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searching for Affinity 429 found (18684 total)

alternate case: affinity

Cooperativity (1,951 words) [view diff] exact match in snippet view article find links to article

this is enzymes or receptors that have multiple binding sites where the affinity of the binding sites for a ligand is apparently increased, positive cooperativity

binding affinity. In general, high-affinity ligand binding results from greater attractive forces between the ligand and its receptor while low-affinity ligand

blockers, and calcium channel blockers. In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the

The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. It

Chebib M, Wellendorph P (August 2012). "α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)". Proceedings of the National Academy

vocabulary was introduced by Benoit Mandelbrot in 1964. In mathematics, self-affinity is a feature of a fractal whose pieces are scaled by different amounts

receptor (i.e. affinity), increasing its ability to activate the receptor (i.e. efficacy), or both. Negative types decrease the agonist affinity and/or efficacy

bicalutamide. It also has slightly higher affinity for the AR than DHT and nearly equal affinity to that of the very-high-affinity AR ligand metribolone (R-1881)

In Euclidean geometry, an affine transformation or affinity (from the Latin, affinis, "connected with") is a geometric transformation that preserves lines

a non-selective, high-affinity, weak partial agonist of the μ- (MOR), κ- (KOR), and δ-opioid receptor (DOR) (with equal affinity) which is used in veterinary

has 24% of the affinity of ORG-2058 and 186% of the affinity of progesterone for the progesterone receptor, 4.5% of the affinity of testosterone for

induces a conformational change in the enzyme that can either reduce the affinity of the active site for the substrate or alter the enzyme's catalytic activity

Dick's stores and close to 100 Golf Galaxy locations. The company acquired Affinity Sports, Blue Sombrero, and GameChanger. Edward W. Stack is currently the

Cannabinol (CBN) is a mildly psychoactive phytocannabinoid that acts as a low affinity partial agonist at both CB1 and CB2 receptors. This activity at CB1 and

synthetic steroidal estrogen which was never marketed. It has very high affinity for the estrogen receptor and dissociates from it relatively slowly. It

catalytic subunit of an enzyme, this can trigger an increase in the substrate affinity as well as catalytic activity in the enzyme's other subunits, and thus

terms of relative binding affinity (RBA) for the rat uterine estrogen receptor, 16α-hydroxyestrone showed 2.8% of the affinity of estradiol. For comparison

Coumestrol has about the same binding affinity for the ER-β estrogen receptor as 17β-estradiol, but much less affinity than 17α-estradiol, although the estrogenic

higher hemoglobin-oxygen affinity when compared to the mortality rate of offspring from women with low hemoglobin-oxygen affinity. While the exact genotype

uncertainty; the goal of science is to move "form taxa" to biological taxa whose affinity is known. Form taxonomy is restricted to fossils that preserve too few

gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism. Most of the PDE families

increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also

receptors with preferential affinity for the μ-opioid receptor (approximately 6x that of morphine), similar but slightly lower affinity for the δ-opioid receptor

7-fold higher affinity for ERβ and appears to have higher intrinsic activity in activating ERβ. However, both enantiomers have very high affinity, potency

6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221

The Fender Stratocaster, colloquially known as the Strat, is a model of double-cutaway electric guitar designed between 1952 and 1954 by Leo Fender, Bill

7-fold and 94-fold higher affinity for the human AR than bicalutamide (0.66% and 17% of the RBATooltip relative binding affinity of metribolone, respectively

drug's affinity and efficacy. Affinity describes how well a drug can bind to a receptor. Faster or stronger binding is represented by a higher affinity, or

7-fold higher affinity for ERβ and appears to have higher intrinsic activity in activating ERβ. However, both enantiomers have very high affinity, potency

Instead, it lies between its low-activity, low-affinity "tense" and its high-activity, high-affinity "relaxed" states. The binding of substrate to the

receptor affinity and κ-opioid receptor agonist potency, Arg6 and Arg7 promote κ-opioid affinity and Lys10 contributes to the opioid receptor affinity. Cannabinoid

the physiologic function of estrogen because metalloestrogens have shown affinity for estrogen receptors. Because they can mimic estrogen thus activating

has low affinity to the μ-opioid receptor (MOR) and the κ-opioid receptor (KOR) (13% of MOR and 17% of KOR occupancy at 100 μM), but no affinity to DOR

Cheng and William Prusoff (see Ki). IC50 is not a direct indicator of affinity, although the two can be related at least for competitive agonists and

The Fender Stratocaster, colloquially known as the Strat, is a model of double-cutaway electric guitar designed between 1952 and 1954 by Leo Fender, Bill

Johnson but never marketed. It exerts its pharmacological effect through affinity for dopamine D2, serotonin 5-HT1A, and α1-adrenergic receptors. Mazapertine

nucleotidase(cN) characterized by its affinity toward AMP as its substrate. cN-II is identified by its affinity toward either IMP or GMP or both. cN-III

μ-opioid receptor affinity, herkinorin is predominantly a μ-opioid receptor agonist. Compared to salvinorin A, herkinorin has 47× lower affinity for κ-opioid

well as showing a little affinity for the α1 or α5 subtypes — alpidem is selective for α3 over α2, but still has moderate affinity for α1, whereas adipiplon

the ERβ is 0.24 nM, a 4-fold difference in affinity, whereas estradiol is considered to have similar affinity for the two receptor subtypes. Unlike the

in November 2016. In June 2019 it was officially replaced by Serif with Affinity Publisher. PagePlus was first launched in 1990 and was the first sub-£100

important role in σ receptor binding affinity, with alterations made to these groups leading to changes in affinity to σ1. Replacement side groups that

6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221

never marketed. It shows 163% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors. Cyanonilutamide

Evian (/ˈeɪviɒn/ AY-vee-on, ev-ee-un; French: [evjɑ̃], stylized as evian) is a French brand that bottles mineral water from several sources near Évian-les-Bains

of the 19-norprogesterone group which was never marketed. It has high affinity for the progesterone receptor (775% of that of progesterone) and has been

