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searching for journal of Neuroimmunology 89 found (92 total)

alternate case: Journal of Neuroimmunology

Chronic inflammatory demyelinating polyneuropathy (5,008 words) [view diff] exact match in snippet view article find links to article

in the etiopathogenesis of peripheral demyelinating diseases". Journal of Neuroimmunology. 58 (1). Elsevier BV: 37–42. doi:10.1016/0165-5728(94)00185-q

Substance P (5,493 words) [view diff] exact match in snippet view article find links to article

neuropeptides. Stimulation of interleukin-2 production by substance p". Journal of Neuroimmunology. 37 (1–2): 65–74. doi:10.1016/0165-5728(92)90156-f. PMID 1372331

Neural top–down control of physiology (3,278 words) [view diff] exact match in snippet view article find links to article

immune-privileged site requires an intact sympathetic nervous system". Journal of Neuroimmunology. 153 (1–2): 40–49. doi:10.1016/j.jneuroim.2004.04.008. PMID 15265662

Stiff-person syndrome (2,949 words) [view diff] exact match in snippet view article find links to article

immunological basis for treatment of stiff person syndrome". Journal of Neuroimmunology. 231 (1–2): 55–60. doi:10.1016/j.jneuroim.2010.09.014. PMID 20943276

Neuroinflammation (5,084 words) [view diff] exact match in snippet view article find links to article

sclerosis patients suggest an ongoing neuroinflammatory process". Journal of Neuroimmunology. 210 (1–2): 73–79. doi:10.1016/j.jneuroim.2009.02.012. PMID 19307024

Anti-IgLON5 disease (1,094 words) [view diff] exact match in snippet view article find links to article

with autoantibodies to IgLON5 and responsive to immunotherapy". Journal of Neuroimmunology. 300: 9–10. doi:10.1016/j.jneuroim.2016.09.012. PMID 27806876

John A. Pollock (professor) (3,586 words) [view diff] exact match in snippet view article

via targeted nanoemulsion delivery to neuroinflammation in rat. Journal of Neuroimmunology, 318, 72–79. D. J. Lampe, B. Kantorski, J. A. Pollock (2018) Charles

CCL2 (2,419 words) [view diff] exact match in snippet view article find links to article

(July 2010). "The emerging role for chemokines in epilepsy". Journal of Neuroimmunology. 224 (1–2): 22–7. doi:10.1016/j.jneuroim.2010.05.016. PMID 20542576

BRSK2 (493 words) [view diff] exact match in snippet view article find links to article

2: a new autoantigen in paraneoplastic limbic encephalitis". Journal of Neuroimmunology. 170 (1–2): 186–90. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222

SOCS7 (642 words) [view diff] exact match in snippet view article find links to article

leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology. 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179

McDonald criteria (2,179 words) [view diff] exact match in snippet view article find links to article

fluid in the diagnosis and monitoring of multiple sclerosis". Journal of Neuroimmunology. 219 (1–2): 1–7. doi:10.1016/j.jneuroim.2009.09.002. PMID 19782408

FOSL2 (676 words) [view diff] exact match in snippet view article find links to article

requires both constitutive and inducible transcription factors". Journal of Neuroimmunology. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367

MMP10 (1,134 words) [view diff] exact match in snippet view article find links to article

tumor necrosis factor and multiple sclerosis: an overview". Journal of Neuroimmunology. 72 (2): 155–61. doi:10.1016/S0165-5728(96)00179-8. PMID 9042108

CCL1 (1,363 words) [view diff] exact match in snippet view article find links to article

expression in murine experimental allergic encephalomyelitis". Journal of Neuroimmunology. 58 (2): 167–76. doi:10.1016/0165-5728(95)00008-p. PMID 7539012

Torisashi (153 words) [view diff] exact match in snippet view article find links to article

encephalitis after an outbreak of Campylobacter jejuni enteritis". Journal of Neuroimmunology. 196 (1–2): 143–146. doi:10.1016/j.jneuroim.2008.02.011. PMID 18406474

