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searching for Allosteric regulation 50 found (163 total)

Metabolic intermediate (128 words) [view diff] exact match in snippet view article find links to article

importance to cellular function, they can play important roles in the allosteric regulation of enzymes. Some can be useful in measuring rates of metabolic processes

Ruth Nussinov (1,987 words) [view diff] exact match in snippet view article find links to article

mechanism of recognition and posited that population shift underlies allosteric regulation. The concept of dynamic energy landscape that she introduced tacitly

Pseudoenzyme (1,384 words) [view diff] exact match in snippet view article find links to article

PMID 12377129. Willert EK, Fitzpatrick R, Phillips MA (May 2007). "Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically

Stuart J. Edelstein (576 words) [view diff] exact match in snippet view article find links to article

leading to sickle-cell disease. He then turned his attention on the allosteric regulation of neurotransmitter receptors, in particular the nicotinic acetylcholine

Stephen J. Benkovic (3,234 words) [view diff] exact match in snippet view article find links to article

Science 322, 438-442. Goodey, N. M. and Benkovic, S. J. (2008) Allosteric regulation and catalysis emerge via a common route, Nat. Chem. Biol. 4, 474-482

NAS Award in the Neurosciences (442 words) [view diff] exact match in snippet view article find links to article

that fast-acting neurotransmitters mediate their effects through allosteric regulation of the neurotransmitter protein. Brenda Milner (2004) For her pioneering

GYKI 52466 (336 words) [view diff] exact match in snippet view article find links to article

function Tifluadom Lufuradom Donevan, S.D; Rogawski, M.A (1998). "Allosteric regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors by

Cyclic nucleotide phosphodiesterase (821 words) [view diff] exact match in snippet view article find links to article

"Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 5 (2): eaav4322

Glucose cycle (366 words) [view diff] exact match in snippet view article find links to article

regulated by several hormones including insulin and glucagon as well as allosteric regulation of both hexokinase and glucose 6-phosphatase. A deficiency in glucose

PDE6B (2,159 words) [view diff] exact match in snippet view article find links to article

"Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 27 (5): eaav4322

Rab escort protein 1 (1,240 words) [view diff] exact match in snippet view article find links to article

Iakovenko A, Kalinin A, Waldmann H, Goody RS, Alexandrov K (2001). "Allosteric regulation of substrate binding and product release in geranylgeranyltransferase

HCN channel (1,554 words) [view diff] case mismatch in snippet view article find links to article

William N.; Stoll, Stefan (2016-01-01). "Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides". Journal of Biological

Cytoglobin (1,142 words) [view diff] exact match in snippet view article find links to article

Hundahl C, Dewilde S, Gilany K, Moens L, Weber RE (Oct 2004). "Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin

PANK1 (453 words) [view diff] exact match in snippet view article find links to article

"Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol.

Xiaowei Zhuang (1,592 words) [view diff] exact match in snippet view article find links to article

Deindl, S; Harada, BT; Zhuang, X (2014). "Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA". Nature. 512 (7513): 213–217

Ryanodine receptor (2,290 words) [view diff] exact match in snippet view article find links to article

megadaltons, and their structural complexity enables a wide variety of allosteric regulation mechanisms. RyR1 cryo-EM structure revealed a large cytosolic assembly

PDE6A (677 words) [view diff] exact match in snippet view article find links to article

"Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 27 (5): eaav4322

Epimerox (681 words) [view diff] exact match in snippet view article find links to article

Fischetti VA; Stebbins CE. (2008). "A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases". EMBO Rep. 9 (2): 199–205

Metabolic pathway (2,988 words) [view diff] exact match in snippet view article find links to article

chemical bond, whereas a non-covalent modification (also known as allosteric regulation) is the binding of the regulator to the enzyme via hydrogen bonds

PDE6G (968 words) [view diff] exact match in snippet view article find links to article

"Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 5 (2): eaav4322

Alpha beta barrel (256 words) [view diff] exact match in snippet view article find links to article

Herman, P. (2011). Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase. Methods in Enzymology. Vol. 488. pp. 185–217

Amino acid synthesis (3,929 words) [view diff] exact match in snippet view article find links to article

threonine synthase. The biosynthesis of threonine is regulated via allosteric regulation of its precursor, homoserine, by structurally altering the enzyme

PPP1R14A (1,258 words) [view diff] exact match in snippet view article find links to article

2004). "Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits". Proceedings of

Douglas C. Rees (561 words) [view diff] exact match in snippet view article find links to article

high-affinity E. coli methionine ABC transporter: structure and allosteric regulation, Science, volume 321, 2008, pp. 250–253 with E. Johnson, O. Lewinson:

Lidia Mannuzzu (792 words) [view diff] exact match in snippet view article find links to article

sensors. Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Roland Schönherr

HK1 (3,048 words) [view diff] exact match in snippet view article find links to article

multiple ADP binding sites and conformational changes relevant to allosteric regulation". Journal of Molecular Biology. 296 (4): 1001–1015. doi:10.1006/jmbi