7-fold and 94-fold higher affinity for the human AR than bicalutamide (0.66% and 17% of the RBATooltip relative binding affinity of metribolone, respectively

meso-butoestrol. The affinity of DMS for the ER was reported as about 10% of that of estradiol. For comparison, diethylstilbestrol had 140% of the affinity of estradiol

other hand, gestronol had far higher affinity than 17α-hydroxyprogesterone, which showed less than 0.1% of the affinity of progesterone for the progesterone

highest affinity, but also binds D1 and D5. Haloperidol also has a risk for QTc prolongation. Fluphenazine binds D2 and D3 with the highest affinity but D1

research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα. (R,R)-THC is a silent antagonist of ERβ, and,

nucleophiles donate electrons, they are Lewis bases. Nucleophilic describes the affinity of a nucleophile to bond with positively charged atomic nuclei. Nucleophilicity

improved potency relative to bicalutamide, with approximately 150-fold higher affinity for the AR (Ki = 0.15 nM versus 22.3 nM) and about 20-fold greater functional

be highly selective CB2 agonists with little affinity for CB1. However, low nanomolar CB1 binding affinity is retained with certain heterocyclic 1-position

oxygen in the blood (PO2), and is determined by what is called "hemoglobin affinity for oxygen"; that is, how readily hemoglobin acquires and releases oxygen

major opioid receptors—μ, κ, and δ, but with a significant preference in affinity for the μ receptor and the κ2 subtype. As such, it has been touted as a

properties to PCP, with more affinity for the NMDA receptors, but less affinity for the sigma receptors. Because of its high affinity for the PCP site of the

surprisingly weak binding affinity of 2695 nM at 5-HT2A with negligible affinity at 5-HT2C,: 737  making it only slightly higher affinity than mescaline, despite

trenbolone was found to possess the same affinity for the AR as dienolone but several-fold increased affinity for the PR. Dienedione (the 17-keto analogue

to be further metabolized. 16α-OHP has approximately 67% and 43% of the affinity of progesterone for the PR-A and PR-B, respectively, and acts as an agonist

Carazolol is a high affinity inverse agonist (also referred to as a beta blocker) of the β-adrenergic receptor. Innis RB, Corrēa FM, Synder SH (1979).

homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall

agonist with 10-fold selectivity (i.e., affinity) for the ERβ over the ERα and with 20-fold greater affinity for the ERβ relative to that of (S,S)-THC

very low-affinity CB1 ligand, that can nevertheless affect CB1 receptor activity in vivo in an indirect manner, while THCV is a high-affinity CB1 receptor

approximately equivalent affinity for the rat ventral prostate androgen receptor (AR) relative to that of spironolactone. The affinity of 7α-TS, 7α-TMS, and

lead compound among a series of androsta-3,5-dienes as ERβ ligands. Its affinity (IC50) for the ERβ was found to be 9 nM and it showed 62- and 160-fold

was never marketed. It shows 92% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors. The

generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity

low or no affinity for the 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT (Ki = all > 1 μM), but it does have some affinity for the α2-adrenergic

lead compound among a series of androsta-3,5-dienes as ERβ ligands. Its affinity (IC50) for the ERβ was found to be 9 nM and it showed 62- and 160-fold

was never marketed. It shows 92% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors. The

Carazolol is a high affinity inverse agonist (also referred to as a beta blocker) of the β-adrenergic receptor. Innis RB, Corrēa FM, Synder SH (1979).

receptor agonist from the naphthoylindole family. It has approximately equal affinity for the CB1 and CB2 receptors, with a Ki of 6.6 nM at CB1 and 6.9 nM at

was originally used as an insecticide. The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found

cancer and autoimmune disorders. The antibody is engineered for enhanced affinity to the CD20 antigen on B-lymphocytes, increased antibody-dependent cell-mediated

analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 26.0 nM, making it more potent than THC itself,

It shows modest selectivity in terms of affinity and transactivation for the ERβ over the ERα. Its affinity for the ERβ was 3.43 μM and for the ERα was

in their binding affinity. The antibody with the higher affinity for a specific epitope will surpass antibodies with a lower affinity for the same epitope

found to have significant cannabinoid receptor affinity, and while AM-679 itself has only modest affinity for these receptors, it was subsequently used

show 5- to 8-fold higher affinity for the AR than the first-generation NSAA bicalutamide, and only 2- to 3-fold lower affinity than dihydrotestosterone

operating system, or the routing of interrupts (usually referred to as IRQ affinity) can be manually configured. A purely software-based implementation of

an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood–brain barrier penetration and high affinity for

sigma σ1 and σ2 receptor agonist (with similar affinity for both subtypes, though slightly higher affinity for the latter) and D2 receptor partial agonist

CJC-1295 DAC, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing

advances in mice. It binds to the 5-HT6 serotonin receptor with 10x less affinity. At relevant doses, inhibition of 5-HT6 would be expected to render pro-cognitive

relatively low affinity for the androgen receptor but shows significant antiandrogenic activity in animals. RU-59416 has very low affinity for the androgen

in the positions 23, 25 and 26 that is believed to have a role in the affinity for the channels. There are also two highly conserved amino acid residues

cocaine abuse, bipolar disorder, and cancer. Much is known about the binding affinity of hundreds of synthetic compounds to the σ1 receptor. An endogenous ligand

A loyalty program or rewards program is a marketing strategy designed to encourage customers to continue to shop at or use the services of one or more

activity at other opioid receptors. It has only moderate affinity for the mu opioid receptor, weak affinity for the kappa opioid receptor and negligible binding

water molecules, are more numerous in the homologous complexes of low affinity. Carefully conducted mutagenesis experiments, e.g. changing a tyrosine

derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around tenfold selective

day", she said. Affinity won the Stonewall Book Award and Somerset Maugham Award. Andrew Davies wrote a screenplay adapting Affinity and the resulting

Sunobinop (developmental code names V117957; IMB-115) is a high affinity small molecule nociceptin receptor partial agonist. As of February 2024, it is

bound the substrate. This is unlike competitive inhibition, where binding affinity for the substrate in the enzyme is decreased in the presence of an inhibitor

be similar to THC, the natural cannabinoid with the strongest binding affinity to the CB1 receptor, which is linked to the psychoactive effects or "high"

kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), and selectivity vs. the

phenylacetylindole family that acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0 nM at CB1 and 7.0 nM

the seventh transmembrane segment could be involved in the selection and affinity of transported substrate. Each glucose transporter isoform plays a specific

are: HU-210 — a high affinity CB1 agonist (Ki = 0.23 nM) HU-211 — the (+)-enantiomer of HU-210 with dramatically reduced CB1 affinity HU-239 — also known

receptor antagonist, with negligible affinity for the 5-HT1A or 5-HT2C receptors, and over 400-fold lower affinity for the D2 receptor in comparison to

progesterone, 19-norprogesterone is a potent progestogen and possesses high affinity for the mineralocorticoid receptor (MR). However, unlike progesterone,

hemoglobin's affinity and carrying capacity for oxygen. The Root effect is to be distinguished from the Bohr effect where only the affinity to oxygen is

SNX-482 is a toxin from the tarantula Hysterocrates gigas. It acts as a high-affinity blocker of R-type Ca2+ (Cav2.3) channels, but at higher concentrations

of desogestrel. Etonogestrel has about 150% of the affinity of promegestone and 300% of the affinity of progesterone for the PR. Desogestrel (via etonogestrel)

4-methylpregabalin, was both 4× higher in binding affinity to α2δ channels than pregabalin, and also retained similar affinity for the system L transporter. This was

the same time.: 134  This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate

highly selective, high-affinity, competitive silent antagonist of the androgen receptor (AR). Both agents show much higher affinity and more potent inhibition

of desogestrel. Etonogestrel has about 150% of the affinity of promegestone and 300% of the affinity of progesterone for the PR. Desogestrel (via etonogestrel)

4-methylpregabalin, was both 4× higher in binding affinity to α2δ channels than pregabalin, and also retained similar affinity for the system L transporter. This was

are: HU-210 — a high affinity CB1 agonist (Ki = 0.23 nM) HU-211 — the (+)-enantiomer of HU-210 with dramatically reduced CB1 affinity HU-239 — also known

Siderophores (Greek: "iron carrier") are small, high-affinity iron-chelating compounds that are secreted by microorganisms such as bacteria and fungi.