Tachykinin receptor 2 (1,178 words) [view diff] exact match in snippet view article find links to article

regulation: cloning and characterization of neurokinin-2 promoter". Journal of Neuroimmunology. 138 (1–2): 65–75. doi:10.1016/S0165-5728(03)00096-1. PMID 12742655

Acanthocystis turfacea chlorella virus 1 (393 words) [view diff] exact match in snippet view article find links to article

of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice". Journal of Neuroimmunology. 297: 46–55. doi:10.1016/j.jneuroim.2016.05.009. PMID 27397075

FCGR3B (1,186 words) [view diff] exact match in snippet view article find links to article

RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS". Journal of Neuroimmunology. 140 (1–2): 210–5. doi:10.1016/S0165-5728(03)00207-8. PMID 12864991

CXCR6 (1,171 words) [view diff] exact match in snippet view article find links to article

cells: CXCR6 is a marker of IFNgamma-producing effector cells". Journal of Neuroimmunology. 127 (1–2): 96–105. doi:10.1016/S0165-5728(02)00106-6. PMID 12044980

Biomarkers of multiple sclerosis (7,797 words) [view diff] exact match in snippet view article find links to article

of interferon beta response in multiple sclerosis patients". Journal of Neuroimmunology. 291: 73–77. doi:10.1016/j.jneuroim.2015.12.015. PMID 26857498

Immunoglobulin light chain (1,236 words) [view diff] exact match in snippet view article find links to article

antigen-specific responses of murine dorsal root ganglion neurons". Journal of Neuroimmunology. 208 (1–2): 80–86. doi:10.1016/j.jneuroim.2009.01.008. PMID 19232443

Solute carrier organic anion transporter family member 2A1 (682 words) [view diff] exact match in snippet view article find links to article

transporter in Alzheimer disease brains and age-matched controls". Journal of Neuroimmunology. 195 (1–2): 81–7. doi:10.1016/j.jneuroim.2008.01.014. PMC 2365511

Vesicular acetylcholine transporter (823 words) [view diff] exact match in snippet view article find links to article

of cholinergic markers in human peripheral blood lymphocytes". Journal of Neuroimmunology. 132 (1–2): 147–55. doi:10.1016/s0165-5728(02)00325-9. PMID 12417445

Prazosin (1,776 words) [view diff] exact match in snippet view article find links to article

of patients with polyarticular juvenile rheumatoid arthritis". Journal of Neuroimmunology. 71 (1–2): 223–226. doi:10.1016/s0165-5728(96)00125-7. PMID 8982123

Alpha-enolase (1,937 words) [view diff] exact match in snippet view article find links to article

amino terminal of alpha-enolase in Hashimoto's encephalopathy". Journal of Neuroimmunology. 185 (1–2): 195–200. doi:10.1016/j.jneuroim.2007.01.018. PMID 17335908

Interleukin 1 receptor, type II (1,414 words) [view diff] exact match in snippet view article find links to article

a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology. 70 (2): 113–122. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719

CISH (protein) (1,432 words) [view diff] exact match in snippet view article

leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology. 109 (1): 34–39. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179

Lymphocyte-activation gene 3 (6,133 words) [view diff] exact match in snippet view article find links to article

genes in multiple sclerosis in two independent populations". Journal of Neuroimmunology. 180 (1–2): 193–8. doi:10.1016/j.jneuroim.2006.08.009. PMID 17020785

Shiga toxin (2,313 words) [view diff] exact match in snippet view article find links to article

receptor globotriaosylceramide and causes dendritic abnormalities". Journal of Neuroimmunology. 222 (1–2): 48–61. doi:10.1016/j.jneuroim.2010.03.001. hdl:11336/16303

Theiler's encephalomyelitis virus (1,153 words) [view diff] exact match in snippet view article find links to article

environment of the Theiler's virus model of multiple sclerosis, Journal of Neuroimmunology, Volume 144, Issues 1–2, November 2003, Pages 68-79, doi: https://doi

Experimental autoimmune encephalomyelitis (2,134 words) [view diff] exact match in snippet view article find links to article

environment of the Theiler's virus model of multiple sclerosis". Journal of Neuroimmunology. 144 (1–2): 68–79. doi:10.1016/j.jneuroim.2003.08.032. PMID 14597100

