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Longer titles found: Tubulin GTPase (view), Tubulin alpha-1A chain (view), Tubulin beta-2A chain (view), Tubulin beta-3 chain (view), Tubulin beta-4A chain (view), Tubulin beta-4B chain (view), Tubulin domain (view), Tubulin polymerization promoting protein family member 3 (view), Tubulinea (view), Tubulinyl-Tyr carboxypeptidase (view), Tubulin—tyrosine ligase (view), Alpha-tubulin 3C (view), Alpha-tubulin N-acetyltransferase (view)

searching for Tubulin 280 found (768 total)

alternate case: tubulin

Depatuxizumab mafodotin (261 words) [view diff] exact match in snippet view article find links to article

of an EGFR IGg1 monoclonal antibody (depatuxizumab) conjugated to the tubulin inhibitor monomethyl auristatin F via a stable maleimidocaproyl link. This

mechanisms that are independent from its ability to bind MET, notably tubulin binding, which likely underlies tivantinib cytotoxicity. Possible applications

evolution of duplication of the alpha-tubulin gene. It was found that C. uncinata contains two paralogs of alpha-tubulin where the variation between the paralogs

gene. This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain

Tubulin-folding cofactor B is a protein that in humans is encoded by the TBCB gene. GRCh38: Ensembl release 89: ENSG00000105254 – Ensembl, May 2017 GRCm38:

formed by an alpha and a beta tubulin molecule carries two GTP molecules, and the GTP is hydrolyzed to GDP when the tubulin dimers are added to the plus

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene. GRCh38: Ensembl release 89: ENSG00000100271 – Ensembl

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene. GRCh38: Ensembl release 89: ENSG00000037042 – Ensembl, May 2017 GRCm38:

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene. Cofactor D is one of four proteins (cofactors A, D, E, and C) involved

noscapine have also been developed. Their mechanism of action is through tubulin inhibition. Various studies have indicated that noscapine has anti-inflammatory

Tau tubulin kinase 1 is a protein that in humans is encoded by the TTBK1 gene. GRCh38: Ensembl release 89: ENSG00000146216 – Ensembl, May 2017 GRCm38:

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene. This protein has been linked to multiple sclerosis myelin

Tubulin tyrosine ligase-like family, member 3 is a protein that in humans is encoded by the TTLL3 gene. GRCh38: Ensembl release 89: ENSG00000214021 –

Tubulin alpha 4b is a protein that in humans is encoded by the TUBA4B gene. GRCh38: Ensembl release 89: ENSG00000243910 – Ensembl, May 2017 "Human PubMed

The duocarmycins are members of a series of related natural products first isolated from Streptomyces bacteria in 1978. They are notable for their extreme

Tubulin, delta 1 is a protein in humans that is encoded by the TUBD1 gene. GRCh38: Ensembl release 89: ENSG00000108423 – Ensembl, May 2017 GRCm38: Ensembl

published a study in 1984 on how tubulin moves in mammalian cells with a focus on the cell cycle. To study the movements in tubulin in cells during mitosis and

homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity

glutamate—[amino group carrier protein] ligase * EC 6.3.2.61: tubulin-glutamate ligase * EC 6.3.2.62: β-tubulin-glutamate ligase * * No Wikipedia article EC 6.3.3

concentration is the concentration of either G-actin (actin) or the alpha,beta- tubulin complex (microtubules) at which the end will remain in an equilibrium state

binding identical protein binding metal ion binding Cellular component gamma-tubulin complex centrosome cytoplasm cytoskeleton microtubule organizing center

repair, and for her pioneering work in deciphering the complexities of the tubulin code. Her work is relevant to the treatment of cancer and nervous system

or microtubule organizing centers rather than interaction directly with tubulin." Mitotic cells are arrested in late prometaphase. Cell entry into mitosis

role of gamma-tubulin" Cell (1994) 76:623-637 Chang, P. and Stearns, T. "Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new

plaque a repeating structure. Spc98p and Spc97p are two similar yeast γ –tubulin (Tub4p) binding proteins required for microtubule nucleation. Spc98p, Spc97p

"Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry

[tau-protein] kinase, tau-protein kinase I, tau-protein kinase II, tau-tubulin kinase, TPK, TPK I, TPK II, and TTK. As of late 2007, 3 structures have

Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis"

factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149

is encoded by the KATNB1 gene. Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize

activity tau-protein kinase activity ubiquitin binding protein binding gamma-tubulin binding ATP binding tau protein binding Cellular component ciliary basal

function microtubule motor activity dynactin binding alpha-tubulin binding protein binding beta-tubulin binding Cellular component cytoplasm ciliary basal body

supranuclear palsy, and corticobasal degeneration. Tau protein, also called tubulin associated unit or microtubule-associated protein tau (MAPT), is a microtubule-associated

Tubulin epsilon and delta complex 2 (TEDC2), also known as Chromosome 16 open reading frame 59 (C16orf59), is a protein that in humans is encoded by the

evolutionary position of opalinids based on 18S rDNA, and alpha- and beta-tubulin gene phylogenies". Journal of Molecular Evolution. 60 (6): 695–705. Bibcode:2005JMolE

ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different

migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. In mammals, ELP3 is important for paternal

recapitulated in non-hematopoietic cells by the expression of Class VI β-tubulin (β6) and they provide a mechanistic basis for understanding these changes

5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity cAMP binding gamma-tubulin binding transmembrane transporter binding phosphoric diester hydrolase

Gene ontology Molecular function alpha-tubulin binding dynein heavy chain binding cytoskeletal motor activity protein binding Cellular component outer

their interaction with tubulin-tyrosine ligase (TTL), an enzyme involved in the tyrosination cycle of the C-terminus of tubulin, and inhibit TTL activity

reported that IGEPAL 630 was ten-fold more potent than Nonidet P-40 in a tubulin polymerisation assay. All IGEPAL CA surfactants are derived from octylphenol

and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates

gregarines (Apicomplexa) as inferred from small-subunit rDNA and beta-tubulin". Int. J. Syst. Evol. Microbiol. 53 (Pt 1): 345–54. doi:10.1099/ijs.0.02284-0

Henry is also a music transcriber and a composer, known for his music tale Tubulin. He has been awarded the rank of Officer in the Ordre des Arts et des Lettres

adequate DNA barcode but there are only six variable sites in Thelebolus; β-tubulin is a recommended secondary barcode. Their ascomata are < 500 ųm diam. and

discovered that there was a binding site for the molecule located on the tubulin, which led them to their next discovery that the microtubules were frozen

Gene ontology Molecular function alpha-tubulin binding protein binding identical protein binding gamma-tubulin binding Cellular component cytoplasm ciliary

(MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells". J. Cell Sci. 112. ( Pt 12) (12): 1813–24. doi:10.1242/jcs

evolutionary division within eukaryotes. A study based on alpha and beta- tubulin phylogenies found that Malawimonas jakobiformis occupied a relatively basal

(September 2004). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". Journal of Cell Science. 117 (Pt

Harrison SC, Chang F (2010). "CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule". Dev. Cell. 19 (2): 245–258. doi:10.1016/j.devcel

complexity. Some are straightforward and static, such as the pattern of tubulin, which is expressed in all cells at all times in life. Some, on the other

S2CID 30242995. Takahashi M, Tomizawa K, Sato K, et al. (1995). "A novel tau-tubulin kinase from bovine brain". FEBS Lett. 372 (1): 59–64. doi:10.1016/0014-5793(95)00955-9

two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480

and protein coding genes: RNA polymerase II largest subunit (RBP2) and b-tubulin) and morphological comparison. Type species, Thozetella nivea is saprobic

complexity. Some are straightforward and static, such as the pattern of tubulin, which is expressed in all cells at all times in life. Some, on the other

two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480

and protein coding genes: RNA polymerase II largest subunit (RBP2) and b-tubulin) and morphological comparison. Type species, Thozetella nivea is saprobic

et al. (2005). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". J. Cell Sci. 117 (Pt 20): 4705–15

(p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms". Biochem. J. 359 (Pt 1): 55–64. doi:10.1042/0264-6021:3590055

contain bacterial tubulin genes, btuba and btubb, which, at this time, are only known bacterial homologs of eukaryotic α- and β-tubulins." See Verrucomicrobiota

8 to 64 nuclei. Megakaryocytes shed platelets into the bloodstream. β1-tubulin microtubules, which are found in megakaryocytes, facilitate this process

Homohalichondrin B, Marine Natural Products Binding in the Vinca Domain of Tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity

is impaired, absent impact on its associated kinase. For example, alpha-tubulin detyrosination has been demonstrated to impact MCAK's mitotic repair capabilities

abolish the catalytic activity of microtubule formation. CNPase can link tubulin to cellular membranes, and might be involved in the regulation cytoplasmic

protein ligase binding SNARE binding protein homodimerization activity beta-tubulin binding calcium-dependent phospholipid binding phosphatidylserine binding

ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed

the action of oil drying agents Tubulin polymerisation inhibitors - chemotherapy drugs that interfere with the tubulin system Khuong, Kelli S.; Jones,

and shrink for important cell functions. Colchicine binds to β- tubulin and forms tubulin-colchicine complexes. These complexes interfere with microtubule

gregarines (Apicomplexa) as inferred from small-subunit rDNA and beta-tubulin". International Journal of Systematic and Evolutionary Microbiology. 53

binding gamma-tubulin binding protein C-terminus binding oxidoreductase activity Cellular component cytoplasm cytosol BLOC-1 complex gamma-tubulin complex microtubule

binding alpha-tubulin binding microtubule-severing ATPase activity protein binding catalytic activity hydrolase activity ATP binding beta-tubulin binding microtubule

binding alpha-tubulin binding SH2 domain binding calmodulin binding actin filament binding ion channel activity protein binding beta-tubulin binding cation

or β tubulin to a cytosolic chaperonin. The prefoldin, however, does not form a ternary complex with tubulin and chaperonin. Once the tubulins are in

more commonly known as vincristine, is a mitotic inhibitor. It binds to tubulin dimers, inhibiting the assembly of microtubule structures like the cytoskeleton

A (May 2001). "Stathmin family proteins display specific molecular and tubulin binding properties". The Journal of Biological Chemistry. 276 (19): 16146–54

regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation". J. Biol. Chem. 276 (16): 12839–48. doi:10.1074/jbc

deoxyribonuclease activity microtubule binding tubulin binding actin filament binding protein binding beta-tubulin binding identical protein binding actin binding

transport protein 88 (IFT88), which are required for tubulin requitment to centrosome and transport of tubulin to the cilia tip, respectively. GRCh38: Ensembl

Martin, SS (Oct 2010). "Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement"

ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. The Journal of Clinical Investigation. 1997. KM Murphy, V Ranganathan

Bommel H, Xie G, Rossoll W, et al. (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor

cancer (NSCLC) is strongly associated with overexpression of beta III tubulin. Investigations by the Children's Cancer Institute Australia (University

kinase kinase activity alpha-tubulin binding protein serine/threonine kinase activator activity tau protein binding beta-tubulin binding tau-protein kinase

structures such as contractile ring formation formed by both actin and tubulin type structures leading to the same mechanical result of cell division

protein heterodimerization activity ATP binding dynein complex binding beta-tubulin binding protein-containing complex binding Cellular component cytosol meiotic

CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112

function microtubule binding alpha-tubulin binding metal ion binding protein binding beta-tubulin binding gamma-tubulin binding protein kinase binding

found that encode basal body orientation factors. A similar set of genes, tubulin tyrosine ligase-like genes 3 and 6, has been found in zebrafish that maintain

body like CEP170 or proteins which are required for cilium formation like tubulin chaperone and membrane proteins. Due to the importance of IFT in maintaining

Croucher DR, Mace PD (September 2020). "A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers". Proceedings of the National Academy of

binding protein binding beta-tubulin binding transcription coregulator activity Cellular component cytoplasm centrosome gamma-tubulin complex cytoskeleton nucleus

work on microtubules established their unusual molecular assembly from tubulin proteins and identified the first microtubule-stabilizing protein tau,

Type I : Walker type P-loop ATPase Type II : Actin-like ATPase Type III : tubulin-like GTPase Type IV : No NTPase This system is also used by most bacteria

composed of polymers consisting of the protein tubulin. Therefore, paclitaxel binds at the site of β-tubulin and induces polymerization, thus protecting

"Release of tyrosine from tyrosinated tubulin. Some common factors that affect this process and the assembly of tubulin". FEBS Letters. 73 (2): 147–150. doi:10

Yamagishi N, Ishihara K, Hatayama T (2003). "Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system". Exp

"Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype". Cancer Chemotherapy and Pharmacology. 76 (5): 1013–1024. doi:10

V, Valpuesta JM, Carrera AC (Sep 2009). "SADB phosphorylation of gamma-tubulin regulates centrosome duplication". Nature Cell Biology. 11 (9): 1081–92