Toxicology as a potential treatment for opioid dependence. It is a high-affinity, balanced ligand of the μ- (Ki = 0.22 nM), δ- (Ki = 0.69 nM), and κ-opioid

The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody

the piperidine ring introduces steric hindrance which prevents μ-opioid affinity from increasing much further. As with other 3-substituted fentanyl derivatives

served as a lunch and dinner dish. Some notable people have professed an affinity for the dish, such as American entrepreneur Duncan Hines and the Manchurian

CM156 is a piperazine based chemical compound with nanomolar affinity for both sigma receptor subtypes that has been shown to counteract the deleterious

4-fluoro analogue of estradiol. 4-Fluoroestradiol has 180 ± 43% of the affinity of estradiol for the estrogen receptor of rat uterine cytosol and shows

dexamethasone that also selectively binds to the glucocorticoid receptor with high affinity. This is in contrast to the natural steroid hormones cortisol or corticosterone

2-hydroxyestrone and 2-methoxyestradiol, 2-methoxyestrone has very low affinity for the estrogen receptor and lacks significant estrogenic activity. 2-Methoxyestradiol

blood pH will rise, leading to respiratory alkalosis. This increases the affinity of oxygen to hemoglobin and makes it harder for oxygen to be released into

of 1 nM, a significantly higher affinity than older 5-HT6 agonists such as EMDT, although it possesses moderate affinity for the 5-HT3 receptor as well

as a progestogen in animals; it was reported to possess 500 times the affinity of progesterone for the progesterone receptor expressed in rabbit uterus

Wyeth-Ayerst. It acts as a balanced, modest affinity D2 and 5-HT2 receptor antagonist and also possesses high affinity for the sigma receptor. It was well tolerated

but considerable affinity for the progesterone receptor (PR) and the glucocorticoid receptor (GR) (RBATooltip relative binding affinity = 21% and 61% of

receptor, labeled either with carbon-11 or fluorine-18. It possesses high affinity for the KOR (Ki = 0.18 nM) and is highly selective for it over the μ-opioid

the affinity of norethisterone for the PRA, whereas the affinity of the two drugs for the PRB is similar (noretynodrel possesses 94% of the affinity of

generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity

by the Danish physiologist Christian Bohr. Hemoglobin's oxygen binding affinity (see oxygen–haemoglobin dissociation curve) is inversely related both to

cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM, but 22x lower affinity for the psychoactive CB1 receptors with

bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter. Both Northern blot analysis and inspection of the

Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily high affinity for biotin (also known as vitamin B7 or vitamin H). With a dissociation

have 10- to 60-fold increased affinity for the estrogen receptor and reduced partial estrogen agonistic activity. The affinity of droloxifene for the estrogen

the polyether influences the affinity of the crown ether for various cations. For example, 18-crown-6 has high affinity for potassium cation, 15-crown-5

The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by the SLC29A4 gene. It is

dihydroalprenolol was able to label beta-adrenergic receptor sites with high affinity. In this way, research of dihydroalprenolol coupled with other co-factors

which can bind to biotin (Vitamin B7, vitamin H) with a high degree of affinity and specificity. The dissociation constant of the avidin-biotin complex

occur naturally in any other species. Deltorphin is one of the highest affinity and most selective naturally occurring opioid peptides known, acting as

adult form, though it is suspected that they are parasites, and their affinity is uncertain. Some researchers believe that they may be larval tantulocaridans

receptor is its binding affinity, which is inversely related to the dissociation constant Kd. A good fit corresponds with high affinity and low Kd. The final

8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist developed by a team at Parke Davis in the 1950s. It is a structural analog of

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the family of serine/threonine

approximately equivalent affinity for the rat ventral prostate androgen receptor (AR) relative to that of spironolactone. The affinity of 7α-TS, 7α-TMS, and

binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene. MARK3 has been shown to interact with Stratifin

scientific research. It shows similar affinity for the serotonin 5-HT2B and 5-HT2C receptors and has ~40-fold higher affinity for the serotonin 5-HT2C receptor

described as an "only relatively weak competitor". Its relative binding affinity for the androgen receptor is about 2.6% of that of metribolone. DIMP possesses

adult form, though it is suspected that they are parasites, and their affinity is uncertain. Some researchers believe that they may be larval tantulocaridans

produce a maximum functional response. This must be distinguished from the affinity, which is a measure of the ability of the drug to bind to its molecular

apparent value of K m {\displaystyle K_{\mathrm {m} }} , or lowers substrate affinity. Graphically this can be seen as the inhibited enzyme having a larger intercept

Razdan at Organix Inc in 2002. It has a CB1 receptor affinity of 2.0 nM and a CB2 receptor affinity of 0.3 nM. Structurally, O-1871 is a cyclohexylphenol

SNX-482 is a toxin from the tarantula Hysterocrates gigas. It acts as a high-affinity blocker of R-type Ca2+ (Cav2.3) channels, but at higher concentrations

Doran. Black had originally been considered for the role of Krista in "Affinity", but her schedule did not allow it. Krista was then played by Erica Durance

γ-lactone ring. As an antiandrogen, 7α-TP4 has approximately 8.5% of the affinity of dihydrotestosterone (DHT) for the rat ventral prostate androgen receptor

have 10- to 60-fold increased affinity for the estrogen receptor and reduced partial estrogen agonistic activity. The affinity of droloxifene for the estrogen

the dopamine D5 receptor (Ki = 13 nM; IA = 81%). It has no significant affinity or functional activity at the D2-like receptors (D2, D3, D4) (Ki ≥ 4,870

Club. Affinity groups include: Black Student Union, Non-Traditional Households Affinity, Christian Affinity, Chinese Affinity, Latin Affinity, LGBTQ

of the phenylpiperazine class which was never marketed. It shows high affinity for the α1-adrenergic receptor and 5-HT1A receptor, among other sites.

