, Mark Bender (1992). Protein recognition : surfaces and conformational change (PhD thesis). University of Cambridge. Gerstein, M.; Chothia, C

S2CID 18376541. Hawthorne R, Lynch JW (October 2005). "A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop". The Journal of Biological Chemistry

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

bond between Cys38 and Cys83 of the protein forms and causes a conformational change to move HisE7 out of the way, allowing oxygen to bind. Thus, oxygen

M; Mkrtchian, S; Tsai, B (28 October 2005). "ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding". Molecular Cell.

because it is a monomer (i.e., it does not undergo a significant conformational change with oxygenation). Thus, myoglobin remains fully saturated at O2

binding pocket between the beta sheets. The binding of cNMP causes a conformational change that affects the protein's activity. There is also data to support

to act on its target. The low pH of the vesicle lumen causes a conformational change in the toxin, shifting it from a water-soluble form to a hydrophobic

Gutowsky used NMR to study mechanisms of chemical exchange and conformational change of molecules. Gutowsky's work was essential both in understanding

and Glu262, respectively, and are likely to be protonated. The conformational change associated with substrate binding reorients the cluster. The residue

Incoming sweet molecules bind to their receptors, which causes a conformational change in the molecule. This change activates the G-protein, gustducin

PS; Bezanilla F. (August 2008). "Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels". Journal

together and the α-subunit binds GDP. G protein activation causes a conformational change, which leads to the exchange of GDP for GTP. GTP-binding to the

the nucleus where it associates with RBPJ. The binding causes a conformational change which leads co-repressors to disassociate and allows co-activators

too activate caspase-8 to cleave and translocate Bid, induced a conformational change in and translocation of Bax and cytochrome-c release. Apoptosis

once believed that this glucose trimming is responsible for the conformational change needed for LPL to form homodimers and become catalytically active

Once in the cytoplasm, RanGAP hydrolyzes GTP to GDP, causing a conformational change that releases the pre-miRNA into the cytoplasm. It has been suggested

through the protonation state of Hisα222 Nԑ. Additionally, the conformational change from the open to closed state of the mobile flap generates a rearrangement

thereby sensing the NADH/NAD+ ratio. When bound, it undergoes a conformational change that allows it to dimerize and associate with its partner proteins

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

the key event in polymerization is probably the propagation of a conformational change from the centre of the bond with the nucleotide to this domain,

May AP, Sousa MC (June 2005). "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin

sodium-ion channel that stays open longer. Aconitine suppresses the conformational change in the sodium-ion channel from the active state to the inactive

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

domains can also bind calcium ions, and the binding results in a conformational change that dissociates the mitochondrial surface from kinesin. RHOT2 is

prevents it from auto-oxidising in an alkaline pH. It releases it by a conformational change in acidic pH, activating luciferin. This activation then allows

This occurs because when the ligand binds to the receptors, a conformational change occurs in them that potentially blocks the proteolytic activity

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair". J. Mol. Biol. 396 (3): 800–20. doi:10.1016/j

May AP, Sousa MC (June 2005). "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin

structures of pectin lyase A from Aspergillus reveal a pH driven conformational change and striking divergence in the substrate-binding clefts of pectin

and TyeA are positioned as a plug on the apparatus so only their conformational change, induced by their interaction with certain host cell membrane proteins

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

yeast is a translation termination factor. When Sup35 undergoes a conformational change to the [PSI+] prion state, it forms amyloid fibrils and is sequestered

synthase (nNOS). PSD95 and nNOS coupling to the NMDA receptor causes a conformational change responsible for the intracellular influx of Ca2+ which could in

penetrates, or pushes into, the DNA minor groove and induces a conformational change to flip the nucleotide out of the helix. Backbone compression favors

binding of the second, third and fourth, this is due to the induced conformational change in the structure of the hemoglobin molecule induced by the binding

binding of a ligand to the extracellular domain of the GPCR, a conformational change is induced in the receptor that allows it to interact with the alpha-subunit

move closer together. When a substrate binds to the enzyme, the conformational change causes the domains to clamp around the substrate at the active site

However, in the presence of calcium ions, the protein undergoes a conformational change and converts its prosthetic group, coelenterazine-2-hydroperoxide

of other van der Waals interactions, this bonding facilitates a conformational change of the DNA-enzyme complex which leads to the activation of catalytic

movement of the IVS4 transmembrane segment. This blockage prevents the conformational change that is essential for inactivation. The prolongation of the inactivation

binding to AT via a pentasaccharide sequence. This binding leads to a conformational change of AT, increasing the rate at which it inhibits activated factor

histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

doi:10.1351/goldbook.C01480 Jeffrey I. Seeman (1983). "Effect of Conformational Change on Reactivity in Organic Chemistry. Evaluations, Application, and

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

typically occurs on a specific threonine residue, leading to a conformational change in the CDK that enhances its kinase activity. The activation forms

the double helix and into the active site pocket. UDG undergoes a conformational change from an ‘‘open’’ unbound state to a ‘‘closed’’ DNA-bound state.

a novel peroxidase mechanism; a protein-protein or Ca2+ induced conformational change which subsequently allows heme binding for peroxidase activity;

translocating the enzyme from cytosol to membrane, and producing a conformational change that removes auto-inhibition of the PKC catalytic protein kinase

Mad1:Mad2 template. This Mad1:Mad2 interaction is thought to enable a conformational change which allows the peripherally bound Open Mad2 to interact with Cdc20

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

bridge between the two Mn2+ ions, the GlyPro substrate causes a conformational change as it binds to the active site. This GlyPro is held in place by

correct base pairing between the crRNA and the protospacer signals a conformational change in Cascade that recruits Cas3 for DNA degradation. Type II systems

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

growth factors to their receptor tyrosine kinases (RTK) triggers a conformational change and promotes dimerization and autophosphorylation of tyrosine residues

and Peter King "Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl." FEBS Lett. 2009, 583, 2899-2906 doi:10.1016/j

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

Polymer-bundling by the Escherichia coli ZapA Orthologue, YgfE, Involves a Conformational Change in Bound GTP’ 2007, Journal of Molecular Biology, 369: 210-221.

hypothesized that serine phosphorylation of this protein induces a conformational change to its secretory form. The mechanism that GPI uses to interconvert

of protons through this enzyme causes mechanical movement and a conformational change in the enzyme that combines ADP and inorganic phosphate to produce

electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen

Zhang Z, Akhter S, Mottl S, Jin JP (Sep 2011). "Calcium-regulated conformational change in the C-terminal end segment of troponin I and its binding to tropomyosin"

positions. Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing the inhibitory effects of GABA. It acts as a positive