Eriksson E, Berbee ML (2001). "Neolecta—a fungal dinosaur? Evidence from β-tubulin amino acid sequences". Mycologia. 93 (6). Mycological Society of America:

division site of higher-plant cells, a tobacco BY-2 cell line expressing GFP-tubulin". Protoplasma. 222 (3–4): 157–165. doi:10.1007/s00709-003-0012-8. PMID 14714204

"Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". The Journal of Biological Chemistry. 276 (44): 41023–8. doi:10

Matthew P. Scott. Raff, E.C. and M. T. Fuller, et al., "Regulation of tubulin gene expression during embryogenesis in Drosophila melanogaster", Cell

encoding protein TBC1 domain family, member 24 TEDC2: encoding protein Tubulin epsilon and delta complex 2 TELO2: encoding protein Telomere length regulation

"Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization". Bioorganic & Medicinal Chemistry Letters. 3 (4): 581–4

S2CID 14132033. Haren L, Merdes A (2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and

"Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–8. doi:10.1074/jbc.M106591200

Masayoshi; Hashimoto, Takashi (2009-07-01). "A mutation in the Arabidopsis γ-tubulin-containing complex causes helical growth and abnormal microtubule branching"

divisio nova/ Kathablepharida phylum novum based on SSU rDNA and beta-tubulin phylogeny". Protist. 156 (2): 163–79. doi:10.1016/j.protis.2004.12.003

CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112

Willard FS, Crouch MF (2001). "MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic

CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112

centrosome centriolar satellite cytoskeleton Biological process gamma-tubulin complex localization centriole replication spindle organization G2/M transition

common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes". Genes & Development. 8 (4): 491–501

"Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

transcription activator activity, RNA polymerase II-specific chromatin binding tubulin binding kinase binding protein binding DNA-binding transcription factor

Willard FS, Crouch MF (2001). "MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic

activity protein binding symporter activity metal ion binding beta-tubulin binding alpha-tubulin binding actin binding Cellular component integral component

binding identical protein binding fibroblast growth factor binding gamma-tubulin binding Cellular component cytosol centrosome Golgi apparatus microtubule

follows: Trastuzumab/HER-2/neu, Antiestrogens/Estrogen Receptor, Taxanes/beta-tubulin III, 5FU/Thymidylate Synthase. In these trials DirectHit analysis of estrogen

homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation Sources:Amigo

but substantially longer. Comparisons of genes coding for 𝛼-tubulin, 𝛽-tubulin, 𝛾-tubulin, EF-1𝛼, EF-2, cytHSP70, ubiquitin, 18S rRNA, and HSP90 allow

Sabry, J.; O’Connor, T. P.; Kirschner, M. W. (1995). "Axonal Transport of Tubulin in Ti1 Pioneer Neurons in Situ". Neuron. 14 (6): 1247–1256. doi:10

Gene ontology Molecular function tubulin binding enzyme binding scaffold protein binding DNA binding ribonucleoprotein complex binding histone binding

permeable to enzymes involved in the degradation of the NE such as cytoplasmic tubulin, as well as allowing the entry of key mitotic regulator proteins. In organisms

consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease". Journal of Cell Science. 115 (Pt 5):

CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112

function protein binding cytoskeletal motor activity microtubule binding tubulin binding dynein complex binding protein kinase binding tau protein binding

Etiévant C, Colpaert F, Fahy J, Hill BT (March 1998). "Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid"

sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". The Biochemical Journal. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599

increase or accumulation of γ-tubulin ring complexes and other PCM proteins at the centrosome. This increase in γ -tubulin gives the mature centrosome greater

Katablepharidophyta Divisio Nova/Kathablepharida Phylum Novum Based on SSU rDNA and Beta-Tubulin Phylogeny". Protist. 156 (2): 163–179. doi:10.1016/j.protis.2004.12.003

"Phylogenetic analysis of Penicillium subgenus Penicillium using partial β-tubulin sequences" (PDF). Studies in Mycology. 49: 175–200. Pitt JI, Basílico JC

of the Phialophora verrucosa complex: new insights from analyses of β-tubulin, large subunit nuclear rDNA and ITS sequences". Botany. 86 (7): 742–750

fellowship to work on crystallising FtsZ, a bacterial homologue of eukaryotic tubulin, with Linda A. Amos. Löwe became a group leader at MRC-LMB in 1998 and

loss. Based on sequence similarities, CCP1 was proposed to be involved in tubulin processing along with five other carboxypeptidases, designated CCP2 to

geranylgeranyltransferase activity receptor tyrosine kinase binding alpha-tubulin binding protein farnesyltransferase activity acetylcholine receptor regulator

2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". Journal of Neurochemistry. 80 (6): 980–988. doi:10.1046/j.0022-3042.2002

alpha-tubulin binding chaperone binding G protein-coupled receptor binding heat shock protein binding ubiquitin protein ligase binding beta-tubulin binding

Gene ontology Molecular function histone deacetylase binding alpha-tubulin binding Cellular component nucleus cytoplasm microtubule spindle pole cytoskeleton

a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Monophyletic groups within the Parmeliaceae identified by ITS rDNA, β-tubulin and GAPDH sequences. Mycological Progress 3: 297-314. https://doi.org/10

CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112

histone binding chromatin binding acetyltransferase activator activity beta-tubulin binding histone acetyltransferase binding transcription factor binding

Serine/threonine kinase 11 (Peutz-Jeghers syndrome) TBCB: encoding protein Tubulin-folding cofactor B TECR: encoding enzyme Trans-2,3-enoyl-CoA reductase

Wadle A, Fadle N, Gerlach K, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10

Serine/threonine kinase 11 (Peutz-Jeghers syndrome) TBCB: encoding protein Tubulin-folding cofactor B TECR: encoding enzyme Trans-2,3-enoyl-CoA reductase

antitumor activity is due to inhibition of mitosis through interaction with tubulin. Vinorelbine was invented by the pharmacist Pierre Potier and his team

two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480

Katablepharidophyta Divisio Nova/Kathablepharida Phylum Novum Based on SSU rDNA and Beta-Tubulin Phylogeny". Protist. 156 (2): 163–179. doi:10.1016/j.protis.2004.12.003

CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc

protein tetratricopeptide repeat domain 28 TTLL1: encoding enzyme probable tubulin polyglutamylase TTLL1 XRCC6: encoding protein Ku70 The following diseases

the nucleus splits in two. In macronuclear amitosis of Tetrahymena, γ-tubulin-mediated MT assembly was required. There are multiple reports of amitosis

encoding protein Tripartite motif containing 38 TTBK1: encoding protein Tau tubulin kinase 1 UBR2: ubiquitin protein ligase E3 component n-recognin 2 (6p21

homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation Sources:Amigo

development is reduced. Reducing CD99 expression results in higher β-III tubulin expression and more neurite outgrowth. Upregulating CD99 expression in

protein binding alpha-tubulin binding glycosyltransferase activity lactose synthase activity transferase activity beta-tubulin binding UDP-galactosyltransferase

phospholipid binding microtubule binding cytoskeletal protein binding tubulin binding Cellular component plasma membrane clathrin-coated pit membrane

Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor

"Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. 270 (43): 25985–91

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

typing (MLST) study of three protein-encoding genes: enolase (enoA), β-tubulin (benA), and calmodulin (calM). They chose the species epithet "alabamensis"

SPZ1: Spermatogenic leucine zipper protein 1 STC2: Stanniocalcin-2 TBCA: Tubulin-specific chaperone A TCOF1: Treacher Collins-Franceschetti syndrome 1 TGFBI:

"Phylogenetic analysis of Penicillium subgenus Penicillium using partial β-tubulin sequences" (PDF). Studies in Mycology. 49: 175–200. Archived from the original

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

protein 2A SPRTN: Spartan TARBP1: TAR (HIV-1) RNA-binding protein 1 TBCE: Tubulin-specific chaperone E THBS3: Thrombospondin 3 TMCO1: Transmembrane and coiled-coil

2013). "A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate

(2010). "The prognostic significance of ERCC1, BRCA1, XRCC1, and betaIII-tubulin expression in patients with non-small cell lung cancer treated by platinum-

ISSN 1179-3163. Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization. John A. Beutler, John H. Cardellina, Chii M. Lin, Ernest

A middle stage midbody stained with tubulin

SH; Kim, C; An, G (2000). "Tissue-Preferential Expression of a Rice α-Tubulin Gene, OsTubA1, Mediated by the First Intron". Plant Physiology. 123 (3):

encoding protein Testis specific 10 TTN: titin TUBA4B: encoding protein Tubulin alpha 4b UBE2F: encoding protein Ubiquitin conjugating enzyme E2 F (putative)

Colpaert, Francis; Fahy, Jacques; Hill, Bridget T. (1998). "Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid"

Gene ontology Molecular function cytoskeletal protein binding tubulin binding fructose binding protein binding catalytic activity lyase activity actin

Deacetylase Cell cycle, tumorigenesis 65-340 (of 388aa) H3K56ac, H4K16ac Tubulin, Foxo3a, EIF5A, P53, G6PD, MYC Neurodegenerative diseases, Cancer: brain

Composed of tubulin proteins, microtubules are dynamic structures that allows them to shrink or grow with the addition or removal of tubulin proteins. In

mebendazole. Benzimidazoles kill adult worms by binding to the nematode’s β-tubulin and subsequently inhibiting microtubule polymerization within the parasite

gov/gene/283643> "Summary - Homo sapiens - Ensembl genome browser 97". "Homo sapiens tubulin epsilon and delta complex 1 (TEDC1), transcript variant 1, mRNA". 2018-12-04

cytoplasm cytosol centrosome cell projection MKS complex membrane gamma-tubulin complex centriolar satellite ciliary transition zone cilium photoreceptor

expression is downregulated with maturation Neuron-specific Class III β-tubulin (TuJ1) is present in newly generated immature postmitotic neurons and differentiated

"Monophyletic groups within the Parmeliaceae identified by ITS rDNA, β-tubulin and GAPDH sequences". Mycological Progress. 3 (4): 297–314. doi:10.1007/s11557-006-0100-1

revealed genetic divergence among both populations, at specific loci (ß-tubulin, RPB2). However, due to high levels of within-population diversity of the

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

Docking of Its Main Metabolites (Apigenin, Kaempferol, and Quercetin) on β-Tubulin". Molecules. 26 (2): 443. doi:10.3390/molecules26020443. ISSN 1420-3049

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513

tri- and tetrasubstituted olefins related to isoCombretastatin A-4 as new tubulin inhibitors. Org. Biomol. Chem., 2013,11, 430-442. doi:10.1039/C2OB26253C

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

Catherine; Gredt, Michel; Leroux, Pierre (1999-05-01). "Mutations of the β-Tubulin Gene Associated with Different Phenotypes of Benzimidazole Resistance in

1alpha with rat brain proteins: evidence for a direct interaction with tubulin". Journal of Neurochemistry. 72 (1): 346–354. doi:10.1046/j.1471-4159.1999

(2004-01-15). "Mutations in -tubulin promote basal body maturation and flagellar assembly in the absence of -tubulin". Journal of Cell Science. 117

ISSN 0021-9258. PMC 4705984. PMID 26657753. Moritz, CP. (2017-09-20). "Tubulin or not tubulin: Heading toward total protein staining as loading control in Western

control of cell-type specific promoter, such as nsyb (to target neurons) or tubulin (to target all cells). QUAS is analogous to UAS and LexAop, and is placed

"Hemisynthesis of rhazinilam analogues: structure - activity relationships on tubulin-microtubule system". Bioorganic & Medicinal Chemistry Letters. 7 (17):

species of the genus of Penicillium which was isolated from plant leaves in China. Penicillium qii strain AS3.15343 beta-tubulin (benA) UniProt v t e

Gene ontology Molecular function tubulin binding protein binding GTPase activator activity Cellular component cytoplasm cytosol centrosome cytoskeleton

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

Davidson, KGV; et al. Connexin-43 interactions with ZO-1 and alpha-and beta-tubulin - Giepmans, BNG; Verlaan, I; Moolenaar, WH Connexin channels, connexin

Browser. Takahashi M, Tomizawa K, Sato K, et al. (1995). "A novel tau-tubulin kinase from bovine brain". FEBS Lett. 372 (1): 59–64. doi:10.1016/0014-5793(95)00955-9

adaptor activity sodium channel regulator activity connexin binding alpha-tubulin binding protein-containing complex binding enzyme binding nitric-oxide

Gene ontology Molecular function chromatin binding beta-tubulin binding protein binding Cellular component intraciliary transport particle B centrosome

interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". J. Struct. Biol. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270

phospholipid binding microtubule binding cytoskeletal protein binding tubulin binding Cellular component plasma membrane clathrin-coated pit membrane

compressed or deformed, asymmetric spindles still form, and staining for gamma tubulin reveals that the second microtubule organizing center lacks the molecular

2008). "Prosthecobacter fluviatilis sp. nov., which lacks the bacterial tubulin btubA and btubB genes". International Journal of Systematic and Evolutionary