selective 5-HT1D agonist, with a 10-fold greater affinity for the 5-HT1B receptor, and 25-fold greater affinity for the 5-HT1A receptor. When L-694247 was injected

dihydroalprenolol was able to label beta-adrenergic receptor sites with high affinity. In this way, research of dihydroalprenolol coupled with other co-factors

research. It has been found to bind with high affinity to the σ1 receptor (Ki = 3.2 nM) and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM)

1-dimethylbenzyl group. It has high binding affinity in vitro for both the CB1 and CB2 receptors, with a CB2 affinity of 0.91 nM and 13-fold selectivity over

Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily high affinity for biotin (also known as vitamin B7 or vitamin H). With a dissociation

cells (RBC; erythrocyte) at approximately 5 mmol/L. It binds with greater affinity to deoxygenated hemoglobin (e.g., when the red blood cell is near respiring

binds to the ERα and ERβ with similar affinity to that of estradiol (94% and 185% of the relative binding affinity of estradiol at the ERα and ERβ, respectively)

physiological pH, it is largely inactive as an H2 antagonist, but its H3 affinity is 100x higher. It is a thiourea derivative. Burimamide was first developed

for lymphoma and myeloma. It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339. "WHO Drug Information" (PDF)

blood pH will rise, leading to respiratory alkalosis. This increases the affinity of oxygen to hemoglobin and makes it harder for oxygen to be released into

which can bind to biotin (Vitamin B7, vitamin H) with a high degree of affinity and specificity. The dissociation constant of the avidin-biotin complex

They constitutively bind as dimers to specific sequences of DNA with high affinity. Family members contain an unusual DNA binding domain that binds to the

are classified according to many parameters, such as chemical structure, affinity, application method, desired colour fastness i.e. resistance to washing

the importance of building the entire affinity diagram in one or two sessions rather than building smaller affinity diagrams over many sessions. This immersion

Amosulalol (INN) is an antihypertensive drug. It has much higher affinity for α1-adrenergic receptors than for β-adrenergic receptors. It is not approved

conserved in all ribosome inactivating proteins. The toxin can be isolated via affinity chromatography, using acid-treated Sepharose 6B. Volkensin, and toxins

5α-dihydronandrolone, 5α-DHNED shows reduced affinity for the androgen receptor relative to norethandrolone. Its affinity for the androgen receptor is specifically

potency relative to estradiol). However, it retains activity as a high-affinity agonist of the G protein-coupled estrogen receptor (GPER) (10 nM, relative

amine-binding affinity varies by VMAT isoform; studies indicate that catecholamines dopamine, norepinephrine, and epinephrine have a threefold higher affinity for

5-HT2 receptors, with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM. It has anxiolytic effects in animal

unusually high affinity, weak partial agonist of the MOR, a high affinity antagonist of the KOR and DOR, and a relatively low affinity, very weak partial

from entering. It modulates IF2 binding to the ribosome by increasing its affinity. It may also prevent the 50S subunit from binding, stopping the formation

5-HT2A, α1-adrenergic, and histamine H1 receptors. It also shows lower affinity for various other targets. Ketanserin was discovered at Janssen Pharmaceutica

MAO-B inhibitor and NDRA, d-deprenyl has been found to bind with high affinity to the σ1 receptor (Ki = 79 nM) similarly to various other amphetamine

nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2 nicotinic acetylcholine receptors but not

molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide

5-HT2 receptors, with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM. It has anxiolytic effects in animal

5α-dihydronandrolone, 5α-DHNED shows reduced affinity for the androgen receptor relative to norethandrolone. Its affinity for the androgen receptor is specifically

potency relative to estradiol). However, it retains activity as a high-affinity agonist of the G protein-coupled estrogen receptor (GPER) (10 nM, relative

The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is

unusually high affinity, weak partial agonist of the MOR, a high affinity antagonist of the KOR and DOR, and a relatively low affinity, very weak partial

from entering. It modulates IF2 binding to the ribosome by increasing its affinity. It may also prevent the 50S subunit from binding, stopping the formation

5-HT2A, α1-adrenergic, and histamine H1 receptors. It also shows lower affinity for various other targets. Ketanserin was discovered at Janssen Pharmaceutica

MAO-B inhibitor and NDRA, d-deprenyl has been found to bind with high affinity to the σ1 receptor (Ki = 79 nM) similarly to various other amphetamine

change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists

serotonin receptors, with highest binding affinity for the 5-HT2C subtype and around four times less affinity for 5-HT2A and 5-HT2B. In drug discrimination

nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2 nicotinic acetylcholine receptors but not

0.1–1 nM), and 5-HT2A (Ki 52 nM) receptors. It also has a high binding affinity for the sigma receptors. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias

resulting 15N labeled proteins are then purified by immobilized metal affinity and their percentage estimated. In order to increase the yield of labeled

muscarinic antagonist known. Tests in vitro showed it to have a binding affinity over 2100 times more potent than 3-quinuclidinyl benzilate (BZ) with an

is a potent dopamine antagonist with high affinity to the D2, D3, and D4 receptors, and with moderate affinity for the 5-HT2 receptors. Carpipramine Clocapramine

for full length heparin, with β-antithrombin having a higher affinity. The higher affinity of β-antithrombin is thought to be due to the increased rate

Advanced Configuration and Power Interface (ACPI) is an open standard that operating systems can use to discover and configure computer hardware components

2% of the affinity of ORG-2058 and less than 2% of the affinity of progesterone for the PR. Similarly, it has less than 0.2% of the affinity of testosterone

as deoxy-Δ8-THC-DMH, is a selective cannabinoid ligand, with a binding affinity of Ki = 2.9 ± 1.6 nM for the CB2 subtype, and Ki = 23 ± 7 nM for CB1. JWH-015

the δ- and μ-opioid receptors with roughly equipotent affinity, and also has similarly high affinity as well as subtype-selectivity for the κ3-opioid receptor

discharge Q, with unit head and thereby is able to produce unit power. Affinity laws allow the output of a turbine to be predicted based on model tests

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. The allergic response involves the

The equilibrium constant of a chemical reaction is the value of its reaction quotient at chemical equilibrium, a state approached by a dynamic chemical

affinity: R5 (or R5M), I1, I2, I3 and R3, tau2, C1, C2 and C3. Between the R1 and R2 high affinity sites exist the R5M, tau2, I1, and I2 low affinity

all except the kappa opioid receptor, at which it has slightly higher affinity than 18-MC. 18-Methylaminocoronaridine 18-Methoxycoronaridine Coronaridine

antiadrenergic, and some antidopaminergic activity. The drug has relatively weak affinity for the dopamine D2 receptor (IC50Tooltip Half-maximal inhibitory concentration

is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5× the affinity at CB2. The abbreviation JWH stands for John W.