Citric acid cycle (6,045 words) [view diff] exact match in snippet view article find links to article

metabolic reprogramming, cell growth, and migration.[citation needed] Allosteric regulation by metabolites. The regulation of the citric acid cycle is largely

Tom McLeish (1,288 words) [view diff] case mismatch in snippet view article find links to article

Cann, Martin J. (2015). "The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein". Journal of

Baek Sung-hee (1,090 words) [view diff] exact match in snippet view article find links to article

Rose, David W.; Rosenfeld, Michael G. (2006). "Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer

GRE Biochemistry, Cell and Molecular Biology Test (835 words) [view diff] exact match in snippet view article find links to article

and Integration of Metabolism Covalent modification of enzymes Allosteric regulation Compartmentalization Hormones G Methods Biophysical approaches (e

Zacharias Dische (1,273 words) [view diff] exact match in snippet view article find links to article

11.013. PMID 33285219. S2CID 227948364. Stadtman, E.R. (1966). "Allosteric regulation of enzyme activity". Advances in Enzymology and Related Areas of

Max Perutz (3,168 words) [view diff] case mismatch in snippet view article find links to article

Jenkins. ISBN 0-7126-2123-7 1990. Mechanisms of Cooperativity and Allosteric Regulation in Proteins. Cambridge. Cambridge University Press ISBN 0-521-38648-9

Monoamine transporter (2,340 words) [view diff] exact match in snippet view article find links to article

(2019). "Monoamine transporters: structure, intrinsic dynamics and allosteric regulation". Nat. Struct. Mol. Biol. 26 (7): 545–556. doi:10.1038/s41594-019-0253-7

NT5C3 (1,670 words) [view diff] exact match in snippet view article find links to article

structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition". The Journal of Biological Chemistry

5-HT1A receptor (6,122 words) [view diff] exact match in snippet view article find links to article

PMID 19781522. Thomas EA, Carson MJ, Neal MJ, Sutcliffe JG (1997). "Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by

Adenosine A2A receptor (5,102 words) [view diff] exact match in snippet view article find links to article

P, Xu F, Katritch V, et al. (July 2012). "Structural basis for allosteric regulation of GPCRs by sodium ions". Science. 337 (6091): 232–6. Bibcode:2012Sci

David J. Galton (1,027 words) [view diff] exact match in snippet view article find links to article

and genotype levels: His group identified the earliest loss of an allosteric regulation of a rate-determining enzyme, phosphofructokinase by citrate in

Glycolysis (8,782 words) [view diff] exact match in snippet view article find links to article

Fortin R, Speranza ML, Galizzi A, Mattevi A (June 2000). "The allosteric regulation of pyruvate kinase". The Journal of Biological Chemistry. 275 (24):

USP11 (1,227 words) [view diff] exact match in snippet view article find links to article

USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase". Molecular Cell. 44 (1): 147–59. doi:10.1016/j

PTPN1 (2,731 words) [view diff] exact match in snippet view article find links to article

Phosphorylation of the Ser50 residue has also been shown as a point of allosteric regulation of PTP1B, in which the phosphorylated state of the enzyme is inactive

Calcium:cation antiporter (1,664 words) [view diff] case mismatch in snippet view article find links to article

Moshe; Khananshvili, Daniel (2013-01-01). "Molecular Determinants of Allosteric Regulation in NCX Proteins". Sodium Calcium Exchange: A Growing Spectrum of

PKM2 (4,865 words) [view diff] exact match in snippet view article find links to article

AD (July 2005). "Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis". Biochemistry. 44 (27): 9417–29. doi:10.1021/bi0474923

William Lipscomb (5,912 words) [view diff] exact match in snippet view article find links to article

Braus, G.; Lipscomb, W.N. (1997). "Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures". Structure.

EIF4E (8,380 words) [view diff] exact match in snippet view article find links to article

Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide 2gpq: Cap-free structure of eIF4E suggests basis for its allosteric regulation

Non-catalytic tyrosine-phosphorylated receptor (2,445 words) [view diff] exact match in snippet view article find links to article

PMID 21525931. Feng C, Post CB (February 2016). "Insights into the allosteric regulation of Syk association with receptor ITAM, a multi-state equilibrium"

Tumor hypoxia (5,517 words) [view diff] exact match in snippet view article find links to article

flux converting fructose-6-phosphate to fructose-1,6-bisphosphate. Allosteric regulation of glycolysis by fructose-2,6-bisphosphate allows cancer cells to

ABC transporter (14,398 words) [view diff] exact match in snippet view article find links to article

high-affinity E. coli methionine ABC transporter: structure and allosteric regulation". Science. 321 (5886): 250–3. Bibcode:2008Sci...321..250K. doi:10

ERAP1 (4,773 words) [view diff] exact match in snippet view article find links to article

linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism". Nature Communications. 12 (1): 5302. Bibcode:2021NatCo

Catch bond (5,492 words) [view diff] case mismatch in snippet view article find links to article

Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation". The Journal of Biological Chemistry. 283 (17): 11596–11605. doi:10

Pharmacology of bicalutamide (20,443 words) [view diff] exact match in snippet view article find links to article

D, Chen C, Sawyers CL, et al. (February 2006). "Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer