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searching for Small interfering RNA 53 found (148 total)

RNA polymerase V (604 words) [view diff] exact match in snippet view article find links to article

polymerase. It is required for normal function and biogenesis of small interfering RNA (siRNA). Together with RNA polymerase IV (Pol IV), Pol V is involved

Dharmacon (554 words) [view diff] exact match in snippet view article find links to article

important resource for those investigating the mechanisms of siRNA (small interfering RNA)-induced gene knockdown and applying the specificity and potency

Haemophilia B (2,519 words) [view diff] exact match in snippet view article find links to article

Antibodies Fitusiran: An investigational therapy that utilizes small interfering RNA (siRNA) technology to reduce antithrombin levels, thereby increasing

Obscurin (2,500 words) [view diff] exact match in snippet view article find links to article

cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing" (PDF). Histochemistry and Cell Biology

Mir-390 microRNA precursor family (1,387 words) [view diff] exact match in snippet view article find links to article

2010). "Auxin regulation of the microRNA390-dependent transacting small interfering RNA pathway in Arabidopsis lateral root development". Nucleic Acids

CUZD1 (406 words) [view diff] exact match in snippet view article find links to article

SK, Huynh H (2007). "Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro". Oncogene

Gene knockdown (1,611 words) [view diff] exact match in snippet view article find links to article

gene-binding), the degradation of the mRNA transcript (e.g. by small interfering RNA (siRNA)) or RNase-H dependent antisense, or through the blocking

Institute of Molecular Biotechnology (2,636 words) [view diff] exact match in snippet view article find links to article

model human brain development 2008. Discovery of an endogenous small interfering RNA pathway in Drosophila. 2005. Discovery of the role of angiotensin

MKNK1 (1,031 words) [view diff] exact match in snippet view article find links to article

VM, Salinas M, Martín ME (2005). "Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T

ZAK (1,062 words) [view diff] exact match in snippet view article find links to article

aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA". Journal of Biological Chemistry. 280 (19): 19298–19305. doi:10

Olpasiran (234 words) [view diff] case mismatch in snippet view article find links to article

You; Kassahun, Helina; Sabatine, Marc S. (17 November 2022). "Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease". New England

EHF (gene) (865 words) [view diff] exact match in snippet view article

PMC 1847948. PMID 17353931. Park C, Lee I, Kang WK (2007). "Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated

Centromere protein E (1,069 words) [view diff] exact match in snippet view article find links to article

Russell L, Chin G, Schebye XM (2005). "Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic

HOXC6 (1,241 words) [view diff] exact match in snippet view article find links to article

mesenchymal transition for the cervical carcinoma. A knockout model using small interfering RNA showed that knockout of HOXC6 was associated with apoptosis. Additionally

USP22 (526 words) [view diff] exact match in snippet view article find links to article

Zhang Y, Liang R, Wang LM (December 2012). "Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell

Alnylam Pharmaceuticals (1,788 words) [view diff] exact match in snippet view article find links to article

Food and Drug Administration (FDA) approved Leqvio (inclisiran), a small interfering RNA (siRNA) therapy to lower low-density lipoprotein cholesterol. Leqvio

RhoC (1,946 words) [view diff] exact match in snippet view article find links to article

Urogenital System Melanoma Prostate Cancer Cervical Carcinoma RhoC small interfering RNA (siRNA) have been used in studies to successfully inhibit proliferation

Primary hyperoxaluria (1,905 words) [view diff] exact match in snippet view article find links to article

the United States in September 2023. RIVFLOZA is an LDHA-directed small interfering RNA indicated to lower urinary oxalate levels in children 9 years of

PLS3 (817 words) [view diff] exact match in snippet view article find links to article

T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents". Int

EIF2C1 (733 words) [view diff] exact match in snippet view article find links to article

K, Patel DJ (May 2004). "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain". Nature. 429 (6989): 318–22. Bibcode:2004Natur

SM-102 (628 words) [view diff] no match in snippet view article find links to article

"Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver". Molecular Therapy. 18 (9): 1657–1666. doi:10.1038/mt

Mir-430 microRNA precursor family (784 words) [view diff] exact match in snippet view article find links to article

A, Larsen N, Helvik JV, Drivenes Ø (May 2008). "Treatment with small interfering RNA affects the microRNA pathway and causes unspecific defects in zebrafish

Small conditional RNA (464 words) [view diff] exact match in snippet view article find links to article

'detection target' mRNA X, with subsequent Dicer processing yielding a small interfering RNA (siRNA) targeting mRNA Y for destruction (Figure 3). In this context

Mir-193 microRNA precursor family (406 words) [view diff] exact match in snippet view article find links to article

C, Leng N, Brown D (November 2007). "Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis

RRM2B (1,508 words) [view diff] exact match in snippet view article find links to article

Aikou T (September 2007). "Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma". Oncology

IDH2 (2,094 words) [view diff] exact match in snippet view article find links to article

PMID 16396496. Kil IS, Kim SY, Lee SJ, Park JW (October 2007). "Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase

Hytrosaviridae (3,685 words) [view diff] exact match in snippet view article find links to article

latency. Host's RNA interference (RNAi) machineries such as the small interfering RNA (siRNA) and micro RNA (miRNA) pathways have been implicated in keeping

Exosome component 5 (971 words) [view diff] exact match in snippet view article find links to article

co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector". Biochemical and Biophysical Research Communications

HEMGN (815 words) [view diff] exact match in snippet view article find links to article

(2007). "Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncol

Diallyl disulfide (2,797 words) [view diff] exact match in snippet view article find links to article

Huang, Z; Lei, X; Zhong, M; Zhu, B; Tang, S; Liao, D (2007). "Bcl-2 small interfering RNA sensitizes cisplatin-resistant human lung adenocarcinoma A549/DDP

PRC1 (1,806 words) [view diff] exact match in snippet view article find links to article

SA, Perard J, Yen TJ, Margolis RL (2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle

Neurokinin A (2,876 words) [view diff] case mismatch in snippet view article find links to article

Tachykinin Neurokinin 1 Receptor By Intrathecal Administration Of Small Interfering RNA In Rats". European Journal of Pharmacology. 670 (2/3): 448–457.