Australia, and the United States may find a greater level of community and affinity to similar identities than leitī in the island kingdom. Leitī or fakafefine

for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy. Benzodiazepine

Fallypride is a high-affinity dopamine D2/D3 receptor antagonist used in medical research, usually in the form of fallypride (18F) as a positron emission

right in Europe. Atlanticism often implies an affinity for U.S. political or social culture, or affinity for Europe in North America, as well as the historical

is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) – which is under development

aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC, but its

Some studies also show the drug to have moderate affinity to dopamine D2 receptors and low affinity to dopamine receptor D1. Researchers are looking for

acquired by MacroGenics. It was engineered to increase affinity for CD16A polymorphisms and decrease affinity for FcγRIIB (CD32B), an inhibitory receptor. It

levonorgestrel which is formed by 5α-reductase. It has about one-third of the affinity of levonorgestrel for the progesterone receptor. In contrast to levonorgestrel

than nicotine but weaker than epibatidine in most assays, and with high affinity for both α3β4 and α4β2 subtypes, as well as the less studied α1βγδ subtype

which they share morphological similarities, but have no evolutionary affinity. Muntingia calabura is widely introduced in tropical regions, because of

(previous knowledge of everything) whereas he is not so bold in Phaedo. The Affinity Argument explains that invisible, immortal, and incorporeal things are

levonorgestrel which is formed by 5α-reductase. It has about one-third of the affinity of levonorgestrel for the progesterone receptor. In contrast to levonorgestrel

“PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent

than nicotine but weaker than epibatidine in most assays, and with high affinity for both α3β4 and α4β2 subtypes, as well as the less studied α1βγδ subtype

from entering. It modulates IF2 binding to the ribosome by increasing its affinity. It may also prevent the 50S subunit from binding, stopping the formation

4R)-dimethyl-4-(3-hydroxyphenyl)piperidine antagonist scaffold which increased affinity for the nociceptin receptor by 10-fold and for the μ- and δ-opioid receptors

2% of the affinity of ORG-2058 and less than 2% of the affinity of progesterone for the PR. Similarly, it has less than 0.2% of the affinity of testosterone

Some studies also show the drug to have moderate affinity to dopamine D2 receptors and low affinity to dopamine receptor D1. Researchers are looking for

aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC, but its

gained popularity in the 1980s among musicians who found greater aesthetic affinity for acoustically based, swinging, melodic forms of jazz than for free jazz

acquired by MacroGenics. It was engineered to increase affinity for CD16A polymorphisms and decrease affinity for FcγRIIB (CD32B), an inhibitory receptor. It

reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other

R-isomer of nisoxetine has 20 times greater affinity than its S-isomer for NET. Nisoxetine has little or no affinity for neurotransmitter receptors. The NET

fairly selective for the CB1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB2(12.4nM). It was discovered by and

led to its discovery were taken from. Other isolates of the plant with affinity for opioid receptors include Pawhuskin B and Pawhuskin C, though these

structure Na+ −C≡N. It is a white, water-soluble solid. Cyanide has a high affinity for metals, which leads to the high toxicity of this salt. Its main application

some phenyltropanes with high activity and selectivity for the SERT (pM affinity). RTI-83 Troparil Tropine Tropinone Navarro HA, Xu H, Zhong D, Blough BE

people. Clarion is based in Camden and was formed in 2016 as a merger of Affinity Sutton and Circle Housing Group. Clarion Housing Group comprises the Group's

Tentaculites is an extinct genus of conical fossils of uncertain affinity, class Tentaculita, although it is not the only member of the class. It is known

receptor. The affinity of ramelteon for the MT1 and MT2 receptors is 3 to 16 times higher than that of melatonin. Ramelteon has 8-fold higher affinity for the

Fallypride is a high-affinity dopamine D2/D3 receptor antagonist used in medical research, usually in the form of fallypride (18F) as a positron emission

Franco Montoro International Airport Nacional did not have an airline affinity program. List of defunct airlines of Brazil Beting, Gianfranco. "45 anos

It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic

insomnia and other sleep disorders. Cinazepam has an order of magnitude lower affinity for the benzodiazepine receptor of the GABAA complex relative to other

variously translated as "appropriation," "orientation," "familiarization," "affinity," "affiliation," and "endearment." Oikeiôsis signifies the perception of

to these sites and have similar properties. In addition to their high affinity for the main site of the monoamine transporters, several competitive transporter

Cortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid. It is sometimes abbreviated

receptor antagonists that yielded some compounds but lacked sufficient affinity for the NK1 receptor, despite structure-activity relationship (SAR) studies

peptides with the highest binding affinity. In 1988, Stephen Parmley and George Smith described biopanning for affinity selection and demonstrated that

3-MeO-PCP and methoxetamine. 4-MeO-PCP has lower affinity for the NMDA receptor than PCP, but higher affinity than ketamine, it is orally active in a dosage

leukotriene B4 (LTB4) with far lower affinity than the BLT1 receptor does and therefore has been termed the low affinity LTB4 receptor. Sometime after its

Desmethoxyfallypride is a moderate affinity dopamine D2 receptor/D3 receptor antagonist used in medical research, usually in the form of the radiopharmaceutical

the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, where it acts as an agonist, but does not bind to the low-affinity GHB binding

non-selective muscarinic acetylcholine receptor agonist with similar high affinity for all five muscarinic acetylcholine receptor subtypes but has greater

and high-affinity ligand of the μ-, κ-, and δ-opioid receptors (Ki = 3.0, 4.7, and 15 nM in guinea pig brain membranes) with very low affinity for the

the influenza virus, showing affinity to the glycoproteins inserted in the host cell membrane on one side and affinity for the RNP complex molecules

outdated term affinity, which was used by chemists in previous years to describe the force that caused chemical reactions. The term affinity, as used in

Cortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid. It is sometimes abbreviated

residues that can form five disulphide bonds[9]. The toxin shows high affinity for the nicotinic acetylcholine receptor (nAChRs) in the postsynaptic membrane

much lower affinity for the psychoactive CB1 receptor. UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1

peptides with the highest binding affinity. In 1988, Stephen Parmley and George Smith described biopanning for affinity selection and demonstrated that

Franco Montoro International Airport Nacional did not have an airline affinity program. List of defunct airlines of Brazil Beting, Gianfranco. "45 anos

Desmethoxyfallypride is a moderate affinity dopamine D2 receptor/D3 receptor antagonist used in medical research, usually in the form of the radiopharmaceutical

and S enantiomers in binding affinity to amino acids in the M2 channel. Since the enantiomers have similar binding affinity, they also have similar ability

Good Sam Enterprises (formerly Affinity Group or AGI) is a provider of membership clubs, as well as subscription-based products, services and publications

dissociation constant (i.e., a lower affinity interaction) compared an ASGP with several sugars attached. This increased affinity in the presence of more sugars

SLC1A7 gene. EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino

Brimonidine Cannabigerol (also acts as a moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist). Clonidine (also I1 agonist)

suggest that integrins bind to talin, although with low affinity. Talin also binds with high affinity to vinculin, another cytoskeletal protein concentrated

receptor antagonists that yielded some compounds but lacked sufficient affinity for the NK1 receptor, despite structure-activity relationship (SAR) studies

explanation of these properties, norbuprenorphine has been found to be a high affinity P-glycoprotein substrate, and in accordance, shows very limited blood-brain-barrier

single individual (UA 8651 and FMNH PA715).[citation needed] The phylogenic affinity of Vorona is hard to determine due to the fragmentary nature of the remains

First opened in 1829, it closed in June 2017 when its parent company, Affinity Bars and Restaurants, became insolvent, but re-opened in November 2017

video game developed by 343 Industries, Saber Interactive, and Certain Affinity, and published by Microsoft Game Studios for the Xbox 360 console. It is

E. Nichols and colleagues at Purdue University. It has similar binding affinity to LSD itself as both a 5-HT1A and 5-HT2A agonist, and produces similar

equal affinity for D2- and D3-receptor and much lower affinity for D1-receptor. Non-ergoline dopamine receptor agonists have higher binding affinity to dopamine

defunct Pandemic Studios. 343 Industries also collaborated with Certain Affinity on Halo: Reach's second and third map packs. The company was responsible

people. Clarion is based in Camden and was formed in 2016 as a merger of Affinity Sutton and Circle Housing Group. Clarion Housing Group comprises the Group's

A nymph (Ancient Greek: νύμφη, romanized: nýmphē; Attic Greek: [nýmpʰɛː]; sometimes spelled nymphe) is a minor female nature deity in ancient Greek folklore

ambient surface conditions). Some elements have affinities to more than one phase. The main affinity is given in the table below and a discussion of each

determinations for peptide and protein identifications. Affinity proteomics uses antibodies or other affinity reagents (such as oligonucleotide-based aptamers)

proteins based on various properties, including charge, size, and binding affinity. Here are the main types of chromatography used in protein purification:

weight of around 80 kDa and contains two specific high-affinity Fe(III) binding sites. The affinity of transferrin for Fe(III) is extremely high (association

affinity for the noradrenaline transporter and 5-HT2A receptor, while retaining high serotonin transporter affinity and markedly increasing affinity for

The Allmusic review by Scott Yanow states: "This LP from the English Affinity LP is a mixed bag. Best is 'Rain Forrest' on which tenor saxophonist Archie

Virginia. Southern West Virginia has coal mining heritage and Southern affinity, including being part of the Bible Belt. The region is also closely identified

more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the

urinary excretion. 2-Hydroxyestradiol has approximately 7% and 11% of the affinity of estradiol at the estrogen receptors (ERs) ERα and ERβ, respectively

cannabinoid ligand that binds to both CB1 and CB2. It has a bindining affinity of Ki = 0.9 nM for the CB2 subtype, and more than 65 times selectivity

JWH-048 is a selective cannabinoid ligand, with a bindining affinity of Ki = 0.5 ± 0.1 nM for the CB2 subtype, and more than 22 times selectivity over

Holly Springs sand member  USA  Tennessee Named as a flower of uncertain affinity. Antholithes grablensis Species nov Berry Eocene Tallahatta Formation Holly

(R)-Willardiine Only the (S) isomer has binding affinity for the AMPA and kainate receptors. Isomer-specific binding affinity is a result of steric effects between

USR1 and USR2 show closest genetic affinity to Shuká Káa from On Your Knees Cave. USR1 shows extra genetic affinity for Siberians and East Asians in a

has reasonable selectivity for the CB2 receptor subtype, having a CB2 affinity of 0.4nM, and 25x selectivity over the related CB1 receptor. AB-FUBINACA

spectacular resemblance with Kashmiri which is not pure Kashmiri but has close affinity to the Kashmiri of the valley. So Kishtwari-Kashmiri is a dialect of Kashmiri

fairly selective for the CB1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB2(12.4nM). It was discovered by and

In biology, a pair bond is the strong affinity that develops in some species between a mating pair, often leading to the production and rearing of young

analgesic, and is a potent agonist of the CB1 receptor with a binding affinity (Ki) of 0.33 nM and an EC50 of 14.7 nM. The analogue with a 1-butyl substitution

properties, but with approximately 60-fold lower affinity for the α1-adrenergic receptor, and the weakest affinity of any of the TCAs analyzed for the muscarinic

video game developed by 343 Industries, Saber Interactive, and Certain Affinity, and published by Microsoft Game Studios for the Xbox 360 console. It is

the muscle and nonmuscle cells. TMOD is able to have high-affinity binding through low-affinity interactions because of its ability to control subunit exchange

that BGT1 is expressed at far lower levels than GAT1 and also has lower affinity for GABA. This implies that it is not likely to contribute significantly

Franco Montoro International Airport Via Brasil did not have an airline affinity program. List of defunct airlines of Brazil Brazil portal Aviation portal

nonsteroidal antiandrogen (NSAA) derived from nilutamide with very high affinity and selectivity for the androgen receptor (AR), which made it among the

championship tournament for the 2021–22 season. The tournament took place at Affinity Place in Estevan, Saskatchewan from May 18 to 29, 2022. It was the first

A nymph (Ancient Greek: νύμφη, romanized: nýmphē; Attic Greek: [nýmpʰɛː]; sometimes spelled nymphe) is a minor female nature deity in ancient Greek folklore

It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic

Company for breast cancer and prostate cancer, but was abandoned.: 11  Its affinity for the rat estrogen receptor was reported to be 20% relative to estradiol

testosterone. The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone. It is a designer

RWJ-413216, which is a potent agonist at the μ-opioid receptor and has less affinity for δ (Ki of 0.26 nM at μ, 46.7 nM at δ). The effect of RWJ-394674 when

AM-1235), as almost all commonly used CB1 agonists have similar or greater affinity for CB2 than CB1, and the only truly highly selective CB1 agonists known

acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter. Expression of SLC16A8 is confined to the retinal

encountered as a powder and in tablet form. Though diphenidine possesses higher affinity for the NMDA receptor, anecdotal reports suggest methoxphenidine has greater

the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the CB1 receptor is reported as Ki = 52 ± 5 nM. In the United

selective agonist for the δ-opioid receptor, with approximately 15× stronger affinity for the δ-opioid than the μ-opioid receptor. It has potent analgesic and

a high-affinity receptor (FcεRI) for the Fc region of IgE, the least-abundant member of the antibodies. This receptor is of such high affinity that binding

dissociation constant (i.e., a lower affinity interaction) compared an ASGP with several sugars attached. This increased affinity in the presence of more sugars

compound JWH-175, and the carbonyl reduced analog of JWH-007. The binding affinity of JWH-196 for the CB1 receptor is reported as Ki = 151 ± 18 nM. In the

the carbonyl-reduced derivative of related compound JWH-122. The binding affinity of JWH-184 for the CB1 receptor is reported as Ki = 23 ± 6 nM. In the United

acetate, which is marketed as a progestin. Nomegestrol shows relatively low affinity for the progesterone receptor, only about 4% of that of progesterone and

Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the distance measures time from

which acts as a selective μ-opioid receptor agonist, with little or no affinity for the δ-opioid or κ-opioid receptors. It is an active analgesic in vivo

lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils. Talizumab was tested in clinical

the carbonyl-reduced derivative of related compound JWH-081. The binding affinity of JWH-185 for the CB1 receptor is reported as Ki = 17 ± 3 nM. In the United

restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB1 and CB2 receptors. It is a potent and reasonably

weight of around 80 kDa and contains two specific high-affinity Fe(III) binding sites. The affinity of transferrin for Fe(III) is extremely high (association

microbes able to respire oxygen "within microoxic environments by using high-affinity terminal oxidase". Microaerophiles are traditionally cultivated in candle

receptor. It is similar to N6-cyclopentyladenosine. Due to CCPA's high affinity for Adenosine A1 receptors, its tritiated derivative [3H]CCPA can be used

"selective affinity", meaning that the inner surface of the ectoderm has a strong (positive) affinity for the mesoderm, and a weak (negative) affinity for the

non-covalent binding by repeated doses of agonists with extremely high binding affinity such as lofentanil. Chlornaltrexamine, an irreversible mixed μ-opioid agonist-antagonist

reasonably highly selective CB2 agonist, but still retains appreciable affinity at CB1, with a Ki of 0.088nM at CB2 vs 11nM at CB1. JTE 7-31 is illegal

are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as

interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is

has reasonable selectivity for the CB2 receptor subtype, having a CB2 affinity of 0.4nM, and 25x selectivity over the related CB1 receptor. AB-FUBINACA

ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A2A receptor. In animal models, ZM-241,385 has been shown to protect against

proteins based on various properties, including charge, size, and binding affinity. Here are the main types of chromatography used in protein purification:

are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as

the muscle and nonmuscle cells. TMOD is able to have high-affinity binding through low-affinity interactions because of its ability to control subunit exchange

testosterone. The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone. It is a designer

"selective affinity", meaning that the inner surface of the ectoderm has a strong (positive) affinity for the mesoderm, and a weak (negative) affinity for the

shows higher affinity for the AR, with approximately 27% of the affinity of metribolone. However, although 5α-DHNET has higher affinity for the AR than

In biology, a pair bond is the strong affinity that develops in some species between a mating pair, often leading to the production and rearing of young

has reasonable selectivity for the CB2 receptor subtype, having a CB2 affinity of 0.4nM, and 25x selectivity over the related CB1 receptor. AB-FUBINACA

acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter. Expression of SLC16A8 is confined to the retinal

lymphoid tissue. The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll-like receptors

the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the CB1 receptor is reported as Ki = 52 ± 5 nM. In the United

translated as "destiny, luck as conditioned by one's past", or "natural affinity among friends." It is comparable to the concept of karma in Buddhism, but

nonselective antagonist of the opioid receptors, albeit with somewhat low affinity. Shiota, S; Shimizu, M; Mizushima, T; Ito, H; Hatano, T; Yoshida, T; Tsuchiya

compound JWH-175, and the carbonyl reduced analog of JWH-007. The binding affinity of JWH-196 for the CB1 receptor is reported as Ki = 151 ± 18 nM. In the

the carbonyl-reduced derivative of related compound JWH-122. The binding affinity of JWH-184 for the CB1 receptor is reported as Ki = 23 ± 6 nM. In the United

is a moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 14.0 ± 1.0 nM at this subtype, and more than eight times selectivity

language sub-group called Raji-Raute. This language sub-group shows some affinity to areal Mahakiranti group Himalayish languages such as Kham Magar and

estrogen which was never marketed. It has about 86% of the relative binding affinity of estradiol for the estrogen receptor. 11β-MeOE2 is structurally related

appreciation only in a narrow circle of intimate friends. Poetry with its close affinity to music brought about a successful team-effort between poet Momčilo Nastasijević

components also takes place in column chromatography by a difference in affinity between stationary phase and the mobile phase. In fractional crystallization

the mu-, kappa-, and delta-opioid receptors; it has the highest binding affinity for the kappa-opioid receptor. Structures of dynorphin A bound to the κ-opioid

estrogen receptor modulator (SERM) zindoxifene (D-16726). D-15414 has high affinity for the estrogen receptor (ER) and inhibits the growth of ER-positive MCF-7

to find target proteins with desired properties and can be used to make affinity ligands which are cell-specific. This system can be used in many applications

the biological target of progestogens like progesterone. It has some affinity for the glucocorticoid receptor and has no other important hormonal activity

major active metabolite of the opioid modulator buprenorphine. It has affinity for the κ-opioid receptor (Ki = 300 nM) and the nociceptin receptor (Ki

Japan and certain Southeast Asian countries as of 2008. It has higher affinity for the 5-HT3 receptor than the older 5-HT3 antagonists, and maintains

Hemorphin-4 has affinities for the μ-, δ-, and κ-opioid receptors that are in the same range as the structurally related β-casomorphins, although affinity to the

neurotransmission in the brain and has a higher affinity for the dopamine transporter than cocaine, but has a lower affinity for the serotonin and norepinephrine

Tocantins, and to Cayenne in French Guiana. Penta did not have an airline affinity program. 26 April 1994: a Cessna 208A Caravan registration PT-OGI flying

pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 receptor of 6 nM, binding around seven times more tightly than

frogs native to South and Central America. Deltorphin possesses very high affinity and selectivity as an agonist for the δ-opioid receptor, and on account

endomorphins. It has the amino acid sequence Tyr-Pro-Phe-Phe-NH2. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1

beta blocker. ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. The

only moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 0.73 ± 0.03 nM at this subtype, and more than six times selectivity

with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of phosphate anions. Unlike P-type ATPases, it does not undergo

He travelled to almost every corner of the Valley and developed a close affinity with the people who figure prominently in the work. The book describes

the estrogenic activity of trestolone. The compound shows about higher affinity for the androgen receptor than estradiol. List of estrogens Methylestradiol

ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A2A receptor. In animal models, ZM-241,385 has been shown to protect against

substantially reducing NET affinity. This compound has been called "mazindane". Removal of the p-chlorine atom increases NET affinity and substantially reduces

of affinity. Affinity is an advanced form of mental communication similar to the present-day concepts of telepathy or entanglement. Edenist affinity allows

activity and the structural specificity of PCFT (high affinity for folic acid, and low affinity for PT523 - a non-polyglutamable analog of aminopterin)