Aspergillus flavus: Characterization by Internal Transcribed Spacer, 􏰀-Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted

adaptor activity sodium channel regulator activity connexin binding alpha-tubulin binding protein-containing complex binding enzyme binding nitric-oxide

compressed or deformed, asymmetric spindles still form, and staining for gamma tubulin reveals that the second microtubule organizing center lacks the molecular

2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". Journal of Neurochemistry. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002

was originally thought to fold only the cytoskeletal proteins actin and tubulin but is now known to fold dozens of substrates. Methanococcus maripaludis

Gene ontology Molecular function chromatin binding beta-tubulin binding protein binding Cellular component intraciliary transport particle B centrosome

loss. Dalton also led the research group that invented sabizabulin, a tubulin inhibitor under development for the treatment of cancer and SARS-CoV-2

interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". J. Struct. Biol. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270

Ryten M, et al. (April 2013). "Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia". Annals of Neurology. 73 (4): 546–553. doi:10

and thermodynamic analysis of taxol-induced polymerization of purified tubulin". Biochemistry and Cell Biology. 65 (6): 558–564. doi:10.1139/o87-072.

N-methyltransferase activity protein-lysine N-methyltransferase activity alpha-tubulin binding histone methyltransferase activity (H3-K36 specific) metal ion

microtubule binding structural molecule activity protein binding actin binding tubulin binding phospholipid binding protein-containing complex binding Cellular

phosphoglucomutase 1-T466, SMART/HDAC1-associated repressor protein-S3486-T3568, Tubulin Cofactor B-S65-S128, Snail-S246 vascular endothelial-cadherin-S665, poly(RC)

function calcium ion binding protein C-terminus binding protein binding alpha-tubulin binding Cellular component cytoplasm axoneme soma centrosome spindle mitotic

cell movement when their dynamics are suppressed by drug treatment or by tubulin mutations. An area of research called inverse problems in cell motility

Gene ontology Molecular function alpha-tubulin binding protein binding beta-tubulin binding oligopeptidase activity microtubule binding identical protein

sodium channel regulator activity transmembrane transporter binding beta-tubulin binding Cellular component cell projection filopodium growth cone extracellular

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

C; Potenziano, JL; Bane, S; Engelborghs, Y (1997). "The mechanism of tubulin-colchicine recognition--a kinetic study of the binding of a bicyclic colchicine

"Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". The Journal of Biological Chemistry. 279 (6): 4196–203. doi:10

activity involved in chemorepulsion protein binding protein kinase binding tubulin binding Cellular component integral component of membrane neuron projection

between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells". The Journal of Biological Chemistry. 270 (51): 30241–4

Gene ontology Molecular function carboxypeptidase activity tubulin binding zinc ion binding peptidase activity hydrolase activity metallopeptidase activity

hydrogen peroxide response to hypoxia lens development in camera-type eye tubulin complex assembly muscle organ development multicellular organism aging

"Monophyletic groups within the Parmeliaceae identified by ITS rDNA, β-tubulin and GAPDH sequences". Mycological Progress. 3 (4): 297–314. doi:10.1007/s11557-006-0100-1

RPGRORF15 isoform has been shown to be glutamylated on its N-terminus by tubulin-tyrosine ligase-like 5 (TTLL5). It has also been shown that loss of TTLL5

with a coding region of 1233bp. LIS1 protein appears to interact with tubulin to suppress microtubule dynamics. The protein is highly conserved and studies

"Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200

phosphorylation cell division neuron projection morphogenesis regulation of tubulin deacetylation protein phosphorylation mitotic cell cycle Sources:Amigo

protein binding single-stranded RNA binding RNA binding microtubule binding tubulin binding Cellular component cytoplasm microtubule cytoskeleton nucleus manchette

Gene ontology Molecular function tubulin binding protein binding Cellular component intraciliary transport particle B ciliary basal body centrosome sperm

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

Gene ontology Molecular function microtubule binding SH3 domain binding tubulin binding protein binding phospholipid binding cytoskeletal protein binding

"Use of substitute Nonidet P-40 nonionic detergents in intracellular tubulin polymerization assays for screening of microtubule targeting agents". Biochemistry

Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10

"Use of substitute Nonidet P-40 nonionic detergents in intracellular tubulin polymerization assays for screening of microtubule targeting agents". Biochemistry

Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10

Gene ontology Molecular function microtubule binding SH3 domain binding tubulin binding protein binding phospholipid binding cytoskeletal protein binding

Berwald-Netter Y, Gros F (1989). "Posttranslational modifications of tubulin in cultured mouse brain neurons and astroglia". Biol. Cell. 65 (2): 109–117

"Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200

intracellular distribution of mitochondria histone H4-K12 acetylation alpha-tubulin acetylation midbrain development protein deubiquitination cytokine production

"Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200

lodging tolerance in tef (Eragrostis tef) is linked to a mutation in the α-Tubulin 1 gene". Journal of Experimental Botany. 66 (3): 933–944. doi:10.1093/jxb/eru452

cytosol centrosome spindle pole membrane microtubule cytoskeleton gamma-tubulin complex microtubule organizing center microtubule plus-end cytoskeleton

called the polar ring, and among the Conoidasida is also a funnel of tubulin proteins called the conoid. Over the rest of the cell, except for a diminished

protein binding single-stranded RNA binding RNA binding microtubule binding tubulin binding Cellular component cytoplasm microtubule cytoskeleton nucleus manchette

epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". J. Biol. Chem. 278 (31): 28823–30. doi:10.1074/jbc.M300995200

Gene ontology Molecular function microtubule binding tubulin binding growth factor activity Cellular component cytoplasm cytosol nucleus nucleoplasm extracellular

polymeric structures. They are composed of alpha- and beta-tubulin heterodimers. Sagopilone induces tubulin polymerization and therefore shows antitumor activity

and remodeling of the peptidoglycan cell wall at the division site. A tubulin-like protein, FtsZ plays a critical role in formation of a contractile

with G inhibitory proteins, the Src family kinase (SFK) member c-fyn, and tubulin within lipid rafts.[citation needed] In rats and mice, Thy-1 protein is

activity protein N-terminus binding microtubule binding protein binding beta-tubulin binding signaling receptor binding Cellular component integral component

DNA binding microtubule binding ubiquitin protein ligase binding beta-tubulin binding actin filament binding DNA binding endonuclease activity RNA binding

Gene ontology Molecular function actin binding gamma-tubulin binding protein binding protein domain specific binding Cellular component cytosol cell junction

2017). "Use of substitute Nonidet P-40 nonionic detergents in intraellular tubulin polymerization assays for screening of microtubulte targeting agents".

body PML body nuclear speck spindle pole ubiquitin ligase complex gamma-tubulin complex photoreceptor connecting cilium midbody cytoplasmic dynein complex

phospholipid binding phospholipid binding lipid binding microtubule binding alpha-tubulin binding Cellular component integral component of membrane endosome late

Boulan, Benoit; Vossier, Frédérique (2017-12-15). "Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation". Science

Gene ontology Molecular function tubulin binding calcium ion binding protein binding microtubule binding Cellular component cytoplasm perinuclear region

Varin-Blank N, Calvo F (December 2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis"

Palladino MA, Kiso Y, Hayashi Y, Neuteboom ST (2006). "NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting

activity microtubule binding microtubule plus-end binding metal ion binding tubulin binding protein binding zinc ion binding identical protein binding Cellular

Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin". J Cell Biol. 143 (4): 1041–52. doi:10.1083/jcb.143.4.1041. PMC 2132962

Hoogenboom H, Pfreundschuh M, Renner C (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10

mutation in the PSEN1 gene. TUJ-1-positive cells express a marker (β3-tubulin) of mature neurons (red). GABA-positive cells (green). Cell nuclei are

ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms

activity protein domain specific binding ubiquitin protein ligase binding tubulin binding S100 protein binding Cellular component nuclear envelope lumen

interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". Journal of Structural Biology. 135 (2): 205–18. doi:10.1006/jsbi.2001

Pestalotiopsis species in Pinus armandii and Ribes spp.: Evidence from rDNA and β-Tubulin gene phylogenies". Fungal Divers. 24: 1–22. De Groot, J.J.M. (2003). The

(2002). "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C". J. Biol. Chem. 277 (17): 14629–34. doi:10

Gene ontology Molecular function tubulin binding GPI-anchor transamidase activity GPI anchor binding protein binding Cellular component integral component

ignored (help) Fukata Y, Itoh TJ, Kimura T, et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly". Nat. Cell Biol. 4 (8): 583–91

protein homodimerization activity microtubule binding protein binding beta-tubulin binding protein heterodimerization activity enzyme binding cadherin binding