Fig4 (2,787 words) [view diff] exact match in snippet view article find links to article

adipocytes inhibits the Sac3 phosphatase activity as measured in vitro. Small interfering RNA-mediated knockdown of endogenous Sac3 by ~60%, resulting in a slight

Repeated sequence (DNA) (3,832 words) [view diff] exact match in snippet view article

methylation, histone modifications, non-coding RNAs (ncRNAs) including small interfering RNA (siRNA), chromatin remodelers, histone variants, and other epigenetic

Transcriptome in vivo analysis tag (1,353 words) [view diff] exact match in snippet view article find links to article

Wu H, McBride JL, et al. (July 2007). "Transvascular delivery of small interfering RNA to the central nervous system". Nature. 448 (7149): 39–43. Bibcode:2007Natur

Gene knockout (2,563 words) [view diff] exact match in snippet view article find links to article

(RNAi), messenger RNA for a particular gene is inactivated using small interfering RNA (siRNA) or short hairpin RNA (shRNA). This effectively stops the

Robin Allshire (2,486 words) [view diff] exact match in snippet view article find links to article

Alastair R W; Allshire, Robin C (2010). "Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast". EMBO Reports

Hypoxia-inducible factor (4,885 words) [view diff] exact match in snippet view article find links to article

HIF-1α expression in the presence of normal oxygen pressure. siRNA (small interfering RNA) studies for individual NF-κB members revealed differential effects

Stephen Friend (2,484 words) [view diff] exact match in snippet view article find links to article

Ferrer, M; Strulovici, B; Friend, S. H.; Linsley, P. S. (2006). "Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having

Anil Suri (1,156 words) [view diff] exact match in snippet view article find links to article

Medical Sciences, and one from the National Academy of Sciences. Small interfering RNA-mediated down regulation of Sperm-Associated Antigen 9 inhibits

DUT (gene) (1,955 words) [view diff] exact match in snippet view article

Kloesel R, Williams MV (Feb 2005). "Modulation of human dUTPase using small interfering RNA". Biochemical and Biophysical Research Communications. 327 (1):

PFKFB3 (3,772 words) [view diff] exact match in snippet view article find links to article

to oxidative stress and neuronal death. Silencing of PFKFB3 with small interfering RNA in neurons in vitro prevents the increase in ROS and apoptotic death

ANLN (2,939 words) [view diff] exact match in snippet view article find links to article

SA, Perard J, Yen TJ, et al. (March 2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle

Eukaryotic transcription (5,867 words) [view diff] exact match in snippet view article find links to article

nucleus messenger RNA (mRNA), most small nuclear RNAs (snRNAs), small interfering RNA (siRNAs) and microRNA (miRNA). RNA Polymerase III (Pol III, Pol

History of RNA biology (4,639 words) [view diff] exact match in snippet view article find links to article

discovered in the 1990s. Small RNA molecules termed microRNA (miRNA) and small interfering RNA (siRNA) are abundant in eukaryotic cells and exert post-transcriptional

AGR2 (3,024 words) [view diff] exact match in snippet view article find links to article

pancreatic tumors and cancer cell lines. Transient silencing of AGR2 by small interfering RNA and short hairpin RNA significantly reduces cell proliferation and

Microbubble (3,928 words) [view diff] exact match in snippet view article find links to article

methods. Microbubbles have been used to deliver microRNAs, plasmids, small interfering RNA, and messenger RNA. Microbubbles do not extravasate easily due to

Overlapping gene (5,334 words) [view diff] exact match in snippet view article find links to article

Ye K, Malinina L, Patel DJ (3 December 2003). "Recognition of small interfering RNA by a viral suppressor of RNA silencing". Nature. 426 (6968): 874–878

PCSK9 (7,706 words) [view diff] exact match in snippet view article find links to article

(2023). "Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and

DNA methylation (13,345 words) [view diff] exact match in snippet view article find links to article

double-stranded RNA molecules. The double-stranded RNAs, through either the small interfering RNA (siRNA) or microRNA (miRNA) pathways direct de-novo DNA methylation

Organoid (9,292 words) [view diff] case mismatch in snippet view article find links to article

Organoids with Graphene Oxide-Mediated Tumor Necrosis Factor-α_Small Interfering RNA Delivery". Langmuir. 40 (7): 3402–3413. doi:10.1021/acs.langmuir

Artificial enzyme (13,631 words) [view diff] exact match in snippet view article find links to article

antioxidant banozyme for biomedical applications. Combined with small interfering RNA, ceria nanozyme was used for synergistic treatment of neurodegenerative

Laser-assisted drug delivery (5,473 words) [view diff] exact match in snippet view article find links to article

analgesics, minoxidil (MXD), diphencyprone (DPCP), vitamin C, small interfering RNA (siRNA), vaccine, and antibodies. The efficiency of LADD with the