Tachykinin receptor 1 (2,636 words) [view diff] exact match in snippet view article find links to article

2004). "Substance P and neurokinin-1 receptor modulation of HIV". Journal of Neuroimmunology. 157 (1–2): 48–55. doi:10.1016/j.jneuroim.2004.08.022. PMID 15579279

Co-receptor (3,129 words) [view diff] exact match in snippet view article find links to article

A. (2010). ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex. Journal of Neuroimmunology, 226, 93-103.

Enolase (3,254 words) [view diff] exact match in snippet view article find links to article

are a useful diagnostic marker of Hashimoto's encephalopathy". Journal of Neuroimmunology. 162 (1–2): 130–136. doi:10.1016/j.jneuroim.2005.02.004. PMID 15833368

Pathophysiology of multiple sclerosis (9,040 words) [view diff] exact match in snippet view article find links to article

sclerosis patients support neuro-antigen-specific Th17 responses". Journal of Neuroimmunology. 291: 46–53. doi:10.1016/j.jneuroim.2015.11.022. PMID 26857494

MTCH1 (1,039 words) [view diff] exact match in snippet view article find links to article

carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease". Journal of Neuroimmunology. 263 (1–2): 139–44. doi:10.1016/j.jneuroim.2013.08.007. hdl:11693/12552

Suniti Solomon (1,350 words) [view diff] exact match in snippet view article find links to article

"Neurological manifestations in aids patients in South India". Journal of Neuroimmunology. 63 (1): 100. doi:10.1016/0165-5728(96)80989-1. S2CID 53181197

Ruth Arnon (1,563 words) [view diff] exact match in snippet view article find links to article

in normal development induced by immunomodulatory treatment". Journal of Neuroimmunology. 275 (1–2): 213–214. doi:10.1016/j.jneuroim.2014.08.573. S2CID 53189444

CXCR5 (1,849 words) [view diff] exact match in snippet view article find links to article

chemokine receptor expression in human microglia and astrocytes". Journal of Neuroimmunology. 136 (1–2): 84–93. doi:10.1016/S0165-5728(03)00009-2. PMID 12620646

Oligoclonal band (2,556 words) [view diff] exact match in snippet view article find links to article

diseases presenting as oligoclonal bands in cerebrospinal fluid". Journal of Neuroimmunology. 237 (1–2): 93–7. doi:10.1016/j.jneuroim.2011.06.012. PMID 21767883

Interferon type I (2,932 words) [view diff] exact match in snippet view article find links to article

interaction with opioid receptor inducing prostaglandin E2". Journal of Neuroimmunology. 156 (1–2): 107–112. doi:10.1016/j.jneuroim.2004.07.013. PMID 15465601

SPTAN1 (2,717 words) [view diff] exact match in snippet view article find links to article

analysis of cerebrospinal fluid in Guillain–Barré syndrome (GBS)". Journal of Neuroimmunology. 185 (1–2): 190–4. doi:10.1016/j.jneuroim.2007.01.022. PMID 17367871

Glial fibrillary acidic protein (3,301 words) [view diff] exact match in snippet view article find links to article

Leydig cells of the Syrian golden hamster (Mesocricetus auratus)". Journal of Neuroimmunology. 35 (1–3): 119–129. doi:10.1016/0165-5728(91)90167-6. PMID 1720132

CLEC16A (1,269 words) [view diff] exact match in snippet view article find links to article

provides evidence of allelic heterogeneity at the IL2RA locus". Journal of Neuroimmunology. 211 (1–2): 105–9. doi:10.1016/j.jneuroim.2009.03.010. PMID 19375175

Interleukin 26 (2,809 words) [view diff] exact match in snippet view article find links to article

in multiple sclerosis patients under interferon β-1 therapy". Journal of Neuroimmunology. 255 (1–2): 81–4. doi:10.1016/j.jneuroim.2012.10.009. PMID 23177721