Gene ontology Molecular function high-affinity lysine transmembrane transporter activity low-affinity L-arginine transmembrane transporter activity L-arginine

Emopamil is a calcium channel blocker and a high-affinity ligand of human sterol isomerase. Emopamil's structure consists of an organic amino compound

CB2 receptor, but a weaker ligand for the CB1 receptor. It has a binding affinity of Ki = 6.1 ± 0.7 nM at the CB2 subtype and 173 times selectivity over

affinity to D2 but is a weaker partial agonist at 5-HT2A, while the (R) enantiomer (+)-OSU-6162 has higher efficacy at 5-HT2A but lower D2 affinity.

agonist of the κ-opioid receptor (KOR), whereas it has relatively low affinity for the δ-opioid receptor (DOR) and sigma receptors. Nalbuphine was patented

Japan and certain Southeast Asian countries as of 2008. It has higher affinity for the 5-HT3 receptor than the older 5-HT3 antagonists, and maintains

neurotransmission in the brain and has a higher affinity for the dopamine transporter than cocaine, but has a lower affinity for the serotonin and norepinephrine

Tocantins, and to Cayenne in French Guiana. Penta did not have an airline affinity program. 26 April 1994: a Cessna 208A Caravan registration PT-OGI flying

into structural heterogeneity of chaperones, folding intermediates and affinity of chaperones for unstructured and structured protein chains. Many chaperones

the C14α and C17α positions. The drug has 40% of the relative binding affinity of estradiol for the human ERα. It showed an absolute bioavailability of

Mais Linhas Aéreas S/A was an airline based in Rio de Janeiro, Brazil, founded in 2010. It was authorized to operate domestic regular and non-regular flights

endomorphins. It has the amino acid sequence Tyr-Pro-Phe-Phe-NH2. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1

the mu-, kappa-, and delta-opioid receptors; it has the highest binding affinity for the kappa-opioid receptor. Structures of dynorphin A bound to the κ-opioid

with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of phosphate anions. Unlike P-type ATPases, it does not undergo

He travelled to almost every corner of the Valley and developed a close affinity with the people who figure prominently in the work. The book describes

the estrogenic activity of trestolone. The compound shows about higher affinity for the androgen receptor than estradiol. List of estrogens Methylestradiol

substantially reducing NET affinity. This compound has been called "mazindane". Removal of the p-chlorine atom increases NET affinity and substantially reduces

of affinity. Affinity is an advanced form of mental communication similar to the present-day concepts of telepathy or entanglement. Edenist affinity allows

activity and the structural specificity of PCFT (high affinity for folic acid, and low affinity for PT523 - a non-polyglutamable analog of aminopterin)

that has been used as a radioligand in PET studies. It possesses modest affinity for the 5-HT7 (Ki = 9.1 nM) and D4 (Ki = 8.5 nM) receptors, although the

CB2 receptor, but a weaker ligand for the CB1 receptor. It has a binding affinity of Ki = 6.1 ± 0.7 nM at the CB2 subtype and 173 times selectivity over

ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ. It has approximately 3% and 7% of the affinity of estradiol at the ERα

superfamily containing two subtypes, NPFF1 and NPFF2, which exhibit a high affinity for Neuropeptide FF (NPFF) peptides. NPFF1 is broadly distributed in the

appropriate for export of lactate derived from glycolysis. MCT4 exhibits a lower affinity for most substrates and inhibitors than MCT1, with Km and Ki values some

shown ABT-089 to be effective for this application. It binds with high affinity subtype-selective to the α4β2 nicotinic acetylcholine receptors and has

never marketed. It also has moderate affinity for the muscarinic acetylcholine receptors and weak/negligible affinity for the α1-adrenergic, 5-HT2A, D1,

It acts as an HIV protease inhibitor and binds to this target with high affinity, however despite promising results in early testing, mozenavir was unsuccessful

thought to be the reason for the binding affinity to the AChRs. The exact reason for the especially high binding affinity of toxiferine to for example muscle-type

phenylacetylindole family, which acts as a cannabinoid agonist with moderate affinity at both the CB1 and CB2 receptors. It is a positional isomer of the more

pre-Socratic philosophy into the Ionian and Italian school. The collective affinity of the Ionians was first acknowledged by Aristotle who called them physiologoi

studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant

first synthesised by Daniel Trachsel some years later. It has a binding affinity of 11nM at 5-HT2A and 40nM at 5-HT2C. It is reportedly a potent psychedelic

gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the hERG channel. Imidazopyridine Mikami T, Ochi Y, Suzuki K, Saito

result in the loss of CNGB3 function or gain of function—often increased affinity for cGMP—of CNGA3. cGMP levels are controlled by the activity of the cone

Early molecular data placed Breviata in the Amoebozoa, but without obvious affinity to known amoebozoan groups. More recently, phylogenomic analysis has shown

whether or not the enzyme has already bound the substrate but has a greater affinity for one state or the other. It is called "mixed" because it can be seen

drug, but with quite different actions from most benzodiazepines, lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist.

assays of the ERα relative to the ERβ and 70-fold preference in binding affinity for the ERα over the ERβ. In rodents, 16α-LE2 has no effect on ovarian

February 25, 2021. "Certain Affinity Reveals Ongoing Partnership with 343 Industries on Halo Infinite". Certain Affinity. August 26, 2020. Archived from

small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points

quantitative structure–activity relationships (QSAR). A related term is structure affinity relationship (SAFIR). The large number of synthetic organic chemicals currently

allow it to serve a different set of functions. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized

to CB1 and CB2 receptors with low nanomolar affinity. NM-2201 acts as a full agonist with a binding affinity of 0.332 nM at CB1 and 0.732 nM at CB2 cannabinoid

therapeutic and research capacities. Engineering zinc fingers to have an affinity for a specific sequence is an area of active research, and zinc finger

(mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affinity for beta1 receptors than metoprolol. In addition to its effect on the heart

"Heaven" affinity, the "Heaven" affinity is effective against the "Earth" affinity, and the "Earth" affinity is effective against the "Man" affinity. Dynasty

WAY-166989) is an investigational nonsteroidal progestin. It is a high affinity, high efficacy, and very selective agonist of the progesterone receptor

receptor inverse agonist developed by GlaxoSmithKline. It has subnanomolar affinity for the H3 receptor (Ki = 0.2nM) and selectivity of over 10,000x for H3

form of tamoxifen in the body. In one study, N-desmethyltamoxifen had an affinity for the estrogen receptor of 2.4% relative to estradiol. For comparison

Buspirone acts as a partial agonist of the serotonin 5-HT1A receptor with high affinity. It is a partial agonist of both presynaptic 5-HT1A receptors, which are

neurodegenerative diseases continued and focused on developing low affinity blockers. However the affinity could not be too low and dwell time not too short (as seen