Fingolimod (2,574 words) [view diff] exact match in snippet view article find links to article

function independently of the sphingosine-1-phosphate pathway". Journal of Neuroimmunology. 270 (1–2): 13–21. doi:10.1016/j.jneuroim.2014.03.007. PMID 24680062

Chlorovirus (3,491 words) [view diff] exact match in snippet view article find links to article

of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice". Journal of Neuroimmunology. 297: 46–55. doi:10.1016/j.jneuroim.2016.05.009. PMID 27397075

CD97 (3,290 words) [view diff] exact match in snippet view article find links to article

receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". Journal of Neuroimmunology. 132 (1–2): 156–63. doi:10.1016/s0165-5728(02)00306-5. PMID 12417446

Vijendra K. Singh (1,308 words) [view diff] exact match in snippet view article find links to article

interleukin-12 and interferon-gamma. Pathological significance in autism". Journal of Neuroimmunology. 66 (1–2): 143–145. doi:10.1016/0165-5728(96)00014-8. PMID 8964908

Robyn S. Klein (2,672 words) [view diff] exact match in snippet view article find links to article

Yang L, Hamilton SL, Heffernan JR, Hou J, Miller MJ, Klein RS. Journal of Neuroimmunology. 2017 Jul 15;308:118-130. Speaking out about gender imbalance

Chemokine (2,931 words) [view diff] exact match in snippet view article find links to article

Mélik-Parsadaniantz S, Rostène W (July 2008). "Chemokines and neuromodulation". Journal of Neuroimmunology. 198 (1–2): 62–8. doi:10.1016/j.jneuroim.2008.04.022. PMID 18538863

Multiple sclerosis drug pipeline (9,405 words) [view diff] exact match in snippet view article find links to article

autoimmune encephalomyelitis: implications for multiple sclerosis". Journal of Neuroimmunology. 149 (1–2): 84–9. doi:10.1016/j.jneuroim.2003.12.015. PMID 15020068

Toll-like receptor 4 (9,082 words) [view diff] exact match in snippet view article find links to article

receptors: emerging therapeutics for multiple sclerosis management". Journal of Neuroimmunology. 239 (1–2): 1–12. doi:10.1016/j.jneuroim.2011.08.010. PMID 21889214

NAV2 (1,248 words) [view diff] exact match in snippet view article find links to article

gene with the risk and age at onset of Alzheimer's disease". Journal of Neuroimmunology. 310: 60–65. doi:10.1016/j.jneuroim.2017.06.010. ISSN 0165-5728

Glutamic acid (3,237 words) [view diff] exact match in snippet view article find links to article

Person Syndrome Spectrum Disorders; More Than Meets the Eye". Journal of Neuroimmunology. 369: 577915. doi:10.1016/j.jneuroim.2022.577915. ISSN 0165-5728

Immunosignature (1,883 words) [view diff] exact match in snippet view article find links to article

immunosignature diagnostic test", doi:10.1016/j.jneuroim.2012.09.014, Journal of Neuroimmunology, 2012. Sykes K., Legutki JB, Stratford P. "Immunosignaturing:

NK1 receptor antagonist (3,286 words) [view diff] exact match in snippet view article find links to article

2004), "Substance P and neurokinin-1 receptor modulation of HIV", Journal of Neuroimmunology, 157 (1–2): 48–55, doi:10.1016/j.jneuroim.2004.08.022, PMID 15579279

Multiple sclerosis (18,177 words) [view diff] exact match in snippet view article find links to article

involvement in multiple sclerosis etiology and pathogenesis". Journal of Neuroimmunology. 371: 577935. doi:10.1016/j.jneuroim.2022.577935. PMID 35931008

Ulegyria (2,712 words) [view diff] exact match in snippet view article find links to article

damage: Role of glial cells and toll-like receptor signaling". Journal of Neuroimmunology. 229 (1–2): 16–25. doi:10.1016/j.jneuroim.2010.08.008. PMID 20826013

Ken Strauss (4,360 words) [view diff] exact match in snippet view article find links to article

over all other factors in cyclophosphamide-treated patients". Journal of Neuroimmunology. 63 (2): 133–142. doi:10.1016/0165-5728(95)00137-9. ISSN 0165-5728

Michael Belkin (ophthalmologist) (1,793 words) [view diff] exact match in snippet view article

Rescue of spared axons is impaired but regeneration is supported". Journal of Neuroimmunology. 50 (1): 9–16. doi:10.1016/0165-5728(94)90209-7. PMID 8300861

HIV-associated neurocognitive disorder (3,822 words) [view diff] exact match in snippet view article find links to article

"Neuroimaging correlates of HIV-associated BBB compromise". Journal of Neuroimmunology. 157 (1–2): 140–6. doi:10.1016/j.jneuroim.2004.08.025. PMID 15579291

FCRL3 (1,917 words) [view diff] exact match in snippet view article find links to article

and multiple sclerosis pathogenesis: role in autoimmunity?". Journal of Neuroimmunology. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473

Interleukin 10 (4,619 words) [view diff] exact match in snippet view article find links to article

acts in the central nervous system of rats to reduce sleep". Journal of Neuroimmunology. 60 (1–2): 165–168. doi:10.1016/0165-5728(95)00066-b. PMID 7642744

Jaime Imitola (1,252 words) [view diff] exact match in snippet view article find links to article

interactions for translation in neurodegeneration and repair". Journal of Neuroimmunology. 331: 1–3. doi:10.1016/j.jneuroim.2019.04.008. PMID 31023492.

Murine coronavirus (4,193 words) [view diff] exact match in snippet view article find links to article

to promote remyelination in a viral model of demyelination". Journal of Neuroimmunology. 224 (1–2): 101–7. doi:10.1016/j.jneuroim.2010.05.013. PMC 2919340

Coronavirus (10,558 words) [view diff] exact match in snippet view article find links to article

to promote remyelination in a viral model of demyelination". Journal of Neuroimmunology. 224 (1–2): 101–07. doi:10.1016/j.jneuroim.2010.05.013. PMC 2919340

Diagnosis of multiple sclerosis (3,285 words) [view diff] exact match in snippet view article find links to article

cerebrospinal fluid: an update on methodology and clinical usefulness". Journal of Neuroimmunology. 180 (1–2): 17–28. doi:10.1016/j.jneuroim.2006.07.006. PMID 16945427

Toll-like receptor (6,771 words) [view diff] exact match in snippet view article find links to article

morphine and interleukin-1β: evidence for opioid-immune crosstalk". Journal of Neuroimmunology. 227 (1–2): 26–34. doi:10.1016/j.jneuroim.2010.06.007. PMC 2942958

Chromosome 5 open reading frame 47 (1,178 words) [view diff] exact match in snippet view article find links to article

regulatory element sequencing of neuromyelitis optica patients". Journal of Neuroimmunology. 289: 139–142. doi:10.1016/j.jneuroim.2015.11.002. PMID 26616883

Inflammatory demyelinating diseases of the central nervous system (11,718 words) [view diff] exact match in snippet view article find links to article

cerebrospinal fluid: an update on methodology and clinical usefulness". Journal of Neuroimmunology. 180 (1–2): 17–28. doi:10.1016/j.jneuroim.2006.07.006. PMID 16945427

Psychoneuroimmunology (5,450 words) [view diff] exact match in snippet view article find links to article

immune function: A systematic review of human research" (PDF). Journal of Neuroimmunology. 240–241: 1–12. doi:10.1016/j.jneuroim.2011.08.017. PMID 21924504

IGSF6 (1,451 words) [view diff] exact match in snippet view article find links to article

expression profiles in highly active and benign multiple sclerosis. Journal of Neuroimmunology, 358, 577650. https://doi.org/10.1016/j.jneuroim.2021.577650

Helminthic therapy (3,986 words) [view diff] exact match in snippet view article find links to article

of parasite infections on the course of multiple sclerosis". Journal of Neuroimmunology. 233 (1–2): 6–11. doi:10.1016/j.jneuroim.2011.01.002. PMID 21277637

Toxoplasmosis (14,650 words) [view diff] exact match in snippet view article find links to article

seropositivity is negatively associated with multiple sclerosis". Journal of Neuroimmunology. 285: 119–124. doi:10.1016/j.jneuroim.2015.05.011. PMID 26198927

Fibromyalgia (17,867 words) [view diff] exact match in snippet view article find links to article

of patients with fibromyalgia syndrome: A systematic review". Journal of Neuroimmunology. 316: 40–49. doi:10.1016/j.jneuroim.2017.12.007. PMID 29254627

Apolipoprotein D (4,897 words) [view diff] exact match in snippet view article find links to article

intrathecal production of apolipoprotein D in multiple sclerosis". Journal of Neuroimmunology. 119 (2): 327–32. doi:10.1016/s0165-5728(01)00378-2. PMID 11585636

Clinical uses of mesenchymal stem cells (2,731 words) [view diff] exact match in snippet view article find links to article

transplantation in patients with multiple sclerosis: a pilot study". Journal of Neuroimmunology. 227 (1–2): 185–189. doi:10.1016/j.jneuroim.2010.07.013. PMID 20728948

Mir-25 microRNA precursor family (2,367 words) [view diff] exact match in snippet view article find links to article

expression in T regulatory cells in course of multiple sclerosis". Journal of Neuroimmunology. 226 (1–2): 165–71. doi:10.1016/j.jneuroim.2010.06.009. PMID 20637509

Human endogenous retrovirus-W (4,813 words) [view diff] exact match in snippet view article find links to article

receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment". Journal of Neuroimmunology. 291: 29–38. doi:10.1016/j.jneuroim.2015.12.006. PMID 26857492

Marion Buckwalter (2,467 words) [view diff] exact match in snippet view article find links to article

protein are associated with cognitive decline after stroke". Journal of Neuroimmunology. 295–296: 9–11. doi:10.1016/j.jneuroim.2016.04.001. ISSN 0165-5728

Protective autoimmunity (2,526 words) [view diff] exact match in snippet view article find links to article

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease". Journal of Neuroimmunology. 183 (1–2): 60–68. doi:10.1016/j.jneuroim.2006.11.009. PMID 17196666

Changjoon Justin Lee (3,287 words) [view diff] exact match in snippet view article find links to article

and gliosis in neurological diseases – clinical implications". Journal of Neuroimmunology. 231 (1–2): 78–85. doi:10.1016/j.jneuroim.2010.09.020. PMID 20943275

Management of multiple sclerosis (14,020 words) [view diff] exact match in snippet view article find links to article

(February 2011). "Combination therapy in multiple sclerosis". Journal of Neuroimmunology. 231 (1–2): 23–31. doi:10.1016/j.jneuroim.2010.10.021. PMID 21111490

List of autoimmune diseases (6,053 words) [view diff] exact match in snippet view article find links to article

person syndrome spectrum disorders; more than meets the eye". Journal of Neuroimmunology. 369: 577915. doi:10.1016/j.jneuroim.2022.577915. PMC 9274902

Role of microglia in disease (5,051 words) [view diff] exact match in snippet view article find links to article

conditions with wallerian axonal degeneration: A comparative study. Journal of Neuroimmunology Volume 312, 15 November 2017, Pages 49-58 Rojas B, Gallego BI

Plasma gelsolin (9,144 words) [view diff] exact match in snippet view article find links to article

actin toxicity and inflammation in murine multiple sclerosis". Journal of Neuroimmunology. 287: 36–42. doi:10.1016/j.jneuroim.2015.08.006. ISSN 0165-5728

Gut–memory connection (7,109 words) [view diff] exact match in snippet view article find links to article

against gut dysbiosis associated decline in learning and memory". Journal of Neuroimmunology. 348: 577390. doi:10.1016/j.jneuroim.2020.577390. ISSN 0165-5728

Pseudoathletic appearance (5,207 words) [view diff] exact match in snippet view article find links to article

person syndrome spectrum disorders; more than meets the eye". Journal of Neuroimmunology. 369: 577915. doi:10.1016/j.jneuroim.2022.577915. ISSN 1872-8421